A traditional Chinese medicine for treating non-alcoholic fatty liver disease of liver-kidney deficiency type

Abstract

The present invention relates to a traditional Chinese medicine for treating non-alcoholic fatty liver disease of the liver-kidney deficiency type, which can effectively solve the problem of medication for treating non-alcoholic fatty liver disease with good curative effect and convenient administration. The traditional Chinese medicine is prepared from the following raw materials by weight: 18-22 g of Rehmannia glutinosa, 14-16 g of Lycium barbarum, 8-10 g of Angelica sinensis, 8-10 g of Glehnia littoralis, 14-16 g of Raphanus sativus, 10-14 g of Cortex Lycii, 9-11 g of Curcuma longa, 25-35 g of Triticum aestivum, 4-6 g of Toosendan fruit and 9-11 g of Glycyrrhiza uralensis. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 30-60 min, then bring to a boil over high heat, and simmer for 30-40 min, filter to obtain the first medicinal liquid; add water to submerge the residue on the drug surface again, bring to a boil over high heat, and simmer for 20-30 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids and mix well. The raw materials of the present invention are rich, the compatibility is scientific and reasonable, the monarch, minister, assistant and envoy are in an orderly manner, and it has the effects of nourishing water to nourish wood, removing vexation and activating blood circulation, reducing lipid and protecting the liver. It is easy to decoct, convenient to take, and has good curative effect.

Description

Technical Field

[0001] The invention relates to medicine, in particular to a traditional Chinese medicine for treating liver and kidney deficiency type non-alcoholic fatty liver disease. Background Art

[0002] The incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing year by year, becoming an important disease that threatens health. NAFLD is a liver disease characterized by fatty degeneration and excessive lipid accumulation in hepatic parenchymal cells, which is often secondary to liver damage caused by non-alcoholic factors. With the different degrees of disease progression, it is divided into four stages: simple fatty liver, fatty liver inflammation, cirrhosis and liver cancer. If the development of NAFLD is not intervened, the harm is very serious. Therefore, it is very important to timely and accurately judge the stage of fatty liver in patients, use targeted drugs, and delay the progression of the disease for the prognosis of fatty liver. Although there are many drugs for the treatment of NAFLD, due to various reasons, their use and efficacy are not satisfactory. Traditional Chinese medicine has the advantages of holistic concept and comprehensive treatment, and the integration of multiple components, multiple targets and multiple pathways. Its role in treating NAFLD is becoming increasingly prominent. Although there are many traditional Chinese medicines for treating non-alcoholic fatty liver disease, their use and efficacy are not satisfactory due to problems with the components, dosage compatibility and preparation methods. Therefore, how to develop an effective traditional Chinese medicine for treating non-alcoholic fatty liver disease is a technical problem that needs to be seriously addressed. Summary of the invention

[0003] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine for treating liver and kidney deficiency type non-alcoholic fatty liver disease, which can effectively solve the problem of medication for treating non-alcoholic fatty liver disease with good efficacy and convenient administration.

[0004] The technical solution solved by the present invention is a traditional Chinese medicine for treating liver and kidney deficiency type non-alcoholic fatty liver disease. The traditional Chinese medicine is prepared from the following raw materials by weight: 18-22g of raw rehmannia root, 14-16g of wolfberry, 8-10g of angelica sinensis, 8-10g of northern adenophora, 14-16g of radish seeds, 10-14g of Chinese wolfberry bark, 9-11g of turmeric, 25-35g of wheat, 4-6g of toosendan seeds and 9-11g of liquorice, wherein the raw materials are first mixed together, immersed in water, soaked at room temperature for 30-60min, then boiled over high heat, boiled over low heat for 30-40min, filtered to obtain a first medicinal liquid; the medicinal residues are immersed in water to cover the medicinal surface, boiled over high heat, boiled over low heat for 20-30min, filtered to obtain a second medicinal liquid; the two medicinal liquids are combined, mixed evenly to form a dose of Chinese medicinal soup, divided equally into two portions, one portion each in the morning and evening, and taken orally warm.

