A real-time atomization treatment effect evaluation system

Abstract

The present invention relates to a real-time atomization treatment effect evaluation system, comprising: an inhalation drug administration module, configured to provide a patient with a drug to be administered through the respiratory tract in an atomization manner, which is provided with a flow detection device to obtain the drug flow data related to time when the patient uses it; an auxiliary respirator, configured to be able to be attached to the body surface of the patient's respiratory area, to collect the breath sound / lung sound signals related to time when the patient uses it; an information processing module that generates instructions for adjusting the inhalation drug administration module based on the information collected by the auxiliary respirator. Based on the correlation analysis between the breath sound / lung sound signals collected by the auxiliary respirator and the drug flow data, the information processing module generates adjustment instructions for the atomization position, breathing mode and / or atomization drug ratio. The present application uses breath sound / lung sound signals to judge the patient's breathing state during the atomization process, and obtains the effect of the patient in the atomization process in real time through the breathing state.

Description

Technical Field

[0001] The invention relates to the technical field of drug injection pumps, and in particular to a real-time atomization treatment effect evaluation system. Background Art

[0002] Nebulizer therapy is currently a commonly used treatment or auxiliary treatment method for respiratory diseases and nasopharyngeal diseases. Through professional equipment, the prepared medicine is delivered to the designated part, ultimately achieving the purpose of treating the disease. It is of great significance for the treatment of nasopharyngeal diseases and respiratory diseases.

[0003] When conducting nebulization therapy, medical devices such as jet nebulizers, ultrasonic nebulizers, and oxygen-driven nebulizers are mainly used.

[0004] The jet nebulizer is currently the most commonly used nebulizer in clinical practice. Each time, 4 to 6 mL of liquid medicine is inserted, and the electric-driven gas flow rate is 6 to 8 L / min. The principle of ultrasonic nebulizer is to emit high-frequency electrical energy through ultrasonic waves to destroy the surface tension of the drug, prompting the drug to be converted into fine particles, and reach the diseased area with breathing. Oxygen-driven nebulizer, connect the disposable nebulizer inhaler to the oxygen meter. Distilled water should not be added to the humidification bottle of the oxygen meter, and it should be kept dry. It is advisable to adjust the oxygen flow rate to 6 to 8 L / min. If the flow rate is too small, the amount of mist will be small, affecting the inhalation and diffusion of the drug. If the flow rate is too large, it will cause discomfort in the patient's throat and damage the respiratory mucosa.

[0005] In the prior art, the adjustment of atomization parameters is delayed and can only be detected when the patient has corresponding indications or abnormal reactions. The efficacy of atomization drugs can only be understood during follow-up visits after a course of treatment. In particular, most children cannot cooperate with the correct breathing method during atomization and cannot timely understand whether the atomization is standard. When the atomized drugs need to reach the lungs and are affected by the children's breathing frequency so that most of the drugs are only retained in the respiratory tract or even the throat, the children need to inhale excessive drugs to achieve the expected efficacy.

[0006] Regarding the prior art regarding respiratory frequency and nebulized drug administration frequency, a Chinese patent application with publication number CN116212177A involves a nebulized drug administration system and a control method thereof, which discloses a drug administration method using a nebulizer device, the method comprising: obtaining a respiratory signal detected by a respiratory sensor located on a first ventilation duct; determining a respiratory state through the respiratory signal; if the respiratory state is an inhalation state, adjusting the frequency of the nebulizer device in the nebulizer through the host of the nebulizer to control the nebulizer device to nebulize the stored medicine and transmit the nebulized medicine to the first ventilation duct; if the respiratory state is an exhalation state, adjusting the frequency of the nebulizer device through the host to control the nebulizer device to stop nebulizing the medicine; obtaining exhaled gas through a pulmonary function tester located on a second ventilation duct, and calculating vital capacity parameters based on the gas.

[0007] The above disclosed technical solution is only used for the regulation of the same frequency breathing, and cannot evaluate the atomization effect. That is, the technical solution reduces the airflow conflict between atomization and breathing frequency by means of the same frequency regulation, but the technical solution cannot provide real-time feedback on the atomization effect, nor can it regulate other factors that reduce the atomization efficiency during the atomization process. At the same time, most of the current standard systems mostly use the evaluation of children's cough and lung function indicators after a few days of atomization to evaluate the atomization and medicinal effects. Therefore, there is a need for an evaluation system that can respond to the atomization inhalation effect in real time.

[0008] In addition, on the one hand, there are differences in understanding among those skilled in the art; on the other hand, the applicant studied a large number of documents and patents when making the present invention, but due to space limitations, not all details and contents are listed in detail. However, this does not mean that the present invention does not have the characteristics of these prior arts. On the contrary, the present invention already has all the characteristics of the prior art, and the applicant reserves the right to add relevant prior art to the background technology. Summary of the invention

[0009] The prior art has already appeared a technical solution that adjusts the oxygen supply flow rate and the atomization drug flow rate according to the patient's respiratory frequency and other physiological parameters to achieve a balance between the inhaled volume and the exhaled volume to ensure that the drug is fully absorbed. For example, a Chinese patent application with publication number CN116920229A discloses a nebulizer for elderly respiratory patients, including an atomizer mask, an oxygen source, a nebulizer, an air supply chamber, a respiratory detection instrument and a controller. One side of the nebulizer is connected to a high-pressure air pump to disperse the solution contained inside through the input air flow, and one side is also connected to a spray valve to output the dispersed drug mist. The spray valve is provided with an atomization flowmeter to detect the real-time dispersed particle size of the drug mist and the atomization air flow rate. The technical solution adjusts the initial air flow rate according to the change rate of the real-time respiratory frequency and the second standard respiratory frequency to ensure that the oxygen supply of the atomization is consistent with the respiratory frequency, that is, the respiratory frequency is faster, and a higher gas flow rate is used to produce a higher spray, so that the drug is better inhaled by the user, and the controller is used to adjust the drug particle size and the drug spraying flow rate to improve the drug utilization rate. However, the process of subtracting the gas flow from the measured exhaled gas involved in this technical solution actually obtains the difference between the exhaled gas flow of the human body and the gas flow input to the mask. For a specific human body, the gas inhaled into the human body and the gas exhaled from the human body are not equivalent, that is, the gas flow is not equivalent. Therefore, the measurement of the exhaled gas flow alone cannot be associated with the amount of medicine inhaled into the respiratory tract by the user, and thus an accurate flow adjustment strategy that matches the patient's real-time physiological state cannot be obtained.

