Method and system for monitoring the correlation between anesthetic blood concentration and gas measurement value

Abstract

The present invention discloses a method and system for monitoring the association delay between anesthetic blood drug concentration and gas measurement value, including the following steps: constructing an exhalation detection system; obtaining the gas drug concentration of each exhalation in sequence according to the exhalation frequency; converting the gas drug concentration of each exhalation into a gas measurement value one by one according to the conversion correlation coefficient; obtaining the blood drug concentration values ​​of several groups of blood samples through ion migration spectrometry analysis; selecting at least two groups of gas measurement value segments with unidirectional changes and all the blood drug concentration values ​​corresponding to the time axis segments in which they are located, and subtracting the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment to obtain the numerical association delay time difference. The method solves the technical problem that the gas measurement values ​​of the real-time exhaled gas and the blood drug concentration values ​​detected by the current plasma have time corresponding differences in the prior art, which makes it difficult to accurately obtain the real-time blood drug concentration by conversion without adding the time synchronization coefficient.

Description

Technical Field

[0001] The present invention relates to the technical field of anesthetic blood drug concentration detection, and in particular to a method and system for monitoring the correlation delay between anesthetic blood drug concentration and gas measurement value. Background Art

[0002] At present, medical intravenous anesthetics such as propofol are widely used for induction and maintenance of anesthesia during surgery due to their excellent performance in rapid induction and elimination, short duration of effect, mild recovery after anesthesia, few side effects, and no teratogenic effects. Propofol is volatile and can be metabolized through the respiratory system, that is, propofol directly derived from the blood in the lungs can be detected in the exhaled air.

[0003] Existing studies have shown that there is a certain correlation between the propofol concentration in exhaled gas and the propofol concentration in plasma. Therefore, the gas measurement value obtained by combining the gas drug concentration detected by exhaled gas with the correlation coefficient can reflect the corresponding propofol blood drug concentration value in plasma to a certain extent, thereby realizing non-invasive monitoring.

[0004] However, since the blood has an established conduction process, there is a lag effect in the time correspondence between the real-time gas measurement values ​​of the exhaled gas and the corresponding blood drug concentration values ​​detected in the current plasma, so that it is difficult to accurately obtain the real-time blood drug concentration through conversion of the gas measurement values ​​that are not time-synchronized, and it is difficult to accurately and timely adjust the intravenous infusion dose and speed of propofol, and it is difficult to achieve the expected depth of anesthesia and sedation. Summary of the invention

[0005] To this end, the present invention provides a method and system for monitoring the correlation between anesthetic blood drug concentration and gas measurement values, so as to solve the technical problem in the prior art that there is a time correspondence difference between the real-time gas measurement values ​​of exhaled gas and the blood drug concentration values ​​detected in the current plasma, which makes it difficult to accurately obtain the real-time blood drug concentration through conversion of the gas measurement values ​​without adding the time synchronization coefficient, thereby affecting the infusion dosage.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A method for monitoring the correlation between anesthetic blood concentration and gas measurement value, comprising the following steps:

[0008] Construct a breath detection system that collects exhaled gas quantitatively and obtains gas-drug concentration synchronously according to the respiratory frequency cycle;

[0009] According to the constructed exhalation detection system, the concentration of the gas-drug in each exhalation is obtained in sequence according to the exhalation frequency, and a continuous curve chart of the dynamic change of the gas-drug concentration is established in combination with the time axis;

[0010] Obtaining a conversion correlation coefficient, and converting the gas drug concentration of each exhalation into a gas measurement value for reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph;

[0011] The blood drug concentration values ​​of several groups of blood samples corresponding to the time axis are obtained by ion mobility spectrometry analysis;

[0012] Select at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the corresponding blood drug concentration values ​​obtained in the time axis segment where they are located, subtract the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with equivalent values ​​in the same time axis segment, and take the average of each difference to obtain the value-associated delayed time difference.

