Multi-channel transcranial electrical stimulation device and system

Abstract

The present application discloses a multi-channel transcranial electrical stimulation device and system, the device includes: a control module, a digital-to-analog conversion module, a multi-channel current source module, a channel selection module, and an electrical stimulation module, wherein the control module is used to obtain target basic physiological condition data corresponding to the target object; generate a corresponding target stimulation scheme according to the target basic physiological condition data; determine the stimulation parameters corresponding to the target stimulation scheme to obtain at least one stimulation parameter; at least one stimulation parameter includes the number of channels; determine the control instruction corresponding to at least one stimulation parameter to obtain a target control instruction; control the multi-channel transcranial electrical stimulation device to work according to the target control instruction to achieve multi-channel transcranial electrical stimulation of the target object. The embodiment of the present application is adopted to improve the therapeutic effect of tES.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to a multi-channel transcranial electrical stimulation device and system. Background Art

[0002] Transcranial electric stimulation (tES) is a non-invasive, economical, and well-tolerated central nervous system regulation technology that aims to stimulate the cerebral cortex by applying specific patterns of microcurrent to affect neural activity in specific brain areas.

[0003] At present, most of the tES devices on the market are single-channel outputs, focusing only on current stimulation of a single brain area. Single-channel output limits the diversity and flexibility of stimulation and is unable to stimulate multiple brain areas at the same time. The single stimulation scheme leads to poor therapeutic effects of tES on patients. Therefore, how to improve the therapeutic effects of tES has become an urgent problem to be solved. Summary of the invention

[0004] The embodiments of the present application provide a multi-channel transcranial electrical stimulation device and system, which can perform multi-channel current output, provide patients with personalized stimulation plans, and perform tES stimulation on multiple brain regions of the patient, thereby improving the therapeutic effect of tES.

[0005] In a first aspect, an embodiment of the present application provides a multi-channel transcranial electrical stimulation device, the device comprising: a control module, a digital-to-analog conversion module, a multi-channel current source module, a channel selection module, and an electrical stimulation module, wherein:

[0006] The first end of the control module is connected to the first end of the digital-to-analog conversion module, the second end of the digital-to-analog conversion module is connected to the first end of the multi-channel current source module, the second end of the multi-channel current source module is connected to the first end of the channel selection module, the second end of the channel selection module is connected to the first end of the electrical stimulation module, and the second end of the electrical stimulation module is connected to the target object; the digital-to-analog conversion module includes a plurality of first channels; the multi-channel current source module includes a plurality of second channels, each second channel corresponds to a first channel; the channel selection module includes a plurality of third channels, each third channel corresponds to a second channel; the electrical stimulation module includes a plurality of electrode assemblies;

[0007] The control module is used to obtain target basic physiological condition data corresponding to the target object; generate a corresponding target stimulation scheme according to the target basic physiological condition data; determine the stimulation parameters corresponding to the target stimulation scheme to obtain at least one stimulation parameter; the at least one stimulation parameter includes the number of channels; determine the control instruction corresponding to the at least one stimulation parameter to obtain a target control instruction; control the multi-channel transcranial electrical stimulation device to work according to the target control instruction to achieve multi-channel transcranial electrical stimulation of the target object; the target control instruction includes a first control instruction and a second control instruction;

[0008] The digital-to-analog conversion module is configured to receive the first control instruction of the control module; control the plurality of first channels to generate at least one first output voltage according to the first control instruction, and output the at least one first output voltage to the multi-channel current source module;

[0009] The multi-channel current source module is used to generate at least one first output current according to the at least one first output voltage, and output the at least one first output current to the channel selection module; each first output current corresponds to a first output voltage;

[0010] The channel selection module is used to receive the second control instruction of the control module, and control at least one third channel of the plurality of third channels to be in an open state according to the second control instruction, and output the at least one first output current to the electrical stimulation module through the at least one third channel;

[0011] The electrical stimulation module is used to determine the electrode assembly corresponding to the at least one first output current to obtain at least one electrode assembly, each electrode assembly corresponding to a first output current; through the at least one electrode assembly, the target object is subjected to transcranial electrical stimulation with a corresponding first output current among the at least one first output current to obtain corresponding transcranial electrical stimulation data.

[0012] In a second aspect, an embodiment of the present application provides a multi-channel transcranial electrical stimulation system, the system comprising a multi-channel transcranial electrical stimulation device as described in any one of the first aspects.

[0013] It can be seen that by implementing the multi-channel transcranial electrical stimulation device provided by the embodiment of the present invention, the control module obtains the target basic physiological condition data corresponding to the target object; generates a corresponding target stimulation scheme according to the target basic physiological condition data; determines the stimulation parameters corresponding to the target stimulation scheme to obtain at least one stimulation parameter; at least one stimulation parameter includes the number of channels; determines the control instruction corresponding to at least one stimulation parameter to obtain the target control instruction; controls the multi-channel transcranial electrical stimulation device to work according to the target control instruction to achieve multi-channel transcranial electrical stimulation of the target object. In this way, by obtaining the specific physiological condition data of the target object to generate a stimulation scheme, and selecting an appropriate number of channels according to the specific situation of the target object, it is possible to ensure that the stimulation scheme is highly personalized. Then, appropriate currents are output through these channels to perform tES stimulation on multiple brain regions of the target object to meet the specific needs of the target object, thereby improving the therapeutic effect of tES. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the background technology, the drawings required for use in the embodiments of the present application or the background technology will be described below.

