An Azithromycin Dispersible Tablet Preparation System

Abstract

This invention discloses an azithromycin dispersible tablet preparation system, including a fixed platform, a sliding platform slidably connected to the upper end of the fixed platform, guide rails fixed on the front and rear sides of the left side of the upper end of the sliding platform, and a tableting mold fixed on the upper side between the guide rails. The tableting mold has a mold hole on its upper side. By moving the sliding plate below the tableting mold, the sliding plate can provide support during the tableting of powdered azithromycin. After tableting, the screw is driven by a screw motor to rotate, and the screw is threadedly connected to the sliding plate, causing the sliding plate to move to the right away from directly under the tableting mold. Then, the hydraulic cylinder moves the tableting plate down, pushing the formed azithromycin dispersible tablet onto the sliding platform. Then, the sliding plate moves to the left and slides under the tableting mold, which pushes the azithromycin dispersible tablet on the sliding platform to the right away from directly under the tableting mold. This eliminates the need for manual removal of the formed azithromycin dispersible tablet, saving manpower.

Description

Technical Field

[0001] This invention relates to the field of azithromycin dispersible tablet preparation technology, specifically to an azithromycin dispersible tablet preparation system. Background Technology

[0002] Azithromycin belongs to the macrolide antibiotic class and has unique pharmacokinetic characteristics, including a long biological half-life, high tissue penetration, good chemical and biological stability, broad antibacterial spectrum, few adverse reactions, and good tolerability. Clinically, it is widely used for respiratory tract, skin and soft tissue, and genitourinary system infections. Currently, the dosage forms of this drug available in China include ordinary tablets, dispersible tablets, capsules, granules, and dry suspensions. This invention focuses on the field of efficient preparation technology for azithromycin dispersible tablets, aiming to solve the key problems currently faced. As a widely used antibiotic, the preparation of azithromycin dispersible tablets requires a complex tableting process. Especially after compressing the powder raw material, traditionally, the mold base needs to be manually removed and repeated compression is required. This process is not only cumbersome and labor-intensive but also inefficient, limiting the potential for mass production.

[0003] The current challenge in azithromycin dispersible tablet preparation technology lies in the excessive reliance on manual intervention in post-compression processing, which limits production efficiency. Specifically:

[0004] 1. Manual removal of the mold base and re-pressing are cumbersome and increase manpower burden; 2. The low level of automation in the production line affects continuity and unstable yield; 3. The finished product relies on manual handling, which can easily lead to efficiency bottlenecks. Summary of the Invention

[0005] The purpose of this invention is to overcome the deficiencies of the prior art and provide an azithromycin dispersible tablet preparation system to solve the problems existing in the background art.

[0006] An azithromycin dispersible tablet preparation system includes a fixed platform, a sliding platform slidably connected to the upper end of the fixed platform, guide rails fixed on the front and rear sides of the left side of the upper end of the sliding platform, a tableting mold fixed on the upper side between the guide rails, a mold hole on the upper side of the tableting mold, a sliding plate slidably connected between the guide rails and below the tableting mold, the top surface of the sliding plate slidably connected to the bottom surface of the tableting mold, a lead screw motor fixedly installed at the right end of the sliding platform, a lead screw connected to the output end of the lead screw motor, the end of the lead screw threadedly connected to the sliding plate, a vertical plate fixed at the rear end of the fixed platform, a hydraulic cylinder installed at the upper end of the vertical plate, the piston rod end of the hydraulic cylinder penetrating the vertical plate and fixing a tableting plate, and a tableting column assembly corresponding to the mold hole installed at the lower part of the tableting plate.

[0007] Preferably, the upper end of the fixed platform has a groove, a rotating shaft is rotatably connected inside the groove, a gear is fixed outside the rotating shaft, a drive motor is fixedly installed at the middle of the front end of the fixed platform, the output end of the drive motor is connected to the rotating shaft, and a rack is fixed at the lower end of the sliding platform, the rack is located inside the groove and meshes with the gear.

[0008] Preferably, guide grooves are provided at both the front and rear ends of the inner wall of the groove, and guide bars are fixed at both the front and rear ends of the rack. The guide bars are located inside the guide grooves and are slidably connected to the guide grooves.

[0009] Preferably, a controller is installed at the rear end of the upright plate, a button is installed through the right end of the fixed platform, the right side of the sliding platform is in contact with the button, the button is connected to the controller, and the controller is connected to the drive motor.

