A traditional Chinese medicine composition for improving male sexual function, a traditional Chinese medicine preparation and a preparation method thereof

Abstract

The application discloses a traditional Chinese medicine composition for improving male sexual function, a traditional Chinese medicine preparation and a preparation method thereof, and comprises the following components in parts by weight: semen cuscutae 10-20 parts, semen foeniculi 10-20 parts, schisandra chinensis 3-12 parts, raspberry 10-20 parts, herba epimedii 10-20 parts, herba rhizomatis 10-20 parts, angelica sinensis 10-20 parts, radix paeoniae alba 10-20 parts, radix rehmanniae praeparatae 10-20 parts, radix atractylodis 10-20 parts, radix cyathulae 10-20 parts, rhizoma notopterygii 3-12 parts, herba cynomorii 10-20 parts and centipede 1-3 parts. The traditional Chinese medicine composition can effectively solve the problems of the existing composition, such as unsatisfactory treatment effect and too many components.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for improving male sexual function, a traditional Chinese medicine preparation and a preparation method thereof. Background Art

[0002] Impotence refers to a condition in which a man's penis becomes flaccid and unable to erect, or becomes erect but not firm, or becomes erect but not long-lasting, resulting in an inability to complete normal sexual intercourse, which can last for more than three months, from the time of sexual maturity until his libido declines. Premature ejaculation, also known as ejaculation dysfunction, manifests as an inability to control ejaculation during intercourse, resulting in premature ejaculation, lasting less than two minutes. Impotence and premature ejaculation often overlap, forming a condition known as impotence and premature ejaculation. Modern medical treatments for impotence and premature ejaculation are at the forefront in the United States, with medication, circumcision, and sertraline being the primary treatments, but the effectiveness is often unsatisfactory.

[0003] With the changing pace and pace of modern life, the causes and mechanisms of impotence and premature ejaculation have also shifted. Excessive sexual activity weakens kidney yang, leading to erectile dysfunction and an inability to retain essence and blood. Excessive worry damages the heart and spleen, leading to insufficient qi and blood, malnourishing the tendons and causing erectile dysfunction. Depression and anxiety can lead to liver dysfunction, weakening the tendons and causing erectile dysfunction. An unhealthy diet can lead to accumulation of dampness and heat, which can flow downward and cause the tendons to become loose. Excessive sexual activity can lead to excessive fire, disturbing the essence chambers and causing impotence and premature ejaculation. In Traditional Chinese Medicine (TCM), the causes and mechanisms of impotence and premature ejaculation are categorized as either deficiency or excess. Deficiency is often due to insufficient kidney qi and essence, resulting in kidney yang and kidney yin deficiency, which is blamed on the kidneys. Excess is often caused by qi stagnation, dampness, phlegm congestion, and blood stasis. The kidneys govern the anterior and posterior yin meridians, the seat of essence. Failure to properly store and control these organs can lead to symptoms such as impotence, premature ejaculation, and spermatorrhea.

[0004] Traditional Chinese Medicine (TCM) often attributes impotence and premature ejaculation to kidney dysfunction and has established a "kidney-centered" approach to treatment. Treatment primarily focuses on kidney deficiency, prioritizing kidney yin and yang deficiency. Clinically, the approach is to nourish yin and warm yang, using Liuwei Dihuang Wan, Jinkui Shenqi Wan, or their derivatives. Folk medicines also combine kidney-tonifying and yang-strengthening herbs in hopes of achieving greater kidney-tonifying effects, but these combinations often have limited efficacy and can even lead to complications. Furthermore, these drugs are generally expensive, and using them in large quantities increases the financial burden on patients. Summary of the Invention

[0005] In view of the above-mentioned deficiencies in the prior art, the present invention provides a Chinese medicine composition, a Chinese medicine preparation and a preparation method thereof for improving male sexual function. The Chinese medicine composition can effectively solve the problems of unsatisfactory therapeutic effects and excessive ingredients in the existing compositions.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the present invention to solve the technical problem is:

[0007] A traditional Chinese medicine composition for improving male sexual function comprises the following components in parts by weight: 10-20 parts of dodder seeds, 10-20 parts of leek seeds, 3-12 parts of schisandra chinensis, 10-20 parts of raspberry, 10-20 parts of epimedium, 10-20 parts of curculigo, 10-20 parts of angelica, 10-20 parts of white peony, 10-20 parts of rehmannia root, 10-20 parts of atractylodes, 10-20 parts of cynomorium, 3-12 parts of notopterygium root, 10-20 parts of cynomorium songaricum and 1-3 parts of centipede.

