Composition for improving hemorrhoid symptoms, wet wipes liquid, wet wipes and preparation method thereof and sanitary products

Abstract

The present application provides a composition for improving hemorrhoid symptoms, wet wipes, wet wipes and their preparation method and sanitary products, and relates to the technical field of sanitary products. By mass percentage, the composition for improving hemorrhoid symptoms includes 0.1~2.2% of myrrh extract, 0.1~2.2% of purslane extract, 0.05~1.2% of tooth valve Corydalis root extract, 0.04~1.2% of Bletilla striata extract, 0.04~1.2% of Galla chinensis extract and the remainder of water. The composition of the present application has multiple effects such as analgesia, hemostasis, anti-inflammatory, and detumescence, which can effectively relieve hemorrhoidal symptoms, and the composition of the present application is mild and non-irritating to the anus, and can effectively reduce the irritation of the preservative liquid in the wet wipes. The composition of the present application is used to prepare toilet wipes, which can significantly improve the cleaning effect and comfort of the perianal area of ​​hemorrhoid patients.

Description

Technical Field

[0001] The present application relates to the technical field of sanitary products, and in particular to a composition for improving hemorrhoidal symptoms, wet wipes liquid, wet wipes and a preparation method thereof, and sanitary products. Background Art

[0002] The main symptoms of hemorrhoids include pain, bleeding, itching, and mole prolapse, which cause great discomfort and distress to patients. Existing hemorrhoid treatment drugs are inconvenient to use, and it is difficult to clean and treat anytime and anywhere. They may aggravate bacterial infections and cause symptoms to worsen, thus affecting the effect of drug treatment. Toilet wipes products currently on the market have the defect of being highly irritating. Although toilet wipes have a certain perianal cleaning effect, for hemorrhoid patients, especially those with external hemorrhoids, highly irritating wipes are prone to cause adverse stimulation to the flesh masses formed in the perianal area.

[0003] Specifically, in order to maintain the moistness of wet wipes and extend their shelf life, manufacturers usually add preservatives including quaternary ammonium salts or chlorhexidine to the wet wipes. However, preservatives are irritating to the skin. This irritation may vary from individual to individual. Long-term use or excessive use of wet wipes containing preservatives may cause adverse stimulation to the skin and mucous membranes, leading to allergic reactions and damage to the skin barrier function. Long-term or excessive use of wet wipes containing preservatives by patients with hemorrhoids will cause high irritation to the perianal area, poor relief of hemorrhoidal symptoms, and may even worsen the condition of hemorrhoids.

[0004] Therefore, it is necessary to improve the existing wet wipes to meet the needs of users to relieve hemorrhoid symptoms. Summary of the invention

[0005] The purpose of the present application is to provide a composition for improving hemorrhoid symptoms, a wet wipes liquid, a wet wipes and a preparation method thereof and a sanitary product to solve the above-mentioned problems.

[0006] To achieve the above objectives, this application adopts the following technical solutions:

[0007] A composition for improving hemorrhoid symptoms, comprising, by mass percentage, 0.1-2.2% of myrrh extract, 0.1-2.2% of purslane extract, 0.05-1.2% of Corydalis dentata root extract, 0.04-1.2% of Bletilla striata extract, 0.04-1.2% of Galla chinensis extract and the remainder of water.

[0008] According to an embodiment of the present application, the composition for improving hemorrhoid symptoms includes, by mass percentage, 0.2-2% of myrrh extract, 0.2-2% of purslane extract, 0.08-1% of Corydalis dentata root extract, 0.06-1% of Bletilla striata extract, 0.06-1% of Galla chinensis extract and the remainder of water.

[0009] The present application also provides a wet wipe liquid, which comprises an antiseptic liquid and the composition for improving hemorrhoid symptoms as described above.

[0010] According to an embodiment of the present application, the mass ratio of the composition for improving hemorrhoid symptoms to the preservative liquid is (1.8~2.2):1.

[0011] According to an embodiment of the present application, the preservative liquid includes a quaternary ammonium salt preservative liquid or a chlorhexidine preservative liquid.

[0012] According to an embodiment of the present application, based on the total mass of the quaternary ammonium salt preservative solution, the quaternary ammonium salt preservative solution includes 0.05-0.15% of benzalkonium chloride, 0.45-0.55% of cetylpyridinium chloride, 0.04-0.06% of didecyl dimethyl ammonium chloride, 0.04-0.06% of C12-14 alkyl dimethyl ethyl benzyl ammonium chloride and the remainder of water.

[0013] According to an embodiment of the present application, based on the total mass of the chlorhexidine preservative solution, the chlorhexidine preservative solution includes 0.25-0.35% of chlorhexidine gluconate, 0.45-0.55% of phenoxyethanol, 0.04-0.06% of ethylhexylglycerol, 0.15-0.25% of chlorphenesin and the balance of water.

[0014] The present application also provides a wet wipe, which includes a non-woven fabric and a wet wipe liquid loaded on the non-woven fabric, and the wet wipe liquid is the wet wipe liquid described above.

