A device for filtering anticoagulation blood vessel clots

Abstract

The present invention provides an auxiliary device for filtering anticoagulation blood vessel clots, comprising a centrifuge tube, wherein a buoyancy ring is arranged on the inner wall of the centrifuge tube, the buoyancy ring is a hollow annular structure, the outer edge of the buoyancy ring is connected with the upper part of an elastic ring; the elastic ring is an annular body, the ring body of the buoyancy ring is arranged tangent to the ring body of the elastic ring; a plurality of buoyancy ring holes are arranged on the outer surface of the buoyancy ring, a plurality of elastic ring holes are arranged in the inner cavity of the elastic ring, each buoyancy ring hole is connected with an adjacent elastic ring hole through a traction line, the traction line forms a folded shape through the buoyancy ring hole and the elastic ring hole, the elastic ring undergoes centripetal elastic deformation under the pulling action of the traction line, the buoyancy ring forms an inward and downward pre-tightening force through the elastic deformation of the elastic ring and the pulling action of the traction line, the cross-sectional edges of the elastic ring, the buoyancy ring and the traction line form a curved triangle, and the present invention enables inspectors to timely screen out anticoagulated blood that has produced tiny clots.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an auxiliary device for filtering anticoagulation blood vessel clots. Background Art

[0002] Anticoagulation test is a common blood test that can detect multiple medical indicators such as prothrombin time, activated partial thromboplastin time, and thrombin time. It can be used to evaluate blood coagulation function and detect related diseases.

[0003] In anticoagulation testing, most of the indicators such as prothrombin time, activated partial thromboplastin time and thrombin time are checked through plasma, so anticoagulation blood vessels are needed. After the blood in the anticoagulation blood vessels is centrifuged, the upper plasma is extracted for sampling and inspection. Anticoagulation blood vessels generally contain anticoagulants. When collecting anticoagulated blood, the blood needs to be fully mixed with the anticoagulant in the anticoagulation tube in time to make the collected blood in a non-coagulated state.

[0004] Since fresh whole blood contains coagulation factors such as platelets, if the blood collector fails to shake the blood in time or does not shake it sufficiently, the collected blood will not be mixed with the anticoagulant in the anticoagulant blood vessel in time or sufficiently, causing the blood to coagulate and form blood clots. The presence of blood clots will cause errors in the anticoagulation test results. The inspectors can screen and process the blood vessel clots visible to the naked eye in time, but they cannot distinguish the tiny blood clots in time, which increases the workload of the inspectors. Summary of the invention

[0005] In view of the above problems in the prior art, the present invention provides an auxiliary device for filtering anticoagulated blood vessel clots, which can enable inspectors to timely screen out anticoagulated blood that has produced tiny clots.

[0006] A device for filtering anticoagulation blood vessel clots auxiliary comprises a centrifuge tube, wherein the inner wall of the centrifuge tube is provided with a buoyancy ring, wherein the buoyancy ring is a hollow annular structure, wherein the outer edge of the buoyancy ring is connected with the upper part of an elastic ring; wherein the elastic ring is an annular body, wherein the ring body of the buoyancy ring is tangentially arranged with the ring body of the elastic ring; wherein the outer surface of the buoyancy ring is provided with a plurality of buoyancy ring holes, wherein the inner cavity of the elastic ring is provided with a plurality of elastic ring holes, wherein each of the buoyancy ring holes is connected with an adjacent elastic ring hole by a traction line, wherein the traction line passes through the buoyancy ring hole and the elastic ring hole to form a folded shape. state, the elastic ring undergoes centripetal elastic deformation under the pulling action of the traction line, the buoyancy ring forms an inward and downward pre-tightening force through the elastic deformation of the elastic ring and the pulling action of the traction line, the cross-sectional edges of the elastic ring, the buoyancy ring and the traction line form a curved triangle, the cross-sectional edges of the buoyancy ring form the curved edge of the curved triangle, the curved edge is an inwardly concave curved edge, the lower part of the elastic ring is connected with the upper part of the smooth bushing, the smooth bushing is an annular body, and the outer edge of the cross-sectional area of ​​the annular body of the smooth bushing is an arc-shaped contour;

[0007] When the traction line is in a pulled and taut state, the elastic ring is deformed by centripetal bending, the upper part of the inner cavity of the elastic ring is in close contact with the outer surface of the buoyancy ring, the outer diameter of the elastic ring is larger than the inner diameter of the centrifuge tube, and the elastic ring and the centrifuge tube form an interference fit;

[0008] The outer wall of the smooth bushing is attached to the inner wall of the centrifuge tube; the lower end surface of the annular body of the smooth bushing is connected with a filter membrane, the filter membrane is an elastic membrane, and the elastic membrane is hemispherical as a whole; the elastic membrane is a white visible membrane; the buoyancy ring, the elastic ring, and the smooth bushing are made of silica gel;

[0009] The traction line is a medical absorbable fiber line containing albumin. A breaking point is provided in the middle of the traction line. When the traction line breaks, the outer surface of the elastic ring is in contact with the wall of the centrifuge tube, the elastic ring is in an extended posture, and the outer diameter of the buoyancy ring is smaller than the inner diameter of the centrifuge tube.

