Rat animal model interventional therapy positioning device

Abstract

The present invention relates to the field of animal model technology, and in particular to a positioning device for interventional treatment of a rat animal model, comprising a feeding box and a switch door arranged on the feeding box, wherein two opposite outer walls of the feeding box are fixedly connected with connecting blocks, a placement box is arranged on the connecting blocks, a driving mechanism and a clamping mechanism are arranged in the placement box, two opposite outer walls of the placement box at one end close to the feeding box are fixedly connected with counterweight blocks, a bearing platform is arranged in the inner cavity of the feeding box for sliding up and down, and a lifting component is fixedly connected between the lower surface of the bearing platform and the inner wall of the feeding box. The positioning device for interventional treatment of a rat animal model provided by the present invention drives the rat into the placement box by rotating a sleeve plate and a movable plug plate, and then further drives the rat by a rotating plate and a clamping roller, and then the bottom end of the arc-shaped splint is clamped on the rat to fix it, and no manual trunk and fixation are required, which is efficient and safe.

Description

Technical Field

[0001] The invention relates to the technical field of animal models, in particular to a positioning device for interventional treatment of rat animal models. Background Art

[0002] Animal model experiments are usually required in basic biological research. Since the gene sequence of the mouse model is similar to that of humans, the genetic stability is high, the reproduction volume is large and the breeding cost is low, the most commonly used animal model in animal model experiments is the mouse model, of which the rat model is also a type of mouse model.

[0003] At present, rats are commonly used experimental animals and are widely used in medical biology for research in pharmacology, cardiovascular disease, oncology, nutrition and behavior. In medical experiments, rats need to be subjected to interventional treatment (such as injection). In the prior art, rat models are mostly kept in cages. When an injection is required, the staff needs to take the rat out of the cage, fix the rat's body and tail, and then perform a tail vein injection. However, since rats are living beings and will run, it may take a while for the staff to catch them, and the subsequent fixation of the rats may easily cause the staff to be scratched or bitten. Summary of the invention

[0004] In order to solve the above problems, the present invention provides a positioning device for interventional treatment of rat animal models.

[0005] The present invention adopts the following technical scheme: a positioning device for interventional treatment of a rat animal model, comprising a feeding box and a switch door arranged on the feeding box, wherein two opposite outer walls of the feeding box are fixedly connected with connecting blocks, a placement box is arranged on the connecting blocks, a driving mechanism and a clamping mechanism are arranged in the placement box, two opposite outer walls of the placement box at one end close to the feeding box are fixedly connected with counterweight blocks, a bearing platform is arranged in the inner cavity of the feeding box for sliding up and down, a lifting assembly is fixedly connected between the lower surface of the bearing platform and the inner wall of the feeding box, and a rotating sleeve is rotatably arranged on the upper side of the bearing platform located on the inner wall of the feeding box;

[0006] The driving mechanism includes a lifting arc plate that is slidably arranged on the lower surface of the inner cavity of the placement box, and the lifting arc plate is arranged away from the feeding box. Sliding rods are arranged at two opposite positions on the lower side of the lifting arc plate in the placement box, and the sliding rods are horizontally slidably arranged in the placement box. The two opposite sides of the bottom end of the lifting arc plate are slidably arranged on the sliding rods. A fourth spring is fixedly connected between the bottom end of the lifting arc plate and the placement box. A toggle rod and a toggle block are arranged on the upper end of the sliding rod, and the toggle block is arranged close to the lifting arc plate. A winding roller is rotatably arranged at the bottom end of the placement box close to the feeding box. The winding roller A pull rope is wound around the middle outer wall, and the other end of the pull rope is fixed to the outer wall of the feeding box, both ends of the winding roller are fixed with gears rotatably arranged in the placement box, a first torsion spring is fixed between the outer walls at both ends of the winding roller and the placement box, a spur rack is meshed and connected to the upper side of the gear, and the spur rack is slidably arranged in the placement box, a sliding block is fixed to the upper end of the spur rack, and the sliding block is horizontally slidably arranged on the inner wall of the placement box, a central axis is rotatably arranged in the sliding block, one end of the central axis extending to the lower side of the sliding block is fixed with a rotating rod, and a rotating plate is fixed to the upper end of the central axis.