[0008] Further, the invention includes the following components in parts by weight: 12-16 parts of Cuscuta seeds, 12-16 parts of Allium tuberosum seeds, 5-9 parts of Schisandra chinensis, 12-16 parts of Rubus idaeus, 12-16 parts of Epimedium, 12-16 parts of Curculigo orchioides, 12-16 parts of Angelica sinensis, 12-16 parts of White Peony Root, 12-16 parts of Rehmannia glutinosa, 12-16 parts of Atractylodes macrocephala, 12-16 parts of Achyranthes bidentata, 5-9 parts of Notopterygium wilfordii, 12-16 parts of Cynomorium songaricum and 2-3 parts of Scolopendra subspinipes.

[0009] Further, the invention comprises the following components in parts by weight: 12 parts of Cuscuta seeds, 12 parts of Allium tuberosum seeds, 5 parts of Schisandra chinensis, 12 parts of Rubus idaeus, 12 parts of Epimedium, 12 parts of Curculigo orchioides, 12 parts of Angelica sinensis, 12 parts of White Peony Root, 12 parts of Rehmannia glutinosa, 18 parts of Atractylodes macrocephala, 12 parts of Achyranthes bidentata, 5 parts of Notopterygium wilfordii, 12 parts of Cynomorium songaricum and 2 parts of Scolopendra subspinipes.

[0010] Further, the invention comprises the following components in parts by weight: 18 parts of Cuscuta seeds, 18 parts of Allium tuberosum seeds, 10 parts of Schisandra chinensis, 18 parts of Rubus idaeus, 18 parts of Epimedium, 18 parts of Curculigo orchioides, 18 parts of Angelica sinensis, 18 parts of White Peony Root, 18 parts of Rehmannia glutinosa, 18 parts of Atractylodes macrocephala, 18 parts of Achyranthes bidentata, 11 parts of Notopterygium wilfordii, 14 parts of Cynomorium songaricum and 3 parts of Scolopendra subspinipes.

[0011] Further, the invention comprises the following components in parts by weight: 16 parts of Cuscuta seeds, 16 parts of Allium tuberosum seeds, 9 parts of Schisandra chinensis, 16 parts of Rubus idaeus, 16 parts of Epimedium, 16 parts of Curculigo orchioides, 16 parts of Angelica sinensis, 16 parts of White Peony Root, 16 parts of Rehmannia glutinosa, 16 parts of Atractylodes macrocephala, 16 parts of Achyranthes bidentata, 9 parts of Notopterygium wilfordii, 16 parts of Cynomorium songaricum and 1 part of Scolopendra subspinipes.

[0012] Further, the invention comprises the following components in parts by weight: 16 parts of Cuscuta seeds, 14 parts of Allium tuberosum seeds, 7 parts of Schisandra chinensis, 18 parts of Rubus idaeus, 18 parts of Epimedium, 16 parts of Curculigo orchioides, 18 parts of Angelica sinensis, 18 parts of White Peony Root, 16 parts of Rehmannia glutinosa, 16 parts of Atractylodes macrocephala, 16 parts of Achyranthes bidentata, 9 parts of Notopterygium wilfordii, 16 parts of Cynomorium songaricum and 1 part of Scolopendra subspinipes.

[0013] A traditional Chinese medicine preparation for improving male sexual function comprises the above-mentioned traditional Chinese medicine composition.

[0014] Furthermore, it includes powders, granules, capsules, pills and tablets.

[0015] Furthermore, when the preparation is a granule, its preparation method is as follows: the above fourteen ingredients, centipede, are crushed into fine powder and set aside; the remaining thirteen ingredients are decocted twice, the filtrate is combined, and the filtrate is concentrated into a thick paste; the centipede fine powder, thick paste and auxiliary materials are made into granules to obtain the product.

