A production process and equipment for oseltamivir pharmaceutical granules

Abstract

The present invention discloses a production process and equipment of oseltamivir pharmaceutical granules, which belong to the field of medicinal material processing equipment. It mainly includes a double-layer screening mechanism, a driving motor 2 is fixedly connected to the bottom center of the double-layer screening mechanism, a supporting leg is fixedly connected to the outer side of the bottom of the double-layer screening mechanism, a spiral lifting mechanism is provided in the center of the double-layer screening mechanism, a shaking drying mechanism is provided on the top of the double-layer screening mechanism, a supporting frame is fixedly connected to the outer side of the top of the double-layer screening mechanism, a stirring granulation mechanism is fixedly connected to the top of the supporting frame, a driving motor 1 is provided on the top of the stirring granulation mechanism, and a shaking component is provided on one side of the stirring granulation mechanism. The present invention screens out the particles with larger volume due to adhesion and the particles with smaller volume due to crushing in the pharmaceutical granules by setting a double-layer screening mechanism, and crushes them, which greatly guarantees the size specification effect of the pharmaceutical granules. The present invention is mainly used to produce oseltamivir pharmaceutical granules.

Description

Technical Field

[0001] The present invention belongs to the field of medicinal material processing equipment, and in particular, relates to an oseltamivir pharmaceutical granule production process and equipment thereof. Background Art

[0002] With the continuous development of society and the continuous progress of the medical industry, various types of medicinal drugs are continuously produced, and granular drugs account for a large proportion. Therefore, there are many types of granular drug manufacturing devices on the market today, which can basically meet people's needs.

[0003] A Chinese patent with authorization announcement number "CN113797096B" discloses a granular medicine manufacturing machine, including a shell, a stirring chamber and a molding chamber are provided in the shell, a stirring mechanism and an extrusion mechanism are installed in the stirring chamber, a molding mechanism for making the stirred medicine into a granular medicine is installed in the molding chamber, and a driving mechanism is also installed outside the shell, the driving mechanism is used to drive the molding mechanism, the stirring mechanism and the extrusion mechanism, by opening the drop hole, the medicine is fed to the lower part of the extrusion disk, and then the upper and lower parts of the stirring chamber are isolated by closing the drop hole, so that the extrusion disk moves down to discharge the material while the stirring mechanism can stir the next batch of medicines to improve production efficiency.

[0004] In the later use process, the device still has the following problems: it is unable to quickly dry the newly granulated pharmaceutical particles, and it is unable to effectively fix the shape of the pharmaceutical particles, resulting in irregular molding of the pharmaceutical particles. Summary of the invention

[0005] The technical problem to be solved by the present invention is: to overcome the shortcomings of the prior art and provide an oseltamivir pharmaceutical granule production process and equipment, which screens out the pharmaceutical granules that are larger in volume due to adhesion and the particles that are smaller in volume due to crushing by setting a double-layer screening mechanism, and crushes them, thereby greatly ensuring the size specification effect of the pharmaceutical granules.

[0006] The oseltamivir pharmaceutical granule production equipment comprises a double-layer screening mechanism, a discharge pipe opening is fixedly provided at the front of the double-layer screening mechanism, a baffle plate is slidably connected to the discharge pipe opening, a hot air component is fixedly provided at the rear of the double-layer screening mechanism, a second drive motor is fixedly connected to the center of the bottom of the double-layer screening mechanism, a support leg is fixedly connected to the outer side of the bottom of the double-layer screening mechanism, a spiral lifting mechanism is provided at the center of the double-layer screening mechanism, a shaking and drying mechanism is provided at the top of the double-layer screening mechanism, a support frame is fixedly connected to the outer side of the top of the double-layer screening mechanism, a stirring and granulating mechanism is fixedly connected to the top of the support frame, a driving motor is provided at the top of the stirring and granulating mechanism, a shaking component is provided on one side of the stirring and granulating mechanism, and the shaking component cooperates with the shaking and drying mechanism.

[0007] Preferably, the stirring and granulating mechanism comprises a stirring chamber and a granulating chamber, the stirring chamber is located at the top of the granulating chamber, the top of the stirring chamber is fixedly connected with a fixing frame, the top of the fixing frame is fixedly connected with a driving motor 1, the output shaft of the driving motor 1 extends downward into the stirring chamber, a feeding port is provided on the outer side of the top of the stirring chamber, a mounting rod frame is fixedly connected to the outer wall of the stirring chamber, a driving shaft is rotatably connected inside the stirring chamber, the top of the driving shaft is fixedly connected with the output shaft of the driving motor 1, a stirring spiral rod and a pushing plate are fixedly connected to the outer wall of the driving shaft, and a pushing plate is provided on the outer wall of the driving shaft. The material plate is located at the bottom of the stirring spiral rod, a fixed partition is fixedly provided at the bottom of the stirring bin, a dynamic partition is rotatably connected to the lower part of the driving shaft, the dynamic partition cooperates with the fixed partition, the driving shaft extends downward into the granulating bin, a ratchet drum is rotatably connected to the center of the granulating bin, the ratchet drum cooperates with the driving shaft, a plurality of groups of extruding blades are fixedly connected to the outer wall of the ratchet drum, the extruding blades cooperate with the inner side wall of the granulating bin, a granulating hole is fixedly opened on the side wall of the granulating bin, a scraper is fixedly connected to the bottom of the ratchet drum, the scraper cooperates with the outer side wall of the granulating bin.

[0008] Preferably, the upper portion of the driving shaft is fixedly provided with a material lifting outlet, the top inner wall of the driving shaft is fixedly provided with a one-way driving gear ring, the lower outer wall of the driving shaft is fixedly provided with multiple groups of hole grooves and an installation groove one, the installation groove one is located at the bottom of the hole groove, a movable tooth plate one is rotatably connected to the installation groove one, a compression spring one is fixedly connected to the inner side of the movable tooth plate one, the other end of the compression spring one is fixedly connected to the installation groove one, the movable tooth plate one cooperates with the ratchet rotating cylinder, a limiting block one is fixedly connected to the outer side of the movable partition plate, the limiting block one cooperates with the side wall of the fixed partition plate, a mounting hole is provided on the inner wall of the movable partition plate, a compression spring two is fixedly connected to the bottom of the mounting hole, the other end of the compression spring two is fixedly connected to a limiting pin, the limiting pin is slidably connected to the mounting hole, and the limiting pin cooperates with the hole groove.

