Whitening skin care composition, whitening cream and preparation method

Abstract

The present invention relates to the field of daily chemical technology, and in particular to a whitening skin care composition, a whitening cream and a preparation method. The present invention provides a whitening skin care composition, and its components include: A phase raw materials: water, glycerol, butylene glycol, niacinamide, acetyl glucosamine, panthenol, sodium hyaluronate; B phase raw materials: 3, cetyl ethylhexanoate, cetearyl alcohol, cetearyl glucoside, polydimethylsiloxane, isohexadecane, aluminum hydroxide, PEG-100 stearate, glyceryl stearate, tocopherol acetate, jojoba seed oil; C phase raw materials: polyacrylamide, C13-14 isoparaffin, laureth-7, water; D phase raw materials: water, soluble collagen cross-linked polymer, 1,2-hexanediol, p-hydroxyacetophenone, and encapsulation components. The whitening composition and whitening cream provided by the present invention have good whitening and moisturizing effects, stable product performance, and are not easy to discharge water; and no stimulation or allergic reaction is produced after use.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemicals, in particular to a whitening skin care composition, a whitening cream and a preparation method. Background Art

[0002] At present, anti-aging and whitening have become two major focuses of people's daily attention. Long-term exposure of the skin to ultraviolet rays and other stimuli will accelerate skin aging and produce a large amount of melanin.

[0003] The whitening ingredients currently used include: niacinamide, arbutin, vitamin C, asiatica glycoside, azelaic acid, hydroquinone, vitamin B derivatives, tranexamic acid, etc. There are many types, but there are some well-known problems in the industry: the whitening content cannot be too high, and a high content will irritate the skin and cause some allergic reactions. Therefore, users need to build tolerance, and slowly increase the concentration after the skin gradually accepts low-concentration stimulation. However, many users still have allergic reactions.

[0004] In addition, the time from opening a cosmetic to using it up can often be as short as one month or as long as half a year, and it will experience different temperatures; therefore, the preservation of the cosmetics after they come into contact with air during the storage period and the stability of their physical properties are also areas that the industry has been working on.

[0005] In view of the above situation, the present invention provides a whitening skin care composition, a whitening cream and a preparation method. Summary of the invention

[0006] The object of the present invention is to provide a whitening skin care composition, the components of which include:

[0007] Phase A ingredients: water, glycerin, butylene glycol, niacinamide, acetyl glucosamine, panthenol, sodium hyaluronate;

[0008] Phase B ingredients: cetyl ethylhexanoate, cetearyl alcohol, cetearyl glucoside, dimethicone, isohexadecane, aluminum hydroxide, PEG-100 stearate, glyceryl stearate, tocopheryl acetate, jojoba seed oil;

[0009] Phase C raw materials: polyacrylamide, C13-14 isoparaffin, laureth-7, water

[0010] Phase D raw materials: water, soluble collagen cross-linked polymer, 1,2-hexanediol, p-hydroxyacetophenone, encapsulating components;

[0011] E phase raw materials: butanediol, p-hydroxyacetophenone, 1,2-hexanediol;

[0012] Phase F raw materials: yellow inclusions, green inclusions.

[0013] As an embodiment of the present invention, in the phase D raw material, the wrapping component comprises: wrapping component 1 and wrapping component 2;

[0014] Wherein, the wrapping component 1 comprises: water, caprylic / capric triglyceride, steareth-21, phenethyl resorcinol, glyceryl polyether-26, ethoxydiglycol, polysorbate-80, laureth-23, cocoyl glucoside, coconut alcohol, PEG-40 stearate, butyloctanol salicylate, butylene glycol, steareth-2, sorbitan stearate, diethylhexyl eugenylmalonate, butylated hydroxytoluene, disodium EDTA;

[0015] Package component 2 contains: water, alpha-arbutin, niacinamide, polyglyceryl-4 oleate, isononyl isononanoate, coco-glucoside, 3-o-ethyl ascorbic acid, tocopheryl acetate, glycerin, butylene glycol, glycyrrhetinic acid, lecithin, 1,2-hexanediol, caprylyl glycol.

[0016] As an embodiment of the present invention, the mass ratio of the package component 1 to the package component 2 is (3-5):3.

[0017] As an embodiment of the present invention, in the phase F raw material, the components of the yellow inclusions are:

[0018] Water, Caprylic / Capric Triglyceride, Squalane, Butylene Glycol, Glycerin, 1,2-Hexanediol, Caprylyl Glycol, Sodium Alginate, Beta-Carotene, Acrylates / C10-30 Alkyl Acrylate Crosspolymer.

[0019] As an embodiment of the present invention, in the phase F raw material, the components of the green inclusions are:

[0020] Caprylic / capric triglyceride, water, squalane, butylene glycol, glycerin, 1,2-hexanediol, caprylyl glycol, sodium alginate, copper chlorophyllin, acrylates / C10-30 alkyl acrylate crosspolymer.

[0021] As an embodiment of the present invention, the phase B raw material further comprises encapsulation aids: aloe vera leaf extract and vitamin E.

[0022] As an embodiment of the present invention, the mass ratio of the encapsulating auxiliary agent to the encapsulating component is 8:(30-40).

[0023] As an embodiment of the present invention, the mass ratio of the encapsulating auxiliary agent to the encapsulating component is 8:35.