[0015] The present application also provides a method for preparing the wet wipes as described above, comprising: spraying wet wipes liquid on a non-woven fabric to obtain wet wipes.

[0016] The present application also provides a sanitary product, which includes the wet wipes described above.

[0017] Compared with the prior art, the beneficial effects of this application include:

[0018] The composition of the present application has both the effect of relieving hemorrhoid symptoms and low irritation, and has the advantages of being mild and low irritation. Specifically, the specific contents of myrrh extract, purslane extract, Corydalis root extract, Bletilla striata extract, and Galla chinensis extract cooperate with each other in function, so that the composition of the present application has multiple effects such as analgesia, hemostasis, anti-inflammatory, and detumescence, and can effectively relieve hemorrhoidal symptoms. In addition, the composition of the present application is mild and non-irritating to the anus, and can effectively reduce the irritation of the preservative liquid in the wet wipes. The composition of the present application is used to prepare toilet wet wipes, which can significantly improve the cleaning effect and comfort of the perianal area of ​​hemorrhoid patients.

[0019] The wet wipes liquid, wet wipes, wet wipes prepared by the method of the present application, and sanitary products all have the advantages of being mild and low in irritation, can improve hemorrhoidal symptoms, and can also enhance the user experience of hemorrhoidal patients. DETAILED DESCRIPTION

[0020] As used herein:

[0021] "Prepared from" is synonymous with "comprising." As used herein, the terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

[0022] The conjunction "consisting of excludes any unspecified element, step, or component. If used in a claim, this phrase renders the claim closed-ended so that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim rather than immediately following the subject matter, it limits only the elements described in that clause; other elements are not excluded from the claim as a whole.

[0023] When an amount, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper preferred values ​​and lower preferred values, this should be understood as specifically disclosing all ranges formed by any pairing of any range upper limit or preferred value with any range lower limit or preferred value, regardless of whether the range is disclosed separately. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted as including ranges "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5", etc. When a numerical range is described in this article, unless otherwise stated, the range is intended to include its end values ​​and all integers and fractions within the range.

[0024] In these examples, parts and percentages are by mass unless otherwise indicated.

[0025] "Mass parts" refers to the basic unit of measurement for expressing the mass ratio of multiple components. 1 part can represent any unit mass, such as 1g or 2.689g. If we say that the mass parts of component A are a parts and the mass parts of component B are b parts, it means the ratio of the mass of component A to the mass of component B is a:b. Alternatively, it means that the mass of component A is aK and the mass of component B is bK (K is an arbitrary number, indicating a multiple factor). It should not be misunderstood that, unlike the mass parts, the sum of the mass parts of all components is not limited to 100 parts.

[0026] "And / or" is used to indicate that one or both of the stated situations may occur, for example, A and / or B includes (A and B) and (A or B).

[0027] A composition for improving hemorrhoid symptoms, comprising, by mass percentage, 0.1-2.2% of myrrh extract, 0.1-2.2% of purslane extract, 0.05-1.2% of Corydalis dentata root extract, 0.04-1.2% of Bletilla striata extract, 0.04-1.2% of Galla chinensis extract and the remainder of water.

[0028] Currently, there is no specific drug for hemorrhoids. When dealing with relatively mild symptoms of hemorrhoids, the clinic generally tends to adopt conservative treatment as the first choice. Among them, Chinese herbal medicine therapy is favored for its unique advantages. Whether it is applied externally or taken internally, the core treatment goals of Chinese herbal medicine focus on reducing inflammation and swelling, relieving pain and soothing, stopping bleeding and promoting tissue astringency, aiming to effectively relieve the discomfort and symptoms caused by hemorrhoids.

[0029] The myrrh extract of the present application has the effect of anti-inflammatory and pain relief, which helps to alleviate the pain and inflammation of hemorrhoid patients. The purslane extract has the effect of clearing away heat and detoxicating, dispersing blood and reducing swelling, which helps to alleviate the heat and toxicity of hemorrhoid patients. The root extract of Corydalis Root has the effect of promoting qi and relieving pain, promoting blood circulation and removing blood stasis, which helps to alleviate the pain of hemorrhoid patients. The Bletilla striata extract has the effect of astringing and stopping bleeding, reducing swelling and promoting tissue regeneration and preventing wound infection, which helps to alleviate the bleeding and hemorrhoid swelling symptoms of hemorrhoid patients. The gallnut extract has the effect of stopping blood and clearing fire, collecting moisture and consolidating sores, which helps to alleviate the bleeding and sore symptoms of hemorrhoid patients, and also has good antibacterial ability, which can effectively inhibit and kill microorganisms, and helps to sterilize and clean. The above-mentioned Chinese herbal medicine components cooperate with each other, and the present application composition can have multiple effects such as analgesia, hemostasis, promoting blood circulation and removing blood stasis, anti-inflammatory, cooling blood and reducing fire, and reducing swelling, which can effectively alleviate hemorrhoid symptoms. Moreover, the composition of the present application has the advantages of being mild and low in irritation, can effectively reduce the irritation of the preservative liquid in the wet wipes, and is mild and non-irritating to the anus. The composition of the present application is used to prepare toilet wet wipes, which can significantly improve the cleaning effect and comfort of the perianal area of ​​hemorrhoid patients.