[0009] Preferably, the shaking and drying mechanism includes an outer cylinder, a fixed shaft is fixedly provided on the outer side of the top of the outer cylinder, the inner side of the top of the outer cylinder is rotatably connected to the outer wall of the mixing bin, a plurality of sets of air outlet inclined plates are fixedly connected to the bottom of the outer cylinder, an inner cylinder is fixedly connected to the inside of the outer cylinder, a ventilation hole is fixedly opened on the top of the inner cylinder, a plurality of sets of material receiving plates are fixedly connected to the inner wall of the inner cylinder, the plurality of sets of material receiving plates are spirally arranged, the material receiving plates are hollow structures, the material receiving plates extend outward from the inner cylinder, and an inclined plug plate is fixedly provided on the material receiving plates.

[0010] Preferably, the shaking assembly includes a connecting shaft, a pulley 1 and a swing rod, the connecting shaft is rotatably connected to the mounting rod frame, a pulley 2 is fixedly connected to the top of the connecting shaft, the pulley 2 is adaptably connected to a belt, the belt is also adaptably connected to the pulley 1, the pulley 1 is fixedly connected to the output shaft of the driving motor 1, a turntable is fixedly connected to the bottom of the connecting shaft, a fixed shaft 2 is fixedly provided at the bottom of the turntable, a rotating hole is fixedly opened on one side of the swing rod, the rotating hole is rotatably connected to the outer wall of the mixing bin, an axis groove 2 is fixedly opened on the other side of the swing rod, the axis groove 2 is slidably connected to the fixed shaft 2, an axis groove 1 is fixedly opened in the middle of the swing rod, the axis groove 1 is slidably connected to the fixed shaft 1.

[0011] Preferably, the double-layer screening mechanism includes a material gathering base, a rotating groove is fixedly opened in the center of the material gathering base, a fixed crushing wheel is fixedly arranged on the top of the material gathering base, a fixed cylinder is fixedly connected to the outer side of the top of the material gathering base, a plurality of discharge ports are fixedly arranged on the side wall of the fixed cylinder, the top of the fixed cylinder is rotatably connected to the bottom of the inner cylinder, a silo is fixedly connected to the outer wall of the fixed cylinder, a discharge pipe port is provided at the front of the silo, a hot air component is provided at the rear of the silo, a turning ring is fixedly connected to the inner wall of the fixed cylinder, the turning ring includes an upper guide turning ring and a lower guide turning ring, a screening recovery turntable is rotatably connected to the material gathering base, and the top center of the screening recovery turntable is fixedly connected to the top of the silo. A feeding hole is fixedly provided, a coarse material sieve plate is arranged on the top of the screening and recovery turntable, the coarse material sieve plate is matched with the upper guide turning ring, a fine material sieve plate is arranged at the bottom of the coarse material sieve plate, the fine material sieve plate is matched with the lower guide turning ring, a sparse material layer is fixedly arranged at the bottom of the fine material sieve plate, a ring groove is arranged at the bottom of the sparse material layer, a gathering material layer is arranged at the bottom of the ring groove, a rotating seat is arranged at the bottom of the gathering material layer, the rotating seat matches with the rotating groove, a crushing tooth ring is slidably connected in the ring groove, the crushing tooth ring matches with the fixed crushing wheel disc, the crushing tooth ring includes helical teeth, a limit block two is fixedly arranged on the helical teeth, a compression spring three is fixedly connected to the top of the helical teeth, and the other end of the compression spring three is fixedly connected to the annular groove.

[0012] Preferably, the spiral lifting mechanism includes an outer lifting cylinder, a lifting screw is arranged inside the outer lifting cylinder, a lifting inlet is fixedly opened at the bottom of the outer lifting cylinder, the bottom of the outer lifting cylinder is fixedly connected to the center of the top of the rotating seat, the outer wall of the outer lifting cylinder is rotatably connected to the inner wall of the center of the receiving plate, the upper outer wall of the outer lifting cylinder is rotatably connected to the inner wall of the driving shaft, the diameter of the outer lifting cylinder is smaller than the diameter of the feeding hole, the top of the outer lifting cylinder is lower than the lifting outlet, a mounting groove 2 is fixedly opened on the top of the lifting screw, a movable tooth plate 2 is rotatably connected to the mounting groove 2, a compression spring 4 is fixedly connected to the inner side of the movable tooth plate 2, the other end of the compression spring 4 is fixedly connected to the mounting groove 2, and the movable tooth plate 2 cooperates with the one-way drive gear ring.

[0013] Preferably, the hot air assembly includes a driving motor three and a heating plate, and a fan is fixedly connected to the output shaft of the driving motor three.

[0014] Preferably, a process for producing oseltamivir pharmaceutical granules comprises the following steps:

[0015] a: Put the raw material of oseltamivir medicine into the feed port, start the driving motor 1, and make the driving motor 1 rotate forward, and the raw material of oseltamivir medicine is stirred under the push of the stirring screw rod and the push plate, so that the raw materials of each component are fully mixed;

[0016] b: The driving motor is rotated in the reverse direction, and the raw material of oseltamivir enters the granulation bin, is squeezed by the extrusion blade, squeezed out from the granulation hole and scraped by the scraper, thereby completing the granulation operation;

[0017] c: The oseltamivir granules fall into the receiving tray, and the hot air component is started to dry the oseltamivir granules in the inner cylinder. The shaking drying mechanism is repeatedly shaken under the drive of the shaking component, so that the oseltamivir granules are continuously turned over and fall to the next layer of the receiving tray, further accelerating the drying speed of the oseltamivir granules and ensuring the drying effect;

[0018] d: Start the second drive motor, and the screening and recovery turntable performs two screening operations on the oseltamivir pharmaceutical particles, removing the particles with larger volume due to mutual adhesion and the particles with smaller volume due to crushing, and push the particles with unqualified volume back into the mixing bin through the spiral lifting mechanism for reprocessing;

[0019] e: Oseltamivir pharmaceutical granules that meet the volume requirements enter the silo from the discharge port and are finally discharged from the discharge pipe port, completing the production of Oseltamivir pharmaceutical granules.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] 1. By setting up a double-layer screening mechanism, the particles with larger volume due to adhesion and the particles with smaller volume due to crushing are screened out and crushed, which greatly ensures the size specification effect of the pharmaceutical particles;

[0022] 2. By setting up a shaking drying mechanism, the granulated pharmaceutical particles can be dried, and the repeated shaking can cause the pharmaceutical particles to continuously turn and roll in the receiving tray, ensuring that the pharmaceutical particles can be dried evenly, ensuring the drying effect of the particles, and avoiding the adhesion of the pharmaceutical particles;