[0010] Preferably, a second button is installed through the right side of the sliding table, the right side of the slide plate is in contact with the second button, the second button is connected to the controller, and the controller is connected to the lead screw motor.

[0011] Preferably, the tablet compression column assembly includes a tablet compression column, a sensor seat, and a pressure sensor. The sensor seat is fixed to the tablet compression plate, the pressure sensor is installed in the sensor seat, the upper end of the tablet compression column extends into the sensor seat and contacts the pressure sensor, the pressure sensor is signal-connected to the controller, and the controller is connected to the hydraulic cylinder.

[0012] Preferably, the slide plate has a screw hole in the middle, and the end of the lead screw extends into the screw hole and is threadedly connected to the screw hole. The length of the lead screw end extending into the right interior of the screw hole is one centimeter.

[0013] Preferably, the upright plate is L-shaped, and a reinforcing base is fixed to the inner corner of the upright plate. The reinforcing base has a triangular prism structure.

[0014] The operating procedure for the azithromycin dispersible tablet preparation system includes:

[0015] Initiating the reversal process:

[0016] First, activate the drive motor to reverse the rotating shaft, which in turn drives the gear to reverse as well. The gear meshes with the rack, causing the rack to move to the left in the groove. At this time, the leftward movement of the rack causes the sliding table to move to the left, and the tableting mold moves away from the tableting plate, making it easier for powdered azithromycin to fill the mold hole.

[0017] Preparation for forward rotation of the tablet press:

[0018] Next, the drive motor reverses, causing the shaft and gear to rotate clockwise, which in turn moves the rack to the right. The sliding table moves to the right to the button. Once the button is pressed, a signal is sent to the controller to stop the motor, ensuring that the tableting mold is aligned with the tableting plate for easy material feeding by the worker. Subsequently, the hydraulic cylinder lowers the tableting plate, and the tableting column enters the mold hole to begin tableting. Pressure monitoring and forming: During tableting, the pressure sensor monitors the pressure of the tableting column. Once the preset threshold is reached, the controller commands the hydraulic cylinder to retract, the tableting plate to move upward, and the tableting column to exit the mold hole, completing the tableting process.

[0019] Removing and re-laying the sheet: After molding, the lead screw motor drives the lead screw to turn right, and the lead screw and slide plate move to the right, leaving the mold; when the slide plate touches button two, the signal controller stops the lead screw motor, the hydraulic cylinder moves the sheet plate down again, and the molded sheet falls onto the slide table; finally, the lead screw motor turns left in the opposite direction and the slide plate moves back, pressing the sheet under the mold, and the sheet on the slide table moves to the right and out of the mold, eliminating the need for manual sheet removal and saving manpower.

[0020] Integrated control methods for controllers include:

[0021] To meet the compression requirements of azithromycin dispersible tablets, a customized PID control strategy was implemented in the controller, using P control. The parameters P—proportional coefficient K, integral time I, and derivative time D—were carefully adjusted to precisely control the speed and pressure during the tableting process, maintaining stable and rapid compression force and reducing overshoot.

[0022] Historical data analysis and real-time feedback system construction:

[0023] A historical database is established, recording key pressing parameters: pressure, time, speed, tablet thickness, and finished product quality. The controller analyzes the pressing process in real time based on this database, comparing the tableting force with historical data through real-time sensor feedback to automatically optimize PID parameters, achieving dynamic adjustment and ensuring continuous optimization of the pressing process. Accuracy is adaptively iteratively corrected.

[0024] During the iterative learning process, the PID controller automatically adjusts the tableting parameters, such as pressure and speed, based on the deviation of the finished product, minimizing the deviation and gradually approaching the ideal state to ensure high consistency and accuracy of the finished product; the system adapts to fluctuations in raw materials and continuously outputs stable quality.

[0025] The beneficial effects are as follows:

[0026] 1. By setting the sliding plate below the tableting mold, the sliding plate can provide support during the tableting process of powdered azithromycin. After tableting, the screw is driven by a screw motor to rotate, and the screw is threadedly connected to the sliding plate, which moves the sliding plate to the right away from directly under the tableting mold. Then, the hydraulic cylinder moves the tableting plate down to push the formed azithromycin dispersible tablets onto the sliding table. Then, the sliding plate moves to the left and slides under the tableting mold, which pushes the azithromycin dispersible tablets on the sliding table to the right away from directly under the tableting mold. This eliminates the need for manual removal of the formed azithromycin dispersible tablets, saving manpower.