[0030] When the contents of myrrh extract, purslane extract, Corydalis serrulata root extract, Bletilla striata extract, and Galla chinensis extract are within the content range defined in the present application, the composition can have both a good effect of improving hemorrhoidal symptoms and low irritation. If the contents of myrrh extract and / or purslane extract and / or Corydalis serrulata root extract and / or Bletilla striata extract and / or Galla chinensis extract are too little, the effect of improving hemorrhoidal symptoms and reducing irritation will be poor. If the contents of myrrh extract and / or purslane extract and / or Corydalis serrulata root extract and / or Bletilla striata extract and / or Galla chinensis extract are too much, the effect of significantly reducing irritation will not be achieved, and the production cost will also be increased.

[0031] Furthermore, in the composition for improving hemorrhoid symptoms, the content of myrrh extract can be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2% or any value between 0.1 and 2.2%.

[0032] In the composition for improving hemorrhoid symptoms, the content of Portulaca oleracea extract can be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2% or any value between 0.1% and 2.2%.

[0033] In the composition for improving hemorrhoid symptoms, the content of the Corydalis dentata root extract can be 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2% or any value between 0.05 and 1.2%.

[0034] In the composition for improving hemorrhoid symptoms, the content of Bletilla striata extract can be 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2% or any value between 0.04 and 1.2%.

[0035] In the composition for improving hemorrhoid symptoms, the content of the gallnut extract can be 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2% or any value between 0.04 and 1.2%.

[0036] According to an embodiment of the present application, the composition for improving hemorrhoid symptoms includes, by mass percentage, 0.2-2% of myrrh extract, 0.2-2% of purslane extract, 0.08-1% of Corydalis dentata root extract, 0.06-1% of Bletilla striata extract, 0.06-1% of Galla chinensis extract and the remainder of water.

[0037] According to the embodiments of the present application, the composition for improving hemorrhoid symptoms satisfies any one of the following conditions:

[0038] The composition for improving hemorrhoid symptoms comprises 0.2% of myrrh extract, 0.2% of purslane extract, 0.2% of Corydalis root extract, 0.2% of Bletilla striata extract, 0.2% of Galla chinensis extract and the balance of water;

[0039] The composition for improving hemorrhoid symptoms comprises 0.4% of myrrh extract, 0.4% of purslane extract, 0.08% of Corydalis root extract, 0.06% of Bletilla striata extract, 0.06% of Galla chinensis extract and the balance of water;

[0040] The composition for improving hemorrhoid symptoms comprises 1% of myrrh extract, 1% of purslane extract, 1% of Corydalis dentata root extract, 1% of Bletilla striata extract, 1% of Galla chinensis extract and the balance of water;

[0041] The composition for improving hemorrhoid symptoms comprises 2% of myrrh extract, 2% of purslane extract, 0.4% of Corydalis dentata root extract, 0.3% of Bletilla striata extract, 0.3% of Galla chinensis extract and the balance of water.

[0042] The present application also provides a wet wipe liquid, which comprises an antiseptic liquid and the composition for improving hemorrhoidal symptoms as described above.

[0043] According to an embodiment of the present application, the mass ratio of the composition for improving hemorrhoidal symptoms to the preservative liquid is (1.8-2.2): 1. Thus, the wet wipes liquid can have excellent preservative performance, low irritation, excellent bactericidal effect and excellent effect of improving hemorrhoidal symptoms. If the mass ratio of the composition for improving hemorrhoidal symptoms to the preservative liquid is lower, the content of the composition for improving hemorrhoidal symptoms is relatively low and the content of the preservative liquid is relatively high, the effect of reducing the irritation of the wet wipes liquid and improving the hemorrhoidal symptoms will not be obvious.

[0044] Specifically, the mass ratio of the composition for improving hemorrhoid symptoms to the preservative solution can be 1.8:1, 1.9:1, 2.0:1, 2.1:1, 2.2:1 or any value between (1.8-2.2):1.

[0045] According to an embodiment of the present application, the preservative liquid includes a quaternary ammonium salt preservative liquid or a chlorhexidine preservative liquid.

[0046] According to an embodiment of the present application, based on the total mass of the quaternary ammonium salt preservative solution, the quaternary ammonium salt preservative solution includes 0.05-0.15% of benzalkonium chloride, 0.45-0.55% of cetylpyridinium chloride, 0.04-0.06% of didecyl dimethyl ammonium chloride, 0.04-0.06% of C12-14 alkyl dimethyl ethyl benzyl ammonium chloride and the remainder of water.

[0047] According to the embodiments of the present application, based on the total mass of the quaternary ammonium salt preservative solution, the content of benzalkonium chloride in the quaternary ammonium salt preservative solution can be 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.10%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15% or any value between 0.05 and 0.15%.