[0023] 3. By setting up a stirring and granulating mechanism, the pharmaceutical raw materials can be fully stirred by driving the motor forward. At the same time, the forward rotation of the motor can close the dynamic partition to prevent the material from entering the granulation bin in advance. The granulation operation of the pharmaceutical raw materials can also be completed by driving the motor in the reverse direction. At the same time, the dynamic partition is opened to allow the evenly stirred material to enter the granulation bin. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the overall structure of the front part of the present invention;

[0025] Figure 2 It is a schematic diagram of the overall structure of the rear part of the present invention;

[0026] Figure 3 It is a schematic diagram of the internal structure of the present invention;

[0027] Figure 4 It is a structural schematic diagram of the stirring granulation mechanism;

[0028] Figure 5It is a schematic diagram of the internal structure of the stirring and granulating mechanism;

[0029] Figure 6 is a schematic diagram of the structure of the driving shaft;

[0030] Figure 7 It is a schematic diagram of the internal structure of the moving partition and the ratchet drum;

[0031] Figure 8 It is a structural schematic diagram of the shaking drying mechanism;

[0032] Fig. 9 It is a schematic diagram of the internal structure of the shaking drying mechanism;

[0033] Fig.10 It is a schematic diagram of the structure of the inner cylinder and the receiving tray;

[0034] Fig.11 It is a structural schematic diagram of the receiving tray;

[0035] Fig.12 It is a structural schematic diagram of the shaking component;

[0036] Fig.13 is a schematic diagram of the structure of the swing rod;

[0037] Fig.14 It is a structural schematic diagram of a double-layer screening mechanism and a spiral lifting mechanism;

[0038] Fig.15 It is a schematic diagram of the internal structure of the double-layer screening mechanism;

[0039] Fig.16 It is a schematic diagram of the structure of the upper guide turning ring and the lower guide turning ring;

[0040] Fig.17 It is a schematic diagram of the structure of the screening recovery turntable and the aggregate base;

[0041] Fig.18 It is a schematic diagram of the internal structure of the screening recovery turntable and the aggregate base;

[0042] Fig.19 It is a structural schematic diagram of the aggregate base;

[0043] Fig. 20 It is a structural schematic diagram of the screening and recovery turntable;

[0044] Fig.21 It is a schematic diagram of the internal structure of the screening and recovery turntable;

[0045] Fig. 22 It is a schematic diagram of the structure of the crushing gear ring;

[0046] Fig.23 It is a schematic diagram of part of the internal structure of the spiral lifting mechanism;

[0047] Fig.24 It is a structural schematic diagram of the spiral lifting mechanism and the driving shaft;

[0048] Fig.25 It is a schematic diagram of part of the internal structure of the spiral lifting mechanism and the driving shaft.

[0049] In the figure, 1, stirring and granulating mechanism; 101, stirring chamber; 102, feeding port; 103, fixed frame; 104, mounting rod frame; 105, granulating chamber; 105A, granulating hole; 106, scraper; 107, driving shaft; 107A, material lifting outlet; 107B, stirring screw rod; 107C, pushing plate; 107D, one-way driving gear ring; 107E, hole slot; 107F, compression spring 1; 107G, movable tooth plate 1; 107H, mounting slot 1; 108, fixed partition; 109, movable partition; 109A, limit block 1; 109B, mounting hole; 109C, compression spring 2; 109D, limit pin; 110, ratchet drum; 111, extruding paddle; 2, shaking drying mechanism; 201, outer drum; 201A, fixed axis 1; 202, air outlet inclined plate; 203, inner drum; 203A, ventilation hole; 204, receiving plate; 204A, inclined plug plate; 3, double-layer screening mechanism; 301, discharge pipe; 301A, baffle plate; 302, supporting leg; 303, hot air assembly; 303A, driving motor 3; 303B, fan; 303C, heating plate; 304, silo; 305, screening and recovery turntable; 305A, feeding hole; 305B, coarse material sieve plate; 305C, fine material sieve plate; 305D, thin material layer; 305E, ring groove; 305F, gathering material layer; 305G, rotating seat; 306, turning ring; 306A, upper guide turning ring; 306B, lower guide turning ring; 307, fixed cylinder; 307A, discharge port; 308, gathering base; 308A, fixed crushing wheel; 308B, rotating groove; 309, crushing gear ring; 309A, compression spring three; 309B, limit block 2; 309C, oblique teeth; 4, shaking assembly; 401, pulley one; 402, belt; 403, pulley two; 404, connecting shaft; 405, turntable; 405A, fixed shaft two; 406, swing rod; 406A, rotating hole; 406B, shaft slot one; 406C, shaft slot two; 5, driving motor one; 6, supporting frame; 7, spiral lifting mechanism; 701, lifting outer cylinder; 701A, lifting inlet; 702, lifting screw; 702A, mounting slot two; 703, movable tooth plate two; 704, compression spring four; 8, driving motor two. DETAILED DESCRIPTION

[0050] The present invention will be further described below in conjunction with the accompanying drawings:

[0051] The directional nouns involved in the detailed description paragraphs are only for the convenience of those skilled in the art to understand the technical solutions described in this application according to the visual orientation shown in the accompanying drawings. Unless otherwise clearly specified and limited, the terms "setting", "installation", "connection", etc. should be understood in a broad sense. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0052] like Figure 1 , Figure 2 and Figure 3 As shown, an oseltamivir pharmaceutical granule production device comprises a double-layer screening mechanism 3, a discharge nozzle 301 is fixedly arranged at the front of the double-layer screening mechanism 3, a baffle plate 301A is slidably connected to the discharge nozzle 301, and a hot air component 303 is fixedly arranged at the rear of the double-layer screening mechanism 3. By setting the double-layer screening mechanism 3, the particles with larger volume due to adhesion and the particles with smaller volume due to crushing in the pharmaceutical granules are screened out and crushed, which greatly ensures the size specification effect of the pharmaceutical granules; a driving motor 8 is fixedly connected to the bottom center of the double-layer screening mechanism 3, and the double-layer screening mechanism 3 is fixedly provided with a discharge nozzle 301, and a baffle plate 301A is slidably connected to the discharge nozzle 301, and a hot air component 303 is fixedly arranged at the rear of the double-layer screening mechanism 3. A support leg 302 is fixedly connected to the outer side of the bottom of the sub-mechanism 3, and a spiral lifting mechanism 7 is provided in the center of the double-layer screening mechanism 3. By setting the spiral lifting mechanism 7, the crushed material can be lifted to the stirring and granulating mechanism 1 for reuse; a shaking drying mechanism 2 is provided on the top of the double-layer screening mechanism 3. By setting the shaking drying mechanism 2, the granulated pharmaceutical particles can be dried, and the pharmaceutical particles can be repeatedly turned and rolled in the receiving plate 204 by repeated shaking, so as to ensure that the pharmaceutical particles can be dried evenly, ensure the drying effect of the particles, and avoid the adhesion of the pharmaceutical particles.

