Herbal fumigation moxibustion for strengthening spleen and clearing lungs and preparation method thereof

Abstract

The invention discloses a herbal fumigation and moxibustion for strengthening spleen and clearing lung and a preparation method thereof, and relates to the technical field of fumigation and moxibustion Chinese medicine materials, wherein the raw materials of the herbal fumigation and moxibustion include: loquat leaf, andrographis paniculata, Euryale ferox, tangerine peel, tangerine peel, Momordica grosvenori, Platycodon grandiflorum, Poria cocos, Eume, Chinese yam, Polygonatum odoratum, Lilium, Astragalus, Houttuynia cordata, Alpinia oxyphylla, Fritillaria cirrhosa, Ginkgo biloba, Coix seed, Codonopsis pilosula, Trichosanthes root, Fritillaria thunbergii, Radix Glycyrrhizae Preparata, Aucklandia lappa, Atractylodes macrocephala, Ophiopogon japonicus, Gynostemma pentaphyllum, Clove, Greater celandine and Gypsum. The herbal fumigation and moxibustion prepared by the invention is applied externally to the body surface, and the drug and acupoint efficacy are enhanced by enhancing the penetration of the prescription drug in contact with the acupoint skin, and at the same time, the drug smell enters the acupoint together with the heat after ignition, and then enters the meridians, and runs with the qi and blood, reaches the internal organs, and is spread all over the body, and can fully regulate the symptoms such as cough, sputum, and shortness of breath caused by people with lung and spleen qi deficiency constitution, thereby regulating the body function and improving the constitution.

Description

Technical Field

[0001] The invention relates to the technical field of fumigation-moxibustion Chinese medicinal materials, and in particular to a spleen-strengthening and lung-clearing herbal fumigation-moxibustion and a preparation method thereof. Background Art

[0002] Cough due to deficiency of lung and spleen qi. This syndrome is mostly caused by long-term illness, cough and asthma, which consumes lung qi. The child's illness affects the mother, affecting the spleen qi; or improper diet, which damages the spleen and stomach, and fails to produce metal, affecting the lung. Long-term illness, cough and asthma, lung qi deficiency, weakened respiratory function, dysfunction of descending and ascending, qi reversal, then coughing, shortness of breath and wheezing; lung qi deficiency, unable to transport and distribute water, accumulation of moisture to produce phlegm, so coughing up clear sputum; spleen qi deficiency, dysfunction of transportation and transformation, loss of appetite and less food intake, abdominal distension, loose stools; spleen deficiency, unable to transport and transform water, water vapor overflows the skin, then the face is puffy and the lower limbs are slightly swollen; qi deficiency reduces the function of the organs of the whole body, so there is less breath, lazy speech, fatigue and weakness; qi deficiency is unable to transport blood, the face is not nourished, then the face is pale and dull; pale tongue, white and slippery tongue coating, weak pulse are signs of qi deficiency.

[0003] In the prior art, most of the traditional Chinese medicine products for improving the physical condition of people with lung and spleen qi deficiency are taken orally. For example, the invention patent with publication number CN112602930A discloses a health drink with a traditional Chinese medicine formula, which has the effects of moistening the lungs, clearing the heart, and benefiting the spleen. However, the effect of regulating lung and spleen qi deficiency is unclear, and the clinical symptoms caused by lung and spleen qi deficiency are not significantly improved. In addition, due to the bitter taste of traditional Chinese medicine, it is difficult for patients to persist in taking it, and it is not suitable for actual promotion and application.

[0004] Fumigation moxibustion, also known as moxa fumigation, is a method of treating diseases by placing moxa sticks or moxa wool in a special container, lighting it, and then using the smoke to fumigate the affected area. It has obvious therapeutic effects on many diseases and plays a very important role in Chinese medicine. Fumigation moxibustion is widely spread among the people because of its advantages of low price, simple operation and easy mastery, and has made great contributions to people's disease prevention and treatment. However, there are no reports on the use of fumigation moxibustion to improve the symptoms of spleen and lung qi deficiency.

[0005] Therefore, how to provide a herbal fumigation moxibustion for strengthening the spleen and clearing the lungs is a problem that those skilled in the art need to solve urgently. Summary of the invention

[0006] In view of this, the present invention provides a spleen-strengthening and lung-clearing herbal fumigation and moxibustion and a preparation method thereof.

[0007] In order to achieve the above object, the present invention adopts the following technical solution:

[0008] A herbal fumigation for strengthening the spleen and clearing the lungs comprises the following raw materials: loquat leaf, andrographis paniculata, euryale ferox, tangerine peel, tangerine peel, monk fruit, platycodon, tuckahoe, black plum, yam, polygonatum, lily, astragalus, houttuynia cordata, alkyl oxyphylla, fritillaria cirrhosa, ginkgo, coix seed, codonopsis pilosula, trichosanthes root, fritillaria, roasted licorice, costusroot, atractylodes macrocephala, ophiopogon japonicus, gynostemma pentaphyllum, clove, celandine and gypsum.