[0007] As a further description of the above technical solution: a second torsion spring is fixedly connected between the outer wall of one end of the central rotating shaft of the rotating sleeve and the feeding box, the rotating sleeve is provided with two, and the two rotating sleeves are respectively close to the placement boxes arranged on both sides, a movable plug plate is movably inserted into the bottom end of the rotating sleeve, a first spring is fixedly connected between the upper end of the movable plug plate and the rotating sleeve, and shielding frames are fixedly connected to the two opposite sides of the upper surface of the supporting platform, and the shielding frame is located between the rotating sleeve and the placement box.

[0008] As a further description of the above technical solution: a plug-in frame is movably connected to the lower side of one end of the rotating plate away from the feeding box, and a second spring is fixedly connected between one end of the plug-in frame located inside the rotating plate and the rotating plate, a clamping roller is rotatably provided at one end of the plug-in frame extending outside the rotating plate, a fixed block is fixedly connected inside the sliding block, and a third spring is fixedly connected between one end of the central axis and the fixed block.

[0009] As a further description of the above technical solution: the clamping mechanism includes a connecting sleeve block fixedly connected to the middle part of the bottom end of the lifting arc plate, a baffle frame is provided on the side of the connecting sleeve block away from the feeding box, and the baffle frame is horizontally slidably arranged in the placement box, a sixth spring is fixedly connected between the side wall of the bottom end of the baffle frame and the placement box, a trapezoidal groove is provided on the upper end of the connecting sleeve block near the side wall of the baffle frame, the upper end of the baffle frame is in contact with a connecting slide rod, and the connecting slide rod is slid up and down in the placement box, a fifth spring is fixedly connected between the upper end of the connecting slide rod and the placement box, an arc-shaped splint is estimated to be provided on the upper end of the connecting slide rod near the side wall of the feeding box, and the arc-shaped splint is slid up and down on the inner wall of the placement box, and a pulling block is fixedly connected to the upper end of the connecting slide rod away from the side wall of the feeding box.

[0010] As a further description of the above technical solution: a rotating shaft is fixedly connected to the bottom end of the placement box, and the rotating shaft is rotatably set on the connecting block, a fixed connecting block is fixedly connected to the side of the lower surface of the placement box away from the feeding box, a limiting opening is provided at the bottom end of the fixed connecting block, a slot opening is provided on the side wall of the connecting block away from the feeding box, a trapezoidal limiting rod is movably inserted on the upper side of the inner wall of the slot opening, and a seventh spring is fixedly connected between the side wall of one end of the trapezoidal limiting rod extending outside the connecting block and the outer wall of the connecting block.

[0011] As a further description of the above technical solution: friction blocks are provided on two opposite sides of the lifting arc plate in the placement box, and the friction blocks are in conflict with the lifting arc plate.

[0012] As a further description of the above technical solution: a plurality of the toggle rods are arranged at equal intervals, and the toggle rods and the toggle blocks are both located on the side of the rotating rod away from the feeding box.

[0013] As a further description of the above technical solution: the thickness of the toggle block is equal to the thickness of the sliding rod, the thickness of the toggle rod is half of the thickness of the sliding rod, and the toggle rod is arranged close to the winding roller.

[0014] The present invention provides a rat animal model interventional treatment positioning device through improvement, which has the following improvements and advantages compared with the prior art:

[0015] First, the movable plug plate is pressed inwardly while the rotating sleeve plate rotates, so that the movable plug plate conflicts with the supporting platform when the rotating sleeve plate and the movable plug plate drive the rat, so as to prevent a gap between the movable plug plate and the supporting platform from squeezing the rat. Then the rat is driven into the placement box by the movable plug plate. When the rat enters the placement box, the rat will press the lifting arc plate downward due to its own gravity, and then the bottom end of the lifting arc plate will squeeze the sliding rod, so that the sliding rod moves toward the feeding box, and multiple toggle rods will squeeze the rotating rod in turn, so that the rotating rod rotates, thereby rotating the rotating plates on both sides, and the rotation of the rotating plates and the clamping rollers will further drive the rat away. The rat can curl up away from the feeding box, and the head of the rat can face the side away from the feeding box, which can also prevent the rat from escaping from the placement box. The placement box is rotated clockwise. Due to the rotation of the placement box, the pull rope will be pulled out, and the pull rope drives the winding roller to rotate clockwise. Through the transmission of the winding roller, gear, spur rack and sliding block, the sliding block moves toward the side close to the lifting arc plate. When the rotating rod moves to the sliding rod, the sliding rod squeezes the rotating rod, so that the clamping rollers on both sides initially contact the buttocks of the rat, and then the rotating plate continues to rotate, so that the clamping rollers on both sides can gradually contact the tail of the rat, and while clamping the tail of the rat, the tail of the rat can also be straightened;

