Qi Zao Oral Liquid for Treating Infantile Anorexia and Its Preparation Method

Abstract

The present invention discloses a Qi-Zao oral liquid for treating infantile anorexia, which is prepared by extracting the following raw medicinal materials in parts by weight: 6-10 parts of wolfberry fruit, 8-12 parts of Chinese date, 5-10 parts of Codonopsis pilosula, 6-10 parts of prepared rehmannia root, 8-12 parts of dried tangerine peel, 10-14 parts of Atractylodes macrocephala, 4-8 parts of Scutellaria baicalensis, 6-10 parts of gardenia fruit, 10-14 parts of stir-fried hawthorn fruit, 8-12 parts of medicated leaven, 6-10 parts of dried gallus stomach membrane, 8-12 parts of semen raphani, 6-10 parts of polygonatum odoratum, 5-10 parts of smoked plum, 6-10 parts of Glehnia littoralis, 6-10 parts of Ophiopogon japonicus, 10-14 parts of fingered citron, 6-10 parts of amomum villosum. It can invigorate the spleen and kidney, soothe the liver and strengthen the spleen, eliminate accumulation and clear heat, promote digestion and guide stagnation, nourish the stomach and yin, nourish the lung yin, promote qi movement and invigorate the spleen. They are commonly formulated to treat infantile anorexia of the type of deficiency of the spleen and kidney, achieving very good effects, and the preparation method thereof is also disclosed.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a Qi-Zao oral liquid for treating infantile anorexia and a preparation method thereof. Background Art

[0002] Infantile anorexia is also called digestive function disorder, which generally occurs easily in babies aged 3 to 6 years old. It is a disease mainly characterized by long-term loss of appetite or lack of appetite. Children suffering from anorexia often have poor appetite, and often vomit, have diarrhea, constipation, and even abdominal pain and bloody stools.

[0003] Traditional Chinese medicine believes that the main factors causing infantile anorexia are as follows: First, improper diet, which damages the spleen and stomach. Infants cannot regulate their own milk intake, and do not know when to be hungry or full. Parents spoil their children too much and indulge their partial eating and preference, resulting in the failure of the spleen to transport and the stomach to descend harmoniously, leading to anorexia. Second, overeating raw and cold foods, which injures the spleen yang, traps the spleen by cold-dampness, obstructs the middle-jiao, affects reception and transportation, and leads to anorexia. Third, improper nursing, resulting in insufficient stomach yin. Children are in a state of delicate yin and yang, with delicate viscera and insufficient form and qi, and poor resistance to diseases. Coupled with their inability to regulate cold and warmth by themselves, once the nursing is improper, they are easily injured by exogenous pathogens and fall ill. Especially after febrile diseases, body fluids are consumed, dryness-heat injures the stomach yin, or mistakenly use warming and tonifying methods, which helps heat to injure yin. Insufficient stomach yin leads to abnormal reception and transportation, resulting in aversion to eating. The Qi-Zao oral liquid produced by our company is composed of wolfberry fruit, sea cucumber, heterophylly falsestarwort root, Chinese date, pearl, semen alpina oxyphyllae, and hawthorn fruit. It has the effects of tonifying the kidney, strengthening the spleen and stomach, replenishing qi and nourishing blood, and promoting digestion and removing food stagnation. It is used to treat severely anorectic children with spleen-kidney deficiency, such as listlessness, poor appetite, sallow complexion, memory loss, slow growth and development, night sweats, and rickets caused by anorexia. After years of application, there are many problems such as poor taste of the oral liquid, fishy smell, insufficient drug loading, and unclear syndrome types. Summary of the Invention

[0004] To solve the deficiencies of the prior art, the purpose of the present invention is to provide a Qi-Zao oral liquid for treating infantile anorexia and a preparation method thereof. The traditional Chinese medicine preparation for treating infantile anorexia provided by the present invention has a good effect on treating infantile anorexia. The present invention has definite curative effect, clear syndrome type, good taste, simple preparation process, strong operability, relatively stable preparation product, easy control of preparation conditions, simple operation, and is easy for large-scale production.

[0005] A Qi-Zao oral liquid for treating infantile anorexia is prepared by extracting the following raw medicinal materials in parts by weight: 6-10 parts of Chinese wolfberry, 8-12 parts of Chinese date, 5-10 parts of Codonopsis pilosula, 6-10 parts of prepared rehmannia root, 8-12 parts of dried tangerine peel, 10-14 parts of Atractylodes macrocephala, 4-8 parts of Scutellaria baicalensis, 6-10 parts of Gardenia jasminoides, 10-14 parts of stir-fried hawthorn fruit, 8-12 parts of medicated leaven, 6-10 parts of chicken's gizzard-membrane, 8-12 parts of radish seed, 6-10 parts of polygonatum odoratum, 5-10 parts of smoked plum, 6-10 parts of Glehnia littoralis, 6-10 parts of Ophiopogon japonicus, 10-14 parts of fingered citron, 6-10 parts of amomum villosum.

[0006] The Qi-Zao oral liquid for treating infantile anorexia is prepared by extracting the following raw medicinal materials in parts by weight: 8 parts of Chinese wolfberry, 10 parts of Chinese date, 7 parts of Codonopsis pilosula, 8 parts of prepared rehmannia root, 10 parts of dried tangerine peel, 12 parts of Atractylodes macrocephala, 6 parts of Scutellaria baicalensis, 8 parts of Gardenia jasminoides, 12 parts of stir-fried hawthorn fruit, 10 parts of medicated leaven, 8 parts of chicken's gizzard-membrane, 10 parts of radish seed, 8 parts of polygonatum odoratum, 7 parts of smoked plum, 8 parts of Glehnia littoralis, 8 parts of Ophiopogon japonicus, 12 parts of fingered citron, 8 parts of amomum villosum.