[0027] 2. When it is necessary to feed the powdered azithromycin dispersible tablet raw material into the die hole of the tableting mold, the gear of the drive motor rotates. As the gear meshes with the rack, the rack moves to the left, driving the sliding table to move to the left. This moves the tableting mold away from directly under the tableting plate, making it easier to feed the powdered azithromycin dispersible tablet into the die hole. Then, the tableting mold is moved back to directly under the tableting plate for tableting, thus facilitating the feeding process for workers. Labor savings: The automated sliding tablet transfer mechanism effectively replaces manual tablet handling, saving significant labor costs, improving production efficiency, and enabling efficient continuous operation.

[0028] Improved yield: Precise control and adaptive adjustment ensure high consistency of finished products, significantly improving the yield and meeting high standards.

[0029] Intelligentization: The integration of PID algorithm with a real-time database feedback system enables intelligent pressing process, adaptive optimization, and improved overall intelligent production level.

[0030] Stable quality: Adaptability to raw material fluctuations is ensured through algorithmic iterative learning, resulting in stable finished product quality, reduced fluctuations, and compliance with GMP standards. Attached Figure Description

[0031] Figure 1 This is a schematic diagram of the overall invention;

[0032] Figure 2 This is a schematic cross-sectional view of the fixing platform of the present invention;

[0033] Figure 3 This is a schematic cross-sectional view of the tableting column of the present invention.

[0034] In the diagram: 1-Fixed platform, 2-Sliding platform, 3-Guide rail, 4-Slide plate, 5-Pressure mold, 6-Mold hole, 7-Upright plate, 8-Reinforcing base, 9-Controller, 10-Hydraulic cylinder, 11-Pressure plate, 12-Pressure column, 13-Screw motor, 14-Screw, 15-Drive motor, 16-Button 1, 17-Button 2, 18-Groove, 19-Rotating shaft, 20-Gear, 21-Rack, 22-Guide bar, 23-Guide groove, 24-Sensor seat, 25-Pressure sensor. Detailed Implementation

[0035] Please see Figures 1-3 An azithromycin dispersible tablet preparation system includes a fixed platform 1, a sliding platform 2 slidably connected to the upper end of the fixed platform 1, a groove 18 on the upper end of the fixed platform 1, a rotating shaft 19 rotatably connected inside the groove 18, a gear 20 fixed outside the rotating shaft 19, a drive motor 15 fixedly installed at the front end of the fixed platform 1, the output end of the drive motor 15 connected to the rotating shaft 19, a rack 21 fixed at the lower end of the sliding platform 2, the rack 21 located inside the groove 18 and meshing with the gear 20, and the drive motor 15 externally connected to a reversing switch and a power supply. Thus, the drive motor 15 can drive the rotating shaft 19 to rotate forward or reverse, and the rotating shaft 19 will drive the gear 20 to rotate forward or reverse. Through the meshing of the gear 20 and the rack 21, the rack 21 moves left and right within the groove 18. When the rack 21 moves to the left, it will drive the sliding platform 2 to move to the left, and when the rack 21 moves to the right, it will drive the sliding platform 2 to move to the right.

[0036] The inner wall of the groove 18 has guide grooves 23 at both the front and rear ends, and the rack 21 has guide bars 22 fixed at both the front and rear ends. The guide bars 22 are located inside the guide grooves 23 and are slidably connected to the guide grooves 23. When the rack 21 moves left and right, it will drive the guide bars 22 to move inside the guide grooves 23. In this way, the guide bars 22 and the guide grooves 23 cooperate to guide the rack 21.

