Preparation method of honey paste for eliminating accumulation and relieving cough

Abstract

The invention relates to the technical field of health food, and specifically discloses a method for preparing a honey paste for eliminating accumulation and relieving cough, which is prepared by sequentially extracting and concentrating the following prescriptions: 45g of Fritillaria cirrhosa, 168g of dried orange peel, 168g of Platycodon grandiflorum, 95g of Schisandra chinensis, 77g of Radish Seed, 77g of Pinellia ternata, 95g of Polygala tenuifolia, 38g of Ephedra sinica, 77g of Hawthorn, 77g of Areca nut, 27g of Licorice extract, 4.4g of Menthol, and honey; wherein, Fritillaria cirrhosa and dried orange peel are subjected to water extraction at 70-75°C to obtain filtrate A; Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn and Areca nut are subjected to water extraction at 80-85°C to obtain filtrate B, and the filtrate A and the filtrate B are mixed and concentrated; wherein, the water extraction process comprises decocting three times with 8 times the amount of water, and the decocting time for each time is 30-90min. The invention can solve the problem that the existing preparation method leads to low content of effective components of tangerine peel in the detoxifying and antitussive medicine.

Description

Technical Field

[0001] The invention relates to the technical field of health food, and in particular to a method for preparing a honey paste for eliminating accumulation and relieving cough. Background Art

[0002] Antitussive and cough medicines usually contain many Chinese medicinal materials such as Huang extract, Chuanbei, Tangerine peel, Platycodon grandiflorum, Schisandra chinensis, Licorice extract, Pinellia ternata, Polygala tenuifolia, etc. Among them, Chuanbei and Tangerine peel are the main medicines, Chuanbei has the effect of relieving cough, etc. Tangerine peel mainly contains hesperidin, which has the effects of regulating qi and strengthening spleen, drying dampness and resolving phlegm.

[0003] Existing cough-relieving and antitussive drugs are usually decoctions, which have high preservation requirements and are inconvenient to carry. Existing cough-relieving and antitussive drugs are usually prepared by water extraction: yellow extract, Sichuan fritillary bulb, tangerine peel, platycodon, schisandra chinensis, liquorice extract, French pinellia tuber, polygala tenuifolia, etc. are mixed according to the formula amount and added to water for decoction, and the filtrate obtained is the cough-relieving and antitussive drug.

[0004] The temperature and time of decoction will affect the dissolution of the active ingredients. Using the existing water extraction method will result in a lower content of the active ingredient (hesperidin) in tangerine peel in the antitussive and cough medicine. Summary of the invention

[0005] The invention aims to provide a method for preparing a honey paste for eliminating accumulation and relieving cough, so as to solve the problem that the existing preparation method leads to a low content of effective components of tangerine peel in the medicine for eliminating accumulation and relieving cough, and the method is easy to carry.

[0006] The present invention is achieved through the following technical solutions:

[0007] A preparation method of a honey paste for eliminating stagnation and relieving cough, the prescription of the honey paste for eliminating stagnation and relieving cough is:

[0008] Fritillaria 45g, dried orange peel 168g, Platycodon grandiflorum 168g, Schisandra 95g, Radish seed 77g, Pinellia 77g, Polygala 95g, Ephedra 38g, Hawthorn 77g, Areca 77g, Licorice extract 27g, Menthol 4.4g, Honey;

[0009] The preparation method comprises the following steps:

[0010] S1, Fritillaria cirrhosa and dried orange peel were extracted with water at 70-75°C to obtain filtrate A; Platycodon grandiflorum, Schisandra chinensis, Radish seeds, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinellia and Areca catechu were extracted with water at 80-85°C to obtain filtrate B;

[0011] The water extraction process is to add 8 times the amount of water and boil for 3 times, and each boiling time is 30-90 minutes;

[0012] S2, after evenly mixing filtrate A and filtrate B, concentrating and cooling to obtain a concentrated solution;

[0013] S3. Add liquorice extract, menthol and honey to the concentrated solution obtained in step S2, mix well, and adjust the pH value to 4.5-7.5 to obtain a honey paste for eliminating accumulation and relieving cough.

[0014] The prior art for decocting Chinese medicinal materials is to add all the Chinese medicinal materials and water in the prescription into an extraction tank in proportion for decoction (one-pot decoction), and the decoction temperature is basically 100°C, that is, the liquid in the extraction tank is always in a boiling state during the decoction process. For example, the authorized patent CN112841573B discloses a preparation method of a paste with lung-clearing and cough-relieving effects, which is to boil all the Chinese medicinal materials, specifically, to boil the root of Peucedanum chinense, Perilla seed, Rhizoma Anemarrhenae, Semen Lepidii, Apricot kernel, Platycodon grandiflorum and Citrus aurantium in one pot, and extract them twice, and each extraction is to add 3-5 times the amount of water of the Chinese medicinal materials, and boil them for 0.5-1 hour in a slightly boiling state.