[0007] The preparation method of the Qi-Zao oral liquid for treating infantile anorexia comprises the following steps:

[0008] (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush and mix them evenly to obtain a traditional Chinese medicine mixture;

[0009] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, each time adding water in an amount 8-15 times the weight of the traditional Chinese medicine mixture, decocting for 1-3 hours each time, combine the three decoctions, filter to obtain a filtrate;

[0010] (3) Concentrate the filtrate obtained in step (2) into a clear paste with a relative density of 1.05-1.15, the concentration temperature is up to 80 °C, add ethanol to it until the volume percentage of ethanol is 60%-80%, stir, let stand for 12-24 hours, filter, recover the ethanol under reduced pressure from the obtained filtrate, concentrate to a relative density of 1.25-1.30 at 50 °C to obtain a concentrated solution, add a flavoring agent to prepare an oral liquid.

[0011] The preparation method of the Qi-Zao oral liquid for treating infantile anorexia comprises the following steps:

[0012] (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush and mix them evenly to obtain a traditional Chinese medicine mixture;

[0013] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, each time adding water in an amount 12 times the weight of the traditional Chinese medicine mixture, decocting for 2 hours each time, combine the three decoctions, filter to obtain a filtrate;

[0014] (3) Concentrating the filtrate obtained in step (2) into a clear paste with a relative density of 1.10, the concentration temperature is increased to 80° C., ethanol is added thereto until the volume percentage of ethanol is 70%, the mixture is stirred, allowed to stand for 18 hours, filtered, and the filtrate is decompressed to recover ethanol. When the filtrate is concentrated to 50° C., the relative density is 1.28, and a concentrated solution is obtained. A flavoring agent is added to prepare an oral solution.

[0015] The Qizao oral liquid for treating anorexia in children is used in preparing medicines for treating anorexia in children.

[0016] The Qizao oral liquid for treating anorexia in children is used in the preparation of medicines for treating anorexia in children, wherein anorexia in children is a syndrome of spleen and kidney deficiency.

[0017] Wolfberry is the mature fruit of Lycium barbarum or Lycium chinense of the Solanaceae family. The fruit is picked when it is ripe in summer and autumn, the fruit stalk is removed, and it is placed in a cool place to dry until the skin wrinkles, and then exposed to the sun until the skin is dry and hard and the flesh is soft. It can be dried over a low fire when it rains. The main functions are to nourish the kidney, moisten the lungs, nourish the liver, and improve eyesight. It can treat liver and kidney yin deficiency, soreness of the waist and knees, dizziness, vertigo, blurred vision and excessive tears, consumptive cough, thirst, and spermatorrhea.

[0018] Jujube is the mature fruit of the plant jujube of the Rhamnaceae family. It is harvested in autumn when the fruit is ripe, and the impurities are picked out and dried in the sun; or baked until the skin is soft, and then dried in the sun; or boiled in water to make the flesh soft and the skin not wrinkled, then picked up and dried in the sun. Functions and indications: tonify the spleen and stomach, replenish qi and produce body fluid, regulate the body's defense system, and detoxify drugs. It can treat poor appetite due to weak stomach, loose stools due to weak spleen, insufficient qi, blood and body fluid, disharmony between the body's defense system, palpitations, and impatience in women.

[0019] Codonopsis is the dried root of Codonopsis pilosula, Codonopsis pilosula, or Codonopsis pilosula of the Campanulaceae family. Codonopsis pilosula is sweet and neutral in nature. It can nourish the middle qi, quench thirst, strengthen the spleen and benefit the lungs, nourish blood and produce body fluid. It is used for spleen and lung qi deficiency, fatigue due to poor appetite, cough and asthma, insufficient qi and blood, sallow complexion, palpitations and shortness of breath, thirst due to loss of body fluid, and internal heat and thirst. It is used for lazy speech, shortness of breath, weakness in the limbs, poor appetite, qi deficiency, deficiency of both qi and body fluid, deficiency of both qi and blood, and sallow complexion due to blood deficiency. However, it cannot be used for those with superficial symptoms that have not been resolved and fullness and evil in the middle. The efficacy of this product is similar to that of ginseng, but the medicinal power is weak. It can be used instead of ginseng for general deficiency syndrome; for severe prostration, ginseng is still suitable. Dig it up in autumn, wash it, and dry it in the sun.

[0020] Rehmannia glutinosa is the rhizome of Rehmannia glutinosa or Rehmannia glutinosa of the Scrophulariaceae family, which is processed, steamed and dried. It has the functions of nourishing yin and blood. It can treat yin deficiency and blood deficiency, weakness of waist and knees, fatigue cough and bone steaming, spermatorrhea, metrorrhagia, irregular menstruation, thirst, frequent urination, deafness and blurred vision.

[0021] Tangerine peel is the dried mature pericarp of the plant Citrus reticulata Blanco of the Rutaceae family and its cultivated varieties. The medicinal materials are divided into "tangerine peel" and "Guangdong tangerine peel". The mature fruits are picked, the pericarp is peeled off, and dried in the sun or by low-temperature drying. It is bitter, pungent, and warm in nature. It belongs to the lung and spleen meridians. It regulates qi and strengthens the spleen, dries dampness and resolves phlegm. It is used for abdominal distension, poor appetite, vomiting and diarrhea, and excessive cough with phlegm.