[0005] The raw materials of the present invention are abundant, the compatibility is scientific and reasonable, and the monarch, minister, assistant and guide are in an orderly manner. It has the effects of nourishing the water to nourish the wood, removing vexation and activating blood circulation, reducing lipid and protecting the liver. It is easy to decoct, convenient to take, has good curative effect, and is effectively used for treating non-alcoholic fatty liver disease of liver-kidney deficiency type. It is a major innovation in the drugs for treating non-alcoholic fatty liver disease and has significant economic and social benefits. Detailed implementation mode

[0006] The following combines examples to make a detailed description of the specific implementation mode of the present invention.

[0007] In the specific implementation of the present invention, it can be given by the following examples. Example

[0008] A traditional Chinese medicine for treating non-alcoholic fatty liver disease of liver-kidney deficiency type of the present invention is made from the following raw materials by weight: 20 g of raw rehmannia root, 15 g of wolfberry fruit, 9 g of Chinese angelica, 9 g of Glehnia root, 15 g of radish seed, 12 g of cortex lycii radicis, 10 g of turmeric, 30 g of wheat, 5 g of toosendan fruit and 10 g of liquorice root. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 40 min, then bring to a boil over high heat and simmer for 40 min, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat and simmer for 25 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids, mix well to form a dose of traditional Chinese medicine decoction, divide it into two equal parts, take one part in the morning and one part in the evening, and take it orally at body temperature. Example

[0009] A traditional Chinese medicine for treating non-alcoholic fatty liver disease of liver-kidney deficiency type of the present invention is made from the following raw materials by weight: 18 g of raw rehmannia root, 16 g of wolfberry fruit, 8 g of Chinese angelica, 10 g of Glehnia root, 14 g of radish seed, 14 g of cortex lycii radicis, 9 g of turmeric, 35 g of wheat, 4 g of toosendan fruit and 11 g of liquorice root. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 50 min, then bring to a boil over high heat and simmer for 30 min, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat and simmer for 20 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids, mix well to form a dose of traditional Chinese medicine decoction, divide it into two equal parts. Example

[0010] A traditional Chinese medicine for treating non-alcoholic fatty liver disease of liver-kidney deficiency type, which is made from raw materials by weight: 22g of Rehmannia glutinosa, 14g of Lycium barbarum, 10g of Angelica sinensis, 8g of Glehnia littoralis, 16g of Semen raphani, 10g of Cortex lycii radicis, 11g of Curcuma longa, 25g of Triticum aestivum, 4g of Toosendan fruit and 9g of Glycyrrhiza uralensis. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 30 minutes, then bring to a boil over high heat, and simmer for 40 minutes, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat, and simmer for 30 minutes, filter to obtain the second medicinal liquid; combine the two medicinal liquids, mix well to form a traditional Chinese medicine decoction, and divide it evenly into two portions.

[0011] It should be noted that the technical core and key of the present invention's claimed protection is the compatibility of traditional Chinese medicine components, which can be prepared into decoctions, oral liquids, capsules, powders, pills, or other dosage forms suitable for medical application by using conventional different methods according to different needs.

[0012] Among the above raw material drug components,

[0013] Rehmannia glutinosa: Take the dried medicinal materials, remove impurities, wash, moisten, cut into thick slices, which has the effects of nourishing yin and promoting fluid production, clearing heat and cooling blood;

[0014] Lycium barbarum: Take the original medicinal materials, air-dry until the skin wrinkles, then expose to the sun until the outer skin is dry and hard and the pulp is soft, remove the fruit stalks, which has the effects of tonifying the liver and kidney, replenishing essence and improving eyesight;

[0015] Angelica sinensis: Take the original medicinal materials, remove impurities, wash, moisten thoroughly, remove the fibrous roots, take the Angelica sinensis (main root) part, cut into thin slices, dry in the sun or at low temperature, which has the effects of enriching blood and promoting blood circulation, regulating menstruation and relieving pain;

[0016] Glehnia littoralis: Take the original medicinal materials, remove impurities and residual stems, quickly wash with water, slightly moisten, take out, cut into short sections, dry, which has the effects of nourishing yin and clearing the lung, benefiting the stomach and promoting fluid production;

[0017] Semen raphani: Take the original medicinal materials, remove all impurities, wash, dry, which has the effects of promoting digestion and relieving distension, lowering qi and resolving phlegm;

