Gastrodin compound composition for treating dizziness and preparation method thereof

Abstract

The application discloses a Gastrodia elata compound composition for treating dizziness, which is prepared from Gastrodia elata 30-50 parts, ginseng 20-30 parts, astragalus 15-25 parts, medlar 18-22 parts, yam 20-30 parts, concha margaritifera 15-25 parts, mulberry leaf 20-30 parts and the like in parts by weight, and a preparation method thereof is disclosed. The Gastrodia elata compound composition is used for treating dizziness caused by liver yang hyperactivity syndrome due to phlegm turbidity accumulation by tonifying qi and blood, invigorating spleen and stomach, calming liver and suppressing yang, clearing away heat and extinguishing wind, drying dampness and eliminating phlegm, removing blood stasis and generating new blood, promoting blood circulation to remove meridian obstruction, invigorating spleen and transportation, and descending stomach qi.

Description

Technical Field

[0001] This invention relates to a compound composition of Gastrodia elata for treating vertigo and its preparation method, belonging to the field of traditional Chinese medicine technology. Background Technology

[0002] Vertigo is a subjective sensory disturbance in which the patient feels themselves or the environment spinning or swaying. It can be classified as rotational or non-rotational, and also as spontaneous or induced. Rotational vertigo includes the sensation of spinning or rolling, while non-rotational vertigo includes sensations of swaying, tilting, floating, or sliding. Common causes of vertigo include medical conditions (such as peripheral vestibular vertigo and central vestibular vertigo), medications, environmental factors, and lifestyle. Certain groups, such as the elderly or those with diseases of the visual system, vestibular organs, or proprioceptive system, are more prone to vertigo.

[0003] Traditional Chinese medicine (TCM) considers vertigo to be a general term for dizziness and lightheadedness. Vertigo is characterized by blurred vision, unclear or blackouts, while lightheadedness is characterized by a spinning sensation or a feeling of the world spinning around, making it impossible to stand. Because these two symptoms often occur simultaneously, it is called vertigo. Mild cases can be relieved by closing the eyes, while severe cases feel like being in a moving vehicle or boat, with a spinning sensation that prevents standing, and may be accompanied by nausea, vomiting, and paleness. TCM treatment is characterized by syndrome differentiation and treatment based on syndrome differentiation; therefore, the treatment of vertigo also requires syndrome differentiation and treatment, with different treatment methods for different syndrome types. CN117679476A discloses a TCM compound composition for treating vertigo caused by hypertension and its preparation method. The raw materials of this traditional Chinese medicine compound composition for treating hypertension-induced dizziness, by weight, include: 30-120 parts calcined magnetite, 15-60 parts Eucommia ulmoides, 20-180 parts Gastrodia elata, 15-120 parts Apocynum venetum leaf, 10-40 parts Achyranthes bidentata, 8-30 parts Pinellia ternata, 15-120 parts stir-fried Atractylodes macrocephala, 10-120 parts Alisma plantago-aquatica, 30-120 parts Pueraria lobata, 10-60 parts Zea mays silk, and 10-40 parts Stevia rebaudiana. This traditional Chinese medicine compound composition has a good antihypertensive effect on patients with hypertension-induced dizziness and can significantly improve clinical symptoms such as dizziness, lightheadedness, blurred vision, tinnitus, bitter taste in the mouth, nausea, vomiting, numbness of limbs, and insomnia. It is effective in treating hypertension-induced dizziness (wind-phlegm disturbance syndrome) and is safe and reliable. CN116459315A discloses a traditional Chinese medicine composition for treating dizziness caused by cervical spondylosis and its uses. The composition of this invention is made from the following raw materials in parts by weight: Gastrodia elata 10-20 parts, Achyranthes bidentata 10-20 parts, Ligusticum chuanxiong 10-30 parts, Pheretima aspergillum 10-20 parts, Musk 10-15 parts, Notopterygium incisum 20-30 parts, Polygala tenuifolia 10-20 parts, Borneol 20-25 parts, Acorus tatarinowii 20-40 parts, and Gardenia jasminoides 10-15 parts. This composition can be used as a filling ingredient in a medicinal pillow to make a traditional Chinese medicine pillow. The traditional Chinese medicine composition of this invention and the medicinal pillow made from it have a good therapeutic effect on dizziness caused by cervical spondylosis and have good application prospects. However, the above composition targets dizziness caused by disease, without analyzing the causes of dizziness from the perspective of traditional Chinese medicine treatment principles, thus its applicability is narrow and not conducive to the treatment of dizziness. Summary of the Invention