[0015] Although decoction at 100°C can improve the extraction efficiency of Chinese medicinal materials, the decoction temperature, decoction time, water dosage, extraction times, etc. of Chinese medicinal materials will affect the dissolution of effective ingredients. Too low a temperature will lead to lower dissolution of effective ingredients, and too high a temperature will lead to degradation of effective ingredients. Appropriate decoction time can ensure that the effective ingredients are fully extracted. Too short a decoction time will lead to lower dissolution of effective ingredients. Too long a time may lead to loss of ingredients.

[0016] Therefore, in order to increase the content of effective ingredients in Chinese medicinal materials after decoction, it is necessary to consider the optimal decoction temperature and decoction time of each Chinese medicinal material in the prescription, and consider the preparation time and cost of the finished product as a whole, and it is necessary to reasonably design the decoction method of each medicinal material in the prescription.

[0017] The Chuanbei and dried tangerine peel of the prescription of the Xiaoji Zhike honey paste of the present invention are the main medicines, and the optimal decoction temperature of Chuanbei and dried tangerine peel is lower than that of other medicinal materials. In addition, the dissolution of hesperidin, an effective ingredient of dried tangerine peel, is greatly affected by temperature, and hesperidin plays an important role in the efficacy of the Xiaoji Zhike honey paste. Therefore, when preparing the Xiaoji Zhike honey paste of the above prescription, it is necessary to ensure the dissolution of hesperidin.

[0018] The invention obtains the optimal water extraction temperature of Fritillaria cirrhosa, dried orange peel, Platycodon grandiflorum, Schisandra chinensis, Radish seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca nut through experiments, wherein the optimal water extraction temperature of Fritillaria cirrhosa and dried orange peel is 70-75 DEG C; the optimal water extraction temperature of Platycodon grandiflorum, Schisandra chinensis, Radish seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca nut is 80-85 DEG C.

[0019] Therefore, when preparing the Xiaoji Zhike honey paste, the present invention first determines the optimal water extraction temperature of different Chinese medicinal materials, and then determines the decoction time, the amount of water used, and the number of extractions according to the optimal water extraction temperature. The present invention decocts Fritillaria cirrhosa and dried tangerine peel in one pot; Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca catechu in another pot, and none of them are decocted at 100° C., Fritillaria cirrhosa and dried tangerine peel are decocted at 70-75° C., and Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca catechu at 80-85° C., so that the problem of loss of effective components of various Chinese medicinal materials in the prescription caused by decoction at 100° C., especially the problem of loss of hesperidin, an effective component of dried tangerine peel, can be effectively solved.

[0020] That is, the present invention is based on the prescription of the honey-refined paste for eliminating accumulation and relieving cough, fully considering the composition of the main medicine and the auxiliary medicine in the prescription, as well as the properties of each Chinese medicinal material, and in combination with the purpose of the present invention to increase the content of hesperidin (the active ingredient of tangerine peel) in the honey-refined paste for eliminating accumulation and relieving cough, adopts separate pot extraction, and considering the time and cost issues, does not use a single medicinal material for separate decoction; instead, it is boiled in two pots.

[0021] The present invention adopts two pots for separate decoction, and each pot has a correspondingly designed extraction temperature, water addition amount, extraction time and extraction times, which can increase the content of hesperidin (the effective component of tangerine peel) in the Xiaoji Zhike honey paste.

[0022] Furthermore, the dosage form prepared by the present invention is a paste, which is more convenient to carry than the existing decoction for relieving cough.

[0023] In a preferred embodiment, in step S1, the preparation process of filtrate A is:

[0024] Put Fritillaria cirrhosa and dried tangerine peel into an extraction tank, add 8 times the amount of water based on the total weight of Fritillaria cirrhosa and dried tangerine peel, heat to boiling, then cool to 70-75°C, and boil for 30-90 minutes; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 70-75°C, and boil for 30-90 minutes; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 70-75°C, and boil for 30-90 minutes; filter to obtain a third filtrate, and evenly mix the first filtrate, the second filtrate and the third filtrate to obtain filtrate A.

[0025] In a preferred embodiment, Sichuan Fritillaria and dried orange peel are pretreated:

[0026] After the Fritillaria chuanxiong and dried tangerine peel are mixed, they are first heated in a microwave, and then crushed and sieved through 60-80 meshes in sequence to obtain Fritillaria chuanxiong and dried tangerine peel powder, which is used for subsequent decoction.

[0027] The crushing process can increase the contact area between each Chinese medicinal material and water during water extraction, which is beneficial to improving the extraction efficiency; and by performing microwave heating before the crushing process, microwaves can be used to create microcracks in the Chinese medicinal materials, which is beneficial to improving the crushing effect, and the powder after crushing also has microcracks, which can further improve the extraction efficiency.

[0028] In a preferred embodiment, in step S1, the preparation process of filtrate B is:

[0029] Put platycodon, schisandra, radish seeds, pinellia, polygala, ephedra, hawthorn and areca into an extraction tank; add 8 times the amount of water according to the total weight of platycodon, schisandra, radish seeds, pinellia, polygala, ephedra, hawthorn and areca, heat to boiling, then cool to 80-85°C, and boil for 30-90 minutes; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 80-85°C, and boil for 30-90 minutes; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 80-85°C, and boil for 30-90 minutes; filter to obtain a third filtrate, mix the first filtrate, the second filtrate and the third filtrate evenly to obtain filtrate B.

