A traditional Chinese medicine composition for treating infectious gastroenteritis of mammal piglets

Abstract

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating transmissible gastroenteritis (TGE) of lactating piglets, which effectively solves the problem that the prior art is only directed to the transmissible gastroenteritis with a low mortality rate of the piglets or sows with a mild disease, is not directed to the TGE with a high mortality rate of the lactating piglets with a severe disease, and cannot rapidly correct the problems of dehydration and acidosis of the lactating piglets, compared with the prior art, the traditional Chinese medicine composition for treating the TGE of the lactating piglets comprises Nansha-Shen, Beisha-Shen, Shihu, Yuzhu, Oyster, and can nourish Yin and produce body fluid, can effectively improve the dehydration and metabolic acidosis of the lactating piglets, and achieve the effects of treating the TGE and reducing the mortality rate, and the reasonable process is adopted to prepare the traditional Chinese medicine composition, so that the traditional Chinese medicine composition is convenient to use.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets. Background Technology

[0002] Transmissible gastroenteritis (TGE) in pigs is a highly contagious intestinal disease caused by transmissible gastroenteritis virus (TGEV), characterized by vomiting, severe diarrhea, and high mortality (usually 100%) in suckling piglets under two weeks of age. While pigs of different ages are susceptible to TGEV, mortality rates are lower in pigs older than 5 weeks.

[0003] Epidemiology: When TGEV invades pig farms, it often rapidly infects pigs of all ages, especially in winter. Most pigs develop varying degrees of anorexia, vomiting, and diarrhea. Suckling piglets are severely affected, rapidly dehydrating, with high mortality rates in pigs under 2-3 weeks old, although mortality gradually decreases with age. Sows are frequently affected, exhibiting anorexia and agalactia, further contributing to increased mortality in suckling piglets.

[0004] Modern medical treatment for TGE: Transmissible gastroenteritis (TGE) in pigs is a highly contagious intestinal disease caused by the transmissible gastroenteritis virus (TGEV), characterized by vomiting, severe diarrhea, and high mortality in suckling piglets under two weeks of age. Suckling piglets are severely affected, rapidly dehydrated, and have a very high mortality rate, typically 100%, in pigs under 2-3 weeks of age.

[0005] Current methods of treating TGE with Traditional Chinese Medicine / Traditional Chinese Veterinary Medicine:

[0006] Qu Ziming, *A New Compendium of Traditional Chinese Veterinary Medicine Treatments*, Beijing: China Agricultural University Press, December 1993, p. 288: Treatment: Clear heat, detoxify, and stop dysentery. Prescription: Coptis chinensis 10g, Paeonia lactiflora 12g, Pulsatilla chinensis 15g, Sanguisorba officinalis (charred) 12g, Prunus mume 15g, Terminalia chebula 15g, Rheum palmatum 6g, Glycyrrhiza uralensis 12g, Plantago asiatica 12g. Decocted in water and administered orally (dosage for 25kg pigs). (*Handbook for the Prevention and Treatment of Pig Diseases*) Note: This disease is a viral disease, and there is currently no specific and effective treatment. The only method is symptomatic treatment to reduce mortality in suckling piglets, promote early recovery, and provide sufficient clean drinking water containing electrolytes and certain nutrients daily.

[0007] Hu Yuanliang, *A Compilation of Effective Prescriptions and Applications in Traditional Chinese Veterinary Medicine*, Beijing: Chemical Industry Press, June 2019, p. 140: Transmissible Gastroenteritis in Swine.