[0048] According to the embodiments of the present application, based on the total mass of the quaternary ammonium salt preservative solution, the content of cetylpyridinium chloride in the quaternary ammonium salt preservative solution can be 0.45%, 0.46%, 0.47%, 0.48%, 0.49%, 0.50%, 0.51%, 0.52%, 0.53%, 0.54%, 0.55% or any value between 0.45 and 0.55%.

[0049] According to the embodiments of the present application, based on the total mass of the quaternary ammonium salt preservative solution, the content of didecyl dimethyl ammonium chloride in the quaternary ammonium salt preservative solution can be 0.04%, 0.05%, 0.06% or any value between 0.04 and 0.06%.

[0050] According to the embodiments of the present application, based on the total mass of the quaternary ammonium salt preservative solution, the content of C12-14 alkyl dimethyl ethyl benzyl ammonium chloride in the quaternary ammonium salt preservative solution can be 0.04%, 0.05%, 0.06% or any value between 0.04 and 0.06%.

[0051] According to an embodiment of the present application, based on the total mass of the chlorhexidine preservative solution, the chlorhexidine preservative solution includes 0.25-0.35% of chlorhexidine gluconate, 0.45-0.55% of phenoxyethanol, 0.04-0.06% of ethylhexylglycerol, 0.15-0.25% of chlorphenesin and the balance of water.

[0052] According to an embodiment of the present application, based on the total mass of the chlorhexidine preservative solution, the content of chlorhexidine gluconate in the chlorhexidine preservative solution can be 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, 0.30%, 0.31%, 0.32%, 0.33%, 0.34%, 0.35% or any value between 0.25 and 0.35%.

[0053] According to an embodiment of the present application, based on the total mass of the chlorhexidine preservative solution, the content of phenoxyethanol in the chlorhexidine preservative solution can be 0.45%, 0.46%, 0.47%, 0.48%, 0.49%, 0.50%, 0.51%, 0.52%, 0.53%, 0.54%, 0.55% or any value between 0.45 and 0.55%.

[0054] According to an embodiment of the present application, based on the total mass of the chlorhexidine preservative solution, the content of ethylhexylglycerin in the chlorhexidine preservative solution can be 0.04%, 0.05%, 0.06% or any value between 0.04 and 0.06%.

[0055] According to an embodiment of the present application, based on the total mass of the chlorhexidine preservative solution, the content of chlorphenesin in the chlorhexidine preservative solution can be 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.20%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25% or any value between 0.15 and 0.25%.

[0056] The present application also provides a wet wipe, which includes a non-woven fabric and a wet wipe liquid loaded on the non-woven fabric, and the wet wipe liquid is the wet wipe liquid described above.

[0057] The present application also provides a method for preparing the wet wipes as described above, comprising: spraying wet wipes liquid on a non-woven fabric to obtain wet wipes.

[0058] The present application also provides a sanitary product, which includes the wet wipes described above.

[0059] Furthermore, the sanitary product also includes a packaging box or a packaging bag, and wet wipes located in the packaging box or the packaging bag.

[0060] The embodiments of the present application will be described in detail below in conjunction with specific examples, but it will be appreciated by those skilled in the art that the following examples are only used to illustrate the present application and should not be considered as limiting the scope of the present application. If specific conditions are not specified in the examples, they are carried out according to normal conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0061] The reagent information used in the following examples and comparative examples is as follows:

[0062] Chinese herbal medicine extracts include myrrh extract, purslane extract, Corydalis serrulata root extract, Bletilla striata extract, and Gallnut extract.

[0063] The Chinese herbal medicine extracts (myrrh extract, purslane extract, spurred Corydalis root extract, Bletilla striata extract, and Galla chinensis extract) of the present application are prepared by the following method: take clean pieces of Chinese herbal medicine (myrrh, purslane, spurred Corydalis root, Bletilla striata, and Galla chinensis), add water at a material-liquid mass ratio of 1:8, soak for 0.5 hour, heat to boiling and then decoct for 2 hours, after decoction is completed, filter through a 120-mesh sieve; add 8 times the mass of water, heat to boiling and then decoct for 2 hours, after decoction is completed, filter through a 120-mesh sieve; add 6 times the mass of water, heat to boiling and then decoct for 1 hour, after decoction is completed, filter through a 120-mesh sieve to release the extract, transfer the filtrate to a liquid storage tank, and let it stand for 1-2 hours. The extract is passed through a 200-300 mesh filter cloth (high-speed centrifuge or filter press - commonly known as plate frame), and the filtered extract is placed in a concentrator. The steam pressure is controlled at 0.05Mpa, the vacuum degree is controlled at -0.05Mpa, and the concentration temperature is controlled at 70°C. It is concentrated to a fluid extract with a relative density (specific gravity) of 1.10g / ml (60°C) and placed in a clean barrel. The above qualified extract is dried by spray drying. The inlet air temperature is controlled at 150°C and the outlet air temperature is controlled at 70°C for spray drying. The spray-dried powder and the fine powder cleared from the drying tower are fully mixed in a mixer for 50 minutes. The fully mixed powder is then crushed into fine powder by passing through an 80-mesh sieve in a pulverizer. The extract is concentrated and dried to obtain Chinese herbal medicine extracts (myrrh extract, purslane extract, tooth-petal Corydalis root extract, Bletilla striata extract, and Galla chinensis extract).