[0030] In a preferred embodiment, Platycodon grandiflorum, Schisandra chinensis, Radish seeds, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinnatifida and Areca catechu are mixed and first heated in a microwave, and then crushed and sieved with 60-80 mesh in sequence to obtain a mixed powder, which is used for subsequent decoction.

[0031] In a preferred embodiment, in step S1, the decoction time for each time is 45-60 minutes.

[0032] In a preferred embodiment, in step S3, the pH value is adjusted to 6.0.

[0033] In a preferred embodiment, when preparing filtrate A and filtrate B, a water extraction tank is used for decoction, and the water extraction tank includes a detachably connected tank body and a tank cover, and a stirring mechanism;

[0034] The tank body is provided with an interlayer, the bottom of the interlayer is provided with an electric heating wire, and the bottom shape of the tank body is hemispherical;

[0035] The stirring mechanism comprises a motor, a vertical rotating shaft, a bevel gear, an arc-shaped disturbance plate, a connecting rod, a mounting seat and a horizontal rotating shaft;

[0036] The motor is installed on the top of the tank cover, one end of the vertical rotating shaft passes through the tank cover and is connected to the power output shaft of the motor, and the other end is placed in the tank body; the bevel gear is arranged on the vertical rotating shaft; one end of the horizontal rotating shaft is rotatably connected to the vertical rotating shaft, and the horizontal rotating shaft is vertically arranged to the vertical rotating shaft, and the mounting seat is installed on the horizontal rotating shaft, and the mounting seat is provided with a gear meshing with the bevel gear; the arc-shaped disturbance plate is connected to the horizontal rotating shaft through a connecting rod, and when the arc-shaped disturbance plate rotates to the bottom of the tank body, the arc-shaped disturbance plate can scrape the medicinal materials at the bottom of the tank body.

[0037] In order to achieve rapid temperature rise in the water extraction tank, the existing technology uses an interlayer for decoction, and an electric heating wire is arranged at the bottom of the interlayer. During decoction, the water extraction tank is rapidly heated up by the combined effect of the heating medium introduced into the interlayer and the electric heating wire. A stirring mechanism is arranged in the water extraction tank to improve the water extraction efficiency. The stirring mechanism includes a stirring shaft, and a plurality of stirring blades are arranged on the stirring shaft. The stirring blades disturb the mixture of water and Chinese medicinal materials in the water extraction tank to improve the water extraction efficiency.

[0038] Since the present invention also needs to heat the water and Chinese medicinal materials in the water extraction tank to boiling before cooling and decocting, it is necessary to use a heating medium and an electric heating wire in combination to achieve rapid heating to shorten the time to reach boiling. In addition, the heating medium and the electric heating wire are used in combination to maintain the water extraction temperature during the decocting process, which can avoid the use of a heating medium with an excessively high temperature.

[0039] However, since the prescription of the Xiaoji Zhike Honey Refined Paste of the present invention contains tangerine peel, the effective ingredient hesperidin in tangerine peel is greatly affected by temperature. When the overall temperature in the water extraction tank is controlled at 70-75°C, the temperature of the heating medium needs to be higher than 70-75°C and the temperature of the electric heating wire needs to be higher than 70-75°C. This will cause the temperature of the water and Chinese medicinal materials near the inner wall and bottom of the tank to be higher than the temperature in other areas. In particular, the temperature of the water and Chinese medicinal materials near the bottom of the tank is higher. Although the conventional stirring mechanism (stirring shaft plus stirring blades) has a certain disturbing effect on the water and Chinese medicinal materials, the disturbing effect has a certain effect on reducing the temperature of the water and Chinese medicinal materials near the inner wall of the tank, but has little effect on the bottom of the water extraction tank. As the decoction time increases, the Chinese medicinal materials are infiltrated by water, and some of the denser Chinese medicinal materials will be deposited at the bottom of the tank. Especially when powdered Chinese medicinal materials are used for water extraction, more Chinese medicinal materials will be deposited at the bottom of the tank. The existing stirring mechanism cannot disturb the Chinese medicinal materials at the bottom of the tank, resulting in the temperature of the Chinese medicinal materials at the bottom of the tank being too high, causing damage to the effective ingredients.

[0040] The water extraction tank of the present invention has structural improvements on the stirring mechanism used:

[0041] The vertical rotating shaft in the stirring mechanism of the present invention is driven to rotate by a motor, and the rotating mode is to rotate around the central axis of the vertical rotating shaft. Since the bevel gear and the gear on the mounting seat are meshed, when the vertical rotating shaft rotates, the horizontal rotating shaft is driven to rotate under the transmission action of the bevel gear and the gear, and then the arc-shaped disturbance plate is driven to rotate. Through the 360° circumferential rotation of the vertical rotating shaft in the horizontal direction and the 360° circumferential rotation of the horizontal rotating shaft in the vertical direction, the arc-shaped disturbance plate is realized to realize a three-dimensional 360° rotation; the three-dimensional 360° rotation means that the arc-shaped disturbance plate follows the 360° circumferential rotation of the vertical rotating shaft while following the 360° circumferential rotation of the vertical rotating shaft in the horizontal direction, thereby realizing that the arc-shaped disturbance plate can rotate at various positions at the bottom of the tank body. Since the arc-shaped disturbance plate can scrape the medicinal materials at the bottom of the tank body, during the rotation of the arc-shaped disturbance plate, the medicinal materials at the bottom of the tank body drive other parts of the sub-tank body, so as to prevent the same medicinal materials from being affected by high temperature for a long time at the bottom of the tank body.

