Automatic filling device for purification column

Abstract

The present invention belongs to the technical field of separation and purification, and in particular, relates to an automatic filling device for a purification column, including: a liquid storage structure, the liquid storage structure is placed inside a temperature control structure, and the temperature control structure is used to adjust the temperature of the liquid storage structure; a liquid distribution structure, the liquid inlet end of the liquid distribution structure is connected to the liquid outlet end of the liquid storage structure, and the liquid distribution structure is used to control the amount of material added during column loading; a purification column tube rack structure, the purification column tube rack structure is used to place a number of purification columns and load the purification columns, and any one of the purification columns is set corresponding to the liquid outlet end of the liquid distribution structure; a sieve plate filling structure, the sieve plate filling structure is used to load a number of sieve plates, and the outlet ends of the several sieve plates are set corresponding to the feed end of the purification column tube rack structure. The present invention can set parameters of each structure uniformly through software through the automatic control structure, greatly improving the efficiency and accuracy uniformity of purification column loading.

Description

Technical Field

[0001] The invention belongs to the technical field of separation and purification, and in particular relates to an automatic filling device for a purification column. Background Art

[0002] Column purification is a commonly used technology in the separation and purification of substances. In particular, column purification technology based on agarose gel, dextran gel and polymer gel. In column purification analysis technology, gravity column based on gravity is a common form. Gravity column occupies a very important position in the separation process of various substances such as molecular sieve purification and affinity purification due to its advantages such as easy operation and high cost performance.

[0003] The filling of gravity columns is a tedious, time-consuming and laborious task. Some gravity columns are filled by purification technicians themselves during the experimental operation, mainly by manual filling. As gravity columns produced in batches, it is necessary to complete the filling of hundreds or even thousands of gravity purification columns during production, and higher quality requirements are placed on the filling of purification columns. The current purification column filling technology is mainly pure manual or semi-manual, and production personnel need to complete the filling of upper and lower sieve plates, column material filling and other tasks. One disadvantage of manual filling is that the efficiency is very low. In addition, due to manual filling, it is difficult to control the volume of column material filling, which will result in different column material filling amounts and different sieve plate tightness, affecting the purification effect. Summary of the invention

[0004] The purpose of the present invention is to provide an automatic filling device for a purification column to solve the above problems.

[0005] To achieve the above object, the present invention provides the following solutions:

[0006] A purification column automatic filling device, comprising:

[0007] A liquid storage structure, the liquid storage structure is placed inside the temperature control structure, and the liquid storage structure is used to store liquid;

[0008] A liquid distribution structure, wherein the liquid inlet end of the liquid distribution structure is connected to the liquid outlet end of the liquid storage structure, and the liquid distribution structure is used to control the amount of material added during column loading;

[0009] A purification column rack structure, which is used to place a plurality of purification columns and load the purification columns, and any one of the purification columns is arranged corresponding to the liquid outlet end of the liquid distribution structure;

[0010] The sieve plate filling structure is used to fill a plurality of sieve plates, and the discharge ends of the plurality of sieve plates are arranged corresponding to the feed end of the purification column tube rack structure.

[0011] Preferably, the temperature control structure comprises a box body, a partition is fixedly connected inside the box body, the partition divides the box body into two upper and lower cavities, the lower cavity is an installation space, a refrigeration fan is installed inside the installation space, the upper cavity is a refrigeration space, and the liquid storage structure is fixed inside the refrigeration space;

[0012] A refrigeration cavity is formed on the side wall of the refrigeration space. A plurality of refrigeration air plates are installed in the refrigeration cavity. The plurality of refrigeration air plates are evenly and equidistantly distributed. The air inlet end of the refrigeration air plate is connected to the air outlet end of the refrigeration fan.

[0013] Preferably, the liquid storage structure comprises a liquid cylinder, the liquid cylinder is fixedly connected to the inside of the refrigeration space, and the height of the liquid cylinder is consistent with the height of the refrigeration cavity;

[0014] A feeding port is provided on one side of the top of the liquid material cylinder, and a discharge port is provided on the other side, and a stirring structure is provided inside the liquid material cylinder;

[0015] A suction pipe is inserted into the discharge port, a bottom liquid inlet end of the suction pipe extends into the bottom of the liquid cylinder, and a top liquid outlet end of the suction pipe is communicated with a liquid inlet end of the liquid distribution structure.

