Anti-wrinkle and firming cream with physalis

Abstract

The present invention provides an anti-wrinkle and firming facial cream containing bosine, comprising the following raw materials by mass fraction: bosine 8-10%, ectoine 0.06-0.12%, ergothioneine 0.17-0.23%, firming composition 2.2-2.8%, anti-wrinkle component 1.1-1.7%, emulsifier 1.9-2.6%, emollient grease 1.4-2.3%, glycerol 2.2-2.6%, 1,2-pentanediol 0.32-0.66%, 1,2-hexanediol 0.52-0.62%, preservative 0.10-0.15%, pH regulator 0.2-0.23% and thickener 0.21-0.25%, the remainder being water. The present invention provides an anti-wrinkle and firming facial cream containing bosine, which has good anti-wrinkle and firming effects through compounding of multiple raw materials, high stability of the facial cream, and good long-term use effects.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and in particular relates to an anti-wrinkle and firming facial cream containing benzoyl peroxide. Background Art

[0002] Pro-Xylane, also known as Hydroxypropyl Tetrahydropyrantriol, is a xylose derivative derived from the beech tree. It is a mixture of glycoproteins with anti-aging activity. Pro-Xylane is widely recognized as an effective anti-aging ingredient in the cosmetics industry and is often used in products of high-end skin care brands.

[0003] The cost of phosgene is relatively high, and there are still some problems in how to maximize the effect of phosgene in cosmetics, such as: (1) Stability issues: As an active ingredient, the stability of phosgene in the formula is crucial. It is still affected by oxidation, light, and temperature, which leads to a weakening of the product effect during use. (2) Formula compatibility: phosgene may require a specific formula environment to achieve the best effect. Certain ingredients in existing products may interact with phosgene, affecting its activity or causing irritation to the skin. (3) Permeability: Although phosgene can help the absorption of other ingredients, its own skin permeability is also key. Improving the effect of phosgene penetrating the stratum corneum and increasing its efficacy are also issues that need to be addressed.

[0004] In order to improve the long-term stability of phosphatase in products, the existing technology encapsulates phosphatase through microencapsulation or liposome encapsulation, which can protect it from external factors such as oxygen, light and temperature, thereby improving its stability. However, in the microencapsulation process, it is difficult to ensure that the active ingredients are effectively encapsulated inside the microcapsule. Low encapsulation efficiency will cause some active ingredients to be unprotected, thereby reducing the overall stability. In addition, inappropriate release may cause the ingredients to be released too early or too late, affecting the efficacy of the product. The stability of the microcapsule itself is also a problem. This technology cannot meet the needs of the existing market.

[0005] Therefore, there is an urgent need for an anti-wrinkle and firming cream containing phospholipids, which can maintain a long-lasting anti-wrinkle and firming effect and has broad market prospects and use value. Summary of the invention

[0006] The object of the present invention is to provide an anti-wrinkle and firming facial cream containing bosacein.

[0007] In order to achieve the above object, the present invention provides the following technical solutions:

[0008] An anti-wrinkle and firming facial cream containing oxytocin, comprising the following raw materials in mass fractions: oxytocin 8-10%, ectoine 0.06-0.12%, ergothioneine 0.17-0.23%, a firming composition 2.2-2.8%, an anti-wrinkle component 1.1-1.7%, an emulsifier 1.9-2.6%, a moisturizing oil 1.4-2.3%, glycerin 2.2-2.6%, 1,2-pentanediol 0.32-0.66%, 1,2-hexanediol 0.52-0.62%, a preservative 0.10-0.15%, a pH regulator 0.2-0.23% and a thickener 0.21-0.25%, and the balance is water;

[0009] Wherein, the preparation method of the anti-wrinkle component is:

[0010] (1) Mixing Polygonatum sibiricum, Gentiana scabra, and barley malt (Hordeum vulgare) in a mass ratio of 1:(1.4-1.7):(0.2-0.6), and grinding to a particle size of less than 80-100 meshes to obtain a mixed micro powder;