[0024] As a preferred embodiment of the present invention, the phase B raw material further comprises soybean (Glycine Soja) oil.

[0025] The second aspect of the present invention provides a whitening cream prepared from the whitening skin care composition.

[0026] As an embodiment of the present invention, the preparation method of the whitening cream is as follows:

[0027] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0028] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0029] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0030] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0031] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0032] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0033] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0034] By adopting the above technical solution, the present invention has the following beneficial effects:

[0035] The whitening composition and whitening cream provided by the present invention have good whitening and moisturizing effects, stable product performance, and are not easy to release water; and no irritation or allergic reaction occurs after use. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0037] Figure 1 Product picture corresponding to Example 1.

[0038] Figure 2 Product picture corresponding to Example 1. DETAILED DESCRIPTION

[0039] The technical solution of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0040] Example 1

[0041] This embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0042] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0043] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0044] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0045] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0046] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0047] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0048] The preparation method of the whitening cream is as follows:

[0049] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0050] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0051] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0052] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0053] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0054] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0055] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0056] Wherein, in the D phase raw material, the wrapping component comprises: wrapping component 1 and wrapping component 2;

[0057] Wherein, the encapsulation component 1 comprises: 0.08 parts of water, 0.0255 parts of caprylic / capric triglyceride, 0.011 parts of steareth-21, 0.01 parts of phenethyl resorcinol, 0.01 parts of glyceryl ether-26, 0.0006 parts of ethoxydiglycol, 0.006 parts of polysorbate-800, 0.006 parts of laureth-23, 0.006 parts of coco-glucoside, 0.006 parts of coconut alcohol, 0.006 parts of PEG-40 stearate, 0.006 parts of butyloctanol salicylate, 0.006 parts of butylene glycol, 0.006 parts of steareth-20, 0.006 parts of sorbitan stearate, 0.0006 parts of diethylhexyl syringylidenemalonate, 0.0006 parts of butylated hydroxytoluene, and 0.0003 parts of disodium EDTA;

[0058] Package component 2 contains: 0.0876 parts of water, 0.015 parts of α-arbutin, 0.015 parts of niacinamide, 0.0075 parts of polyglyceryl-4 oleate, 0.0075 parts of isononyl isononanoate, 0.0045 parts of cocoyl glucoside, 0.003 parts of 3-o-ethyl ascorbic acid, 0.003 parts of tocopheryl acetate, 0.003 parts of glycerin, 0.003 parts of butylene glycol, 0.0003 parts of glycyrrhetinic acid, 0.0003 parts of lecithin, 0.00015 parts of 1,2-hexanediol, and 0.00015 parts of caprylyl glycol.

[0059] In this embodiment, the packaged component 1 and the packaged component 2 are stirred and mixed at 45 degrees Celsius respectively, and then added to the remaining phase D raw materials to participate in the preparation.

[0060] The components of the yellow wrapping are:

[0061] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0062] The components of the green wrapping are:

[0063] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0064] The raw materials of the yellow wrapped material and the green wrapped material are respectively stirred evenly and then added into the reaction.

[0065] Meanwhile, in this embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

[0066] Example 2

[0067] The difference from Example 1 is that this embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0068] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0069] Phase B raw materials: 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0070] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0071] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0072] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0073] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0074] Example 3

[0075] The difference between this embodiment and embodiment 1 is that this embodiment provides a whitening cream, and its preparation raw materials include, in parts by mass:

[0076] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0077] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0078] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0079] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0080] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0081] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0082] Example 4

[0083] The difference between this embodiment and embodiment 1 is that this embodiment provides a whitening cream, and its preparation raw materials include, in parts by mass:

[0084] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0085] Phase B raw materials: 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0086] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0087] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0088] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0089] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0090] Example 5

[0091] The difference between this embodiment and embodiment 1 is that this embodiment provides a whitening cream, and its preparation raw materials include, in parts by mass:

[0092] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0093] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0094] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0095] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0096] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0097] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0098] Meanwhile, in the present embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are not mixed uniformly in advance, but are directly added to the phase B material to participate in the reaction.

[0099] Example 6

[0100] This embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0101] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0102] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0103] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0104] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0105] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0106] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0107] The preparation method of the whitening cream is as follows:

[0108] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0109] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0110] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0111] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0112] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0113] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0114] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0115] Wherein, in the D phase raw material, the wrapping component comprises: wrapping component 1 and wrapping component 2;

[0116] Wherein, the encapsulation component 1 comprises: 0.08 parts of water, 0.0255 parts of caprylic / capric triglyceride, 0.011 parts of steareth-21, 0.01 parts of phenethyl resorcinol, 0.01 parts of glyceryl ether-26, 0.0006 parts of ethoxydiglycol, 0.006 parts of polysorbate-800, 0.006 parts of laureth-23, 0.006 parts of coco-glucoside, 0.006 parts of coconut alcohol, 0.006 parts of PEG-40 stearate, 0.006 parts of butyloctanol salicylate, 0.006 parts of butylene glycol, 0.006 parts of steareth-20, 0.006 parts of sorbitan stearate, 0.0006 parts of diethylhexyl syringylidenemalonate, 0.0006 parts of butylated hydroxytoluene, and 0.0003 parts of disodium EDTA;

[0117] Package component 2 contains: 0.0876 parts of water, 0.015 parts of α-arbutin, 0.015 parts of niacinamide, 0.0075 parts of polyglyceryl-4 oleate, 0.0075 parts of isononyl isononanoate, 0.0045 parts of cocoyl glucoside, 0.003 parts of 3-o-ethyl ascorbic acid, 0.003 parts of tocopheryl acetate, 0.003 parts of glycerin, 0.003 parts of butylene glycol, 0.0003 parts of glycyrrhetinic acid, 0.0003 parts of lecithin, 0.00015 parts of 1,2-hexanediol, and 0.00015 parts of caprylyl glycol.

