A traditional Chinese medicine composition for treating chronic mountain sickness and a preparation method thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating chronic mountain sickness and a preparation method thereof, and comprises the following components in the following amounts by weight: Fuzi 3-6g, Xiesheng 0.5-1.5g, Guizhi 1-2-4g, Zexie 2-4g, Kuaxingren 2-4g, Chuanxinlian 2-4g, Ziyuan 2-4g, Bingpian 0.2-0.4g, Honghua 2-4g, Kuanfenghua 2-4g, Huangqi 3-6g, Xuanfuhua 1-2g, Yimucao 2-4g, Zhigancao 1-2g, Baihe 1-3g, Mosha 0.2-0.7g, Renshen 0.5-1.5g, Gegen 2-4g, Danshen 2-4g, Wuyizi 0.5-1.5g, Jiezi 1-2g, Zekai 2-4g, Tuzhongteng 2-4g, Ganjiang 1-3g and Tinglizi 2-4g. The application not only has a remarkable improvement effect on symptoms such as coldness, qi stagnation and blood vessel obstruction caused by the mountain sickness, but also has the effects of clearing heat and resolving toxins, resolving phlegm and relieving cough, and is helpful for relieving symptoms such as cough and excessive phlegm caused by the mountain sickness.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating chronic mountain sickness and a preparation method thereof. Background Art

[0002] Monges disease (MD), also known as chronic mountain sickness, is a chronic hypoxic disorder that can occur in people who have lived or migrated to altitudes above 2,500 meters. Its main clinical manifestations include severe polycythemia, hypoxemia, pulmonary vascular remodeling, and pulmonary hypertension (HPH). Globally, over 100 million people live in such high-altitude environments, and approximately 5-10% of them are at risk of developing MD.

[0003] Pulmonary vascular remodeling is a key pathological process in MD, and this remodeling is difficult to reverse. Therefore, MD poses a serious threat to the safety of people working in high altitude settings for extended periods. Currently, there is a lack of effective treatments for MD, so exploring Traditional Chinese Medicine (TCM) approaches to prevent and treat MD has important strategic and clinical implications.

[0004] Recent studies have demonstrated that heterozygous mutations in bone transformation protein receptor 2 (BMPR2) play a key role in pulmonary vascular remodeling in familial HPH. Functional inactivation of BMPR2 can lead to endothelial dysfunction and an imbalance between cell proliferation and apoptosis. Furthermore, BMPR2-associated cytokines, such as epidermal growth factor (EGF), hypoxia-inducible factor 1 (HIF1), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), activate platelets and vascular endothelial cells through various signaling pathways, further leading to arteriolar thrombosis, luminal stenosis, or small vessel occlusion, ultimately promoting pulmonary vascular remodeling.

[0005] Based on these research findings, restoring BMPR2 function may be an effective strategy for treating HPH and MD. Traditional Chinese medicine, a treasure trove of traditional Chinese medicine, possesses a unique theoretical framework and rich practical experience. Therefore, exploring TCM approaches for the prevention and treatment of MD may reveal new therapeutic options for MD by discovering drugs that can restore BMPR2 function or regulate related cytokines.

[0006] In summary, developing a kind of traditional Chinese medicine composition and its preparation method which can effectively treat MD has important significance for improving the health level of the crowd in highland area of China, protecting the life safety of the officers and soldiers in highland, and promoting the modernization and internationalization of traditional Chinese medicine. Therefore, the application provides a kind of traditional Chinese medicine composition and its preparation method for treating chronic high altitude disease. SUMMARY

[0007] The application provides a kind of traditional Chinese medicine composition and its preparation method for treating chronic high altitude disease, which not only has a significant improvement effect on the symptoms such as coldness, qi stagnation and blood vessel obstruction caused by high altitude disease, but also has the effects of clearing heat and resolving toxicity, reducing phlegm and relieving cough, which helps to relieve the symptoms such as cough and excessive phlegm caused by high altitude disease.

[0008] In order to achieve the above-mentioned purpose, the technical scheme of the application is as follows: a kind of traditional Chinese medicine composition for treating chronic high altitude disease, which is made of the following raw materials by weight: Fuzi 3-6g, Xixin 0.5-1.5g, Guizhi 1-4g, Zexie 2-4g, Kuaxingren 2-4g, Chuanxinlian 2-4g, Ziyuan 2-4g, Bingpian 0.2-0.4g, Honghua 2-4g, Kuanfenghua 2-4g, Huangqi 3-6g, Xuanfuhua 1-2g, Yimucao 2-4g, Zhigancao 1-2g, Baihe 1-3g, Mushixiang 0.2-0.7g, Renshen 0.5-1.5g, Gegen 2-4g, Danshen 2-4g, Wuyizi 0.5-1.5g, Jiezi 1-2g, Zekai 2-4g, Tuzhongteng 2-4g, Ganjiang 1-3g and Tinglizi 2-4g.