[0008] Formula 1: Prescription: Coptis chinensis 30g, Prunus mume 30g, Isatis indigotica 15g, Artemisia argyi 15g, Massa fermentata 12g, Smilax glabra 10g, Terminalia chebula 10g, Glycyrrhiza uralensis 30g. Efficacy: Clears heat and detoxifies, dries dampness and stops diarrhea. (Xu Jiayu, Anhui Agricultural Science Bulletin, 2016, 8)

[0009] Formula 2: Prescription: Coptis chinensis 100g, Scutellaria baicalensis 100g, Isatis indigotica 300g, Phellodendron chinense 700g, Rehmannia glutinosa 300g. Efficacy: Clears heat and dries dampness, cools blood and detoxifies. (Dong Juncheng, China Swine Industry, 2008.2)

[0010] Formula 3: Prescription: Coptis chinensis 100g, Phellodendron chinense 100g, Fraxinus chinensis 100g, Magnolia officinalis 100g, Pulsatilla chinensis 200g, Citrus reticulata 150g, Crataegus pinnatifida 200g, Raphanus sativus 150g, Pogostemon cablin 150g, Sanguisorba officinalis (charred) 100g, Agrimonia pilosa 150g, Atractylodes macrocephala 100g, Terminalia chebula 150g, Glycyrrhiza uralensis 50g. Efficacy: Clears heat and dries dampness, strengthens the spleen and stops diarrhea. (Zhao Yingzhen, Journal of Traditional Chinese Veterinary Medicine, 2006.6)

[0011] Currently, the principles or prescriptions for treating TGE in Traditional Chinese Medicine / Traditional Chinese Veterinary Medicine are: clearing heat and detoxifying, clearing heat and drying dampness, and strengthening the spleen and stopping diarrhea. However, in practice, these prescriptions are only suitable for milder cases of TGE in fattening pigs or sows with low mortality rates, and are not effective for more severe cases and higher mortality rates in suckling piglets. They cannot quickly correct dehydration and acidosis in suckling piglets, and despite measures such as enhanced feeding management and environmental disinfection, ideal results have not been achieved in treating TGE in suckling piglets.

[0012] Currently, there are no effective drugs specifically for treating TGE in suckling piglets and reducing the high mortality rate after the onset of TGE in suckling piglets. Therefore, there is an urgent need for a drug that can treat TGE in suckling piglets and solve a major problem in pig production. Summary of the Invention

[0013] Therefore, the present invention provides a traditional Chinese medicine composition for treating transmissible gastroenteritis (TGE) in suckling piglets, which effectively relieves dehydration and acidosis, effectively treats TGE in suckling piglets, and thus reduces mortality.

[0014] This invention provides a traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets, comprising the following components: Adenophora stricta, Adenophora buergeriana, Dendrobium nobile, Polygonatum odoratum, Cornus officinalis, and Ostrea gigas.

[0015] Further, according to the weight parts, it includes the following components: 5-15 parts of South American ginseng, 5-15 parts of North American ginseng, 5-15 parts of Dendrobium, 5-15 parts of Polygonatum odoratum, 5-15 parts of Cornus officinalis, and 10-30 parts of oyster shell.

[0016] Further, according to the weight parts, it includes the following components: 10 parts of South American ginseng, 10 parts of North American ginseng, 10 parts of Dendrobium, 10 parts of Polygonatum odoratum, 10 parts of Cornus officinalis, and 20 parts of oyster shell.

[0017] Furthermore, a method for preparing an oral liquid traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets is characterized by comprising the following steps:

[0018] S1: Weigh the raw materials according to the formula, break the oysters, and soak them in water for 1 hour.

[0019] S2: Mix together the raw materials of South American ginseng, North American ginseng, Dendrobium, Polygonatum odoratum, and Cornus officinalis, and soak in warm water for 1 hour;

[0020] S3: After frying the oysters for 2 hours, add the other 5 ingredients and fry for another hour. Filter to obtain the first original liquid.

[0021] S4: Boil the dregs for another 40 minutes, filter, and obtain the second original liquid;

[0022] S5: Combine the first and second stock solutions, concentrate the filtrate to a relative density of 1.1-1.2 (90℃), add ethanol, refrigerate and let stand, then filter to obtain the third stock solution;

[0023] S6: Recover ethanol from the third original solution filtrate, add water, fill into bottles, and sterilize to obtain the final product.