[0009] Further, the following raw materials are included in parts by weight: 45-55 parts of loquat leaves, 40-55 parts of andrographis paniculata, 40-50 parts of Euryale ferox, 35-45 parts of orange peel, 30-45 parts of orange peel, 28-34 parts of Momordica grosvenori, 25-35 parts of Platycodon grandiflorum, 23-31 parts of Poria cocos, 22-30 parts of Prunus mume, 20-30 parts of Astragalus, 20-27 parts of Chinese yam, 19-26 parts of Polygonatum odoratum, 15-26 parts of Lilium, 15-26 parts of Houttuynia cordata, 15-24 parts of Alpinia oxyphylla, 14-20 parts of Fritillaria cirrhosa, 13-19 parts of Ginkgo, 13-19 parts of Coix seeds, 11-16 parts of Codonopsis pilosula, 10-16 parts of Trichosanthes, 8-14 parts of Fritillaria, 7-11 parts of Radix Glycyrrhizae Preparata, 5-11 parts of Costusroot, 5-11 parts of Atractylodes macrocephala, 3-10 parts of Ophiopogon japonicus, 3-10 parts of Gynostemma pentaphyllum, 3-8 parts of Clove, 3-8 parts of Chelidonium officinale and 1-5 parts of Gypsum.

[0010] Preferably, the following raw materials are included in parts by weight: 52 parts of loquat leaves, 55 parts of andrographis paniculata, 46 parts of Euryale ferox, 38 parts of orange peel, 30 parts of tangerine peel, 30 parts of momordica grosvenori, 32 parts of platycodon, 31 parts of tuckahoe, 27 parts of ebony, 23 parts of astragalus, 20 parts of yam, 21 parts of polygonatum, 23 parts of lily, 26 parts of houttuynia, 21 parts of alpinia oxyphylla, 16 parts of fritillaria cirrhosa, 13 parts of ginkgo, 15 parts of coix seeds, 15 parts of codonopsis pilosula, 16 parts of trichosanthes, 12 parts of fritillaria, 8 parts of roasted liquorice, 5 parts of costusroot, 7 parts of atractylodes macrocephala, 9 parts of ophiopogon, 10 parts of gynostemma pentaphyllum, 7 parts of cloves, 5 parts of celandine and 1 part of gypsum.

[0011] As the same inventive concept as the above technical solution, the present invention also claims protection for the preparation method of the above herbal fumigation moxibustion, comprising the following steps:

[0012] (1) Weigh the raw materials according to the above weight proportions and set aside;

[0013] (2) Grind loquat leaves, tangerine peel, monk fruit, platycodon, houttuynia cordata, trichosanthes, and licorice root, and pass through a 60-80 mesh sieve to obtain a mixed powder A. Add the mixed powder A to a methanol aqueous solution at a ratio of mixed powder A: methanol (m:v) = 1 g: 6-8 mL, stir evenly, perform water bath ultrasonic extraction, filter, centrifuge, and dry under reduced pressure to obtain extract I;

[0014] (3) Crush the raw materials of tangerine peel, black plum, Chinese yam, polygonatum odoratum, lily, coix seed and costusroot, and pass through a 60-80 mesh sieve to obtain a mixed powder B, add the mixed powder B into distilled water according to the ratio of mixed powder B: distilled water m:v=1g:8-10mL, stir evenly, add pectinase after preheating for ultrasonic enzymolysis, place in boiling water to inactivate the enzyme after completion, filter, centrifuge, and dry under reduced pressure to obtain extract II;

[0015] (4) Grind the raw materials of Andrographis paniculata, Codonopsis pilosula, Poria cocos, Astragalus membranaceus, Alpinia oxyphylla, Clove, and Greater celandine, and pass through a 60-80 mesh sieve to obtain a mixed powder C. Add the mixed powder A to an ethanol aqueous solution at a ratio of mixed powder A: ethanol m:v = 1 g: 2-4 mL, stir evenly, reflux extraction, collect the filtrate, centrifuge, and dry under reduced pressure to obtain extract III;

[0016] (5) Grind the raw materials of Euryale ferox, Fritillaria cirrhosa, Ginkgo biloba, Fritillaria thunbergii, Atractylodes macrocephala, Ophiopogon japonicus, Gynostemma pentaphyllum, and gypsum, and pass through a 60-80 mesh sieve to obtain a mixed powder D, add the mixed powder D into ethyl acetate in a ratio of mixed powder A: ethyl acetate m:v = 1 g: 10-12 mL, stir evenly, reflux extraction, combine the extracts and centrifuge, and dry under reduced pressure to obtain extract IV;

[0017] (6) After the extracts I-IV are mixed evenly, a mixed extract is obtained, and then yeast liquid and water are added for fermentation. After drying and sterilization, a mixture can be obtained.

[0018] Furthermore, in step (2), the volume concentration of the methanol aqueous solution is 68%-72%; the water bath temperature is 55-60°C, the ultrasonic power is 800-1000W, and the extraction time is 0.5-1h; the centrifugation is 500-1000rpm for 3-10min; and the drying is low-temperature drying.

[0019] Furthermore, in step (3), the preheating temperature is 40-50°C; the amount of pectinase added is 1-2% of the mass of the mixed powder B; the ultrasonic power is 600-800W, the enzymatic hydrolysis time is 50-60min; the enzyme inactivation time is 5-15min; and the centrifugation is 500-800rpm for 5-10min.

[0020] Furthermore, in step (4), the volume concentration of the ethanol aqueous solution is 90%-95%; the number of extractions is 2-4 times, and the extraction time is 1-2 hours per time; and the centrifugation is performed at 600-800 rpm for 10-15 minutes.