[0010] The above-mentioned filtration anticoagulation blood vessel clot auxiliary device, wherein the density of the silica gel is 0.3g / cm 3 ~0.8g / cm 3 .

[0011] In the above-mentioned filtering and anticoagulation blood vessel clot auxiliary device, the smooth bushing is made of hard silicone material, and the outer surface of the smooth bushing is a smooth surface.

[0012] The above-mentioned filtering and anticoagulation blood vessel clot auxiliary device, wherein the white visible membrane is a nylon microporous filtration membrane, the nylon microporous filtration membrane is a porous network structure, and the pore size range of the nylon microporous filtration membrane is 6μm to 12μm.

[0013] The above-mentioned filtering and anticoagulation blood vessel clot auxiliary device, wherein a clamping ring is provided on the inner wall of the centrifuge tube, and the distance between the clamping ring and the top of the centrifuge tube is 1 / 3 to 1 / 2 of the total length of the centrifuge tube.

[0014] In the above-mentioned filtering and anticoagulation blood vessel clot auxiliary device, the centrifuge tube can accommodate a blood volume of 2mL to 5mL.

[0015] The above-mentioned filtering and anticoagulation blood vessel clot auxiliary device, wherein, when the combined structure formed by the buoyancy ring, the smooth bushing and the filter membrane is limited by the clamping ring after centrifugation, the distance between the lowest point of the filter membrane and the bottom of the centrifuge tube is greater than 1 / 3 of the total length of the centrifuge tube.

[0016] Beneficial effects: The present invention can generate buoyancy when anticoagulated blood is centrifuged because the density of the buoyancy ring, the elastic ring and the smooth bushing is lower than that of the blood. At the same time, since the albumin in the medical absorbable albumin line can undergo enzymatic hydrolysis reaction with the enzyme in the blood and thus be absorbed, and since the tension on the traction line increases during centrifugation, the traction line breaks quickly at the breaking point, causing the buoyancy ring to flip outward and upward, and generate an upward reinforcing force together with the buoyancy of the buoyancy ring, so that the combined structure formed by the buoyancy ring, the elastic ring, the smooth bushing and the filter membrane can antagonize the downward impact force of the red blood cells during centrifugation, and then move upward. At the same time, tiny blood clots can be retained on the filter membrane, and the inspector can timely screen and distinguish the anticoagulated blood that has produced tiny clots, and extract plasma samples to check the prothrombin time, activated partial thromboplastin time, and thrombin time anticoagulation items. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a front view of the blood vessel clot auxiliary device for filtering and anticoagulation according to one embodiment of the present invention before anticoagulation;

[0018] Figure 2 for Figure 1 The enlarged view of point A in the middle;

[0019] Figure 3 A front view of the filtration and anticoagulation blood vessel clot auxiliary device after centrifugation according to an embodiment of the present invention;

[0020] Figure 4 A three-dimensional schematic diagram of a combined structure formed by a buoyancy ring, an elastic ring, a smooth bushing and a filter membrane;

[0021] Figure 5A bottom view of the combined structure formed by the buoyancy ring, the elastic ring, the smooth bushing and the filter membrane;

[0022] Figure 6 is a three-dimensional schematic diagram of the buoyancy circle;

[0023] Figure 7 It is an enlarged cross-sectional view of the buoyancy ring, elastic ring, buoyancy ring hole, elastic ring hole and traction line.

[0024] Figure numerals: 1-centrifuge tube, 2-filter membrane, 3-clamp ring, 4-buoyancy ring, 4a-buoyancy ring hole, 5-smooth bushing, 6-elastic ring, 6a-elastic ring hole, 7-traction line, 8-red blood cell sedimentation layer, 9-plasma layer. DETAILED DESCRIPTION

[0025] In order to facilitate understanding of the present invention, the present invention will be described more fully below with reference to various embodiments, but the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0026] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0027] like Figures 1 to 7 A filtering anticoagulant blood vessel clot auxiliary device includes a centrifuge tube 1, the inner wall of the centrifuge tube 1 is provided with a buoyancy ring 4, the buoyancy ring 4 is a hollow ring structure, the hollow setting reduces the overall density of the buoyancy ring 4, and further increases the buoyancy of the buoyancy ring 4, and the outer edge of the buoyancy ring 4 is connected with the upper part of the elastic ring 6.