[0016] The beneficial effects produced by the present invention are:

[0017] The traditional Chinese medicine composition of the present invention has the effects of warming the kidney and strengthening yang, promoting blood circulation and removing blood stasis, nourishing essence and consolidating the body. It has a good therapeutic effect on patients with functional impotence, premature ejaculation, spermatorrhea, enuresis and neurasthenia of kidney yang deficiency and kidney yin deficiency type, with symptoms such as fatigue, soreness of the waist and knees, coldness of the lower abdomen and genitals, low libido, cold semen and slippery discharge. In addition, the number of medicinal ingredients in the composition of the present invention is relatively small, and there are no precious traditional Chinese medicinal materials, which can effectively reduce the economic burden of patients.

[0018] In the composition, Cuscuta has the effects of nourishing the liver and kidney, consolidating essence and reducing urine; Curculigo has the effects of nourishing kidney yang, warming spleen yang, and removing cold and dampness; Epimedium has the effects of nourishing the kidney and strengthening yang, and removing wind and dampness; Allium sibiricum has the effects of warming and nourishing the liver and kidney, strengthening yang and consolidating essence; Cynomorium songaricum has the effects of nourishing kidney yang and benefiting essence and blood; Rubus idaeus has the effects of nourishing the kidney, consolidating essence and reducing urine, and nourishing the liver; the above medicinal materials are used together as the main medicine to achieve the purpose of nourishing the kidney and strengthening yang, and have a good therapeutic effect on male impotence and premature ejaculation.

[0019] Schisandra chinensis has the effects of astringing, strengthening qi and promoting fluid production, and nourishing the kidney and yin; Angelica sinensis has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain; White Peony Root has the effects of calming the liver and relieving pain, astringing yin and stopping sweating, and is a tonic; Rehmannia glutinosa has the effects of nourishing blood and yin, and replenishing essence and filling marrow; Achyranthes bidentata has the effects of nourishing the liver and kidney, strengthening tendons and bones, activating blood circulation and promoting menstruation, and guiding fire downward. The above herbs are used together as ministerial drugs to nourish kidney yin and kidney essence through the effects of nourishing yin, nourishing yin, astringing yin, and replenishing essence and filling marrow. While the monarch drug nourishes kidney yang, it also nourishes kidney yin, and tonifies yin and yang at the same time, avoiding other diseases induced by excessive yang and insufficient yin.

[0020] Atractylodes macrocephala has the effect of strengthening the spleen and eliminating dampness. Using it as an adjuvant can help the main and auxiliary medicines to nourish the kidney yin and kidney yang; centipede has the effect of removing blood stasis, promoting blood circulation and unblocking the meridians, and Notopterygium incisum has the effect of dispelling wind, activating blood circulation and dilating blood vessels. Centipede and Notopterygium incisum are used as guiding medicines to lead the medicine directly to the genitals, thereby improving the overall effect of the medicine.

[0021] The various medicinal ingredients in the composition of the present invention complement and interact with each other, resulting in an excellent overall effect on enhancing male sexual performance due to kidney yang and kidney yin deficiency. In cases of kidney yang deficiency, appropriately nourishing kidney essence and kidney yin not only cultivates yang within yin, but also prevents adverse reactions such as "burning out of the pot" caused by simply replenishing kidney yang. In cases of kidney yin deficiency, appropriately warming yang can often accelerate drug absorption through the warming and stimulating properties of the main medicinal ingredient, promoting recovery. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. That is, the embodiments described are only part of the embodiments of the present invention, rather than all embodiments.

[0023] Therefore, the detailed description of the embodiments of the present invention provided below is not intended to limit the scope of the invention as claimed, but is merely intended to represent selected embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative work are within the scope of protection of the present invention.

[0024] It should be noted that relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or apparatus comprising the element.

[0025] The features and performance of the present invention are further described in detail below with reference to the embodiments.

[0026] Example 1

[0027] A traditional Chinese medicine composition for improving male sexual function is composed of the following components in parts by weight: 10g of Cuscuta seeds, 10g of Allium tuberosum seeds, 3g of Schisandra chinensis, 10g of Rubus idaeus, 10g of Epimedium, 10g of Curculigo orchioides, 10g of Angelica sinensis, 10g of White Peony Root, 10g of Rehmannia glutinosa, 10g of Atractylodes macrocephala, 10g of Achyranthes bidentata, 3g of Notopterygium wilfordii, 10g of Cynomorium songaricum, and 1 Scolopendra subspinipes.