[0011] (2) mixing 1 part by weight of the mixed micro powder, 8-10 parts by weight of water and 0.12-0.15 parts by weight of Lactobacillus plantarum, performing anaerobic fermentation at a fermentation temperature of 35-38° C. for 10-12 hours, and pasteurizing to obtain a first fermentation product;

[0012] (3) adding 0.22-0.25 parts by weight of the compound enzyme to the first fermentation product for enzymolysis at a temperature of 35-38° C. for 15-20 h, and pasteurizing to obtain a second fermentation product;

[0013] (4) Filter the second fermentation product using a 0.22 μm filter membrane, and concentrate and dry the filtrate to obtain an anti-wrinkle component.

[0014] Furthermore, the complex enzyme is a mixture of β-glucanase, cellulase and neutral protease in a mass ratio of 1: (1.5-1.7): (0.4-0.8).

[0015] The present invention provides an anti-wrinkle component, which has a synergistic effect with phosphatidylcholine and can improve the anti-wrinkle effect of a facial cream. The active ingredients contained in the anti-wrinkle component have an anti-wrinkle effect and can have a synergistic effect with phosphatidylcholine. At the same time, polygonatum sibiricum, gentian root and barley malt themselves contain rich antioxidants, which can remove free radicals and prevent phosphatidylcholine from oxidative damage, thereby enhancing the long-term use effect of the overall formula. However, adding the anti-wrinkle component will cause the storage stability of the facial cream to decrease and a stratification phenomenon to occur, which may be caused by the poor compatibility of the anti-wrinkle component in the system.

[0016] Further, the firming composition comprises the following components in parts by mass: 1-3 parts of Sanguisorba officinalis extract, 7-11 parts of Adansonia digitata extract, 3-6 parts of Prunus serrulata extract and 5-8 parts of Avena sativa extract.

[0017] The present invention improves the skin tightening effect of the facial cream by adding a firming composition. The firming composition contains ingredients that promote collagen synthesis and is rich in antioxidants that can resist free radicals and reduce the damage of oxidative stress to the skin, thereby maintaining the elasticity and firmness of the skin. At the same time, the addition of the firming composition can also improve the storage stability of the cream after adding the anti-wrinkle component.

[0018] Furthermore, the mass ratio of the bosogenin, the firming composition and the anti-wrinkle component is 1:(2.3-2.6):(1.3-1.5).

[0019] After the cover is opened, the anti-wrinkle and firming effect of the phosphene added to the cream decreases after long-term use. The phosphene is exposed to the air, especially to oxygen, light and heat, which will reduce its activity, thereby weakening its original anti-wrinkle and firming effects. And after opening the cover for use, the cream is easily contaminated by microorganisms brought in by fingers, and the growth of microorganisms can decompose or consume the phosphene, thereby reducing its effect. The moisture in the cream will gradually evaporate, resulting in changes in the texture of the product, and will also affect the stability of the phosphene. In the cream of the present invention, when the phosphene, the firming composition and the anti-wrinkle component are compounded in a specific ratio, the problem of the decreased use effect of the phosphene caused by the change of the external environment can be improved, and the good use effect can still be maintained after long-term use, and the anti-wrinkle and firming effect of the cream is more significant. The active components in the firming composition and the anti-wrinkle component will produce a synergistic effect, enhance the stability and efficacy of the entire formula, and work together through different mechanisms to provide multi-layer protection, further improving the stability of the phosphene.

[0020] Furthermore, the emollient oil is a mixture of petrolatum, shea butter and squalane in a mass ratio of 1:(0.3-0.7):(1.5-1.8).

[0021] Furthermore, the emulsifier is a mixture of PEG-10 stearate, glyceryl isostearate and pentaerythritol distearate in a mass ratio of (1.2-1.4):1:(0.5-0.7).