[0013] On the basis of the above technical solution, the present invention is further described as follows:

[0014] As a further solution of the present invention, the construction of an exhaled gas detection system for quantitatively collecting exhaled gas and synchronously obtaining the concentration of gas and medicine according to the respiratory frequency cycle specifically includes:

[0015] Establish at least three groups of vacuum chambers, and connect the at least three groups of vacuum chambers to the exhalation masks through pipes respectively. The pipelines corresponding to each group of vacuum chambers are provided with flow sensors and solenoid valves, so as to collect each group of exhaled gas in turn according to the exhalation frequency through the opening and closing control of the solenoid valves, and further combine the flow sensors to keep the collected gas volumes in the at least three groups of vacuum chambers equal;

[0016] Based on the at least three groups of vacuum chambers being further connected to the suction pumps one by one, and the air outlets of the at least three groups of suction pumps being connected to the ventilation drug concentration detection mechanism, the ventilation drug concentration detection mechanism is provided with an exhaust component, so that the internal gas of the at least three groups of vacuum chambers is extracted in turn by the at least three groups of suction pumps for transmission detection and discharge, and each subsequent group of exhaled gas is recollected in turn by the at least three groups of vacuum chambers to realize the exhaled cycle collection and detection.

[0017] As a further solution of the present invention, the exhalation detection system constructed according to the exhalation frequency sequentially obtains the gas drug concentration of each exhalation, and establishes a continuous curve chart corresponding to the dynamic change of the gas drug concentration in combination with the time axis, specifically including:

[0018] The flow path gas volume is monitored respectively by the pipe flow sensors of at least three groups of vacuum chambers, and the pipe solenoid valves of at least three groups of vacuum chambers are controlled to be opened and closed alternately in sequence according to the exhalation frequency and flow monitoring results, so that at least three groups of vacuum chambers collect quantitative and equal amounts of each group of exhaled gas in sequence;

[0019] Afterwards, at least three groups of vacuum pumps are used to sequentially extract the collected gas from at least three groups of vacuum chambers and transmit them to the gas-pharmaceutical concentration detection mechanism, which sequentially outputs the gas-pharmaceutical concentration values ​​corresponding to the at least three groups of vacuum chambers, and the gas-pharmaceutical concentration detection mechanism filters and discharges the collected gas after detection;

[0020] When the collected gas of one group of vacuum chambers is extracted for detection, the vacuum chambers of this group re-collect each subsequent group of exhaled gas, thereby corresponding to at least three groups of vacuum chambers to form an exhaled gas cycle collection and detection;

[0021] Further, according to the gas-pharmaceutical concentration values ​​outputted in sequence by the gas-pharmaceutical concentration detection mechanism and in combination with the time axis information, a continuous curve graph corresponding to the dynamic change of the gas-pharmaceutical concentration is established.

[0022] As a further solution of the present invention, the step of obtaining the conversion correlation coefficient, converting the gas drug concentration of each exhalation into a gas measurement value reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph specifically includes:

[0023] According to different physical signs, breathing frequency and strength, the conversion correlation coefficient between the gas-drug concentration of exhaled gas and its corresponding gas measurement value is obtained;

[0024] The gas-drug concentration values ​​sequentially output by the gas-drug concentration detection mechanism are combined with the converted correlation coefficient to calculate the dynamically changing gas-measured values ​​used to reflect the blood drug concentration, and the dynamically changing gas-measured values ​​are further fitted to the continuous curve graph.

[0025] As a further solution of the present invention, the blood drug concentration values ​​of several groups of blood samples corresponding to the time axis are obtained by ion mobility spectrometry analysis, specifically including:

[0026] Several groups of blood samples are obtained based on the time axis interval corresponding to each group of exhaled gas, and the several groups of blood samples are analyzed in turn by ion mobility spectrometry through a blood drug concentration detection kit to obtain and record the corresponding groups of propofol blood drug concentration values.

[0027] As a further solution of the present invention, the method of selecting at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segment in which they are located, subtracting the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and averaging the differences to obtain the value-related delayed time difference, specifically includes:

[0028] Select at least two groups of gas measurement value segments showing unidirectional changes in the continuous curve graph, and simultaneously select all propofol blood concentration values ​​obtained from the time axis segment where the unidirectionally changing gas measurement value segments are located;

[0029] The gas measurement value that is equivalent to the propofol blood concentration value within a specific threshold range in the same time axis segment is taken as the effective gas measurement value, and the gas measurement time point corresponding to the effective gas measurement value and the blood measurement time point corresponding to the propofol blood concentration value that is in the same time axis segment and has the same value as the effective gas measurement value are recorded separately, the gas measurement time point and the blood measurement time point that are in the same time axis segment and have the same value are subtracted to obtain the single-point delayed time difference, and the average of several groups of single-point delayed time differences is taken to finally obtain the numerically associated delayed time difference.