[0004] The purpose of this invention is to provide a Gastrodia elata compound composition for treating vertigo and its preparation method. Based on the principles of traditional Chinese medicine, this invention is effective in treating vertigo caused by liver yang hyperactivity due to phlegm accumulation, demonstrating significant efficacy and good clinical results.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: a compound composition of Gastrodia elata for treating dizziness, wherein the compound composition of Gastrodia elata is prepared from the following parts by weight: 30-50 parts of Gastrodia elata, 20-30 parts of ginseng, 15-25 parts of Astragalus membranaceus, 18-22 parts of Lycium barbarum, 20-30 parts of Dioscorea opposita, 15-25 parts of Haliotis diversicolor, 20-30 parts of Morus alba leaf, 15-25 parts of pearl powder, 18-22 parts of Citrus reticulata peel, 20-30 parts of Pinellia ternata, 10-20 parts of Arisaema heterophyllum, 15-25 parts of Atractylodes lancea, 20-30 parts of Leonurus japonicus, 18-22 parts of Paeonia lactiflora, 20-30 parts of Paeonia suffruticosa bark, 18-22 parts of Ligusticum chuanxiong, 25-35 parts of Crataegus pinnatifida, 20-30 parts of Raphanus sativus seed, 18-22 parts of Citrus aurantium, and 20-30 parts of Perilla frutescens seed.

[0006] The Gastrodia elata compound composition for treating vertigo is prepared from the following ingredients in parts by weight: 40 parts Gastrodia elata, 25 parts ginseng, 20 parts Astragalus membranaceus, 20 parts Lycium barbarum, 25 parts Dioscorea opposita, 20 parts Haliotis diversicolor, 25 parts Morus alba leaf, 20 parts pearl powder, 20 parts Citrus reticulata peel, 25 parts Pinellia ternata, 15 parts Arisaema heterophyllum, 20 parts Atractylodes lancea, 25 parts Leonurus japonicus, 20 parts Paeonia lactiflora, 25 parts Paeonia suffruticosa bark, 20 parts Ligusticum chuanxiong, 30 parts Crataegus pinnatifida, 25 parts Raphanus sativus seed, 20 parts Citrus aurantium, and 25 parts Perilla frutescens seed.

[0007] The Gastrodia elata compound composition for treating vertigo is prepared from the following ingredients in parts by weight: 30 parts Gastrodia elata, 20 parts ginseng, 25 parts Astragalus membranaceus, 18 parts Lycium barbarum, 30 parts Dioscorea opposita, 25 parts Haliotis diversicolor, 20 parts Morus alba leaf, 25 parts pearl powder, 18 parts Citrus reticulata peel, 30 parts Pinellia ternata, 10 parts Arisaema heterophyllum, 25 parts Atractylodes lancea, 20 parts Leonurus japonicus, 22 parts Paeonia lactiflora, 20 parts Paeonia suffruticosa, 22 parts Ligusticum chuanxiong, 25 parts Crataegus pinnatifida, 30 parts Raphanus sativus seed, 18 parts Citrus aurantium, and 30 parts Perilla frutescens seed.

[0008] The Gastrodia elata compound composition for treating vertigo is prepared from the following ingredients in parts by weight: 50 parts Gastrodia elata, 30 parts ginseng, 15 parts Astragalus membranaceus, 22 parts Lycium barbarum, 20 parts Dioscorea opposita, 15 parts Haliotis diversicolor, 30 parts Morus alba, 15 parts Margarita, 22 parts Citrus reticulata peel, 20 parts Pinellia ternata, 20 parts Arisaema heterophyllum, 15 parts Atractylodes lancea, 30 parts Leonurus japonicus, 18 parts Paeonia lactiflora, 30 parts Paeonia suffruticosa, 18 parts Ligusticum chuanxiong, 35 parts Crataegus pinnatifida, 20 parts Raphanus sativus, 22 parts Citrus aurantium, and 30 parts Perilla frutescens.