[0021] Furthermore, in step (5), the extraction times are 3-5 times, the extraction time is 6-8 hours / time; and the centrifugation is performed at 1000-1200 rpm for 1-5 minutes.

[0022] Furthermore, in step (6), the yeast culture liquid has a bacterial content of 2×10 8 -5×10 8 cfu / mL; the ratio of the mixed extract, yeast liquid and water is: (3-8) g: (2-5) mL: (50-100) mL; the fermentation is carried out at 25-35°C for 1-2 days.

[0023] Furthermore, in steps (2) to (6), the reduced pressure drying is performed at 30-50° C. for 48-60 hours until the water content is 3-5%.

[0024] As an inventive concept identical to the above technical solution, the present invention also requests protection for the use of the above herbal fumigation or the herbal fumigation prepared by the above method in the preparation of spleen-strengthening and lung-clearing medicines.

[0025] It can be seen from the above technical scheme that, compared with the prior art, the present invention discloses a herbal fumigation moxibustion for strengthening the spleen and clearing the lungs and a preparation method thereof, with beneficial effects:

[0026] The herbal fumigation of the present invention is applied externally on the body surface, and can enhance the permeability of the traditional Chinese medicine and the skin contacting the meridian points, with a large heating surface and a strong sensation, thereby enhancing the efficacy of the medicine and the acupoints. At the same time, the smell of the medicine enters the acupoints along with the heat after ignition, and then enters the meridians, and reaches the internal organs with the circulation of qi and blood, and is spread throughout the body. It can fully regulate the symptoms of cough, sputum, shortness of breath and the like caused by people with lung and spleen qi deficiency, thereby regulating the functions of the human body and improving the physical condition.

[0027] Compared with Chinese medicine taken orally, the herbal fumigation in the present invention is applied externally on the body surface, and most of them are absorbed through the skin and mucous membranes. The components of the medicine have been filtered through a barrier before entering the body, and the harmful components are also small and weakened, so the damage to the liver and kidneys is small; while Chinese medicine taken orally is absorbed into the blood through the gastrointestinal tract, and its metabolites, especially some toxic products, must be detoxified and decomposed by the liver and excreted through the kidneys, which causes greater damage to the liver and kidneys. In addition, the herbal fumigation of the present invention can be observed at any time during the external application process, and it is safe to use and has no side effects. DETAILED DESCRIPTION

[0028] The following will be described clearly and completely in conjunction with the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] Example 1

[0030] A herbal fumigation for invigorating the spleen and clearing the lungs, comprising the following raw materials in parts by weight: 45 parts of loquat leaves, 45 parts of andrographis paniculata, 50 parts of Euryale ferox, 41 parts of orange peel, 35 parts of orange peel, 28 parts of Momordica grosvenori, 28 parts of Platycodon grandiflorum, 29 parts of Poria cocos, 30 parts of Prunus mume, 26 parts of Astragalus, 23 parts of Dioscorea opposita, 19 parts of Polygonatum odoratum, 19 parts of Lilium, 23 parts of Houttuynia cordata, 24 parts of Alpinia oxyphylla, 18 parts of Fritillaria cirrhosa, 15 parts of Ginkgo, 13 parts of Coix seeds, 13 parts of Codonopsis pilosula, 14 parts of Trichosanthes, 14 parts of Fritillaria, 10 parts of Radix Glycyrrhizae Preparata, 7 parts of Aucklandia lappa, 5 parts of Atractylodes macrocephala, 5 parts of Ophiopogon japonicus, 7 parts of Gynostemma pentaphyllum, 8 parts of Caryophyllus caryophyllus, 7 parts of Celandine and 3 parts of Gypsum;

[0031] The preparation method is as follows:

[0032] (1) Weigh the raw materials according to the above weight proportions and set aside;

[0033] (2) The loquat leaves, tangerine peel, monk fruit, platycodon, houttuynia cordata, trichosanthes, and licorice were ground and passed through a 60-mesh sieve to obtain a mixed powder A. The mixed powder A was added to a methanol aqueous solution with a volume concentration of 65% according to the ratio of mixed powder A: methanol m:v = 1g:6mL, and the mixture was stirred evenly. The mixture was extracted in a water bath with ultrasonic wave at 58°C and 1000W for 0.7h, filtered, centrifuged at 500rpm for 10min, and dried under reduced pressure at 40°C for 54h to obtain extract I.

[0034] (3) Crush the raw materials of tangerine peel, black plum, yam, polygonatum, lily, coix seed and costus root, pass through a 70-mesh sieve to obtain a mixed powder B, add the mixed powder B into distilled water at a ratio of mixed powder B: distilled water (m:v=1g:8mL), stir evenly, preheat to 50°C, add 1.5% by mass pectinase (1500U / g), perform ultrasonic enzymolysis at 600W for 55min, place in boiling water for 15min to inactivate the enzyme, filter, centrifuge at 650rpm for 8min, and dry under reduced pressure at 50°C for 48h to obtain extract II;

[0035] (4) Crush the raw materials of Andrographis paniculata, Codonopsis pilosula, Poria cocos, Astragalus membranaceus, Alpinia oxyphylla, Clove, and Greater celandine, and pass through an 80-mesh sieve to obtain a mixed powder C. Add the mixed powder A to an ethanol aqueous solution with a volume concentration of 90% according to the ratio of mixed powder A: ethanol m:v = 1 g: 2 mL, stir evenly, reflux extraction 3 times, each time for 2 h, collect the filtrate, centrifuge at 700 rpm for 12 min, and dry under reduced pressure at 30°C for 60 h to obtain extract III;