[0030] A blood drug concentration detection kit for executing the method for monitoring the association between anesthetic blood drug concentration and gas measurement value, the blood drug concentration detection kit comprising a detection base and a calibration product slot, a quality control product slot and a blood sample collection card which are integrally arranged on the detection base; the calibration product slot is used to place a calibration product with a matrix effect, the quality control product slot is used to place a quality control product, and the blood sample collection card is used as a detection carrier for a blood sample or a calibration product or a quality control product in conjunction with an ion mobility spectrometry detection mechanism;

[0031] The calibration product slot and the quality control product slot are both correspondingly provided with temperature control components.

[0032] A correlation delay monitoring system according to the correlation delay monitoring method of the anesthetic blood concentration and the gas measurement value, the correlation delay monitoring system comprises:

[0033] The exhaled gas detection system construction module is used to construct an exhaled gas detection system that collects exhaled gas quantitatively according to the respiratory frequency cycle and simultaneously obtains the concentration of gas and medicine;

[0034] The gas-drug concentration detection module is used to obtain the gas-drug concentration of each exhalation in sequence according to the exhalation frequency according to the constructed exhalation detection system, and to establish a continuous curve chart corresponding to the dynamic change of the gas-drug concentration in combination with the time axis;

[0035] The gas measurement value conversion module is used to obtain the conversion correlation coefficient, and convert the gas drug concentration of each exhalation into a gas measurement value used to reflect the blood drug concentration according to the conversion correlation coefficient, and fit it to a continuous curve graph;

[0036] The blood drug concentration detection module is used to obtain the blood drug concentration values ​​of several groups of blood samples corresponding to the time axis through ion mobility spectrometry analysis;

[0037] The time comparison module is used to select at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segment in which they are located, and to make a difference between the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and to take the average of each difference to obtain the value-related delayed time difference.

[0038] An electronic device comprises: at least one processor, and a memory communicatively connected to the at least one processor, wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor so that the at least one processor can perform the steps of the method.

[0039] A storage medium stores a computer program, which implements the steps of the method when executed by a processor.

[0040] The present invention has the following beneficial effects:

[0041] The method and system can effectively convert the acquired numerical value correlation delay time difference into the gas measurement value of the exhaled gas for time synchronization, and then can obtain more accurate real-time blood drug concentration based on the gas measurement value, thereby achieving more accurate and timely adjustment of the intravenous infusion dosage and speed of propofol, which helps to achieve the expected depth of anesthesia and sedation, and significantly improves the overall functional practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] In order to more clearly illustrate the implementation mode of the present invention or the technical solution in the prior art, the drawings required for the implementation mode or the description of the prior art will be briefly introduced below. The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0043] Figure 1 The present invention provides an overall flow chart of a method for monitoring the association between anesthetic blood drug concentration and gas measurement value provided in an embodiment of the present invention.

[0044] Figure 2 A schematic diagram of the assembly structure of a blood drug concentration detection kit in a method for monitoring the correlation between anesthetic blood drug concentration and gas measurement values ​​provided in an embodiment of the present invention.

[0045] Figure 3 A schematic diagram of the overall architecture of a system for monitoring the correlation between anesthetic blood drug concentration and gas measurement values ​​provided in an embodiment of the present invention.

[0046] Figure 4 is a schematic diagram of the physical structure of an electronic device according to an embodiment of the present invention,

[0047] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0048] Detection base 1, calibration product slot 2, quality control product slot 3, blood sample collection card 4. DETAILED DESCRIPTION

[0049] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0050] The terms such as "upper", "lower", "left", "right", and "middle" used in this specification are only for the convenience of description and are not intended to limit the scope of the invention. Changes or adjustments to their relative relationships should be regarded as within the scope of the invention without substantially changing the technical content.