[0053] The top outer side of the double-layer screening mechanism 3 is fixedly connected with a support frame 6, and the top of the support frame 6 is fixedly connected with a stirring and granulating mechanism 1. By setting the stirring and granulating mechanism 1, the pharmaceutical raw materials can be fully stirred by driving the motor 5 in the forward direction, and the motor can close the movable partition 109 when it is in the forward direction to prevent the material from entering the granulating bin 105 in advance. The pharmaceutical raw materials can also be granulated by driving the motor 5 in the reverse direction, and the movable partition 109 can be opened at the same time to allow the stirred materials to enter the granulating bin 105. A driving motor 5 is provided on the top of the stirring and granulating mechanism 1, and a shaking component 4 is provided on one side of the stirring and granulating mechanism 1. By setting the shaking component 4, the rotational motion of the driving motor 5 can be converted into a repeated swinging motion, so that the shaking and drying mechanism 2 is repeatedly shaken; the shaking component 4 cooperates with the shaking and drying mechanism 2.

[0054] like Figure 4 and Figure 5As shown, the stirring and granulating mechanism 1 includes a stirring chamber 101 and a granulating chamber 105, the stirring chamber 101 is located at the top of the granulating chamber 105, the top of the stirring chamber 101 is fixedly connected with a fixing frame 103, the top of the fixing frame 103 is fixedly connected to a driving motor 5, the output shaft of the driving motor 5 extends downward into the stirring chamber 101, a feeding port 102 is provided on the outer side of the top of the stirring chamber 101, a mounting rod frame 104 is fixedly connected to the outer wall of the stirring chamber 101, a driving shaft 107 is rotatably connected inside the stirring chamber 101, the top of the driving shaft 107 is fixedly connected to the output shaft of the driving motor 5, and the outer wall of the driving shaft 107 is fixedly connected with a stirring screw 10 7B and a push plate 107C, the push plate 107C is located at the bottom of the stirring screw 107B, a fixed partition 108 is fixedly provided at the bottom of the stirring chamber 101, and a movable partition 109 is rotatably connected to the lower part of the driving shaft 107, the movable partition 109 cooperates with the fixed partition 108, when the movable partition 109 is opened by rotation, the movable partition 109 and the fixed partition 108 overlap, and the pharmaceutical raw materials in the stirring chamber 101 can enter the granulating chamber 105, when the movable partition 109 is closed under the drive of the driving shaft 107, the movable partition 109 and the fixed partition 108 jointly completely seal the bottom of the stirring chamber 101, so that the stirring chamber 101 and the granulating chamber 105 are separated.

[0055] The driving shaft 107 extends downward into the granulating bin 105, and the ratchet drum 110 is rotatably connected to the center of the granulating bin 105. The ratchet drum 110 cooperates with the driving shaft 107. When the driving shaft 107 rotates forward, the ratchet drum 110 cannot be driven. At this time, only the stirring bin 101 is working, and the granulating bin 105 stops working; when the driving shaft 107 rotates reversely, the ratchet drum 110 starts to rotate. At this time, both the stirring bin 101 and the granulating bin 105 start to work; the ratchet drum A plurality of extrusion blades 111 are fixedly connected to the outer wall of 110. The extrusion blades 111 cooperate with the inner side wall of the granulation bin 105 to squeeze the evenly stirred pharmaceutical raw materials toward the side wall of the granulation bin 105. The pharmaceutical raw materials are squeezed out from the granulation hole 105A and are scraped by the scraper 106 to become granules. A granulation hole 105A is fixedly opened on the side wall of the granulation bin 105, and a scraper 106 is fixedly connected to the bottom of the ratchet drum 110, and the scraper 106 cooperates with the outer side wall of the granulation bin 105.

[0056] like Figure 6 and Figure 7As shown, a material lifting outlet 107A is fixedly provided on the upper portion of the driving shaft 107, a one-way driving gear ring 107D is fixedly provided on the inner wall of the top of the driving shaft 107, a plurality of groups of hole grooves 107E and a mounting groove 107H are fixedly provided on the outer wall of the lower portion of the driving shaft 107, the mounting groove 107H is located at the bottom of the hole groove 107E, a movable tooth plate 107G is rotatably connected to the mounting groove 107H, a compression spring 107F is fixedly connected to the inner side of the movable tooth plate 107G, the other end of the compression spring 107F is fixedly connected to the mounting groove 107H, the movable tooth plate 107H cooperates with the ratchet drum 110, and the movable tooth plate 107G is rotatably connected to the ratchet drum 110. Under the elastic force of the compression spring 107F, 107H maintains a tendency to open outward and can always contact the inner wall of the ratchet drum 110. A one-way tooth groove is also fixedly provided on the inner wall of the ratchet drum 110, which can contact and cooperate with the movable tooth plate 107H. When the driving shaft 107 rotates forward, the movable tooth plate 107H can slide and cooperate with the one-way tooth groove, and cannot effectively transmit power to the ratchet drum 110. When the driving shaft 107 rotates reversely, the movable tooth plate 107H is fixedly contacted with the one-way tooth groove, and can transmit all power to the ratchet drum 110, driving the scraper 106 and the extrusion paddle 111 to rotate.

[0057] The outer side of the movable partition 109 is fixedly connected to a limiting block 109A, and the limiting block 109A cooperates with the side wall of the fixed partition 108. By setting the limiting block 109A, the movable partition 109 can be prevented from rotating at an angle that is too large or too small, and cannot accurately cooperate with the fixed partition 108 to open or close the channel between the mixing bin 101 and the granulating bin 105; a mounting hole 109B is opened on the inner wall of the movable partition 109, and a compression spring 109C is fixedly connected to the bottom of the mounting hole 109B, and the other end of the compression spring 109C is fixedly connected to a limiting pin 109D, and the limiting pin 109D is slidably connected to the mounting hole 109B, and the limiting pin 109D cooperates with the hole groove 107E, the hole groove 107E is a hemispherical groove, and the end of the limiting pin 109D is a spherical protrusion. Under the elastic force of the compression spring 109C, the limit pin 109D maintains contact with the hole groove 107E. Therefore, the rotational power of the driving shaft 107 can be transmitted to the movable partition 109 through the limit pin 109D, driving the movable partition 109 to completely overlap with the fixed partition 108 to open the passage between the mixing chamber 101 and the granulating chamber 105, or driving the movable partition 109 to cooperate with the fixed partition 108 to completely seal the passage between the mixing chamber 101 and the granulating chamber 105; when the movable partition 109 is rotated into place, it will not be able to continue to rotate due to the limit of the limit block 109A. At this time, the driving shaft 107 continues to rotate, which will push the limit pin 109D out of the hole groove 107E, and the power between the driving shaft 107 and the movable partition 109 is interrupted.