[0018] Cortex lycii radicis: Remove impurities and residual woody cores, wash, dry in the sun, which has the effects of cooling blood and removing steaming, clearing the lung and reducing fire;

[0019] Curcuma longa: Take the original medicinal materials, remove impurities, separate the large and small ones, wash, moisten thoroughly, cut into thick slices, dry in the sun, which has the effects of promoting blood circulation to remove blood stasis, regulating qi and dredging meridians, relieving pain;

[0020] Triticum aestivum: Harvest when mature, thresh and dry in the sun, which has the effects of benefiting the kidney and nourishing the heart, removing heat and quenching thirst;

[0021] Toosendan fruit: Take the original medicinal materials, pick out impurities, wash, dry in the oven, crush or split into two halves, which has the effects of soothing the liver and regulating qi, relieving pain and expelling worms;

[0022] Licorice: Take the original medicinal material, remove impurities, wash, moisten, cut into thick slices, and dry. It has the effect of clearing away heat and detoxifying, and harmonizing various medicines.

[0023] In the formula, raw Rehmannia root is used heavily to nourish kidney yin, nourish water and contain wood, and it is the main medicine; wolfberry fruit nourishes the kidney and replenishes essence, Angelica sinensis nourishes the liver and nourishes blood, Adenophora adenophora nourishes yin and softens the liver, and Rehmannia root nourishes the liver and kidney, and the three medicines are collectively the ministerial medicine; Radix Rehmanniae is used as an auxiliary medicine to clear heat and cool blood, wheat to calm the mind and relieve restlessness, Toosendan fruit to clear heat and regulate qi, radish seed to descend qi and resolve phlegm, and turmeric to promote blood circulation and resolve blood stasis, and they are the adjuvant medicine; licorice harmonizes all the medicines and is the guiding medicine. Modern pharmacological research shows that: raw earth can resist inflammation and regulate immunity, wolfberry has the effect of lowering blood lipids, angelica (body) and licorice can protect the liver and resist inflammation, northern adenophora and wheat are helpful for anti-inflammatory and lipid-lowering, radish seeds can lower blood lipids, improve obesity and insulin resistance, and ground bone bark and turmeric have anti-inflammatory, lipid-lowering and liver-protecting effects. The combination of these medicines can nourish and soothe the liver, treat the symptoms and the root causes at the same time, and play the effects of nourishing yin and soothing the liver, clearing away heat and eliminating restlessness, promoting blood circulation and removing dampness, and nourishing water and containing wood. It is effectively used to treat non-alcoholic fatty liver disease, and the results have been very good after experiments. The relevant experimental data are as follows:

[0024] 1. Criteria for selecting cases

[0025] Non-alcoholic fatty liver disease (NAFLD) refers to a clinical pathological syndrome characterized by excessive fat deposition in hepatocytes, excluding alcohol and other clear liver-damaging factors, and is an acquired metabolic stress liver injury closely related to insulin resistance and genetic susceptibility. It includes simple fatty liver (SFL), non-alcoholic steatohepatitis (NASH) and related cirrhosis.

[0026] Most patients with fatty liver have no subjective symptoms, but some patients may have non-specific symptoms and signs such as fatigue, indigestion, dull pain in the liver area, hepatosplenomegaly, etc. They may also have symptoms related to metabolic syndrome such as overweight and / or visceral obesity, increased fasting blood sugar, dyslipidemia, and hypertension.

[0027] Patients with the above symptoms and diagnosed with liver and kidney deficiency by traditional Chinese medicine can be used as the criteria for case selection.

[0028] 2. Diagnostic Criteria

[0029] 1. Western medicine diagnostic criteria

[0030] For the selected cases, the relevant diagnostic criteria of the "Guidelines for the Prevention and Treatment of Non-alcoholic Fatty Liver Disease" jointly issued by the Fatty Liver and Alcoholic Liver Disease Group of the Chinese Society of Hepatology in 2018 were adopted: ① No history of alcohol consumption (the alcohol consumption converted to ethanol content is less than 30 g / d for men and less than 20 g / d for women) and other specific causes that can lead to fatty liver (such as taking drugs like amiodarone, methotrexate, tamoxifen, glucocorticoids, etc.); ② Excluding specific diseases that cause fatty liver, such as viral hepatitis, drug-induced liver disease, total parenteral nutrition, Wilson's disease, autoimmune liver disease, etc.; ③ Liver tissue pathological biopsy conforms to the pathological diagnostic criteria of fatty liver disease or imaging examinations (abdominal B-ultrasound, FibroScan, CT examination, liver fat quantification MRI examination) conform to the imaging diagnostic criteria of fatty liver, then it can be diagnosed as non-alcoholic fatty liver disease.