[0037] The upper left side of the sliding table 2 is fixed with guide rails 3 on both the front and rear sides. A tableting mold 5 is fixed on the upper side between the guide rails 3. The tableting mold 5 has a mold hole 6 on its upper side. A sliding plate 4 is slidably connected between the guide rails 3 and below the tableting mold 5. The top surface of the sliding plate 4 is slidably connected to the bottom surface of the tableting mold 5. A lead screw motor 13 is fixedly installed on the right end of the sliding table 2. The output end of the lead screw motor 13 is connected to a lead screw 14. The end of the lead screw 14 is threadedly connected to the sliding plate 4. The middle part of the sliding plate 4... A screw hole is provided, and the end of the lead screw 14 extends into the screw hole and is threaded into it. The extension length of the end of the lead screw 14 inside the screw hole is one centimeter. A vertical plate 7 is fixed to the rear end of the fixed platform 1. A hydraulic cylinder 10 is installed on the upper end of the vertical plate 7. The piston rod end of the hydraulic cylinder 10 passes through the vertical plate 7 and is fixed to a pressing plate 11. A pressing column assembly corresponding to the die hole 6 is installed on the lower part of the pressing plate 11. The lead screw motor 13 is externally connected to a reversing switch and a power supply. Thus, the lead screw motor... The motor 13 can drive the lead screw 14 to rotate forward or backward. The lead screw 14 engages with the threaded hole of the slide plate 4 to move the slide plate 4 left and right. By movably positioning the slide plate 4 below the tableting mold 5, the hydraulic cylinder 10 can drive the tableting plate 11 to move downward, allowing the tableting column assembly to be inserted into the mold hole 6 of the tableting mold 5 to compress the powdered azithromycin into tablets. The slide plate 4 provides support during this process. After tableting, the motor 13 drives the lead screw 14 to rotate forward, and the lead screw 14 engages with the slide plate 4 to move left and right. The plate 4 is threaded, which drives the slide plate 4 to move to the right away from directly below the tableting mold 5. Then, the hydraulic cylinder 10 drives the tableting plate 11 to move down, pushing the formed azithromycin dispersible tablets out of the mold hole 6 and onto the sliding table 2. Then, the screw motor 13 drives the screw 14 to rotate in reverse, causing the slide plate 4 to move to the left and slide into directly below the tableting mold 5. This will push the azithromycin dispersible tablets on the sliding table 2 to the right away from directly below the tableting mold 5. This eliminates the need for manual removal of the formed azithromycin dispersible tablets, saving manpower.

[0038] A controller 9 is installed at the rear end of the upright plate 7. A button 16 is installed through the right end of the fixed platform 1. The right side of the sliding platform 2 contacts the button 16. The button 16 is connected to the controller 9 by signal, and the controller 9 is connected to the drive motor 15 by signal. When the sliding platform 2 moves to the right and contacts the button 16, the button 16 will be pressed once. The button 16 is pressed once and sends a signal to the controller 9. The button 16 will not continuously send a signal to the controller 9 if it is continuously pressed. The controller 9 will control the drive motor 15 to stop. This ensures that after the sliding platform 2 moves to the right and is in close contact with the right side of the fixed platform 1, the drive motor 15 will not be damaged due to the continuous rightward movement of the sliding platform 2.

[0039] A second button 17 is installed through the right side of the sliding platform 2. The right side of the slide plate 4 contacts the second button 17. The second button 17 is connected to the controller 9, and the controller 9 is connected to the lead screw motor 13. When the slide plate 4 moves to the right and contacts the second button 17, the second button 17 will be pressed once. The second button 17 sends a signal to the controller 9 once it is pressed. The second button 17 will not continuously send a signal to the controller 9 if it is continuously pressed. The controller 9 will control the lead screw motor 13 to stop, so as to ensure that the lead screw motor 13 will not be damaged when the slide plate 4 moves to the right and is in close contact with the right side of the sliding platform 2.

[0040] The tableting column assembly includes a tableting column 12, a sensor seat 24, and a pressure sensor 25. The sensor seat 24 is fixed to the tableting plate 11, and the pressure sensor 25 is installed in the sensor seat 24. The upper end of the tableting column 12 extends into the sensor seat 24 and contacts the pressure sensor 25. The pressure sensor 25 is connected to the controller 9, and the controller 9 is connected to the hydraulic cylinder 10. When the tableting column 12 is inserted into the die hole 6 for tableting, the pressure sensor 25 is used to detect the pressure on the tableting column 12 during tableting. When the detected threshold reaches the threshold set in the controller 9, the controller 9 will control the hydraulic cylinder 10 to contract and move the tableting plate 11 upward, which can be used for automated applications.

[0041] The upright plate 7 is L-shaped, and a reinforcing seat 8 is fixed to the inner corner of the upright plate 7. The reinforcing seat 8 is a triangular prism structure. By setting the reinforcing seat 8, the inner corner of the upright plate 7 can be reinforced.