[0016] Second, the elastic retaining frame will be pressed into the trapezoidal groove, and then the other end of the retaining frame will be away from the connecting slide bar. The connecting slide bar will suddenly move downward through the elastic force of the fifth spring, and the bottom end of the arc-shaped splint can be clamped on the rat instantly to fix the rat's body. After the injection is completed, the trapezoidal limit rod is pulled outward to rotate the placement box to its original position, and the pulling block is pulled upward to release the fixation of the rat. Then the pulling block is shaken several times to drive the rat from the placement box to the feeding box to complete the treatment.

[0017] In summary, the rat is first driven into the placement box by rotating the sleeve plate and the movable plug plate, and then further driven by the rotating plate and the clamping roller, so that the rat's head can face the side away from the feeding box, which can also prevent the rat from escaping from the placement box. After that, the bottom end of the arc-shaped splint is clamped on the rat to fix it, and there is no need for manual trunk and fixation, which is efficient and safe. After the placement box is rotated, the clamping rollers on both sides can gradually collide with the rat's tail, and while clamping the rat's tail, the rat's tail can also be straightened, which is more convenient for subsequent injection steps. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The present invention will be further explained below in conjunction with the accompanying drawings and embodiments:

[0019] Figure 1 Schematic diagram of the structure of the rat animal model interventional treatment positioning device provided by the embodiment of the present invention Figure 1 ;

[0020] Figure 2 Schematic diagram of the structure of the rat animal model interventional treatment positioning device provided by the embodiment of the present invention Figure 2 ;

[0021] Figure 3 A three-dimensional cross-sectional view of a breeding box provided by an embodiment of the present invention;

[0022] Figure 4 A three-dimensional cross-sectional view of a placement box provided by an embodiment of the present invention;

[0023] Figure 5 A schematic diagram of the structure of a shielding frame provided by an embodiment of the present invention;

[0024] Figure 6 A schematic diagram of the structure of a driving mechanism provided by an embodiment of the present invention;

[0025] Figure 7 A schematic diagram of the structure of a winding roller provided in an embodiment of the present invention;

[0026] Figure 8 A schematic diagram of the structure of a sliding rod provided in an embodiment of the present invention;

[0027] Fig. 9A three-dimensional cross-sectional view of a sliding block provided by an embodiment of the present invention;

[0028] Fig.10 A three-dimensional cross-sectional view of a clamping mechanism provided by an embodiment of the present invention;

[0029] Fig.11 for Figure 2 The enlarged view of point A in the middle;

[0030] Fig.12 for Figure 3 The enlarged view of point B in the middle;

[0031] Fig.13 for Figure 4 Enlarged view of point C in the middle;

[0032] Fig.14 for Figure 4 The enlarged view of point D in the middle;

[0033] Fig.15 for Figure 8 Enlarged view of point E in the middle.

[0034] In the figure: 1, feeding box; 2, switch door; 3, placing box; 4, connecting block; 5, counterweight block; 6, bearing platform; 7, lifting assembly; 8, rotating sleeve plate; 9, movable plug plate; 10, first spring; 11, shielding frame; 12, driving mechanism; 121, lifting arc plate; 122, sliding rod; 1221, toggle rod; 1222, toggle block; 123, rotating plate; 124, plug-in frame; 125, clamping roller; 126, pull rope; 127, winding roller; 128, first torsion spring; 129, gear; 1210, spur rack; 1211, sliding block; 1 212, rotating rod; 1213, second spring; 1214, central axis; 1215, fixed block; 1216, third spring; 1217, fourth spring; 13, clamping mechanism; 131, arc clamping plate; 132, connecting slide rod; 133, blocking frame; 134, fifth spring; 135, pulling block; 136, connecting sleeve block; 137, sixth spring; 138, trapezoidal groove; 14, fixed connecting block; 15, trapezoidal limiting rod; 16, slot opening; 17, seventh spring; 18, second torsion spring; 19, limiting opening; 20, rotating shaft; 21, friction block. DETAILED DESCRIPTION

[0035] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the present invention is further described below with reference to specific diagrams. It should be noted that the embodiments and features in the embodiments of the present application can be combined with each other without conflict.