[0036] (5) Grind the raw materials of Euryale ferox, Fritillaria cirrhosa, Ginkgo biloba, Fritillaria thunbergii, Atractylodes macrocephala, Ophiopogon japonicus, Gynostemma pentaphyllum, and gypsum, and pass through a 60-mesh sieve to obtain a mixed powder D. Add the mixed powder D into ethyl acetate at a ratio of mixed powder A: ethyl acetate m:v = 1 g: 10 mL, stir evenly, reflux and extract 4 times, each time for 8 h, combine the extracts, centrifuge at 1100 rpm for 3 min, and dry under reduced pressure at 50°C for 48 h to obtain extract IV;

[0037] (6) After extracts I-IV were mixed evenly, a mixed extract was obtained. Then, 3 g of the mixed extract was added with 1 mL of yeast solution (with a bacterial concentration of 2.17 × 10 8 cfu / mL) and 50mL of water were fermented at 25°C for 2d, dried under reduced pressure at 50°C for 48h until the water content was 5%, and sterilized to obtain a mixture.

[0038] Example 2

[0039] A herbal fumigation for invigorating the spleen and clearing the lungs, comprising the following raw materials in parts by weight: 52 parts of loquat leaves, 55 parts of andrographis paniculata, 46 parts of Euryale ferox, 38 parts of orange peel, 30 parts of tangerine peel, 30 parts of Momordica grosvenori, 32 parts of Platycodon grandiflorum, 31 parts of Poria cocos, 27 parts of Prunus mume, 23 parts of Astragalus, 20 parts of Dioscorea opposita, 21 parts of Polygonatum odoratum, 23 parts of Lilium, 26 parts of Houttuynia cordata, 21 parts of Alpinia oxyphylla, 16 parts of Fritillaria cirrhosa, 13 parts of Ginkgo, 15 parts of Coix seeds, 15 parts of Codonopsis pilosula, 16 parts of Trichosanthes kirilowii, 12 parts of Fritillaria, 8 parts of Radix Glycyrrhizae Preparata, 5 parts of Aucklandia lappa, 7 parts of Atractylodes macrocephala, 9 parts of Ophiopogon japonicus, 10 parts of Gynostemma pentaphyllum, 7 parts of Caryophyllus syringae, 5 parts of Greater celandine and 1 part of Gypsum;

[0040] The preparation method is as follows:

[0041] (1) Weigh the raw materials according to the above weight proportions and set aside;

[0042] (2) The loquat leaves, tangerine peel, monk fruit, platycodon, houttuynia cordata, trichosanthes, and licorice were ground and passed through a 70-mesh sieve to obtain a mixed powder A. The mixed powder A was added to a methanol aqueous solution with a volume concentration of 70% according to a ratio of mixed powder A: methanol m:v = 1 g: 8 mL, and the mixture was stirred evenly. The mixture was extracted in a water bath with ultrasonic wave at 60°C and 900 W for 0.5 h, filtered, centrifuged at 750 rpm for 7 min, and dried under reduced pressure at 30°C for 60 h to obtain extract I.

[0043] (3) Crush the raw materials of tangerine peel, black plum, yam, polygonatum, lily, coix seed and costus root, pass through an 80-mesh sieve to obtain a mixed powder B, add the mixed powder B into distilled water according to the ratio of mixed powder B: distilled water m:v=1g:9mL, stir evenly, preheat to 50°C, add 1% by mass pectinase (1500U / g), perform ultrasonic enzymolysis at 700W for 60min, place in boiling water for 10min to inactivate the enzyme, filter, centrifuge at 500rom for 10min, and dry under reduced pressure at 40°C for 54h to obtain extract II;

[0044] (4) Crush the raw materials of Andrographis paniculata, Codonopsis pilosula, Poria cocos, Astragalus membranaceus, Alpinia oxyphylla, Clove, and Greater celandine, and pass through a 60-mesh sieve to obtain a mixed powder C. Add the mixed powder A to an ethanol aqueous solution with a volume concentration of 93% according to the ratio of mixed powder A: ethanol m:v = 1g:3mL, stir evenly, reflux extraction 4 times, each time for 1.5h, collect the filtrate, centrifuge at 600rpm for 15min, and dry under reduced pressure at 50℃ for 48h to obtain extract III;

[0045] (5) Grind the raw materials of Euryale ferox, Fritillaria cirrhosa, Ginkgo biloba, Fritillaria thunbergii, Atractylodes macrocephala, Ophiopogon japonicus, Gynostemma pentaphyllum, and gypsum, and pass through a 70-mesh sieve to obtain a mixed powder D. Add the mixed powder D into ethyl acetate at a ratio of mixed powder A: ethyl acetate m:v = 1 g: 12 mL, stir evenly, and reflux extraction for 5 times, each time for 6 h. Combine the extracts, centrifuge at 1000 rpm for 5 min, and dry under reduced pressure at 30°C for 60 h to obtain extract IV.

