Core microfluidic chip and manufacturing method thereof

Abstract

This invention discloses a core microfluidic chip and its fabrication method. The method includes: acquiring a core scan image of a target block core, and determining the pore throat distribution image of the core scan image; adjusting the pore throat dimensions in the pore throat distribution image according to a reference pore throat size distribution result to obtain a target pore throat image; and fabricating a microfluidic chip corresponding to the target block core based on the target pore throat image. This invention addresses the problem of low correlation between existing core microfluidic chip design methods and actual pore throat structures, improving the correlation between the pore throat structure of the core microfluidic chip and the actual pore throat structure.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of oil and gas field development, and particularly relates to a core micro-fluidic chip and a manufacturing method thereof. BACKGROUND

[0002] There are differences between oil and water seepage rules in micro-nano scale pore throats of an oil reservoir and conventional bulk phases, and it is of great significance to design development schemes and stimulation measures to clarify the three-phase flow characteristics and rules of oil, water and gas in the oil reservoir.

[0003] Microscopic seepage physical experiment methods for the pore throat structure of the oil reservoir include low-field nuclear magnetic resonance technology, computed tomography (CT) technology and micro-fluidic technology. The low-field nuclear magnetic resonance technology or the CT technology can capture rock skeleton or fluid signals and can analyze the flow characteristics in different size pore throats at different displacement times, but cannot directly capture the characteristics of the interface change and the distribution of oil and water of the multiphase fluid. The micro-fluidic technology can clearly observe the single-phase fluid flow characteristics and the interaction characteristics of the multiphase fluid.

[0004] In the manufacturing method of the existing core micro-fluidic chip, one is to manufacture relatively simple and regular channels, and the channels are specifically used to measure important parameters in the flow, for example, can include parameters such as miscible phase pressure, saturation pressure and flow velocity; and the other is a porous medium chip used to simulate the structure of the oil reservoir. Since the oil reservoir is a heterogeneous structure, the difficulty lies in establishing the corresponding relationship between the chip and the real pore throat structure of the oil reservoir core. SUMMARY

[0005] The present application provides a core micro-fluidic chip and a manufacturing method thereof, to solve the problem that the existing design method of the core micro-fluidic chip has low relevance to the actual pore throat structure.

[0006] According to an aspect of the present application, a manufacturing method of a core micro-fluidic chip is provided, and the method comprises:

[0007] obtaining a core scanning image of a core of a target block, and determining a pore throat distribution image of the core scanning image;

[0008] adjusting each pore throat size in the pore throat distribution image according to a reference pore throat size distribution result, to obtain a target pore throat image;

[0009] manufacturing a micro-fluidic chip corresponding to the core of the target block according to the target pore throat image.

[0010] According to another aspect of the present application, a core micro-fluidic chip is provided, which is manufactured according to the manufacturing method of the core micro-fluidic chip of any embodiment of the present application.

[0011] The technical scheme of the embodiment of the present application adjusts the pore throat distribution image by referring to the pore throat size distribution result, solves the problem that the design method of the existing core micro-fluidic chip has low correlation with the actual pore throat structure, and improves the correlation between the pore throat structure of the core micro-fluidic chip and the actual pore throat structure.

[0012] It should be understood that the matters described in this section are not intended to identify key or important features of the embodiments of the present application, nor are they used to limit the scope of the present application. Other features of the present application will become apparent from the following description. BRIEF DESCRIPTION OF DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0014] Figure 1A is a flow chart of a core micro-fluidic chip manufacturing method according to an embodiment of the present application;

[0015] Figure 1B is a schematic diagram of a core scanning image according to an embodiment of the present application;

[0016] Figure 1C is a schematic diagram of a pore distribution image according to an embodiment of the present application;

[0017] Figure 1D is a schematic diagram of a pore throat distribution image according to an embodiment of the present application;

[0018] Figure 2A is a flow chart of another core micro-fluidic chip manufacturing method according to an embodiment of the present application;

[0019] Figure 2B is a schematic diagram of a pore throat center line according to an embodiment of the present application;

[0020] Figure 2C is a schematic diagram of a reference pore throat size distribution result according to an embodiment of the present application;

[0021] Figure 2D is a schematic diagram of a distribution result of an actual pore size according to an embodiment of the present application;

[0022] Figure 2E is a schematic diagram of a target pore throat image according to an embodiment of the present application;

[0023] Figure 2FIt is a schematic diagram of a size distribution result of an actual pore size and a reference pore throat size distribution result according to an embodiment of the present application.