[0024] Furthermore, in step S5 of the method for preparing traditional Chinese medicine oral liquid according to claim 4, the ethanol content is increased to 65%-75%, and the refrigeration and standing time is 48 hours.

[0025] Furthermore, in step S5 of the method for preparing the oral liquid of traditional Chinese medicine, the filtrate is concentrated to a relative density of 1.17 (90°C).

[0026] Furthermore, in step S6, the ratio of the third original solution filtrate to water is 4:1.

[0027] Furthermore, a method for preparing traditional Chinese medicine granules of a traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets includes the following steps:

[0028] S1: Weigh the raw materials according to the formula, break the oysters, and soak them in water for 1 hour.

[0029] S2: Mix together the raw materials of South American ginseng, North American ginseng, Dendrobium, Polygonatum odoratum, and Cornus officinalis, and soak in warm water for 1 hour;

[0030] S3: After frying the oysters for 2 hours, add the other 5 ingredients and fry for another hour. Filter to obtain the first original liquid.

[0031] S4: Boil the dregs for another 40 minutes, filter, and obtain the second original liquid;

[0032] S5: Combine the first and second stock solutions, and concentrate the filtrate to a relative density of 1.30-1.33 (20℃) to obtain a clear extract;

[0033] S6: Add sugar and dextrin to the clear paste to form granules, then dry them to obtain the final product.

[0034] Furthermore, in step S6 of the method for preparing traditional Chinese medicine granules, the ratio of extract, sugar, and dextrin is 1:2.5:1.

[0035] Furthermore, the dosage form of the traditional Chinese medicine composition is any one of traditional Chinese medicine oral liquid, traditional Chinese medicine granules, traditional Chinese medicine fluid extract, tablets, and capsules.

[0036] Compared with the prior art, the present invention discloses a traditional Chinese medicine composition for treating transmissible gastroenteritis (TGE) in suckling piglets. It uses multiple traditional Chinese medicines as raw materials, including Adenophora stricta, Adenophora buergeriana, Dendrobium nobile, Polygonatum odoratum, Cornus officinalis, and Ostrea gigas. It is prepared by a reasonable process and is convenient to use. This traditional Chinese medicine composition can effectively relieve dehydration and acidosis in the body, effectively treat TGE in suckling piglets, and thus reduce mortality. Detailed Implementation

[0037] To make the objectives and advantages of the present invention clearer, the present invention will be further described below with reference to embodiments; it should be understood that the specific embodiments described herein are merely for explaining the present invention and are not intended to limit the present invention.

[0038] Those skilled in the art should understand that these embodiments are merely for explaining the technical principles of the present invention and are not intended to limit the scope of protection of the present invention.

[0039] It should be noted that in the description of this invention, the terms "upper", "lower", "left", "right", "inner", "outer", etc., indicating directions or positional relationships are based on the directions or positional relationships shown in the specification. This is only for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this invention.

[0040] Furthermore, it should be noted that, in the description of this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0041] A traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets, the formula comprising the following raw material components:

[0042] 10 parts of South American ginseng, 10 parts of North American ginseng, 10 parts of Dendrobium, 10 parts of Polygonatum odoratum, 10 parts of Cornus officinalis, and 20 parts of oyster shell.

[0043] The functions of each active pharmaceutical ingredient in this invention are as follows:

[0044] Southern Adenophora: This product is the dried root of *Adenophora verticillata* or *Adenophora stricta*, plants of the Campanulaceae family. It is harvested in spring and autumn, the fibrous roots are removed, it is washed, the outer skin is scraped off while fresh, washed clean, and then dried. It is sweet and slightly cold in nature, and enters the Lung and Stomach meridians. The following are the main efficacy, uses, and dosage of this raw material:

[0045] Efficacy: Nourishes Yin and clears the lungs, benefits the stomach and promotes the production of body fluids, resolves phlegm, and invigorates Qi;

[0046] Uses: For dry cough due to lung heat, cough due to yin deficiency, dry cough with sticky phlegm, stomach yin deficiency, poor appetite and vomiting, qi and yin deficiency, irritability and dry mouth.