[0028] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0029] Example 2

[0030] A traditional Chinese medicine composition for improving male sexual function is composed of the following components in parts by weight: 20g of Cuscuta seeds, 20g of Allium tuberosum seeds, 12g of Schisandra chinensis, 20g of Rubus idaeus, 20g of Epimedium, 20g of Curculigo orchioides, 20g of Angelica sinensis, 20g of White Peony Root, 20g of Rehmannia glutinosa, 20g of Atractylodes macrocephala, 20g of Achyranthes bidentata, 12g of Notopterygium wilfordii, 20g of Cynomorium songaricum, and 3 centipedes.

[0031] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0032] Example 3

[0033] A traditional Chinese medicine composition for improving male sexual function is composed of the following components in parts by weight: 12g of Cuscuta seeds, 12g of Allium tuberosum seeds, 5g of Schisandra chinensis, 12g of Rubus idaeus, 12g of Epimedium, 12g of Curculigo orchioides, 12g of Angelica sinensis, 12g of White Peony Root, 12g of Rehmannia glutinosa, 18g of Atractylodes macrocephala, 12g of Achyranthes bidentata, 5g of Notopterygium wilfordii, 12g of Cynomorium songaricum, and 2 centipedes.

[0034] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0035] Example 4

[0036] A traditional Chinese medicine composition for improving male sexual function is composed of the following components in parts by weight: 18g of Cuscuta seeds, 18g of Allium tuberosum seeds, 10g of Schisandra chinensis, 18g of Rubus idaeus, 18g of Epimedium, 18g of Curculigo orchioides, 18g of Angelica sinensis, 18g of White Peony Root, 18g of Rehmannia glutinosa, 18g of Atractylodes macrocephala, 18g of Achyranthes bidentata, 11g of Notopterygium wilfordii, 14g of Cynomorium songaricum, and 3 centipedes.

[0037] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0038] Example 5

[0039] A traditional Chinese medicine composition for improving male sexual function is composed of the following components in parts by weight: 16g of Cuscuta seeds, 16g of Allium tuberosum seeds, 9g of Schisandra chinensis, 16g of Rubus idaeus, 16g of Epimedium, 16g of Curculigo orchioides, 16g of Angelica sinensis, 16g of White Peony Root, 16g of Rehmannia glutinosa, 16g of Atractylodes macrocephala, 16g of Achyranthes bidentata, 9g of Notopterygium wilfordii, 16g of Cynomorium songaricum, and 1 Scolopendra subspinipes.

[0040] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0041] Example 6

[0042] A traditional Chinese medicine composition for improving male sexual function is composed of the following components in parts by weight: 16g of Cuscuta seeds, 14g of Allium tuberosum seeds, 7g of Schisandra chinensis, 18g of Rubus idaeus, 18g of Epimedium, 16g of Curculigo orchioides, 18g of Angelica sinensis, 18g of White Peony Root, 16g of Rehmannia root, 16g of Atractylodes macrocephala, 16g of Achyranthes bidentata, 9g of Notopterygium wilfordii, 16g of Cynomorium songaricum, and 1 Scolopendra subspinipes.

[0043] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0044] Comparative Example 1

[0045] A traditional Chinese medicine composition for improving male sexual function comprises the following components in parts by weight: 16g of Cuscuta seeds, 16g of Allium tuberosum seeds, 14g of Schisandra chinensis, 16g of Rubus idaeus, 8g of Epimedium, 16g of Curculigo orchioides, 16g of Angelica sinensis, 16g of White Peony Root, 16g of Rehmannia glutinosa, 16g of Atractylodes macrocephala, 16g of Achyranthes bidentata, 9g of Notopterygium wilfordii, 8g of Cynomorium songaricum, and 1 Scolopendra subspinipes.

[0046] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0047] Comparative Example 2

[0048] A traditional Chinese medicine composition for improving male sexual function comprises the following components in parts by weight: 16g of dodder seed, 16g of leek seed, 9g of schisandra chinensis, 16g of raspberry, 16g of epimedium, 16g of curculigo, 5g of angelica, 5g of white peony root, 16g of prepared rehmannia root, 16g of atractylodes, 5g of cynomorium root, 9g of notopterygium root, 16g of cynomorium songaricum, and 1 centipede.