[0046] (6) After extracts I-IV were mixed evenly, a mixed extract was obtained. Then, 5 g of the mixed extract was added with 3.5 mL of yeast culture solution (with a bacterial concentration of 3.57 × 10 8 cfu / mL) and 75mL of water were fermented at 35°C for 1d, dried under reduced pressure at 30°C for 60h until the water content was 3% and sterilized to obtain a mixture.

[0047] Example 3

[0048] A herbal fumigation for invigorating the spleen and clearing the lungs, comprising the following raw materials in parts by weight: 48 parts of loquat leaves, 50 parts of andrographis paniculata, 43 parts of Euryale ferox, 35 parts of tangerine peel, 40 parts of tangerine peel, 34 parts of Momordica grosvenori, 25 parts of Platycodon grandiflorum, 26 parts of Poria cocos, 22 parts of Prunus mume, 30 parts of Astragalus, 25 parts of Chinese yam, 26 parts of Polygonatum odoratum, 15 parts of Lilium, 19 parts of Houttuynia cordata, 15 parts of Alpinia oxyphylla, 20 parts of Fritillaria cirrhosa, 17 parts of Ginkgo, 19 parts of Coix seeds, 11 parts of Codonopsis pilosula, 12 parts of Trichosanthes, 8 parts of Fritillaria, 11 parts of Radix Glycyrrhizae Preparata, 9 parts of Aucklandia lappa, 11 parts of Atractylodes macrocephala, 3 parts of Ophiopogon japonicus, 5 parts of Gynostemma pentaphyllum, 3 parts of Clove, 8 parts of Chelidonium herb and 4 parts of Gypsum;

[0049] The preparation method is as follows:

[0050] (1) Weigh the raw materials according to the above weight proportions and set aside;

[0051] (2) The loquat leaves, tangerine peel, monk fruit, platycodon, houttuynia cordata, trichosanthes, and licorice were ground and passed through an 80-mesh sieve to obtain a mixed powder A. The mixed powder A was added to a methanol aqueous solution with a volume concentration of 72% according to a ratio of mixed powder A: methanol m:v = 1 g: 7 mL, and the mixture was stirred evenly. The mixture was extracted in a water bath with ultrasonic wave at 55°C and 800 W for 1 h. The mixture was filtered, centrifuged at 1000 rpm for 3 min, and dried under reduced pressure at 50°C for 48 h to obtain extract I.

[0052] (3) Crush the raw materials of tangerine peel, black plum, yam, polygonatum, lily, coix seed and costus root, pass through an 80-mesh sieve to obtain a mixed powder B, add the mixed powder B into distilled water according to the ratio of mixed powder B: distilled water m:v=1g:10mL, stir evenly, preheat to 40°C, add 2% by weight pectinase (1500U / g), perform ultrasonic enzymolysis at 800W for 50min, place in boiling water for 5min to inactivate the enzyme, filter, centrifuge at 800rom for 5min, and dry under reduced pressure at 30°C for 60h to obtain extract II;

[0053] (4) Crush the raw materials of Andrographis paniculata, Codonopsis pilosula, Poria cocos, Astragalus membranaceus, Alpinia oxyphylla, Clove, and Greater celandine, and pass through a 60-mesh sieve to obtain a mixed powder C. Add the mixed powder A to an ethanol aqueous solution with a volume concentration of 95% according to the ratio of mixed powder A: ethanol m:v = 1 g: 4 mL, stir evenly, reflux extraction twice, each time for 1 h, collect the filtrate, centrifuge at 800 rpm for 10 min, and dry under reduced pressure at 40°C for 54 h to obtain extract III;

[0054] (5) Grind the raw materials of Euryale ferox, Fritillaria cirrhosa, Ginkgo biloba, Fritillaria thunbergii, Atractylodes macrocephala, Ophiopogon japonicus, Gynostemma pentaphyllum, and gypsum, and pass through a 70-mesh sieve to obtain a mixed powder D. Add the mixed powder D into ethyl acetate at a ratio of mixed powder A: ethyl acetate m:v = 1 g: 11 mL, stir evenly, reflux extraction 3 times, each time for 7 h, combine the extracts, centrifuge at 1200 rpm for 1 min, and dry under reduced pressure at 40°C for 54 h to obtain extract IV;

[0055] (6) After extracts I-IV were mixed evenly, a mixed extract was obtained. Then, 8 g of the mixed extract was added with 5 mL of yeast solution (with a bacterial concentration of 4.83 × 10 8 cfu / mL) and 100 mL of water were fermented at 30°C for 1.5 d, dried under reduced pressure at 40°C for 54 h until the water content was 4% and sterilized to obtain a mixture.

[0056] Example 4

[0057] A herbal fumigation for invigorating the spleen and clearing the lungs, comprising the following raw materials in parts by weight: 55 parts of loquat leaves, 40 parts of andrographis paniculata, 40 parts of Euryale ferox, 45 parts of tangerine peel, 45 parts of tangerine peel, 32 parts of Momordica grosvenori, 35 parts of Platycodon grandiflorum, 23 parts of Poria cocos, 23 parts of Prunus mume, 20 parts of Astragalus, 27 parts of Dioscorea opposita, 24 parts of Polygonatum odoratum, 26 parts of Lilium, 15 parts of Houttuynia cordata, 18 parts of Alpinia oxyphylla, 14 parts of Fritillaria cirrhosa, 19 parts of Ginkgo, 17 parts of Coix seeds, 16 parts of Codonopsis pilosula, 10 parts of Trichosanthes, 10 parts of Fritillaria, 7 parts of Radix Glycyrrhizae Preparata, 11 parts of Aucklandia lappa, 9 parts of Atractylodes macrocephala, 10 parts of Ophiopogon japonicus, 3 parts of Gynostemma pentaphyllum, 5 parts of Clove, 3 parts of Chelidonium herba and 5 parts of Gypsum;

[0058] The preparation method is the same as that in Example 2.