[0118] In this embodiment, the package component 1 and the package component 2 are not stirred and mixed in advance, but are directly added to the phase D raw material to participate in the preparation.

[0119] The components of the yellow wrapping are:

[0120] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0121] The components of the green wrapping are:

[0122] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0123] The raw materials of the yellow wrapped material and the green wrapped material are respectively stirred evenly and then added into the reaction.

[0124] Meanwhile, in this embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

[0125] Example 7

[0126] This embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0127] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0128] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0129] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0130] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0131] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0132] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0133] The preparation method of the whitening cream is as follows:

[0134] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0135] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0136] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0137] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0138] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0139] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0140] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0141] Wherein, in the D phase raw material, the wrapping component comprises: wrapping component 1;

[0142] Wherein, the encapsulation component 1 comprises: 0.1856 parts of water, 0.027 parts of caprylic / capric triglyceride, 0.018 parts of steareth-21, 0.03 parts of phenylethyl resorcinol, 0.0125 parts of glyceryl ether-26, 0.0007 parts of ethoxydiglycol, 0.007 parts of polysorbate-800, 0.01 parts of laureth-23, 0.007 parts of coco-glucoside, 0.007 parts of coconut alcohol, 0.011 parts of PEG-40 stearate, 0.0077 parts of butyloctanol salicylate, 0.007 parts of butylene glycol, 0.011 parts of steareth-20, 0.007 parts of sorbitan stearate, 0.0006 parts of diethylhexyl syringylidenemalonate, 0.0006 parts of butylated hydroxytoluene, and 0.0003 parts of disodium EDTA;

[0143] In this embodiment, the encapsulated component 1 is stirred and mixed uniformly at 45 degrees Celsius, and then added to the remaining phase D raw materials to participate in the preparation.

[0144] The components of the yellow wrapping are:

[0145] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0146] The components of the green wrapping are:

[0147] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0148] The raw materials of the yellow wrapped material and the green wrapped material are respectively stirred evenly and then added into the reaction.

[0149] Meanwhile, in this embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

[0150] Example 8

[0151] This embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0152] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0153] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0154] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0155] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0156] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0157] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0158] The preparation method of the whitening cream is as follows:

[0159] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0160] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0161] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0162] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0163] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0164] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0165] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0166] Wherein, in the phase D raw material, the encapsulating component comprises encapsulating component 2;

[0167] Package component 2 contains: 0.1702 parts of water, 0.3 parts of α-arbutin, 0.03 parts of niacinamide, 0.02 parts of polyglyceryl-4 oleate, 0.02 parts of isononyl isononanoate, 0.01 parts of cocoyl glucoside, 0.0063 parts of 3-o-ethyl ascorbic acid, 0.0063 parts of tocopheryl acetate, 0.009 parts of glycerin, 0.006 parts of butylene glycol, 0.001 parts of glycyrrhetinic acid, 0.004 parts of lecithin, 0.0006 parts of 1,2-hexanediol, and 0.0006 parts of caprylyl glycol.

[0168] In this embodiment, the encapsulated component 2 is stirred and mixed evenly at 45 degrees Celsius, and then added to the remaining phase D raw materials to participate in the preparation.

[0169] The components of the yellow wrapping are:

[0170] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0171] The components of the green wrapping are:

[0172] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0173] The raw materials of the yellow wrapped material and the green wrapped material are respectively stirred evenly and then added into the reaction.

[0174] Meanwhile, in this embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

[0175] Example 9

[0176] This embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0177] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0178] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.5 parts of aloe barbadensis leaf extract, 0.2 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0179] Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0180] Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0181] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0182] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0183] The preparation method of the whitening cream is as follows:

[0184] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0185] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0186] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0187] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0188] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0189] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0190] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0191] Wherein, in the D phase raw material, the wrapping component comprises: wrapping component 1 and wrapping component 2;

[0192] Wherein, the encapsulation component 1 comprises: 0.08 parts of water, 0.0255 parts of caprylic / capric triglyceride, 0.011 parts of steareth-21, 0.01 parts of phenethyl resorcinol, 0.01 parts of glyceryl ether-26, 0.0006 parts of ethoxydiglycol, 0.006 parts of polysorbate-800, 0.006 parts of laureth-23, 0.006 parts of coco-glucoside, 0.006 parts of coconut alcohol, 0.006 parts of PEG-40 stearate, 0.006 parts of butyloctanol salicylate, 0.006 parts of butylene glycol, 0.006 parts of steareth-20, 0.006 parts of sorbitan stearate, 0.0006 parts of diethylhexyl syringylidenemalonate, 0.0006 parts of butylated hydroxytoluene, and 0.0003 parts of disodium EDTA;

[0193] Package component 2 contains: 0.0876 parts of water, 0.015 parts of α-arbutin, 0.015 parts of niacinamide, 0.0075 parts of polyglyceryl-4 oleate, 0.0075 parts of isononyl isononanoate, 0.0045 parts of cocoyl glucoside, 0.003 parts of 3-o-ethyl ascorbic acid, 0.003 parts of tocopheryl acetate, 0.003 parts of glycerin, 0.003 parts of butylene glycol, 0.0003 parts of glycyrrhetinic acid, 0.0003 parts of lecithin, 0.00015 parts of 1,2-hexanediol, and 0.00015 parts of caprylyl glycol.