[0036] See also Figure 1 - Fig.15The embodiment of the present invention provides a technical solution: a positioning device for interventional treatment of a rat animal model, comprising a feeding box 1 and a switch door 2 arranged on the feeding box 1, the two opposite outer walls of the feeding box 1 are fixedly connected with connecting blocks 4, the connecting blocks 4 are provided with a placing box 3, the placing box 3 is provided with a driving mechanism 12 and a clamping mechanism 13, the two opposite outer walls of the placing box 3 close to the feeding box 1 are fixedly connected with counterweight blocks 5, the inner cavity of the feeding box 1 is provided with a bearing platform 6 that slides up and down, a lifting component 7 is fixedly connected between the lower surface of the bearing platform 6 and the inner wall of the feeding box 1, and the upper side of the bearing platform 6 is located on the inner wall of the feeding box 1 and is rotatably provided with a rotating sleeve plate 8.

[0037] Specifically, the counterweight 5 is provided to prevent the placement box 3 from tilting when the rat is placed in the placement box 3 .

[0038] In another embodiment provided by the present invention, the driving mechanism 12 includes a lifting arc plate 121 that is slidably arranged on the lower surface of the inner cavity of the placement box 3, and the lifting arc plate 121 is arranged away from the feeding box 1, and the two opposite positions on the lower side of the lifting arc plate 121 are located in the placement box 3 and are provided with sliding rods 122, and the sliding rods 122 are horizontally slidably arranged in the placement box 3, and the two opposite sides of the bottom end of the lifting arc plate 121 are slidably arranged on the sliding rods 122, and the bottom end of the lifting arc plate 121 is fixedly connected to the placement box 3. There is a fourth spring 1217, a toggle rod 1221 and a toggle block 1222 are provided at the upper end of the sliding rod 122, and the toggle block 1222 is arranged close to the lifting arc plate 121, and a winding roller 127 is rotatably arranged at the bottom of the placement box 3 near the feeding box 1, and a pull rope 126 is wound around the outer wall of the middle part of the winding roller 127, and the other end of the pull rope 126 is fixed to the outer wall of the feeding box 1, and both ends of the winding roller 127 are fixedly connected to a gear 129 rotatably arranged in the placement box 3, and both ends of the winding roller 127 A first torsion spring 128 is fixedly connected between the outer wall and the placement box 3, a spur rack 1210 is meshedly connected to the upper side of the gear 129, and the spur rack 1210 is slidably arranged in the placement box 3, a sliding block 1211 is fixedly connected to the upper end of the spur rack 1210, and the sliding block 1211 is horizontally slidably arranged on the inner wall of the placement box 3, a central axis 1214 is rotatably arranged in the sliding block 1211, and one end of the central axis 1214 extending to the lower side of the sliding block 1211 is fixedly connected to a rotating rod 1212, and the central axis 1 A rotating plate 123 is fixedly connected to the upper end of 214, and a plug-in frame 124 is movably plugged into the lower side of one end of the rotating plate 123 away from the feeding box 1, and a second spring 1213 is fixedly connected between one end of the plug-in frame 124 located inside the rotating plate 123 and the rotating plate 123, and a clamping roller 125 is rotatably provided on one end of the plug-in frame 124 extending outside the rotating plate 123, a fixed block 1215 is fixedly connected to the sliding block 1211, and a third spring 1216 is fixedly connected between one end of the central axis 1214 and the fixed block 1215.

[0039] Specifically, the multiple toggle rods 1221 will squeeze the rotary rod 1212 in turn, causing the rotary rod 1212 to rotate, and the rotation of the rotating plate 123 will further drive the rat away. After the placement box 3 is rotated, the clamping roller 125 on the rotating plate 123 can clamp the rat's tail and straighten the rat's tail, which is more convenient for subsequent tail injection.