[0024] Figure 2G It is a schematic diagram of a microfluidic chip according to an embodiment of the present application. DETAILED DESCRIPTION

[0025] In order to make the personnel in the art better understand the present application scheme, the technical scheme in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor should belong to the scope of protection of the present application.

[0026] It should be noted that the terms "include" and "have" and any variations thereof in the specification and claims of the present application and the above-mentioned drawings are intended to cover non-exclusive inclusion, for example, a process, method or product containing a series of steps or units does not have to be limited to those steps or units clearly listed, but can include other steps or units not clearly listed or inherent to these processes, methods or products.

[0027] Figure 1A It is a flowchart of a manufacturing method of a core microfluidic chip according to an embodiment of the present application. The present embodiment can be applied to the scene of manufacturing a core microfluidic chip based on a core scanning image.

[0028] As shown in Figure 1A , the manufacturing method of the core microfluidic chip comprises the following steps:

[0029] S110, obtaining a core scanning image of a target block core, and determining a pore throat distribution image of the core scanning image.

[0030] The target block core is a core whose fluid rule and flow characteristics need to be determined.

[0031] The fluid storage and migration space of the target block core includes pores and throats. Generally, the pores are the enlarged parts in the pores, and the small parts connecting different pores are the throats. The pore throat distribution image includes the distribution of the pores and throats of the target block core.

[0032] This embodiment does not specifically limit the method of acquiring core scanning images. For example, the core of the target block can be scanned by micro-computed tomography (Micro-CT) or focused ion double-beam microscope (FIB-SEM) to obtain the core scanning image of the target block core.

[0033] In one specific embodiment, a set of core scan images of a target block can be acquired using Micro-CT. These images can then be filtered according to specific needs. For example, the core scan images can be filtered based on the distribution of structures such as pores and throats to obtain the core scan images to be processed. The advantage of this approach is that it yields higher resolution and clearer images of the pore and throat distribution, further improving the accuracy of the pore and throat structure in the core microfluidic chip.

[0034] In practical applications, the distribution of pores can be seen in the core scan images of the target block core. Throat channels can be generated based on the pore distribution information in the core scan images to obtain the pore throat distribution image of the core scan images.

[0035] Optionally, determining the pore throat distribution image of the core scan image includes: first, performing binarization processing on the pores in the core scan image to obtain a pore distribution image; then, generating throats corresponding to the pores using a watershed algorithm to obtain a pore throat distribution image.

[0036] Understandably, binarizing multiple core scan images can preserve pore shape and location features while removing unwanted noise and shadows. In a specific embodiment, FIB-SEM was used to scan the Chang 6 tight sandstone of the Yanchang Formation in the Ordos Basin, obtaining multiple core scan images of the rock. One of these core scan images is shown below. Figure 1B As shown, binarizing the core scan image only extracts the pore structure, yielding the image corresponding to the pores, which serves as the pore distribution image. This is because the core scan image is a slice scan image of the target block, and may not be able to obtain interconnected pores; that is, the binarized core scan image does not include the throats connecting the pores.

[0037] Furthermore, after binarizing the pores in the core scan image to obtain a pore distribution image, the process includes: determining the actual porosity of the core scan image based on the ratio of the area of ​​all pores in the pore distribution image to the total area of ​​the pore distribution image; and filtering the pore distribution image according to the reference porosity to ensure that the actual porosity matches the reference porosity.

[0038] wherein the reference porosity is the porosity of the real core structure of the core of the target block.

[0039] In one specific embodiment, the actual surface porosity of each of the binarized pore distribution images of the slice scanning images of the target block is determined using existing image processing models, software, tools or algorithms, etc. The difference between the actual surface porosity and the reference porosity is calculated, and the absolute value of the difference is obtained. The minimum value of the absolute value is determined, and the actual surface porosity corresponding to the minimum value is obtained. The pore distribution image corresponding to the actual surface porosity is taken as the final pore distribution image (see Figure 1C ). Then, for the pore distribution image, the throats corresponding to the pores are generated by the watershed algorithm to obtain a pore-throat distribution image, which includes the distribution of the pores and the throats.