[0042] Working principle: By driving the drive motor 15 to reverse the rotation of the shaft 19, the shaft 19 will drive the gear 20 to reverse. The gear 20 meshes with the rack 21, causing the rack 21 to move to the left within the groove 18. When the rack 21 moves to the left, it will cause the sliding table 2 to move to the left, thus moving the tablet mold 5 away from directly below the tablet plate 11. This facilitates the loading of powdered azithromycin dispersible tablets into the mold hole 6 of the tablet mold 5. Then, by driving the drive motor 15 to rotate the shaft 19 clockwise, the shaft 19 will drive the gear 20 clockwise, and the gear 20 meshes with the rack 21. 1. Engagement causes the rack 21 to move to the right within the groove 18. As the rack 21 moves to the right, it drives the sliding table 2 to move to the right. When the sliding table 2 moves to the right and contacts the button 16, the button 16 is pressed once. This press signal is sent to the controller 9, which then stops the drive motor 15. This allows the tableting mold 5 to move directly below the tableting plate 11, facilitating material loading by the worker. Afterwards, the hydraulic cylinder 10 drives the tableting plate 11 downward, and the tableting plate 11 drives the tableting column 12 to insert into the mold hole 6. During the tableting process, pressure sensor 25 detects the pressure on the tableting column 12. When the detected threshold reaches the threshold set in controller 9, controller 9 controls hydraulic cylinder 10 to contract, causing tableting plate 11 to move upward, thus pulling tableting column 12 out of mold hole 6. After tableting, simply drive screw 14 to rotate forward via screw motor 13. Screw 14 is threadedly connected to slide plate 4, causing slide plate 4 to move to the right away from directly below tableting mold 5. When slide plate 4 moves to the right and contacts button 17, button 17 will be activated. Pressing button 17 once sends a signal to controller 9, which then stops the lead screw motor 13. The hydraulic cylinder 10 then moves the tableting plate 11 down, pushing the formed azithromycin dispersible tablet out of the die hole 6 and onto the sliding table 2. The lead screw motor 13 then drives the lead screw 14 to rotate in reverse, causing the slide plate 4 to slide to the left and into the area directly under the tableting mold 5. This pushes the azithromycin dispersible tablet on the sliding table 2 to the right, away from the area directly under the tableting mold 5. This eliminates the need for manual removal of the formed azithromycin dispersible tablet, saving manpower.

[0043] This application also discloses an operating method for an azithromycin dispersible tablet preparation system, including:

[0044] Initiating the reversal process:

[0045] First, activate the drive motor to reverse the rotating shaft, which in turn drives the gear to reverse as well. The gear meshes with the rack, causing the rack to move to the left in the groove. At this time, the leftward movement of the rack causes the sliding table to move to the left, and the tableting mold moves away from the tableting plate, making it easier for powdered azithromycin to fill the mold hole.

[0046] Preparation for forward rotation of the tablet press:

[0047] Next, the drive motor reverses, causing the shaft and gear to rotate clockwise, which in turn moves the rack to the right. The sliding table moves to the right to the button. Once the button is pressed, a signal is sent to the controller to stop the motor, ensuring that the tableting mold is aligned with the tableting plate for easy material feeding by the worker. Subsequently, the hydraulic cylinder lowers the tableting plate, and the tableting column enters the mold hole to begin tableting. Pressure monitoring and forming: During tableting, the pressure sensor monitors the pressure of the tableting column. Once the preset threshold is reached, the controller commands the hydraulic cylinder to retract, the tableting plate to move upward, and the tableting column to exit the mold hole, completing the tableting process.

[0048] Removing and re-laying the sheet: After molding, the lead screw motor drives the lead screw to turn right, and the lead screw and slide plate move to the right, leaving the mold; when the slide plate touches button two, the signal controller stops the lead screw motor, the hydraulic cylinder moves the sheet plate down again, and the molded sheet falls onto the slide table; finally, the lead screw motor turns left in the opposite direction and the slide plate moves back, pressing the sheet under the mold, and the sheet on the slide table moves to the right and out of the mold, eliminating the need for manual sheet removal and saving manpower.

[0049] In further implementation, this application integrates the algorithm into controller 9. Based on historical tableting data learning and real-time feedback, it automatically adjusts tableting parameters (such as pressure, speed, and time) to ensure high consistency and accuracy of each batch of tablets, thereby improving the yield. Specific implementation details are as follows:

[0050] 1. Customized integration of PID control strategies

[0051] First, considering the characteristics of the azithromycin dispersible tablet compression process, a specific PID control was designed and integrated into the controller 9. A customized PID (proportional-integral-derivative-derivative) control strategy was integrated. By adjusting the parameters Kp (proportional constant), I (integral time constant), and D (derivative time constant), the pressure and speed during the tablet compression process were precisely controlled to ensure the stability and rapid response of the compression force, reduce overshoot, achieve consistency between batches, and thus improve the finished product qualification rate.