[0015] Figure 1 It is a structural block diagram of a multi-channel transcranial electrical stimulation device provided in an embodiment of the present application;

[0016] Figure 2 is a structural block diagram of an impedance detection module provided in an embodiment of the present application;

[0017] Figure 3 This is a workflow diagram of a digital-to-analog conversion module provided in an embodiment of the present application;

[0018] Figure 4 It is a structural block diagram of a first constant current source circuit provided in an embodiment of the present application. DETAILED DESCRIPTION

[0019] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0020] The terms "first", "second", etc. in the specification and claims of this application and the above-mentioned drawings are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0021] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0022] The following is an explanation of some professional terms involved in this application:

[0023] tES: The Chinese name is transcranial electrical stimulation. It is a non-invasive neuromodulation technology that increases or decreases the excitability of neurons by applying weak electric current to the cerebral cortex through scalp electrodes, thereby achieving the purpose of regulation.

[0024] Stimulation parameters: In this application, stimulation parameters refer to various variables used to describe and control the tES process. Different stimulation parameters will have different effects on the stimulation effect, for example, stimulation current intensity, stimulation time, stimulation frequency, etc., which are not limited here.

[0025] Channel selection: In this application, channel selection refers to determining the specific path and electrode combination of the current during tES stimulation; in tES stimulation, the channel is usually composed of one or more pairs of electrodes, through which the current is applied to the scalp, thereby affecting the neural activity of the brain. Each channel can independently control parameters such as the intensity, polarity, and time of the current. For example, in bipolar stimulation, a channel consists of an anode and a cathode. The current flows from the anode, passes through the scalp and brain tissue, and then flows into the cathode. In multipolar stimulation, there can be multiple combinations of anodes and cathodes to form a complex current distribution.

[0026] Skin impedance: refers to the resistance encountered by the current when passing through the scalp and skin. Skin impedance affects the distribution of current in the scalp and brain. Higher impedance will cause uneven distribution of current on the surface of the skin, thereby reducing the depth and accuracy of tES stimulation. Conversely, lower impedance can make the current more evenly distributed in the brain, improving the effect of tES stimulation.

[0027] See also Figure 1 , Figure 1 1 is a structural block diagram of a multi-channel transcranial electrical stimulation device 100 provided in an embodiment of the present application. The multi-channel transcranial electrical stimulation device 100 includes: a control module 101, a digital-to-analog conversion module 102, a multi-channel current source module 103, a channel selection module 104, and an electrical stimulation module 105, wherein:

[0028] The first end of the control module 101 is connected to the first end of the digital-to-analog conversion module 102, the second end of the digital-to-analog conversion module 102 is connected to the first end of the multi-channel current source module 103, the second end of the multi-channel current source module 103 is connected to the first end of the channel selection module 104, the second end of the channel selection module 104 is connected to the first end of the electrical stimulation module 105, and the second end of the electrical stimulation module 105 is connected to the target object; the digital-to-analog conversion module 102 includes a plurality of first channels; the multi-channel current source module 103 includes a plurality of second channels, each second channel corresponds to a first channel; the channel selection module 104 includes a plurality of third channels, each third channel corresponds to a second channel; the electrical stimulation module 105 includes a plurality of electrode assemblies;

[0029] The control module 101 is used to obtain target basic physiological condition data corresponding to the target object; generate a corresponding target stimulation scheme according to the target basic physiological condition data; determine stimulation parameters corresponding to the target stimulation scheme to obtain at least one stimulation parameter; the at least one stimulation parameter includes the number of channels; determine a control instruction corresponding to the at least one stimulation parameter to obtain a target control instruction; control the multi-channel transcranial electrical stimulation device 100 to work according to the target control instruction to achieve multi-channel transcranial electrical stimulation of the target object; the target control instruction includes a first control instruction and a second control instruction;

[0030] In the embodiment of the present application, the stimulation parameters include at least one of the following: stimulation current intensity, stimulation duration, stimulation site, number of channels, etc., which are not limited here; the target basic physiological condition data may include at least one of the following: blood pressure data, sleep data, hormone data, etc., which are not limited here.

[0031] In a specific embodiment, the target object may be tested in real time through medical testing equipment to obtain the target's basic physiological condition data. For example, a chemiluminescence immunoassay analyzer may be used to detect hormone data, a sphygmomanometer may be used to measure blood pressure data, and so on. This is not limited here. Different measurement methods and equipment may be selected for testing according to different physiological condition data. Alternatively, authorization may be obtained from the target hospital, and the target's basic physiological condition data may be queried in the database of the target hospital. It should be explained that the target hospital is the hospital where the target object is treated.

[0032] Next, a corresponding target stimulation scheme can be generated according to the target basic physiological condition data; then, the corresponding stimulation parameters can be directly extracted from the target stimulation scheme to obtain at least one stimulation parameter. For example, assuming that the target stimulation scheme is to place electrodes on the bilateral frontal cortex of the target object, the current intensity is set to 1-1.5mA, the stimulation time is 20 minutes each time, and a single-channel tES stimulation is performed once a day with a stimulation frequency of 0Hz (direct current) for 10 consecutive days. Then, at least one stimulation parameter can be extracted therefrom. Specifically, the at least one stimulation parameter includes: the stimulation current intensity is 1-1.5mA, the stimulation time is 20 minutes, the stimulation site is the bilateral frontal cortex, the number of channels is 1, and other information is not limited here.