[0022] Atractylodes macrocephala Koidz. is the dried rhizome of the plant Atractylodes macrocephala Koidz. of the Asteraceae family. It is dug when the lower leaves turn yellow and withered and the upper leaves become brittle in winter. After removing the sediment, it is dried by baking or in the sun, and then the fibrous roots are removed. It belongs to the spleen and stomach meridians. It is bitter, sweet, and warm. It strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and prevents miscarriage. It is used for poor appetite due to spleen deficiency, abdominal distension and diarrhea, dizziness and palpitation due to phlegm-fluid retention, edema, spontaneous sweating, and restlessness during pregnancy. Stir-fried Atractylodes macrocephala strengthens the spleen, harmonizes the stomach, and prevents miscarriage. It is used for poor appetite due to spleen deficiency, loose stools, and restlessness during pregnancy.

[0023] Scutellaria baicalensis Georgi is a perennial herb of the genus Scutellaria in the Lamiaceae family; its fleshy rhizome is thick, the leaves are firmly papery, lanceolate to linear-lanceolate, the raceme is terminal on the stem and branches, the corolla is purple, purplish-red to blue, the filaments are flat, the style is slender, the disc is annular, the ovary is brown, and the nutlets are ovoid. The flowering and fruiting period is from July to September. Scutellaria baicalensis Georgi grows on sunny grassy slopes at an altitude of 60 - 1300 (1700 - 2000) meters. It is produced in Heilongjiang, Liaoning, Inner Mongolia, Hebei, Henan, Gansu, Shaanxi, Shanxi, Shandong, Sichuan and other places, and can be planted in most northern provinces of China. Its root is used as medicine, which is bitter and cold in nature, and has the effects of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding, and preventing miscarriage. It is mainly used to treat febrile diseases, upper respiratory tract infections, cough due to lung heat, damp-heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, restlessness during pregnancy, hypertension, carbuncles and furuncles, etc.

[0024] Gardenia jasminoides Ellis is the fruit of the plant Gardenia jasminoides Ellis of the Rubiaceae family. The fruit of Gardenia jasminoides Ellis is a traditional Chinese medicine and belongs to the first batch of dual-purpose resources of medicine and food promulgated by the Ministry of Health. It has the effects of protecting the liver, promoting bile secretion, reducing blood pressure, sedation, stopping bleeding, and detumescence. It is commonly used in traditional Chinese medicine clinics to treat jaundice hepatitis, sprains and contusions, hypertension, diabetes, etc.

[0025] Fried Hawthorn Fruit is the product of the fruit of the plant Crataegus pinnatifida Bunge of the Rosaceae family and is a commonly used Chinese medicinal material. The main processing methods are stir-frying until yellow, stir-frying until charred, and stir-frying until carbonized. Mature hawthorn fruits are taken, impurities, fallen pits and fruit stalks are removed, sliced and placed in a pot, heated with medium heat until the surface is dark brown and the inside is yellowish-brown, with a fragrant smell, sour and slightly astringent taste. Hawthorn itself has the functions of promoting digestion and strengthening the stomach, promoting qi circulation and removing stasis, and reducing turbidity and lipid. After being made into Fried Hawthorn Fruit, not only the sour taste is weakened, but also the bitter taste is increased. It is good at promoting digestion and relieving diarrhea, and is commonly used for food retention accompanied by spleen deficiency and dysentery, such as Baohe Pills for treating food retention.

[0026] Shenqu is a medicinal leaven made by fermenting Polygonum hydropiper, Artemisia annua, almond paste, adzuki beans, fresh Xanthium sibiricum with flour or wheat bran. It is sweet, pungent, and warm in nature, acting on the spleen and stomach meridians. It can invigorate the spleen and harmonize the stomach, promote digestion and resolve food stagnation. It is used for food stagnation, indigestion, abdominal distension, loss of appetite, vomiting and diarrhea.

[0027] Endothelium Corneum Gigeriae Galli is the dried inner wall of the gizzard of the chicken (Gallus gallus domesticus Brisson) of the Phasianidae family. After slaughtering the chicken, take out the gizzard, immediately peel off the inner wall, wash it, and dry it. It is sweet and neutral in nature, acting on the spleen, stomach, small intestine, and bladder meridians. It can promote digestion, astringe essence and stop enuresis, and remove calculus and promote diuresis. It is used for indigestion, vomiting and diarrhea, infantile malnutrition, enuresis, spermatorrhea, stranguria with pain, and hypochondriac pain due to gallbladder distension.

[0028] Semen Raphani is the dried ripe seeds of the radish (Raphanus sativus L.) of the Brassicaceae family. When the fruits are ripe in summer, cut the plants and dry them in the sun. Rub out the seeds, remove the impurities, and then dry them again. It is pungent, sweet, and neutral in nature, acting on the lung, spleen, and stomach meridians. It can promote digestion and relieve distension, lower qi and resolve phlegm. It is used for food stagnation, abdominal distension and pain, constipation, diarrhea due to food retention, and cough and asthma due to phlegm congestion.

[0029] Rhizoma Polygonati Odorati is the dried rhizome of the Polygonatum odoratum (Mill.) Druce of the Liliaceae family. It is distributed in Heilongjiang, Jilin, Liaoning, Hebei, Shanxi, Inner Mongolia, Gansu, Qinghai, Shandong, Henan, Hubei, Hunan, Anhui, Jiangxi, Zhejiang, Jiangsu, Taiwan and other places. It has the effects of nourishing yin and moistening dryness, promoting the production of body fluid and quenching thirst. It is commonly used for yin injury of the lung and stomach, dry cough due to heat dryness, dry throat and thirst, and internal heat with polydipsia.