[0194] In this embodiment, the packaged component 1 and the packaged component 2 are stirred and mixed at 45 degrees Celsius respectively, and then added to the remaining phase D raw materials to participate in the preparation.

[0195] The components of the yellow wrapping are:

[0196] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0197] The components of the green wrapping are:

[0198] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0199] The raw materials of the yellow wrapped material and the green wrapped material are respectively stirred evenly and then added into the reaction.

[0200] Meanwhile, in this embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

[0201] Example 10

[0202] This embodiment provides a whitening cream, and its preparation raw materials include, by weight:

[0203] Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate;

[0204] Phase B raw materials: 3.92 parts of soybean (Glycine Soja) oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil;

[0205] Phase C materials: 0.5 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water;

[0206] Phase D materials: 0.45 parts of water, 0.15 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component;

[0207] E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol;

[0208] Raw materials for phase F: 2 parts of yellow wrapped material and 2 parts of green wrapped material.

[0209] The preparation method of the whitening cream is as follows:

[0210] S01 Preheat phase E and stir until it is completely dissolved without particles;

[0211] S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes;

[0212] S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed;

[0213] S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes;

[0214] Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, vacuum appropriately, and stir evenly;

[0215] S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly;

[0216] S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained.

[0217] Wherein, in the D phase raw material, the wrapping component comprises: wrapping component 1 and wrapping component 2;

[0218] Wherein, the encapsulation component 1 comprises: 0.08 parts of water, 0.0255 parts of caprylic / capric triglyceride, 0.011 parts of steareth-21, 0.01 parts of phenethyl resorcinol, 0.01 parts of glyceryl ether-26, 0.0006 parts of ethoxydiglycol, 0.006 parts of polysorbate-800, 0.006 parts of laureth-23, 0.006 parts of coco-glucoside, 0.006 parts of coconut alcohol, 0.006 parts of PEG-40 stearate, 0.006 parts of butyloctanol salicylate, 0.006 parts of butylene glycol, 0.006 parts of steareth-20, 0.006 parts of sorbitan stearate, 0.0006 parts of diethylhexyl syringylidenemalonate, 0.0006 parts of butylated hydroxytoluene, and 0.0003 parts of disodium EDTA;

[0219] Package component 2 contains: 0.0876 parts of water, 0.015 parts of α-arbutin, 0.015 parts of niacinamide, 0.0075 parts of polyglyceryl-4 oleate, 0.0075 parts of isononyl isononanoate, 0.0045 parts of cocoyl glucoside, 0.003 parts of 3-o-ethyl ascorbic acid, 0.003 parts of tocopheryl acetate, 0.003 parts of glycerin, 0.003 parts of butylene glycol, 0.0003 parts of glycyrrhetinic acid, 0.0003 parts of lecithin, 0.00015 parts of 1,2-hexanediol, and 0.00015 parts of caprylyl glycol.

[0220] In this embodiment, the packaged component 1 and the packaged component 2 are stirred and mixed at 45 degrees Celsius respectively, and then added to the remaining phase D raw materials to participate in the preparation.

[0221] The components of the yellow wrapping are:

[0222] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0223] The components of the green wrapping are:

[0224] 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerin, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylates / C10-30 alkyl acrylate crosspolymer.

[0225] The raw materials of the yellow wrapped material and the green wrapped material are respectively stirred evenly and then added into the reaction.

[0226] Meanwhile, in this embodiment, in the phase B, the soybean (GLYCINE SOJA) oil, aloe vera (ALOEBARBADENSIS) leaf extract, and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

[0227] Performance Testing

[0228] 1. Long-term storage test: The products prepared in Examples 1-10 were tested for more than 6 months, and the cosmetics were tested under condition 1: temperature (30±2)°C, relative humidity (66%±5%); condition 2: temperature (5±3)°C; condition 3: temperature (40±2)°C, relative humidity (75%±5%) to check the product properties.

[0229] 2. Harsh test: Test under harsh conditions of low temperature-high temperature in temperature cycle (-15~45℃), and check product properties after 2 cycles.

[0230] Table 1 Test results of performance test 1 and performance test 2

[0231]

[0232] Test 3: Tyrosinase inhibition rate test:

[0233] Levodopa was used as substrate (1 mg / mL) and kojic acid as positive control. The 96-well plate was used as carrier and the experiment was divided into 4 groups: reaction group, reaction control group, blank group, and blank control group. 25 μL samples of different concentrations were added to the reaction group and reaction control group, and 25 μL phosphate buffer was added to the blank group and blank control group. Subsequently, 25 μL tyrosinase was added to the reaction group and blank group, while the reaction control group and blank control group replaced tyrosinase with an equal amount of PBS. The mixture was mixed evenly, and 100 μL of levodopa solution was added to each well after incubation at 37°C for 5 minutes. After continuing to react in a 37°C incubator for 5 minutes, the absorbance (A) value was measured at a wavelength of 475 nm. The experimental data were all averaged after 3 repetitions. The tyrosinase inhibition rate was calculated according to the following formula, and the IC50 value was calculated using SPSS software.