[0042] In order to enable the arc-shaped disturbance plate to scrape the medicinal materials at various positions on the bottom of the tank body, the bottom of the tank body is configured to be in a hemispherical shape, so that the curvature of the bottom of the tank body changes evenly.

[0043] In a preferred embodiment, the arc-shaped disturbance plate includes an arc-shaped plate and a vertical plate; the shape of the arc-shaped plate matches the bottom shape of the tank body, and when the arc-shaped disturbance plate rotates to the bottom of the tank body, the bottom of the arc-shaped plate contacts the bottom of the tank body, and the vertical plate is arranged at the rear end of the top of the arc-shaped plate, and the rear end specifically refers to the end opposite to the end that first contacts the bottom of the tank body when the arc-shaped disturbance plate rotates to the bottom of the tank body.

[0044] The present invention forms a certain accommodating space between the vertical plate and the arc-shaped plate by arranging the vertical plate, so that more medicinal materials on the bottom wall of the tank body can be scraped to other positions of the tank body.

[0045] In a preferred embodiment, an annular groove is provided at the lower part of the vertical rotating shaft near the bottom of the tank body, and the bottom of the annular groove forms a sliding rod with a diameter smaller than the diameter of the vertical rotating shaft. A sliding disk is sleeved on the sliding rod, and there is a gap between the sliding disk and the sliding rod. The axial thickness of the sliding disk is smaller than the axial length of the sliding rod.

[0046] When the vertical shaft rotates, the sliding disk on the sliding rod rotates under the action of centrifugal force and can slide up and down on the sliding rod. Under the action of the sliding disk, the medicinal materials at the bottom of the tank body directly below the vertical shaft are pushed to the outside where they can be scraped by the arc-shaped disturbance plate, avoiding dead corners that cannot be scraped by the arc-shaped disturbance plate.

[0047] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0048] The invention decocts Fritillaria chuanxiong and dried orange peel in one pot, and decocts Platycodon grandiflorum, Schisandra chinensis, Radish seeds, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca nut in another pot, that is, the whole prescription medicinal materials are decocted in two pots, and neither of them is decocted at 100 DEG C, Fritillaria chuanxiong and dried orange peel are decocted at 70-75 DEG C, and Platycodon grandiflorum, Schisandra chinensis, Radish seeds, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca nut are decocted at 80-85 DEG C, so that the problem of loss of effective components of various Chinese medicinal materials in the prescription caused by decoction at 100 DEG C, especially the problem of loss of hesperidin, an effective component of dried orange peel, can be effectively solved. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] The drawings described herein are used to provide a further understanding of the embodiments of the present invention, constitute a part of this application, and do not constitute a limitation of the embodiments of the present invention. In the drawings:

[0050] Figure 1 It is a structural schematic diagram of the water extraction tank of the present invention;

[0051] Figure 2 for Figure 1 A partial enlarged view;

[0052] Figure 3 for Figure 1 A partial enlarged view of point B;

[0053] Figure 4 It is a structural schematic diagram of an existing water extraction tank.

[0054] Marks and corresponding parts names in the attached drawings:

[0055] 1-tank body; 2-tank cover; 3-interlayer; 4-motor; 5-vertical shaft; 6-bevel gear; 7-arc disturbance plate; 8-connecting rod; 9-mounting seat; 10-horizontal shaft; 11-electric heating wire; 12-rotating shaft; 13-fixing bolt; 51-annular groove; 52-sliding plate; 71-arc plate; 72-vertical plate. DETAILED DESCRIPTION

[0056] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the embodiments and drawings. The schematic implementation mode of the present invention and its description are only used to explain the present invention and are not intended to limit the present invention. The embodiments described below are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0057] In the following description, a large number of specific details are set forth in order to provide a thorough understanding of the present invention. However, it is apparent to those of ordinary skill in the art that these specific details do not have to be employed to practice the present invention. In other embodiments, in order to avoid confusing the present invention, known structures, materials or methods are not specifically described. The materials, instruments and reagents used in the following examples, unless otherwise specified, can be obtained from commercial sources. The technical means used in the examples, unless otherwise specified, are conventional means well known to those skilled in the art.

[0058] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0059] Embodiment 1:

[0060] In this embodiment, the dosage of each Chinese medicinal material in the prescription is amplified by 10 times for the convenience of testing. Since the dosage of menthol and honey is small, Chuanbei, dried tangerine peel, Platycodon, Schisandra chinensis, Radish seed, Pinellia ternata, Polygala tenuifolia, Ephedra, Hawthorn, Areca nut and Licorice extract are used as the feeding amount. The theoretical feeding amount of this embodiment is 9440g.