[0022] Furthermore, the preservative is p-hydroxyacetophenone.

[0023] Furthermore, the pH adjuster is at least one of triethanolamine, arginine and sodium hydroxide.

[0024] Furthermore, the thickener is at least one of Carbomer 980, Carbomer 934, and Carbomer 941.

[0025] Furthermore, the preparation method of the anti-wrinkle and firming cream is:

[0026] S1: Heat and stir the emulsifier and emollient oil at 72-77°C to obtain a phase A solution;

[0027] S2: Mix the remaining components and stir at 45-50°C until all dissolved to obtain a phase B solution;

[0028] S3: Slowly add the phase A solution into the phase B solution, homogenize and emulsify, mix evenly, and obtain an anti-wrinkle and firming facial cream containing benzoyl peroxide.

[0029] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0030] 1. The present invention provides an anti-wrinkle and firming facial cream containing bosacein, which has good anti-wrinkle and firming effects through compounding of multiple raw materials, and the facial cream has high stability and good effects of long-term use.

[0031] 2. The present invention provides an anti-wrinkle component, which has a synergistic effect with physalis to improve the anti-wrinkle effect of the cream. The active ingredients contained in the anti-wrinkle component have an anti-wrinkle effect and can have a synergistic effect with physalis. At the same time, polygonatum, gentian root and barley malt themselves contain rich antioxidants, which can remove free radicals and prevent oxidative damage of physalis, thereby enhancing the long-term use effect of the overall formula.

[0032] 3. The present invention improves the skin tightening effect of the cream by adding a firming composition. The firming composition contains ingredients that promote collagen synthesis and is rich in antioxidants that can resist free radicals and reduce the damage of oxidative stress to the skin, thereby maintaining the elasticity and firmness of the skin. At the same time, the addition of the firming composition can also improve the storage stability of the cream after adding the anti-wrinkle component.

[0033] 4. When Bossagra, firming composition and anti-wrinkle component are compounded in a specific ratio, the problem of decreased effect of Bossagra caused by changes in the external environment can be improved. Long-term use can still maintain a good effect, and the anti-wrinkle and firming effect of the cream is more significant. The active components in the firming composition and anti-wrinkle component will produce a synergistic effect, enhance the stability and efficacy of the entire formula, and work together through different mechanisms to provide multi-layer protection and further improve the stability of Bossagra. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] The strains used in the present invention are all commercially available products, and the information is as follows:

[0036] Lactobacillus plantarum, deposit number: CCTCC CB 20081798, deposited in China Center for Type Culture Collection.

[0037] Lactobacillus casei, deposit number: CCTCC AB 2013131, deposited in China Center for Type Culture Collection.

[0038] β-Glucanase, enzyme activity 40u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0039] Cellulase, enzyme activity 50u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0040] Neutral protease, enzyme activity 100u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0041] Pectinase, enzyme activity 50u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0042] Bromelain, enzyme activity 300u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0043] Fig proteinase, enzyme activity 300u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0044] Sanguisorba officinalis extract, Shanxi Yuning Biotechnology Co., Ltd.

[0045] Baobab fruit extract, Xi'an Kangnuo Chemical Co., Ltd.

[0046] Black cherry bark extract, Wuhan Kemik Biopharmaceutical Technology Co., Ltd.

[0047] Oat bran extract, Lanzhou Waterless Biotechnology Co., Ltd.