[0058] like Figure 8 , Fig. 9 , Fig.10and Fig.11 As shown, the shaking and drying mechanism 2 includes an outer cylinder 201, a fixed shaft 201A is fixedly provided on the outer side of the top of the outer cylinder 201, the inner side of the top of the outer cylinder 201 is rotatably connected to the outer wall of the mixing chamber 101, a plurality of sets of air outlet inclined plates 202 are fixedly connected to the bottom of the outer cylinder 201, an inner cylinder 203 is fixedly connected inside the outer cylinder 201, a ventilation hole 203A is fixedly opened on the top of the inner cylinder 203, a plurality of sets of material receiving plates 204 are fixedly connected to the inner wall of the inner cylinder 203, the plurality of sets of material receiving plates 204 are spirally arranged, the material receiving plates 204 are hollow structures, the material receiving plates 204 extend outward from the inner cylinder 203, and an inclined plug plate 204A is fixedly provided on the material receiving plates 204. After the pharmaceutical particles fall into the receiving tray 204, they continue to move forward under the combined action of shaking and tilting the insert plate 204A. After moving a certain distance, they will fall into the next layer of the receiving tray 204 under the action of gravity, and will be dried by hot air during this process. The pharmaceutical particles are constantly turned over so that they can be dried evenly to avoid the situation where the surface particles are over-dried and the bottom particles are still wet, thereby ensuring the drying effect. Although the moisture entrained in the dried hot air is not suitable for continuing to dry the pharmaceutical particles, the heat therein can be reused. Therefore, the hot air after the drying operation flows into the interlayer between the outer cylinder 201 and the inner cylinder 203 from the ventilation hole 203A. The heat in the hot air can be conducted through the inner cylinder 203 and the hollow structure of the receiving tray 204 to continue to heat and dry the pharmaceutical materials. The hot air is finally discharged from the air outlet inclined plate 202.

[0059] like Fig.12 and Fig.13 As shown, the shaking assembly 4 includes a connecting shaft 404, a pulley 401 and a swing rod 406, the connecting shaft 404 is rotatably connected to the mounting rod frame 104, the top of the connecting shaft 404 is fixedly connected to a pulley 403, the pulley 403 is adaptably connected to a belt 402, the belt 402 is also adaptably connected to the pulley 401, the pulley 401 is fixedly connected to the output shaft of the driving motor 5, the bottom of the connecting shaft 404 is fixedly connected to a turntable 405, the bottom of the turntable 405 is fixedly provided with a fixed shaft 2 405A, a rotating hole 406A is fixedly opened on one side of the swing rod 406, the rotating hole 406A is rotatably connected to the outer wall of the mixing chamber 101, the other side of the swing rod 406 is fixedly opened with an axis groove 2 406C, the axis groove 2 406C is slidably connected to the fixed axis 2 405A, the middle of the swing rod 406 is fixedly opened with an axis groove 1 406B, and the axis groove 1 406B is slidably connected to the fixed axis 1 201A. The rotation of the driving motor 5 is transmitted through the belt 402 and the connecting shaft 404, so that the turntable 405 rotates, and the fixed shaft 2 405A drives the swing rod 406 to swing repeatedly and quickly, and the swing rod 406 transmits the swinging action to the shaking and drying mechanism 2 through the fixed shaft 1 201A.

[0060] like Fig.17 , Fig.18 , Fig.19 , Fig. 20 and Fig.21 As shown, the double-layer screening mechanism 3 includes a material gathering base 308, a rotating groove 308B is fixedly opened in the center of the material gathering base 308, a fixed crushing wheel 308A is fixedly arranged on the top of the material gathering base 308, a fixed cylinder 307 is fixedly connected to the outer side of the top of the material gathering base 308, a plurality of groups of discharge ports 307A are fixedly arranged on the side wall of the fixed cylinder 307, the top of the fixed cylinder 307 is rotatably connected to the bottom of the inner cylinder 203, a silo 304 is fixedly connected to the outer wall of the fixed cylinder 307, a discharge pipe port 301 is provided at the front of the silo 304, a hot air assembly 303 is provided at the rear of the silo 304, and a turning ring 306 is fixedly connected to the inner wall of the fixed cylinder 307, as shown in FIG. Fig.16 As shown, the material turning ring 306 includes an upper guide material turning ring 306A and a lower guide material turning ring 306B, and a screening recovery turntable 305 is rotatably connected to the material gathering base 308. A feeding hole 305A is fixedly provided at the top center of the screening recovery turntable 305. Under the screening action of the coarse material sieve plate 305B, pharmaceutical particles with too large a volume cannot pass through the coarse material sieve plate 305B, and can only be pushed to the feeding hole 305A by the upper guide material turning ring 306A and fall into the thin material layer 305D.