[0040] In order to reflect the real pore-throat structure, it is necessary to generate throats connecting the pores. Specifically, the shortest distance between each of the pores in the pore distribution image is detected, and a path connecting each of the pores is generated according to the shortest distance. The path is taken as the throat connecting the pores, and a pore-throat distribution image is obtained. The pore-throat distribution image includes the throats and the pores.

[0041] In one specific embodiment, the pore-throat distribution image (see Figure 1C ) is processed by the watershed algorithm to generate the throats connecting the pores, and a pore-throat distribution image (see Figure 1D ) is obtained. The pore-throat distribution image includes a connected pore-throat structure. This has the advantage that the watershed algorithm has a good response to weak edges, and can obtain a closed continuous edge, which is convenient for subsequent processing of the partially connected network of the pore-throat distribution image.

[0042] Optionally, the pore-throat distribution image is processed using an artificial intelligence model to establish a connection between the pores, to obtain the throats connecting the pores, and to obtain a pore-throat distribution image including the pores and the throats.

[0043] S120, adjusting each pore-throat size in the pore-throat distribution image according to the reference pore-throat size distribution result to obtain a target pore-throat image.

[0044] The reference pore-throat size distribution result reflects the size distribution of each pore-throat in the core scanning image of the core of the target block. Specifically, the reference pore-throat size distribution result can include the size distribution of each pore and throat, and can be the diameter of each pore and throat measured by an existing pore size testing method on a reference block core. For example, the reference pore-throat size distribution result of the target block core can be obtained by a high-pressure mercury injection method or a nitrogen adsorption method.

[0045] Specifically, the pore throat distribution image is adjusted according to the reference pore throat size distribution result, so that the diameter of each pore throat in the pore throat distribution image conforms to the diameter of each pore throat in the reference pore throat size distribution result, and a target pore throat image is obtained.

[0046] Optionally, the size of each pore throat in the pore throat distribution image is adjusted according to the reference pore throat size distribution result, and a target pore throat image is obtained, including:

[0047] The connected domain composed of part of the pore throats is taken as an adjustment unit, and the pore and throat corresponding to a single pixel in the pore throat distribution image are extracted according to the size of the single pixel in the pore throat distribution image and the pore throat size in the reference pore throat size distribution result, and the pore and throat corresponding to the single pixel are enlarged or reduced;

[0048] The throats larger than a set size in the adjustment unit are extracted, the pores in the adjustment unit are extracted, and the pores in the adjustment unit are enlarged or reduced according to the reference pore throat size distribution result;

[0049] The maximum connected domain composed of all the pore throats is obtained, and the image corresponding to the maximum connected domain in the pore throat distribution image is enlarged or reduced according to the reference pore throat size distribution result.

[0050] In the pore throat distribution image, the pore throat includes a pore and a throat, the pore is taken as a vertex of a connected network, the throat is taken as a path connecting the vertices, all the pores and all the throats form a maximum connected domain; all the sub-connected domains of the maximum connected domain are determined, wherein the sub-connected domain includes part of the pores and the throats, and the set of all the sub-connected domains includes all the pores and all the throats; the size of the pore diameter in the pore throat distribution image is adjusted through one of the above operations and / or a combination of multiple operations, and a target pore throat image is obtained, wherein the pore diameter distribution in the target pore throat image conforms to the reference pore throat size distribution result.

[0051] It can be understood that the above multiple operations can be interleaved, and the order and number of the above multiple operations are not specifically limited, as long as the size distribution of each pore throat in the pore throat distribution image conforms to the reference pore throat size distribution result.

[0052] When adjusting the size of each pore throat in the pore throat distribution image, optionally, the sub-connected domain is taken as an adjustment unit, the actual size of a single pixel in the core scanning image of the target block core is taken as the actual size of a single pixel in the pore throat distribution image, and the actual size of the single pixel is compared with the minimum pore throat size in the reference pore throat size distribution result; if the actual size of the single pixel is smaller / larger than the minimum pore throat size, the throats and pores composed of all the single pixels in the pore throat distribution image are extracted, and the throats and pores are enlarged / reduced.