[0047] Dosage and administration: For internal use, decoct 9-15g.

[0048] North American ginseng: The root of *Glehnia littoralis*, a plant in the Apiaceae family. Harvested in July-August or late September, the above-ground stems and fibrous roots are removed, the soil is washed away, the outer skin is peeled off after scalding in boiling water, and then it is sun-dried or oven-dried. It has a sweet taste and cool properties, and its meridian tropism is Lung and Stomach. The following are the main efficacy, uses, and dosage of this raw material:

[0049] Efficacy: Nourishes Yin and clears the lungs; benefits the stomach and promotes the production of body fluids;

[0050] Uses: For dry cough due to lung dryness, cough with blood due to deficiency, stomach yin deficiency, and dryness due to fluid depletion;

[0051] Dosage and administration: For internal use, decoct 5-10g or make into pills, powders, or ointments.

[0052] Dendrobium: The stems of Dendrobium nobile or several other plants of the same genus in the Orchidaceae family. They can be harvested year-round, but those harvested in autumn are of the best quality. If storing fresh Dendrobium after harvesting, it should be planted in fine sand or gravel in spring and autumn, placed in a shady and damp place, and watered frequently to keep the roots moist. In winter, it should be laid flat in a bamboo basket and covered with a straw mat, ensuring good air circulation. Dried Dendrobium is generally made by trimming the fibrous roots of fresh Dendrobium, washing it, and sun-drying or oven-drying it. In Guangxi, it is first scalded with boiling water and then dried while still hot. Rub the edges and sun-dry (or bake) until completely dry; Earring Dendrobium: During processing, select fresh Dendrobium about 4 cm long, trim some of the fibrous roots, wash, and air-dry. Then, put them in an iron pot and stir-fry evenly until soft. While still hot, rub off the thin membrane-like leaf sheaths, place in a ventilated place, and after two days, place them in a lead plate with fine holes. Use a suitable low flame underneath, about one foot away from the plate, to slightly heat them. Bend them by hand into a spiral or spring shape, then air-dry. Repeat this process 2-3 times until completely dry. Taste: sweet; slightly cold; [Meridians] Stomach, Lung, Kidney. The following are the main effects, uses, dosage, and precautions of this raw material:

[0053] Efficacy: Promotes the production of body fluids and benefits the stomach; nourishes yin and clears heat; moistens the lungs and benefits the kidneys; improves eyesight and strengthens the lower back;

[0054] Uses: Primarily for feverish illnesses that damage body fluids; dry mouth and thirst; stomach yin deficiency; stomach pain and dry retching; dry cough due to lung dryness; persistent low-grade fever; blurred vision due to yin deficiency; weakness in the lower back and knees;

[0055] Dosage and administration: For internal use: decoct 6-15g, double the amount for fresh product; or make into pills, powders; or boil into a paste. Fresh Dendrobium has a strong effect in clearing heat and promoting body fluid production, and is suitable for those with heat-induced fluid depletion; dried Dendrobium is suitable for those with stomach deficiency accompanied by heat-induced yin deficiency.

[0056] Precautions: This medication is contraindicated for those in the early stages of febrile diseases before yin deficiency, those with damp-heat diseases before dryness has resolved, and those with spleen and stomach deficiency and cold.

[0057] Polygonatum odoratum: This product is the dried rhizome of Polygonatum odoratum, a plant in the Liliaceae family. It is harvested in autumn, the fibrous roots are removed, it is washed, and sun-dried until soft. Then it is repeatedly rubbed and sun-dried until there is no hard core, and then completely dried; or it is steamed thoroughly, rubbed until translucent, and then sun-dried. It is sweet and slightly cold in nature. [Meridians Entered] Lung and Stomach meridians. The following are the main effects, uses, and dosage of this raw material:

[0058] Efficacy: Nourishes Yin and moistens dryness, promotes body fluid production and quenches thirst;

[0059] Uses: For lung and stomach yin deficiency, dry cough, dry throat and thirst, and internal heat and thirst;

[0060] Dosage and administration: 6-12g.