[0009] The preparation method of the Gastrodia elata compound composition for treating vertigo includes the following steps:

[0010] (1) Take abalone shell and mother-of-pearl, add ten times the weight of water and decoct for 1-3 hours. Add other Chinese medicinal materials and make up the water volume to ten times the weight of all medicinal materials. Decoction twice, 2 hours each time. Combine the decoctions, filter, concentrate the filtrate to an extract with a relative density of 1.10 at 80℃, and set aside.

[0011] (2) Add ethanol to make the alcohol content reach 50%-75%, stir continuously, let stand for 12-48 hours, filter, recover ethanol from the filtrate under reduced pressure to clean and concentrate to an extract with a relative density of 1.05-1.10 at 50℃. After drying the extract, pulverize it into dry extract powder for later use.

[0012] (3) Take the dry powder, crush it, add excipients, and make a pharmaceutical preparation.

[0013] The Gastrodia elata compound composition for treating vertigo is prepared in one of the following dosage forms: tablets, capsules, or granules.

[0014] The application of the Gastrodia elata compound composition for treating vertigo in the preparation of drugs for treating vertigo.

[0015] The application of the Gastrodia elata compound composition for treating vertigo in the preparation of drugs for treating vertigo, wherein the vertigo syndrome belongs to the syndrome of liver yang hyperactivity caused by phlegm turbidity.

[0016] Dizziness is recurrent and has a long course, often presenting as a deficiency in the root and an excess in the branch, with frequent transformations between the two. In the early stages, when the course of the disease is short, it often manifests as an excess pattern, such as phlegm obstruction, blood stasis, or liver yang hyperactivity due to yin-yang imbalance. If it persists, it can transform into a deficiency pattern of qi and blood deficiency and kidney essence insufficiency. Dizziness caused by qi and blood deficiency and kidney essence insufficiency can also recur, leading to poor circulation of qi, blood, and body fluids, and the internal generation of phlegm and blood stasis, thus transforming into a mixed deficiency-excess pattern. In cases of phlegm obstruction, the phlegm can transform into fire, stirring up liver yang, which can then transform into liver yang hyperactivity or wind-phlegm disturbance. The internal accumulation of phlegm can also obstruct the circulation of qi and blood, eventually leading to phlegm and blood stasis. The most common is liver yang hyperactivity caused by internal accumulation of phlegm.

[0017] Based on the principle of treating both the symptoms and the root cause, the liver yang hyperactivity syndrome caused by phlegm and turbidity often occurs in elderly and weak patients. They often have insufficient qi and blood, and the brain is not properly nourished. The clinical symptoms are: dizziness, which is aggravated by movement and triggered by fatigue, shortness of breath and low voice, pale complexion, tinnitus, headache, irritability, insomnia and dreaminess, slippery or wiry slippery pulse, or accompanied by soreness and weakness of the waist and knees, forgetfulness, dizziness and fainting, nausea, headache like pulling, numbness and tremors of the limbs, slurred speech, and unsteady gait. Due to insufficient Qi and blood, fatigue, lethargy, pale complexion, spleen and lung Qi deficiency, shortness of breath, weak voice, and malnourishment of the heart and spirit, palpitations and insomnia, the first step is to replenish Qi and blood and strengthen the spleen and stomach. Additionally, liver Yang rising upwards, causing dizziness, tinnitus, and a wiry pulse, requires calming the liver, suppressing Yang, clearing heat, and extinguishing wind. Simultaneously, phlegm obstructs the middle Jiao, clouding the sensory orifices, causing dizziness. Phlegm is a form of dampness, heavy and turbid, obstructing clear Yang, hence fatigue and a heavy head. Phlegm obstruction also hinders Qi circulation, causing chest tightness. If it is due to Yang deficiency failing to transform water, resulting in internal retention of cold phlegm that rises upwards and attacks the heart, then epigastric fullness, palpitations, and anxiety will also occur, requiring the drying of dampness and elimination of phlegm. Furthermore, blood stasis obstructs the collaterals, preventing the normal flow of Qi and blood, and depriving the brain of nourishment, hence the frequent dizziness, requiring the removal of blood stasis, promotion of new blood, and unblocking of the collaterals. Stomach qi rises in reverse, hence the frequent expectoration of phlegm; spleen yang is obstructed by phlegm and dampness and thus does not function well, hence the reduced appetite and excessive sleep. These are all signs of internal accumulation of phlegm and dampness, and it is necessary to strengthen the spleen to aid digestion and regulate stomach qi.