[0031] 2. Diagnostic criteria for TCM syndromes

[0032] For the selected cases, referring to the syndrome differentiation criteria of "TCM Clinical Diagnosis and Treatment Terms", "Clinical Guidelines for New TCM Drugs", and the national planning textbook "Internal Medicine of Traditional Chinese Medicine", the main and secondary symptoms of liver and kidney deficiency were determined according to the pathogenesis characteristics and symptom changes of non-alcoholic fatty liver disease.

[0033] Syndrome of liver and kidney deficiency:

[0034] Main symptom: Discomfort / pain / distending pain in the right hypochondrium.

[0035] Secondary symptoms: Obesity, five centers fever, tidal fever and night sweats, restlessness and insomnia, dry mouth, unsmooth or loose stools, thin and less tongue coating, visible sublingual veins, stringy and thready pulse. Among them, if 2 of the main and secondary symptoms are present, it can be diagnosed as non-alcoholic fatty liver disease, and the traditional Chinese medicine decoction of the present invention is used for treatment.

[0036] III. Treatment plan

[0037] After the treatment starts, take the traditional Chinese medicine decoction of the present invention (taking Example 1 as an example), one dose a day, divided into two equal parts, one part in the morning and one part in the evening, taken orally at body temperature. The curative effect is statistically analyzed for a course of 3 months. After the end of the course, diet therapy, exercise therapy, and TCM characteristic therapy can be combined to consolidate the effect.

[0038] IV. Curative effect evaluation criteria

[0039] It was drawn up with reference to the relevant regulations of the "Guiding Principles for the Research of New TCM Drugs".

[0040] Marked effect: The main symptoms basically disappear, and liver function, blood lipids, and non-invasive detection of liver fibrosis are normal.

[0041] Effective: The main symptoms are relieved, and liver function, blood lipids, and liver color ultrasound are significantly improved compared with before treatment.

[0042] Invalid: There were no obvious changes in the main symptoms, liver function, blood lipids, and liver color ultrasound.

[0043] V. Statistical Analysis

[0044] Among the 97 confirmed non-alcoholic fatty liver disease patients in the outpatient clinic, they took the traditional Chinese medicine decoction of the present invention according to the treatment plan. Among them, 36 cases were markedly effective (37.11%), 48 cases were effective (49.49%), 13 cases were ineffective (13.40%), and the total effective rate was 86.60%.

[0045] VI. Typical Cases

[0046] 1. Case 1

[0047] Patient Chai, female, registration number 0004826674, 60 years old, first diagnosis on August 8, 2022.

[0048] Intermittent right hypochondrium fullness occurred in the past 10 years, and it was felt to be aggravated in the past 2 years, accompanied by dry mouth, fullness in the stomach, especially after eating, mood swings, and poor effect of taking medicine. On July 29, 2022, the liver function test in a local hospital showed that alanine aminotransferase (ALT) was 93 U / L and aspartate aminotransferase (AST) was 59 U / L. On August 8, 2022, the non-invasive liver fibrosis test showed that the CAP value of liver fat detection was 350 dB / m and the liver stiffness value was 6.1 kPa, indicating that liver steatosis was ≥67% and the liver stiffness value was in the F0-F1 stage. Current symptoms: right hypochondrium fullness, dry mouth, fullness in the stomach, unstable mood, frequent yawning, difficulty falling asleep, waking up early and difficult to fall asleep again, normal appetite, loose stools 2 times a day, normal urine. The tongue is dark red, the tongue body is enlarged, the tongue coating is thin and less, the sublingual collaterals are tortuous, and the pulse is thin and astringent. The body type is overweight, likes meat, height is 157 cm, weight is 62.5 kg, and BMI is 25.4. Past history: History of hyperlipidemia for 2 years, not taking medicine; Uterus removed due to uterine fibroids at the age of 48. Western medicine diagnosis: 1. Non-alcoholic fatty liver hepatitis, 2. Perimenopausal syndrome; Traditional Chinese medicine diagnosis: 1. Liver mass (liver and kidney deficiency syndrome), 2. Zangzao. Treatment principle: Tonify the kidney and liver, remove vexation and activate blood circulation, and give Yiguan Ganpi Decoction;