[0009] Further, the following raw materials are used by weight: Fuzi 3g, Xixin 0.5g, Guizhi 1g, Zexie 2g, Kuaxingren 2g, Chuanxinlian 2g, Ziyuan 2g, Bingpian 0.2g, Honghua 2g, Kuanfenghua 2g, Huangqi 3g, Xuanfuhua 1g, Yimucao 2g, Zhigancao 1g, Baihe 1g, Mushixiang 0.2g, Renshen 0.5g, Gegen 2g, Danshen 2g, Wuyizi 0.5g, Jiezi 1g, Zekai 2g, Tuzhongteng 2g, Ganjiang 1g and Tinglizi 2g.

[0010] Further, the following raw materials are used by weight: Fuzi 4.5g, Xixin 1g, Guizhi 2g, Zexie 3g, Kuaxingren 3g, Chuanxinlian 3g, Ziyuan 3g, Bingpian 0.3g, Honghua 3g, Kuanfenghua 3g, Huangqi 4.5g, Xuanfuhua 1.5g, Yimucao 3g, Zhigancao 1.5g, Baihe 2g, Mushixiang 0.5g, Renshen 1g, Gegen 3g, Danshen 3g, Wuyizi 1g, Jiezi 1.5g, Zekai 3g, Tuzhongteng 3g, Ganjiang 2g and Tinglizi 3g.

[0011] Further, it is prepared from the following raw materials by weight: 6g of aconite root, 1.5g of asarum, 3g of cinnamon twig, 4g of oriental rhizome, 4g of bitter almond, 4g of andrographis paniculata, 4g of aster, 0.4g of borneol, 4g of safflower, 4g of coltsfoot flower, 6g of astragalus, 2g of inula flower, 4g of motherwort, 2g of roasted liquorice, 3g of lily, 0.7g of musk, 1.5g of ginseng, 4g of kudzu root, 4g of salvia miltiorrhiza, 1.5g of schisandra chinensis, 2g of mustard seed, 4g of zedoaria, 4g of smilax glabra, 3g of dried ginger and 4g of scutellaria baicalensis.

[0012] A method for preparing a traditional Chinese medicine composition for treating chronic mountain sickness, comprising the following specific steps:

[0013] Step 1: Select Chinese medicinal materials according to the composition and prepare them.

[0014] Step 2: Put the prepared Chinese medicinal materials into the grinder and grind them into fine powder.

[0015] Step 3: Mix the powdered medicinal materials evenly according to the composition ratio.

[0016] Step 4: Pour the mixed Chinese medicine powder into the granulator, add a binder and make granules.

[0017] Step 5: Place the prepared Chinese medicine granules into a drying oven for drying.

[0018] Step 6: Pack the dried Chinese medicine granules.

[0019] Furthermore, the processing in step one includes but is not limited to frying, roasting and steaming.

[0020] Furthermore, the adhesive in step 4 includes but is not limited to one or more of honey, syrup and plant gum.

[0021] Furthermore, before packaging in step six, the dried Chinese medicine granules need to be screened to remove unqualified granules.

[0022] The efficacy of the Chinese herbal medicines in the above formula for treating chronic mountain sickness is as follows:

[0023] Aconite: It has the effects of warming the yang, dispersing cold, and promoting blood circulation. It has a significant effect on improving symptoms such as cold stagnation, qi stagnation, and blood circulation obstruction caused by chronic mountain sickness.

[0024] Asarum: It has the effects of warming the lungs and dispersing cold, opening the orifices and relieving pain. It can be used to treat symptoms such as cough and asthma in altitude sickness.

[0025] Cinnamon twig: It has the effects of warming the meridians and dispersing cold, promoting yang and transforming qi, and is effective for the cold symptoms of chronic mountain sickness.

[0026] Alisma: It has the effects of diuresis, dehumidification and heat dissipation, and helps relieve symptoms such as edema and oliguria in altitude sickness.