[0061] A coarse material sieve plate 305B is provided on the top of the screening and recovery turntable 305, and the coarse material sieve plate 305B cooperates with the upper guide turning ring 306A. A fine material sieve plate 305C is provided at the bottom of the coarse material sieve plate 305B. Under the screening action of the fine material sieve plate 305C, the pharmaceutical particles with too small volume pass through the sieve holes and fall into the material thinning layer 305D, while the pharmaceutical particles that meet the volume size requirements fall into the silo 304 from the discharge port 307A under the push of the lower guide turning ring 306B; the fine material sieve plate 305C cooperates with the lower guide turning ring 306B, and a material thinning layer 305D is fixedly provided at the bottom of the fine material sieve plate 305C, and a ring groove 305E is provided at the bottom of the material thinning layer 305D, and a material gathering layer 305F is provided at the bottom of the ring groove 305E A rotating seat 305G is provided at the bottom of the aggregation layer 305F, and the rotating seat 305G cooperates with the rotating groove 308B. After the oversized or undersized pharmaceutical particles fall into the thinning layer 305D, they fall into the interlayer between the screening recovery turntable 305 and the aggregation base 308 under the action of centrifugal force and gravity, and continue to slide down along the interlayer space, fall into the bottom center of the aggregation base 308, gather in the aggregation layer 305F, and enter the material lifting outer cylinder 701 through the material lifting inlet 701A, and return to the mixing bin 101 again under the action of the spiral lifting mechanism 7, and the pharmaceutical particles are recycled again; a crushing tooth ring 309 is slidably connected in the annular groove 305E, and the crushing tooth ring 309 cooperates with the fixed crushing wheel 308A, such as Fig. 22As shown, the crushing tooth ring 309 includes a beveled tooth 309C, on which a second stopper 309B is fixed, through which the beveled tooth 309C and the screening and recovery turntable 305 can be kept circumferentially fixed; a compression spring 309A is fixedly connected to the top of the beveled tooth 309C, and the other end of the compression spring 309A is fixedly connected to the annular groove 305E. The pharmaceutical particles in the interlayer between the screening and recovery turntable 305 and the aggregate base 308 are crushed by the beveled tooth 309C and the fixed crushing wheel 308A during the falling process, which is convenient for the subsequent mixing of the pharmaceutical particles with the pharmaceutical raw materials.

[0062] like Fig.14 , Fig.23 , Fig.24 and Fig.25 As shown, the spiral lifting mechanism 7 includes a material lifting outer cylinder 701, a material lifting screw 702 is arranged inside the material lifting outer cylinder 701, a material lifting inlet 701A is fixedly opened at the bottom of the material lifting outer cylinder 701, the bottom of the material lifting outer cylinder 701 is fixedly connected to the top center of the rotating seat 305G, the outer wall of the material lifting outer cylinder 701 is rotatably connected to the inner wall of the center of the material receiving plate 204, the upper outer wall of the material lifting outer cylinder 701 is rotatably connected to the inner wall of the driving shaft 107, and the straightness of the material lifting outer cylinder 701 is rotatably connected to the inner wall of the driving shaft 107. The diameter is smaller than the diameter of the feeding hole 305A, the top of the lifting outer cylinder 701 is lower than the lifting outlet 107A, and a mounting groove 2 702A is fixedly opened on the top of the lifting screw 702. A movable tooth plate 2 703 is rotatably connected to the mounting groove 2 702A, and a compression spring 4 704 is fixedly connected to the inner side of the movable tooth plate 2 703. The other end of the compression spring 4 704 is fixedly connected to the mounting groove 2 702A, and the movable tooth plate 2 703 cooperates with the one-way drive gear ring 107D. The movable tooth plate 2 703 remains open under the elastic force of the compression spring 4 704, so that the movable tooth plate 2 703 is always in contact with the one-way drive gear ring 107D. When the drive shaft 107 rotates in the forward direction, the movable tooth plate 2 703 is in fixed contact with the one-way drive gear ring 107D, and the power of the drive shaft 107 can be effectively transmitted to the lifting screw 702, thereby lifting the crushed pharmaceutical particles from the bottom of the aggregation base 308 to the mixing chamber 101; when the drive shaft 107 rotates in the reverse direction, the movable tooth plate 2 703 is in sliding contact with the one-way drive gear ring 107D, and the lifting screw 702 stops rotating.

[0063] like Fig.15 As shown, the hot air assembly 303 includes a driving motor 303A and a heating plate 303C, and a fan 303B is fixedly connected to the output shaft of the driving motor 303A.

[0064] A process for producing oseltamivir pharmaceutical granules comprises the following steps:

[0065] a: The raw material of oseltamivir medicine is put into the feed port 102, and the drive motor 5 is started and rotated forward. The raw material of oseltamivir medicine is stirred under the push of the stirring screw 107B and the push plate 107C, so that the raw materials of each component are fully mixed;

[0066] b: The driving motor 5 is rotated in the reverse direction, and the oseltamivir pharmaceutical raw material enters the granulation bin 105, is squeezed by the extrusion blade 111, is squeezed out from the granulation hole 105A and is scraped by the scraper 106, thereby completing the granulation operation;

[0067] c: The oseltamivir granules fall into the receiving tray 204, and the hot air component 303 is started to dry the oseltamivir granules in the inner cylinder 203. The shaking and drying mechanism 2 is repeatedly shaken under the drive of the shaking component 4, so that the oseltamivir granules are continuously turned over and fall to the next layer of the receiving tray 204, further accelerating the drying speed of the oseltamivir granules and ensuring the drying effect;

[0068] d: Start the drive motor 2 8, and the screening and recovery turntable 305 performs two screening operations on the oseltamivir pharmaceutical particles, removes the particles with larger volume due to mutual adhesion and the particles with smaller volume due to crushing, and pushes the particles with unqualified volume back into the mixing chamber 101 through the spiral lifting mechanism 7 for reprocessing;

[0069] e: The oseltamivir pharmaceutical granules with the required volume enter the silo 304 from the discharge port 307A, and are finally discharged from the discharge pipe port 301, completing the production of the oseltamivir pharmaceutical granules.

[0070] Working principle:

[0071] 1. Start and rotate the drive motor 5 forward, the stirring screw 107B stirs the medicine raw materials, the spiral lifting mechanism 7 lifts the medicine particles that need to be recycled after crushing to the stirring bin 101, stirs them together, and the movable partition 109 is closed;

[0072] 2. Reverse the drive motor 15, the movable partition 109 opens, the stirring screw 107B pushes the pharmaceutical raw materials into the granulation bin 105, the spiral lifting mechanism 7 stops rotating, the extruding blade 111 and the scraper 106 rotate, and the granulation operation is carried out;

[0073] 3. Start the hot air component 303 to dry the medicine particles in the shaking and drying mechanism 2. The shaking component 4 drives the shaking and drying mechanism 2 to shake repeatedly, so that the medicine particles are constantly turned over and rolled down, thereby ensuring the drying effect and accelerating the drying speed;

[0074] 4. The medicine particles fall into the coarse material sieve plate 305B to screen out the medicine particles with too large volume size, and the medicine particles fall into the fine material sieve plate 305C to screen out the medicine particles with too small volume size. The medicine particles with too large or too small volume size first fall into the thin material layer 305D, and then fall into the interlayer between the screening recovery turntable 305 and the gathering base 308 under the action of centrifugal force. After being crushed by the fixed crushing wheel 308A and the crushing gear ring 309, they enter the gathering layer 305F and are recycled through the spiral lifting mechanism 7;

[0075] 5. The pharmaceutical particles that meet the requirements enter the silo 304 from the discharge port 307A, completing the production of the pharmaceutical particles.