[0051] like Figure 1 As shown, the embodiment of the present invention provides a method for monitoring the correlation delay between the anesthetic blood concentration and the gas measurement value, which specifically includes the following steps:

[0052] S1: Construct a breath detection system that collects exhaled gas quantitatively and obtains the concentration of gas and medicine synchronously according to the respiratory frequency cycle;

[0053] The specific process is as follows: at least three groups of vacuum chambers are established, and at least three groups of vacuum chambers are connected to the exhalation masks through pipes respectively, and the pipelines corresponding to each group of vacuum chambers are provided with flow sensors and solenoid valves, so as to collect each group of exhaled gas in turn according to the exhalation frequency through the opening and closing control of the solenoid valves, and further the flow sensors are combined to keep the collected gas volumes in the at least three groups of vacuum chambers equal;

[0054] Based on the at least three groups of vacuum chambers being further connected to the suction pumps one by one, and the gas outlets of the at least three groups of suction pumps being connected to the ventilation drug concentration detection mechanism, the gas drug concentration detection mechanism is provided with an exhaust assembly, so that the internal gas of the at least three groups of vacuum chambers is sequentially extracted by the at least three groups of suction pumps for transmission detection and discharge, and each subsequent group of exhaled gas is sequentially recollected by the at least three groups of vacuum chambers, so as to realize the exhaled cycle collection and detection;

[0055] S2: Obtain the concentration of the drug in each breath in sequence according to the exhalation frequency according to the constructed exhalation detection system, and establish a continuous curve graph of the dynamic change of the drug in each breath in combination with the time axis;

[0056] The specific process is: the flow path gas volume is monitored respectively by the flow sensors of at least three groups of vacuum chambers, and the solenoid valves of at least three groups of vacuum chambers are controlled to be opened and closed alternately in sequence according to the exhalation frequency and flow monitoring results, so that at least three groups of vacuum chambers collect quantitative and equal amounts of each group of exhaled gas in sequence;

[0057] Afterwards, at least three groups of vacuum pumps are used to sequentially extract the collected gas from at least three groups of vacuum chambers and transmit them to the gas-pharmaceutical concentration detection mechanism, which sequentially outputs the gas-pharmaceutical concentration values ​​corresponding to the at least three groups of vacuum chambers, and the gas-pharmaceutical concentration detection mechanism filters and discharges the collected gas after detection;

[0058] When the collected gas of one group of vacuum chambers is extracted for detection, the vacuum chambers of this group re-collect each subsequent group of exhaled gas, thereby corresponding to at least three groups of vacuum chambers to form an exhaled gas cycle collection and detection;

[0059] Further, according to the gas-pharmaceutical concentration values ​​outputted in sequence by the gas-pharmaceutical concentration detection mechanism and in combination with the time axis information, a continuous curve graph corresponding to the dynamic change of the gas-pharmaceutical concentration is established;

[0060] S3: obtaining a conversion correlation coefficient, and converting the gas drug concentration of each exhalation into a gas measurement value for reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph;

[0061] The specific process is: according to different physical signs, breathing frequency and strength, the conversion correlation coefficient between the gas-drug concentration of the exhaled gas and its corresponding gas measurement value is obtained;

[0062] The gas-drug concentration values ​​sequentially output by the gas-drug concentration detection mechanism are combined with the converted correlation coefficient to calculate the gas-drug concentration value reflecting the dynamic change of the blood drug concentration, and the dynamically changing gas-drug concentration value is further fitted to the continuous curve graph;

[0063] S4: obtaining blood drug concentration values ​​of several groups of blood samples corresponding to the time axis through ion mobility spectrometry analysis;

[0064] The specific process is: based on the time axis interval corresponding to each group of exhaled gas, several groups of blood samples are obtained, and the several groups of blood samples are analyzed by ion mobility spectrometry through a blood drug concentration detection kit in turn to obtain and record the corresponding several groups of propofol blood drug concentration values;

[0065] Please refer to Figure 2As an optional implementation scheme, the blood drug concentration detection kit includes a detection base 1 and a calibration product slot 2, a quality control product slot 3 and a blood sample collection card 4 which are integrated in the detection base 1, and is used to place a calibration product with a matrix effect through the calibration product slot 2, so as to facilitate the overall operation process of the ion mobility spectrometry detection mechanism. At the same time, the quality control product slot 3 is used to place the quality control product, so as to more conveniently act on the ion mobility spectrometry detection mechanism to achieve the purpose of quality control. In addition, the blood sample collection card 4 can be used as a detection carrier for blood samples or calibration products or quality control products, and further realize the corresponding functions in the ion mobility spectrometry detection mechanism. The overall structure is reasonable and easy to carry, and the calibration products and quality control products do not need to be additionally prepared. The use process is simple, which helps to shorten the detection time and improve the efficiency and accuracy of analysis and detection.

[0066] As a preferred solution of this embodiment, the calibration sample slot 2 and the quality control sample slot 3 are both correspondingly provided with temperature control components to achieve low temperature storage of the calibration sample and the quality control sample.