[0061] Cornus officinalis: This product is the dried, mature fruit pulp of the Cornus officinalis plant (Cornus officinalis). The fruit is harvested in late autumn or early winter when the peel turns red. It is then dried over a low heat or briefly blanched in boiling water, and the pits are removed promptly. It has a sour and astringent taste, and is slightly warm in nature. [Meridians Entered] Liver and Kidney meridians. The following are the main effects, uses, and dosage of this raw material:

[0062] Efficacy: Tonifies the liver and kidneys, astringes and consolidates the body;

[0063] Uses: Used for dizziness and tinnitus, soreness and weakness of the waist and knees, impotence and seminal emission, enuresis and frequent urination, metrorrhagia and leukorrhea, profuse sweating and collapse, internal heat and thirst;

[0064] Dosage and administration: 6-12g.

[0065] Oyster: This product is the shell of the Pacific oyster, Dalian Bay oyster, or oyster of the Ostreidae family. It can be harvested year-round. After removing the meat, wash and dry it. It is salty and slightly cold in nature, and enters the liver, gallbladder, and kidney meridians. The following are the main efficacy, uses, and dosage of this raw material:

[0066] Efficacy: Calms the mind and spirit, nourishes Yin and replenishes Yang, softens hardness and dissipates nodules;

[0067] Uses: For palpitations, insomnia, dizziness, tinnitus, scrofula, phlegm nodules, abdominal masses; calcined oyster shell has astringent and consolidating properties, neutralizes acid and relieves pain; also used for spontaneous sweating, night sweats, seminal emission, metrorrhagia, leukorrhea, stomach pain, and acid regurgitation.

[0068] Dosage and administration: 9-30g, decoct first.

[0069] Example 1

[0070] A traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets, the formula comprising the following raw material components in percentage by weight: 140g of Adenophora stricta, 140g of Adenophora tetraphylla, 140g of Dendrobium nobile, 140g of Polygonatum odoratum, 140g of Cornus officinalis, and 300g of Ostrea gigas.

[0071] The preparation method of the drug combination in Example 1 includes the following steps:

[0072] S1: Weigh the raw materials according to the formula. First, break the oysters and soak them separately in water for 1 hour.

[0073] S2: Mix together the raw materials of South American ginseng, North American ginseng, Dendrobium, Polygonatum odoratum, and Cornus officinalis, and soak in water for 1 hour;

[0074] S3: First, fry the oysters for 2 hours, then add the other 5 ingredients and fry for another hour. Filter to obtain the first original liquid.

[0075] S4: Boil the dregs for another 40 minutes, filter, and obtain the second original liquid;

[0076] S5: Combine the first and second stock solutions, concentrate the filtrate to a relative density of about 1.17 (90℃), add ethanol to make the alcohol content reach 65%-75%, refrigerate and stand for 48 hours, filter to obtain the third stock solution;

[0077] S7: Recover ethanol from the filtrate, add water to adjust to 1000 ml, fill, sterilize, and the product is ready.

[0078] Example 2

[0079] A traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets, the formula comprising the following raw material components in percentage by weight: 140g of Adenophora stricta, 140g of Adenophora tetraphylla, 140g of Dendrobium nobile, 140g of Polygonatum odoratum, 140g of Cornus officinalis, and 300g of Ostrea gigas.

[0080] The preparation method of the drug combination in Example 2 includes the following steps:

[0081] S1: Weigh the raw materials according to the formula. First, break the oysters and soak them separately in water for 1 hour.