[0040] In another embodiment provided by the present invention, a second torsion spring 18 is fixedly connected between the outer wall of one end of the central shaft of the rotating sleeve 8 and the feeding box 1, and two rotating sleeves 8 are provided. The two rotating sleeves 8 are respectively close to the placement boxes 3 arranged on both sides, and a movable plug plate 9 is movably inserted into the bottom end of the rotating sleeve 8. A first spring 10 is fixedly connected between the upper end of the movable plug plate 9 and the rotating sleeve 8, and shielding frames 11 are fixedly connected to the two opposite sides of the upper surface of the supporting platform 6, and the shielding frame 11 is located between the rotating sleeve 8 and the placement box 3.

[0041] Specifically, the shielding frame 11 is provided to facilitate the rats to run into the placement box 3 and to prevent the rats from running out of the feeding box 1. The rotating sleeve plate 8 and the movable plug plate 9 are provided to prevent the movable plug plate 9 from colliding with the supporting platform 6 when driving away the rats, thereby preventing a gap from being left between the movable plug plate 9 and the supporting platform 6 to squeeze the rats.

[0042] In another embodiment provided by the present invention, the clamping mechanism 13 includes a connecting sleeve block 136 fixedly connected to the middle part of the bottom end of the lifting arc plate 121, a baffle 133 is provided on the side of the connecting sleeve block 136 away from the feeding box 1, and the baffle 133 is horizontally slidably arranged in the placement box 3, a sixth spring 137 is fixedly connected between the side wall of the bottom end of the baffle 133 and the placement box 3, a trapezoidal groove 138 is provided on the upper end of the connecting sleeve block 136 near the side wall of the baffle 133, the upper end of the baffle 133 is in contact with a connecting slide bar 132, and the connecting slide bar 132 is slidably arranged in the placement box 3 up and down, a fifth spring 134 is fixedly connected between the upper end of the connecting slide bar 132 and the placement box 3, an arc-shaped splint 131 is estimated to be provided on the upper end of the connecting slide bar 132 near the side wall of the feeding box 1, and the arc-shaped splint 131 is slidably arranged on the inner wall of the placement box 3 up and down, and a pulling block 135 is fixedly connected to the upper end of the connecting slide bar 132 away from the side wall of the feeding box 1.

[0043] Specifically, after the injection, the trapezoidal limiting rod 15 is pulled outward to rotate the placement box 3 to its original position, the pulling block 135 is pulled upward to release the fixation of the rat, and then the pulling block 135 is shaken several times to drive the rat to move from the placement box 3 to the feeding box 1, and the lifting arc plate 121 is automatically reset.

[0044] In another embodiment provided by the present invention, a rotating shaft 20 is fixedly connected to the bottom end of the placement box 3, and the rotating shaft 20 is rotatably set on the connecting block 4, a fixed connecting block 14 is fixedly connected to the side of the lower surface of the placement box 3 away from the feeding box 1, a limiting opening 19 is provided at the bottom end of the fixed connecting block 14, a slot opening 16 is provided on the side wall of the connecting block 4 away from the feeding box 1, a trapezoidal limiting rod 15 is movably inserted on the upper side of the inner wall of the slot opening 16, and a seventh spring 17 is fixed between the side wall of the trapezoidal limiting rod 15 extending to the outside of the connecting block 4 and the outer wall of the connecting block 4.

[0045] Specifically, by fixing the connecting block 14 and the trapezoidal limiting rod 15 and rotating the placement box 3 to be set on the connecting block 4, the pull rope 126 is continuously pulled out and will not be retracted, thereby preventing the clamping roller 125 from moving back after clamping the tail, causing the rat's tail to bend, making subsequent injections inconvenient.

[0046] In another embodiment provided by the present invention, friction blocks 21 are provided on two opposite sides of the lifting arc plate 121 in the placement box 3 , and the friction blocks 21 are in conflict with the lifting arc plate 121 .

[0047] Specifically, the friction block 21 is provided to prevent the lifting arc plate 121 from moving down too quickly when the rat presses down the lifting arc plate 121, causing the rat to be clamped by the arc clamping plate 131 before being driven away and turning around.

[0048] In another embodiment provided by the present invention, a plurality of toggle rods 1221 are arranged at equal intervals, and the toggle rods 1221 and the toggle blocks 1222 are both located on a side of the rotating rod 1212 away from the breeding box 1.