[0010] The present application provides a system for evaluating the real-time therapeutic effect of nebulization, comprising: an inhalation drug administration module, configured to provide a patient with a drug to be administered through the respiratory tract in an nebulized manner, and provided with a flow detection device to obtain time-related drug flow data when the patient uses the drug; an auxiliary respirator, configured to be able to be attached to the body surface of the patient's respiratory area, to collect time-related breathing sound / lung sound signals when the patient uses the drug; and an information processing module that generates instructions for adjusting the inhalation drug administration module based on the information collected by the auxiliary respirator.

[0011] Based on the correlation analysis between the breath sound / lung sound signals collected by the assisted respirator and the drug flow data, the information processing module generates adjustment instructions on the atomization position, breathing mode and / or atomization drug ratio.

[0012] Compared with the above-mentioned prior art, the processing module of the present invention can perform correlation analysis based on the breathing sound / lung sound signals collected by the ventilator and the drug flow data, and generate adjustment instructions for the inhalation drug delivery module regarding the atomization position, breathing mode and / or atomization drug ratio. Based on the above-mentioned distinguishing technical features, the problems to be solved by the present invention may include: how to adjust the implementation parameters of the atomization therapy according to the patient's real-time physiological state, so as to respond to changes in the patient's physiological state in a timely manner and improve the efficiency of the atomization therapy. Beneficial effects of this technical solution:

[0013] The present application uses respiratory sound / lung sound signals to judge the patient's respiratory status during the nebulization process, and obtains the effect of the patient's nebulization process in real time through the respiratory status, such as the relief of sputum and dampness. On the one hand, it can confirm whether the nebulization program can enable the drug to reach the desired area of ​​action through the patient's nebulization effect; on the other hand, it can also confirm whether the nebulized drug is effective for the patient through the relief or no change of the patient's respiratory tract / lung symptoms represented by the respiratory sound / lung sound signals.

[0014] This adjustment process relies on breath sound / lung sound signals. The data fed back by such signals are the reactions generated by the area where the atomized drug directly acts. Compared with the prior art method for improving the atomization efficiency based on the cooperation with the patient during the atomization process, the present application can generate the adjustment of the atomization device in real time through the feedback generated by the area where the atomization directly acts.

[0015] According to a preferred embodiment, the information processing module is configured to generate a nebulization flow rate adjustment instruction related to the patient's respiratory frequency adjustment based on the frequency of the breath sound / lung sound signal collected by the auxiliary ventilator.

[0016] The prior art has already presented a technical solution for achieving efficient inhalation of liquid medicine in the upper respiratory tract or lungs by synchronizing the respiratory frequency of the patient's breathing process. For example, a Chinese patent application with publication number CN115569275A discloses a medical microgrid atomization method and system for synchronizing the respiratory frequency, the system comprising an electrocardiogram and respiratory monitoring unit, an atomization control unit, an atomization drive unit and a microgrid atomization sheet, wherein the electrocardiogram and respiratory monitoring unit monitors the human respiratory state in real time, monitors the real-time data of the respiratory state of the patient during atomization treatment and transmits the monitored real-time data of the respiratory state to the atomization control unit, the atomization control unit extracts the real-time characteristic parameters of the respiratory state according to the real-time data of the respiratory state monitored during atomization of the patient, and controls and adjusts the increase or decrease of the driving peak voltage and vibration frequency of the microgrid atomization sheet through the boost control drive circuit and the frequency modulation control drive circuit of the atomization drive unit, so that its driving peak voltage and vibration frequency change with the real-time characteristic parameters of the respiratory state, and realizes that the atomization amount and atomization rate of the atomization system are synchronized with the respiratory rhythm in real time. The change cycle of the atomization volume and atomization rate of the atomization system of this technical solution can be synchronized in real time with the patient's breathing rhythm, thereby solving the technical problems that the existing atomization system cannot adapt to the patient's breathing, resulting in the inability to efficiently inhale the drug solution into the upper respiratory tract or lungs and cannot monitor the patient's safe atomization status.

[0017] Beneficial effects of this technical solution:

[0018] The present application is provided with an auxiliary respirator that prompts the patient to exhale or inhale. The information processing module controls the auxiliary respirator to generate corresponding breathing prompts at a preset time (e.g., 0.5s) ahead of the medication rhythm of the inhalation medication module, so as to correct the time error caused by the coordination of the patient's inhalation action and the nebulizer medication action caused by the atomization transmission.

[0019] In the prior art, the configuration issues of respiratory rate and drug administration frequency are mostly focused on the patient's own consciousness transformation, while neglecting the drug administration delay caused by the drug administration route, resulting in the adjustment of drug administration frequency and respiratory rate being affected by objective factors.

[0020] The technical solution involved in the present application solves the drug administration delay problem caused by coordinating the drug administration path, so that the coordination between the drug administration frequency and the respiratory rate of the device is only affected by the patient's cooperation, eliminating the influence of other objective conditions on the coordination between the drug administration frequency and the respiratory rate.

[0021] According to a preferred embodiment, the information processing module is configured as follows:

[0022] Based on the intensity of the breath sound / lung sound signal collected by the auxiliary ventilator, a nebulized particle adjustment instruction related to the change of the patient's sputum and dampness symptoms is generated.