[0030] Fructus Mume is the dried nearly ripe fruit of the Prunus mume Siebold & Zucc. of the Rosaceae family. It is cultivated all over China, with the most in the provinces south of the Yangtze River. It has the effects of astringing the lung, astringing the intestine, promoting the production of body fluid, and expelling ascaris. It is commonly used for chronic cough due to lung deficiency, chronic diarrhea and dysentery, consumptive fever with thirst, and vomiting and abdominal pain due to ascaris syncope.

[0031] Radix Glehniae is the root of Glehnia littoralis of the Umbelliferae family. It is dug in July - August or late September, remove the above - ground stems and fibrous roots, wash the soil, scald in boiling water and then peel off the outer skin, and dry in the sun or by baking. Its functions and indications are: nourishing yin and moistening the lung, resolving phlegm and relieving cough. It is used to treat dry cough due to lung heat, chronic cough due to consumptive disease, dry throat and thirst due to yin injury. ① "New Compilation of Materia Medica": It specifically nourishes the lung yin, clears lung fire, and treats chronic cough and pulmonary atrophy. ② "Newly Revised Prepared Slices of Chinese Materia Medica": It nourishes the yin of the lung and stomach, and treats hemoptysis due to consumptive disease. ③ "Flora of Northeast China": It treats chronic bronchitis, pulmonary tuberculosis, atelectasis of the lung, lung abscess, etc. ④ "Chinese Materia Medica": It nourishes the lung yin, clears lung heat, resolves phlegm and relieves cough. It treats consumptive fever, dry cough due to yin injury, dry throat and thirst.

[0032] Ophiopogon japonicus is the dried root of Ophiopogon japonicus (Ophiopogon japonicus) of the Liliaceae family. Its functions and indications are: nourishing yin and promoting body fluid, moistening the lungs and relieving coughs: used for symptoms of thirst, dry cough and hemoptysis caused by deficiency of lung and stomach yin; palpitations and easy fright caused by deficiency of heart yin, and damage to body fluids caused by heat in the late stage of fever. It can be used with Adenophora scabra and Fritillaria cirrhosa to treat dry cough caused by deficiency of lung yin.

[0033] Buddha's hand is the dried fruit of Citrusmedica Lvar.sarcodac-tylis Swingle, a plant of the Rutaceae family. The fruit is harvested in autumn before or when it turns yellow, cut into thin slices, and dried in the sun or at low temperature. It tastes pungent, bitter, and sour, and is warm in nature. It enters the liver, spleen, stomach, and lung meridians. It soothes the liver and regulates qi, harmonizes the stomach and relieves pain, and dries dampness and resolves phlegm. It is used for liver and stomach qi stagnation, chest and flank distension and pain, fullness in the stomach, loss of appetite and vomiting, and cough with excessive phlegm.

[0034] Amomum villosum Lour., Amomum villosum Lour. var. xanthioides TLWu et Senjen or Amomum longiligulare TLWu, all of the Zingiberaceae family. The fruits are harvested in summer and autumn when they are ripe, and then dried in the sun or at low temperature. It is pungent and warm in nature. It is good for the spleen, stomach and kidney meridians. It has the effects of removing dampness and stimulating appetite, warming the spleen and stopping diarrhea, regulating qi and calming the fetus. It is used for dampness and turbidity blocking the middle part of the body, abdominal distension without hunger, spleen and stomach deficiency and cold, vomiting and diarrhea, nausea during pregnancy and restless fetus.

[0035] The main site of anorexia in children with spleen and kidney deficiency involves the spleen and stomach. If the diagnosis and treatment are delayed or not cured for a long time, the patient will not gain weight, grow slowly, and develop secondary malnutrition, anemia, malnutrition, rickets, etc. The disease will gradually affect the kidneys, showing the signs of spleen and kidney deficiency. Anorexia symptoms of spleen and kidney deficiency: no appetite, indigestion, loose stools with undigested food, pale complexion, thin body, fatigue, sparse and dull hair, chicken chest and turtle back, developmental delay, pale tongue, fat, or with tooth marks, red tongue, less tongue coating, weak pulse. Children's internal organs are delicate, their physical form and qi are not full, and they have the physiological characteristics of "spleen deficiency" and "kidney deficiency". "The Treatise on the Origin and Symptoms of Various Diseases·Spleen and Stomach Diseases·Spleen and Stomach Qi Weakness and Inability to Eat and Drink" states: "The spleen is an internal organ, and the stomach is an internal organ. The spleen and stomach qi are the exterior and interior. The stomach is the sea of water and grain, and is responsible for receiving and drinking. If the spleen qi is polished and digested, then the child can eat. Now the spleen and stomach qi are both weak, so the child cannot eat and drink." It is necessary to nourish the spleen and kidney. However, children's internal organs are delicate, and their spleen qi is insufficient. It is easy for improper diet and invasion of external evil to cause spleen and stomach weakness, spleen and stomach dysfunction, liver qi reversal, so that the child does not want to eat, accumulates and turns into heat, and the soil is weak, so the wood is hyperactive, so the liver is hyperactive, forming the liver hyperactivity spleen deficiency syndrome. Invigorate the qi and strengthen the spleen, help the movement and wake up the stomach, but do not blindly block the tonification, because its transportation and transformation power is originally weak, and excessive supplementation will hinder the stomach and aggravate the symptoms. It is advisable to supplement the movement and transportation at the same time. Therefore, while nourishing the spleen and kidney, soothe the liver and strengthen the spleen.