[0049] Second diagnosis on August 22, 2022: The patient reported that after taking the medicine, the distending pain in the hypochondrium, dry mouth, and insomnia were significantly relieved, the fullness in the stomach was slightly reduced, the mood was relatively stable, there was more hot flashes and sweating, the appetite was normal, there were more flatulence, the stools were loose, twice a day, and the urine was normal. The tongue body was enlarged, the tongue was light red, the tongue coating was thin and white, the pulse was deep and thready, and the sublingual collaterals were tortuous. On August 17, 2022, the liver function test in Zhengzhou Central Hospital showed ALT 67 U / L, AST 43 U / L, total bilirubin (TBIL) 12.9 μmol / L, and the blood lipid test showed total cholesterol (GHOL) 5.68 mmol / L, triglyceride (TG) 4.56 mmol / L, high-density lipoprotein (HDL-C) 1.05 mmol / L, and low-density lipoprotein (LDL-C) 3.05 mmol / L. Continue to take 15 doses of the traditional Chinese medicine decoction of the present invention, 1 dose per day, decocted in water, taken warm orally in the morning and evening.

[0050] Third diagnosis on September 5, 2022: The symptoms of distending pain in the hypochondrium, dry mouth, and fullness in the stomach basically disappeared, the sweating decreased, the appetite was normal, there were more dreams and easy to wake up, and the defecation and urination were normal. The tongue was light red, the tongue coating was thin and yellow, the pulse was deep and thready, and the sublingual collaterals were tortuous. The weight was 59 kg, and the BMI was 23.9. Continue to take 20 doses of the traditional Chinese medicine decoction of the present invention, 1 dose per day, decocted in water, taken warm in the morning and evening.

[0051] Follow-up in November 2022: The patient reported that after taking the medicine for the third diagnosis, he continued to take the prescription by himself for 30 doses. After taking the medicine, all symptoms disappeared. The liver function and blood lipid were rechecked locally and were normal. The non-invasive detection of liver fibrosis showed that the CAP value of liver fat detection was 232 dB / m, and the liver stiffness value was 5.2 kPa, indicating that the liver steatosis was <11%, and the liver stiffness value was in the F0 stage. He was instructed to continue to control his weight, maintain a good lifestyle and diet, and take Xiaozhi Hugan Capsules for rehabilitation.

[0052] 2. Case Two

[0053] Patient Gu Mou, male, medical record number 1770, 41 years old, first diagnosis on January 9, 2017.

[0054] There has been intermittent dull pain in both hypochondriac regions for nearly half a year, with the right side being more severe. An ultrasound examination at a local hospital showed severe fatty liver, but no treatment was given. The condition worsened in the past week, so the patient came to our hospital for treatment. On the day of examination, liver function and blood sugar were both normal, triglyceride (TG) was 2.28 mmol / L, and non-invasive liver fibrosis detection showed that the CAP value of liver fat detection was 273 dB / m, and the liver stiffness value was 5.5 kPa, indicating that liver steatosis was ≥34%, and the liver stiffness value was in the F0-F1 stage. Current symptoms: pain in both hypochondriac regions, soreness and weakness in both knees, irritability, excessive sweating at night, slightly short of breath, normal appetite and sleep, loose stools 2-3 times a day, and normal urination. The tongue is pale and dull, the tongue body is enlarged, the tongue coating is white and greasy, the sublingual collaterals are revealed, and the pulse is deep and thready. The patient is overweight, 178 cm tall, weighs 97 kg, BMI is 30.6, and the waist circumference is 2 feet 9. Past history: hyperlipidemia for 1 year, no medication; radiation exposure work history 5 years ago. Western medicine diagnosis: non-alcoholic fatty liver disease; Traditional Chinese medicine diagnosis: 1. Liver mass (syndrome of deficiency of liver and kidney). The treatment principle is to tonify the kidney and nourish the liver, remove vexation and activate blood circulation. The patient was given 14 doses of the Yiguan Ganpi Decoction of the present invention, 1 dose per day, decocted in water for oral administration, taken warm in the morning and evening.