[0027] Bitter almonds: can relieve cough and asthma and moisten the intestines and promote bowel movements. They can improve cough, asthma and intestinal discomfort caused by altitude sickness.

[0028] Andrographis paniculata: It has the effects of clearing away heat and detoxifying, cooling blood and reducing swelling, and can alleviate the symptoms of heat and toxicity in altitude sickness.

[0029] Aster: It has the effects of moistening the lungs, relieving coughs, resolving phlegm and relieving asthma. It has a therapeutic effect on symptoms such as cough and phlegm in altitude sickness.

[0030] Camphor: It can invigorate the mind, clear away heat and relieve pain, and can alleviate symptoms such as coma and headache caused by altitude sickness.

[0031] Safflower: It has the effects of promoting blood circulation, relieving menstruation, dispersing blood stasis and relieving pain, and can improve the blood stasis symptoms of altitude sickness.

[0032] Coltsfoot flower: It can moisten the lungs, relieve coughs, resolve phlegm and relieve asthma, and has a therapeutic effect on symptoms such as cough and asthma in altitude sickness.

[0033] Astragalus: It has the effects of replenishing qi and strengthening the exterior, as well as promoting diuresis and reducing swelling. It can improve symptoms such as qi deficiency and edema in altitude sickness.

[0034] Inula flower: It can reduce Qi, resolve phlegm, relieve cough and asthma, and has therapeutic effects on symptoms such as cough and asthma in altitude sickness.

[0035] Motherwort: It has the effects of promoting blood circulation, regulating menstruation, and promoting diuresis and reducing swelling. It can improve symptoms such as irregular menstruation and edema in altitude sickness.

[0036] Roasted licorice root: It can nourish the spleen and stomach and harmonize the medicinal properties. It can relieve the symptoms of spleen and stomach disharmony in altitude sickness.

[0037] Lily: It has the effects of nourishing yin and moistening the lungs, clearing the heart and calming the mind, and can improve symptoms such as yin deficiency and palpitations in altitude sickness.

[0038] Musk: It can open the orifices, wake up the mind, activate blood circulation and disperse stagnation, and can relieve symptoms such as coma and blood stasis in altitude sickness.

[0039] Ginseng: It has the effect of replenishing vital energy and strengthening the spleen and lungs, and has a significant effect on improving the symptoms of qi deficiency and lung deficiency in altitude sickness.

[0040] Pueraria root: It can relieve muscles, reduce fever, promote salivation and quench thirst, and can alleviate symptoms such as fever and thirst in altitude sickness.

[0041] Salvia miltiorrhiza: It has the effects of promoting blood circulation, removing blood stasis, promoting menstruation and relieving pain. It can improve the symptoms of blood stasis and dysmenorrhea in altitude sickness.

[0042] Schisandra chinensis: It can astringe, strengthen qi and promote the production of body fluids, and can relieve symptoms such as qi deficiency and excessive sweating in altitude sickness.

[0043] Mustard seeds: can warm the lungs, eliminate phlegm, and promote qi circulation and disperse stagnation. They have therapeutic effects on symptoms such as cough and phlegm in altitude sickness.

[0044] Zeqi: It has the effects of promoting water circulation, reducing swelling, resolving phlegm and relieving cough. It can improve the symptoms of edema and cough in altitude sickness.

[0045] Wild Smilax glabra: It can detoxify, remove dampness and open up the joints, and can relieve the symptoms of dampness and joint discomfort in altitude sickness.

[0046] Dried ginger: It has the effects of warming the middle and dispersing cold, restoring yang and unblocking the meridians, and is effective for the cold symptoms of chronic mountain sickness.

[0047] Trichosanthes kirilowii: It can clear the lungs, lower qi, eliminate phlegm and relieve asthma, and has a therapeutic effect on symptoms such as cough and asthma in altitude sickness.

[0048] In summary, this Chinese medicine composition, by integrating the efficacy of various medicinal materials, can comprehensively regulate the body, improve the various symptoms caused by chronic mountain sickness, and improve the quality of life of patients.

[0049] The following beneficial effects are achieved by adopting the above scheme:

[0050] 1. The Chinese medicine composition of this invention is composed of carefully selected Chinese medicinal materials, which work synergistically to effectively treat chronic mountain sickness. Herbs such as aconite root, asarum root, and cassia twig in the formula warm the yang and dispel cold, promoting blood circulation and activating collaterals, significantly improving symptoms of mountain sickness, such as cold stagnation, qi stagnation, and blood circulation blockage. Furthermore, herbs such as oriental rhizome, bitter almond, and andrographis paniculata clear heat and detoxify, resolve phlegm, and relieve cough, helping to alleviate symptoms such as cough and phlegm caused by mountain sickness.