[0023] According to a preferred embodiment, the information processing module is configured to generate adjustment instructions for alleviating abnormal symptoms of the patient caused by atomization based on abnormal changes in the breath sound / lung sound signals collected by the ventilator.

[0024] Compared with the above-mentioned prior art, the information processing module of the present invention can generate atomization particle adjustment instructions related to the changes in the patient's phlegm and dampness symptoms according to the intensity of the breath sound / lung sound signal collected by the auxiliary respirator. Based on the above-mentioned distinguishing technical features, the problems to be solved by the present invention may include: how to adjust the drug action site under phlegm and dampness symptoms to improve the effectiveness of the corresponding drug in treating specific diseases. Beneficial effects of this technical solution:

[0025] The diameter of atomized particles is an important factor affecting the deposition of drugs in different parts of the respiratory tract. The existing technology, such as the individualized precise positioning intelligent control atomization system disclosed in the Chinese patent application with publication number CN117224786A, adjusts the size of atomized particles by inversely calculating the inhalation parameters deposited in the part, and uses numerical simulation combined with atomization experiments to study the deposition law of a new type of atomized drug mixture in the human airway, and establishes different drug inhalation parameter databases to judge the matching degree between the diameter of atomized particles and patients.

[0026] According to actual operation, individual differences are large, and the calculation model will be affected by individual differences (such as patients with complications, patients with congenital airway stenosis), which will increase the error of atomized particle adjustment and cause the adjusted parameters to be inapplicable to patients. Different from the above-mentioned prior art, the present application is based on the dynamic change information of lung sounds / breath sounds detected in real time to obtain whether the current atomized particle size matches the site where it is to be deposited. Specifically, by comparing the lung sounds / breath sounds produced by various parts of the same patient before and during atomization, the information processing module can obtain the audio generated by the atomized airflow in the lung sounds / breath sounds after excluding the lung sounds / breath sounds produced by the patient's normal breathing during the atomization process. The end point of the atomized airflow can be known through the site where the above audio is generated, thereby confirming the effect of the current atomization.

[0027] According to a preferred embodiment, the information processing module is configured as follows:

[0028] It is connected to the remote medical care end. When the remote medical care end receives one or more breath sound / lung sound signals collected by the ventilator from the patient, it controls the inhalation drug administration module to adjust the drug ratio of the patient's atomization based on the drug ratio instruction sent by the remote medical care end.

[0029] Beneficial effects of this technical solution:

[0030] The adjustment of the drug ratio involved in this application is applicable to patients with chronic diseases who require long-term or high-frequency home nebulization, such as patients with chronic obstructive pulmonary disease. Such patients have limited mobility and are easily affected by the environment, causing disease manifestations in the lungs that affect the quality of life, such as phlegm-prone cough and asthma in haze weather. Then, affected by the ability to move, going to the hospital for a physical examination when disease manifestations appear will reduce the patient's subjective initiative to nebulize or change medications to reduce the impact of disease manifestations on quality of life.

[0031] The system involved in the present application can remotely communicate with medical staff responsible for the diagnosis and treatment of patients with chronic diseases with the authorization of the HIS system (Hospital Information System) installed in the hospital, and adjust the atomized drug ratio under the guidance of the medical staff within the permitted authority (for example, sending the symptoms of the patient's impact to the medical staff or sending the patient's medical history to the medical staff with the permission of both parties).

[0032] On the one hand, the present application takes into account the compatibility of the drug with the patient during use; on the other hand, it takes into account the drug ratio of each atomization in a course of treatment, so that the entire atomization course can change with the patient's physical changes (such as the development of respiratory diseases or changes caused by environmental influences). The changes not only occur during the atomization process, but also before and after a single atomization. This makes the system involved in the present application fit the patient's condition and improves the atomization effect.

[0033] According to a preferred embodiment, the assisted breathing apparatus comprises a breathing sound collection unit capable of collecting breath sounds from the upper respiratory tract and lungs of the patient.

[0034] According to a preferred embodiment, the assisted respirator also includes an inflatable garment for assisting the patient in adjusting the breathing rate, wherein the fluid supply unit is configured as a garment that can be worn on the patient's body, the garment includes a front face of the garment, a back face of the garment, and at least an inflatable air bag incorporated in or on the back face of the garment, and the front face of the garment and / or the back face of the garment include a recess configured to be pressed against the patient's body surface for placing the respiratory sound collection unit.

[0035] According to a preferred embodiment, when the inflatable airbag is inflated so that the worn garment is pressed against the patient's body surface, the respiratory sound collection unit placed in the recess can at least collect the patient's bronchial respiratory sounds, alveolar respiratory sounds and / or bronchoalveolar respiratory sounds.

[0036] According to a preferred embodiment, the inhalation drug administration module includes a driving unit, a medicine liquid box regulated by the driving unit, and an atomization unit that converts the medicine liquid into an aerosol, wherein the driving unit includes a joint assembly arranged between the medicine liquid box and the atomization unit, and the joint assembly includes a needle and a suction pump. Under the regulation of the information processing module, the needle can pierce the medicine bottle engaged in the medicine liquid box and, under the action of the suction pump, allow the medicine liquid in the medicine bottle to flow into the atomization unit.

[0037] According to a preferred embodiment, the drug liquid box includes a first drug liquid box and a second drug liquid box, and the first drug liquid box and the second drug liquid box can be independently regulated by the driving unit to administer the drug. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 A diagram of the use status of the device provided by the present invention;

[0039] Figure 2 A functional structure diagram of the system provided by the present invention;

[0040] Figure 3 A schematic diagram of information interaction of the functional modules provided by the present invention;

[0041] Figure 4 The present invention provides a detection flow chart.

[0042] Reference numerals list

[0043] 100: auxiliary breathing apparatus; 110: respiratory sound collection unit; 120: inflatable clothing; 121: clothing; 1211: front of clothing; 1212: back of clothing; 122: inflatable airbag; 123: fluid supply unit; 200: information processing module; 300: inhalation drug delivery module; 310: driving unit; 320: atomization unit; 330: liquid medicine box; 331: first liquid medicine box; 332: second liquid medicine box; 340: scanning lens. DETAILED DESCRIPTION

[0044] The following is a detailed description with reference to the accompanying drawings.