[0055] Second visit on January 25, 2017: After taking the medicine, the soreness in the knees and night sweats were significantly relieved, but the patient still complained of hypochondriac pain and irritability. Appetite and sleep were normal, loose stools 2-3 times a day, and urination was normal. The tongue was dark red, the tongue body was enlarged, the tongue coating was thin and white, the sublingual collaterals were revealed, and the pulse was deep and thready. Prescription: Continue to take the first visit prescription for 20 doses, 1 dose per day, decocted in water for oral administration, taken warm in the morning and evening.

[0056] Third visit on February 13, 2017: The effect was acceptable after taking the medicine, but there was still pain in both hypochondriac regions, and the rest was the same as before. The tongue was dark red, the tongue body was enlarged, the tongue coating was thin and white, the sublingual collaterals were revealed, and the pulse was deep and thready. Weight was 93 kg, and waist circumference was 2 feet 7. Prescription: Continue to take for 30 doses, 1 dose per day, decocted in water for oral administration, taken warm in the morning and evening.

[0057] Fourth visit on March 15, 2017: There was no obvious discomfort after taking the medicine. The tongue was light red, the tongue body was enlarged, the tongue coating was thin and white, the sublingual collaterals were slightly revealed, and the pulse was deep and thready. The weight decreased by 13 Kg compared with the first visit, and the current weight was 87 Kg, and the waist circumference was 2 feet 6. Liver function, blood sugar, and blood lipids were all normal. Non-invasive liver fibrosis detection showed that the CAP value of liver fat detection was 241 dB / m, and the liver stiffness value was 5.1 kPa, indicating that liver steatosis was ≥11%, and the liver stiffness value was in the F0-F1 stage. Keep the prescription and continue to take for 30 doses. Instruct the patient to strengthen exercise and control diet.

[0058] Telephone follow-up on May 10, 2017: The patient reported no obvious discomfort, the weight decreased to 82 Kg, the mood was comfortable, and an ultrasound examination at the local hospital showed mild fatty liver. Instruct the patient to continue to lose weight and take Xiaozhi Hugan Capsules and Natural Vitamin E Capsules for follow-up treatment.

[0059] It should be pointed out that the present invention can also make additions and subtractions in components and dosages according to different symptoms associated with the patient on the basis of following the composition combination, which is essentially no different from the components of the present invention and all fall within the scope of protection of the present invention.

[0060] While conducting experiments on Example 1, the same experiments were also conducted on other examples, and the same or similar results were obtained, which will not be described in detail here.

[0061] VII. Conclusion

[0062] From the above experimental data, we can see that the pathogenesis of non-alcoholic fatty liver disease is complex. Western medicine has not yet made clear research on it, and there is no specific medicine for clinical treatment. Traditional Chinese medicine's understanding of non-alcoholic fatty liver disease is gradually deepening, but the clinical classification of the disease is limited to empirical evidence, and there is actually a liver and kidney deficiency type in clinical practice.

[0063] According to traditional Chinese medicine, when qi and blood are weak and kidney essence is deficient, it is easy to have the phenomenon of "water not containing wood", which leads to liver wood not being nourished, failure of dispersing and discharging, and failure of blood storage. When the liver fails to dispersing and discharging, it cannot help the spleen to transport water and dampness, and water and dampness stagnate and produce phlegm and turbidity; dampness and turbidity block the qi, blood circulation is not smooth, and blood stasis gradually occurs, resulting in yin deficiency, qi stagnation, phlegm and turbidity blocking the liver network, and developing liver disease. Therefore, kidney essence deficiency and water not containing wood are the basic pathogenesis of liver and kidney deficiency type non-alcoholic fatty liver disease, and phlegm, turbidity and stasis are its pathological products. Therefore, the disease is located in the liver and is closely related to kidney deficiency. Kidney essence deficiency and liver failure of dispersing and discharging are the root, and phlegm and turbidity are the symptoms. The disease is deficiency in the root and excess in the symptoms.