[0082] S2: Mix together the raw materials of South American ginseng, North American ginseng, Dendrobium, Polygonatum odoratum, and Cornus officinalis, and soak in water for 1 hour;

[0083] S3: First, fry the oysters for 2 hours, then add the other 5 ingredients and fry for another hour. Filter to obtain the first original liquid.

[0084] S4: Boil the dregs for another 40 minutes, filter, and obtain the second original liquid;

[0085] S5: Combine the first and second stock solutions, concentrate the filtrate to a relative density of 1.31 (20℃), and obtain 222g of clear extract;

[0086] S6: Prepare granules from the extract, sugar, and dextrin in a ratio of 1:2.5:1, and dry them to obtain the final product.

[0087] The following therapeutic trials were conducted to test the performance of the oral liquid of traditional Chinese medicine prepared in Example 1.

[0088] Drug efficacy evaluation trial

[0089] 1. Strengthen feeding management and environmental hygiene

[0090] Ensure good air circulation and purification both inside and outside the farm, keeping it away from farms, slaughterhouses, and waste disposal plants to reduce conditions conducive to infection. Implement immunization programs according to recommended schedules. Thoroughly disinfect all aspects of the farm, including pigsties, premises, personnel, and access routes, using highly effective disinfectants to reduce environmental viral load and infection intensity. Implement sound feeding and management practices, using high-quality, fresh feed ingredients and maintaining suitable temperature and humidity in pigsties to minimize stress from high temperatures, low temperatures, sudden weather changes, and feed changes. Strengthen the control of biological sources such as mosquitoes, flies, and rodents to cut off virus transmission routes. Enhance health care at each growth stage, with a focus on reducing vertical transmission of diseases from sows.

[0091] 2. Treatment measures for sick piglets

[0092] Administer 10 ml of the traditional Chinese medicine oral liquid to each suckling piglet every hour until diarrhea and mortality cease. The control group received intramuscular injections of tylosin at 10 mg / kg body weight twice daily until diarrhea and mortality stopped.

[0093] 3. Experimental Conclusions

[0094] The conclusion shows that this invention has a better therapeutic effect than antibiotics in controlling secondary infections, with a cure rate of over 55%, solving the production problem of a 100% mortality rate in transmissible gastroenteritis (TGE) in suckling piglets. The herbal composition of this invention provides a highly effective, inexpensive, simple, safe, and residue-free treatment for TGE in suckling piglets, and has broad market prospects.

[0095] 4. Results of the treatment trial

[0096]

[0097]

[0098] By studying modern medical understanding of the pathogenesis of transient ischemic attack (TGE) in suckling piglets, and ancient Chinese medical texts on the treatment of diarrhea, dysentery, cholera, and intestinal abscesses, particularly works such as Shan Shujian et al.'s *The Golden Mirror of Clinical Practice of Famous Doctors in Ancient and Modern Times: Diarrhea and Dysentery Volume*, Xiao Donglou's *Handbook for the Prevention and Treatment of Cholera* (6th edition), and Li Qiangou's *Guidelines for the Diagnosis and Treatment of Digestive Diseases in Traditional Chinese Medicine*, this study repeatedly explored the pathogenesis of TGE in suckling piglets. The findings revealed the following pathogenesis: the diarrhea-vomiting stage is a brief period of external invasion of cold and dampness; the main symptom during the dehydration stage is severe diarrhea damaging Yin, leading to Yin deficiency; the transition stage involves Yin deficiency with dampness, Qi and Yin deficiency, Yin deficiency with fire excess, fluid depletion and heat accumulation, a complex mixture of cold and heat, deficiency and excess, and Yin and Yang deficiency. The transition stage is characterized by a series of critical symptoms, severe illness, poor prognosis, and is often considered incurable. Based on the research results on the pathogenesis of TGE in suckling piglets, the key to treatment is to identify the cause through syndrome differentiation and treatment based on the cause, focusing on prescribing medication targeting the main symptom of Yin deficiency during the dehydration stage. This application targets the key points of Yin deficiency and fluid depletion in the pathogenesis of TGE in suckling piglets. It uses a formula composed of Adenophora stricta, Adenophora tetraphylla, Dendrobium nobile, Polygonatum odoratum, Cornus officinalis, and oyster shell, and is prepared using a reasonable process. It is convenient to use and can quickly correct dehydration and acidosis in clinical practice. With the implementation of supporting measures such as enhanced feeding management and environmental disinfection, it has achieved ideal results in the treatment of TGE in suckling piglets, reduced mortality, and has broad application prospects.