[0064] Example 1

[0065] Example 1 provides a composition for improving hemorrhoid symptoms. The composition for improving hemorrhoid symptoms includes, by mass percentage, 0.2% of myrrh extract, 0.2% of purslane extract, 0.2% of Corydalis dentata root extract, 0.2% of Bletilla striata extract, 0.2% of Galla chinensis extract and the remainder of water.

[0066] The components are weighed according to the above content relationship, mixed and stirred evenly to obtain the composition for improving hemorrhoid symptoms in Example 1.

[0067] Example 2

[0068] Example 2 provides a composition for improving hemorrhoid symptoms. The composition for improving hemorrhoid symptoms includes, by mass percentage, 0.4% of myrrh extract, 0.4% of purslane extract, 0.08% of Corydalis dentata root extract, 0.06% of Bletilla striata extract, 0.06% of Galla chinensis extract and the remainder of water.

[0069] The method for preparing the composition for improving hemorrhoid symptoms in Example 2 is the same as that in Example 1, except that the content of each component is different.

[0070] Example 3

[0071] Example 3 provides a composition for improving hemorrhoid symptoms. The composition for improving hemorrhoid symptoms includes, by mass percentage, 1% of myrrh extract, 1% of purslane extract, 1% of Corydalis dentata root extract, 1% of Bletilla striata extract, 1% of Galla chinensis extract and the remainder of water.

[0072] The method for preparing the composition for improving hemorrhoid symptoms in Example 3 is the same as that in Example 1, except that the content of each component is different.

[0073] Example 4

[0074] Example 4 provides a composition for improving hemorrhoid symptoms. The composition for improving hemorrhoid symptoms includes, by mass percentage, 2% of myrrh extract, 2% of purslane extract, 0.4% of Corydalis dentata root extract, 0.3% of Bletilla striata extract, 0.3% of Galla chinensis extract and the remainder of water.

[0075] The method for preparing the composition for improving hemorrhoid symptoms in Example 4 is the same as that in Example 1, except that the content of each component is different.

[0076] Comparative Example 1

[0077] Comparative Example 1 provides a composition for improving hemorrhoid symptoms, and the composition in Comparative Example 1 does not contain myrrh extract.

[0078] By mass percentage, the composition for improving hemorrhoid symptoms of Comparative Example 1 includes 0.4% of Portulaca oleracea extract, 0.08% of Corydalis dentata root extract, 0.06% of Bletilla striata extract, 0.06% of Galla chinensis extract and the balance of water.

[0079] Comparative Example 1 The method for preparing the composition for improving hemorrhoid symptoms is the same as that of Example 1, except that the types and contents of the components are different.

[0080] Comparative Example 2

[0081] Comparative Example 2 provides a composition for improving hemorrhoid symptoms, and the composition in Comparative Example 2 does not contain Portulaca oleracea extract.

[0082] By mass percentage, the composition for improving hemorrhoid symptoms of Comparative Example 2 includes 0.4% of myrrh extract, 0.08% of Corydalis dentata root extract, 0.06% of Bletilla striata extract, 0.06% of Galla chinensis extract and the balance of water.

[0083] Comparative Example 2 The method for preparing the composition for improving hemorrhoid symptoms is the same as that of Example 1, except that the types and contents of the components are different.

[0084] Application Example 1

[0085] Application Example 1 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 1 and a quaternary ammonium salt preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the quaternary ammonium salt preservative liquid is 2:1.

[0086] Based on the total mass of the quaternary ammonium salt preservative solution, the quaternary ammonium salt preservative solution includes 0.1% benzalkonium chloride, 0.5% cetylpyridinium chloride, 0.05% didecyldimethylammonium chloride, 0.05% C12-14 alkyldimethylethylbenzylammonium chloride and the balance water.

[0087] The wet wipes liquid of Application Example 1 is sprayed on non-woven fabric to obtain wet wipes.

[0088] Application Example 2

[0089] Application Example 2 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 2 and a quaternary ammonium salt preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the quaternary ammonium salt preservative liquid is 2:1.

[0090] The formula of the quaternary ammonium salt preservative solution in Application Example 2 is the same as the formula of the quaternary ammonium salt preservative solution in Application Example 1.

[0091] The wet wipes liquid of Application Example 2 is sprayed on the non-woven fabric to obtain wet wipes.

[0092] Application Example 3

[0093] Application Example 3 provides a wet wipes liquid, which includes the composition for mildly improving hemorrhoidal symptoms of Example 3 and a quaternary ammonium salt preservative liquid, and the mass ratio of the composition for improving hemorrhoidal symptoms to the quaternary ammonium salt preservative liquid is 2:1.

[0094] The formula of the quaternary ammonium salt preservative solution in Application Example 3 is the same as the formula of the quaternary ammonium salt preservative solution in Application Example 1.