[0028] In this embodiment, the elastic ring 6 is annular, and the ring body of the buoyancy ring 4 is arranged tangentially to the ring body of the elastic ring 6; a plurality of buoyancy ring holes 4a are provided on the outer surface of the buoyancy ring 4, and a plurality of elastic ring holes 6a are provided in the inner cavity of the elastic ring 6, each buoyancy ring hole 4a is connected to an adjacent elastic ring hole 6a by a traction line 7, and the traction line 7 forms a folded shape through the buoyancy ring hole 4a and the elastic ring hole 6a, and the elastic ring 6 undergoes centripetal elastic deformation under the pulling action of the traction line 7, and the buoyancy ring 4 forms an inward and downward pre-tightening force through the elastic deformation of the elastic ring 6 and the pulling action of the traction line, and the cross-sectional edges of the elastic ring 6, the buoyancy ring 4, and the traction line 7 form a curved triangle, and the cross-sectional edges of the buoyancy ring 4 form a curved edge of the curved triangle, and the curved edge is a concave curved edge, and the lower part of the elastic ring 6 is connected to the upper part of the smooth bushing 5, and the smooth bushing 5 is annular, and the outer edge of the cross-sectional area of ​​the annular body of the smooth bushing 5 is an arc-shaped contour.

[0029] In this embodiment, when the traction line 7 is in a pulled and taut state, the elastic ring 6 undergoes centripetal bending deformation, and the upper part of the inner cavity of the elastic ring 6 is tightly attached to the outer surface of the buoyancy ring 4, and pressure is generated on the elastic ring 6, so that the outer diameter of the elastic ring 6 is larger than the inner diameter of the centrifuge tube 1, and the elastic ring 6 forms an interference fit with the centrifuge tube 1, so that the ring body of the elastic ring 6 can fit tightly against the inner wall of the centrifuge tube 1, and the combined structure formed by the buoyancy ring 4, the elastic ring 6, the smooth bushing 5 and the filter membrane 2 is placed on the bottom of the centrifuge tube 1.

[0030] The outer wall of the smooth bushing 5 is attached to the inner wall of the centrifuge tube 1; the lower end surface of the annular body of the smooth bushing 5 is connected with a filter membrane 2, and the filter membrane 2 is an elastic membrane, and the elastic membrane is hemispherical as a whole. The hemispherical design and elastic setting of the filter membrane 2 can buffer the impact force of red blood cells under the action of centrifugal force and avoid damage to the red blood cell membrane.

[0031] In this embodiment, the elastic membrane is a white visible membrane, so that the inspector can observe the blood clot trapped on the white visible membrane. The buoyancy ring 4, the elastic ring 6 and the smooth bushing 5 are made of silica gel.

[0032] In this embodiment, the traction line 7 is a medical absorbable fiber line. The medical absorbable fiber line contains albumin. The albumin in the medical absorbable albumin line can undergo enzymatic hydrolysis reaction with enzymes in the blood and thus be absorbed.

[0033] In this embodiment, a breaking point is provided in the middle of the traction line 7, and the traction line 7 is broken due to the enzymatic hydrolysis of albumin and the increase of tension during centrifugation. When the traction line 7 is broken, the elastic ring 6 is in an extended posture, and the outer surface of the elastic ring 6 is in contact with the wall of the centrifuge tube 1, so that blood is prevented from being retained in the gap between the inner wall of the centrifuge tube 1 and the outer surface of the elastic ring 6. The outer diameter of the buoyancy ring 4 is smaller than the inner diameter of the centrifuge tube 1, so that the floating resistance of the buoyancy ring 4 is reduced.

[0034] Through the above-mentioned structural arrangement, when the device is centrifuging anticoagulated blood, the buoyancy generated by the density of the buoyancy ring 4, the elastic ring 6 and the smooth bushing 5 being lower than the density of the blood, the traction line 7 breaks, and the elastic ring 6 is released to stretch, so that the buoyancy ring 4 is flipped outward and upward, and an upward reinforcing force is generated together with the buoyancy of the buoyancy ring 4, so that the combined structure formed by the buoyancy ring 4, the elastic ring 6, the smooth bushing 5 and the filter membrane 2 can antagonize the downward impact force of the red blood cells during centrifugation, and then move upward. At the same time, tiny blood clots can be trapped on the visible membrane, and the inspector can timely screen and distinguish the anticoagulated blood that has produced tiny clots.