[0049] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0050] Comparative Example 3

[0051] A traditional Chinese medicine composition for improving male sexual function comprises the following components in parts by weight: 16g of dodder seed, 16g of leek seed, 9g of schisandra chinensis, 16g of raspberry, 16g of epimedium, 16g of curculigo, 16g of angelica, 16g of white peony root, 16g of rehmannia root, 16g of atractylodes macrocephala, 16g of cynomorium root, 9g of angelica root, 16g of angelica songaricum, and 1 centipede.

[0052] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0053] Comparative Example 4

[0054] A traditional Chinese medicine composition for improving male sexual function comprises the following components in parts by weight: 16g of dodder seed, 16g of leek seed, 9g of schisandra chinensis, 16g of raspberry, 16g of epimedium, 16g of curculigo, 16g of angelica, 16g of white peony root, 16g of rehmannia root, 16g of atractylodes macrocephala, 16g of cynomorium root, 9g of notopterygium root, 16g of cynomorium songaricum, 1 earthworm, and 2 seahorses.

[0055] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0056] Comparative Example 5

[0057] A traditional Chinese medicine composition for improving male sexual function comprises the following components in parts by weight: 16g of dodder seed, 16g of leek seed, 9g of schisandra chinensis, 16g of raspberry fruit, 16g of epimedium, 16g of curculigo, 16g of angelica, 16g of white peony root, 16g of rehmannia root, 16g of euryale fruit, 16g of cyperus rotundus, 16g of achyranthes bidentata, 9g of notopterygium root, 16g of cynomorium songaricum, and 1 centipede.

[0058] A traditional Chinese medicine granule for improving male sexual function, the preparation method of which is as follows: the centipede of the above 14 ingredients is crushed into fine powder and set aside; the remaining 13 ingredients are soaked for 1 hour before decoction, and water is added and decocted twice, the first time with 10 times the amount of water and decocted for 1 hour, and the second time with 8 times the amount of water and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and auxiliary materials are made into granules to obtain the product.

[0059] Test example

[0060] Patients aged 28-60 years who came to the hospital for treatment with symptoms such as impotence and premature ejaculation, enuresis, low libido, and weakness in the waist and knees were collected and randomly divided into 6 groups, 20 people in each group. Each group of patients was given the Chinese medicine preparations in Example 5 and Comparative Examples 1-5 three times a day, 5 g each time, for 3 consecutive courses of treatment, each course of treatment lasting 5 days. The symptom changes of each group of patients were observed and statistically recorded.

[0061] Clinical symptoms, signs, and assessment results

[0062]

[0063] Efficacy evaluation criteria

[0064] ①Clinical control efficacy index ≥95%.

[0065] ② Markedly effective 70% ≤ efficacy index < 95%.

[0066] ③ Effectiveness 30% ≤ efficacy index < 70%.

[0067] ④ Ineffective efficacy index <30%.

[0068] Efficacy index (n) = (total score before treatment - total score after treatment) / total score before treatment * 100%

[0069] After the treatment, the average treatment status of each group of patients is shown in Table 1.

[0070] Table 1: Treatment status of different patients

[0071]

[0072] It can be seen from the above table that the therapeutic effect of the Chinese medicine preparation in Example 5 is significantly better than that of the Chinese medicine preparation in Comparative Examples 1-5. Compared with the composition in Example 5, the specific ingredients and dosages of the compositions in Comparative Examples 1-5 have certain changes. It can be seen from the efficacy evaluation results that there is an interaction between the drugs in the Chinese medicine composition of the present application, which can effectively improve the therapeutic effect while using less medicinal flavors.

[0073] Compared with Example 5, Comparative Example 1 increases the dosage of Schisandra chinensis, and reduces the dosage of Epimedium and Cynomorium songaricum. It can be seen from the therapeutic effect that the therapeutic effect of the adjusted composition decreases. The reason may be that after the dosage of Epimedium and Cynomorium songaricum is reduced, the mutual coordination between the compositions is reduced, resulting in a decrease in the overall kidney-tonifying and yang-strengthening efficacy of the composition. Although the dosage of Schisandra chinensis is increased, Schisandra chinensis mainly plays the role of astringing sperm, and its kidney-tonifying ability is limited. Therefore, the overall therapeutic effect of the adjusted composition is reduced.