[0049] The thickness of the toggle block 1222 is equal to that of the sliding rod 122 , the thickness of the toggle rod 1221 is half of the thickness of the sliding rod 122 , and the toggle rod 1221 is disposed close to the winding roller 127 .

[0050] Specifically, when the rotary rod 1212 is close to the toggle rod 1221, the toggle rod 1221 will squeeze the rotary rod 1212, so that the rotation angle of the rotary rod 1212 is an acute angle, thereby preventing the clamping roller 125 from clamping the rat's tail multiple times when clamping is not needed, causing the rat to be subjected to excessive stimulation and affecting subsequent treatment. It can also prevent the clamping rollers 125 on both sides from excessively conflicting and affecting the service life of the second spring 1213. When the rotary rod 1212 moves to the toggle block 1222, the rotary rod 1212 rotates ninety degrees to fully clamp the tail.

[0051] Working principle: When the rat needs to be taken out for injection treatment, the lifting component 7 is started, and the carrying platform 6 is moved upward by the lifting component 7. The shielding frame 11 is moved upward by the push of the carrying platform 6. The notch at the connection between the placement box 3 and the feeding box 1 coincides with the notch on the shielding frame 11, which is convenient for the rat to run into the placement box 3. When the shielding frame 11 is located on the lower side, it can also prevent the rat from running out of the feeding box 1. The shielding frame 11 moves upward to squeeze the upper end of the rotating sleeve 8, so that the two rotating sleeves 8 rotate in a direction away from each other. When the upper surface of the carrying platform 6 contacts the bottom end of the movable plug plate 9, the movable plug plate 9 is pressed inward while the rotating sleeve 8 rotates, so that the rotating sleeve 8 and the movable plug plate 9 contact the carrying platform 6 when driving away the rat, preventing There is a gap between the movable plug plate 9 and the supporting platform 6, which squeezes the rat. Then the rat is driven into the placement box 3 by the movable plug plate 9. When the rat enters the placement box 3, due to its own gravity, the rat will squeeze the lifting arc plate 121 downward, and then the bottom end of the lifting arc plate 121 squeezes the sliding rod 122, so that the sliding rod 122 moves toward the direction close to the feeding box 1, and the multiple toggle rods 1221 squeeze the rotating rod 1212 in turn, so that the rotating rod 1212 rotates, thereby rotating the rotating plates 123 on both sides, and the rotation of the rotating plates 123 and the clamping rollers 125 will further drive the rat, so that the rat curls up to a position away from the feeding box 1, and the rat's head can be directed to the side away from the feeding box 1, which can also prevent the rat from being placed. The rat can escape from the placement box 3. When the lifting arc plate 121 continues to move downward, the elastic blocking frame 133 will be pressed into the trapezoidal groove 138, and then the other end of the blocking frame 133 will move away from the connecting slide bar 132. The connecting slide bar 132 will suddenly move downward through the elastic force of the fifth spring 134, and the bottom end of the arc clamping plate 131 can be clamped on the rat instantly, so that the rat's body is fixed. Then the placement box 3 is rotated clockwise. Due to the rotation of the placement box 3, the pull rope 126 will be pulled out, and the pull rope 126 drives the winding roller 127 to rotate clockwise. Through the transmission of the winding roller 127, the gear 129, the spur rack 1210 and the sliding block 1211, the sliding block 1211 moves toward the side close to the lifting arc plate 121. When the rotating rod 1212 moves to the sliding rod When the rat is at position 122, the sliding rod 122 squeezes the rotating rod 1212, so that the clamping rollers 125 on both sides initially contact the rat's hips, and then the rotating plate 123 continues to rotate, so that the clamping rollers 125 on both sides can gradually contact the rat's tail, clamping the rat's tail while also straightening the rat's tail, which is more convenient for subsequent tail injection. After rotating the placement box 3 by 90 degrees, the fixed connecting block 14 is inserted into the slot opening 16, and the trapezoidal limiting rod 15 is also bounced into the limiting opening 19, so that the fixed connecting block 14 and the placement box 3 are fixed. After the injection is completed, the trapezoidal limiting rod 15 is pulled outward to rotate the placement box 3 to its original position, and the pulling block 135 is pulled upward to release the fixation of the rat, and then the pulling block 135 is shaken several times.The rats are driven from the placement box 3 to the feeding box 1 to complete the treatment.