[0016] Preferably, the stirring structure includes a stirring motor, which is fixedly connected to the middle of the top surface of the liquid cylinder. The output shaft of the stirring motor passes through the top wall of the liquid cylinder and is connected to a stirring shaft. Several groups of stirring paddles are fixedly connected to the outside of the stirring shaft. Each group of stirring paddles includes two stirring paddles symmetrically arranged on the left and right. The several groups of stirring paddles are evenly and equally spaced along the axial direction of the stirring shaft.

[0017] Preferably, a liquid level sensor is fixedly connected to the inner wall of the liquid cylinder, and the liquid level position sensed by the liquid level sensor is higher than the position of the liquid inlet end at the bottom of the suction pipe.

[0018] Preferably, the liquid distribution structure includes a silicone hose, a pump 1, a pump 2, a pump 3, a cleaning liquid bottle, a buffer bottle, a six-way valve, and a waste liquid tank;

[0019] The liquid inlet end of the silicone hose is connected to the liquid outlet end of the suction pipe, the liquid outlet end of the silicone hose is connected to the liquid inlet end of the pump 1, and the liquid outlet end of the pump 1 is connected to the first liquid inlet end of the six-way valve;

[0020] The liquid outlet of the buffer bottle is connected to the liquid inlet of the second pump, and the liquid outlet of the second pump is connected to the second liquid inlet of the six-way valve;

[0021] The liquid outlet of the cleaning liquid bottle is connected to the liquid inlet of the pump 3, and the liquid outlet of the pump 3 is connected to the third liquid inlet of the six-way valve;

[0022] The first liquid outlet end of the six-way valve is communicated with the liquid inlet end of the waste liquid cylinder, and the second liquid outlet end of the six-way valve is communicated with the liquid inlet end of the purification column tube rack structure.

[0023] Preferably, the purification column tube rack structure comprises a liquid outlet hose, the liquid inlet end of the liquid outlet hose is connected to the liquid outlet end of the six-way valve, the liquid outlet hose is clamped on the mechanical arm, the mechanical arm is fixed on the side wall of the chassis, and the chassis is provided with a control panel;

[0024] A driving motor is fixedly connected to the middle of the top surface of the chassis, and the output shaft of the driving motor is axially connected to the purification column tube rack. A plurality of purification column slots are provided on the edge of the purification column tube rack, and the plurality of purification column slots are evenly spaced around the circumference. The liquid outlet end of the liquid outlet hose is arranged corresponding to any one of the purification column slots, and the plurality of purification column slots are used to place the purification columns to be loaded;

[0025] A liquid collecting tray structure is arranged between the purification column tube rack and the bottom plate, and the liquid collecting tray structure is used to collect waste liquid generated during the column packing process.

[0026] Preferably, the liquid collecting tray structure comprises a tray body, a plurality of liquid collecting grooves are provided at the edge of the tray body, the plurality of liquid collecting grooves are equally spaced around the circumference, and the plurality of liquid collecting grooves are arranged in one-to-one correspondence with the plurality of purification column grooves;

[0027] A through hole is opened in the middle of the disk body, and the driving motor is embedded in the through hole.

[0028] Preferably, the robotic arm includes a base, which is fixedly connected to the side wall of the chassis, and a fixed end of a rotating motor is fixedly connected to the middle of the top surface of the base. The output shaft of the rotating motor is connected to an L-shaped bracket, and a clamping hole is opened on the L-shaped bracket, and the liquid outlet hose is nested inside the clamping hole.

[0029] Preferably, the sieve plate filling structure comprises a bracket, the bottom surface of the bracket is symmetrically fixed with two running wheels, the top surface of the bracket is fixed with a support rod, the top end of the support rod is fixed with a material plate, the top surface of the material plate is fixed with a lower material barrel through the bracket, the top surface of the lower material barrel is fixed with a hopper, and the hopper is funnel-shaped;

[0030] The lower barrel is used to hold a plurality of the sieve plates, which are arranged in sequence along the axis direction of the lower barrel, and a gap is left between the bottom surface of the lower barrel and the top surface of the material plate, and the height of the gap is the thickness of one sieve plate;

[0031] A slide groove is provided on the material plate, a fixed end of a push cylinder is fixedly connected inside the slide groove, a movable end of the push cylinder contacts the screen plate, an end of the material plate away from the fixed end of the push cylinder is fixedly connected to a vertical rod, and a fixed end of a linear motor is fixedly connected to the vertical rod;

[0032] The material plate is provided with a sieve plate hole, and the sieve plate hole is connected to any

[0033] A purification column tank is correspondingly arranged.