[0095] The wet wipes liquid of Application Example 3 is sprayed on the non-woven fabric to obtain wet wipes.

[0096] Application Example 4

[0097] Application Example 4 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 4 and a quaternary ammonium salt preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the quaternary ammonium salt preservative liquid is 2:1.

[0098] The formula of the quaternary ammonium salt preservative solution in Application Example 4 is the same as the formula of the quaternary ammonium salt preservative solution in Application Example 1.

[0099] The wet wipes liquid of Application Example 4 is sprayed on the non-woven fabric to obtain wet wipes.

[0100] Application Example 5

[0101] Application Example 5 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 1 and chlorhexidine preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the chlorhexidine preservative liquid is 2:1.

[0102] Based on the total mass of the chlorhexidine preservative solution, the chlorhexidine preservative solution includes 0.3% chlorhexidine gluconate, 0.5% phenoxyethanol, 0.05% ethylhexylglycerin, 0.2% chlorphenesin and the balance water.

[0103] The wet wipes liquid of Application Example 5 is sprayed on the non-woven fabric to obtain wet wipes.

[0104] Application Example 6

[0105] Application Example 6 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 2 and chlorhexidine preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the chlorhexidine preservative liquid is 2:1.

[0106] The formula of the chlorhexidine antiseptic solution in Application Example 6 is the same as the formula of the chlorhexidine antiseptic solution in Application Example 5.

[0107] The wet wipes liquid of Application Example 6 is sprayed on the non-woven fabric to obtain wet wipes.

[0108] Application Example 7

[0109] Application Example 7 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 3 and chlorhexidine preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the chlorhexidine preservative liquid is 2:1.

[0110] The formula of the chlorhexidine antiseptic solution in Application Example 7 is the same as the formula of the chlorhexidine antiseptic solution in Application Example 5.

[0111] The wet wipes liquid of Application Example 7 is sprayed on non-woven fabric to obtain wet wipes.

[0112] Application Example 8

[0113] Application Example 8 provides a wet wipes liquid, which includes the composition for improving hemorrhoid symptoms of Example 4 and chlorhexidine preservative liquid, and the mass ratio of the composition for improving hemorrhoid symptoms to the chlorhexidine preservative liquid is 2:1.

[0114] The formula of the chlorhexidine antiseptic solution in Application Example 8 is the same as the formula of the chlorhexidine antiseptic solution in Application Example 5.

[0115] The wet wipes liquid of Application Example 8 is sprayed on the non-woven fabric to obtain wet wipes.

[0116] I. Irritation Test of Compositions of Examples 1-4 and Comparative Examples 1-2

[0117] The irritation of the compositions of Examples 1-4 and Comparative Examples 1-2 was tested respectively. The specific test method was as follows: refer to the "Chicken Embryo Chorioallantoic Membrane Test for Cosmetic Eye Irritation / Corrosion" (SN / T2329-2009), and the test was conducted using the reaction time method. Take 9-day-old SPF-grade chicken embryos for egg inspection, remove the eggshell at the top of the air chamber, and expose the chorioallantoic membrane (CAM). Take 0.3 mL of the test substance and drip it directly on the surface of the CAM, observe and record the time when bleeding, vascular melting, and coagulation begin within 5 minutes. Each test substance was subjected to 6 parallel experiments. At the same time, a negative control (mass fraction 0.9% sodium chloride injection) and a positive control (0.1 mol / L sodium hydroxide solution) were set up. According to the formula: IS = (301-sec H) × 5 / 300 + (301-sec L) × 7 / 300 + (301-sec C) × 9 / 300. Calculate the irritation score. Where: sec H is the average time for bleeding to start on the CAM membrane, in seconds (s); sec L is the average time for vascular melting to start on the CAM membrane, in seconds (s); sec C is the average time for coagulation to start on the CAM membrane, in seconds (s). Irritation classification: IS < 1, no irritation; 1 ≤ IS < 5, mild irritation; 5 ≤ IS < 9, moderate irritation; IS ≥ 9, strong irritation.

[0118] The irritation test results of the compositions of Examples 1-4 and Comparative Examples 1-2 are shown in Table 1.

[0119] Table 1 Test results of irritation of the compositions of Examples 1-4 and Comparative Examples 1-2

[0120]

[0121] It can be seen from Table 1 that the irritation value of the chicken embryo model experiment with a 0.1% SDS aqueous solution is 14.66, and adding the composition of Examples 1-4 to the 0.1% SDS aqueous solution can reduce the irritation value and can reduce the irritation value to below 9.74, and can even reduce the irritation value to 6.86. This shows that the composition for improving hemorrhoidal symptoms of the present application has the effect of reducing irritation.

[0122] The irritation value after adding the composition of comparative example 1-2 is greater than the irritation value after adding the composition of embodiment 1-4, indicating that only by adding specific amounts of myrrh extract, purslane extract, Corydalis serrulata root extract, Bletilla striata extract, and Galla chinensis extract at the same time can the effect of significantly reducing irritation be achieved.