[0051] 2. The preparation method of the Chinese medicine composition of the present invention is simple and easy to understand, easy to operate, and conducive to industrial production. Through the steps of grinding, mixing, granulation and drying, the Chinese medicine composition granules can be obtained, which are convenient for patients to take.

[0052] 3. The Chinese herbal composition of the present invention is highly effective in treating chronic mountain sickness, effectively alleviating symptoms and improving patients' quality of life. Furthermore, it has the advantages of minimal side effects and high safety, making it suitable for long-term use.

[0053] 4. The Chinese medicine combination is suitable for patients with chronic mountain sickness with different conditions and constitutions. The dosage and ratio of the medicinal materials can be adjusted according to the patient's specific situation to achieve personalized treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] Figure 1 This is a prediction diagram of the effect of the Chinese medicine composition monomer of the embodiment of the present invention on BMPR2-smads related signals.

[0055] Figure 2 This is a cross-sectional view of a mixing device according to Example 6 of the present invention. DETAILED DESCRIPTION

[0056] The following describes embodiments of the present invention in detail. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended only to explain the present invention and are not to be construed as limiting the present invention.

[0057] In the description of the present invention, it should be understood that the terms "longitudinal", "transverse", "vertical", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0058] In the description of the present invention, unless otherwise specified and limited, it should be noted that the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a mechanical connection or an electrical connection, or it can be the internal communication between two components. It can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to the specific circumstances.

[0059] The following is further described in detail through specific implementation methods:

[0060] The figure marks in the drawings of the specification include: housing 1, storage box 2, opening 201, solenoid valve 202, cam 3, push rod 4, spring 401, mounting plate 5, roller 501, push plate 6, strain gauge 7, mixing box 8, second motor 9, rotating shaft 901, stirring rod 902.

[0061] Example 1, basically as in the attached Figure 1The invention discloses a traditional Chinese medicine composition for treating chronic mountain sickness, which is prepared from the following raw materials by weight: 3-6g of aconite root, 0.5-1.5g of asarum, 1-4g of cinnamon twig, 2-4g of oriental rhizome, 2-4g of bitter almond, 2-4g of andrographis paniculata, 2-4g of aster root, 0.2-0.4g of borneol, 2-4g of safflower, 2-4g of coltsfoot flower, 3-6g of astragalus, 1-2g of inula flower, 2-4g of motherwort, 1-2g of pre-roasted liquorice, 1-3g of lily, 0.2-0.7g of musk, 0.5-1.5g of ginseng, 2-4g of kudzu root, 2-4g of salvia miltiorrhiza, 0.5-1.5g of schisandra chinensis, 1-2g of mustard seed, 2-4g of zedoaria, 2-4g of smilax glabra, 1-3g of dried ginger and 2-4g of scutellaria baicalensis.

[0062] Example 2 is different from the above example in that it is prepared from the following raw materials by weight: 3g of aconite root, 0.5g of asarum, 1g of cinnamon twig, 2g of oriental rhizome, 2g of bitter almond, 2g of andrographis paniculata, 2g of aster root, 0.2g of borneol, 2g of safflower, 2g of coltsfoot flower, 3g of astragalus, 1g of inula flower, 2g of motherwort, 1g of pre-roasted liquorice root, 1g of lily, 0.2g of musk, 0.5g of ginseng, 2g of kudzu root, 2g of salvia miltiorrhiza, 0.5g of schisandra chinensis, 1g of mustard seed, 2g of zedoaria, 2g of smilax glabra, 1g of dried ginger and 2g of scutellaria baicalensis.

[0063] Example 3 is different from the above example in that it is prepared from the following raw materials by weight: 4.5g of aconite root, 1g of asarum, 2g of cinnamon twig, 3g of oriental rhizome, 3g of bitter almond, 3g of andrographis paniculata, 3g of aster, 0.3g of borneol, 3g of safflower, 3g of coltsfoot flower, 4.5g of astragalus, 1.5g of inula flower, 3g of motherwort, 1.5g of roasted liquorice root, 2g of lily, 0.5g of musk, 1g of ginseng, 3g of kudzu root, 3g of salvia miltiorrhiza, 1g of schisandra chinensis, 1.5g of mustard seed, 3g of zedoaria, 3g of smilax glabra, 2g of dried ginger and 3g of scutellaria baicalensis.