[0067] S5: selecting at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segment in which they are located, subtracting the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and averaging the differences to obtain the value-related delayed time difference;

[0068] The specific process is: select at least two groups of gas measurement value segments showing unidirectional changes in the continuous curve graph, and simultaneously select all propofol blood drug concentration values ​​obtained from the time axis segment where the unidirectionally changing gas measurement value segments are located;

[0069] The gas measurement value that is equivalent to the propofol blood concentration value within a specific threshold range in the same time axis segment is taken as the effective gas measurement value, and the gas measurement time point corresponding to the effective gas measurement value and the blood measurement time point corresponding to the propofol blood concentration value that is in the same time axis segment and has the same value as the effective gas measurement value are recorded separately, the gas measurement time point and the blood measurement time point that are in the same time axis segment and have the same value are subtracted to obtain the single-point delayed time difference, the average of several groups of single-point delayed time differences is taken, and finally the numerically associated delayed time difference is obtained.

[0070] Please refer to Figure 3 The embodiment of the present invention also provides a system for monitoring the correlation delay between anesthetic blood concentration and gas measurement value, which includes:

[0071] The exhaled gas detection system construction module 10 is used to construct an exhaled gas detection system for quantitatively collecting exhaled gas and synchronously obtaining gas-drug concentration according to the respiratory frequency cycle;

[0072] The gas-drug concentration detection module 20 is used to sequentially obtain the gas-drug concentration of each exhalation according to the exhalation frequency according to the constructed exhalation detection system, and to establish a continuous curve graph corresponding to the dynamic change of the gas-drug concentration in combination with the time axis;

[0073] The gas measurement value conversion module 30 is used to obtain the conversion correlation coefficient, and convert the gas drug concentration of each exhalation into the gas measurement value reflecting the blood drug concentration according to the conversion correlation coefficient, and fit it to a continuous curve graph;

[0074] The blood drug concentration detection module 40 is used to obtain blood drug concentration values ​​of a plurality of groups of blood samples corresponding to the time axis through ion mobility spectrometry analysis;

[0075] The time comparison module 50 is used to select at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segment in which they are located, and to make a difference between the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and to take the average of each difference to obtain the value-related delayed time difference.

[0076] Figure 4 FIG. 1 is a schematic diagram of the physical structure of an electronic device according to an embodiment of the present invention. Figure 4 As shown, the electronic device 90 includes: a processor 901 (processor), a memory 902 (memory) and an internal bus 903;

[0077] The processor 901 and the memory 902 communicate with each other via the internal bus 903;

[0078] The processor 901 is used to call the program instructions in the memory 902 to execute the methods provided by the above-mentioned method embodiments, for example, including: constructing an exhaled gas detection system for cyclically quantitatively collecting exhaled gas and synchronously obtaining gas-drug concentration according to the respiratory frequency; obtaining the gas-drug concentration of each exhalation in sequence according to the exhalation frequency according to the constructed exhaled gas detection system, and establishing a continuous curve graph corresponding to the dynamic change of the gas-drug concentration in combination with the time axis; obtaining a conversion correlation coefficient, and converting the gas-drug concentration of each exhalation into a gas-measured value reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph; obtaining the blood drug concentration values ​​of several groups of blood samples corresponding to the time axis through ion mobility spectrometry analysis; selecting at least two groups of gas-measured value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segments in which they are located, subtracting the time points corresponding to the gas-measured values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and averaging the differences to obtain the value-associated delayed time difference.

[0079] The present embodiment provides a non-transitory computer-readable storage medium, which stores computer instructions. The computer instructions enable a computer to execute the methods provided by the above-mentioned method embodiments, for example, including: constructing an exhaled gas detection system for cyclically quantitatively collecting exhaled gas and synchronously obtaining gas-drug concentration according to the respiratory frequency; sequentially obtaining the gas-drug concentration of each exhalation corresponding to the exhalation frequency according to the constructed exhalation detection system, and establishing a continuous curve graph corresponding to the dynamic change of the gas-drug concentration in combination with the time axis; obtaining a conversion correlation coefficient, and converting the gas-drug concentration of each exhalation into a gas-measured value reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph; obtaining the blood drug concentration values ​​of several groups of blood samples corresponding to the time axis through ion mobility spectrometry analysis; selecting at least two groups of gas-measured value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segments in which they are located, subtracting the time points corresponding to the gas-measured values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and averaging the differences to obtain the value-associated delayed time difference.