[0052] 2. Historical data analysis and real-time feedback loop

[0053] A historical database is established to store key parameters (such as pressure, time, tableting speed, tableting thickness, etc.) and finished product quality data for each pressing process. The controller 9 uses this database as a learning basis to analyze the pressing process in real time. It collects real-time feedback information on the force on the tableting column through the sensor 25, compares it with the tableting status and historical data, and automatically fine-tunes the PID parameters to achieve dynamic adjustment and ensure continuous optimization of the pressing process.

[0054] 3. Accuracy and Adaptability Adjustment

[0055] Through iterative learning of the algorithm, after each tablet compression, the PID controller 9 automatically adjusts the tableting parameters, such as pressure and speed, based on the deviation of the actual finished product to minimize the deviation and gradually approach the ideal tableting effect, ensuring high consistency and accuracy of the finished product. In continuous production, the system can adapt to fluctuations in raw materials and maintain stable output quality.

[0056] The details outlined above not only enhance the intelligence and adaptability of controller 9 in the technical solution but also closely integrate various components of the existing technical solution (such as the tableting column assembly, sensors, hydraulic cylinders, slide plates, motors, etc.) to form a closed-loop control system. Through a PID control strategy, precise regulation of the tableting process is achieved, and optimization is learned based on historical feedback data, ensuring consistency between batches and ultimately improving the yield rate. This approach is consistent with the overall technical solution and highly efficient. It not only saves manpower but also improves the production efficiency and quality of azithromycin dispersible tablets, aligning with the trend of automation and intelligence in the modern pharmaceutical industry.

[0057] PID control, or Proportional-Integral-Derivative (PID) control, is a feedback control strategy widely used in automatic control systems to maintain the system output consistent with the desired value. It compensates for and corrects system errors by combining three basic control behaviors:

[0058] Proportional control (P):

[0059] This is the most direct form of control, where the controller output is proportional to the current error. The error E(t) is directly proportional, i.e., the output U(t) = Kp × E(t), where Kp is the proportional gain coefficient. Proportional control responds quickly to errors but does not eliminate steady-state errors.

[0060] Integral control (I): Integral control considers the cumulative effect of error over time. If the error persists, the controller output will increase cumulatively until the steady-state error is eliminated. Output U(t) = Ki∫E(τ)dτ + other τ. Ki is the integral time constant, ensuring that the system eventually has zero steady-state error, but may cause slow response and overshoot.

[0061] Derivative control (D): Considers the rate of error change, predicts future error trends, and adjusts the output in advance to reduce overshoot. U(t) = KdE(t) / dt + others, where Kd is the derivative time constant. Derivative control offers fast response and rapid oscillation suppression, but is sensitive to noise.

[0062] This application also discloses an integrated control method for the controller of an azithromycin dispersible tablet preparation system, including:

[0063] To meet the compression requirements of azithromycin dispersible tablets, a customized PID control strategy was implemented in the controller, using P control. The parameters P—proportional coefficient K, integral time I, and derivative time D—were carefully adjusted to precisely control the speed and pressure during the tableting process, maintaining stable and rapid compression force and reducing overshoot.

[0064] Historical data analysis and real-time feedback system construction:

[0065] A historical database is established, and key pressing parameters such as pressure, time, speed, tablet thickness, and finished product quality are entered. The controller analyzes the pressing process in real time based on this database, compares the tableting force with historical data through real-time data feedback from sensors, automatically optimizes PID parameters, achieves dynamic adjustment, and ensures continuous optimization of the pressing process.

[0066] Accuracy adaptive iterative correction:

[0067] During the iterative learning process, the PID controller automatically adjusts the tableting parameters, such as pressure and speed, based on the deviation of the finished product, minimizing the deviation and gradually approaching the ideal state to ensure high consistency and accuracy of the finished product; the system adapts to fluctuations in raw materials and continuously outputs stable quality.

[0068] The azithromycin dispersible tablet preparation system proposed in this invention is an innovative achievement aimed at comprehensively revolutionizing the field of antibiotic formulation technology. Through highly automated and intelligent design, it solves the labor-intensive problems of traditional preparation processes, significantly improving production efficiency and the consistency of finished product quality. The following is a comprehensive overview of the system's overall technological achievements:

[0069] Overview of Technological Innovations:

[0070] Automated support and intelligent tablet removal technology: Through an innovatively designed sliding plate mechanism, the tablets are automatically removed after compression molding without manual intervention, greatly reducing the labor burden and improving production efficiency.