[0123] II. Application Example 1-8 Test on Irritation and Bactericidal Rate of Wet Wipes

[0124] Corresponding to Example 1-8, the irritation and bactericidal rate of the wet wipes were tested. The irritation test method was carried out using the previously described "Chicken Embryo Chorioallantoic Membrane Test for Cosmetic Eye Irritation / Corrosion" (SN / T2329-2009) method. Bactericidal rate test steps: refer to the "Hygiene Standard for Disposable Sanitary Products" (GB15979-2024), and the test was carried out using the suspension method. Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 6538), and Candida albicans (ATCC 10231) bacterial suspensions were diluted to 10 5 cfu / mL~10 6 cfu / mL as the test bacterial suspension; take 4.5mL PBS and sample as control tube and sample tube respectively; take 0.5mL of the above bacterial suspension and add it to each sample tube and control tube respectively, mix well, start timing, and act for 5min. Take 0.5mL of the above mixed solution and add it to the test tube containing 4.5mL neutralizer, mix well, neutralize for 10min and make 10-fold dilutions, take 2-3 dilutions, take 1mL respectively, put them in two plates, pour 15mL of nutrient agar medium (bacteria) or Sabouraud agar medium (yeast) cooled to 40-45℃, turn the plate to make it fully uniform, turn the plate over after the agar solidifies, and culture at 36℃±1℃ for 48h (bacteria) or 72h (yeast), and count the viable colonies. Repeat the test 3 times and take the average value.

[0125] The test results of irritation and bactericidal rate of wet wipes liquid in Application Examples 1-8 are shown in Table 2.

[0126] Table 2 Test results of irritation and sterilization rate of wet wipes liquid in application examples 1-8

[0127]

[0128] The quaternary ammonium salt preservative solution in Table 2 includes 0.1% benzalkonium chloride, 0.5% cetylpyridinium chloride, 0.05% didecyldimethylammonium chloride, 0.05% C12-14 alkyldimethylethylbenzyl ammonium chloride and the balance water. The chlorhexidine preservative solution in Table 2 includes 0.3% chlorhexidine gluconate, 0.5% phenoxyethanol, 0.05% ethylhexylglycerin, 0.2% chlorphenesin and the balance water.

[0129] As can be seen from Table 2, the irritation value of the quaternary ammonium salt preservative solution control group is 15.49. After adding the composition of Examples 1-4 to the quaternary ammonium salt preservative solution, the irritation value of the wet wipes solution of Application Examples 1-4 is significantly reduced, and the irritation value of the wet wipes solution of Application Examples 1-4 can be reduced to below 9.31, and can even be reduced to 7.42. This shows that the composition for improving hemorrhoid symptoms of the present application can reduce the irritation of the quaternary ammonium salt preservative solution.

[0130] As can be seen from Table 2, the irritation value of the chlorhexidine preservative solution control group is 10.16. After adding the composition of Examples 1-4 to the chlorhexidine preservative solution, the irritation value of the wet wipes solution of Application Examples 5-8 is significantly reduced, and the irritation value of the wet wipes solution of Application Examples 5-8 can be reduced to below 8.66, and can even be reduced to 5.87. This shows that the composition for improving hemorrhoid symptoms of the present application can reduce the irritation of the chlorhexidine preservative solution.

[0131] That is to say, after adding the composition of Examples 1-4 to the preservative liquid, the irritation value of the preservative liquid can be reduced, that is, the wet wipes liquid of the present application has the advantage of low irritation.

[0132] Moreover, after adding the composition of Examples 1-4 to the preservative liquid, the sterilization rate of the preservative liquid will not be affected. In other words, the composition of the present application can significantly reduce the irritation of the preservative liquid while not affecting the sterilization rate of the preservative liquid. That is, the wet wipes liquid of the present application has the advantages of low irritation and high sterilization rate at the same time.

[0133] III. Application Example 1-8 Testing of Wet Wipes for Improving Hemorrhoidal Symptoms

[0134] 80 hemorrhoid patients were recruited to participate in the test. The test period was 1 month, 40 of them were male and 40 were female. Ten patients used the wet wipes for relieving hemorrhoid symptoms of Application Examples 1-8, 5 of them were male and 5 of them were female.

[0135] Directions for use: During the test period, use this wipe to wipe the anus and surrounding skin every morning, evening and after defecation.

[0136] The effect evaluation criteria are as follows: 1. Strong improvement: hemorrhoidal symptoms are significantly alleviated, and there is no pain or itching in the anus and surrounding skin; 2: Moderate improvement: hemorrhoidal symptoms are alleviated, and the pain and itching symptoms in the anus and surrounding skin are weakened; 3: No improvement: There is no change in hemorrhoidal symptoms.

[0137] After 80 patients used the wet wipes for relieving hemorrhoidal symptoms for one month, the statistical results are shown in Table 3.

[0138] Table 3 Statistical results of hemorrhoid patients using wet wipes from application examples 1-8

[0139]

[0140] The improvement rate in Table 3 refers to the percentage of the sum of the number of patients with moderate improvement and strong improvement to the total number of patients participating in the test.