[0033] Furthermore, the control module 101 can generate corresponding control instructions based on the at least one stimulation parameter to obtain target control instructions. Specifically, the mapping relationship between preset stimulation parameters and control instructions can be pre-stored, and the target control instruction corresponding to the at least one stimulation parameter can be determined based on the mapping relationship; finally, the control module 101 can control the multi-channel transcranial electrical stimulation device 100 to operate according to the target control instruction, and perform tES stimulation on the target object according to the target stimulation scheme.

[0034] Optionally, the multi-channel transcranial electrical stimulation device 100 further includes an impedance detection module 106, the second end of the control module 101 is connected to the first end of the impedance detection module 106, and the second end of the impedance detection module 106 is connected to the target object. Figure 2 , Figure 2 1 is a structural block diagram of an impedance detection module 106 provided in an embodiment of the present application. The impedance detection module 106 includes: an ADC module 61, a preset current source 62, and an analog switch 63. The analog switch 63 may be a multi-channel analog switch. The multi-channel analog switch includes an input channel and multiple output channels, wherein:

[0035] The ADC module 61 is respectively connected to the preset current source 62 and the input channel of the multi-channel analog switch, and the multiple output channels are respectively connected to the multiple stimulation positions on the target object, and each stimulation position corresponds to an output channel; Figure 2 As shown, four stimulation positions (ie, four points above the preset common electrode 201) may be set on the target object, and the four stimulation positions are respectively connected to an output channel.

[0036] Among them, the impedance detection module 106 is used to obtain the stimulation position corresponding to each electrode assembly in the multiple electrode assemblies within the first preset time period to obtain multiple stimulation positions; input the preset current into the input channel of the analog switch 63 through the preset current source 62, and open the multiple output channels in sequence according to the preset time interval. The preset current flows into the head of the target object through the multiple output channels and flows out through the preset common electrode 201. The preset common electrode 201 is set at a preset position on the head of the target object; the voltage of the analog switch 63 is collected through the ADC module 61 to obtain the target voltage; the target skin impedance corresponding to the target object is determined according to the target voltage and the preset current, and the target skin impedance is transmitted to the control module 101.

[0037] In the embodiment of the present application, the first preset time period and the preset time interval can be preset in advance or defaulted; the preset current source 62 is a constant current source, for example, the preset current of the preset current source 62 can be 200 μA DC.

[0038] In a specific embodiment, the control module 101 may send the information of the above-mentioned multiple stimulation positions within the first preset time period to the impedance detection module 106, and then the preset current source 62 outputs the preset current, and the preset current flows into the input channel of the analog switch 63. The switch S of the analog switch 63 can be switched from S1 to S4 in sequence, and polled in sequence at a preset time interval (for example, 100ms). The preset current flows into the head of the target object through multiple output channels and flows to the ground through the preset common electrode 201. During this polling process, the voltage of the analog switch 63 can be collected by the ADC module 61 to obtain the target voltage, and the target voltage and the preset current can be calculated according to Ohm's law to obtain the target skin impedance. Then, the impedance detection module 106 can also transmit the target skin impedance to the control module 101.

[0039] Optionally, in acquiring the voltage of the analog switch 63 through the ADC module 61 to obtain the target voltage, the impedance detection module 106 is specifically used for:

[0040] A1. Within the first preset time period, sequentially collect the reference voltage of each output channel of the multiple output channels according to the preset time interval to obtain multiple reference voltages;

[0041] A2. determining an average voltage of the plurality of reference voltages;

[0042] A3, obtaining the target sampling rate corresponding to the ADC module 61;

[0043] A4. Determine the target impact factor corresponding to the target sampling rate;

[0044] A5. Adjust the average voltage according to the target impact factor to obtain the target voltage.

[0045] In the embodiment of the present application, within the first preset time period, the reference voltages of the above-mentioned multiple output channels are collected by the ADC module 61, and the voltage may be collected once every preset time interval, so that it can correspond to the channel switching time of the analog switch 63, and the voltage is collected once each time the channel is switched, thereby obtaining multiple reference voltages; then, the average voltage of the multiple reference voltages can be calculated; then, the target sampling rate corresponding to the ADC module 61 can be obtained, for example, the technical manual of the ADC module 61 can be queried to find out the target sampling rate; then, the target influence factor corresponding to the target sampling rate can be determined, specifically, the mapping relationship between the preset sampling rate and the influence factor can be pre-stored, and the target influence factor corresponding to the target sampling rate is determined based on the mapping relationship, and the value range of the target influence factor can be -0.3~0.3; finally, the average voltage can be adjusted according to the target influence factor, and the specific calculation formula is as follows:

[0046] Target voltage = average voltage × (1 + target impact factor);

[0047] The target voltage can be obtained according to the above formula.

[0048] In this way, by sequentially collecting multiple reference voltages corresponding to multiple output channels according to preset time intervals within a first preset time period; determining the average voltage of the multiple reference voltages; obtaining the target sampling rate corresponding to the ADC module 61; determining the target influence factor corresponding to the target sampling rate; adjusting the average voltage according to the target influence factor to obtain the target voltage, and averaging the multiple reference voltages to obtain the average voltage, the influence of random errors can be reduced, and, by considering the influence of the sampling rate and adjusting the average voltage according to the target influence factor, the error caused by the sampling rate can be compensated to a certain extent, thereby improving the accuracy of voltage measurement.