[0034] Compared with the prior art, the present invention has the following advantages and technical effects:

[0035] 1. The present invention adds a temperature control structure at the bottom of the feed liquid storage structure, which can control the temperature of the feed liquid and is beneficial to the filling of the purification column filler with active ligands.

[0036] 2. The present invention can accurately control the distribution amount through the liquid distribution structure, ensure the accuracy of the feed amount during the column filling process, and avoid mutual contamination between different slurries.

[0037] 3. The present invention can control the stroke of the sieve plate pressing through the sieve plate filling structure, thereby ensuring the accuracy of filling each purification column and the uniformity of the filler column pressure after the sieve plate is pressed. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative labor:

[0039] Figure 1 It is a structural schematic diagram of the present invention;

[0040] Figure 2 It is a schematic diagram of the temperature control structure and the liquid storage structure;

[0041] Figure 3 It is a schematic diagram of the liquid distribution structure;

[0042] Figure 4 It is a structural schematic diagram of the purification column tube rack structure;

[0043] Figure 5 This is an exploded view of the purification column rack structure;

[0044] Figure 6 It is a schematic diagram of the sieve plate filling structure;

[0045] Reference numerals:

[0046] 1. Temperature control structure; 101. Box; 102. Installation space; 103. Refrigeration fan; 104. Partition; 105. Refrigeration cavity; 106. Refrigeration air plate;

[0047] 2. Liquid storage structure; 201. Liquid tank; 202. Stirring structure; 203. Feeding port; 204. Discharging port; 205. Liquid level sensor; 2021. Stirring motor; 2022. Stirring shaft; 2023. Stirring paddle;

[0048] 3. Suction pipe;

[0049] 4. Liquid distribution structure; 401. Silicone hose; 402. Pump 1; 403. Pump 2; 404. Pump 3; 405. Buffer bottle; 406. Cleaning liquid bottle; 407. Six-way valve; 408. Waste liquid tank;

[0050] 5. Purification column tube rack structure; 501. Liquid outlet hose; 502. Control panel; 503. Robotic arm; 504. Chassis; 505. Liquid collecting tray structure; 506. Purification column tube rack; 507. Driving motor; 5051. Tray body; 5052. Liquid collecting tank; 5053. Through hole;

[0051] 6. Screen plate filling structure; 601. Bracket; 602. Travel wheel; 603. Support rod; 604. Material plate; 605. Push cylinder; 606. Unloading barrel; 607. Vertical rod; 608. Linear motor; 609. Screen plate hole. DETAILED DESCRIPTION

[0052] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0053] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0054] Embodiment 1:

[0055] Reference Figures 1 to 6 This embodiment discloses an automatic filling device for a purification column, comprising:

[0056] Temperature control structure 1;

[0057] The liquid storage structure 2 is placed inside the temperature control structure 1 and is used to store liquid. The temperature control structure 1 is used to control the temperature of the liquid storage structure 2, which is beneficial for the filling of the purification column filler with active ligands.

[0058] A liquid distribution structure 4, the liquid inlet end of the liquid distribution structure 4 is connected to the liquid outlet end of the liquid storage structure 2, and the liquid distribution structure 4 is used to control the amount of material added during the column loading process; the liquid distribution structure 4 can accurately control the distribution amount to ensure the accuracy of the amount of material added during the column loading process, and avoid mutual contamination between different slurries;

[0059] A purification column rack structure 5, which is used to place a plurality of purification columns and load the purification columns, and any purification column is arranged corresponding to the liquid outlet end of the liquid distribution structure 4;

[0060] The sieve plate filling structure 6 is used to fill a plurality of sieve plates, and the discharge ends of the plurality of sieve plates are arranged corresponding to the feed end of the purification column tube rack structure 5; the sieve plate pressing stroke can be controlled by the sieve plate filling structure 6 to ensure the accuracy of each purification column filling and the uniformity of the filler column pressure after the sieve plate is pressed;

[0061] The control structure is electrically connected to the temperature control structure 1, the liquid storage structure 2, the liquid distribution structure 4, the purification column rack structure 5, and the sieve plate filling structure 6. Through the automatic control system, the parameters of each module can be uniformly set through the software, which greatly improves the efficiency and accuracy uniformity of the purification column filling.