[0234] Inhibition rate = 1-(A 反应 -A 反应对照 ) / (A 空白 -A 空白对照 )

[0235] Table 2 Test results of performance test 3 (n=3)

[0236] Example Group <![CDATA[IC 50 / (μmol·L -1 )]]> Example 1 0.28±0.14*** Example 2 0.87±0.11*** Example 3 0.82±0.23** Example 4 0.90±0.20** Example 5 1.02±0.11** Example 6 1.39±0.21** Example 7 8.56±0.35*** Example 8 9.42±0.68*** Example 9 1.23±0.16** Example 10 1.36±0.25** Kojic Acid 0.83±0.14

[0237] It can be seen from the above performance tests 1 to 3 that the physical properties and cosmetic efficacy of the product obtained in Example 1 are the best, so an allergy test is conducted on the product prepared in Example 1.

[0238] Performance Test 4: Human Skin Patch Test

[0239] 1. Test substances: the products of Example 1, Example 3, Example 4 and Example 6.

[0240] 2. Negative control: blank control.

[0241] 3. Subjects: A total of 30 people, including 6 males and 24 females, aged 22 to 60 years old, with an average age of 43.37±13.35 years old, who met the voluntary inclusion criteria.

[0242] 4. Patch test method: Select qualified patch test equipment and use the closed patch test method. Place about 0.020g~0.025g of the test substance in the patch tester and apply it to the back of the subject with low-allergenic tape. Remove the test substance after 24 hours and observe the skin reaction 0.5, 24, and 48 hours after removal. Record the results according to the skin reaction grading standards in the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0243] Table 3 Test results of performance test 4

[0244]

[0245] The results of human skin patch tests showed that no adverse reactions were observed among 30 people.

[0246] Test 5: Cosmetic whitening and freckle removal test method - Method 1: Ultraviolet-induced human skin darkening model whitening and freckle removal test method

[0247] Test product: the original cosmetic final product.

[0248] 2. Negative control: blank control of blackened area.

[0249] 3. Positive control: 7% ascorbic acid (vitamin C) product, prepared according to the formula in Appendix I of the "Technical Specifications for Safety of Cosmetics" (2015 edition) Announcement No. 17 of 2021 of the State Food and Drug Administration.

[0250] 4. Subjects: A total of 30 valid subjects completed the test, including 7 males and 23 females, aged 19 to 58 years old, with an average age of 40.27±12.88 years old, and met the voluntary inclusion and exclusion criteria of the subjects.

[0251] 5. Instruments and Equipment

[0252] 5.1 Daylight simulator: All performance indicators meet the requirements of the measurement specifications.

[0253] 5.2 Skin colorimeter: an instrument that can measure the L*a*b color space data developed by the International Commission on Illumination (CIE). 5.3 Skin melanin detector: an instrument that can detect skin MI value based on the principle of spectral absorption.

[0254] 6. Test method: Test in accordance with the specific requirements of the "Technical Specifications for Safety of Cosmetics" (2015 edition). The non-exposed area of ​​the subject's thigh was selected as the test site. The area of ​​each blackened test area should be no less than 0.5 cm and should be located in each coating area. Determine the MED of the test site of the subject. Use a solar simulator to irradiate once a day at the same irradiation point at a dose of 0.75 times the MED for 4 consecutive days. The 4 days after the end of irradiation are the skin blackening period, and no treatment is performed. On the 5th day after the end of irradiation, the skin of each test area is visually evaluated and instrumentally tested for skin color, and test areas with poor consistency are eliminated. Starting from the 5th day, the corresponding test substance is applied to each blackened test area according to the random table, and the test substance is applied continuously for at least 4 weeks. The skin color should be visually evaluated and instrumentally tested 1 week, 2 weeks, 3 weeks and 4 weeks after application, and recorded.

[0255] Table 4 Test results of performance test 5 (difference in visual skin color rating of each test area before and after product use (median))

[0256] 1 week 2 weeks 3 weeks 4 weeks Example 1 0 0* -1* -1.5* Positive Control 0 0* -1* -1.5* Negative control 0 0 0 0

[0257] Note: 1. Statistical analysis was performed using the rank sum test, compared with the negative control, *p<0.05;

[0258] 2. Difference = skin parameters after product use - skin parameters before product use.