[0053] It can be understood that, in order to preserve the throat and pore composed of single pixels, the throat and pore composed of single pixels can be extracted first, and then the throat and pore part of single pixels is added after adjustment by other operations. Whether the adjustment by the above operation is needed or not can be determined according to the reference pore throat size distribution result.

[0054] Optionally, according to the reference pore throat size distribution result, the pore size in each sub-connected domain of the pore throat distribution image is adjusted. Exemplarily, the size in the reference pore throat size distribution result can be compared with the pore size in each sub-connected domain of the pore throat distribution image in segments. Further, all the pores and throats in the pore throat distribution image larger than a set radius can be selected, and the pores and throats smaller / larger than the set size are enlarged / reduced.

[0055] Optionally, first, the actual size range is determined according to the maximum and minimum values of all the pore diameters in the maximum connected domain composed of all the pores and all the throats in the pore throat distribution image; at the same time, the reference size range corresponding to the maximum and minimum values of all the pore diameters is determined according to the reference pore diameter distribution result; then, the reference size range is compared with the actual size range, and the image corresponding to the maximum connected domain is enlarged / reduced to obtain the target pore throat image.

[0056] S130, according to the target pore throat image, a microfluidic chip corresponding to the target block core is manufactured.

[0057] Specifically, according to the target pore throat image, a microfluidic chip corresponding to the target block core is manufactured, which can realize the quantitative description of the pore throat structure of the target block core and provide an efficient and convenient experimental method for studying the percolation characteristics of multiphase fluid in the pore throat of the heterogeneous target block core.

[0058] It should be noted that the material and manufacturing process for manufacturing the microfluidic chip can be various. In the embodiment, the specific material and manufacturing process can be selected according to the actual needs, which is not limited here.

[0059] In a specific embodiment, in order to simulate the actual reservoir temperature and pressure, the microfluidic chip made of silicon and glass can be selected, which can withstand high temperature and high pressure environment. According to the target pore throat image, the corresponding pore throat structure is formed on one side of the silicon wafer by photolithography and etching method; the glass is used as the cover plate, which can ensure good light transmission and facilitate experimental observation; the glass and the silicon wafer are connected by anode bonding method to obtain the microfluidic chip corresponding to the target block core.

[0060] If there is no high requirement on the temperature and pressure of the experiment, the pore throat structure can be engraved by carbon dioxide laser ablation method and micro-milling method, and polydimethylsiloxane

[0061] Polydimethylsiloxane (PDMS) and Polymethyl Methacrylate (PMMA) are used to make microfluidic chips. The advantage of this is that microfluidic chips have good optical and mechanical properties, and are relatively low cost.

[0062] The technical scheme of the embodiment, by acquiring the core scanning image of the target block core, determines the pore throat distribution image of the core scanning image; according to the reference pore throat size distribution result, the pore throat size in the pore throat distribution image is adjusted to obtain the target pore throat image; and according to the target pore throat image, the microfluidic chip corresponding to the target block core is manufactured, which solves the problem that the existing design method of the core microfluidic chip has low correlation with the actual pore throat structure, and further improves the correlation between the pore throat structure of the core microfluidic chip and the actual pore throat structure.

[0063] Figure 2A The technical scheme of the embodiment, by acquiring the core scanning image of the target block core, determines the pore throat distribution image of the core scanning image; according to the reference pore throat size distribution result, the pore throat size in the pore throat distribution image is adjusted to obtain the target pore throat image; and according to the target pore throat image, the microfluidic chip corresponding to the target block core is manufactured, which solves the problem that the existing design method of the core microfluidic chip has low correlation with the actual pore throat structure, and further improves the correlation between the pore throat structure of the core microfluidic chip and the actual pore throat structure.

[0064] As shown in Figure 2A , the method for manufacturing the core microfluidic chip comprises:

[0065] S210, acquiring the core scanning image of the target block core, and determining the pore throat distribution image of the core scanning image.