[0018] This invention uses ginseng, astragalus, wolfberry, and yam to replenish qi and blood, and strengthen the spleen and stomach; gastrodia, abalone shell, mulberry leaf, and mother-of-pearl to calm the liver, subdue yang, clear heat, and extinguish wind, serving as the principal herbs; tangerine peel, pinellia, arisaema, and atractylodes to dry dampness and eliminate phlegm, serving as the assistant herbs; motherwort, red peony root, peony bark, and chuanxiong to remove blood stasis, promote new blood circulation, and unblock collaterals, serving as the adjuvant herbs; and hawthorn, radish seed, immature bitter orange, and perilla seed to strengthen the spleen, aid digestion, and regulate stomach qi, serving as the guiding herbs. The entire formula contains... Ginseng, astragalus, wolfberry, yam, gastrodia, abalone shell, mulberry leaf, mother-of-pearl, tangerine peel, pinellia, arisaema, atractylodes, motherwort, red peony root, peony bark, chuanxiong rhizome, hawthorn, radish seed, immature bitter orange, and perilla seed work together to treat dizziness caused by liver yang hyperactivity due to internal phlegm accumulation by replenishing qi and blood, strengthening the spleen and stomach, calming the liver and suppressing yang, clearing heat and extinguishing wind, drying dampness and eliminating phlegm, removing blood stasis and promoting new blood production, activating blood circulation and unblocking collaterals, strengthening the spleen and aiding digestion, and regulating stomach qi. Detailed Implementation

[0019] The present invention will be further described below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, it should be understood that after reading the description of this invention, those skilled in the art can make various alterations or modifications to the invention, but these equivalent forms also fall within the scope defined by the appended claims.

[0020] Example 1: The following ingredients were used in the preparation of Gastrodia elata 40g, Ginseng 25g, Astragalus membranaceus 20g, Lycium barbarum 20g, Dioscorea opposita 25g, Haliotis diversicolor 20g, Morus alba leaf 25g, Mother-of-pearl 20g, Tangerine peel 20g, Pinellia ternata 25g, Arisaema heterophyllum 15g, Atractylodes lancea 20g, Leonurus japonicus 25g, Paeonia lactiflora 20g, Paeonia suffruticosa 25g, Ligusticum chuanxiong 20g, Crataegus pinnatifida 30g, Raphanus sativus seed 25g, Citrus aurantium 20g, and Perilla frutescens seed 25g:

[0021] (1) Take abalone shell and mother-of-pearl, add ten times the weight of water and decoct for 2 hours. Add other Chinese medicinal materials and make up the water volume to ten times the weight of all medicinal materials. Decoction twice, 2 hours each time. Combine the decoctions, filter, concentrate the filtrate to an extract with a relative density of 1.10 at 80℃, and set aside.

[0022] (2) Add ethanol to make the alcohol content reach 65%, stir continuously, let stand for 36 hours, filter, recover ethanol from the filtrate under reduced pressure until clean, and concentrate to an extract with a relative density of 1.08 at 50°C. After drying the extract, pulverize it into dry extract powder for later use.

[0023] (3) Take the dry powder, crush it, add dextrin, and make it into granules.