[0048] Example 1

[0049] This embodiment provides an anti-wrinkle and firming facial cream containing oxytocin, comprising the following raw materials by mass fraction: 10% oxytocin, 0.08% ectoine, 0.21% ergothioneine, 2.5% firming composition, 1.4% anti-wrinkle component, 2.3% emulsifier, 1.9% emollient oil, 2.4% glycerol, 0.55% 1,2-pentanediol, 0.58% 1,2-hexanediol, 0.12% preservative, 0.22% pH regulator and 0.23% thickener, and the balance is water;

[0050] Wherein, the preparation method of the anti-wrinkle component is:

[0051] (1) Mixing polygonatum sibiricum, gentian root and barley malt in a mass ratio of 1:1.5:0.4, and grinding to a particle size of less than 90 meshes to obtain a mixed fine powder;

[0052] (2) mixing 1 part by weight of the mixed micro powder, 9 parts by weight of water and 0.14 parts by weight of Lactobacillus plantarum, performing anaerobic fermentation at a fermentation temperature of 37° C. for 11 h, and pasteurizing to obtain a first fermentation product;

[0053] (3) adding 0.24 parts by weight of compound enzyme to the first fermentation product for enzymolysis at a temperature of 37° C. for 18 h, and pasteurizing the product to obtain a second fermentation product;

[0054] (4) Filter the second fermentation product using a 0.22 μm filter membrane, and concentrate and dry the filtrate to obtain an anti-wrinkle component.

[0055] The complex enzyme is a mixture of beta-glucanase, cellulase and neutral protease in a mass ratio of 1:1.6:0.7.

[0056] The firming composition comprises the following components in parts by mass: 2 parts of Sanguisorba officinalis extract, 9 parts of Adansonia digitata pulp extract, 5 parts of Prunus nigra bark extract and 7 parts of oat bran extract.

[0057] The moisturizing oil is a mixture of petrolatum, shea butter and squalane in a mass ratio of 1:0.5:1.6.

[0058] The emulsifier is a mixture of PEG-10 stearate, glyceryl isostearate and pentaerythritol distearate in a mass ratio of 1.3:1:0.6.

[0059] The preservative is p-hydroxyacetophenone.

[0060] The pH adjuster is arginine.

[0061] The thickener is Carbomer 980.

[0062] The preparation method of the anti-wrinkle and firming facial cream is as follows:

[0063] S1: Heat and stir the emulsifier and emollient oil at 75°C to obtain a phase A solution;

[0064] S2: Mix the remaining components and stir at 47°C until all dissolved to obtain a phase B solution;

[0065] S3: Slowly add the phase A solution into the phase B solution, homogenize and emulsify, mix evenly, and obtain an anti-wrinkle and firming facial cream containing benzoyl peroxide.

[0066] Example 2

[0067] This embodiment provides an anti-wrinkle and firming facial cream containing bosacein, comprising the following raw materials by mass fraction: bosacein 9%, ectoine 0.06%, ergothioneine 0.23%, a firming composition 2.6%, an anti-wrinkle component 1.5%, an emulsifier 1.9%, a moisturizing oil 2.3%, glycerin 2.6%, 1,2-pentanediol 0.32%, 1,2-hexanediol 0.62%, a preservative 0.10%, a pH regulator 0.23% and a thickener 0.21%, and the balance is water;

[0068] Wherein, the preparation method of the anti-wrinkle component is:

[0069] (1) Mixing polygonatum sibiricum, gentian root and barley malt in a mass ratio of 1:1.4:0.3, and grinding to a particle size of less than 90 meshes to obtain a mixed fine powder;

[0070] (2) mixing 1 part by weight of the mixed micro powder, 10 parts by weight of water and 0.12 parts by weight of Lactobacillus plantarum, performing anaerobic fermentation at a fermentation temperature of 38° C. for 10 hours, and pasteurizing to obtain a first fermentation product;

[0071] (3) adding 0.25 parts by weight of the compound enzyme to the first fermentation product for enzymolysis at a temperature of 35° C. for 20 h, and pasteurizing the product to obtain a second fermentation product;

[0072] (4) Filter the second fermentation product using a 0.22 μm filter membrane, and concentrate and dry the filtrate to obtain an anti-wrinkle component.

[0073] The complex enzyme is a mixture of beta-glucanase, cellulase and neutral protease in a mass ratio of 1:1.5:0.8.