[0080] A person skilled in the art can understand that all or part of the steps of implementing the above method embodiment can be completed by hardware related to program instructions, and the aforementioned program can be stored in a computer-readable storage medium. When the program is executed, it executes the steps of the above method embodiment; and the aforementioned storage medium includes: ROM, RAM, magnetic disk or optical disk, etc., various storage media that can store program codes.

[0081] The device embodiments described above are merely illustrative, wherein the units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, i.e., they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Those of ordinary skill in the art may understand and implement it without creative effort.

[0082] Through the description of the above implementation methods, those skilled in the art can clearly understand that each implementation method can be implemented by means of software plus a necessary general hardware platform, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solution is essentially or the part that contributes to the prior art can be embodied in the form of a software product, and the computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a disk, an optical disk, etc., including a number of instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods of each embodiment or some parts of the embodiment.

[0083] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A method for monitoring the delayed correlation between anesthetic blood concentration and gas measurement value, characterized in that: The steps include: Construct a breath detection system that collects exhaled gas quantitatively and obtains gas-drug concentration synchronously according to the respiratory frequency cycle; According to the constructed exhalation detection system, the concentration of the gas-drug in each exhalation is obtained in sequence according to the exhalation frequency, and a continuous curve chart of the dynamic change of the gas-drug concentration is established in combination with the time axis; Obtaining a conversion correlation coefficient, and converting the gas drug concentration of each exhalation into a gas measurement value for reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph; The blood drug concentration values ​​of several groups of blood samples corresponding to the time axis are obtained by ion mobility spectrometry analysis; Select at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the corresponding blood drug concentration values ​​obtained in the time axis segment where they are located, subtract the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with equivalent values ​​in the same time axis segment, and take the average of each difference to obtain the value-associated delayed time difference.

2. The method for monitoring the correlation between anesthetic blood concentration and gas measurement value according to claim 1, characterized in that: The construction of the breath detection system for quantitatively collecting exhaled gas and synchronously obtaining the concentration of gas and medicine according to the respiratory frequency cycle specifically includes: Establish at least three groups of vacuum chambers, and connect the at least three groups of vacuum chambers to the exhalation masks through pipes respectively. The pipelines corresponding to each group of vacuum chambers are provided with flow sensors and solenoid valves, so as to collect each group of exhaled gas in turn according to the exhalation frequency through the opening and closing control of the solenoid valves, and further combine the flow sensors to keep the collected gas volumes in the at least three groups of vacuum chambers equal; Based on the at least three groups of vacuum chambers being further connected to the suction pumps one by one, and the air outlets of the at least three groups of suction pumps being connected to the ventilation drug concentration detection mechanism, the ventilation drug concentration detection mechanism is provided with an exhaust component, so that the internal gas of the at least three groups of vacuum chambers is extracted in turn by the at least three groups of suction pumps for transmission detection and discharge, and each subsequent group of exhaled gas is recollected in turn by the at least three groups of vacuum chambers to realize the exhaled cycle collection and detection.

3. The method for monitoring the correlation between anesthetic blood concentration and gas measurement value according to claim 2, characterized in that: The exhalation detection system constructed according to the above method obtains the gas-drug concentration of each exhalation in sequence according to the exhalation frequency, and establishes a continuous curve chart of the dynamic change of the gas-drug concentration in combination with the time axis, which specifically includes: The flow path gas volume is monitored respectively by the pipe flow sensors of at least three groups of vacuum chambers, and the pipe solenoid valves of at least three groups of vacuum chambers are controlled to be opened and closed alternately in sequence according to the exhalation frequency and flow monitoring results, so that at least three groups of vacuum chambers collect quantitative and equal amounts of each group of exhaled gas in sequence; Afterwards, at least three groups of vacuum pumps are used to sequentially extract the collected gas from at least three groups of vacuum chambers and transmit them to the gas-pharmaceutical concentration detection mechanism, which sequentially outputs the gas-pharmaceutical concentration values ​​corresponding to the at least three groups of vacuum chambers, and the gas-pharmaceutical concentration detection mechanism filters and discharges the collected gas after detection; When the collected gas of one group of vacuum chambers is extracted for detection, the vacuum chambers of this group re-collect each subsequent group of exhaled gas, thereby corresponding to at least three groups of vacuum chambers to form an exhaled gas cycle collection and detection; Further, according to the gas-pharmaceutical concentration values ​​outputted in sequence by the gas-pharmaceutical concentration detection mechanism and in combination with the time axis information, a continuous curve graph corresponding to the dynamic change of the gas-pharmaceutical concentration is established.