[0024] Example 2: The following ingredients were used in the preparation of Gastrodia elata 40g, Ginseng 25g, Astragalus membranaceus 20g, Lycium barbarum 20g, Dioscorea opposita 25g, Haliotis diversicolor 20g, Morus alba leaf 25g, Mother-of-pearl 20g, Tangerine peel 20g, Pinellia ternata 25g, Arisaema heterophyllum 15g, Atractylodes lancea 20g, Leonurus japonicus 25g, Paeonia lactiflora 20g, Paeonia suffruticosa 25g, Ligusticum chuanxiong 20g, Crataegus pinnatifida 30g, Raphanus sativus seed 25g, Citrus aurantium 20g, and Perilla frutescens seed 25g:

[0025] (1) Take abalone shell and mother-of-pearl, add ten times the weight of water and decoct for 1 hour. Add other Chinese medicinal materials and make up the water volume to ten times the weight of all medicinal materials. Decoction twice, 2 hours each time. Combine the decoctions, filter, concentrate the filtrate to an extract with a relative density of 1.10 at 80℃, and set aside.

[0026] (2) Add ethanol to make the alcohol content reach 75%, stir continuously, let stand for 12 hours, filter, recover ethanol from the filtrate under reduced pressure until clean, and concentrate to an extract with a relative density of 1.10 at 50°C. After drying the extract, pulverize it into dry extract powder for later use.

[0027] (3) Take the dry powder, crush it, add starch, and make tablets.

[0028] Example 3: The following ingredients were used in the preparation of Gastrodia elata 40g, Ginseng 25g, Astragalus membranaceus 20g, Lycium barbarum 20g, Dioscorea opposita 25g, Haliotis diversicolor 20g, Morus alba leaf 25g, Mother-of-pearl 20g, Tangerine peel 20g, Pinellia ternata 25g, Arisaema heterophyllum 15g, Atractylodes lancea 20g, Leonurus japonicus 25g, Paeonia lactiflora 20g, Paeonia suffruticosa 25g, Ligusticum chuanxiong 20g, Crataegus pinnatifida 30g, Raphanus sativus seed 25g, Citrus aurantium 20g, and Perilla frutescens seed 25g: The preparation method includes the following steps:

[0029] (1) Take abalone shell and mother-of-pearl, add ten times the weight of water and decoct for 3 hours. Add other Chinese medicinal materials and make up the water volume to ten times the weight of all medicinal materials. Decoction twice, 2 hours each time. Combine the decoctions, filter, concentrate the filtrate to an extract with a relative density of 1.10 at 80℃, and set aside.

[0030] (2) Add ethanol to make the alcohol content reach 50%, stir continuously, let stand for 48 hours, filter, recover ethanol from the filtrate under reduced pressure until clean, and concentrate to an extract with a relative density of 1.05 at 50°C. After drying the extract, pulverize it into dry extract powder for later use.

[0031] (3) Take the dry powder, pulverize it, add microcrystalline cellulose, and make capsules.

[0032] Example 4: Experiment on chloroform-induced dizziness in guinea pigs according to the present invention

[0033] Healthy guinea pigs, half male and half female, weighing 250-300g, were randomly divided into 5 groups: a control group, groups 1-3 of this invention (10g / kg), and a positive control group receiving difenidol hydrochloride tablets (12.5mg / kg). Each group contained 10 animals. All groups received the corresponding drug via intragastric gavage (ig), at a volume of 10mL / kg, once daily for a total of 14 doses. Thirty minutes after the last administration, 15μL of chloroform was instilled into the right ear of each guinea pig. The latency and duration of nystagmus were observed, with a cutoff of 60 minutes. The results are shown in Table 1.

[0034] Table 1. Effects of this invention on the latency and duration of chloroform-induced nystagmus in guinea pigs (x±s, n=10)

[0035]

[0036] Compared with the control group: * P < 0.05 ** P < 0.01

[0037] As shown in Table 1, all three groups of the present invention can significantly prolong the latency of nystagmus in guinea pigs and shorten the duration of nystagmus. Compared with the control group, the differences are significant (P<0.05, 0.01), and the effects are close to those of the positive control drug.

[0038] Example 5: Clinical efficacy evaluation of the present invention in treating dizziness caused by phlegm-dampness accumulation and liver yang hyperactivity.

[0039] 1. Case source: 120 patients with vertigo caused by liver yang hyperactivity due to phlegm turbidity who visited the clinic between January 2022 and January 2023 were selected.