[0064] Example 4 is different from the above example in that it is prepared from the following raw materials by weight: 6g of aconite root, 1.5g of asarum, 3g of cinnamon twig, 4g of oriental rhizome, 4g of bitter almond, 4g of andrographis paniculata, 4g of aster, 0.4g of borneol, 4g of safflower, 4g of coltsfoot flower, 6g of astragalus, 2g of inula flower, 4g of motherwort, 2g of pre-roasted liquorice root, 3g of lily, 0.7g of musk, 1.5g of ginseng, 4g of kudzu root, 4g of salvia miltiorrhiza, 1.5g of schisandra chinensis, 2g of mustard seed, 4g of zedoaria, 4g of smilax glabra, 3g of dried ginger and 4g of scutellaria baicalensis.

[0065] Example 5 is different from the above examples in that the preparation method of the Chinese medicine composition for treating chronic mountain sickness is as follows:

[0066] Step 1: Select Chinese medicinal materials according to the composition and process them; processing includes but is not limited to frying, roasting and steaming.

[0067] Step 2: Put the prepared Chinese medicinal materials into the grinder and grind them into fine powder.

[0068] Step 3: Mix the powdered medicinal materials evenly according to the composition ratio.

[0069] Step 4: Pour the mixed Chinese medicine powder into the granulator, add a binder, and make granules. The binder includes but is not limited to one or more of honey, syrup and plant gum.

[0070] Step 5: Place the prepared Chinese medicine granules into a drying oven for drying.

[0071] Step 6: Packaging the dried Chinese medicine granules. Before packaging, the dried Chinese medicine granules need to be screened to remove unqualified granules and pack qualified granules.

[0072] The weight of the raw materials in the embodiment is selected according to any one of Examples 1-4.

[0073] The specific implementation process is as follows:

[0074] Step 1: Based on the formulation requirements of the traditional Chinese medicine composition for treating chronic mountain sickness, select Chinese medicinal herbs such as aconite root, asarum root, cinnamon twig, oriental water chestnut, and bitter almond. These herbs are then processed, such as stir-frying aconite root to enhance its warming and cold-dispersing properties and roasting asarum root to improve its efficacy.

[0075] Step 2: Place the prepared Chinese medicinal materials into the grinder and use the high-speed rotating grinding blades to grind them into fine powder. Ensure that the particle size of the medicinal materials meets the granulation requirements to ensure the smooth progress of the subsequent granulation process.

[0076] Step 3: Mix the ground medicinal materials according to the formula ratio. Stirring or vibration can be used to ensure that the ingredients are fully mixed and evenly distributed. In this embodiment, the weight composition of Example 3 is used.

[0077] Step 4: Pour the mixed herbal powder into a granulator and add an appropriate amount of binder. The binder can be one or more of honey, syrup, or plant gum to ensure the granules' formability and stability. The granulator then uses pressure and shear to form the powder into granules.

[0078] Step 5: Place the prepared Chinese medicine granules in a drying oven for drying. Control the appropriate temperature and time to avoid loss and destruction of the medicinal ingredients and ensure the dryness and stability of the granules.

[0079] Step 6: Before packaging, the dried TCM granules are screened. Oversized and undersized particles are removed through the screen to ensure that the granules meet standard particle size and quality. Qualified granules are then packaged in well-sealed bags or glass bottles to ensure moisture resistance, airtightness, and storage stability.

[0080] Select herbs such as aconite root, asarum root, cinnamon twig, oriental rhizome, bitter almond, andrographis paniculata, aster root, borneol, safflower, coltsfoot flower, astragalus root, inula flower, motherwort, roasted licorice root, lily bulb, musk, ginseng, kudzu root, salvia miltiorrhiza, schisandra chinensis, mustard seed, lacquer, smilax glabra, dried ginger, and scutellaria baicalensis seed, and perform other processing methods such as stir-frying and roasting. Grind the processed herbs into a fine powder to ensure that the particle size meets the granulation requirements.