[0066] S220, for all pore throats in the pore throat distribution image, extracting the center line of each pore throat, and determining the actual size of each pore throat in the pore throat distribution image according to the distance from each node of the center line to the boundary of the corresponding pore throat.

[0067] Optionally, the existing center line extraction algorithm is used to determine the center line corresponding to each pore in the pore throat distribution image and the center line corresponding to each throat. Specifically, the center line of each pore throat in the pore throat distribution image can include: first, for each pore throat in the pore throat distribution image, the actual distance from each pixel point corresponding to the pore throat to the pore throat boundary is calculated by a topological thinning algorithm; then, the maximum value of the actual distance of each pixel point is obtained, and the pixel point corresponding to the maximum value is taken as a reference node; finally, the reference node is used to form the center line of the pore throat.

[0068] In one specific embodiment, the center line of the pore / throat is determined by determining a set of points farthest from the pore / throat boundary. As shown in FIG. 6, in units of individual pores / throats in the pore throat distribution image, the actual distances of all pixel points in each pore to the pore boundary and the actual distances of all pixel points in each throat to the throat boundary are calculated by a topological thinning algorithm. The extreme value of the actual distances corresponding to the individual pores / throats is calculated, and the pixel point corresponding to the extreme value is taken as a reference node. A line formed by the pixel points corresponding to the reference node constitutes the corresponding center line. Figure 2B

[0069] In the present embodiment, before the actual distances of the nodes of the center line to the corresponding pore / throat boundary are determined, the pore boundaries of each pore and the throat boundaries of each throat in the pore throat distribution image are determined by using an existing edge detection algorithm. Further, the center lines of all pores and throats are extracted according to the above operation, and the actual sizes of each pore and throat in the pore throat distribution image and the proportions of each size are determined according to the distances of the nodes of the center line to the corresponding pore / throat boundary.

[0070] S230, adjusting the sizes of each pore and throat in the pore throat distribution image so that the distribution of the actual sizes conforms to the reference pore size distribution, to obtain a target pore throat image.

[0071] The reference pore size distribution can be understood as the size distribution information of each pore and throat of the reference block core. As described above, according to the sizes of the pores and throats in the reference pore size distribution, the partial / total pores and / or throats in the pore throat distribution image can be enlarged / reduced to make the distribution of the actual pore size conform to the reference pore size distribution.

[0072] In one specific embodiment, the reference pore throat size distribution result of the core scanning image (see FIG. 5) is as shown in FIG. 6, where the horizontal coordinate is the distribution of each pore size, and the vertical coordinate is the proportion of each pore size. According to each pore size and the proportion of each pore size, the pore throat distribution image as shown in FIG. 7 is adjusted. Further, the actual pore size distribution result of the pore throat distribution image as shown in FIG. 8 is as shown in FIG. 9. The target pore throat image obtained after adjustment is as shown in FIG. 10. The actual pore size distribution result (see FIG. 11) of the target pore throat image conforms to the reference pore throat size distribution result. Figure 1B Figure 2C Figure 1D Figure 1D Figure 2D Figure 2E Figure 2F

[0073] S240, manufacturing a microfluidic chip corresponding to the target block core according to the target pore throat image.

[0074] ​​​​​​​​In one specific embodiment, the target pore throat image may be redrawn / converted into another file format. For example, a target pore throat image in raster image format (e.g., a BMP bitmap) may be converted into a DWG file for easier mechanical manufacturing. To ensure connectivity, all curves in the DWG file are continuous and closed.

[0075] In one specific embodiment, a schematic diagram of a microfluidic chip corresponding to the target block core is created based on the target pore throat image. For example... Figure 2G As shown in Table 1, the microfluidic chip is compared with the core parameters of the target block obtained through experiments. Therefore, the microfluidic chip made by this method can quantitatively simulate the pore structure and throat structure of real cores, improve the accuracy of the pore throat structure of the core microfluidic chip, and improve the convenience of subsequent experimental research.

[0076] Table 1

[0077]

[0078] The technical solution of this embodiment adjusts the actual pore diameter of each pore throat according to the reference pore diameter distribution, which solves the problem that the existing design method of core microfluidic chip has low correlation with the actual pore throat structure, and further improves the correlation between the pore throat structure of the core microfluidic chip and the actual pore throat structure.