[0059] Comparative Example 1

[0060] The composition in patent number CN107029146A is prepared into fumigation moxibustion by the preparation method of Example 2 of the present invention, and the specific method is as follows:

[0061] (1) Flos lonicerae, fructus momordicae, platycodon grandiflorum, houttuynia cordata, tangerine peel, perilla seed, and dandelion are ground and passed through an 80-mesh sieve to obtain a mixed powder A. The mixed powder A is added into a methanol aqueous solution having a volume concentration of 70% according to a ratio of mixed powder A:methanol (m:v) = 1 g:7 mL, and the mixture is stirred evenly. The mixture is extracted by ultrasonication in a water bath at 55° C. and 800 W for 1 h, filtered, centrifuged at 1000 rpm for 3 min, the supernatant is concentrated, and dried to obtain extract I;

[0062] (2) Crush the raw materials of tangerine peel, yam, polygonatum, lily, coix seed, almond and lotus seed, pass through an 80-mesh sieve to obtain a mixed powder B, add the mixed powder B into distilled water according to the ratio of mixed powder B: distilled water m:v=1g:10mL, stir evenly, preheat to 40°C, add 2% by weight pectinase (1500U / g), perform ultrasonic enzymolysis at 800W for 50min, place in boiling water for 5min to inactivate the enzyme, filter, centrifuge at 800rom for 5min, concentrate the supernatant, and dry at low temperature to obtain extract II;

[0063] (3) Grind the raw materials of Poria cocos, kelp, cloves and celandine, and pass through a 60-mesh sieve to obtain a mixed powder C. Add the mixed powder A to an ethanol aqueous solution with a volume concentration of 93% according to the ratio of mixed powder A: ethanol m:v = 1 g: 4 mL, stir evenly, reflux extraction twice, each time for 1 h, collect the filtrate, centrifuge at 800 rpm for 10 min, take the supernatant, concentrate, and low-temperature dry to obtain extract III;

[0064] (4) Grind the ginkgo, white lentil and licorice raw materials, pass through a 70-mesh sieve to obtain a mixed powder D, add the mixed powder D into ethyl acetate at a ratio of mixed powder A: ethyl acetate (m:v=1:g11mL), stir evenly, reflux extract 3 times, each time for 7 hours, combine the extracts, centrifuge at 1200 rpm for 1 minute, concentrate the supernatant, and dry at low temperature to obtain extract IV;

[0065] (5) After extracts I to IV are mixed evenly, a mixture can be obtained;

[0066] Comparative Example 2

[0067] Compared with Example 2, steps (2) to (4) are directly replaced by crushing and sieving the raw materials, mixing them in a ratio of raw materials: distilled water = 1 g: 15 mL, soaking them for 30 minutes, boiling them over high heat for 30 minutes, filtering them, and drying them to obtain the total extract.

[0068] Comparative Example 3

[0069] Compared with Example 2, loquat leaves, andrographis paniculata, Euryale ferox, tangerine peel and ebony are removed, and the other components remain unchanged.

[0070] Comparative Example 4

[0071] Compared with Example 2, the content of each component is different, specifically including: 40 parts of loquat leaves, 60 parts of Andrographis paniculata, 53 parts of Euryale ferox, 48 parts of orange peel, 50 parts of orange peel, 38 parts of Momordica grosvenori, 40 parts of Platycodon grandiflorum, 36 parts of Poria, 35 parts of Prunus mume, 35 parts of Astragalus, 32 parts of Dioscorea opposita, 30 parts of Polygonatum odoratum, 13 parts of Lilium, 10 parts of Houttuynia cordata, 10 parts of Alpinia oxyphylla, 24 parts of Fritillaria cirrhosa, 26 parts of Ginkgo, 23 parts of Coix seeds, 8 parts of Codonopsis pilosula, 5 parts of Trichosanthes, 19 parts of Fritillaria, 5 parts of Radix Glycyrrhizae Preparata, 13 parts of Aucklandia lappa, 3 parts of Atractylodes macrocephala, 1 part of Ophiopogon japonicus, 12 parts of Gynostemma pentaphyllum, 10 parts of Cloves, 1 part of Chelidonium herb, 7 parts of Gypsum, 8 parts of Adhesive, and 5 parts of Beeswax.

[0072] Comparison of the therapeutic effects of different herbal fumigation moxibustion

[0073] A total of 160 patients aged 18-50 years were selected, with an average age of 38 years. All patients were diagnosed with lung and spleen deficiency cough. Clinical symptoms included cough, pale red tongue with thin white coating, weak pulse, with or without sputum, wheezing, shortness of breath, night sweats, chills, shortness of breath and fatigue, pale complexion, poor appetite, abdominal distension, loose stools, etc.; patients with drug allergies, pregnant or lactating women, and patients with severe cardiovascular and cerebrovascular diseases, liver and kidney dysfunction, and mental illness were excluded.