[0062] Further optimizing the scheme, the temperature control structure 1 includes a box body 101, a partition 104 is fixedly connected inside the box body 101, and the partition 104 divides the box body 101 into two upper and lower cavities. The lower cavity is the installation space 102, and a refrigeration fan 103 is installed inside the installation space 102. The upper cavity is the refrigeration space, and the liquid storage structure 2 is fixed inside the refrigeration space;

[0063] A refrigeration cavity 105 is formed on the side wall of the refrigeration space. A plurality of refrigeration air plates 106 are installed in the refrigeration cavity 105 . The plurality of refrigeration air plates 106 are evenly and equidistantly distributed. The air inlet end of the refrigeration air plate 106 is connected to the air outlet end of the refrigeration fan 103 .

[0064] Further optimizing the solution, the liquid storage structure 2 includes a liquid cylinder 201, the liquid cylinder 201 is fixedly connected to the inside of the refrigeration space, and the height of the liquid cylinder 201 is consistent with the height of the refrigeration chamber 105;

[0065] A feeding port 203 is provided on one side of the top of the liquid material cylinder 201, and a discharge port 204 is provided on the other side. A stirring structure 202 is provided inside the liquid material cylinder 201; the material of the liquid material cylinder 201 includes but is not limited to glass material, stainless steel material, polymer material, such as polypropylene, polystyrene, polycarbonate, polyethylene (including high-density polyethylene and low-density polyethylene), copolymer PETG, etc., among which glass material is preferred.

[0066] Both the feeding port 203 and the discharging port 204 include covers, which may be rubber plugs or screw caps.

[0067] A suction pipe 3 is inserted into the discharge port 204 , a bottom liquid inlet end of the suction pipe 3 extends into the bottom of the liquid cylinder 201 , and a top liquid outlet end of the suction pipe 3 is connected to a liquid inlet end of the liquid distribution structure 4 .

[0068] The suction tube 3 can be made of stainless steel, glass or polymer.

[0069] Further optimized solution, the stirring structure 202 includes a stirring motor 2021, the stirring motor 2021 is fixedly connected to the middle of the top surface of the liquid material cylinder 201, the output shaft of the stirring motor 2021 penetrates the top wall of the liquid material cylinder 201 and is connected to the stirring shaft 2022, and the outer side of the stirring shaft 2022 is fixedly connected with a plurality of groups of stirring paddles 2023, each group of stirring paddles 2023 includes two stirring paddles 2023 arranged symmetrically on the left and right, and the plurality of groups of stirring paddles 2023 are evenly and evenly distributed along the axis direction of the stirring shaft 2022. The stirring speed of the stirring motor 2021 is controlled by a program, and the stirring paddle 2023 can be made of stainless steel or polymer material, wherein polymer material is preferred.

[0070] Further optimizing the scheme, a liquid level sensor 205 is fixedly connected to the inner wall of the liquid cylinder 201, and the liquid level position sensed by the liquid level sensor 205 is higher than the position of the liquid inlet end at the bottom of the suction pipe 3. The liquid level sensor 205 can measure the liquid level in the liquid cylinder 201. The liquid level sensor 205 is electrically connected to the liquid distribution structure 4. If the liquid level is lower than a certain value, the pump of the liquid distribution structure 4 automatically stops.

[0071] Further optimizing the scheme, the liquid distribution structure 4 includes a silicone hose 401, a pump 1 402, a pump 2 403, a pump 3 404, a cleaning liquid bottle 406, a buffer bottle 405, a six-way valve 407, and a waste liquid tank 408;

[0072] The liquid inlet end of the silicone hose 401 is connected to the liquid outlet end of the suction pipe 3, the liquid outlet end of the silicone hose 401 is connected to the liquid inlet end of the pump 1 402, and the liquid outlet end of the pump 1 402 is connected to the first liquid inlet end of the six-way valve 407; the pump 1 402 is used to distribute the liquid;

[0073] The liquid outlet of the buffer bottle 405 is connected to the liquid inlet of the second pump 403, and the liquid outlet of the second pump 403 is connected to the second liquid inlet of the six-way valve 407; the second pump 403 is used to distribute the buffer;

[0074] The liquid outlet of the cleaning liquid bottle 406 is connected to the liquid inlet of the pump 3 404, and the liquid outlet of the pump 3 404 is connected to the third liquid inlet of the six-way valve 407; the pump 3 404 is used for cleaning the pipeline;

[0075] The pump includes but is not limited to a plunger pump, a peristaltic pump and a gear pump. Among them, a peristaltic pump is preferred.