[0074] The firming composition comprises the following components in parts by mass: 3 parts of Sanguisorba officinalis extract, 7 parts of Adansonia digitata pulp extract, 6 parts of Prunus nigra bark extract and 5 parts of oat bran extract.

[0075] The moisturizing oil is a mixture of petrolatum, shea butter and squalane in a mass ratio of 1:0.3:1.5.

[0076] The emulsifier is a mixture of PEG-10 stearate, glyceryl isostearate and pentaerythritol distearate in a mass ratio of 1.4:1:0.5.

[0077] The preservative is p-hydroxyacetophenone.

[0078] The pH adjuster is arginine.

[0079] The thickener is Carbomer 941.

[0080] The preparation method of the anti-wrinkle and firming facial cream is as follows:

[0081] S1: Heat and stir the emulsifier and emollient oil at 77°C to obtain a phase A solution;

[0082] S2: Mix the remaining components and stir at 45°C until all dissolved to obtain a phase B solution;

[0083] S3: Slowly add the phase A solution into the phase B solution, homogenize and emulsify, mix evenly, and obtain an anti-wrinkle and firming facial cream containing benzoyl peroxide.

[0084] Comparative Example 1

[0085] The difference between this comparative example and Example 1 is that the mass ratio of polygonatum sibiricum, gentian root and barley malt is 1:1:1.

[0086] Comparative Example 2

[0087] The difference between this comparative example and Example 1 is that Lactobacillus plantarum is replaced by Lactobacillus casei.

[0088] Comparative Example 3

[0089] The difference between this comparative example and Example 1 is that the composite enzyme is a mixture of β-glucanase, cellulase and neutral protease in a mass ratio of 1:1:1.

[0090] Comparative Example 4

[0091] The difference between this comparative example and Example 1 is that the composite enzyme is a mixture of pectinase, bromelain and ficin in a mass ratio of 1:1.6:0.7.

[0092] Comparative Example 5

[0093] The difference between this comparative example and Example 1 is that the preparation method of the anti-wrinkle component is:

[0094] (1) Mixing polygonatum sibiricum, gentian root and barley malt in a mass ratio of 1:1.5:0.4, and grinding to a particle size of less than 90 meshes to obtain a mixed fine powder;

[0095] (2) 1 part by mass of the mixed micro powder and 12 parts by mass of an 80 wt% ethanol aqueous solution were mixed, refluxed for extraction for 5 hours, filtered using a 0.22 μm filter membrane, and the filtrate was concentrated and dried to obtain an anti-wrinkle component.

[0096] Comparative Example 6

[0097] The difference between this comparative example and Example 1 is that the firming composition comprises the following components in parts by weight: 7 parts of Sanguisorba officinalis extract, 5 parts of Adansonia digitata pulp extract, 9 parts of Prunus nigra bark extract and 2 parts of oat bran extract.

[0098] Comparative Example 7

[0099] The difference between this comparative example and Example 1 is that the mass fractions of the following raw materials in the anti-wrinkle and firming cream containing benzoin are different: 10% benzoin, 2.6% firming composition, and 1.5% anti-wrinkle component are replaced with 6% benzoin, 4.6% firming composition, and 3.5% anti-wrinkle component.

[0100] Performance Testing

[0101] 1. Antioxidant capacity test and anti-wrinkle test

[0102] Testers: 180 volunteers aged 23-60 years old; the volunteers were divided into 9 groups, 20 in each group, and the initial skin wrinkle conditions in each group were made as similar as possible, and the anti-wrinkle ability of the creams of Examples 1-2 and Comparative Examples 1-7 was tested respectively.