[0074] Compared with Example 5, Comparative Example 2 reduces the dosage of Angelica sinensis, White Peony Root and Achyranthes Bidentata; it can be seen from the therapeutic effect that the therapeutic effect of the adjusted composition decreases. The reason may be that after the dosage of Angelica sinensis and White Peony Root is reduced, the overall blood-tonifying, blood-activating and analgesic efficacy of the composition is reduced, blood deficiency and poor circulation affect the transmission of drugs, reduce the nourishment to the kidneys and genitals, and affect the therapeutic effect; the reduction in the dosage of Achyranthes Bidentata will also reduce the nourishing effect of the composition on the liver and kidneys, affecting the overall therapeutic effect of the composition.

[0075] Compared with Example 5, Comparative Example 3 replaces Notopterygium wilfordii with Duhuo radix; it can be seen from the therapeutic effect that the therapeutic effect of the adjusted composition decreases. The reason may be that Notopterygium wilfordii has a stronger effect than Duhuo radix in dispelling wind and relieving exterior symptoms and dilating blood vessels. The use of Notopterygium wilfordii can dilate the patient's blood vessels, smooth blood flow, and timely drug delivery, thereby improving the therapeutic effect and improving the overall therapeutic effect of the composition.

[0076] Comparative Example 4 is compared with Example 5, in which the centipede is replaced by seahorse and earthworm; it can be seen from the therapeutic effect that the therapeutic effect of the adjusted composition decreases. The reason may be that although centipede, seahorse and earthworm are all animal medicines, centipede is warm in nature and has an auxiliary effect on warming and tonifying kidney yang, and centipede focuses on promoting blood circulation and activating collaterals, which can improve the effect of strengthening tendons and bones; while the efficacy of seahorse and earthworm is not as good as that of centipede in promoting blood circulation and activating collaterals, resulting in a decrease in the overall therapeutic effect of the composition after replacement.

[0077] Compared with Example 5, Comparative Example 5 replaces Atractylodes macrocephala with Euryale ferox; it can be seen from the therapeutic effect that the therapeutic effect of the adjusted composition decreases. The reason may be that the dampness-removing and qi-invigorating effect of Euryale ferox is worse than that of Atractylodes macrocephala, resulting in the overall dampness-removing and qi-invigorating effect of the composition being worse, insufficient qi and blood replenishment, and poor blood flow, resulting in the overall therapeutic effect of the composition being worse.

[0078] Typical Cases

[0079] Case 1: Patient Jiang, male, 28 years old, reported that he masturbated too much 2 years ago, resulting in short sexual life, insufficient penis hardness, difficulty in erection, weakness, and fatigue in the middle; occasional bifurcated urine; after taking local Chinese medicine for a period of time, he felt no obvious effect; during the face-to-face consultation, the patient had teeth marks on the edge of the tongue coating and the tongue was pale. The patient had no symptoms of palpitations, hand tremors, fear of heat, and sweating. He was diagnosed with sexual dysfunction caused by spleen and kidney yang deficiency. The Chinese medicine composition of this application was prescribed for the patient. After taking it for 15 days, the patient felt that his sexual endurance increased, the quality of his sexual life improved, and his spirits improved.

[0080] Case 2: Patient Ling, male, 36 years old, reported that he had short intercourse time without obvious inducement, insufficient penis hardness, symptoms of fatigue during intercourse, poor sleep, and occasional frequent urination and urgency; during the face-to-face consultation, the patient's tongue coating was thick and greasy, with cracks in the middle of the tongue coating. The patient had no symptoms such as palpitations, hand tremors, intolerance to heat and sweating. He was diagnosed with sexual dysfunction caused by insufficient kidney essence, weak kidney qi, and deficiency of both spleen and kidney. The Chinese medicine composition in this application was prescribed for him. After taking it for 15 days, the patient felt that the quality of his sexual life was improved, the quality of his sleep was improved, the symptoms of frequent urination and urgency disappeared, and his spirit was improved.