[0081] Mix the powdered herbs in the following proportions: 4.5g of Aconite, 1g of Asarum, 2g of Cinnamon Twig, 3g of Alisma, 3g of Apricot, 3g of Andrographis, 3g of Aster, 0.3g of Borneolum, 3g of Carthamus, 3g of Coltsfoot, 4.5g of Astragalus, 1.5g of Inula, 3g of Leonurus, 1.5g of Radix Glycyrrhizae Preparata, 2g of Lilium, 0.5g of Musk, 1g of Ginseng, 3g of Pueraria, 3g of Salvia, 1g of Schisandra, 1.5g of Sinapis, 3g of Rhizoma Zingiberis, 3g of Rhizoma Smilacis Glabrae, 2g of Dry Zingiber Officinale, and 3g of Leonurus. Ensure that all ingredients are thoroughly mixed. Add an appropriate amount of honey as a binder and form the mixed powder into granules. Place the resulting granules in a drying oven at 60°C for 2 hours for drying.

[0082] The dried Chinese medicine granules are screened to remove unqualified granules. The qualified Chinese medicine granules are packed into well-sealed packaging bags and stored in a cool and dry place.

[0083] Clinical trials have shown good technical results. Some clinical data are as follows:

[0084] 1. Case Selection: Eighty inpatients and outpatients with chronic mountain sickness were randomly divided into an observation group and a control group, 40 cases in each group, according to computer-generated random numbers. There were no statistically significant differences between the two groups in terms of gender, age, body mass index (BMI), disease severity, comorbidities, lifestyle, dietary habits, disease course, heart rate, systolic blood pressure, diastolic blood pressure, and cardiac function level (all P > 0.05; as shown in Table 1 ). This balance ensured comparability between the two groups and provided a reliable basis for subsequent observation and evaluation of therapeutic efficacy.

[0085] Table 1 Comparison of patient data between the two groups

[0086]

[0087] 2. Treatment methods:

[0088] The treatment of both groups of patients was carried out in accordance with the "Guidelines for the Treatment of Chronic Mountain Sickness", with the treatment of heart damage as the main goal.

[0089] The control group used conventional Western medicine treatment, and the specific drug names and dosages were selected and adjusted according to the guidelines and the patient's condition.

[0090] The observation group took the traditional Chinese medicine composition for treating chronic mountain sickness on the basis of conventional treatment, once a day, with the dosage adjusted appropriately according to the patient's weight and condition.

[0091] The treatment course was 2 months, and during the treatment period, appropriate treatment could be given to other concomitant diseases according to the patient's specific condition, such as anti-infection treatment if combined with infection. However, in order to ensure the accuracy and reliability of the study, the patients were prohibited from using other drugs or therapies related to the treatment of chronic mountain sickness during the treatment period.

[0092] 3. Comparison of efficacy table:

[0093]

[0094] From the above comparison table, it can be seen that the observation group had a higher proportion of patients with significant improvement and improved detection indicators than the control group, while the proportion of ineffective patients was lower than the control group. In addition, no adverse reactions occurred in the observation group, while 7.5% of patients in the control group experienced adverse reactions.

[0095] 4. Conclusion:

[0096] Based on the results of this clinical experiment, the following conclusions can be drawn:

[0097] In terms of treating chronic mountain sickness, the observation group using traditional Chinese medicine composition had significantly better efficacy than the control group, with a higher proportion of patients with significant improvement and improved detection indicators, and a lower proportion of ineffective patients.

[0098] Among the patients treated for chronic mountain sickness, the symptom remission rate reached 95%. Most patients experienced significant relief of symptoms such as headache, fatigue, and difficulty breathing after continuous use of the traditional Chinese medicine composition for a period of time.

[0099] After long-term observation, it was found that the traditional Chinese medicine composition had good drug efficacy persistence. Within a month after stopping the drug, most patients did not experience significant rebound in symptoms. During the entire clinical experiment, no significant adverse reactions or side effects were found. Patients had good tolerance to the traditional Chinese medicine composition, and it had high safety.

[0100] In summary, the use of traditional Chinese medicine composition for treating chronic mountain sickness has good efficacy and safety, and is worthy of further research and promotion.

[0101] Example 6, which differs from the above examples in that, as shown in Fig. 6, the device for mixing in step three comprises a shell 1, a plurality of storage boxes 2 are fixedly connected in the shell 1, a plurality of first motors are uniformly installed above the storage boxes 2, the first motors are fixedly connected to the inner side wall of the shell 1, cams 3 are fixedly connected to the output shafts of the first motors, and the diameters of the cams 3 are all different. Figure 2

[0102] The bottom wall of the storage box 2 is provided with a round hole, a push rod 4 is inserted into the round hole, an installation plate 5 is fixedly connected to the top end of the push rod 4, a roller 501 is installed on the end of the installation plate 5 away from the push rod 4, a spring 401 is sleeved on the push rod 4 below the installation plate 5, one end of the spring 401 is fixedly connected to the installation plate 5, the other end of the spring 401 is fixedly connected to the top wall of the storage box 2, a push plate 6 is fixedly connected to the end of the push rod 4 extending into the storage box 2, the push plate 6 is in sliding fit with the inner side wall of the storage box 2, and a strain gauge 7 is installed on the inner side wall of the storage box 2.