[0045] In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance. In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "configured to", "provided with", "connected", etc. should be understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, or it can be the internal connection of two elements. "Several" means two or more, unless otherwise clearly and specifically limited. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0046] Example 1

[0047] This embodiment provides a system for evaluating the matching degree of nebulization speed, nebulized particles and nebulized drug ratio with the patient based on the real-time treatment effect represented by the results of the child's breath sound / lung sound signal feedback during nebulization.

[0048] This embodiment provides a system for evaluating the matching degree of atomization speed, atomization particles and atomization drug ratio with the patient based on the real-time treatment effect represented by the feedback results of the breath sound / lung sound signal of the adult patient when the adult patient with respiratory diseases is atomized. In particular, the system involved in this application is suitable for elderly people with a long history of home atomization.

[0049] Figure 2 The functional structure diagram of the system is shown. In the application, the auxiliary breathing device 100, the information processing module 200 and the inhalation drug delivery module 300 can establish a communication connection, such as data, signals and / or control signals, through a wireless network (such as Bluetooth, WIFI, NFC, infrared technology, etc.).

[0050] In one aspect, the present application relates to an assisted respirator 100. The assisted respirator 100 includes a respiratory sound collection unit 110 for collecting lung sounds / breathing sounds of a patient, and an inflatable garment 120 for assisting the patient in adjusting the respiratory frequency. Preferably, the assisted respirator 100 also includes a power supply unit for providing energy to the respiratory sound collection unit 110 and the inflatable garment 120, a communication module for receiving instructions sent by the information processing module 200, and a microprocessor for converting the data collected by the respiratory sound collection unit 110 to increase the speed at which the communication module presents data to the information processing module 200. The communication module can send the collected information to the information processing module 200 via a cable port, a wireless transmitter, or a combination of the above signal transmissions. Preferably, the information processing module 200 is integrated into the inhalation medication module 300, or integrated into the patient's handheld terminal, so that the patient can adjust the inhalation medication module 300 through a handheld terminal such as a mobile phone.

[0051] The respiratory sound collection unit 110 is provided with an auscultation collection circuit and a differential amplifier circuit. The setting method of the auscultation collection circuit and the differential amplifier circuit can be the collection circuit disclosed in the Chinese patent publication number CN217904638U.

[0052] like Figure 1 As shown, the inflatable garment 120 is configured as a garment 121 that can be worn on the patient's body, the garment 121 includes a garment front 1211, a garment back 1212, and at least an inflatable airbag 122 incorporated in or on the garment front 1211, the garment front 1211 and / or the garment back 1212 include a recess configured to be able to be pressed against the patient's body surface for placing the respiratory sound collection unit 110.

[0053] The clothing 121 can be configured as an inflatable vest or other clothing that can be fitted on the chest to produce a squeezing feeling on the patient's chest. The inflatable airbag 122 provided on the clothing 121 can generate a corresponding inflation or deflation program along with the patient's exhalation or inhalation action. When the patient is required to maintain an inhalation action, the inflatable airbag 122 is in a deflated state, allowing the patient to expand the chest cavity and / or the abdominal cavity. When the patient is required to maintain an exhalation action, the inflatable airbag 122 is in an inflated state, allowing the patient to contract the chest cavity and / or the abdominal cavity.

[0054] Specifically, the inflatable airbag 122 provided on the garment 121 needs to squeeze the patient's chest when inflated so that the patient's chest feels the squeezing feeling, or the inflatable airbag 122 is deflated to make the patient feel the relaxation of the chest, thereby ensuring that the patient can adjust the breathing frequency through perception.

[0055] When the inflatable airbag 122 is inflated so that the worn garment 121 is pressed against the patient's body surface, the respiratory sound collection unit 110 placed in the recess can at least collect the patient's bronchial respiratory sounds, alveolar respiratory sounds and / or bronchoalveolar respiratory sounds. Preferably, the garment 121 is provided with recesses at the upper, middle and lower parts of the midclavicular line of the patient; the upper and lower parts of the anterior axillary line; the upper and lower parts of the midaxillary line, or the garment 121 is provided with recesses corresponding to the auscultation array disclosed in the Chinese patent with the announcement number CN217904638U. Preferably, one respiratory sound collection unit 110 or multiple respiratory sound collection units 110 are placed in one recess. The respiratory sound collection unit 110 is flush with the surface of the garment 121. A connector for detachably connecting the respiratory sound collection unit 110 to the garment 121 is provided inside the recess. The connector can be a button, a hook, a magnetic button, a rack, a magic sticker, etc.

[0056] Another aspect of the present application is also related to an inhalation medication module 300. Figure 1 , Figure 2 As shown, the inhalation medication module 300 includes a driving unit 310, a drug liquid box 330 regulated by the driving unit 310, and an atomization unit 320 that converts the drug liquid into an aerosol.

[0057] The liquid medicine box 330 is connected to the atomization unit 320 through the driving unit 310, and is controlled by the driving unit 310 to adjust the amount and type of medicine flowing into the atomization unit 320. Preferably, the liquid medicine box 330 includes a first liquid medicine box 331 and a second liquid medicine box 332, and the first liquid medicine box 331 and the second liquid medicine box 332 can be regulated by the driving unit 310 to administer the medicine separately. Preferably, when mixed administration is required, the driving unit 310 can simultaneously control the medicines in the first liquid medicine box 331 and the second liquid medicine box 332 to flow into the atomization unit 320. It should be noted that the number of liquid medicine boxes 330 is not limited, and the first liquid medicine box 331 and the second liquid medicine box 332 are only a preferred embodiment. The number of liquid medicine boxes 330 of the present application can be set to two or more, and each can be independently controlled by the driving unit 310.