[0049] Optionally, in the aspect of generating a corresponding target stimulation scheme according to the target basic physiological condition data, the control module 101 is specifically used for:

[0050] B1. determining the target disease and target body parameters corresponding to the target basic physiological condition data;

[0051] B2. Determine the stimulation scheme corresponding to the target disease to obtain an initial stimulation scheme; the initial stimulation scheme includes an initial stimulation current intensity and an initial stimulation duration;

[0052] B3. Acquiring historical transcranial electrical stimulation data and historical physical parameters of the target object;

[0053] B4, determining the average stimulation duration corresponding to the historical transcranial electrical stimulation data;

[0054] B5. Determine a reference first optimization factor corresponding to the target skin impedance;

[0055] B6. determining a reference second optimization factor corresponding to the average stimulation duration;

[0056] B7, determining the difference between the target body parameter and the historical body parameter to obtain a target difference;

[0057] B8, determining a target fine-tuning factor corresponding to the target difference;

[0058] B9. Fine-tune the reference first optimization factor and the reference second optimization factor respectively according to the target fine-tuning factor to obtain a target first optimization factor and a target second optimization factor;

[0059] B10, optimizing the initial stimulation current intensity according to the target first optimization factor to obtain a target stimulation current intensity;

[0060] B11, optimizing the initial stimulation duration according to the target second optimization factor to obtain a target stimulation duration;

[0061] B12. Determine the target stimulation scheme according to the target stimulation current intensity and the target stimulation duration.

[0062] In the embodiments of the present application, the target disease may be at least one of the following: depression, anxiety, schizophrenia, etc., which are not limited here; the target physical parameters may include at least one of the following: heart rate, blood pressure, psychological state score, sleep quality index, etc., which are not limited here.

[0063] In a specific embodiment, the target disease and target body parameters corresponding to the target basic physiological condition data are determined. Specifically, the target basic physiological condition data can be analyzed to determine the target disease. For example, assuming that the target basic physiological condition data is analyzed and it is found that the target object has elevated cortisol levels and abnormal thyroid function, the target disease can be judged to be depression. Depression can affect the target object's psychological state score, so the target body parameters can be the psychological state score, and the target object can be psychologically evaluated to obtain the target body parameters. Then, the stimulation plan corresponding to the target disease can be determined to obtain the initial stimulation plan. Specifically, relevant medical literature, hospital databases, medical websites, etc. can be consulted to obtain research data on the target disease, and the initial stimulation plan can be determined based on the research data.

[0064] Furthermore, the historical transcranial electrical stimulation data and historical physical parameters of the target object can be obtained. Specifically, the historical transcranial electrical stimulation data and historical physical parameters can be queried from the database of the target hospital. Of course, the target object or the target doctor can be asked to obtain the historical transcranial electrical stimulation data and historical physical parameters from their description, wherein the target doctor is the target object's attending physician; then, the average stimulation duration corresponding to the historical transcranial electrical stimulation data can be determined. Specifically, the stimulation duration of each stimulation in the historical transcranial electrical stimulation data can be found to obtain multiple stimulation durations, and then the multiple stimulation durations are averaged to obtain the average stimulation duration; further, the reference first optimization factor corresponding to the target skin impedance can be determined, which can be a pre-stored mapping relationship between a preset skin impedance and a first optimization factor, and the reference first optimization factor corresponding to the target skin impedance is determined based on the mapping relationship, wherein the value range of the reference first optimization factor is -0.12~0.12, and the target skin impedance is detected by the impedance detection module 106.

[0065] Next, the reference second optimization factor corresponding to the average stimulation duration can also be determined. Similarly, the mapping relationship between the preset stimulation duration and the second optimization factor can be pre-stored, and the reference second optimization factor corresponding to the average stimulation duration can be determined based on the mapping relationship, wherein the value range of the reference second optimization factor is -0.2~0.2; Next, the difference between the target body parameters and the historical body parameters can be determined, and the specific calculation formula is as follows:

[0066] Target difference = target physical parameters - historical physical parameters;

[0067] According to the above formula, the target difference can be calculated; then, the target fine-tuning factor corresponding to the target difference can be determined. Specifically, a mapping relationship between a preset difference and a fine-tuning factor can be pre-stored, and the target fine-tuning factor corresponding to the target difference can be determined based on the mapping relationship, wherein the value range of the target fine-tuning factor is -0.3~0.3; then, the reference first optimization factor and the reference second optimization factor can be fine-tuned respectively according to the target fine-tuning factor, and the specific calculation formula is as follows:

[0068] Target first optimization factor = reference first optimization factor × (1 + target fine-tuning factor);

[0069] Target second optimization factor = reference second optimization factor × (1 + target fine-tuning factor);

[0070] According to the above formula, the target first optimization factor and the target second optimization factor can be calculated; then, the initial stimulation current intensity can be optimized according to the target first optimization factor to obtain the target stimulation current intensity, and the initial stimulation duration can be optimized according to the target second optimization factor to obtain the target stimulation duration. The specific calculation formula is as follows:

[0071] Target stimulation current intensity = initial stimulation current intensity × (1 + target first optimization factor);

[0072] Target stimulation duration = initial stimulation duration × (1 + target second optimization factor);

[0073] According to the above formula, the target stimulation current intensity and the target stimulation duration can be calculated; finally, the corresponding target stimulation scheme can be generated according to the target stimulation current intensity and the target stimulation duration.