[0036] "The Secrets of Raising Children Hidden in the Wanshi Family · Treatment of Food Injury Syndrome" states: "Among children's diseases, food injury is the most common. Therefore, when milk and food stay in the middle jiao and do not digest, resulting in illness, there will be fever, aversion to food, or belching with sour taste, or aversion to the smell of food, or the urge to vomit but not being able to, or vomiting sour gas, or shortness of breath and stuffiness, or abdominal pain and crying. All these are food injury." Food injury often occurs in children with anorexia due to spleen and kidney deficiency. Therefore, it is necessary to eliminate indigestion and clear heat.

[0037] In children with anorexia due to spleen and kidney deficiency, the spleen and stomach fail to perform their transportation and transformation functions properly. They are sometimes full and sometimes hungry, and do not know the taste of food. Food stagnates, and over time, it turns into heat. The accumulated heat blocks the spleen and stomach, leading to unsmooth qi movement, resulting in anorexia. It is also necessary to promote digestion and remove stagnation, relieve distension caused by food stagnation, and induce defecation to relieve constipation.

[0038] In addition, "when deficiency is treated by tonifying its mother, and excess is treated by reducing its child" (from "Difficult Classic · Difficult Issue 69"). The lung generates the kidney, that is, metal generates water. For example, the essence and fluid of the lung descend to nourish the kidney essence, and the lung qi descends to assist the kidney in receiving qi. At the same time, the lung restricts the liver, that is, metal restricts wood. For example, when the lung qi is clear and purified, it can inhibit the hyperactivity of the liver yang, achieving the purpose of soothing the liver and strengthening the spleen. Therefore, tonifying the lung yin can help nourish the kidney and improve the deficiency of both the spleen and the kidney.

[0039] Long-term deficiency of the spleen and kidney consumes the yin fluid, resulting in insufficient stomach yin. The insufficient stomach yin cannot assist the spleen qi in dispersing essence, leading to disharmony of the stomach qi and failure of the spleen to perform its transportation and transformation functions properly. It is necessary to nourish the stomach yin, promote qi movement in the spleen, and prevent excessive greasiness from blocking qi movement. "Treatise on the Treatment of Syndromes · Treatment of the Spleen and Stomach" believes that "to treat stomach yin deficiency, use mild tonics with clearing properties". It is necessary to nourish the stomach yin, promote qi movement in the spleen, and nourish qi and yin.

[0040] The present invention uses wolfberries, jujubes, codonopsis pilosula, and rehmannia glutinosa to tonify the spleen and kidney, and citrus reticulata blanco and atractylodes macrocephala to soothe the liver and strengthen the spleen, which together serve as the sovereign herbs; scutellaria baicalensis and gardenia jasminoides to eliminate indigestion and clear heat, and fructus crataegi, medicated leaven, endothelium corneum gigeriae galli, and raphanus sativus to promote digestion and remove stagnation, relieve distension caused by food stagnation, and induce defecation to relieve constipation. Among them, fructus crataegi, medicated leaven, and endothelium corneum gigeriae galli promote digestion and remove stagnation, and raphanus sativus can not only relieve distension caused by food stagnation but also induce defecation to relieve constipation, which together serve as the ministerial herbs; polygonatum odoratum and fructus mume to nourish the stomach yin, and glehnia littoralis and ophiopogon japonicus to tonify the lung yin, serving as the assistant herbs; fingered citron and amomum villosum to promote qi movement in the spleen to prevent excessive greasiness from blocking qi movement, serving as the guiding herbs. The whole formula contains wolfberries, jujubes, codonopsis pilosula, rehmannia glutinosa, citrus reticulata blanco, atractylodes macrocephala, scutellaria baicalensis, gardenia jasminoides, fructus crataegi, medicated leaven, endothelium corneum gigeriae galli, raphanus sativus, polygonatum odoratum, fructus mume, glehnia littoralis, ophiopogon japonicus, fingered citron, and amomum villosum, which can tonify the spleen and kidney, soothe the liver and strengthen the spleen, eliminate indigestion and clear heat, promote digestion and remove stagnation, nourish the stomach yin, tonify the lung yin, and promote qi movement in the spleen. They are jointly formulated to treat children with anorexia due to spleen and kidney deficiency, achieving very good results. Detailed Implementation Modes

[0041] The following further elaborates the present invention in combination with the detailed implementation modes. It should be understood that these embodiments are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that after reading the content recorded in the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms also fall within the scope defined by the appended claims of this application.

[0042] Example 1:

[0043] Take 80 g of wolfberries, 100 g of Chinese dates, 70 g of codonopsis pilosula, 80 g of rehmannia glutinosa, 100 g of tangerine peel, 120 g of atractylodes macrocephala, 60 g of scutellaria baicalensis, 80 g of gardenia jasminoides, 120 g of stir-fried hawthorn, 100 g of medicated leaven, 80 g of chicken gizzard-membrane, 100 g of radish seed, 80 g of polygonatum odoratum, 70 g of smoked plum, 80 g of glehnia littoralis, 80 g of ophiopogon japonicus, 120 g of fingered citron, 80 g of amomum villosum. The preparation method includes the following steps:

[0044] (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush, and mix them evenly to obtain a traditional Chinese medicine mixture;

[0045] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, each time adding water in an amount 12 times the weight of the traditional Chinese medicine mixture, decocting for 2 hours each time, combine the three decoctions, filter to obtain a filtrate;

[0046] (3) Concentrate the filtrate obtained in step (2) into a clear paste with a relative density of 1.10, the concentration temperature is up to 80 °C, add ethanol to it until the volume percentage of ethanol is 70%, stir, let stand for 18 hours, filter, the obtained filtrate is concentrated under reduced pressure to recover ethanol, and concentrated to a relative density of 1.28 at 50 °C to obtain a concentrated solution, add sucrose to prepare an oral liquid.