[0061] A honey-refined paste for eliminating accumulation and relieving cough is obtained by sequentially extracting with water and concentrating the following prescriptions;

[0062] 450g of Fritillaria cirrhosae, 1680g of dried tangerine peel, 1680g of Platycodon grandiflorum, 950g of Schisandra chinensis, 770g of Radish Seed, 770g of Pinellia ternata, 950g of Polygala tenuifolia, 380g of Ephedra sinica, 770g of Crataegus pinellia, 770g of Areca nut, 270g of Licorice extract, 4.40g of menthol, and honey. The amount of honey is determined according to the subsequent fixed volume treatment;

[0063] Among them, Fritillaria cirrhosa and dried tangerine peel are water-extracted at 72°C, during which the temperature can fluctuate between 70-75°C, to obtain filtrate A; Platycodon grandiflorum, Schisandra chinensis, Radish seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinellia and Areca catechu are water-extracted at 82°C, during which the temperature can fluctuate between 80-85°C, to obtain filtrate B, and filtrate A and filtrate B are mixed and concentrated; wherein the water extraction process is to add 8 times the amount of water and decoct for 3 times, and the decoction time for each time is 60 minutes.

[0064] The preparation method of the cough-relieving honey paste of the present embodiment comprises the following steps:

[0065] S1, preparing filtrate A and filtrate B respectively;

[0066] The preparation process of filtrate A is:

[0067] Put Fritillaria cirrhosa and dried tangerine peel into an extraction tank, add 8 times the amount of water based on the total weight of Fritillaria cirrhosa and dried tangerine peel, heat to boiling, then cool to 72°C, and boil for 60 minutes; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 72°C, and boil for 60 minutes; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 72°C, and boil for 60 minutes; filter to obtain a third filtrate, mix the first filtrate, the second filtrate and the third filtrate evenly to obtain filtrate A.

[0068] The preparation process of filtrate B is:

[0069] Put Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca nut into an extraction tank; add 8 times the amount of water based on the total weight of Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Hawthorn fruit and Areca nut, heat to boiling, then cool to 82°C, and boil for 60 minutes; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 82°C, and boil for 60 minutes; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 82°C, and boil for 60 minutes; filter to obtain a third filtrate, mix the first filtrate, the second filtrate and the third filtrate evenly to obtain filtrate B.

[0070] Among them, water extraction tanks such as Figure 4 As shown, the water extraction tank includes a detachably connected tank body 1 and a tank cover 2, and a stirring mechanism; the tank body 1 is provided with an interlayer 3, and an electric heating wire 11 is provided at the bottom of the interlayer 3; the stirring mechanism includes a motor 4, a stirring shaft and stirring blades. The stirring mechanism is a conventional stirring structure, and a plurality of stirring blades are provided on the stirring shaft to achieve stirring of water and Chinese medicinal materials in the water extraction tank, thereby improving the water extraction efficiency.

[0071] S2, after evenly mixing filtrate A and filtrate B, concentrating the mixture to a relative density of 1.30 (70°C), standing and cooling the mixture to obtain a concentrated solution;

[0072] S3. Add liquorice extract and menthol to the concentrated solution obtained in step S2, stir and mix thoroughly, add honey to 10 L, mix evenly, and adjust the pH value to 6.0 with NaOH to obtain a honey paste for eliminating accumulation and relieving cough.

[0073] The recipe of this example was tested in three batches, and the results are shown in Table 1:

[0074] Table 1

[0075]

[0076] Note: Each bottle contains 100 mL.

[0077] The quality of the three batches of pilot samples was tested in accordance with the relevant provisions of the quality standard of Xiaoji Zhike Mi Lian Gao preparations, and the results are shown in Table 2:

[0078] Table 2

[0079]

[0080] Embodiment 2:

[0081] This embodiment is based on Embodiment 1, and differs from Embodiment 1 in that:

[0082] Before water extraction, Fritillaria cirrhosa, dried orange peel, Platycodon grandiflorum, Schisandra chinensis, Radish seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinnatifida and Areca catechu were all pretreated: firstly microwave heating, then crushing and 80-mesh sieving in turn.

[0083] Specifically: when preparing filtrate A, the Fritillaria cirrhosa and tangerine peel are mixed and first heated by microwave, and then crushed and sieved through 80 meshes in sequence to obtain Fritillaria cirrhosa and tangerine peel powder, which is used for subsequent decoction.

[0084] Specifically: when preparing filtrate B, Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinnatifida and Areca catechu are mixed and first heated by microwave, and then crushed and sieved through 80 mesh in sequence to obtain mixed powder, which is used for subsequent decoction.

[0085] In this embodiment, the Chinese medicinal materials are first subjected to microwave heating and then crushed to obtain powdered Chinese medicinal materials for subsequent decoction, thereby improving the water extraction efficiency.

[0086] The pilot test of this embodiment is in accordance with the reference embodiment, and all indicators meet the requirements.