[0074] In this way, by determining the target symptoms and target body parameters corresponding to the target basic physiological condition data, we can gain an in-depth understanding of the specific health problems of the target object. Different combinations of symptoms and body parameters reflect the individual's unique physiological state, providing data support for the subsequent formulation of stimulation plans. In addition, the initial stimulation plan is determined based on research on the target symptoms and existing clinical experience. However, each target object is unique, and the target difference between the target body parameters and the historical body parameters must also be considered. The plan is further optimized based on the target difference to make it more in line with individual needs, thereby improving the targeted nature of the stimulation plan.

[0075] The digital-to-analog conversion module 102 is used to receive a first control instruction from the control module 101; control multiple first channels to generate at least one first output voltage according to the first control instruction, and output the at least one first output voltage to the multi-channel current source module 103;

[0076] Optional, see Figure 3 , Figure 3 is a work flow chart of a digital-to-analog conversion module 102 provided in an embodiment of the present application, wherein the first control instruction includes first channel identification data and output voltage data, and in controlling the plurality of first channels to generate at least one first output voltage according to the first control instruction, the digital-to-analog conversion module 102 is specifically used for:

[0077] S301, determining a first channel among the plurality of first channels according to the first channel identification data, to obtain at least one first channel;

[0078] S302, determining a reference first output voltage corresponding to each first channel in the at least one first channel according to the output voltage data, to obtain at least one reference first output voltage;

[0079] S303, obtaining a target voltage conversion accuracy corresponding to the digital-to-analog conversion module 102;

[0080] S304, determining a first influence coefficient corresponding to the target voltage conversion accuracy;

[0081] S305, obtaining the target ambient temperature corresponding to the digital-to-analog conversion module 102;

[0082] S306, determining the difference between the target ambient temperature and the preset ambient temperature to obtain a target temperature difference;

[0083] S307, determining a target interference factor corresponding to the target temperature difference;

[0084] S308, adjusting the first influence coefficient according to the target interference factor to obtain a second influence coefficient;

[0085] S309: Adjust the at least one reference first output voltage according to the second influence coefficient to obtain the at least one first output voltage.

[0086] In an embodiment of the present application, the first channel identification data includes at least one first channel identification, and one first channel corresponds to a unique first channel identification; the output voltage data packet contains at least one output voltage, and each output voltage corresponds to a first channel identification; the preset ambient temperature can be preset or defaulted in advance, and the preset ambient temperature can be the optimal operating temperature of the digital-to-analog conversion module 102.

[0087] In a specific embodiment, a corresponding first channel can be selected from the above-mentioned multiple first channels according to at least one first channel identifier in the first channel identification data to obtain at least one first channel; then, the output voltage corresponding to the at least one first channel can be obtained from the output voltage data to obtain at least one output voltage, and then, the target voltage conversion accuracy corresponding to the digital-to-analog conversion module 102 can be obtained. Specifically, the target device model of the digital-to-analog conversion module 102 can be obtained first, and then the corresponding target voltage conversion accuracy can be determined according to the target device model. For example, a mapping relationship between a preset device model and a voltage conversion accuracy can be pre-stored, and the target voltage conversion accuracy corresponding to the target device model can be determined based on the mapping relationship.

[0088] Next, the first influence coefficient corresponding to the target voltage conversion accuracy can be determined. Specifically, a mapping relationship between a preset voltage conversion accuracy and an influence coefficient can be pre-stored, and the first influence coefficient corresponding to the target voltage conversion accuracy can be determined based on the mapping relationship. The value range of the first influence coefficient can be -0.12~0.12; Next, the target ambient temperature corresponding to the digital-to-analog conversion module 102 can be obtained. Specifically, a temperature sensor can be installed around the digital-to-analog conversion module 102, and the ambient temperature can be detected by the temperature sensor to obtain the target ambient temperature; Then, the difference between the target ambient temperature and the preset ambient temperature can be determined. The specific calculation formula is as follows:

[0089] Target temperature difference = target ambient temperature - preset ambient temperature;

[0090] According to the above formula, the target temperature difference can be obtained; then, the target interference factor corresponding to the target temperature difference can be determined. Specifically, a mapping relationship between a preset temperature difference and an interference factor can be pre-stored, and the target interference factor corresponding to the target temperature difference can be determined based on the mapping relationship. The value range of the target interference factor can be -0.3~0.3; then, the first influence coefficient can be adjusted according to the target interference factor. The specific calculation formula is as follows:

[0091] Second influence coefficient = first influence coefficient × (1 + target interference factor);

[0092] According to the above formula, the second influence coefficient can be obtained; finally, at least one reference first output voltage can be adjusted according to the second influence coefficient, and the specific calculation formula is as follows:

[0093] First output voltage a=reference first output voltage a×(1+second influence coefficient);

[0094] Among them, the reference first output voltage a is any one of the above-mentioned at least one reference first output voltage, and the first output voltage a is the first output voltage corresponding to the reference first output voltage a in at least one first output voltage; at least one first output voltage can be calculated according to the above formula.

[0095] In this way, at least one first channel among multiple first channels is determined according to the first channel identification data; at least one reference first output voltage corresponding to at least one first channel is determined according to the output voltage data; the target voltage conversion accuracy corresponding to the digital-to-analog conversion module 102 is obtained; the first influence coefficient corresponding to the target voltage conversion accuracy is determined; the target ambient temperature corresponding to the digital-to-analog conversion module 102 is obtained; the difference between the target ambient temperature and the preset ambient temperature is determined to obtain the target temperature difference; the target interference factor corresponding to the target temperature difference is determined; the first influence coefficient is adjusted according to the target interference factor to obtain the second influence coefficient; at least one reference first output voltage is adjusted according to the second influence coefficient to obtain at least one first output voltage. On the one hand, a specific first channel is determined according to the first channel identification data, and the reference first output voltage is determined thereby. This enables the system to perform precise voltage control on key channels according to specific application scenarios and requirements, thereby improving the efficiency of voltage control. On the other hand, by introducing the influence coefficient, the reference first output voltage can be corrected in the subsequent adjustment process to compensate for the error caused by the voltage conversion accuracy, thereby improving the accuracy of the voltage.