[0076] The first liquid outlet of the six-way valve 407 is communicated with the liquid inlet of the waste liquid cylinder 408 , and the second liquid outlet of the six-way valve 407 is communicated with the liquid inlet of the purification column tube rack structure 5 .

[0077] An idle port of the six-way valve 407 is plugged with a spiral plug.

[0078] Further optimizing the scheme, the purification column tube rack structure 5 includes a liquid outlet hose 501, the liquid inlet end of the liquid outlet hose 501 is connected to the liquid outlet end of the six-way valve 407, the liquid outlet hose 501 is clamped on the mechanical arm 503, the mechanical arm 503 is fixed to the side wall of the chassis 504, and the chassis 504 is provided with a control panel 502;

[0079] A driving motor 507 is fixedly connected to the middle of the top surface of the chassis 504, and the output shaft of the driving motor 507 is axially connected to the purification column tube rack 506. The edge of the purification column tube rack 506 is provided with a plurality of purification column slots, which are evenly spaced around the circumference. The liquid outlet end of the liquid outlet hose 501 is arranged corresponding to any one of the purification column slots, and the plurality of purification column slots are used to place the purification columns to be loaded.

[0080] A liquid collecting tray structure 505 is provided between the purification column tube rack 506 and the bottom plate 504 . The liquid collecting tray structure 505 is used to collect waste liquid generated during the column packing process.

[0081] The output shaft of the driving motor 507 is connected to a driving wheel, and a driven wheel is fixed to one side of the bottom surface of the purification column tube rack 506. The driving wheel and the driven wheel are meshed and connected. When the driving motor 507 is started, the purification column tube rack 506 is driven to rotate. The driving motor 507 can adjust the speed through the control structure.

[0082] According to a further optimization scheme, the liquid collecting tray structure 505 includes a tray body 5051, and a plurality of liquid collecting grooves 5052 are provided on the edge of the tray body 5051. The plurality of liquid collecting grooves 5052 are evenly spaced around the circumference, and the plurality of liquid collecting grooves 5052 are arranged in one-to-one correspondence with the plurality of purification column grooves.

[0083] A through hole 5053 is formed in the middle of the disk body 5051 , and the driving motor 507 is nested inside the through hole 5053 .

[0084] According to a further optimization scheme, the robot arm 503 includes a base, which is fixedly connected to the side wall of the chassis 504, and the fixed end of the rotating motor is fixedly connected to the middle of the top surface of the base. The output shaft of the rotating motor is connected to an L-shaped bracket, and a snap-in hole is provided on the L-shaped bracket, and the liquid outlet hose 501 is nested inside the snap-in hole.

[0085] Further optimized solution, the sieve plate filling structure 6 includes a bracket 601, the bottom surface of the bracket 601 is symmetrically fixed with two walking wheels 602, the top surface of the bracket 601 is fixed with a support rod 603, the top of the support rod 603 is fixed with a material plate 604, the top surface of the material plate 604 is fixed with a lower material barrel 606 through the bracket, the top surface of the lower material barrel 606 is fixed with a hopper, and the hopper is funnel-shaped;

[0086] The lower barrel 606 is used to hold a plurality of sieve plates, which are arranged in sequence along the axis direction of the lower barrel 606. A gap is left between the bottom surface of the lower barrel 606 and the top surface of the material plate 604. The height of the gap is the thickness of one sieve plate.

[0087] A slide groove is provided on the material plate 604, and a fixed end of a push cylinder 605 is fixedly connected inside the slide groove. The movable end of the push cylinder 605 contacts the screen plate. A vertical rod 607 is fixedly connected to one end of the material plate 604 away from the fixed end of the push cylinder 605, and a fixed end of a linear motor 608 is fixedly connected to the vertical rod 607.

[0088] The material plate 604 is provided with sieve plate holes 609 , and the sieve plate holes 609 are arranged corresponding to any purification column slot.

[0089] A retaining ring is fixedly connected to the inner bottom of the sieve plate hole 609 .

[0090] When in use, first place multiple sieve plates in the discharge barrel 606, and the sieve plates fall down into the gap one by one. When the sieve plate at the bottom falls into the gap, the cylinder 605 pushes the sieve plate to the sieve plate hole 609. The sieve plate will not fall down due to the action of the retaining ring, and the linear motor is started to push the sieve plate downward so that it falls on the purification column tube.