[0074] Treatment method: During the operation, the patient is asked to lie in supine position. After the acupoints such as Feishu, Tanzhong, Dazhui, Dingchuan, Gaomang, etc. are routinely disinfected with alcohol, a Chinese medicine fumigation medicine box is used and placed on the corresponding acupoints of the patient. Each time lasts for 25 minutes, twice a day, and the efficacy is evaluated after 15 consecutive days of treatment; Control group: patients use montelukast sodium tablets, 10 mg per tablet, once a day, 1 tablet each time, and the efficacy is observed after oral administration for 15 days. The measurement results are shown in Tables 2-4.

[0075] The evaluation criteria are as follows:

[0076] (1) Treatment effect: marked effect, cough symptoms completely disappear; effective: cough symptoms basically disappear, no aggravation after drug withdrawal; ineffective, that is, the patient's cough symptoms do not improve significantly, or even worsen. The marked effect rate is calculated by dividing the marked effect by the total number of cases;

[0077] (2) Improvement of cough symptoms: including cough relief time and cough resolution time;

[0078] (3) Improvement of TCM symptom scores: Patients were scored using a modified symptom score table developed in the Guiding Principles for Clinical Research of New Chinese Medicines, with the main scoring criteria being cough, sputum production, and shortness of breath. The specific scoring criteria are shown in Table 1.

[0079] Table 1 Evaluation criteria

[0080]

[0081] Table 2 The therapeutic effects of different herbal fumigation moxibustion

[0082]

[0083] As shown in Table 2, compared with the control group, the patient was treated with herbal fumigation and moxibustion prepared by Examples 1-4 of the present invention, and the apparent efficiency was as high as 80%; compared with Comparative Example 1, although it has a certain therapeutic effect, it is significantly lower than the present invention; compared with Comparative Examples 2-3, after the preparation method and raw materials are deleted, the therapeutic effect achieved is not as good as the effect of herbal fumigation and moxibustion in the present invention, and Comparative Example 4 is different from Example 2 in terms of the content of each component, but not within the scope of the present invention to provide a suitable component, so, its apparent efficiency is relatively low, but higher than Comparative Examples 2-3, that is because each component is complete and still has a certain therapeutic effect. It can be seen that in the herbal fumigation and moxibustion of the present invention, each component can work together to achieve a better therapeutic effect through reasonable matching.

[0084] Table 3 Improvement of cough symptoms in patients after different herbal fumigation

[0085]

[0086] As shown in Table 3, compared with the control group, the herbal fumigation and moxibustion prepared by Examples 1-4 of the present invention can significantly shorten the cough relief time and disappearance time of the patients, and the effect of Example 2 is the best, indicating that the herbal fumigation and moxibustion of the present invention can significantly improve the cough symptoms; while the comparative examples 1-4 can also improve the cough symptoms to a certain extent, but the improvement degree is significantly lower than the effect of the herbal fumigation and moxibustion of Example 2 of the present invention. It can be shown that the herbal fumigation and moxibustion of the present invention has the effect of improving cough symptoms.

[0087] Table 4 Improvement of TCM symptom scores of patients after different herbal fumigation and moxibustion

[0088]

[0089] It can be seen from Table 4 that, compared with the control group, the patients can significantly improve symptoms such as cough, sputum and shortness of breath after the herbal fumigation treatment prepared by Examples 1-4 of the present invention, and the effect of Example 2 is the best; compared with Comparative Example 1, although it can improve the symptoms, the improvement effect is lower than that of the present invention; compared with Comparative Examples 2-3, after the preparation method and raw materials are deleted, the improvement effect is not as good as the effect of the herbal fumigation in the present invention. Compared with Example 2, the content of each component in Comparative Example 4 is different, but not within the appropriate component range given by the present invention, so its improvement effect is not good, but it is higher than that of Comparative Examples 2-3, because all components are complete and still have a certain therapeutic effect.

[0090] In summary, the herbal fumigation and moxibustion of the present invention can effectively regulate the symptoms of cough, sputum, shortness of breath and the like caused by people with lung and spleen deficiency constitution. It has the effect of strengthening the spleen and clearing the lungs, has a good therapeutic effect on cough, and can also play the role of removing phlegm and replenishing qi.