[0047] Example 2: Take 60 g of wolfberries, 120 g of Chinese dates, 50 g of codonopsis pilosula, 100 g of rehmannia glutinosa, 80 g of tangerine peel, 140 g of atractylodes macrocephala, 40 g of scutellaria baicalensis, 100 g of gardenia jasminoides, 100 g of stir-fried hawthorn, 120 g of medicated leaven, 60 g of chicken gizzard-membrane, 120 g of radish seed, 60 g of polygonatum odoratum, 100 g of smoked plum, 60 g of glehnia littoralis, 100 g of ophiopogon japonicus, 100 g of fingered citron, 100 g of amomum villosum. The preparation method includes the following steps:

[0048] (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush, and mix them evenly to obtain a traditional Chinese medicine mixture;

[0049] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, each time adding water in an amount 8 times the weight of the traditional Chinese medicine mixture, decocting for 3 hours each time, combine the three decoctions, filter to obtain a filtrate;

[0050] (3) Concentrate the filtrate obtained in step (2) into a clear paste with a relative density of 1.05, the concentration temperature is up to 80 °C, add ethanol to it until the volume percentage of ethanol is 80%, stir, let stand for 12 hours, filter, the obtained filtrate is concentrated under reduced pressure to recover ethanol, and concentrated to a relative density of 1.30 at 50 °C to obtain a concentrated solution, add protein sugar to prepare an oral liquid.

[0051] Example 3: Take 100 g of wolfberries, 80 g of Chinese dates, 100 g of codonopsis pilosula, 60 g of prepared rehmannia root, 120 g of dried tangerine peel, 100 g of atractylodes macrocephala, 80 g of scutellaria baicalensis, 60 g of gardenia jasminoides, 140 g of stir-fried hawthorn fruit, 80 g of medicated leaven, 100 g of chicken gizzard-membrane, 80 g of radish seed, 100 g of polygonatum odoratum, 50 g of smoked plum, 100 g of glehnia littoralis, 60 g of ophiopogon japonicus, 140 g of fingered citron, and 60 g of amomum villosum. The preparation method includes the following steps:

[0052] (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush, and mix them evenly to obtain a traditional Chinese medicine mixture.

[0053] (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, with the amount of water added each time being 15 times the weight of the traditional Chinese medicine mixture, decoct for 1 hour each time, combine the three decoctions, filter, and obtain a filtrate.

[0054] (3) Concentrate the filtrate obtained in step (2) into a clear paste with a relative density of 1.15, with the concentration temperature reaching 80 °C. Add ethanol to it until the volume percentage of ethanol is 60%, stir, let it stand for 24 hours, filter, recover the ethanol under reduced pressure from the obtained filtrate, concentrate to a relative density of 1.25 at 50 °C to obtain a concentrated solution, add sucrose, and prepare it into an oral liquid.

[0055] Example 4: Pharmacodynamic study

[0056] 1. Effect on the intestinal propulsion movement of young mice: 30 ICR young mice were randomly divided into a blank group, a control group (original prescription Qizao Oral Liquid (Zhejiang Telisen Pharmaceutical Co., Ltd., national drug approval number B20020312), 10 ml / kg), and the group of Example 1 of the present invention (10 ml / kg), with 10 mice in each group, half male and half female. Administer the drug ig once a day for 3 consecutive days, with the administration volume of 20 mL / kg (diluted with deionized water), and the blank group ig an equal volume of deionized water. 40 minutes after the last administration (the mice were fasted for 5 h before administration), each group of mice was ig administered 2% Indian ink (prepared with 5% gum arabic solution). After 20 minutes, the mice were sacrificed by cervical dislocation, the abdomen was opened, and the intestinal segment from the whole stomach to the anus was gently taken out and separated, laid flat on a wax plate, the length from the pylorus to the ileocecal junction was measured as the total length of the small intestine, and the length from the pylorus to the advancing front of the ink was measured as the advancing length of the small intestine. Calculate the intestinal propulsion rate (intestinal propulsion rate = advancing length of the small intestine / total length of the small intestine). Compare the average intestinal propulsion rates of each drug administration group with the control group, and perform a statistical t-test, as shown in Table 1.

[0057] Table 1 Effect of the present invention on the intestinal propulsion movement of young mice

[0058] Group Intestinal propulsion rate / % Blank group 59.32±8.56 Control group <![CDATA[62.58±9.37 * > Example 1 group <![CDATA[83.49±9.15 **## >

[0059] Compared with the blank group * P < 0.05,** P < 0.01, compared with the control group # P < 0.05, ## P < 0.01.

[0060] As can be seen from Table 1, compared with the blank group, both the control group and Example 1 group could prolong the intestinal propulsion rate of young mice (P < 0.05; P < 0.01); compared with the control group, the Example 1 group of the present invention had a better effect on prolonging the intestinal propulsion rate of young mice. The results showed that the improved Qizao Oral Liquid had the effect of better promoting intestinal movement in young mice.