[0091] Each structure can be controlled individually by the control structure, and parameters can be set individually, or unified parameters can be set and controlled by the control structure. Parameters can be set by software to match parameters such as slurry stirring, material suction, distribution, purification column tube rack 506 rotation, and sieve plate pressing, so as to complete the purification column loading action in a coherent manner.

[0092] Embodiment 2:

[0093] The only difference between this embodiment and embodiment 1 is that no retaining ring is provided at the inner bottom of the sieve plate hole 609 of this embodiment. The sieve plate hole 609 of this embodiment is in the shape of a funnel which is wide at the top and narrow at the bottom. The pushing cylinder 605 pushes the sieve plate to the sieve plate hole 609. Since the sieve plate hole 609 is in the shape of a funnel, the sieve plate will be automatically positioned so that the sieve plate will not fall downward. The linear motor is started, and the linear motor pushes the sieve plate downward so that it falls on the column tube of the purification column.

[0094] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0095] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A purification column automatic filling device, characterized in that: include: A liquid storage structure (2), the liquid storage structure (2) is placed inside the temperature control structure (1), and the liquid storage structure (2) is used to store liquid; A liquid distribution structure (4), wherein the liquid inlet end of the liquid distribution structure (4) is connected to the liquid outlet end of the liquid storage structure (2), and the liquid distribution structure (4) is used to control the amount of material added during the column loading process; A purification column tube rack structure (5), wherein the purification column tube rack structure (5) is used to place a plurality of purification columns and load the purification columns, and any one of the purification columns is arranged corresponding to the liquid outlet end of the feed liquid distribution structure (4); A sieve plate filling structure (6), wherein the sieve plate filling structure (6) is used to fill a plurality of sieve plates, wherein the discharge ends of the plurality of sieve plates are arranged corresponding to the feed ends of the purification column tube rack structure (5); The liquid distribution structure (4) comprises a silicone hose (401), a pump 1 (402), a pump 2 (403), a pump 3 (404), a cleaning liquid bottle (406), a buffer bottle (405), a six-way valve (407), and a waste liquid tank (408); The liquid inlet end of the silicone hose (401) is connected to the liquid outlet end of the suction pipe (3), the liquid outlet end of the silicone hose (401) is connected to the liquid inlet end of the pump 1 (402), and the liquid outlet end of the pump 1 (402) is connected to the first liquid inlet end of the six-way valve (407); The liquid outlet of the buffer bottle (405) is connected to the liquid inlet of the second pump (403), and the liquid outlet of the second pump (403) is connected to the second liquid inlet of the six-way valve (407); The liquid outlet of the cleaning liquid bottle (406) is connected to the liquid inlet of the pump three (404), and the liquid outlet of the pump three (404) is connected to the third liquid inlet of the six-way valve (407); The first liquid outlet end of the six-way valve (407) is connected to the liquid inlet end of the waste liquid tank (408), and the second liquid outlet end of the six-way valve (407) is connected to the liquid inlet end of the purification column tube rack structure (5); The purification column tube rack structure (5) comprises a liquid outlet hose (501), the liquid inlet end of the liquid outlet hose (501) is connected to the liquid outlet end of the six-way valve (407), the liquid outlet hose (501) is clamped on a mechanical arm (503), the mechanical arm (503) is fixed on the side wall of a chassis (504), and a control panel (502) is provided on the chassis (504); A driving motor (507) is fixedly connected to the middle of the top surface of the chassis (504), and the output shaft of the driving motor (507) is axially connected to the purification column tube rack (506). A plurality of purification column slots are provided on the edge of the purification column tube rack (506), and the plurality of purification column slots are circumferentially evenly spaced. The liquid outlet end of the liquid outlet hose (501) is arranged corresponding to any one of the purification column slots, and the plurality of purification column slots are used to place purification columns to be loaded; A liquid collecting tray structure (505) is provided between the purification column tube rack (506) and the base plate (504), and the liquid collecting tray structure (505) is used to collect waste liquid generated during the column loading process; The sieve plate filling structure (6) comprises a bracket (601), the bottom surface of the bracket (601) is symmetrically fixed with two running wheels (602), the top surface of the bracket (601) is fixed with a support rod (603), the top end of the support rod (603) is fixed with a material plate (604), the top surface of the material plate (604) is fixed with a lower material barrel (606) through the bracket, the top surface of the lower material barrel (606) is fixed with a hopper, and the hopper is funnel-shaped; The lower barrel (606) is used to hold a plurality of the sieve plates, and the plurality of the sieve plates are arranged in sequence along the axial direction of the lower barrel (606), and a gap is left between the bottom surface of the lower barrel (606) and the top surface of the material plate (604), and the height of the gap is the thickness of one of the sieve plates; The material plate (604) is provided with a slide groove, the interior of which is fixedly connected to the fixed end of a push cylinder (605), the movable end of which is in contact with the screen plate, the end of the material plate (604) away from the fixed end of the push cylinder (605) is fixedly connected to a vertical rod (607), and the fixed end of a linear motor (608) is fixedly connected to the vertical rod (607); The material plate (604) is provided with a sieve plate hole (609), and the sieve plate hole (609) is arranged corresponding to any one of the purification column slots.