[0079] The core microfluidic chip provided in the embodiments of the present invention can be obtained by the method of fabricating a core microfluidic chip according to any embodiment of the present invention. The fabrication of the core microfluidic chip can be implemented in hardware and / or software, and has the corresponding beneficial effects of the method.

[0080] It should be understood that the various forms of processes shown above can be used, with steps reordered, added, or deleted. For example, the steps described in this invention can be executed in parallel, sequentially, or in different orders, as long as the desired result of the technical solution of this invention can be achieved, and this is not limited herein.

[0081] The specific embodiments described above do not constitute a limitation on the scope of protection of this invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A method for fabricating a core microfluidic chip, characterized in that, include: Obtain core scan images of the target block core, and determine the pore throat distribution image of the core scan images; Based on the reference pore throat size distribution results, the size of each pore throat in the pore throat distribution image is adjusted so that the diameter of each pore throat in the pore throat distribution image conforms to the diameter of each pore throat in the reference pore throat size distribution results, thereby obtaining the target pore throat image. Based on the target pore throat image, a microfluidic chip corresponding to the core of the target block is fabricated; Determining the pore throat distribution image of the core scan image includes: The pores in the core scan image are binarized to obtain a pore distribution image; The throats corresponding to the pores are generated using the watershed algorithm, thus obtaining the pore-throat distribution image.

2. The method according to claim 1, characterized in that, The reference pore throat size distribution results include the reference pore diameter distribution; The step of adjusting the size of each pore throat in the pore throat distribution image based on the reference pore throat size distribution results includes: For all the pore throats in the pore throat distribution image, extract the center line of each pore throat, and determine the actual size of each pore throat in the pore throat distribution image based on the distance from each node of the center line to the corresponding pore throat boundary; The dimensions of each pore throat in the pore throat distribution image are adjusted so that the distribution of the actual dimensions conforms to the reference pore diameter distribution.

3. The method according to claim 1, characterized in that, After binarizing the pores in the core scan image to obtain a pore distribution image, the process includes: The actual porosity of the core scan image is determined by the ratio of the area of ​​all pores in the pore distribution image to the total area of ​​the pore distribution image. The pore distribution image is filtered according to a reference porosity so that the actual pore surface ratio matches the reference porosity.

4. The method according to claim 2, characterized in that, Extracting the centerline of the throat includes: For each of the aperture throats in the aperture throat distribution image, the actual distance from each pixel corresponding to the aperture throat to the aperture throat boundary is calculated using a topology thinning algorithm; Find the extreme value of the actual distance corresponding to each pixel, and use the pixel corresponding to the extreme value as a reference node; The centerline of the orifice throat is formed according to the reference node.

5. The method according to claim 1, characterized in that, The pore throat includes a pore and a throat passage; The step of adjusting the size of each pore throat in the pore throat distribution image based on the reference pore throat size distribution result to obtain the target pore throat image includes: Using the connected region composed of partial pore throats as the adjustment unit, based on the size of a single pixel in the pore throat distribution image and the pore throat size in the reference pore throat size distribution result, the pores and throats corresponding to a single pixel in each adjustment unit in the pore throat distribution image are extracted, and the pores and throats corresponding to the single pixel are enlarged or reduced.

6. The method according to claim 1, characterized in that, The pore throat includes a pore and a throat passage; The step of adjusting the size of each pore throat in the pore throat distribution image based on the reference pore throat size distribution result to obtain the target pore throat image includes: Extract throats larger than a set size from the adjustment unit, extract pores from the adjustment unit, and enlarge or reduce the pores in the adjustment unit according to the reference pore throat size distribution results.

7. The method according to claim 1, characterized in that, The step of adjusting the size of each pore throat in the pore throat distribution image based on the reference pore throat size distribution result to obtain the target pore throat image includes: Obtain the largest connected region composed of all pore throats, and zoom in or out on the image corresponding to the largest connected region in the pore throat distribution image based on the reference pore throat size distribution result.

8. A core microfluidic chip, characterized in that, The core microfluidic chip is fabricated according to any one of claims 1-7.

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