[0096] The multi-channel current source module 103 is used to generate at least one first output current according to at least one first output voltage, and output the at least one first output current to the channel selection module 104; each first output current corresponds to a first output voltage;

[0097] Optionally, the multi-channel current source module 103 includes a plurality of constant current source circuits, and each constant current source circuit corresponds to a second channel.

[0098] See also Figure 4 , Figure 4 : is a structural block diagram of a first constant current source circuit 31 provided in an embodiment of the present application. It can be seen that the first constant current source circuit 31 includes: a first instrument amplifier U1, a second instrument amplifier U2, a first resistor R1, and a load resistor RLoad; the first constant current source circuit 31 is any constant current source circuit among multiple constant current source circuits; wherein:

[0099] The first end (non-inverting input end) of the first instrument amplifier U1 is connected to the output end of the target first channel in the digital-to-analog conversion module 102, and the target first channel is the first channel corresponding to the first constant current source circuit 31 among the multiple first channels; the second end (reverse input end) of the first instrument amplifier U1 is connected to the preset reference source Vref; the third end of the first instrument amplifier U1 is respectively connected to the first end of the first resistor R1, the third end of the second instrument amplifier U2, and the second end of the second instrument amplifier U2; the second end of the first resistor R1 is respectively connected to the first end of the load resistor RLoad and the first end of the second instrument amplifier U2.

[0100] It should be explained that the second end of the load resistor RLoad may be grounded.

[0101] In the embodiment of the present application, the preset reference source Vref may be preset or defaulted in advance. For example, the preset reference source Vref may be a reference voltage source of 1.25V; the resistance value of the first resistor R1 may be 500Ω with an accuracy of 0.1%.

[0102] In a specific embodiment, since no gain resistor is provided in the first constant current source circuit 31, the operational amplifier gain is set to 1, so the output voltage of the first instrument amplifier U1 is:

[0103] V1=(U + -U - )×1=Uout-Uref;

[0104] Wherein, V1 is the output voltage of the first instrument amplifier U1; U + U and Uout both represent the voltage of the first terminal of the first instrument amplifier U1, that is, the output voltage of the target first channel; U - and Uref both represent the voltage at the second end of the first instrument amplifier U1, ie, the output voltage of the preset reference source Vref.

[0105] At the first resistor R1, according to Ohm's law:

[0106] Iout=(Uout-Uref) / R1=(U + -1.25V) / R1;

[0107] Wherein, Iout is the output current of the first constant current source circuit 31, that is, one of the at least one first output current mentioned above; R1 is the resistance value of the first resistor R1; it can be seen that when the voltage range of the target first channel output is 0~2.5V, a voltage between -1.25~1.25V will be generated across the first resistor R1, then according to the above formula, the range of Iout is -2.5mA~2.5mA, which can meet the output current requirements of common transcranial electrical stimulation. It should be explained that, limited by the accuracy of the first resistor R1 and the accuracy of other modules, the output current error of the first constant current source circuit 31 is about 2.5μA.

[0108] The channel selection module 104 is used to receive the second control instruction of the control module 101, and control at least one third channel among the plurality of third channels to be in an open state according to the second control instruction, and output at least one first output current to the electrical stimulation module 105 through the at least one third channel;

[0109] In a specific embodiment, the second control instruction may include second channel identification data and output current data. The channel selection module 104 can determine at least one third channel based on the second channel identification data, and can also determine at least one first output current based on the output current data. Then, the at least one third channel can be controlled to be in an on state, and the at least one first output current can flow out through the at least one third channel to reach the electrical stimulation module 105, wherein one first output current corresponds to one third channel.

[0110] Optionally, the digital-to-analog conversion module 102 includes an eight-channel digital-to-analog converter, and each channel of the eight-channel digital-to-analog converter can independently output a voltage to the multi-channel current source module 103 .

[0111] Optionally, the channel selection module 104 includes an analog switch chip, which may include four independently selected single-pole double-throw switches, that is, the number of third channels of the channel selection module 104 is 8, and these 8 third channels all adopt a break-before-make switching method to prevent instantaneous short circuits during channel switching. Specifically, break-before-make means that when switching channels, the currently connected channel is first disconnected, and then the target channel is closed. This ensures that only one channel is connected at any time, avoiding short circuits that may be caused by multiple channels being connected at the same time. The target channel is the third channel to be opened. For example, assuming switching from channel a to channel b, the break-before-make method will first disconnect the connection of channel a, and after confirming that no current flows through channel a, channel b will be closed to allow current to start flowing through channel b.

[0112] The electrical stimulation module 105 is used to determine the electrode assembly corresponding to each of the at least one first output current to obtain at least one electrode assembly; then, the target object is subjected to transcranial electrical stimulation with the corresponding first output current of the at least one first output current through the at least one electrode assembly, so that the target object generates corresponding transcranial electrical stimulation data. It should be explained that the transcranial electrical stimulation data can be collected through an electroencephalogram device.