[0259] Table 5 Test results of performance test 5 (visual skin color rating regression coefficient (slope k value) results)

[0260] Example 1 Positive Control Negative control -0.35* -0.35* -0.12

[0261] Note: 1. Statistical analysis was performed using the rank sum test, compared with the negative control, *p<0.05;

[0262] Table 6 Test results of performance test 5 (skin ITA° difference before and after product use (mean ± standard deviation))

[0263]

[0264]

[0265] Table 7 Test results of performance test 5 (difference in skin MI before and after product use (mean ± standard deviation))

[0266] 1 week 2 weeks 3 weeks 4 weeks Example 1 6.20±14.62 -8.08±17.32* -21.74±19.72* -34.98±21.84* Positive Control 4.17±12.78 -6.10±15.74* -19.09±19.11* -30.50±21.59* Negative control 5.41±9.61 2.99±10.00 0.22±10.82 -4.92±15.96

[0267] 1. After using the product of Example 1, the improvement degree of visual skin color grade of the test product group was significantly better than that of the negative control group at the follow-up time of 2 weeks, 3 weeks and 4 weeks after use (p<0.05), and the regression coefficient of visual skin color grade of the test product group was significantly improved compared with that of the negative control group (p<0.05);

[0268] 2. After using the test product, the improvement of the skin ITA° value of the test product group was significantly better than that of the negative control group at each follow-up time after use (p<0.05), and the regression coefficient of the skin ITA° value of the test product group was significantly improved compared with that of the negative control group (p<0.05);

[0269] 3. After using the test product, the improvement of the skin MI value of the test product group was significantly better than that of the negative control group at the follow-up time of 2 weeks, 3 weeks and 4 weeks after use (p<0.05), and the regression coefficient of the skin MI value of the test product group was significantly improved compared with that of the negative control group (p<0.05);

[0270] In summary, under the conditions of this experiment, the test product has the effect of removing spots and whitening the skin.

[0271] Performance Test 6 Toxicology Test Items

[0272] Toxicology test results:

[0273] 1. Results of multiple skin irritation tests: mildly irritating.

[0274] 2. Skin allergy test results: No skin allergy was found.

[0275] 3. Skin phototoxicity test results: No skin phototoxicity was observed.

[0276] Performance Test 6.1 Multiple Skin Irritation Test

[0277] 1. Test substance: Product of Example 1

[0278] The test sample is a milky white paste with yellow particles and green particles. The test sample is used as is.

[0279] 2. Experimental animals and breeding environment:

[0280] Animal information: Japanese big-eared white rabbit, ordinary grade

[0281] Number of animals: 4 females, 2.25-2.44 kg

[0282] Breeding unit: Beijing Changyang Xishan Breeding Farm (Experimental Animal Production License No.: SCXK(Beijing)2021-0008)

[0283] Animal quality certificate number: 110329230100040669

[0284] Experimental Animal Use License Number: SYXK(Tianjin)2023-0002

[0285] Breeding environment: temperature 20.8~25.2℃, relative humidity 40.0~69.9%

[0286] Feed type: rabbit maintenance feed

[0287] Feed source: SBC (Beijing) Biotechnology Co., Ltd. (SCXK (Beijing) 2019-0010) Feed certificate number: 1103242300106370

[0288] Test method:

[0289] 24 hours before the test, the hair on both sides of the rabbit's back spine was removed without damaging the skin. The hair removal range was about 3cm×3cm on the left and right. Take 0.5mL of the test substance and apply it to one side of the skin with a size of 2.5cm×2.5cm. Apply it carefully and slowly without losing the sample. The other side was used as a blank control. Once a day, apply continuously for 14 days. Starting from the second day, trim the hair before each application, remove the residual test substance with water, observe and record the presence of erythema and edema at the application site with the naked eye 1 hour later, and score it according to the "Skin Irritation Reaction Scoring" table in the "Safety Technical Specifications for Cosmetics" (2015 Edition). After the test, calculate the average score of the skin reaction of each animal, and grade the skin irritation intensity according to the "Skin Irritation Intensity Grading" table.

[0290] Table 8 Performance Test 6.1 Results of multiple skin irritation tests on rabbits by the test substance

[0291]

[0292] Performance test 6.2 Skin allergy test

[0293] 1. Test substance: Example 1

[0294] The test sample is a milky white paste with yellow particles and green particles. The test sample is used as is.

[0295] 2. Positive substances:

[0296] Name: 2,4-Dinitrochlorobenzene

[0297] Batch number: LSC0S73

[0298] Manufacturer: J&K

[0299] Solvent and preparation method: 95% ethanol; weigh 100mg (induction) / 100mg (excitation) of the positive substance in a 10mL small beaker, add about 4mL / 8mL of 95% ethanol and stir to dissolve in hot water at 45-50℃, then pour into a 10mL / 20mL volumetric flask, finally wash the remaining sample in the small beaker with distilled water, pour it into the volumetric flask, and add distilled water to the mark. The prepared test solution is milky white, and the volumetric flask is placed in hot water at about 50℃ to keep warm. Dosage: Induction dose: 10mg / mL, 0.2mL / sampling area; Excitation dose: 5mg / mL, 0.2mL / sampling area

[0300] 3. Experimental animals and breeding environment:

[0301] Animal information: Dunkin Hartley guinea pig, regular grade

[0302] Number of animals: 30 males, 291-333g

[0303] Breeding unit: Beijing Changyang Xishan Breeding Farm (Experimental Animal Production License No.: SCXK(Beijing)2021-0008)

[0304] Animal quality certificate number: 110329230100040673

[0305] Experimental Animal Use License Number: SYXK(Tianjin)2023-0002

[0306] Rearing environment: temperature 20.1~24.5℃, relative humidity 53.5~66.7%

[0307] Feed type: guinea pig growth and breeding feed

[0308] Feed source: SBC (Beijing) Biotechnology Co., Ltd. (SCXK (Beijing) 2019-0010) Feed certificate number: 1103242300106370

[0309] 4. Test methods

[0310] A total of 30 guinea pigs were used in the whole experiment. Two groups were set up: negative control group and test group. There were 10 animals in the negative control group and 20 animals in the test group.