[0071] Precision control system: Integrated PID control strategy: The customized PID algorithm in controller 9 accurately adjusts parameters such as pressure and speed based on historical data feedback, ensuring high consistency of each batch of tablets and significantly improving the yield.

[0072] Real-time feedback and dynamic optimization database construction: Real-time database construction dynamically records pressing parameters, combines them with sensor data feedback, automatically optimizes PID parameters, continuously improves the pressing process, and ensures the optimal pressing process.

[0073] Adaptive iterative correction: The algorithm automatically adjusts the tableting parameters based on the deviation of the finished product, gradually approaching the ideal state. The system adapts to raw material fluctuations, ensures stable output of finished product quality, and improves production flexibility.

[0074] Technical Implementation Results:

[0075] Labor saving: The automated slide plate transfer mechanism effectively replaces manual plate picking, saving a lot of labor costs, improving production efficiency, and achieving efficient continuous operation.

[0076] Improved yield: Precise control and adaptive adjustment ensure high consistency of finished products, significantly improving the yield and meeting high standards.

[0077] Intelligentization: The integration of PID algorithm with a real-time database feedback system enables intelligent pressing process, adaptive optimization, and improved overall intelligent production level.

[0078] Stable quality: Adaptability to raw material fluctuations is ensured through algorithmic iterative learning, resulting in stable finished product quality, reduced fluctuations, and compliance with GMP standards.

[0079] The technical solutions of this disclosure have been described in conjunction with several embodiments above. However, it is readily understood by those skilled in the art that the scope of protection of this disclosure is not limited to these specific embodiments. Without departing from the technical principles of this disclosure, those skilled in the art can disassemble and combine the technical solutions in the above embodiments, and can also make equivalent changes or substitutions to related technical features. Any changes, equivalent substitutions, improvements, etc., made within the technical concept and / or technical principles of this disclosure will fall within the scope of protection of this disclosure.

Claims

1. An azithromycin dispersible tablet preparation system, comprising a fixed stage (1), characterized in that: A sliding platform (2) is slidably connected to the upper end of the fixed platform (1). Guide rails (3) are fixed on the front and rear sides of the upper left part of the sliding platform (2). A tablet pressing mold (5) is fixed on the upper side between the guide rails (3). A mold hole (6) is provided on the upper side of the tablet pressing mold (5). A sliding plate (4) is slidably connected between the guide rails (3) and below the tablet pressing mold (5). The top surface of the sliding plate (4) is slidably connected to the bottom surface of the tablet pressing mold (5). A lead screw motor (13) is fixedly installed on the right end of the sliding platform (2). A lead screw (14) is connected to the output end of the lead screw motor (13). The end of the lead screw (14) is threadedly connected to the sliding plate (4). A vertical plate (7) is fixed at the rear end. A hydraulic cylinder (10) is installed at the upper end of the vertical plate (7). The piston rod of the hydraulic cylinder (10) passes through the vertical plate (7) and is fixed with a pressing plate (11). A pressing column assembly corresponding to the mold hole (6) is installed at the lower part of the pressing plate (11). After molding, the screw motor drives the screw to turn right, and the screw drives the slide plate to move to the right and away from the mold. When the slide plate touches the second button, the signal controller stops the screw motor, the hydraulic cylinder moves the pressing plate down again, and the molded piece falls to the sliding table. Finally, the screw motor turns left in the opposite direction and the slide plate moves back, so that the slide plate moves to the left and slides into the pressing mold directly below, and pushes the molded piece on the sliding table to the left away from the pressing mold directly below.

2. The azithromycin dispersible tablet preparation system according to claim 1, characterized in that: The fixed platform (1) has a groove (18) at its upper end. A rotating shaft (19) is rotatably connected inside the groove (18). A gear (20) is fixed outside the rotating shaft (19). A drive motor (15) is fixedly installed at the middle of the front end of the fixed platform (1). The output end of the drive motor (15) is connected to the rotating shaft (19). A rack (21) is fixed at the lower end of the sliding platform (2). The rack (21) is located inside the groove (18) and meshes with the gear (20).

3. The azithromycin dispersible tablet preparation system according to claim 2, characterized in that: The inner wall of the groove (18) has guide grooves (23) at both the front and rear ends, and the rack (21) has guide bars (22) fixed at both the front and rear ends. The guide bars (22) are located inside the guide grooves (23) and are slidably connected to the guide grooves (23).