[0103] The bottom of the storage box 2 is provided with an opening 201, the bottom of the shell 1 below the storage box 2 is fixedly connected with a mixing box 8, the mixing box 8 is in communication with the opening 201, a second motor 9 is fixedly connected to the inner top wall of the mixing box 8, a rotating shaft 901 is coaxially fixedly connected to the output shaft of the second motor 9, a plurality of stirring rods 902 are fixedly connected to the rotating shaft 901, and the bottom of the mixing box 8 is provided with a discharge port and a cover body for closing the discharge port.

[0104] An electromagnetic valve 202 is installed at the opening 201, the electromagnetic valve 202 is signal connected with a controller, and the controller is signal connected with the strain gauge 7, the first motor and the second motor 9.

[0105] The specific implementation process is as follows: before use, the required amount of different medicinal materials in the corresponding formula is placed in different storage boxes 2 after being ground into powder. The device is suitable for mixing medicinal materials of different formulas, and only the positions and amounts of different medicinal materials in the storage boxes 2 need to be adjusted according to the formula requirements. This flexibility enables the device to cope with a variety of mixing tasks.

[0106] When the medicinal materials need to be mixed, the first motor is started through the controller, the first motor drives the cam 3, when the cam 3 rotates, when the protruding part of the cam 3 abuts against the roller 501, it moves downward, and when the protruding part of the cam 3 is separated from the roller 501, it moves upward. When the movement is downward, the roller 501 drives the push rod 4, and the push rod 4 moves up and down under the action of the spring 401. Due to the different diameters of the cams 3, the movement stroke and speed of the push rod 4 can be easily changed by adjusting the size and position of the cam 3, so as to adjust the dispensing amount and mixing speed of the medicinal powder.

[0107] ​When the protruding part of the cam 3 rotates downward, it pushes the spring 401 downward, and the push rod 4 moves downward, driving the push plate 6. When the push plate 6 slides on the inner wall of the storage box 2, it passes through the strain gauge 7. The strain gauge 7 transmits the detection data to the controller. After receiving the signal from the strain gauge 7, the controller starts to open the solenoid valve 202. When the push plate 6 slides inside the storage box 2, the powder in the storage box 2 is pushed out to the opening 201.

[0108] When the protruding portion of the cam 3 rotates upward, it drives the spring 401 upward, causing the push rod 4 to move upward, thereby moving the push plate 6 upward. When the push plate 6 slides along the inner wall of the storage box 2, it passes the strain gauge 7 again. The strain gauge 7 transmits the detection data to the controller, and after receiving the signal from the strain gauge 7 again, the controller starts to close the solenoid valve 202.

[0109] When the medicine powder falls into the mixing box 8 in proportion, the controller starts the second motor 9 , the second motor 9 drives the rotating shaft 901 , the rotating shaft 901 drives the stirring rod 902 , and the stirring rod 902 stirs and mixes the medicine powder in the mixing box 8 .

[0110] The device achieves automated and precise medicinal material delivery through the combination of a motor, cam 3, and strain gauge 7. This reduces manual operation errors and improves mixing accuracy. The coordination of the second motor 9 and stirring rod 902 ensures that the powdered medicine in the mixing box 8 is thoroughly stirred, ensuring uniform mixing of the different medicinal materials and improving the stability and consistency of the medicinal efficacy.

[0111] In summary, this mixing device and its operating method have the advantages of automation, precision, uniform mixing, space saving, adjustability, flexibility and safety, and are suitable for medicinal material mixing tasks in medical institutions and pharmaceutical factories.