[0035] In addition, in this embodiment, the buoyancy ring 4, the elastic ring 6, and the smooth bushing 5 are made of silicone, and the density of the silicone is 0.3 g / cm 3 ~0.8g / cm 3 , so that the buoyancy ring 4 can generate greater buoyancy in the blood.

[0036] In this embodiment, the smooth bushing 5 is made of hard silicone material. The outer surface of the smooth bushing 5 is a smooth surface, so that the smooth bushing 5 before centrifugation can be closely attached to the inner wall of the centrifuge tube 1. During centrifugation, the sliding friction force on the outer surface of the smooth bushing 5 is reduced, thereby reducing the resistance of the smooth bushing 5 to rise; the inner surface of the smooth bushing 5 is a smooth surface, so that the red blood cells or blood clots slide along the inner wall of the smooth bushing 5 to the filter membrane 2 during centrifugation.

[0037] In this embodiment, the filter membrane 2 is preferably a nylon microporous filter membrane, which has a porous network structure. The pore size range of the nylon microporous filter membrane 2 is 6μm to 12μm. Since the size of a single red blood cell is approximately 6μm to 8μm, the pore size of the nylon microporous filter membrane 2 can smoothly pass a single red blood cell to intercept tiny blood clots. At the same time, due to the elastic setting of the nylon microporous filter membrane 2, the squeezing force on the red blood cells when passing through the filter membrane 2 can be reduced, thereby causing damage to the red blood cell membrane.

[0038] In this embodiment, a clamping ring 3 is provided on the inner wall of the centrifuge tube 1, and the distance between the clamping ring 3 and the top of the centrifuge tube 1 is 1 / 3 to 1 / 2 of the total length of the centrifuge tube 1. The centrifuge tube 1 can accommodate a blood volume of 2 mL to 5 mL. When the combined structure formed by the buoyancy ring 4, the smooth bushing 5 and the filter membrane 2 is limited by the clamping ring 3 after centrifugation, the distance between the lowest point of the filter membrane 2 and the bottom of the centrifuge tube 1 is greater than 1 / 3 of the total length of the centrifuge tube 1, and the height of the red blood cell sedimentation layer 8 after centrifugation is less than 1 / 3 of the total length of the centrifuge tube 1. Therefore, in the anticoagulated blood after centrifugation, the filter membrane 2 can stay in the lower layer of the plasma layer 9, which is convenient for the inspector to observe whether tiny blood clots are retained on the nylon microporous filter membrane 2.

[0039] The working process of this embodiment is as follows:

[0040] 1. The blood collector uses an anticoagulant blood tube to draw blood from the patient, and promptly shakes and mixes the anticoagulant blood tube to fully mix the blood sample and anticoagulant to obtain an anticoagulant blood sample.

[0041] 2. For samples suspected of having tiny blood clots, this device can be used for blood clot detection. The tester puts the buoyancy ring 4, elastic ring 6, smooth bushing 5, and filter membrane 2 pulled by the traction line 7 into the bottom of the centrifuge tube 1, and inserts the clamp ring 3 into the 1 / 3 to 1 / 2 of the inner wall of the centrifuge tube 1. Pour the anticoagulated blood sample that needs to be tested for blood clots into the centrifuge tube 1 of this device, cover the tube cover tightly, and put it into the centrifuge. The parameters are set to 3000r / min and the time is 15 minutes. The buoyancy generated by the density of the buoyancy ring 4, the elastic ring 6 and the smooth bushing 5 is lower than the density of the blood. At the same time, due to the breakage of the traction line 7, the centripetal downward traction of the elastic ring 6 and the buoyancy ring 4 disappears, and the elastic ring 6 is released to stretch, while driving the buoyancy ring 4 to flip outward and upward, so that the combined structure formed by the buoyancy ring 4, the elastic ring 6, the smooth bushing 5 and the filter membrane 2 can antagonize the downward impact force of the red blood cells during centrifugation, and then move upward. At the same time, tiny blood clots can be trapped on the filter membrane 2.

[0042] 3. After centrifugation, the blood clot auxiliary device can be used to filter and distinguish whether there is blood clot in the anticoagulated blood. There are three situations:

[0043] (1) When the buoyancy ring 4 is restricted by the clamping ring 3, the combined structure formed by the buoyancy ring 4, the elastic ring 6, the smooth bushing 5 and the filter membrane 2 is located at the lower part of the plasma layer 9, and there is no blood clot on the filter membrane 2, then the anticoagulated blood is effective anticoagulated blood, and the anticoagulation test can be further performed by retaining the plasma in the upper layer of the plasma.