4. The azithromycin dispersible tablet preparation system according to claim 3, characterized in that: The rear end of the upright plate (7) is equipped with a controller (9), and the right end of the fixed platform (1) is equipped with a button (16). The right side of the sliding platform (2) is in contact with the button (16). The button (16) is connected to the controller (9) by signal, and the controller (9) is connected to the drive motor (15) by signal.

5. The azithromycin dispersible tablet preparation system according to claim 4, characterized in that: A second button (17) is installed through the right side of the sliding table (2). The right side of the slide plate (4) is in contact with the second button (17). The second button (17) is connected to the controller (9) via signal. The controller (9) is connected to the lead screw motor (13) via signal.

6. The azithromycin dispersible tablet preparation system according to claim 5, characterized in that: The tablet compression column assembly includes a tablet compression column (12), a sensor seat (24), and a pressure sensor (25). The sensor seat (24) is fixed to the tablet compression plate (11), and the pressure sensor (25) is installed in the sensor seat (24). The upper end of the tablet compression column (12) extends into the sensor seat (24) and contacts the pressure sensor (25). The pressure sensor (25) is signal-connected to the controller (9), and the controller (9) is connected to the hydraulic cylinder (10).

7. The azithromycin dispersible tablet preparation system according to claim 1, characterized in that: The slide plate (4) has a screw hole in the middle. The end of the lead screw (14) extends into the screw hole and is threadedly connected to the screw hole. The length of the end of the lead screw (14) extending into the right interior of the screw hole is one centimeter.

8. The azithromycin dispersible tablet preparation system according to claim 1, characterized in that: The upright plate (7) is L-shaped, and a reinforcing base (8) is fixed to the inner corner of the upright plate (7). The reinforcing base (8) is a triangular prism structure.

9. The operating method of the azithromycin dispersible tablet preparation system according to claim 6, characterized in that, include: Initiating the reversal process: First, activate the drive motor to reverse the rotating shaft, which in turn drives the gear to reverse as well. The gear meshes with the rack, causing the rack to move to the left in the groove. At this time, the leftward movement of the rack causes the sliding table to move to the left, and the tableting mold moves away from the tableting plate, making it easier for powdered azithromycin to fill the mold hole. Preparation for forward rotation of the tablet press: Next, the drive motor reverses, causing the shaft and gear to rotate clockwise, which in turn moves the rack to the right. The sliding table moves to the right to the button, and when the button is pressed, a signal is sent to the controller to stop the motor, ensuring that the tableting mold is aligned with the tableting plate. Subsequently, the hydraulic cylinder lowers the tableting plate, and the tableting column enters the mold hole to begin tableting. Pressure monitoring and forming: During tableting, the pressure sensor monitors the pressure of the tableting column. Once the preset threshold is reached, the controller commands the hydraulic cylinder to retract, the tableting plate to move upward, and the tableting column to exit the mold hole, completing the tableting process. Removal and re-laying of sheet: After molding, the lead screw motor drives the lead screw to turn right, and the lead screw drives the slide plate to move to the right and away from the mold; when the slide plate touches button two, the signal controller stops the lead screw motor, the hydraulic cylinder moves the pressing plate down again, and the molded sheet falls onto the sliding table; finally, the lead screw motor turns left in the opposite direction and the slide plate moves back, so that the slide plate moves to the left and slides into the underside of the pressing mold, and pushes the molded sheet on the sliding table to the left and away from the underside of the pressing mold.

10. The integrated control method for the controller of the azithromycin dispersible tablet preparation system according to claim 6, characterized in that, include: To address the compression requirements of azithromycin dispersible tablets, a customized PID control strategy was implemented in the controller, using P control. Detailed adjustment of parameters P: proportional coefficient K, integral time I, and derivative time D, to accurately control the speed and pressure of the tableting process, maintain stable and rapid compression force, and reduce overshoot; Historical data analysis and real-time feedback system construction: A historical database is established, and key pressing parameters such as pressure, time, speed, tablet thickness, and finished product quality are entered. The controller analyzes the pressing process in real time based on the historical database, compares the tableting force with the historical data through real-time data feedback from sensors, automatically optimizes PID parameters, achieves dynamic adjustment, and ensures continuous optimization of the pressing process. Accuracy adaptive iterative correction: During algorithm iterative learning, the PID controller automatically adjusts the tableting parameters—pressure and speed—based on the deviation of the finished product, minimizing the deviation and gradually approaching the ideal state to ensure high consistency and accuracy of the finished product; the system adapts to raw material fluctuations and continuously outputs stable quality.

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