[0141] As shown in Table 3, the wet wipes of Application Examples 1-8 have the effect of improving hemorrhoidal symptoms, and more than 80% of the patients have alleviated or even cured their hemorrhoidal symptoms and anal discomfort after using the wet wipes of the application. All subjects believe that the use is comfortable and convenient, and no irritation or adverse reactions are observed.

[0142] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit it. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present application.

[0143] In addition, those skilled in the art will appreciate that, although some embodiments herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present application and form different embodiments. For example, in the above claims, any one of the claimed embodiments may be used in any combination. The information disclosed in this background technology section is intended only to deepen the understanding of the overall background technology of the present application and should not be regarded as an admission or in any form of implication that the information constitutes prior art known to those skilled in the art.

Claims

1. A wet wipes liquid, characterized in that: The wet wipes liquid includes an antiseptic liquid and a composition for improving hemorrhoidal symptoms, wherein the antiseptic liquid includes a quaternary ammonium salt antiseptic liquid or a chlorhexidine antiseptic liquid; The composition for improving hemorrhoid symptoms comprises 0.1-2.2% of myrrh extract, 0.1-2.2% of purslane extract, 0.05-1.2% of Corydalis root extract, 0.04-1.2% of Bletilla striata extract, 0.04-1.2% of Galla chinensis extract and the balance of water; The myrrh extract, the purslane extract, the spurt corydalis root extract, the bletilla striata extract, and the gallnut extract are prepared in the following manner: take myrrh, purslane, spurt corydalis root, bletilla striata, and gallnut pure decoction pieces respectively, add water at a material-liquid mass ratio of 1:8, soak for 0.5 hour, heat to boiling and then decoct for 2 hours, after decoction is completed, filter through a 120-mesh sieve; add 8 times the mass of water, heat to boiling and then decoct for 2 hours, after decoction is completed, filter through a 120-mesh sieve; add 6 times the mass of water, heat to boiling and then decoct for 1 hour, after decoction is completed, filter through a 120-mesh sieve to release the extract, transfer the filtrate to a liquid storage tank, and let it stand for 1-2 hours; pass the extract through a 200-300 mesh filter cloth, take the filtered extract in a concentrator, and control the steam pressure at 0.05Mpa, the vacuum degree is controlled at -0.05Mpa, the concentration temperature is controlled at 70°C, the sample with a concentration temperature of 70°C is sampled, the density of the sample is tested at a temperature of 60°C, and when the density of the sample is 1.10g / ml, the concentration is stopped to obtain a fluid extract, which is placed in a clean barrel; the qualified fluid extract is dried by spray drying, the inlet air temperature is controlled at 150°C, and the outlet air temperature is controlled at 70°C, and spray drying is performed; the spray-dried powder and the fine powder cleared out of the drying tower are fully mixed in a mixer, and the mixing time is 50 minutes; the fully mixed powder is then sieved through an 80-mesh sieve in a pulverizer to be crushed into fine powder; the extract is concentrated and then dried to obtain the myrrh extract, the purslane extract, the tooth-petal Corydalis root extract, the Bletilla striata extract, and the Galla chinensis extract.

2. The wet wipes liquid according to claim 1, characterized in that: The composition for improving hemorrhoid symptoms comprises, by mass percentage, 0.2-2% of myrrh extract, 0.2-2% of purslane extract, 0.08-1% of Corydalis dentata root extract, 0.06-1% of Bletilla striata extract, 0.06-1% of Galla chinensis extract and the remainder of water.

3. The wet wipes liquid according to claim 1, characterized in that: The mass ratio of the composition for improving hemorrhoid symptoms to the preservative liquid is (1.8-2.2):

1.

4. The wet wipes liquid according to claim 1, characterized in that: Based on the total mass of the quaternary ammonium salt preservative solution, the quaternary ammonium salt preservative solution includes 0.05-0.15% of benzalkonium chloride, 0.45-0.55% of cetylpyridinium chloride, 0.04-0.06% of didecyl dimethyl ammonium chloride, 0.04-0.06% of C12-14 alkyl dimethyl ethyl benzyl ammonium chloride and the balance of water.

5. The wet wipes liquid according to claim 1, characterized in that: Based on the total mass of the chlorhexidine preservative solution, the chlorhexidine preservative solution includes 0.25-0.35% of chlorhexidine gluconate, 0.45-0.55% of phenoxyethanol, 0.04-0.06% of ethylhexylglycerol, 0.15-0.25% of chlorphenesin and the balance of water.

6. A wet wipe, characterized in that: The wet wipes include a non-woven fabric and a wet wipes liquid loaded on the non-woven fabric, and the wet wipes liquid is the wet wipes liquid according to any one of claims 1 to 5.

7. A method for preparing the wet wipes as claimed in claim 6, characterized in that: include: The wet wipes liquid is sprayed on non-woven fabrics to obtain wet wipes.

8. A sanitary product, characterized in that: The sanitary product comprises the wet wipes according to claim 7.

Images