[0091] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0092] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A herbal fumigation medicine for strengthening the spleen and clearing the lungs, characterized in that: The invention is composed of the following raw materials by weight: 45-55 parts of loquat leaves, 40-55 parts of andrographis paniculata, 40-50 parts of Euryale ferox, 35-45 parts of orange peel, 30-45 parts of orange peel, 28-34 parts of Momordica grosvenori, 25-35 parts of Platycodon grandiflorum, 23-31 parts of Poria cocos, 22-30 parts of Prunus mume, 20-30 parts of Astragalus, 20-27 parts of Chinese yam, 19-26 parts of Polygonatum odoratum, 15-26 parts of Lilium, 15 -26 parts of Houttuynia cordata, 15-24 parts of Alpinia oxyphylla, 14-20 parts of Fritillaria cirrhosa, 13-19 parts of Ginkgo biloba, 13-19 parts of Coix seeds, 11-16 parts of Codonopsis pilosula, 10-16 parts of Trichosanthes, 8-14 parts of Fritillaria, 7-11 parts of Radix Glycyrrhizae Preparata, 5-11 parts of Aucklandia lappa, 5-11 parts of Atractylodes macrocephala, 3-10 parts of Ophiopogon japonicus, 3-10 parts of Gynostemma pentaphyllum, 3-8 parts of Clove, 3-8 parts of Greater Chelidonis, and 1-5 parts of Gypsum; The steps of the preparation method of the herbal fumigation moxibustion are as follows: The following steps are involved: (1) Weigh the raw materials according to the above weight proportions and set aside; (2) Grind loquat leaves, tangerine peel, monk fruit, platycodon, houttuynia cordata, trichosanthes, and licorice root, and pass through a 60-80 mesh sieve to obtain a mixed powder A. Add the mixed powder A to a methanol aqueous solution at a ratio of mixed powder A: methanol (m:v) = 1 g: 6-8 mL, stir evenly, perform water bath ultrasonic extraction, filter, centrifuge, and dry under reduced pressure to obtain extract I; (3) Crush the raw materials of tangerine peel, black plum, Chinese yam, polygonatum odoratum, lily, coix seed and costusroot, and pass through a 60-80 mesh sieve to obtain a mixed powder B, add the mixed powder B into distilled water according to the ratio of mixed powder B: distilled water m:v=1g:8-10mL, stir evenly, add pectinase after preheating for ultrasonic enzymolysis, place in boiling water to inactivate the enzyme after completion, filter, centrifuge, and dry under reduced pressure to obtain extract II; (4) Grind the raw materials of Andrographis paniculata, Codonopsis pilosula, Poria cocos, Astragalus membranaceus, Alpinia oxyphylla, Clove, and Greater celandine, and pass through a 60-80 mesh sieve to obtain a mixed powder C. Add the mixed powder A to an ethanol aqueous solution at a ratio of mixed powder A: ethanol m:v = 1 g: 2-4 mL, stir evenly, reflux extraction, collect the filtrate, centrifuge, and dry under reduced pressure to obtain extract III; (5) Grind the raw materials of Euryale ferox, Fritillaria cirrhosa, Ginkgo biloba, Fritillaria thunbergii, Atractylodes macrocephala, Ophiopogon japonicus, Gynostemma pentaphyllum, and gypsum, and pass through a 60-80 mesh sieve to obtain a mixed powder D, add the mixed powder D into ethyl acetate in a ratio of mixed powder A: ethyl acetate m:v = 1 g: 10-12 mL, stir evenly, reflux extraction, combine the extracts and centrifuge, and dry under reduced pressure to obtain extract IV; (6) After the extracts I-IV are mixed evenly, a mixed extract is obtained, and then yeast liquid and water are added for fermentation. After drying and sterilization, a mixture can be obtained.

2. The drug according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 52 parts of loquat leaves, 55 parts of andrographis paniculata, 46 parts of euryale ferox, 38 parts of tangerine peel, 30 parts of momordica grosvenori, 32 parts of platycodon grandiflorum, 31 parts of tuckahoe, 27 parts of ebony, 23 parts of astragalus, 20 parts of yam, 21 parts of polygonatum odoratum, 23 parts of lily, 26 parts of houttuynia cordata, 21 parts of alkyl oxyphylla, 16 parts of fritillaria cirrhosa, 13 parts of ginkgo, 15 parts of coix seeds, 15 parts of codonopsis pilosula, 16 parts of trichosanthes, 12 parts of fritillaria, 8 parts of roasted licorice, 5 parts of costusroot, 7 parts of atractylodes macrocephala, 9 parts of ophiopogon japonicus, 10 parts of gynostemma pentaphyllum, 7 parts of clove, 5 parts of celandine and 1 part of gypsum.

3. The drug according to claim 1, characterized in that In step (2), the volume concentration of the methanol aqueous solution is 68%-72%; the water bath temperature is 55-60°C, the ultrasonic power is 800-1000W, and the extraction time is 0.5-1h; and the centrifugation is 500-1000rpm for 3-10min.

4. The drug according to claim 1, characterized in that In step (3), the preheating temperature is 40-50°C; the amount of pectinase added is 1-2% of the mass of the mixed powder B; the ultrasonic power is 600-800W, the enzymatic hydrolysis time is 50-60min; the enzyme inactivation time is 5-15min; and the centrifugation is 500-800rpm for 5-10min.

5. The drug according to claim 1, characterized in that In step (4), the volume concentration of the ethanol aqueous solution is 90%-95%; the number of extractions is 2-4 times, and the extraction time is 1-2 hours per time; and the centrifugation is performed at 600-800 rpm for 10-15 minutes.

6. The medicine according to claim 1, characterized in that In step (5), the extraction times are 3-5 times, and the extraction time is 6-8 hours / time; the centrifugation is performed at 1000-1200 rpm for 1-5 minutes.

7. The drug according to claim 1, characterized in that In step (6), the yeast culture liquid has a bacterial content of 2×108-5×108 cfu / mL; the weight volume ratio of the mixed extract, yeast culture liquid and water is (3-8) g:(2-5) mL:(50-100) mL; and the fermentation is carried out at 25-35° C. for 1-2 days.

8. The medicine according to claim 1, characterized in that In steps (2) to (6), the reduced pressure drying is performed at 30-50° C. for 48-60 hours until the water content is 3-5%.

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