[0058] The atomizing unit 320 can be a device that changes the physical form of the liquid medicine by ultrasound or high-speed jetting, which can make the liquid medicine enter and spray out in the form of aerosol. Preferably, the atomizing unit 320 is configured as an ultrasonic device. The power of the atomizing unit 320 can be controlled and adjusted.

[0059] The driving unit 310 generates a corresponding liquid adjustment action when receiving the instruction transmitted by the communication module and sent by the information processing module 200 .

[0060] When the liquid medicine box 330 is a container based on manual addition of medicine by an operator as shown in the prior art, the drive unit 310 can be set as a pump, which can select the amount of liquid medicine to be sucked by adjusting the power. When there are two or more liquid medicine boxes 330, the pump of the drive unit 310 can be set corresponding to each liquid medicine box 330, or a controlled valve can be set between each liquid medicine box 330 and the atomization unit 320. The liquid medicine transmission speed / transmission amount of different liquid medicine boxes 330 can be adjusted by adjusting the power of the pump and the opening and closing of the valve.

[0061] Furthermore, considering that nebulization therapy is a course-based approach, the patient needs to clean the medicine box 330 each time nebulization is performed. The present application provides a disposable medicine bottle and an inhalation drug delivery module 300 used in conjunction with the medicine bottle.

[0062] like Figure 1As shown, the driving unit 310 includes a joint assembly disposed between the medicine liquid box 330 and the atomization unit 320. The medicine liquid box 330 is configured to be in a shape that can be engaged with a medicine bottle. The joint assembly is sleeved on the liquid outlet end of the medicine bottle, and an opening is opened at the liquid outlet end of the engaged medicine bottle by means of twisting, acupuncture, etc. Preferably, the joint assembly includes a needle and a suction pump. Under the adjustment of the information processing module 200, the needle can pierce the medicine bottle engaged in the medicine liquid box 330 and, under the action of the suction pump, allow the medicine liquid in the medicine bottle to flow into the atomization unit 320. The medicine liquid obtained by this method can avoid contamination caused by contact with the air.

[0063] According to a preferred embodiment, a scanning lens 340 is provided at the position of the medicine box 330 corresponding to the bottle body. When the medicine bottle is engaged with the medicine box 330, the scanning lens 340 confirms whether the medicine is correctly selected by obtaining the bottle body information or other information (such as a QR code) on the bottle body.

[0064] Another aspect of the present application relates to an information processing module 200. The information processing module 200 can be a smart phone, a smart watch or other wearable device, a tablet computer, a computer, a cloud server or other smart device with a CPU and a communication module, which can be worn on the body of the patient's guardian. When the guardian is not with the patient, a conscious adult patient can wear the nebulizer device by himself and confirm whether the medicine is added correctly based on the scanning lens 340. When the operating procedure is correct, the guardian can remotely control the system to start. The CPU receives the detection signal sent from the auxiliary respirator 100 through the communication module, and converts the detection signal into processable data for further generating a signal to control the inhalation medication module 300.

[0065] Alternatively, the information processing module 200 can be integrated into the assisted breathing apparatus 100 or the inhalation medication module 300. The patient can adjust the nebulization process based on lung sound / breath sound feedback during the nebulization process by operating the assisted breathing apparatus 100 or the inhalation medication module 300.

[0066] In this embodiment, the auxiliary breathing apparatus 100 is an inflatable vest as an example. Figure 1 As shown, after the patient wears the auxiliary breathing apparatus 100, the auxiliary breathing apparatus 100 is surrounded by the patient's chest cavity through connecting components such as buttons and zippers on the front.

[0067] After the system is awakened by external input information, the respiratory sound collecting unit 110 starts to collect the initial lung sounds / breath sounds of the patient before atomization.

[0068] After the patient correctly wears the inhalation medication module 300 through confirmation of external input information, the inhalation medication module 300 starts to work based on a preset program (for example, interferon and saline are mixed into the medicine box 330 and start working with 4μm atomized particles and a spray speed of 0.8mL / min).

[0069] The respiratory sound collection unit 110 processes the collected data through the microprocessor of the assisted respirator 100 and presents it to the communication module of the assisted respirator 100, and sends it to the communication module of the information processing module 200 through the communication module. The CPU of the information processing module 200 processes the relevant information, that is, generates information such as the patient's respiratory frequency and sputum wetness based on the ripple curve characteristics such as the tone of the respiratory sound / lung sound. The CPU generates at least three judgments by comparing the respiratory sounds / lung sounds sent at different time periods, including whether there is a need to terminate the nebulization and send an early warning broadcast instruction through the set voice broadcast unit; the coordination between the patient's respiratory frequency and the drug administration frequency of the inhalation drug administration module 300; whether the patient's worsening tendency of respiratory sounds / lung sounds is alleviated (for example: whether the duration of wheezing sound is reduced).

[0070] At the same time, based on the drug administration frequency of the inhalation drug administration module 300, the CPU can control the inflatable clothes 120 of the auxiliary respirator 100 to expand (inflate) or relax (deflate) in coordination with the preset time value through the communication module of the auxiliary respirator 100. For example: when the inhalation drug administration module 300 sprays the drug to the patient's mouth and nose, based on the transmission time of the drug in the pipeline, the CPU lags 0.5s to control the relaxation of the inflatable clothes 120, so as to correct the time error caused by the coordinated operation of the patient's inhalation action and the nebulizer drug administration action caused by the atomization transmission, and ensure that the patient's inhalation and drug administration are carried out synchronously. At the same time, the time when the inflatable clothes 120 relaxes is the time when the inhalation drug administration module 300 administers the drug. For example: the inhalation drug administration module 300 sprays the drug for 3s, the inflatable clothes 120 continues to relax for 3s, and continues to inflate for 3s when the inhalation drug administration module 300 stops administering the drug, so that the patient continues to exhale within the 3s time when the inflatable clothes 120 is inflated.