[0087] Embodiment 3:

[0088] This embodiment is based on Embodiment 2, and differs from Embodiment 2 in that: the time of each water extraction is shortened to 45 minutes.

[0089] The pilot test of this embodiment is in accordance with the reference embodiment, and all indicators meet the requirements.

[0090] Embodiment 4:

[0091] This embodiment is based on Embodiment 2, and differs from Embodiment 2 in that:

[0092] When preparing filtrate A and filtrate B, the water extraction tanks used have different structures, mainly because the stirring mechanism has been improved, such as Figure 1-Figure 3 As shown: the water extraction tank used in this embodiment includes a detachably connected tank body 1 and a tank cover 2, and a stirring mechanism;

[0093] The tank body 1 is provided with an interlayer 3, the bottom of the interlayer 3 is provided with an electric heating wire 11, and the bottom shape of the tank body 1 is hemispherical;

[0094] The stirring mechanism includes a motor 4, a vertical rotating shaft 5, a bevel gear 6, an arc-shaped disturbance plate 7, a connecting rod 8, a mounting seat 9 and a horizontal rotating shaft 10;

[0095] The motor 4 is installed on the top of the tank cover 2, one end of the vertical shaft 5 passes through the tank cover 2 and is connected to the power output shaft of the motor 4, and the other end is placed in the tank body 1; the bevel gear 6 is arranged on the vertical shaft 5; one end of the horizontal shaft 10 is rotatably connected to the vertical shaft 5, and the horizontal shaft 10 is vertically arranged with the vertical shaft 5, and the mounting seat 9 is installed on the horizontal shaft 10, and the mounting seat 9 is provided with a gear meshing with the bevel gear 6; the arc disturbance plate 7 is connected to the horizontal shaft 10 through the connecting rod 8, specifically, the mounting seat 9 is connected to the horizontal shaft 10 through the fixing bolt 13, and a sealing ring is arranged between the mounting seat 9 and the horizontal shaft 10, when the arc disturbance plate 7 rotates to the bottom of the tank body 1, the arc disturbance plate 7 can scrape the medicinal materials at the bottom of the tank body 1, specifically, the arc disturbance plate 7 includes an arc plate 71 and a vertical plate 72; the shape of the arc plate 71 matches the bottom shape of the tank body 1, and the vertical plate 72 is arranged at the rear end of the top of the arc plate 71.

[0096] In this embodiment, a rotating shaft 12 is provided on the outer wall of the tank body 1. When boiling is completed, the tank cover 2 and the stirring mechanism can be removed, and the tank body 1 can be rotated by the external rotating mechanism to pour the material in the tank body 1 out from the opening.

[0097] In this embodiment, an annular groove 51 is provided at the lower part of the vertical rotating shaft 5 near the bottom of the tank body 1, and the bottom of the annular groove 51 forms a sliding rod with a diameter smaller than the diameter of the vertical rotating shaft 5. A sliding disk 52 is sleeved on the sliding rod, and there is a gap between the sliding disk 52 and the sliding rod, and the axial thickness of the sliding disk 52 is smaller than the axial length of the sliding rod.

[0098] The pilot test of this embodiment is in accordance with the reference embodiment, and all indicators meet the requirements.

[0099] Embodiment 5:

[0100] This embodiment is based on embodiment 4, and differs from embodiment 4 in that the time of each water extraction is shortened to 45 minutes.

[0101] The pilot test of this embodiment is in accordance with the reference embodiment, and all indicators meet the requirements.

[0102] Comparative Example 1:

[0103] This comparative example is based on Example 1, and the difference from Example 1 is:

[0104] The preparation process of the Xiaoji Zhike honey paste is different. This comparative example adopts the one-pot boiling in the prior art and extracts under boiling state, which specifically includes the following steps:

[0105] Step A, put Sichuan Fritillaria, dried tangerine peel, platycodon, schisandra chinensis, radish seeds, pinellia tuber, polygala tenuifolia, ephedra, hawthorn and betel nut into a water extraction tank, add 8 times the amount of water based on the total weight of the Chinese medicinal materials, heat to boiling, and boil for 60 minutes in a boiling state; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, and boil for 60 minutes in a boiling state; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, and boil for 60 minutes in a boiling state; filter to obtain a third filtrate, filtrate;

[0106] Step B, concentrating the filtrate obtained in step A to a relative density of 1.30 (70° C.), standing and cooling, to obtain a concentrated solution;

[0107] Step C: add licorice extract and menthol to the concentrated solution obtained in step B, stir and mix thoroughly, add honey to 10L, mix evenly, and adjust the pH value to 6.0 with NaOH to obtain a honey paste for eliminating accumulation and relieving cough.

[0108] Comparative Example 2:

[0109] This comparative example is based on Example 1, and the difference from Example 1 is that during decoction, the amount of water added is different, the decoction process is different each time, and 6 times the amount of water is added for decoction each time.

[0110] Comparative Example 3:

[0111] This comparative example is based on Example 1, and the difference from Example 1 is that during decoction, the amount of water added is different, the decoction process is different each time, and 10 times the amount of water is added for decoction each time.