[0076] The present invention sets up a double-layer screening mechanism 3 to screen out the particles with larger volume due to adhesion and the particles with smaller volume due to crushing in the pharmaceutical particles, and crushes them, thereby greatly ensuring the size specification effect of the pharmaceutical particles; by setting up a shaking and drying mechanism 2, the granulated pharmaceutical particles can be dried, and the pharmaceutical particles are caused to continuously flip and roll in the receiving plate 204 by repeated shaking, thereby ensuring that the pharmaceutical particles can be dried evenly, ensuring the drying effect of the particles, and avoiding the adhesion of the pharmaceutical particles; by setting up a stirring and granulating mechanism 1, the pharmaceutical raw materials can be fully stirred by driving the motor 5 in the forward direction, and the forward rotation of the motor can close the dynamic partition 109 to prevent the material from entering the granulating bin 105 in advance, and the granulation operation of the pharmaceutical raw materials can also be completed by driving the motor 5 in the reverse direction, and the dynamic partition 109 can be opened at the same time to allow the stirred material to enter the granulating bin 105.

Claims

1. An oseltamivir pharmaceutical granule production device, characterized in that: The double-layer screening mechanism (3) comprises a double-layer screening mechanism (3), wherein a discharge pipe opening (301) is fixedly provided at the front of the double-layer screening mechanism (3), a baffle plate (301A) is slidably connected to the discharge pipe opening (301), a hot air component (303) is fixedly provided at the rear of the double-layer screening mechanism (3), a second drive motor (8) is fixedly connected at the center of the bottom of the double-layer screening mechanism (3), a support leg (302) is fixedly connected at the outer side of the bottom of the double-layer screening mechanism (3), a spiral lifting mechanism (7) is provided at the center of the double-layer screening mechanism (3), a shaking drying mechanism (2) is provided at the top of the double-layer screening mechanism (3), a support frame (6) is fixedly connected at the outer side of the top of the double-layer screening mechanism (3), a stirring and granulating mechanism (1) is fixedly connected at the top of the support frame (6), a driving motor (5) is provided at the top of the stirring and granulating mechanism (1), a shaking component (4) is provided at one side of the stirring and granulating mechanism (1), and the shaking component (4) cooperates with the shaking and drying mechanism (2); The stirring and granulating mechanism (1) comprises a stirring chamber (101) and a granulating chamber (105); the stirring chamber (101) is located at the top of the granulating chamber (105); a fixing frame (103) is fixedly connected to the top of the stirring chamber (101); the top of the fixing frame (103) is fixedly connected to a driving motor (5); the output shaft of the driving motor (5) extends downward into the stirring chamber (101); a feeding port (102) is provided on the outer side of the top of the stirring chamber (101); a mounting rod frame (104) is fixedly connected to the outer wall of the stirring chamber (101); a driving shaft (107) is rotatably connected inside the stirring chamber (101); the top of the driving shaft (107) is fixedly connected to the output shaft of the driving motor (5); the outer wall of the driving shaft (107) is fixedly connected to a stirring screw rod (107B) and a pushing plate (107C); the pushing plate (107C) is located at the stirring chamber (101). A fixed partition (108) is fixedly provided at the bottom of the screw rod (107B) and the bottom of the stirring bin (101); a movable partition (109) is rotatably connected to the lower part of the driving shaft (107); the movable partition (109) cooperates with the fixed partition (108); the driving shaft (107) extends downward into the granulating bin (105); a ratchet rotating drum (110) is rotatably connected to the center of the granulating bin (105); the ratchet rotating drum (110) cooperates with the driving shaft (107); a plurality of groups of extruding blades (111) are fixedly connected to the outer wall of the ratchet rotating drum (110); the extruding blades (111) cooperate with the inner side wall of the granulating bin (105); a granulating hole (105A) is fixedly opened on the side wall of the granulating bin (105); a scraper (106) is fixedly connected to the bottom of the ratchet rotating drum (110); the scraper (106) cooperates with the outer side wall of the granulating bin (105); The upper portion of the driving shaft (107) is fixedly provided with a material lifting outlet (107A), the top inner wall of the driving shaft (107) is fixedly provided with a one-way driving gear ring (107D), the lower outer wall of the driving shaft (107) is fixedly provided with a plurality of groups of hole grooves (107E) and a mounting groove 1 (107H), the mounting groove 1 (107H) is located at the bottom of the hole groove (107E), a movable tooth plate 1 (107G) is rotatably connected to the mounting groove 1 (107H), the inner side of the movable tooth plate 1 (107G) is fixedly connected with a compression spring 1 (107F), the other end of the compression spring 1 (107F) is fixedly connected to the mounting groove 1 (107H), and the other end of the compression spring 1 (107F) is fixedly connected to the mounting groove 1 (107H). The movable tooth plate (107G) is matched with the ratchet rotating cylinder (110), the outer side of the movable partition (109) is fixedly connected to the limiting block (109A), the limiting block (109A) is matched with the side wall of the fixed partition (108), the inner wall of the movable partition (109) is provided with a mounting hole (109B), the bottom of the mounting hole (109B) is fixedly connected with a compression spring (109C), the other end of the compression spring (109C) is fixedly connected with a limiting pin (109D), the limiting pin (109D) is slidably connected with the mounting hole (109B), and the limiting pin (109D) is matched with the hole groove (107E); The spiral lifting mechanism (7) comprises a material lifting outer cylinder (701), a material lifting screw (702) is arranged inside the material lifting outer cylinder (701), a material lifting inlet (701A) is fixedly opened at the bottom of the material lifting outer cylinder (701), the upper outer wall of the material lifting outer cylinder (701) is rotatably connected to the inner wall of the driving shaft (107), the top of the material lifting outer cylinder (701) is lower than the material lifting outlet (107A), a mounting groove 2 (702A) is fixedly opened at the top of the material lifting screw (702), a movable tooth plate 2 (703) is rotatably connected to the mounting groove 2 (702A), a compression spring 4 (704) is fixedly connected to the inner side of the movable tooth plate 2 (703), the other end of the compression spring 4 (704) is fixedly connected to the mounting groove 2 (702A), and the movable tooth plate 2 (703) cooperates with the one-way driving gear ring (107D).