[0061] 2. Effect on gastric emptying in young mice: 30 ICR young mice were randomly divided into a blank group, a control group (original prescription Qizao Oral Liquid (Zhejiang Telisen Pharmaceutical Co., Ltd., National Medicine Approval No. B20020312), 10 ml / kg), and Example 1 group of the present invention (10 ml / kg), with 10 mice in each group, half male and half female. They were given drugs intragastrically once a day for 3 consecutive days, and the administration volume was 20 mL / kg (diluted with deionized water). The blank group was given an equal volume of deionized water intragastrically. According to the above method of drug administration, 4 h before the last drug administration and 40 min after the last drug administration, 0.1% phenol red solution (0.2 mL / mouse) was given intragastrically. After 20 min, the mice were sacrificed, the stomachs were removed, placed in a beaker, cut open along the greater curvature of the stomach, the gastric contents were rinsed with 5 mL of distilled water, the pH value was adjusted to 6.0 - 6.5, centrifuged at 3000 r / min for 10 min, and the supernatant was separated. The absorbance (A) value of phenol red in each sample was measured with an enzyme-linked immunosorbent assay (ELISA) at a wavelength of 420 nm. The A value of the solution prepared by adding 0.2 mL of 0.1% phenol red to 5 mL of distilled water was used as the phenol red absorption base number, and the residual rate of phenol red in the stomach of each group of animals was calculated (residual rate of phenol red in the stomach = A value of phenol red in the stomach / phenol red absorption base number). A statistical t-test was performed on the residual rate of phenol red in the stomach between each drug administration group and the control group, as shown in Table 2.

[0062] Table 2 Effect of the present invention on gastric emptying in young mice

[0063] Group Phenol red residue rate in stomach / % Blank group 26.582±5.751 Control group <![CDATA[21.845±3.217 ** > Example 1 group <![CDATA[14.932±3.178 **## >

[0064] Compared with the blank group * P < 0.05, ** P < 0.01, compared with the control group # P < 0.05, ## P < 0.01.

[0065] As can be seen from Table 1, compared with the blank group, both the control group and the Example 1 group could significantly reduce the residual rate of phenol red in the stomach of young mice (P < 0.01). Compared with the control group, the Example 1 group of the present invention had a better effect in reducing the residual rate of phenol red in the stomach of young mice. The results showed that the improved Qizao Oral Liquid had the effect of better reducing the residual rate of phenol red in the stomach of young mice, indicating that it could promote gastric emptying.

[0066] Example 5: Clinical Research

[0067] Case selection: 100 children with anorexia who visited the outpatient department of traditional Chinese pediatrics in Haiyan County Traditional Chinese Medicine Hospital from August 2021 to August 2023 all met the inclusion criteria. Among them, there were 52 males and 48 females, with an average age of (5.32 ± 2.69) years old. The shortest course of disease was 1 month, and the longest was 1 year.

[0068] Diagnosis and inclusion criteria: Western medicine diagnosis criteria: ① Long-term loss of appetite, not greedy for food, the amount of food intake significantly reduced compared with before, and the course of disease is more than 2 weeks, excluding other systemic diseases; ② Weight gain stagnation or reduction, with a history of bad eating habits or improper feeding; ③ Aged 2 years old or above and 12 years old or below. Traditional Chinese medicine syndrome differentiation criteria for spleen and kidney deficiency in anorexia: Loss of appetite, indigestion after eating, loose stools mixed with undigested food, less luster in complexion, emaciated body, fatigue, sparse and dull hair, pigeon chest and turtle back, retarded development, pale, plump tongue, or with tooth marks, red tongue, less tongue coating, weak pulse. Quantification criteria for the syndrome of spleen and kidney deficiency type: ① Loss of appetite, a 1 / 4 reduction in food intake compared with normal children of the same age (mild) is scored 3 points; a 1 / 2 reduction in food intake compared with normal children of the same age (moderate) is scored 6 points, and a 3 / 4 reduction in food intake compared with normal children of the same age (severe) is scored 9 points; ② Failure to gain weight, abdominal distension, nausea, vomiting, fatigue, sparse and dull hair, short stature, loose stools or constipation are each scored 2 points. Those with a score of ≥9 points were included.

[0069] Treatment method: Divided into two groups, the control group took the original prescription Qizao Oral Liquid (Zhejiang Telisen Pharmaceutical Co., Ltd., National Medicine Approval No. B20020312), 2 times / d, 1 branch (10 mL) / time, 14 days as a course of treatment, and took 2 courses of treatment. The administration group took the oral liquid prepared in Example 1 of the present invention (daily prescription amount: 8 g of wolfberry fruit, 10 g of Chinese date, 7 g of codonopsis pilosula, 8 g of prepared rehmannia root, 10 g of tangerine peel, 12 g of atractylodes macrocephala, 6 g of scutellaria baicalensis, 8 g of gardenia jasminoides, 12 g of stir-fried hawthorn fruit, 10 g of medicated leaven, 8 g of chicken gizzard-membrane, 10 g of radish seed, 8 g of polygonatum odoratum, 7 g of smoked plum, 8 g of glehnia littoralis, 8 g of ophiopogon japonicus, 12 g of fingered citron, 8 g of amomum villosum), 2 times / d, 14 days as a course of treatment, and took 2 courses of treatment. Quantitative scoring was carried out before treatment and at the end of each course of treatment. Other drugs for invigorating the spleen and stomach and drugs that may affect the observation of the curative effect of this trial were stopped during the medication period.