[0112] Comparative Example 4:

[0113] This comparative example is based on Example 1, and the difference from Example 1 is that the decoction time is different, and each decoction time is 90 minutes.

[0114] Comparative Example 5:

[0115] This comparative example is based on Example 1, and the difference from Example 1 is that the decoction time is different, and each decoction time is 30 minutes.

[0116] Comparative Example 6:

[0117] The comparative example is based on Example 1, and the difference from Example 1 is that:

[0118] The preparation process of the honey paste for eliminating accumulation and relieving cough is different. This comparative example refers to the preparation method disclosed in the authorized patent CN112841573B. All the Chinese medicinal materials in the prescription are boiled in one pot and extracted twice. Each time the water is added to 3 times the amount of the Chinese medicinal materials, and boiled for 0.5 hours under a slightly boiling state.

[0119] Put Fritillaria cirrhosa, dried orange peel, Platycodon grandiflorum, Schisandra chinensis, Radish seeds, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinellia and Areca catechu into a water extraction tank, add 3 times the amount of water based on the total weight of the Chinese medicinal materials, heat to boiling, and then decoct for 30 minutes in a slightly boiling state; filter to obtain a first filtrate; add 3 times the amount of water to the filter residue again, heat to boiling, and then decoct for 30 minutes in a slightly boiling state; filter to obtain a second filtrate; combine the first filtrate and the second filtrate to obtain a filtrate;

[0120] Step B, concentrating the filtrate obtained in step A to a relative density of 1.30 (70° C.), standing and cooling, to obtain a concentrated solution;

[0121] Step C: add licorice extract and menthol to the concentrated solution obtained in step B, stir and mix thoroughly, add honey to 10L, mix evenly, and adjust the pH value to 6.0 with NaOH to obtain a honey paste for eliminating accumulation and relieving cough.

[0122] Liquid chromatography was used to test the hesperidin content (mg / bottle) of the Xiaoji Zhike Mi Lian Gao prepared in Examples 1 to 5 and Comparative Examples 1 to 6. The hesperidin content obtained in each Example and Comparative Example was obtained by randomly selecting three bottles from three batches of samples, and the average of the nine bottles was taken. The results are shown in Table 3:

[0123] Table 3

[0124]

[0125] Note: Since dried tangerine peel is the main drug in the prescription of the present invention, and hesperidin, the effective ingredient of dried tangerine peel, is greatly affected by temperature, the content of hesperidin is used as the test result to determine the effective ingredient of the prepared Xiaoji Zhike Mi Lian Gao.

[0126] From the data in Table 3, we can see that:

[0127] 1) From the data comparison of Comparative Example 1, Comparative Example 6 and Example 1, it can be seen that:

[0128] The extraction temperature has a great influence on the hesperidin content in the Xiaoji Zhike Mi Lian ointment of the above prescription. By adopting the separate pot decocting of the present invention, and water extraction of Fritillaria cirrhosa and dried orange peel at 70-75°C; water extraction of Platycodon grandiflorum, Schisandra chinensis, Radish Seed, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinellia and Areca catechu at 80-85°C, the hesperidin content in the product can be increased.

[0129] 2) From the data of Example 1 to Example 5, it can be seen that:

[0130] Although the extraction efficiency can be improved by increasing the contact area with water by using powdered Chinese medicinal materials for water extraction, the hesperidin content in Example 2 is lower than that in Example 1. After the extraction time is shortened in Example 2, the hesperidin content is higher than that in Example 2. The reason for this may be that the water extraction tank used in Examples 1 to 3 causes the powdered Chinese medicinal materials to be deposited at the bottom of the tank, resulting in a high heating temperature for the Chinese medicinal materials in this part, and the high temperature causes the decomposition and loss of hesperidin. Therefore, in Examples 4 and 5, the problem of the powdered Chinese medicinal materials being deposited at the bottom of the tank can be avoided by powdering the Chinese medicinal materials and improving the water tank. As a result, compared with Example 1, the hesperidin content is increased. When the extraction time is shortened from 60 min to 45 min, the hesperidin content is not significantly reduced, indicating that the use of powdered Chinese medicinal materials in combination with the water extraction tank in Example 4 can improve the water extraction efficiency and shorten the water extraction time.

[0131] 3) From the data of Example 1 and Comparative Examples 2 to 5, it can be seen that:

[0132] Each time the decoction is performed, the amount of water added and the decoction time will affect the hesperidin content.

[0133] Liquid chromatography testing of hesperidin content is an existing technology, and the specific process is as follows:

[0134] Content determination: (Keep away from light) Determine by referring to high performance liquid chromatography.

[0135] Chromatographic conditions and system suitability test: Chromatographic column: Agilent Eclipse XDB-C18 (4.6×150mm, 5µm); mobile phase: acetonitrile-0.1% phosphoric acid (17:83); flow rate: 1ml / min; detection wavelength: 283nm; column temperature: 30℃. The theoretical plate number calculated based on the hesperidin peak should be no less than 3000.

[0136] Preparation of reference solution: Take an appropriate amount of hesperidin reference substance, weigh accurately, and add methanol to make a solution containing 0.16 mg per 1 ml.