[0040] 2. Diagnostic Criteria: ① Vertigo is characterized by episodic sensations of spinning, swaying, or instability, often triggered by changes in head or body position. ② Vertigo is accompanied by other symptoms of transient brainstem ischemia, such as eye symptoms, inner ear pain, limb numbness or weakness, sudden falls, or syncope. ③ Mild signs of brainstem damage are present, such as decreased or absent corneal or pharyngeal reflexes, accommodation and assistive reflex disorders, spontaneous or vertebral artery compression induced by neck rotation, and positive pathological reflexes. ④ Blood pressure, hemoglobin, red blood cell count, electrocardiogram, audiometry, brainstem evoked potentials, cervical spine X-ray, and transcranial Doppler ultrasound can aid in diagnosis; CT scans are recommended if available. ⑤ Vertigo caused by tumors, external trauma, brain injury, blood disorders, cerebral infarction, or cerebral hemorrhage is excluded.

[0041] 3. Case selection: (1) Meeting the diagnostic criteria of Western medicine for vertigo; (2) Meeting the diagnostic criteria of traditional Chinese medicine for vertigo caused by phlegm and turbidity accumulation leading to liver yang hyperactivity syndrome; Specifically: Clinical symptoms include: vertigo, which worsens with movement and is triggered by fatigue, shortness of breath and low voice, pale complexion, tinnitus, headache, irritability, insomnia and dreaminess, slippery or wiry pulse, or accompanied by soreness and weakness of the waist and knees, forgetfulness, dizziness and feeling like falling, nausea, headache like pulling, numbness and tremors of the limbs, speech difficulties, and unsteady gait.

[0042] 4. Efficacy Evaluation Criteria: Cured: Dizziness and other symptoms disappear; efficacy index ≥ 90%. Significantly Effective: Dizziness and other symptoms are significantly reduced; slight lightheadedness or vertigo is present but without a sensation of spinning or swaying of oneself or surroundings; normal life and work are possible. Efficacy index ≥ 70%, with simultaneous effects < 90%. Effective: Dizziness or vertigo is reduced, accompanied only by a slight sensation of spinning or swaying of oneself or surroundings; although work can be continued, life and work are affected. Efficacy index ≥ 30%, with simultaneous effects < 70%. Ineffective: No improvement or worsening of lightheadedness and vertigo; efficacy index < 30%.

[0043] 5. Treatment Process: The granule product prepared in Example 1 of this invention (daily prescription dosage: Gastrodia elata 40g, Ginseng 25g, Astragalus membranaceus 20g, Lycium barbarum 20g, Dioscorea opposita 25g, Haliotis diversicolor 20g, Morus alba leaf 25g, Pearl powder 20g, Tangerine peel 20g, Pinellia ternata 25g, Arisaema heterophyllum 15g, Atractylodes lancea 20g, Leonurus japonicus 25g, Paeonia lactiflora 20g, Paeonia suffruticosa 25g, Ligusticum chuanxiong 20g, Crataegus pinnatifida 30g, Raphanus sativus seed 25g, Citrus aurantium 20g, Perilla frutescens seed 25g) was used 3 times a day, 2 packets each time, for 1 month; the control group took Jiuzhitang Gastrodia elata and Uncaria rhynchophylla granules (sugar-free) with the approval number Z51021084, produced by Chengdu Jiuzhitang Jinding Pharmaceutical Co., Ltd., one packet (10g) each time, 3 times a day, for 1 month.

[0044] 6. The treatment results are shown in Table 2.

[0045] Table 2 Comparison of clinical efficacy between the two groups

[0046] Group get well Effective efficient invalid Overall effectiveness (%) control group 15 14 14 17 71.7 Example 1 Group 28 13 15 4 93.3

[0047] 7. Conclusion: Comparing the clinical efficacy of the two groups, the effective rate of the first group after treatment was 93.3%, which was significantly higher than the effective rate of 71.7% in the control group. This indicates that the present invention has a better clinical effect on dizziness caused by phlegm and turbidity accumulation and liver yang hyperactivity.