[0103] The antioxidant capacity test uses the ORAC method (oxidative radical absorption capacity), which is also called antioxidant capacity. The ORAC method is based on the principle that free radicals damage fluorescent probes and cause changes in fluorescence intensity. Trolox, a water-soluble analog of vitamin E, is used as a quantitative standard and analyzed using a fluorescent microplate analyzer. The change in fluorescence intensity reflects the degree of free radical damage. When an antioxidant is present, it can inhibit the fluorescence change caused by free radicals. The degree of inhibition reflects its antioxidant capacity against free radicals. The higher the ORAC content, the stronger the antioxidant capacity to inhibit free radicals.

[0104] The anti-wrinkle test uses the VISIA-CR facial skin image analyzer, which uses multispectral imaging technology to provide quantitative data to analyze changes in skin conditions. Wrinkle reduction rate = (baseline measurement value - follow-up measurement value) / baseline measurement value × 100%. Observe the wrinkle depth analysis of the skin, the wrinkle reduction rate, and measure the change rate after 28 days.

[0105] Table 1 Performance test results

[0106]

[0107]

[0108] 2. Firming effect test

[0109] The human zygomatic skin elasticity test method was used for evaluation. 180 volunteers, aged 23-60 years old, were divided into 9 groups, 20 in each group. The experimental method was as follows: the subjects washed their hands and faces, dried the epidermal moisture with disposable facial tissues, and then entered the test laboratory (temperature: 22±2℃, ambient humidity 55%) to sit for 10 minutes, and then used the skin elasticity test instrument MPA580 to test the skin elasticity value R, recorded the initial value T0, and then applied the cream of the embodiment and the comparative example to the zygomatic bone, and gently pressed with fingers, and then sat for 5 minutes to start measuring the skin elasticity change, the test time: the skin elasticity value R of 10 minutes, 2 hours, and 6 hours, and calculated △R=R-T0, the results are shown in Table 2.

[0110] Table 2 Compactness test results

[0111]

[0112]

[0113] 3. Stability test

[0114] The embodiments and comparative examples were placed in the following four environments for observation to test the material stability of the embodiments and comparative examples.

[0115] Normal temperature: The sample was placed at 25°C, 60% RH (relative humidity) for 3 months.

[0116] Cold resistance: -10℃ for 30 days.

[0117] Hot and cold cycle: 10℃, 25%RH; 25℃, 60%RH; 38℃, 75%RH, 24h at each temperature, 6 cycles in total.

[0118] High temperature acceleration: The test conditions are 50℃±1℃, 25%RH±5%RH for 30 days.

[0119] If there is no obvious change in the material, it is recorded as passed; if there is stratification or thinning, it is recorded as failed.

[0120] The results are shown in Table 3.

[0121] Table 3 Stability test results

[0122] Normal temperature appearance Cold resistant Hot and cold cycle high temperature Example 1 pass pass pass pass Example 2 pass pass pass pass Comparative Example 1 pass pass Not passed Not passed Comparative Example 2 Not passed pass Not passed Not passed Comparative Example 3 Not passed pass Not passed Not passed Comparative Example 4 Not passed pass Not passed Not passed Comparative Example 5 pass pass Not passed Not passed Comparative Example 6 Not passed pass Not passed Not passed Comparative Example 7 Not passed pass Not passed Not passed

[0123] From the above performance test results, it can be seen that the facial creams of Examples 1-2 have good anti-wrinkle and firming effects, especially the comprehensive performance of Example 1 is the most outstanding, which is mainly due to the good synergistic compounding effect of the components.

[0124] As can be seen from Table 1, the anti-wrinkle effect of the facial cream decreases when the preparation method or raw materials of the anti-wrinkle components of Comparative Examples 1-3 are changed. The mass ratio of Bose-1, firming composition and anti-wrinkle component of Comparative Example 7 is changed, and the anti-wrinkle effect of the facial cream is also decreased. Analysis shows that Bose-1 in the facial cream is oxidized and deteriorated due to long-term use of Bose-1, which affects the anti-wrinkle effect. As can be seen from Table 2, the raw material ratio of the firming composition of Comparative Example 5 is changed, and the firming effect decreases. At the same time, the firming effect of the facial cream of Comparative Example 7 is also decreased. As can be seen from Table 3, changing the composition and preparation method of the raw materials of the facial cream will change the long-term storage stability of the facial cream and affect the use effect. The above experimental results further demonstrate the importance of the technical scheme defined in the present invention for its technical effect.