4. The method for monitoring the correlation between anesthetic blood concentration and gas measurement value according to claim 3, characterized in that: The step of obtaining the conversion correlation coefficient, converting the gas drug concentration of each exhalation into a gas measurement value for reflecting the blood drug concentration according to the conversion correlation coefficient, and fitting it to a continuous curve graph specifically includes: According to different physical signs, breathing frequency and strength, the conversion correlation coefficient between the gas-drug concentration of exhaled gas and its corresponding gas measurement value is obtained; The gas-drug concentration values ​​sequentially output by the gas-drug concentration detection mechanism are combined with the converted correlation coefficient to calculate the dynamically changing gas-measured values ​​used to reflect the blood drug concentration, and the dynamically changing gas-measured values ​​are further fitted to the continuous curve graph.

5. The method for monitoring the correlation between anesthetic blood concentration and gas measurement value according to claim 4, characterized in that: The method of obtaining blood drug concentration values ​​of a plurality of blood samples corresponding to a time axis by ion mobility spectrometry analysis specifically includes: Several groups of blood samples are obtained based on the time axis interval corresponding to each group of exhaled gas, and the several groups of blood samples are analyzed in turn by ion mobility spectrometry through a blood drug concentration detection kit to obtain and record the corresponding groups of propofol blood drug concentration values.

6. The method for monitoring the correlation between anesthetic blood concentration and gas measurement value according to claim 5, characterized in that: The method of selecting at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segments in which they are located, subtracting the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and averaging the differences to obtain the value-associated delayed time difference specifically includes: Select at least two groups of gas measurement value segments showing unidirectional changes in the continuous curve graph, and simultaneously select all propofol blood concentration values ​​obtained from the time axis segment where the unidirectionally changing gas measurement value segments are located; The gas measurement value that is equivalent to the propofol blood concentration value within a specific threshold range in the same time axis segment is taken as the effective gas measurement value, and the gas measurement time point corresponding to the effective gas measurement value and the blood measurement time point corresponding to the propofol blood concentration value that is in the same time axis segment and has the same value as the effective gas measurement value are recorded separately, the gas measurement time point and the blood measurement time point that are in the same time axis segment and have the same value are subtracted to obtain the single-point delayed time difference, and the average of several groups of single-point delayed time differences is taken to finally obtain the numerically associated delayed time difference.

7. A correlation delay monitoring system according to the correlation delay monitoring method of anesthetic blood concentration and gas measurement value according to claim 6, characterized in that: The associated delay monitoring system comprises: The exhaled gas detection system construction module is used to construct an exhaled gas detection system that collects exhaled gas quantitatively according to the respiratory frequency cycle and simultaneously obtains the concentration of gas and medicine; The gas-drug concentration detection module is used to obtain the gas-drug concentration of each exhalation in sequence according to the exhalation frequency according to the constructed exhalation detection system, and to establish a continuous curve chart corresponding to the dynamic change of the gas-drug concentration in combination with the time axis; The gas measurement value conversion module is used to obtain the conversion correlation coefficient, and convert the gas drug concentration of each exhalation into a gas measurement value used to reflect the blood drug concentration according to the conversion correlation coefficient, and fit it to a continuous curve graph; The blood drug concentration detection module is used to obtain the blood drug concentration values ​​of several groups of blood samples corresponding to the time axis through ion mobility spectrometry analysis; The time comparison module is used to select at least two groups of gas measurement value segments with unidirectional changes in the continuous curve graph and all the blood drug concentration values ​​corresponding to the time axis segment in which they are located, and to make a difference between the time points corresponding to the gas measurement values ​​and blood drug concentration values ​​with the same values ​​in the same time axis segment, and to take the average of each difference to obtain the value-related delayed time difference.

8. An electronic device, comprising: At least one processor, and a memory communicatively connected to the at least one processor, wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to perform the steps of the method described in any one of claims 1 to 6.

9. A storage medium having a computer program stored thereon, characterized in that: When the program is executed by a processor, the steps of the method described in any one of claims 1 to 6 are implemented.

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