[0048] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A compound composition of Gastrodia elata for treating vertigo, characterized in that: The Gastrodia elata compound composition is prepared from the following ingredients in parts by weight: 30-50 parts Gastrodia elata, 20-30 parts Ginseng, 15-25 parts Astragalus membranaceus, 18-22 parts Lycium barbarum, 20-30 parts Dioscorea opposita, 15-25 parts Haliotis diversicolor, 20-30 parts Morus alba leaf, 15-25 parts Margarita, 18-22 parts Citrus reticulata peel, 20-30 parts Pinellia ternata, 10-20 parts Arisaema heterophyllum, 15-25 parts Atractylodes lancea, 20-30 parts Leonurus japonicus, 18-22 parts Paeonia lactiflora, 20-30 parts Paeonia suffruticosa bark, 18-22 parts Ligusticum chuanxiong, 25-35 parts Crataegus pinnatifida, 20-30 parts Raphanus sativus seed, 18-22 parts Citrus aurantium, and 20-30 parts Perilla frutescens seed.

2. The Gastrodia elata compound composition for treating vertigo as described in claim 1, characterized in that: The Gastrodia elata compound composition is prepared from the following ingredients in parts by weight: 40 parts Gastrodia elata, 25 parts ginseng, 20 parts Astragalus membranaceus, 20 parts Lycium barbarum, 25 parts Dioscorea opposita, 20 parts Haliotis diversicolor, 25 parts Morus alba leaf, 20 parts pearl powder, 20 parts Citrus reticulata peel, 25 parts Pinellia ternata, 15 parts Arisaema heterophyllum, 20 parts Atractylodes lancea, 25 parts Leonurus japonicus, 20 parts Paeonia lactiflora, 25 parts Paeonia suffruticosa bark, 20 parts Ligusticum chuanxiong, 30 parts Crataegus pinnatifida, 25 parts Raphanus sativus seed, 20 parts Citrus aurantium, and 25 parts Perilla frutescens seed.

3. The Gastrodia elata compound composition for treating vertigo as described in claim 1, characterized in that: The Gastrodia elata compound composition is prepared from the following ingredients in parts by weight: 30 parts Gastrodia elata, 20 parts ginseng, 25 parts Astragalus membranaceus, 18 parts Lycium barbarum, 30 parts Dioscorea opposita, 25 parts Haliotis diversicolor, 20 parts Morus alba leaf, 25 parts pearl powder, 18 parts Citrus reticulata peel, 30 parts Pinellia ternata, 10 parts Arisaema heterophyllum, 25 parts Atractylodes lancea, 20 parts Leonurus japonicus, 22 parts Paeonia lactiflora, 20 parts Paeonia suffruticosa, 22 parts Ligusticum chuanxiong, 25 parts Crataegus pinnatifida, 30 parts Raphanus sativus seed, 18 parts Citrus aurantium, and 30 parts Perilla frutescens seed.

4. The Gastrodia elata compound composition for treating vertigo as described in claim 1, characterized in that: The preparation method includes the following steps: (1) Take abalone shell and mother-of-pearl, add ten times the weight of water and decoct for 1-3 hours. Add other Chinese medicinal materials and make up the water volume to ten times the weight of all medicinal materials. Decoction twice, 2 hours each time. Combine the decoctions, filter, concentrate the filtrate to an extract with a relative density of 1.10 at 80℃, and set aside. (2) Add ethanol to make the alcohol content reach 50%-75%, stir continuously, let stand for 12-48 hours, filter, recover ethanol from the filtrate under reduced pressure to clean and concentrate to an extract with a relative density of 1.05-1.10 at 50℃. After drying the extract, pulverize it into dry extract powder for later use. (3) Take the dry powder, crush it, add excipients, and make a pharmaceutical preparation.

5. The Gastrodia elata compound composition for treating vertigo as described in claim 4, characterized in that: The dosage form of the pharmaceutical preparation is one of the following: tablets, capsules, or granules.

6. The use of the Gastrodia elata compound composition for treating vertigo as described in claim 1 in the preparation of a drug for treating vertigo.

7. The use of the Gastrodia elata compound composition for treating vertigo as described in claim 1 in the preparation of a drug for treating vertigo, characterized in that: The type of dizziness belongs to the syndrome of liver yang hyperactivity caused by internal accumulation of phlegm and turbidity.

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