[0081] Case 3: Patient Ran, male, 50 years old, reported that he had symptoms of premature ejaculation, weak ejaculation, and penis flaccidity without obvious causes 1 year ago; he was easily sleepy after ejaculation, had poor sleep quality, and had frequent urination and nocturia. He bought avanafil on his own and it had some effect after taking it, but the effect was short-lived; he came to our hospital for treatment, and the patient was found to have a slightly yellow tongue coating and a deep pulse, without symptoms of palpitations, hand tremors, heat intolerance, and sweating. He was diagnosed with sexual dysfunction caused by heart-kidney disharmony and spleen-kidney deficiency. He was prescribed the Chinese medicine composition in this application, and after taking it for 15 days, he reported that his symptoms had improved.

[0082] Case 4: Patient Wang, male, 53 years old, reported that he had short sexual intercourse time without obvious inducement 1 year ago, and was prone to fatigue during intercourse. He took kidney-tonifying medicine on his own, but there was no obvious effect. He came to our hospital for treatment. During the face-to-face consultation, his tongue was red, without coating, and his pulse was sluggish. He had no symptoms of palpitations, hand tremors, heat intolerance, and sweating. He was diagnosed with sexual dysfunction caused by spleen and kidney deficiency. The composition of this application was prescribed for him. After taking it for 15 days, the patient reported in a follow-up examination that he had morning erections, and the hardness of his penis increased during intercourse, and his symptoms were improved.

[0083] Case 5: Patient Zhang, male, 46 years old, reported that he had premature ejaculation without obvious cause half a year ago, with few morning erections, occasional frequent urination and urgency, fatigue after sex, and symptoms gradually worsened over time; he came to our hospital for treatment, and during the face-to-face consultation, the patient's tongue coating was yellow and greasy, with teeth marks on the edges. The patient had no symptoms of palpitations, hand tremors, heat intolerance, and sweating. He was diagnosed with sexual dysfunction caused by insufficient kidney essence, weak kidney qi, deficiency of both spleen and kidney, and stasis of qi and blood. The Chinese medicine composition in this application was prescribed for him, and the patient reported that various symptoms were improved after taking it for half a month.

[0084] Case 6: Patient Zhang, male, 40 years old, reported that he had symptoms such as premature ejaculation, penis fatigue, sensitive glans, short intercourse time, weak ejaculation, and erectile dysfunction without obvious causes half a year ago, and he was easily sleepy after intercourse; his scrotum was moist, he had occasional tinnitus, loose stools, and bad breath; the effect of taking Chinese medicine prescribed by the clinic was not obvious, so he came to our hospital for treatment. During the face-to-face consultation, the patient had a large tongue, greasy tongue coating, and a stringy pulse. He had no symptoms of palpitations, hand tremors, heat intolerance, and sweating. He was diagnosed with sexual dysfunction caused by heart-kidney disharmony and spleen-kidney deficiency. He was prescribed the composition in this application. The patient reported that the quality of his intercourse improved after taking it for half a month, and all other symptoms disappeared.

[0085] Case 7: Patient Zhang, male, 38 years old, had no obvious cause and had short sexual intercourse time, easy fatigue in the middle, bifurcated urine, yellow urine, disappearance of morning erection, frequent urination and urgency 3 years ago, but no treatment; he came to our hospital for treatment. During the face-to-face examination, the patient had a pale tongue with teeth marks on the edges, a sluggish pulse, no symptoms of palpitations, hand tremors, heat intolerance, and sweating. He was diagnosed with sexual dysfunction caused by spleen and kidney deficiency, and was prescribed the composition in this application. The patient reported that his symptoms improved after taking the medicine for half a month.

Claims

1. A Chinese medicine composition for improving male sexual function, characterized in that: The invention is composed of the following components in parts by weight: 10-20 parts of Cuscuta seeds, 10-20 parts of Allium tuberosum seeds, 3-12 parts of Schisandra chinensis, 10-20 parts of Rubus idaeus, 10-20 parts of Epimedium, 10-20 parts of Curculigo orchioides, 10-20 parts of Angelica sinensis, 10-20 parts of White Peony Root, 10-20 parts of Rehmannia glutinosa, 10-20 parts of Atractylodes macrocephala, 10-20 parts of Achyranthes bidentata, 3-12 parts of Notopterygium wilfordii, 10-20 parts of Cynomorium songaricum and 1-3 parts of Scolopendra subspinipes.