[0113] Optionally, the first electrode assembly is in the shape of a ring, the inside of the ring of the first electrode assembly is an anode, and the outside of the ring of the first electrode assembly is a cathode; the first electrode assembly is any electrode assembly among the above-mentioned multiple electrode assemblies.

[0114] It can be seen that by implementing the multi-channel transcranial electrical stimulation device provided by the embodiment of the present invention, the control module obtains the target basic physiological condition data corresponding to the target object; generates a corresponding target stimulation scheme according to the target basic physiological condition data; determines the stimulation parameters corresponding to the target stimulation scheme to obtain at least one stimulation parameter; at least one stimulation parameter includes the number of channels; determines the control instruction corresponding to at least one stimulation parameter to obtain the target control instruction; controls the multi-channel transcranial electrical stimulation device to work according to the target control instruction to achieve multi-channel transcranial electrical stimulation of the target object. In this way, by obtaining the specific physiological condition data of the target object to generate a stimulation scheme, and selecting an appropriate number of channels according to the specific situation of the target object, it is possible to ensure that the stimulation scheme is highly personalized. Then, appropriate currents are output through these channels to perform tES stimulation on multiple brain regions of the target object to meet the specific needs of the target object, thereby improving the therapeutic effect of tES.

[0115] An embodiment of the present application also provides a multi-channel transcranial electrical stimulation system, which includes a multi-channel transcranial electrical stimulation device as described in any one of the above embodiments.

[0116] It should be noted that, for the aforementioned method embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the present application is not limited by the described order of actions, because according to the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily required by the present application.

[0117] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0118] In the several embodiments provided in the present application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only schematic, such as the division of the above-mentioned units, which is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, and the indirect coupling or communication connection of devices or units can be electrical or other forms.

[0119] The units described above as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0120] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units.

[0121] If the above-mentioned integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable memory. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product. The computer software product is stored in a memory, including a number of instructions to enable a computer device (which can be a personal computer, server or network device, etc.) to execute all or part of the steps of the above-mentioned methods in each embodiment of the present application. The aforementioned memory includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, disk or optical disk and other media that can store program codes.