[0112] The above is only an embodiment of the present invention, and common knowledge such as the specific structure and / or characteristics of the scheme is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the structure of the present invention, several variations and improvements can be made, which should also be regarded as the scope of protection of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A Chinese medicine composition for treating chronic mountain sickness, characterized in that: The invention is prepared from the following raw materials by weight: 3-6g of aconite root, 0.5-1.5g of asarum, 1-4g of cinnamon twig, 2-4g of oriental rhizome, 2-4g of bitter almond, 2-4g of andrographis paniculata, 2-4g of aster root, 0.2-0.4g of borneol, 2-4g of safflower, 2-4g of coltsfoot flower, 3-6g of astragalus, 1-2g of inula flower, 2-4g of motherwort, 1-2g of roasted liquorice root, 1-3g of lily, 0.2-0.7g of musk, 0.5-1.5g of ginseng, 2-4g of kudzu root, 2-4g of salvia miltiorrhiza, 0.5-1.5g of schisandra chinensis, 1-2g of mustard seed, 2-4g of zedoaria, 2-4g of smilax glabra, 1-3g of dried ginger and 2-4g of scutellaria baicalensis.

2. The Chinese medicine composition for treating chronic mountain sickness according to claim 1, characterized in that: The medicine is prepared from the following raw materials by weight: 3g of aconite root, 0.5g of asarum, 1g of cinnamon twig, 2g of oriental rhizome, 2g of bitter almond, 2g of andrographis paniculata, 2g of aster root, 0.2g of borneol, 2g of safflower, 2g of coltsfoot flower, 3g of astragalus, 1g of inula flower, 2g of motherwort, 1g of pre-roasted liquorice root, 1g of lily, 0.2g of musk, 0.5g of ginseng, 2g of kudzu root, 2g of salvia miltiorrhiza, 0.5g of schisandra chinensis, 1g of mustard seed, 2g of zedoaria, 2g of smilax glabra, 1g of dried ginger and 2g of scutellaria baicalensis.

3. The Chinese medicine composition for treating chronic mountain sickness according to claim 1, characterized in that: The medicine is prepared from the following raw materials by weight: 4.5g of aconite root, 1g of asarum, 2g of cinnamon twig, 3g of oriental rhizome, 3g of bitter almond, 3g of andrographis paniculata, 3g of aster root, 0.3g of borneol, 3g of safflower, 3g of coltsfoot flower, 4.5g of astragalus, 1.5g of inula flower, 3g of motherwort, 1.5g of roasted liquorice root, 2g of lily, 0.5g of musk, 1g of ginseng, 3g of kudzu root, 3g of salvia miltiorrhiza, 1g of schisandra chinensis, 1.5g of mustard seed, 3g of zedoaria, 3g of smilax glabra, 2g of dried ginger and 3g of scutellaria baicalensis seed.

4. The Chinese medicine composition for treating chronic mountain sickness according to claim 1, characterized in that: The medicine is prepared from the following raw materials by weight: 6g of aconite root, 1.5g of asarum, 3g of cinnamon twig, 4g of oriental rhizome, 4g of bitter almond, 4g of andrographis paniculata, 4g of aster root, 0.4g of borneol, 4g of safflower, 4g of coltsfoot flower, 6g of astragalus, 2g of inula flower, 4g of motherwort, 2g of pre-roasted liquorice root, 3g of lily, 0.7g of musk, 1.5g of ginseng, 4g of kudzu root, 4g of salvia miltiorrhiza, 1.5g of schisandra chinensis, 2g of mustard seed, 4g of zedoaria, 4g of smilax glabra, 3g of dried ginger and 4g of scutellaria baicalensis.

5. A method for preparing a traditional Chinese medicine composition for treating chronic mountain sickness, characterized in that: The Chinese medicine composition for treating chronic mountain sickness according to any one of claims 1 to 4 is prepared in the following steps: Step 1: selecting Chinese medicinal materials according to the composition and processing them; Step 2: Put the prepared Chinese medicinal materials into the grinder and grind them into fine powder; Step 3: Mix the ground medicinal materials evenly according to the composition ratio; Step 4: Pour the mixed Chinese medicine powder into the granulator, add a binder, and make granules; Step 5: Place the prepared Chinese medicine granules into a drying oven for drying; Step 6: Pack the dried Chinese medicine granules.

6. The method for preparing the Chinese medicine composition for treating chronic mountain sickness according to claim 5, characterized in that: The processing in step one includes but is not limited to frying, roasting and steaming.

7. The method for preparing the Chinese medicine composition for treating chronic mountain sickness according to claim 5, characterized in that: The adhesive in step 4 includes but is not limited to one or more of honey, syrup and plant glue.

8. The method for preparing the Chinese medicine composition for treating chronic mountain sickness according to claim 5, characterized in that: Before packaging in step six, the dried Chinese medicine granules need to be screened to remove unqualified granules.

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