2. The Chinese medicine composition for improving male sexual function according to claim 1, wherein The invention is composed of the following components in parts by weight: 12-16 parts of Cuscuta seeds, 12-16 parts of Allium tuberosum seeds, 5-9 parts of Schisandra chinensis, 12-16 parts of Rubus idaeus, 12-16 parts of Epimedium, 12-16 parts of Curculigo orchioides, 12-16 parts of Angelica sinensis, 12-16 parts of White Peony Root, 12-16 parts of Rehmannia glutinosa, 12-16 parts of Atractylodes macrocephala, 12-16 parts of Achyranthes bidentata, 5-9 parts of Notopterygium wilfordii, 12-16 parts of Cynomorium songaricum and 2-3 parts of Scolopendra subspinipes.

3. The Chinese medicine composition for improving male sexual function according to claim 1, wherein The invention is composed of the following components in parts by weight: 12 parts of Cuscuta seeds, 12 parts of Allium tuberosum seeds, 5 parts of Schisandra chinensis, 12 parts of Rubus idaeus, 12 parts of Epimedium, 12 parts of Curculigo orchioides, 12 parts of Angelica sinensis, 12 parts of White Peony Root, 12 parts of Rehmannia glutinosa, 18 parts of Atractylodes macrocephala, 12 parts of Achyranthes bidentata, 5 parts of Notopterygium wilfordii, 12 parts of Cynomorium songaricum and 2 parts of Scolopendra subspinipes.

4. The Chinese medicine composition for improving male sexual function according to claim 1, wherein The invention is composed of the following components in parts by weight: 18 parts of Cuscuta seeds, 18 parts of Allium tuberosum seeds, 10 parts of Schisandra chinensis, 18 parts of Rubus idaeus, 18 parts of Epimedium, 18 parts of Curculigo orchioides, 18 parts of Angelica sinensis, 18 parts of White Peony Root, 18 parts of Rehmannia glutinosa, 18 parts of Atractylodes macrocephala, 18 parts of Achyranthes bidentata, 11 parts of Notopterygium wilfordii, 14 parts of Cynomorium songaricum and 3 parts of Scolopendra subspinipes.

5. The Chinese medicine composition for improving male sexual function according to claim 1, wherein The invention is composed of the following components in parts by weight: 16 parts of Cuscuta seeds, 16 parts of Allium tuberosum seeds, 9 parts of Schisandra chinensis, 16 parts of Rubus idaeus, 16 parts of Epimedium, 16 parts of Curculigo orchioides, 16 parts of Angelica sinensis, 16 parts of White Peony Root, 16 parts of Rehmannia glutinosa, 16 parts of Atractylodes macrocephala, 16 parts of Achyranthes bidentata, 9 parts of Notopterygium wilfordii, 16 parts of Cynomorium songaricum and 1 part of Scolopendra subspinipes.

6. The Chinese medicine composition for improving male sexual function according to claim 1, wherein The invention is composed of the following components in parts by weight: 16 parts of Cuscuta seeds, 14 parts of Allium tuberosum seeds, 7 parts of Schisandra chinensis, 18 parts of Rubus idaeus, 18 parts of Epimedium, 16 parts of Curculigo orchioides, 18 parts of Angelica sinensis, 18 parts of White Peony Roots, 16 parts of Rehmannia glutinosa, 16 parts of Atractylodes macrocephala, 16 parts of Achyranthes bidentata, 9 parts of Notopterygium wilfordii, 16 parts of Cynomorium songaricum and 1 part of Scolopendra subspinipes.

7. A Chinese medicine preparation for improving male sexual function, characterized in that: Prepared from the Chinese medicine composition according to any one of claims 1 to 6.

8. The Chinese medicinal preparation for improving male sexual function according to claim 7, wherein Including powders, granules, capsules, pills and tablets.

9. The Chinese medicinal preparation for improving male sexual function according to claim 8, characterized in that When the preparation is a granule, the preparation method is as follows: the centipede of the above fourteen ingredients is crushed into fine powder and set aside; the remaining thirteen ingredients are decocted twice, the filtrates are combined, and the filtrates are concentrated into a thick paste; the centipede fine powder, the thick paste and the auxiliary materials are made into granules to obtain the preparation.

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