[0122] The embodiments of the present application are introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and core idea of ​​the present application. At the same time, for general technical personnel in this field, according to the idea of ​​the present application, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A multi-channel transcranial electrical stimulation device, characterized in that: The device comprises: a control module, a digital-to-analog conversion module, a multi-channel current source module, a channel selection module, and an electrical stimulation module, wherein: The first end of the control module is connected to the first end of the digital-to-analog conversion module, the second end of the digital-to-analog conversion module is connected to the first end of the multi-channel current source module, the second end of the multi-channel current source module is connected to the first end of the channel selection module, the second end of the channel selection module is connected to the first end of the electrical stimulation module, and the second end of the electrical stimulation module is connected to the target object; the digital-to-analog conversion module includes a plurality of first channels; the multi-channel current source module includes a plurality of second channels, each second channel corresponds to a first channel; the channel selection module includes a plurality of third channels, each third channel corresponds to a second channel; the electrical stimulation module includes a plurality of electrode assemblies; The control module is used to obtain the target basic physiological condition data corresponding to the target object; generate a corresponding target stimulation scheme according to the target basic physiological condition data; determine the stimulation parameters corresponding to the target stimulation scheme to obtain at least one stimulation parameter; the at least one stimulation parameter includes the number of channels; determine the control instruction corresponding to the at least one stimulation parameter to obtain a target control instruction; control the multi-channel transcranial electrical stimulation device to work according to the target control instruction to achieve multi-channel transcranial electrical stimulation of the target object; the target control instruction includes a first control instruction and a second control instruction; the target basic physiological condition data includes at least one of the following: blood pressure data, sleep data, hormone data; The digital-to-analog conversion module is configured to receive the first control instruction of the control module; control the plurality of first channels to generate at least one first output voltage according to the first control instruction, and output the at least one first output voltage to the multi-channel current source module; The multi-channel current source module is used to generate at least one first output current according to the at least one first output voltage, and output the at least one first output current to the channel selection module; each first output current corresponds to a first output voltage; The channel selection module is used to receive the second control instruction of the control module, and control at least one third channel of the plurality of third channels to be in an open state according to the second control instruction, and output the at least one first output current to the electrical stimulation module through the at least one third channel; The electrical stimulation module is used to determine the electrode assembly corresponding to the at least one first output current, obtain at least one electrode assembly, each electrode assembly corresponds to a first output current; perform transcranial electrical stimulation on the target object through the at least one electrode assembly with a corresponding first output current among the at least one first output current, so as to obtain corresponding transcranial electrical stimulation data; Wherein, the multi-channel transcranial electrical stimulation device further includes an impedance detection module, the second end of the control module is connected to the first end of the impedance detection module, the second end of the impedance detection module is connected to the target object, the impedance detection module includes: an ADC module, a preset current source, and an analog switch, the analog switch includes a multi-channel analog switch, and the multi-channel analog switch includes an input channel and multiple output channels, wherein: The ADC module is respectively connected to the preset current source and the input channel of the multi-channel analog switch, and the multiple output channels are respectively connected to multiple stimulation positions on the target object, and each stimulation position corresponds to an output channel; The impedance detection module is used to obtain the stimulation position corresponding to each electrode assembly in the multiple electrode assemblies within a first preset time period to obtain the multiple stimulation positions; input a preset current into the input channel of the analog switch through the preset current source, and sequentially open the multiple output channels according to preset time intervals, so that the preset current flows into the head of the target object through the multiple output channels and flows out through a preset common electrode, and the preset common electrode is set at a preset position on the head of the target object; collect the voltage of the analog switch through the ADC module to obtain a target voltage; determine the target skin impedance corresponding to the target object according to the target voltage and the preset current, and transmit the target skin impedance to the control module; Wherein, in acquiring the voltage of the analog switch through the ADC module to obtain the target voltage, the impedance detection module is specifically used for: In the first preset time period, the reference voltage of each output channel of the multiple output channels is collected in sequence according to the preset time interval to obtain multiple reference voltages; determining an average voltage of the plurality of reference voltages; Obtaining a target sampling rate corresponding to the ADC module; Determining a target impact factor corresponding to the target sampling rate; Adjusting the average voltage according to the target impact factor to obtain the target voltage; Wherein, in the aspect of generating a corresponding target stimulation scheme according to the target basic physiological condition data, the control module is specifically used for: Determine a target disease and a target body parameter corresponding to the target basic physiological condition data; the target disease includes at least one of the following: depression, anxiety, schizophrenia; the target body parameter includes at least one of the following: heart rate, blood pressure, psychological state score, sleep quality index; Determine a stimulation scheme corresponding to the target disease to obtain an initial stimulation scheme; the initial stimulation scheme includes an initial stimulation current intensity and an initial stimulation duration; Acquiring historical transcranial electrical stimulation data and historical physical parameters of the target object; Determining an average stimulation duration corresponding to the historical transcranial electrical stimulation data; Determining a reference first optimization factor corresponding to the target skin impedance; Determining a reference second optimization factor corresponding to the average stimulation duration; Determine the difference between the target body parameter and the historical body parameter to obtain a target difference; Determine the target fine-tuning factor corresponding to the target difference; specifically: pre-store a mapping relationship between a preset difference and a fine-tuning factor, and determine the target fine-tuning factor corresponding to the target difference based on the mapping relationship; The reference first optimization factor and the reference second optimization factor are respectively fine-tuned according to the target fine-tuning factor to obtain a target first optimization factor and a target second optimization factor; specifically: Target first optimization factor = reference first optimization factor × (1 + target fine-tuning factor); Target second optimization factor = reference second optimization factor × (1 + target fine-tuning factor); The initial stimulation current intensity is optimized according to the target first optimization factor to obtain the target stimulation current intensity; specifically: Target stimulation current intensity = initial stimulation current intensity × (1 + target first optimization factor); Optimizing the initial stimulation duration according to the target second optimization factor to obtain a target stimulation duration; Determining the target stimulation scheme according to the target stimulation current intensity and the target stimulation duration; The first control instruction includes first channel identification data and output voltage data. In controlling the plurality of first channels to generate at least one first output voltage according to the first control instruction, the digital-to-analog conversion module is specifically configured to: Determine a first channel among the plurality of first channels according to the first channel identification data to obtain at least one first channel; Determine a reference first output voltage corresponding to each first channel in the at least one first channel according to the output voltage data to obtain at least one reference first output voltage; Obtaining a target voltage conversion accuracy corresponding to the digital-to-analog conversion module; Determining a first influence coefficient corresponding to the target voltage conversion accuracy; Obtaining a target ambient temperature corresponding to the digital-to-analog conversion module; Determine the difference between the target ambient temperature and the preset ambient temperature to obtain a target temperature difference; Determining a target interference factor corresponding to the target temperature difference; Adjusting the first influence coefficient according to the target interference factor to obtain a second influence coefficient; The at least one reference first output voltage is adjusted according to the second influence coefficient to obtain the at least one first output voltage.

2. The device according to claim 1, characterized in that The multi-channel current source module includes multiple constant current source circuits, each of which corresponds to a second channel; the first constant current source circuit includes: a first instrument amplifier, a second instrument amplifier, a first resistor, and a load resistor; the first constant current source circuit is any constant current source circuit among the multiple constant current source circuits; wherein: The first end of the first instrument amplifier is connected to the output end of the target first channel in the digital-to-analog conversion module, and the target first channel is the first channel corresponding to the first constant current source circuit among the multiple first channels; the second end of the first instrument amplifier is connected to a preset reference source; the third end of the first instrument amplifier is respectively connected to the first end of the first resistor, the third end of the second instrument amplifier, and the second end of the second instrument amplifier; the second end of the first resistor is respectively connected to the first end of the load resistor and the first end of the second instrument amplifier.

3. The device according to claim 1, characterized in that The digital-to-analog conversion module includes an eight-channel digital-to-analog converter, and each channel of the eight-channel digital-to-analog converter can independently output a voltage to the multi-channel current source module.

4. The device according to claim 3, characterized in that The channel selection module includes an analog switch chip, which includes four independently selectable single-pole double-throw switches. The multiple third channels all adopt a break-before-make switching method to prevent instantaneous short circuits from occurring during channel switching.

5. The device according to claim 1, characterized in that The first electrode assembly is in the shape of a circular ring, the inside of the circular ring of the first electrode assembly is an anode, and the outside of the circular ring of the first electrode assembly is a cathode; the first electrode assembly is any electrode assembly among the multiple electrode assemblies.

6. A multi-channel transcranial electrical stimulation system, characterized in that: The system comprises a multi-channel transcranial electrical stimulation device as described in any one of claims 1-5.

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