[0052] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and the description in the specification are only to illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A positioning device for interventional treatment of a rat animal model, comprising a feeding box (1) and a switch door (2) arranged on the feeding box (1), characterized in that: The two opposite outer walls of the feeding box (1) are fixedly connected with connecting blocks (4), a placement box (3) is provided on the connecting blocks (4), a driving mechanism (12) and a clamping mechanism (13) are provided in the placement box (3), counterweight blocks (5) are fixedly connected to the two opposite outer walls of one end of the placement box (3) close to the feeding box (1), a bearing platform (6) is provided in the inner cavity of the feeding box (1) for sliding up and down, a lifting component (7) is fixedly connected between the lower surface of the bearing platform (6) and the inner wall of the feeding box (1), and a rotating sleeve (8) is rotatably provided on the upper side of the bearing platform (6) which is located on the inner wall of the feeding box (1); The driving mechanism (12) comprises a lifting arc plate (121) which is slidably arranged on the lower surface of the inner cavity of the placement box (3) up and down, and the lifting arc plate (121) is arranged away from the feeding box (1), and two opposite positions on the lower side of the lifting arc plate (121) are located in the placement box (3) and are provided with sliding rods (122), and the sliding rods (122) are horizontally slidably arranged in the placement box (3), and the two opposite sides of the bottom end of the lifting arc plate (121) are slidably arranged on sliding rods (122). A fourth spring (1217) is fixedly connected between the bottom end of the lifting arc plate (121) and the placement box (3) on the rod (122), a toggle rod (1221) and a toggle block (1222) are provided at the upper end of the sliding rod (122), and the toggle block (1222) is arranged close to the lifting arc plate (121), and a winding roller (127) is rotatably arranged at the bottom end of the placement box (3) close to the feeding box (1), and the outer wall of the middle part of the winding roller (127) is wound around A pull rope (126) is connected, and the other end of the pull rope (126) is fixedly connected to the outer wall of the feeding box (1), both ends of the winding roller (127) are fixedly connected to gears (129) rotatably arranged in the placement box (3), a first torsion spring (128) is fixedly connected between the outer walls of both ends of the winding roller (127) and the placement box (3), and a spur rack (1210) is meshedly connected to the upper side of the gear (129), and the spur rack (1210) is slidably arranged on the placement box (3). Inside the box (3), a sliding block (1211) is fixedly connected to the upper end of the spur rack (1210), and the sliding block (1211) is horizontally slidably arranged on the inner wall of the placement box (3), a central axis (1214) is rotatably arranged inside the sliding block (1211), one end of the central axis (1214) extending to the lower side of the sliding block (1211) is fixedly connected to a rotating rod (1212), and the upper end of the central axis (1214) is fixedly connected to a rotating plate (123); A second torsion spring (18) is fixedly connected between the outer wall of one end of the central rotating shaft of the rotating sleeve (8) and the feeding box (1); two rotating sleeves (8) are provided, and the two rotating sleeves (8) are respectively close to the placement boxes (3) arranged on both sides; a movable plug plate (9) is movably inserted at the bottom end of the rotating sleeve (8); a first spring (10) is fixedly connected between the upper end of the movable plug plate (9) and the rotating sleeve (8); shielding frames (11) are fixedly connected to the two opposite sides of the upper surface of the bearing platform (6), and the shielding frame (11) is located between the rotating sleeve (8) and the placement box (3); A plug-in frame (124) is movably plugged into the lower side of one end of the rotating plate (123) away from the feeding box (1), and a second spring (1213) is fixedly connected between one end of the plug-in frame (124) located inside the rotating plate (123) and the rotating plate (123), a clamping roller (125) is rotatably provided on one end of the plug-in frame (124) extending outside the rotating plate (123), a fixed block (1215) is fixedly connected inside the sliding block (1211), and a third spring (1216) is fixedly connected between one end of the central axis (1214) and the fixed block (1215); The clamping mechanism (13) comprises a connecting sleeve (136) fixedly connected to the middle part of the bottom end of the lifting arc plate (121); a retaining frame (133) is provided on the side of the connecting sleeve (136) away from the feeding box (1); and the retaining frame (133) is horizontally slidably arranged in