[0064] The Chinese medicine of the invention is rich in raw materials, has scientific and reasonable compatibility, and has orderly rules of monarch, minister, adjuvant and guiding. It has the effects of nourishing water and wood, eliminating restlessness and activating blood circulation, lowering fat and protecting the liver. It is easy to decoct, convenient to take, has good efficacy, and has no obvious toxic and side effects. It is effectively used for treating liver and kidney deficiency type non-alcoholic fatty liver disease, with an effective rate of 86.6%. It has strong clinical application value, is a major innovation in drugs for treating non-alcoholic fatty liver disease, and has significant economic and social benefits.

Claims

1. A traditional Chinese medicine composition for treating non-alcoholic fatty liver disease of liver-kidney deficiency type, characterized in that, The traditional Chinese medicine composition is prepared from the following raw materials by weight: 18 - 22 g of Rehmannia glutinosa, 14 - 16 g of Lycium barbarum, 8 - 10 g of Angelica sinensis, 8 - 10 g of Glehnia littoralis, 14 - 16 g of Raphanus sativus, 10 - 14 g of Cortex Lycii, 9 - 11 g of Curcuma longa, 25 - 35 g of Triticum aestivum, 4 - 6 g of Toosendan fruit, and 9 - 11 g of Glycyrrhiza uralensis. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 30 - 60 min, then bring to a boil over high heat, and simmer for 30 - 40 min, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat, and simmer for 20 - 30 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids and mix well to obtain the said traditional Chinese medicine composition.

2. The traditional Chinese medicine composition for treating non-alcoholic fatty liver disease of liver-kidney deficiency type according to claim 1, wherein, The traditional Chinese medicine composition is prepared from the following raw materials by weight: 20 g of Rehmannia glutinosa, 15 g of Lycium barbarum, 9 g of Angelica sinensis, 9 g of Glehnia littoralis, 15 g of Raphanus sativus, 12 g of Cortex Lycii, 10 g of Curcuma longa, 30 g of Triticum aestivum, 5 g of Toosendan fruit, and 10 g of Glycyrrhiza uralensis. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 40 min, then bring to a boil over high heat, and simmer for 40 min, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat, and simmer for 25 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids and mix well to obtain the said traditional Chinese medicine composition.

3. The traditional Chinese medicine composition for treating non-alcoholic fatty liver disease of liver-kidney deficiency type according to claim 1, wherein The traditional Chinese medicine composition is prepared from the following raw materials by weight: 18 g of Rehmannia glutinosa, 16 g of Lycium barbarum, 8 g of Angelica sinensis, 10 g of Glehnia littoralis, 14 g of Raphanus sativus, 14 g of Cortex Lycii, 9 g of Curcuma longa, 35 g of Triticum aestivum, 4 g of Toosendan fruit, and 11 g of Glycyrrhiza uralensis. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 50 min, then bring to a boil over high heat, and simmer for 30 min, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat, and simmer for 20 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids and mix well to obtain the said traditional Chinese medicine composition.

4. The traditional Chinese medicine composition for treating non-alcoholic fatty liver disease of liver-kidney deficiency type according to claim 1, wherein, The traditional Chinese medicine composition is prepared from the following raw materials by weight: 22 g of Rehmannia glutinosa, 14 g of Lycium barbarum, 10 g of Angelica sinensis, 8 g of Glehnia littoralis, 16 g of Raphanus sativus, 10 g of Cortex Lycii, 11 g of Curcuma longa, 25 g of Triticum aestivum, 4 g of Toosendan fruit, and 9 g of Glycyrrhiza uralensis. Among them, first mix the raw materials together, add water to submerge them, soak at room temperature for 30 min, then bring to a boil over high heat, and simmer for 40 min, filter to obtain the first medicinal liquid; add water to submerge the residue again, bring to a boil over high heat, and simmer for 30 min, filter to obtain the second medicinal liquid; combine the two medicinal liquids and mix well to obtain the said traditional Chinese medicine composition.