[0311] About 24 hours before the test, the left side of the back of the experimental animals was depilated, and the depilation range was 4cm2 to 6cm2. On the 0th, 7th and 14th days, 0.2mL of the test substance was applied locally for 6 hours for induction. On the 28th day, 0.2mL of the test substance was applied to the right side of the back for 6 hours for local stimulation. The negative control group was only stimulated by the test substance. The positive control group was given 0.2mL of 10mg / mL and 5mg / mL of 2,4-dinitrochlorobenzene during induction and stimulation, respectively. The skin reaction was observed 24h and 48h after the removal of the closure piece, and the score was scored according to the "Allergy Test Skin Reaction Scoring Table" in the "Safety Technical Specifications for Cosmetics" (2015 Edition). When the skin reaction score is ≥2, the animal is judged to have a positive skin allergy, and the sensitization rate of all sampled animals is calculated, and the sensitization intensity is graded according to the "Sensitization Intensity Table" in the "Safety Technical Specifications for Cosmetics" (2015 Edition).

[0312] Table 9 Performance Test 6.2 Results of the Test Substance (or Positive Substance) on Guinea Pig Skin Allergy Test (BT Method)

[0313]

[0314] Note: ① The initial body weight and final body weight are expressed as mean ± SD.

[0315] ② In the skin reaction intensity column, fill in the ratio of the number of animals that react to the number of tested animals when the skin reaction score is 0, 1, 2, 3...

[0316] Positive control group test date: 2023.04.13 ~ 2023.05.13 Test group test date: 2023.07.26 ~ 2023.08.25

[0317] The sensitization rates of the negative control and the test group control were both 0%. The results of the skin allergy test of the test substance on guinea pigs were: no skin allergy was observed.

[0318] Performance test 6.3 Skin phototoxicity test

[0319] 1. Test substance: Inpocet Whitening and Anti-Freckle Cream

[0320] The test sample is a milky white paste with yellow particles and green particles. The test sample is used as is.

[0321] 2. Positive substances:

[0322] Name: 8-Methoxypsoralea corylifolia

[0323] Batch number: P20A10M86434 Manufacturer: Shanghai Yuanye Biotechnology Co., Ltd.

[0324] Solvent and preparation method: 95% ethanol, use 95% ethanol to prepare 0.1% solution

[0325] Dosage: 0.1%, 0.2mL / sampling area

[0326] 3. Experimental animals and breeding environment:

[0327] Animal information: Dunkin Hartley guinea pig, regular grade

[0328] Number of animals: 3 females, 278-286g; 3 males, 279-293g

[0329] Breeding unit: Tianjin Yuda Experimental Animal Breeding Co., Ltd. (Experimental Animal Production License No.: SCXK(Tianjin)2021-0001)

[0330] Animal quality certificate number: 120906230100058635

[0331] Experimental Animal Use License Number: SYXK(Tianjin)2023-0002

[0332] Rearing environment: temperature 21.6~23.6℃, ​​relative humidity 40.2~67.0%

[0333] Feed type: guinea pig growth and breeding feed

[0334] Feed source: SBC (Beijing) Biotechnology Co., Ltd. (SCXK (Beijing) 2019-0010) Feed certificate number: 1103242300106370

[0335] 4. Instrument: manufacturer and model of light source

[0336] Name: Skin phototoxicity test instrument

[0337] Model: Hope-MED8130B

[0338] Manufacturer: Tianjin Development Zone Hepu Industry and Trade Co., Ltd.

[0339] Test methods

[0340] 18-24 hours before the test, according to the "Technical Specifications for Safety of Cosmetics" (2015 Edition) Chapter 6 7, Skin Phototoxicity Test Figure 1The test area shown is to remove the hair on both sides of the spine of the guinea pig's back, and each hair removal area is 2cm×2cm. The skin should not be damaged during the hair removal process, and the skin of the hair removal area should be kept intact. The animal is fixed on the corresponding fixing frame, and 0.2mL of the test substance is applied to the hair removal area 1 and 2 as shown in Table 1. After 30 minutes, the left side (hair removal area 1 and 3) is covered with aluminum foil, fixed with tape, and placed in the skin phototoxicity instrument, and the irradiation dose is set to 10000mJ / cm2 for UVA irradiation. Observe the skin reaction at 1h, 24h, 48h, and 72h after the end of irradiation, and score according to Chapter 6.7 "Table 2 Skin Irritation Reaction Scoring Table" of the "Safety Technical Specifications for Cosmetics" (2015 Edition). If there is no skin reaction in the non-irradiated area after the test substance is applied alone, and the number of animals with a skin reaction score of 2 or more in the irradiated area after the test substance is applied is 1 or more, the test substance is judged to be phototoxic, otherwise it is non-phototoxic.

[0341] Table 10 Performance Test 6.3 Results of Phototoxicity Test of Positive Control on Guinea Pig Skin

[0342]

[0343] Table 11 Performance Test 6.3 Results of the Phototoxicity Test of the Test Substance on Guinea Pig Skin

[0344]

[0345] The results of the phototoxicity test of the test substance on guinea pig skin: no skin phototoxicity was observed.