[0071] Example 2

[0072] This embodiment provides a method for adjusting the respiratory frequency by atomization drug delivery. Figure 4 In this embodiment, except that the information processing module 200 controls the inhalation medication module 300 in a different manner, other hardware is the same as the previous embodiment.

[0073] Based on the correlation analysis between the breath sound / lung sound signal collected by the assisted ventilator 100 and the drug flow data, the information processing module 200 generates an adjustment instruction on the breathing mode, such as Figure 3 shown.

[0074] Based on the frequency of the breath sound / lung sound signal collected by the assisted ventilator 100, an atomization flow rate adjustment instruction related to the patient's breathing frequency adjustment is generated, such as Figure 3 shown.

[0075] Specifically, the information processing module 200 obtains the patient's respiratory frequency based on the time series data of the respiratory sounds collected by the respiratory sound collecting unit 110 , and matches it with the drug supply frequency of the inhalation drug delivery module 300 .

[0076] When the patient's breathing frequency does not match the medication supply frequency, the inflatable clothing 120 starts to work.

[0077] The fluid supply unit 123 inflates and deflates the inflatable airbag 122 of the garment 121 at the same frequency as the drug supply frequency. After feeling the squeezing and relaxation of the garment 121, the patient wearing the garment 121 can synchronously adjust his breathing frequency, so that the patient's breathing can autonomously match the drug supply frequency, thereby achieving the optimal drug supply effect.

[0078] At the same time, considering that the inhalation drug delivery module 300 delivers drugs to the patient in the form of pipelines, therefore, adjusting the drug delivery frequency and the breathing frequency to be consistent in time will cause errors in the drug flow time through the pipeline and the time of airflow transmission when the patient breathes, resulting in the patient's inhalation action and the inhalation drug delivery module 300 drug delivery action not matching. The information processing module 200 can control the auxiliary respirator 100 to generate corresponding breathing prompts at a preset time ahead of the inhalation drug delivery module 300 drug delivery rhythm, so as to correct the time error caused by the coordination of the patient's inhalation action and the nebulizer drug delivery action caused by atomization transmission. Preferably, the preset time can be automatically adjusted when the device is used, that is, the preset time will also change with the change of the flow rate of the atomized drug. Generally speaking, the faster the flow rate, the shorter the preset time in the same pipeline.

[0079] Example 3

[0080] This embodiment provides a method for adjusting the ratio of atomized drugs by atomization. Figure 4 In this embodiment, except that the information processing module 200 controls the inhalation medication module 300 in a different manner, other hardware is the same as the previous embodiment.

[0081] Based on the correlation analysis between the breath sound / lung sound signal collected by the ventilator 100 and the drug flow data, the information processing module 200 generates an adjustment instruction on the atomized drug ratio, such as Figure 3 shown.

[0082] For patients with chronic obstructive pulmonary disease and other diseases that require long-term nebulization, the information processing module 200 involved in this application can be connected to the hospital information system to provide medical staff with the patient's lung sounds / breath sounds or provide medical staff with nebulization drug adjustment plans generated based on the patient's lung sounds / breath sounds during different nebulizations.

[0083] The information processing module 200 can confirm the atomization effect of the patient by analyzing the collected time series data of lung sounds / breathing sounds.

[0084] The information processing module 200 determines the drug matching degree in the aerosol therapy process by two judgment mechanisms: a and b:

[0085] a. After obtaining the breath sounds / lung sounds collected by the breath sound collection unit 110, the information processing module 200 confirms whether the patient has symptoms beyond the treatment capacity of the nebulized drug based on the preset standard parameters of the breath sounds / lung sounds.

[0086] b. After obtaining the breath sounds / lung sounds collected by the breath sound collection unit 110, the CPU of the information processing module 200 sends a query application to the database of the information processing module 200 to obtain the breath sound / lung sound data of at least one nebulization process of the patient that is closest in time to the current nebulization number;

[0087] By comparing the historical breath sound / lung sound data with the breath sound / lung sound data generated by the current nebulization, combined with the therapeutic ability of the nebulized drug, it is determined whether the patient's symptoms related to the therapeutic ability of the nebulized drug have been alleviated.

[0088] Preferably, considering the time effect of nebulization on the patient, the CPU can obtain the breath sound / lung sound data of the patient during nebulization three times.

[0089] For example, after the patient completes the fourth nebulization, the information processing module 200 performs judgments of procedure a and procedure b respectively based on the respiratory sound / lung sound data collected by the respiratory sound collection unit 110 .

[0090] Procedure a is the judgment of new symptoms. When the duration of the disease-related sound of the respiratory sound / lung sound collected by the respiratory sound collection unit 110 or the frequency response value of the main frequency is higher than the preset duration of the disease-related sound of the respiratory sound / lung sound or the frequency response value of the main frequency, and the symptom corresponding to the feature (such as bronchial spasm, respiratory tract stenosis) is not within the main treatment range of the atomized drug (such as ambroxol hydrochloride injection with mucus discharge promoting effect), the information processing module 200 generates a scheme to supplement the atomized drug related to the above-mentioned symptom (such as terbutaline sulfate atomized liquid that can dilate the bronchi and relieve bronchospasm) and presents it to the HIS system through the communication module. The medical staff confirms the feasibility of the scheme through the HIS system and feeds back to the information processing module 200. At the same time, the medical staff can also notify the patient or his guardian (the contact person retained in the HIS system) through the HIS system to go to the designated hospital to pick up the medicine. After the information processing module 200 obtains the authorization of the medical staff, it can send instructions for adjusting the relevant drugs to the inhalation medication module 300. That is, during the next nebulization, after the adjusted nebulized drugs (ambroxol hydrochloride injection, terbutaline sulfate nebulizer solution) are successfully scanned by the scanning lens 340 of the inhalation medication module 300, the inhalation medication module 300 provides nebulization treatment for the patient based on the drug ratio sent by the information processing module 200.