[0044] (2) When the buoyancy ring 4 is restricted by the clamping ring 3 or is not restricted by the clamping ring 3, the combined structure formed by the buoyancy ring 4, the elastic ring 6, the smooth bushing 5 and the filter membrane 2 is located at the lower part of the plasma layer 9, and blood clots are trapped on the filter membrane 2, then the anticoagulated blood is ineffective anticoagulated blood.

[0045] (3) When the buoyancy ring 4 is not restricted by the clamping ring 3 and the filter membrane 2 has not risen to the plasma layer 9, it can be determined that the anticoagulated blood is invalid. The buoyancy ring 4 is clamped with a sterile clamp so that the combined structure formed by the buoyancy ring 4, the elastic ring 6, the smooth bushing 5 and the filter membrane 2 rises to the plasma layer 9, which further confirms that the anticoagulated blood is invalid.

[0046] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A filtration and anticoagulation blood vessel clot auxiliary device, characterized in that: The centrifuge tube comprises a buoyancy ring provided on the inner wall of the centrifuge tube, the buoyancy ring is a hollow ring structure, the outer edge of the buoyancy ring is connected with the upper part of the elastic ring; the elastic ring is an annular body, the ring body of the buoyancy ring is tangent to the ring body of the elastic ring; the outer surface of the buoyancy ring is provided with a plurality of buoyancy ring holes, the inner cavity of the elastic ring is provided with a plurality of elastic ring holes, each of the buoyancy ring holes is connected with the adjacent elastic ring holes by a traction line, the traction line passes through the buoyancy ring holes and the elastic ring holes to form a folded shape, and the elastic ring The buoyancy ring undergoes centripetal elastic deformation under the pulling action of the traction line, and forms an inward and downward pre-tightening force through the elastic deformation of the elastic ring and the pulling action of the traction line. The cross-sectional edges of the elastic ring, the buoyancy ring and the traction line form a curved triangle. The cross-sectional edges of the buoyancy ring form the curved edge of the curved triangle, and the curved edge is an inwardly concave curved edge. The lower part of the elastic ring is connected with the upper part of the smooth bushing, and the smooth bushing is an annular body. The outer edge of the cross-sectional area of ​​the annular body of the smooth bushing is an arc-shaped contour. When the traction line is in a pulled and taut state, the elastic ring is deformed by centripetal bending, the upper part of the inner cavity of the elastic ring is in close contact with the outer surface of the buoyancy ring, the outer diameter of the elastic ring is larger than the inner diameter of the centrifuge tube, and the elastic ring and the centrifuge tube form an interference fit; The outer wall of the smooth bushing is attached to the inner wall of the centrifuge tube; the lower end surface of the annular body of the smooth bushing is connected with a filter membrane, the filter membrane is an elastic membrane, and the elastic membrane is hemispherical as a whole; the elastic membrane is a white visible membrane; The buoyancy ring, the elastic ring and the smooth bushing are made of silicone; The traction line is a medical absorbable fiber line, and the medical absorbable fiber line contains albumin. A breaking point is arranged in the middle of the traction line. When the traction line breaks, the outer surface of the elastic ring is in contact with the wall of the centrifuge tube, the elastic ring is in a stretched posture, and the outer diameter of the buoyancy ring is smaller than the inner diameter of the centrifuge tube. The density of the silica gel is 0.3 g / cm 3 ~0.8g / cm 3 ; A clamp ring is provided on the inner wall of the centrifuge tube, and the distance between the clamp ring and the top of the centrifuge tube is 1 / 3 to 1 / 2 of the total length of the centrifuge tube; When the combined structure formed by the buoyancy ring, the smooth bushing and the filter membrane is limited by the clamping ring after centrifugation, the distance between the lowest point of the filter membrane and the bottom of the centrifuge tube is greater than 1 / 3 of the total length of the centrifuge tube.

2. The filtration and anticoagulation blood vessel clot auxiliary device according to claim 1, characterized in that: The smooth bushing is made of hard silicone material, and the outer surface of the smooth bushing is a smooth surface.

3. The filtration and anticoagulation blood vessel clot auxiliary device according to claim 1, characterized in that: The white visible film is a nylon microporous filter membrane, the nylon microporous filter membrane is a porous network structure, and the pore size range of the nylon microporous filter membrane is 6 μm to 12 μm.

4. The filtration and anticoagulation blood vessel clot auxiliary device according to claim 1, characterized in that: The centrifuge tube can accommodate a blood volume of 2 mL to 5 mL.

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