[0070] Criteria for evaluating the curative effect of anorexia: Recovery: disappearance of anorexia symptoms; Marked effect: significant reduction in anorexia symptoms, with the integral value reduced by ≥75%; Effective: reduction in anorexia symptoms, with the integral value reduced by ≥50% and <75%; Ineffective: no improvement in anorexia symptoms, with the integral value <50%. Curative effect index (%) = (integral before treatment - integral after treatment) / integral before treatment × 100%.

[0071] Results: The evaluation of the curative effect of anorexia is shown in Table 3.

[0072] Table 3 Evaluation of the curative effect of anorexia in two groups

[0073] Group Cured Markedly effective Effective Ineffective Effective rate (%) Drug administration group 15 20 11 4 92 Control group 12 16 14 8 84

[0074] Table 3 shows that after taking the original prescription Qizao Oral Liquid for 2 courses of treatment, 12 cases recovered, 16 cases had a marked effect, 14 cases were effective, and 8 cases were ineffective, with a total effective rate of 84.0%; after taking the Qizao Oral Liquid prepared by the method of Example 1 for 2 courses of treatment, 15 cases recovered, 20 cases had a marked effect, 11 cases were effective, and 4 cases were ineffective, with a total effective rate of 90.0%, indicating that the adjusted prescription has a better effect on children with anorexia of spleen and kidney deficiency type.

[0075] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Qizao Oral Liquid for treating infantile anorexia, characterized in that, It is prepared by extracting from the following raw medicinal materials in parts by weight: 6 - 10 parts of Chinese wolfberry, 8 - 12 parts of Chinese date, 5 - 10 parts of pilose asiabell root, 6 - 10 parts of prepared rehmannia root, 8 - 12 parts of dried tangerine peel, 10 - 14 parts of largehead atractylodes rhizome, 4 - 8 parts of scutellaria root, 6 - 10 parts of cape jasmine fruit, 10 - 14 parts of stir-fried hawthorn fruit, 8 - 12 parts of medicated leaven, 6 - 10 parts of dried chicken gizzard-membrane, 8 - 12 parts of radish seed, 6 - 10 parts of polygonatum odoratum, 5 - 10 parts of smoked plum, 6 - 10 parts of Glehnia littoralis root, 6 - 10 parts of dwarf lilyturf tuber, 10 - 14 parts of fingered citron, 6 - 10 parts of amomum villosum.

2. The Qizao Oral Liquid for treating infantile anorexia as described in claim 1, characterized in that, It is prepared by extracting from the following raw medicinal materials in parts by weight: 8 parts of Chinese wolfberry, 10 parts of Chinese date, 7 parts of pilose asiabell root, 8 parts of prepared rehmannia root, 10 parts of dried tangerine peel, 12 parts of largehead atractylodes rhizome, 6 parts of scutellaria root, 8 parts of cape jasmine fruit, 12 parts of stir-fried hawthorn fruit, 10 parts of medicated leaven, 8 parts of dried chicken gizzard-membrane, 10 parts of radish seed, 8 parts of polygonatum odoratum, 7 parts of smoked plum, 8 parts of Glehnia littoralis root, 8 parts of dwarf lilyturf tuber, 12 parts of fingered citron, 8 parts of amomum villosum.

3. The Qizao Oral Liquid for treating infantile anorexia according to claim 1, wherein, The preparation method comprises the following steps: (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush and mix evenly to obtain a traditional Chinese medicine mixture; (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, each time adding water in an amount 8 - 15 times the weight of the traditional Chinese medicine mixture, decoct for 1 - 3 hours each time, combine the three decoctions, filter to obtain a filtrate; (3) Concentrate the filtrate obtained in step (2) into a clear paste with a relative density of 1.05 - 1.15, the concentration temperature is up to 80 °C, add ethanol to it until the volume percentage of ethanol is 60% - 80%, stir, stand for 12 - 24 hours, filter, the obtained filtrate is concentrated under reduced pressure to recover ethanol, and concentrated to a relative density of 1.25 - 1.30 at 50 °C to obtain a concentrated solution, add a flavoring agent to prepare an oral liquid.

4. The Qizao Oral Liquid for treating infantile anorexia as described in claim 3, wherein The preparation method comprises the following steps: (1) Weigh various raw medicinal materials according to the above formula ratio, dry, crush and mix evenly to obtain a traditional Chinese medicine mixture; (2) Add water to the traditional Chinese medicine mixture obtained in step (1), decoct three times, each time adding water in an amount 12 times the weight of the traditional Chinese medicine mixture, decoct for 2 hours each time, combine the three decoctions, filter to obtain a filtrate; (3) Concentrate the filtrate obtained in step (2) into a clear paste with a relative density of 1.10, the concentration temperature is up to 80 °C, add ethanol to it until the volume percentage of ethanol is 70%, stir, stand for 18 hours, filter, the obtained filtrate is concentrated under reduced pressure to recover ethanol, and concentrated to a relative density of 1.28 at 50 °C to obtain a concentrated solution, add a flavoring agent to prepare an oral liquid.

5. Use of the Qi-Zao oral liquid for treating infantile anorexia as described in claim 1 in the preparation of drugs for treating infantile anorexia.

6. Use of the Qizao Oral Liquid for treating infantile anorexia as claimed in claim 1 in the preparation of a medicament for treating infantile anorexia, characterized in that, The infantile anorexia is of the spleen-kidney deficiency syndrome type.