[0091] Procedure b is the judgment of the development of old symptoms. After obtaining the breath sounds / lung sounds collected by the breath sound collection unit 110, the CPU of the information processing module 200 sends a query application to the database of the information processing module 200 to obtain the breath sounds / lung sounds data of the patient in at least one atomization process that is closest to the current atomization number in time. By comparing the historical breath sounds / lung sounds data with the breath sounds / lung sounds data generated by the current atomization, combined with the therapeutic ability of the atomized drug, it is judged whether the symptoms related to the therapeutic ability of the patient and the atomized drug are relieved. When the frequency response value of the wet rales of this atomization is higher than the frequency response value of the wet rales of the last atomization, based on the problem of sputum accumulation in the lungs or respiratory tract associated with the wet rales, the information processing module 200 generates a plan to replace the liquid medicine with a mucus discharge promoting effect or increase the use of the ambroxol hydrochloride injection with a mucus discharge promoting effect, and presents it to the HIS system through the communication module. The medical staff confirms the feasibility of the plan through the HIS system and feeds back to the information processing module 200. When the implementation plan is confirmed to be a change of medicine, the medical staff can also notify the patient or his / her guardian (contact person retained in the HIS system) through the HIS system to go to the designated hospital to pick up the medicine. After the information processing module 200 obtains the authorization of the medical staff, it can send the instruction of the relevant drug adjustment to the inhalation medication module 300, that is, the next time the atomization is performed, after the adjusted atomized drug (for example: the amount of ambroxol hydrochloride injection is changed from 1mL to 2mL) is successfully scanned by the scanning lens 340 of the inhalation medication module 300, the inhalation medication module 300 provides atomization treatment for the patient based on the drug ratio sent by the information processing module 200.

[0092] Example 4

[0093] This embodiment provides a method for adjusting the ratio of atomized drugs by atomization. Figure 4 In this embodiment, except that the information processing module 200 controls the inhalation medication module 300 in a different manner, other hardware is the same as the previous embodiment.

[0094] Based on the correlation analysis between the breath sound / lung sound signal collected by the assisted respirator 100 and the drug flow data, the information processing module 200 generates an adjustment instruction on the atomization position, such as Figure 3 shown.

[0095] The prior art indicates that the size of aerosolized particles is the main factor affecting the attachment position of aerosolized drugs. Aerosolized particles with a diameter of more than 10 μm can only accumulate in the oral cavity. Aerosolized particles with a diameter of 5 to 10 μm can flow into the patient's throat. Aerosolized particles with a diameter of 3 to 5 μm can flow into the patient's lung parenchyma and bronchi. Aerosolized particles with a diameter of 1 to 3 μm can flow into the deep lungs of patients. Aerosolized particles with a diameter of less than 1 μm will be expelled with breathing.

[0096] The respiratory sound collection unit 110 involved in the present application can obtain the respiratory sounds of the patient's respiratory tract and the lung sounds of the lungs based on the auscultation collection circuits respectively arranged in the patient's upper respiratory tract and lungs. More specifically, the auscultation collection circuit can also obtain the patient's respiratory sounds and lung sounds at different positions on the patient's chest and back. For example: an auscultation collection circuit is arranged at the position of the supraclavicular fossa, the suprasternal fossa, the larynx and / or the 6-7 cervical joints to collect the respiratory sounds of different respiratory tract branches.

[0097] Even if atomized particles with a diameter of 3 to 5 μm are used, the depth of the location where the drug reaches will vary with individual differences (respiratory mucosal state, respiratory tract diameter, etc.). Based on the collected lung sounds / breathing sounds, this application can timely know the depth of the atomized drug in the patient's respiratory tract and lungs during the atomization process, so that the inhaled drug module can be more accurately adjusted within the preset atomized particle size range. The adjustment method includes changing the operating power of the atomization unit 320.

[0098] When the patient is nebulized, the sound of the atomized airflow will cause the breath sounds and lung sounds collected by the breath sound collection unit 110 to contain sounds with other frequency characteristics. Based on the sounds of this frequency characteristic collected at different locations, the information processing module 200 can obtain the depth of the atomized drug. Based on the patient's pre-set drug arrival depth (lung parenchyma), when only sounds that meet the frequency characteristics of the atomized airflow are detected at the lower bronchus, the information processing module 200 can control the atomization unit 320 to adjust the operating power to reduce the size of the atomized particles by one unit. Preferably, one unit is a preset value, which can change the diameter of the atomized particles by 0.5 μm.

[0099] Example 5

[0100] During continuous multiple nebulizations, the patient's lung breath sounds will change (for example, aggravate or alleviate), which can be reflected in the duration of the patient's wheezing sound and the main frequency of the wheezing sound. When the patient's trachea including bronchi, bronchioles or small bronchioles undergoes partial changes (blockage or worsening phlegm and dampness symptoms), the resistance of airflow through the above parts becomes greater, and therefore, the duration of the wheezing sound in the lung sounds will increase and the pitch of the wheezing sound will become higher.

[0101] According to a preferred embodiment, the respiratory sound collection units 110 are respectively arranged at positions corresponding to the main trachea, left bronchus, left lung, right lung and right bronchus of the patient. When the lung sound information collected by the respiratory sound collection units 110 at some positions shows abnormal changes, the information processing module 200 can control the respiratory sound collection units 110 at other positions to stop collecting information to increase the accuracy of information collection.

[0102] For example, when the pitch of the wheezing sound collected by the respiratory sound collection unit 110 disposed in the left bronchus of the patient increases during the nebulization process, the information processing module 200 adjusts the nebulization particle size or the nebulization flow rate based on the data indicating that the phlegm and dampness in the left bronchus are aggravated.

[0103] When the size of the atomized particles is consistent with the size of particles delivered to the bronchi, the information processing module 200 increases the atomization flow rate according to a preset threshold.