[0125] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An anti-wrinkle and firming facial cream containing bosacein, characterized in that: The invention comprises the following raw materials in mass fractions: 8-10% of bosine, 0.06-0.12% of ectoine, 0.17-0.23% of ergothioneine, 2.2-2.8% of a firming composition, 1.1-1.7% of an anti-wrinkle component, 1.9-2.6% of an emulsifier, 1.4-2.3% of a moisturizing oil, 2.2-2.6% of glycerol, 0.32-0.66% of 1,2-pentanediol, 0.52-0.62% of 1,2-hexanediol, 0.10-0.15% of a preservative, 0.2-0.23% of a pH regulator and 0.21-0.25% of a thickener, and the balance is water; Wherein, the preparation method of the anti-wrinkle component is: (1) Mixing polygonatum sibiricum, gentian root and barley malt in a mass ratio of 1: (1.4-1.7): (0.2-0.6), and grinding to a particle size of less than 80-100 mesh to obtain a mixed micro powder; (2) mixing 1 part by weight of the mixed micro powder, 8-10 parts by weight of water and 0.12-0.15 parts by weight of Lactobacillus plantarum, performing anaerobic fermentation at a fermentation temperature of 35-38° C. for 10-12 hours, and pasteurizing to obtain a first fermentation product; (3) adding 0.22-0.25 parts by weight of the compound enzyme to the first fermentation product for enzymolysis at a temperature of 35-38° C. for 15-20 h, and pasteurizing to obtain a second fermentation product; (4) filtering the second fermentation product, concentrating and drying the filtrate to obtain an anti-wrinkle component; The complex enzyme is a mixture of β-glucanase, cellulase and neutral protease in a mass ratio of 1: (1.5-1.7): (0.4-0.8); The firming composition comprises the following components in parts by mass: 1-3 parts of Sanguisorba officinalis extract, 7-11 parts of Adansonia digitata pulp extract, 3-6 parts of Prunus nigra bark extract and 5-8 parts of oat bran extract.

2. The anti-wrinkle and firming facial cream containing bosine according to claim 1, characterized in that: The moisturizing oil is a mixture of petrolatum, shea butter and squalane in a mass ratio of 1: (0.3-0.7): (1.5-1.8).

3. The anti-wrinkle and firming facial cream containing bosine according to claim 1, characterized in that: The emulsifier is a mixture of PEG-10 stearate, glyceryl isostearate and pentaerythritol distearate in a mass ratio of (1.2-1.4):1:(0.5-0.7).

4. The anti-wrinkle and firming facial cream containing bosine according to claim 1, characterized in that: The preservative is p-hydroxyacetophenone.

5. The anti-wrinkle and firming facial cream containing bosine according to claim 1, characterized in that: The pH adjuster is at least one of triethanolamine, arginine and sodium hydroxide.

6. The anti-wrinkle and firming facial cream containing bosine according to claim 1, characterized in that: The thickener is at least one of Carbomer 980, Carbomer 934 and Carbomer 941.

7. A method for preparing the anti-wrinkle and firming facial cream containing bosine according to any one of claims 1 to 6, characterized in that: The preparation method is: S1: Heat and stir the emulsifier and emollient oil at 72-77°C to obtain a phase A solution; S2: Mix the remaining components and stir at 45-50°C until all dissolved to obtain a phase B solution; S3: Slowly add the phase A solution into the phase B solution, homogenize and emulsify, mix evenly, and obtain an anti-wrinkle and firming facial cream containing benzoyl peroxide.

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