the placement box (3); a sixth spring (137) is fixedly connected between the side wall of the bottom end of the retaining frame (133) and the placement box (3); a trapezoidal groove (138) is provided on the side wall of the upper end of the connecting sleeve (136) close to the retaining frame (133); and the retaining frame (133) is provided with a plurality of springs (137) and a plurality of springs (138) are provided on the side wall of the upper end of the connecting sleeve (136) and close to the retaining frame (133); ) has an upper end that abuts against a connecting slide bar (132), and the connecting slide bar (132) is slidably arranged in the placement box (3) up and down, a fifth spring (134) is fixedly connected between the upper end of the connecting slide bar (132) and the placement box (3), an arc-shaped clamping plate (131) is fixedly connected to the upper end of the connecting slide bar (132) near the side wall of the feeding box (1), and the arc-shaped clamping plate (131) is slidably arranged on the inner wall of the placement box (3) up and down, and a pulling block (135) is fixedly connected to the upper end of the connecting slide bar (132) away from the side wall of the feeding box (1); A plurality of the toggle rods (1221) are arranged at equal intervals, and the toggle rods (1221) and the toggle blocks (1222) are both located on a side of the rotating rod (1212) away from the feeding box (1); The thickness of the toggle block (1222) is equal to the thickness of the sliding rod (122), the thickness of the toggle rod (1221) is half the thickness of the sliding rod (122), and the toggle rod (1221) is arranged close to the winding roller (127); When the rotating sleeve (8) rotates, the movable plug plate (9) is pressed inward, so that when the rotating sleeve (8) and the movable plug plate (9) drive the rat, the movable plug plate (9) and the bearing platform (6) collide with each other, thereby preventing a gap from being left between the movable plug plate (9) and the bearing platform (6) to squeeze the rat. After that, the rat is driven into the placement box (3) by the movable plug plate (9). When the rat enters the placement box (3), due to its own gravity, the rat pushes the lifting arc plate (121) downward. After squeezing, the bottom end of the lifting arc plate (121) squeezes the sliding rod (122), causing the sliding rod (122) to move toward the feeding box (1), and the plurality of toggle rods (1221) sequentially squeeze the rotating rod (1212), causing the rotating rod (1212) to rotate, thereby causing the rotating plates (123) on both sides to rotate. The rotation of the rotating plates (123) and the clamping rollers (125) further drive the rats away from the feeding box (1). The rat is curled up in a position and its head is directed toward a side away from the feeding box (1) to prevent the rat from escaping from the placing box (3). The placing box (3) is rotated clockwise. As the placing box (3) rotates, the pull rope (126) is pulled out. The pull rope (126) drives the winding roller (127) to rotate clockwise. The transmission of the winding roller (127), the gear (129), the spur rack (1210) and the sliding block (1211) causes the sliding block (1211) to rotate clockwise. ) moves toward a side close to the lifting arc plate (121), and when the rotating rod (1212) moves to the toggle block (1222), the toggle block (1222) squeezes the rotating rod (1212), so that the clamping rollers (125) on both sides initially contact the rat's buttocks, and then the rotating plate (123) continues to rotate, so that the clamping rollers (125) on both sides can gradually contact the rat's tail, clamping the rat's tail while also straightening the rat's tail.

2. The rat animal model interventional treatment positioning device according to claim 1, characterized in that: The bottom end of the placement box (3) is fixedly connected with a rotating shaft (20), and the rotating shaft (20) is rotatably arranged on the connecting block (4); a fixed connecting block (14) is fixedly connected to the side of the lower surface of the placement box (3) away from the feeding box (1); a limiting opening (19) is provided at the bottom end of the fixed connecting block (14); a slot opening (16) is provided on the side wall of the connecting block (4) away from the feeding box (1); a trapezoidal limiting rod (15) is movably inserted on the upper side of the inner wall of the slot opening (16); a seventh spring (17) is fixedly connected between the side wall of one end of the trapezoidal limiting rod (15) extending outside the connecting block (4) and the outer wall of the connecting block (4).

3. The rat animal model interventional treatment positioning device according to claim 1, characterized in that: Friction blocks (21) are provided on two opposite sides of the lifting arc plate (121) in the placement box (3), and the friction blocks (21) are in contact with the lifting arc plate (121).

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