2. The automatic filling device for a purification column according to claim 1, characterized in that: The temperature control structure (1) comprises a box (101), a partition (104) is fixedly connected inside the box (101), and the partition (104) divides the box (101) into two upper and lower cavities, the lower cavity is an installation space (102), a refrigeration fan (103) is installed inside the installation space (102), and the upper cavity is a refrigeration space, and the liquid storage structure (2) is fixedly connected inside the refrigeration space; A refrigeration cavity (105) is provided on the side wall of the refrigeration space, and a plurality of refrigeration air plates (106) are installed in the refrigeration cavity (105). The plurality of refrigeration air plates (106) are evenly distributed at intervals, and the air inlet end of the refrigeration air plate (106) is connected to the air outlet end of the refrigeration fan (103).

3. The automatic filling device for a purification column according to claim 2, characterized in that: The liquid storage structure (2) comprises a liquid cylinder (201), the liquid cylinder (201) is fixedly connected inside the refrigeration space, and the height of the liquid cylinder (201) is consistent with the height of the refrigeration chamber (105); A feeding port (203) is provided on one side of the top of the liquid material cylinder (201), and a discharge port (204) is provided on the other side. A stirring structure (202) is provided inside the liquid material cylinder (201); A suction pipe (3) is inserted into the discharge port (204), the bottom liquid inlet end of the suction pipe (3) extends into the bottom of the liquid cylinder (201), and the top liquid outlet end of the suction pipe (3) is connected to the liquid inlet end of the liquid distribution structure (4).

4. The automatic filling device for a purification column according to claim 3, characterized in that: The stirring structure (202) comprises a stirring motor (2021), wherein the stirring motor (2021) is fixedly connected to the middle of the top surface of the liquid cylinder (201), and the output shaft of the stirring motor (2021) passes through the top wall of the liquid cylinder (201) and is connected to a stirring shaft (2022), and a plurality of groups of stirring paddles (2023) are fixedly connected to the outer side of the stirring shaft (2022), and each group of the stirring paddles (2023) comprises two stirring paddles (2023) that are symmetrically arranged on the left and right, and the plurality of groups of the stirring paddles (2023) are evenly and equidistantly distributed along the axial direction of the stirring shaft (2022).

5. The automatic filling device for a purification column according to claim 3, characterized in that: A liquid level sensor (205) is fixedly connected to the inner wall of the liquid cylinder (201), and the liquid level position sensed by the liquid level sensor (205) is higher than the position of the liquid inlet end at the bottom of the suction pipe (3).

6. The automatic filling device for a purification column according to claim 1, characterized in that: The liquid collecting tray structure (505) comprises a tray body (5051), a plurality of liquid collecting grooves (5052) are provided on the edge of the tray body (5051), the plurality of liquid collecting grooves (5052) are distributed at equal intervals in the circumferential direction, and the plurality of liquid collecting grooves (5052) are arranged in one-to-one correspondence with the plurality of purification column grooves; A through hole (5053) is provided in the middle of the disk body (5051), and the driving motor (507) is nested inside the through hole (5053).

7. The automatic filling device for a purification column according to claim 6, characterized in that: The robotic arm (503) includes a base, which is fixedly connected to the side wall of the chassis (504), and the fixed end of the rotary motor is fixedly connected to the middle of the top surface of the base. The output shaft of the rotary motor is connected to an L-shaped bracket, and a clamping hole is opened on the L-shaped bracket. The liquid outlet hose (501) is nested inside the clamping hole.

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