2. The oseltamivir pharmaceutical granule production equipment according to claim 1, characterized in that: The shaking drying mechanism (2) comprises an outer cylinder (201), a fixed shaft (201A) is fixedly provided on the outer side of the top of the outer cylinder (201), the inner side of the top of the outer cylinder (201) is rotatably connected to the outer wall of the stirring chamber (101), a plurality of groups of air outlet inclined plates (202) are fixedly connected to the bottom of the outer cylinder (201), an inner cylinder (203) is fixedly connected inside the outer cylinder (201), a ventilation hole (203A) is fixedly opened on the top of the inner cylinder (203), a plurality of groups of material receiving plates (204) are fixedly connected to the inner wall of the inner cylinder (203), the plurality of groups of material receiving plates (204) are arranged in a spiral, the material receiving plates (204) are hollow structures, the material receiving plates (204) extend outward from the inner cylinder (203), and an inclined plug plate (204A) is fixedly provided on the material receiving plates (204).

3. The oseltamivir pharmaceutical granule production equipment according to claim 2, characterized in that: The shaking assembly (4) comprises a connecting shaft (404), a pulley 1 (401) and a swing rod (406); the connecting shaft (404) is rotatably connected to the mounting rod frame (104); a pulley 2 (403) is fixedly connected to the top of the connecting shaft (404); the pulley 2 (403) is adaptably connected to a belt (402); the belt (402) is also adaptably connected to the pulley 1 (401); the pulley 1 (401) is fixedly connected to the output shaft of the driving motor 1 (5); and a rotating disk (405) is fixedly connected to the bottom of the connecting shaft (404). ), a second fixed shaft (405A) is fixedly provided at the bottom of the turntable (405), a rotating hole (406A) is fixedly provided on one side of the swing rod (406), the rotating hole (406A) is rotatably connected to the outer wall of the mixing chamber (101), a second shaft groove (406C) is fixedly provided on the other side of the swing rod (406), the second shaft groove (406C) is slidably connected to the second fixed shaft (405A), and a first shaft groove (406B) is fixedly provided in the middle of the swing rod (406), the first shaft groove (406B) is slidably connected to the first fixed shaft (201A).

4. The oseltamivir pharmaceutical granule production equipment according to claim 3, characterized in that: The double-layer screening mechanism (3) comprises a material gathering base (308), a rotating groove (308B) is fixedly provided at the center of the material gathering base (308), a fixed crushing wheel (308A) is fixedly provided at the top of the material gathering base (308), a fixed cylinder (307) is fixedly connected to the outer side of the top of the material gathering base (308), a plurality of groups of discharge ports (307A) are fixedly provided on the side wall of the fixed cylinder (307), the top of the fixed cylinder (307) is rotatably connected to the bottom of the inner cylinder (203), and the outer wall of the fixed cylinder (307) is fixedly connected to the material bin (3 04), the front of the silo (304) is a discharge pipe (301), the rear of the silo (304) is a hot air assembly (303), a material turning ring (306) is fixedly connected to the inner wall of the fixed cylinder (307), the material turning ring (306) includes an upper guide material turning ring (306A) and a lower guide material turning ring (306B), a screening and recovery turntable (305) is rotatably connected to the material gathering base (308), a material passing hole (305A) is fixedly provided at the top center of the screening and recovery turntable (305), and the top of the screening and recovery turntable (305) is A coarse material sieve plate (305B) is provided, the coarse material sieve plate (305B) cooperates with an upper guide turning ring (306A), a fine material sieve plate (305C) is provided at the bottom of the coarse material sieve plate (305B), the fine material sieve plate (305C) cooperates with a lower guide turning ring (306B), a thin material layer (305D) is fixedly provided at the bottom of the fine material sieve plate (305C), a ring groove (305E) is provided at the bottom of the thin material layer (305D), a gathering material layer (305F) is provided at the bottom of the ring groove (305E), and a A rotating seat (305G) is matched with a rotating groove (308B), a crushing tooth ring (309) is slidably connected in the annular groove (305E), the crushing tooth ring (309) is matched with a fixed crushing wheel (308A), the crushing tooth ring (309) comprises a helical tooth (309C), a second limit block (309B) is fixedly provided on the helical tooth (309C), a compression spring (309A) is fixedly connected to the top of the helical tooth (309C), and the other end of the compression spring (309A) is fixedly connected to the annular groove (305E).

5. The oseltamivir pharmaceutical granule production equipment according to claim 4, characterized in that: The bottom of the material lifting outer cylinder (701) is fixedly connected to the center of the top of the rotating seat (305G), the outer wall of the material lifting outer cylinder (701) is rotatably connected to the central inner wall of the receiving plate (204), and the diameter of the material lifting outer cylinder (701) is smaller than the diameter of the material passing hole (305A).

6. The oseltamivir pharmaceutical granule production equipment according to claim 5, characterized in that: The hot air component (303) comprises a third drive motor (303A) and a heating plate (303C), and a fan (303B) is fixedly connected to the output shaft of the third drive motor (303A).

7. The production process of an oseltamivir pharmaceutical granule production device according to claim 6, comprising the following steps: a: The raw material of oseltamivir medicine is fed into the feed port (102), and the drive motor 1 (5) is started and rotated forward. The raw material of oseltamivir medicine is stirred under the push of the stirring screw (107B) and the push plate (107C), so that the raw materials of each component are fully mixed; b: driving the driving motor 1 (5) to rotate in the reverse direction, so that the oseltamivir pharmaceutical raw material enters the granulation bin (105), is squeezed by the extrusion blade (111), is squeezed out from the granulation hole (105A) and is scraped by the scraper (106), thereby completing the granulation operation; c: The oseltamivir granules fall into the receiving tray (204), and the hot air component (303) is started to dry the oseltamivir granules in the inner cylinder (203). The shaking drying mechanism (2) is repeatedly shaken under the drive of the shaking component (4), so that the oseltamivir granules are continuously turned over and fall to the next layer of the receiving tray (204), thereby further accelerating the drying speed of the oseltamivir granules and ensuring the drying effect; d: starting the second drive motor (8), and the screening and recovery turntable (305) performs two screening operations on the oseltamivir pharmaceutical particles, removing particles that are larger in size due to mutual adhesion and particles that are smaller in size due to crushing, and pushing particles that do not meet the volume requirements back into the mixing chamber (101) through the spiral lifting mechanism (7) for further processing; e: Oseltamivir pharmaceutical granules with a volume that meets the requirements enter the silo (304) from the discharge port (307A) and are finally discharged from the discharge pipe port (301), completing the production of the oseltamivir pharmaceutical granules.

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