[0104] When the size of the atomized particles does not meet the size of particles delivered to the bronchi, the information processing module 200 adjusts the power of the atomization unit 320 to make the size of the atomized particles meet the size of particles delivered to the bronchi.

[0105] The system involved in the present application opens the collection channels of specific parts according to different symptoms to obtain more accurate adjustment effects and prevent interference from signals in other parts.

[0106] It should be noted that the above-mentioned specific embodiments are exemplary, and those skilled in the art can come up with various solutions inspired by the disclosure of the present invention, and these solutions also belong to the disclosure scope of the present invention and fall within the protection scope of the present invention. Those skilled in the art should understand that the present invention specification and its drawings are illustrative and do not constitute a limitation of the claims. The scope of protection of the present invention is defined by the claims and their equivalents. The present invention specification contains multiple inventive concepts, such as "preferably", "according to a preferred embodiment" or "specifically", all of which indicate that the corresponding paragraph discloses an independent concept, and the applicant reserves the right to file a divisional application based on each inventive concept. Throughout the text, the features guided by "preferably" are only an optional method and should not be understood as being required. Therefore, the applicant reserves the right to abandon or delete the relevant preferred features at any time.

Claims

1. A real-time atomization treatment effect evaluation system, comprising: An inhalation drug administration module (300) is configured to provide a patient with a drug to be administered through the respiratory tract in an atomized manner, and is provided with a flow detection device to obtain time-related drug flow data when the patient uses the drug; An auxiliary respirator (100) comprising a respiratory sound collection unit (110) for collecting lung sounds / respiratory sounds of a patient and an inflatable garment (120) worn on the patient's body for assisting the patient in regulating respiratory frequency, the auxiliary respirator (100) being configured to be attached to the body surface of the patient's respiratory tract area, collecting time-related respiratory sound / lung sound signals when the patient is in use, wherein: The respiratory sound collection unit (110) is arranged on the inflatable garment (120); The information processing module (200) generates instructions for adjusting the inhalation medication module (300) based on the information collected by the auxiliary breathing device (100), characterized in that: Based on the correlation analysis between the breath sound / lung sound signal collected by the auxiliary breathing device (100) and the drug flow data, the information processing module (200) generates adjustment instructions on the atomization position, breathing mode and / or atomization drug ratio; The information processing module (200) obtains the patient's respiratory frequency based on the time series data of the respiratory sounds collected by the respiratory sound collection unit (110), and matches it with the drug supply frequency of the inhalation drug delivery module (300). When the patient's respiratory frequency does not match the drug supply frequency, the inflatable clothing (120) starts working, and the fluid supply unit (123) inflates and deflates the inflatable airbag (122) of the inflatable clothing (120) at the same frequency as the drug supply frequency.

2. The atomization real-time treatment effect evaluation system according to claim 1, characterized in that: The information processing module (200) is configured to: Based on the frequency of the breath sound / lung sound signal collected by the auxiliary breathing device (100), an atomization flow rate adjustment instruction related to the patient's breathing frequency adjustment is generated.

3. The atomization real-time treatment effect evaluation system according to claim 1 or 2, characterized in that: The information processing module (200) is configured to: Based on the intensity of the breath sound / lung sound signal collected by the auxiliary breathing device (100), an atomized particle adjustment instruction related to the change of the patient's sputum and dampness symptoms is generated.

4. The atomization real-time treatment effect evaluation system according to claim 1, characterized in that: The information processing module (200) is configured to: Based on abnormal changes in the breath sound / lung sound signals collected by the auxiliary breathing device (100), an adjustment instruction is generated to alleviate abnormal symptoms of the patient caused by the influence of atomization.

5. The atomization real-time treatment effect evaluation system according to claim 1, characterized in that: The information processing module (200) is configured to: The device is connected to a remote medical care terminal, and when the remote medical care terminal receives a single or multiple breath sound / lung sound signal of a patient collected by the auxiliary breathing device (100), the inhalation drug administration module (300) is controlled to adjust the drug ratio of the patient's atomization based on the drug ratio instruction sent by the remote medical care terminal.

6. The atomization real-time treatment effect evaluation system according to claim 1, characterized in that: The assisted breathing apparatus (100) comprises a respiratory sound collecting unit (110) capable of collecting lung sounds / respiratory sounds of a patient.

7. The atomization real-time treatment effect evaluation system according to claim 6, characterized in that: The inflatable garment (120) is configured as a garment (121) that can be worn on the patient's body, the garment (121) includes a garment front (1211), a garment back (1212), and at least an inflatable airbag (122) incorporated in or on the garment back (1212), the garment front (1211) and / or the garment back (1212) including a recess configured to be pressed against the patient's body surface for placing the respiratory sound collection unit (110).

8. The atomization real-time treatment effect evaluation system according to claim 7, characterized in that: When the inflatable airbag (122) is inflated so that the worn garment (121) is pressed against the patient's body surface, the respiratory sound collection unit (110) placed in the recess is capable of collecting at least the patient's bronchial respiratory sounds, alveolar respiratory sounds and / or bronchoalveolar respiratory sounds.

9. The atomization real-time treatment effect evaluation system according to claim 1, characterized in that: The inhalation drug delivery module (300) comprises a driving unit (310), a medicine liquid box (330) regulated by the driving unit (310), and an atomization unit (320) for converting the medicine liquid into an aerosol, wherein the driving unit (310) comprises a joint assembly arranged between the medicine liquid box (330) and the atomization unit (320), and the joint assembly comprises a needle and a suction pump, and under the regulation of the information processing module (200), the needle can pierce the medicine bottle engaged in the medicine liquid box (330), and under the action of the suction pump, the medicine liquid in the medicine bottle flows into the atomization unit (320).

10. The atomization real-time treatment effect evaluation system according to claim 9, characterized in that: The drug liquid box (330) comprises a first drug liquid box (331) and a second drug liquid box (332), and the first drug liquid box (331) and the second drug liquid box (332) can be independently regulated by the driving unit (310) to administer drugs.

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