[0346] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A whitening cream, characterized in that: In parts by mass, the raw materials for its preparation include: Phase A materials: 61.14 parts of water, 5 parts of glycerin, 2.1 parts of butylene glycol, 3.5 parts of niacinamide, 0.5 parts of acetyl glucosamine, 0.5 parts of panthenol, and 0.02 parts of sodium hyaluronate; Phase B raw materials: 3.92 parts of soybean oil, 0.04 parts of aloe barbadensis leaf extract, 0.04 parts of vitamin E, 3 parts of cetyl ethylhexanoate, 4.2 parts of cetearyl alcohol, 0.5 parts of cetearyl glucoside, 2.036 parts of polydimethylsiloxane, 2 parts of isohexadecane, 0.052 parts of aluminum hydroxide, 0.5 parts of PEG-100 stearate, 0.5 parts of glyceryl stearate, 0.4 parts of tocopheryl acetate, 0.2 parts of jojoba seed oil; Phase C materials: 0.2 parts of polyacrylamide, 0.1 parts of C13-14 isoparaffin, 0.028 parts of laureth-7, and 0.173 parts of water; Phase D materials: 0.45 parts of water, 0.05 parts of soluble collagen cross-linked polymer, 0.004 parts of 1,2-hexanediol, 0.002 parts of p-hydroxyacetophenone, and 0.35 parts of encapsulation component; E phase raw materials: 1.9 parts of butanediol, 0.5 parts of p-hydroxyacetophenone, and 0.5 parts of 1,2-hexanediol; Raw materials for phase F: 2 parts of yellow wrapped material, 2 parts of green wrapped material; The preparation method of the whitening cream is as follows: S01 Preheat phase E and stir until it is completely dissolved without particles; S02: Put the phase A material into the water phase pot and heat it to 80-85°C; start stirring and homogenizing for 3-5 minutes; S03 put the B phase material into the oil phase pot, heat it to 80-85℃, and stir it thoroughly until all phases are evenly dispersed; S04: Pump phase B from the oil phase pot to the phase A emulsification pot; start stirring and homogenizing, homogenize for 5-8 minutes and stir evenly; evacuate, keep warm and emulsify for 30 minutes; Cool S05 to 70-65℃, add phase C, start stirring, homogenize for 3-5 minutes, stir evenly, evacuate appropriately, and stir evenly; S06 cools down to 60-65℃, puts the materials of phase D and phase E into the emulsifying pot in turn, starts stirring, vacuumizes, and stirs evenly; S07 cools down to below 40℃, puts the F phase particles into the emulsifying pot, stirs at low speed until evenly mixed; then the mixture is obtained; Wherein, in the D phase raw material, the wrapping component comprises: wrapping component 1 and wrapping component 2; Wherein, the encapsulation component 1 comprises: 0.08 parts of water, 0.0255 parts of caprylic / capric triglyceride, 0.011 parts of steareth-21, 0.01 parts of phenethyl resorcinol, 0.01 parts of glyceryl ether-26, 0.0006 parts of ethoxydiglycol, 0.006 parts of polysorbate-800, 0.006 parts of laureth-23, 0.006 parts of coco-glucoside, 0.006 parts of coconut alcohol, 0.006 parts of PEG-40 stearate, 0.006 parts of butyloctanol salicylate, 0.006 parts of butylene glycol, 0.006 parts of steareth-20, 0.006 parts of sorbitan stearate, 0.0006 parts of diethylhexyl syringylidenemalonate, 0.0006 parts of butylated hydroxytoluene, and 0.0003 parts of disodium EDTA; Package component 2 contains: 0.0876 parts of water, 0.015 parts of α-arbutin, 0.015 parts of niacinamide, 0.0075 parts of polyglyceryl-4 oleate, 0.0075 parts of isononyl isononanoate, 0.0045 parts of cocoyl glucoside, 0.003 parts of 3-o-ethyl ascorbic acid, 0.003 parts of tocopheryl acetate, 0.003 parts of glycerin, 0.003 parts of butylene glycol, 0.0003 parts of glycyrrhetinic acid, 0.0003 parts of lecithin, 0.00015 parts of 1,2-hexanediol, and 0.00015 parts of caprylyl glycol; The encapsulated component 1 and the encapsulated component 2 are stirred and mixed at 45 degrees Celsius, and then added to the remaining phase D raw materials to participate in the preparation; The components of the yellow coating are: 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerol, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of β-carotene, and 0.0016 parts of acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer; The components of the green wrapping are: 1.0738 parts of water, 0.48 parts of caprylic / capric triglyceride, 0.32 parts of squalane, 0.06 parts of butylene glycol, 0.04 parts of glycerol, 0.006 parts of 1,2-hexanediol, 0.012 parts of caprylyl glycol, 0.004 parts of sodium alginate, 0.0026 parts of copper chlorophyll, and 0.0016 parts of acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer; The raw materials of the yellow and green wrapped materials are stirred evenly respectively and then added to the reaction; In the phase B, the wild soybean oil, aloe vera leaf extract and vitamin E are pre-mixed and then added to the remaining phase B materials to participate in the reaction.

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