[0099] The technical solution of the present invention has been described in conjunction with preferred embodiments. However, it will be readily understood by those skilled in the art that the scope of protection of the present invention is obviously not limited to these specific embodiments. Without departing from the principles of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions resulting from these changes or substitutions will all fall within the scope of protection of the present invention.

[0100] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets, characterized in that... It is composed of the following medicinal materials in parts by weight: 5-15 parts of Adenophora stricta, 5-15 parts of Adenophora buergeriana, 5-15 parts of Dendrobium nobile, 5-15 parts of Polygonatum odoratum, 5-15 parts of Cornus officinalis, and 10-30 parts of Ostrea gigas.

2. The traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to claim 1, characterized in that... The herbal ingredients are composed of the following parts by weight: 10 parts of Adenophora stricta, 10 parts of Adenophora buergeriana, 10 parts of Dendrobium nobile, 10 parts of Polygonatum odoratum, 10 parts of Cornus officinalis, and 20 parts of Ostrea gigas.

3. A method for preparing a traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to any one of claims 1-2, characterized in that, Includes the following steps: S1: Weigh the ingredients according to the formula, break the oysters, and soak them in water for 1 hour; S2: Mix together the raw materials of South American ginseng, North American ginseng, Dendrobium, Polygonatum odoratum, and Cornus officinalis, and soak in warm water for 1 hour. hour; S3: After frying the oysters for 2 hours, add the other 5 ingredients and fry for another hour. Filter to obtain the first original liquid. S4: Boil the dregs again for 40 minutes, filter, and obtain the second original liquid; S5: Combine the first and second stock solutions, concentrate the filtrate to a relative density of 1.1-1.2 at 90℃, add ethanol, refrigerate and let stand, then filter to obtain the third stock solution; S6: Recover ethanol from the third original solution filtrate, add water, fill into bottles, and sterilize to obtain the final product.

4. In step S5 of the preparation method of the traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to claim 3, the ethanol content is 65%-75%, and the refrigeration time is 48 hours.

5. In step S5 of the method for preparing the traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to claim 3, the filtrate is concentrated to a relative density of 1.17 at 90°C.

6. In step S6 of the method for preparing the traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to claim 3, the ratio of the third stock solution filtrate to water is 4:

1.

7. A method for preparing a traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to any one of claims 1-2, characterized in that, Includes the following steps: S1: Weigh the ingredients according to the formula, break the oysters, and soak them in water for 1 hour; S2: Mix together the raw materials of South American ginseng, North American ginseng, Dendrobium, Polygonatum odoratum, and Cornus officinalis, and soak in warm water for 1 hour. S3: After frying the oysters for 2 hours, add the other 5 ingredients and fry for another hour. Filter to obtain the first original liquid. S4: Boil the dregs again for 40 minutes, filter, and obtain the second original liquid; S5: Combine the first and second stock solutions, concentrate the filtrate to a relative density of 1.30-1.33 at 20°C, and obtain a clear extract; S6: Add sugar and dextrin to the clear paste to form granules, then dry them to obtain the final product.

8. In step S6 of the method for preparing the traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to claim 7, the ratio of the extract, sugar, and dextrin is 1:2.5:

1.

9. The traditional Chinese medicine composition for treating transmissible gastroenteritis in suckling piglets according to any one of claims 1-2, characterized in that, The dosage form of the traditional Chinese medicine composition is any one of the following: oral liquid, granules, fluid extract, tablets, or capsules.

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