[0137] Preparation of test solution: Take about 2.5 g of the product (i.e., the Xiaoji Zhike Honey Refined Paste prepared in each embodiment and comparative example), accurately weigh, place in a stoppered conical flask, accurately add 25 ml of methanol, seal, weigh, heat under reflux for extraction for 1 hour, cool, weigh again, make up the lost weight with methanol, shake well, filter, and take the filtrate to obtain.

[0138] Determination method: Accurately pipette 10µl of reference solution and test solution respectively, inject into liquid chromatograph, and determine.

[0139] Note: Each 1g of this product should contain no less than 0.3mg of hesperidin.

[0140] The above specific implementation methods further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above are only specific implementation methods of the present invention and are not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

[0141] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the present invention, so they have no substantial technical significance. Any modification of the structure, change of the proportional relationship or adjustment of the size should still fall within the scope of the technical content disclosed by the present invention without affecting the effects and purposes that can be achieved by the present invention. At the same time, the terms such as "upper", "lower", "left", "right", "middle" and the like cited in this specification are only for the convenience of description, and are not used to limit the scope of the implementation of the present invention. The change or adjustment of the relative relationship should also be regarded as the scope of the implementation of the present invention without substantially changing the technical content.

Claims

1. A method for preparing a honey paste for eliminating phlegm and relieving cough, characterized in that: The prescription of the honey-refined paste for eliminating stagnation and relieving cough is: Fritillaria 45g, dried orange peel 168g, Platycodon grandiflorum 168g, Schisandra 95g, Radish seed 77g, Pinellia 77g, Polygala 95g, Ephedra 38g, Hawthorn 77g, Areca 77g, Licorice extract 27g, Menthol 4.4g, Honey; The preparation method comprises the following steps: S1, Fritillaria cirrhosa and dried orange peel were extracted with water at 70-75°C to obtain filtrate A; Platycodon grandiflorum, Schisandra chinensis, Radish seeds, Pinellia ternata, Polygala tenuifolia, Ephedra sinica, Crataegus pinellia and Areca catechu were extracted with water at 80-85°C to obtain filtrate B; The water extraction process is to add 8 times the amount of water and boil for 3 times, and each boiling time is 45-60 minutes; S2, after evenly mixing filtrate A and filtrate B, concentrating and cooling to obtain a concentrated solution; S3, adding liquorice extract, menthol and honey to the concentrated solution obtained in step S2, mixing evenly, and adjusting the pH value to 4.5-7.5 to obtain a honey-refined paste for eliminating accumulation and relieving cough; When preparing filtrate A and filtrate B, a water extraction tank is used for decoction, wherein the water extraction tank comprises a detachably connected tank body (1) and a tank cover (2), and a stirring mechanism; When preparing filtrate A, the fritillaria chuanxiong and tangerine peel are first pretreated: the fritillaria chuanxiong and tangerine peel are mixed and first heated by microwave, and then crushed and sieved through 60-80 meshes in sequence to obtain fritillaria chuanxiong and tangerine peel powder, which is used for subsequent decoction; The tank body (1) is provided with an interlayer (3), an electric heating wire (11) is provided at the bottom of the interlayer (3), and the bottom shape of the tank body (1) is hemispherical; The stirring mechanism comprises a motor (4), a vertical rotating shaft (5), a bevel gear (6), an arc-shaped disturbance plate (7), a connecting rod (8), a mounting seat (9) and a horizontal rotating shaft (10); The motor (4) is mounted on the top of the tank cover (2); one end of the vertical rotating shaft (5) passes through the tank cover (2) and is connected to the power output shaft of the motor (4); the other end is placed in the tank body (1); the bevel gear (6) is arranged on the vertical rotating shaft (5); one end of the horizontal rotating shaft (10) is rotatably connected to the vertical rotating shaft (5), and the horizontal rotating shaft (10) is arranged perpendicular to the vertical rotating shaft (5); the mounting seat (9) is mounted on the horizontal rotating shaft (10), and a gear meshing with the bevel gear (6) is arranged on the mounting seat (9); the arc-shaped disturbance plate (7) is connected to the horizontal rotating shaft (10) through the connecting rod (8); when the arc-shaped disturbance plate (7) rotates to the bottom of the tank body (1), the arc-shaped disturbance plate (7) can scrape the medicinal materials at the bottom of the tank body (1).

2. The preparation method according to claim 1, characterized in that: In step S1, the preparation process of filtrate A is as follows: Put the Fritillaria citrus peel powder into an extraction tank, add 8 times the amount of water based on the total weight of the Fritillaria citrus peel powder, heat to boiling, then cool to 70-75°C, and boil for 45-60 minutes; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 70-75°C, and boil for 45-60 minutes; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 70-75°C, and boil for 45-60 minutes; filter to obtain a third filtrate, and evenly mix the first filtrate, the second filtrate and the third filtrate to obtain filtrate A.

3. The preparation method according to claim 1, characterized in that: In step S1, the preparation process of filtrate B is: Put platycodon, schisandra, radish seeds, pinellia, polygala, ephedra, hawthorn and areca into an extraction tank; add 8 times the amount of water according to the total weight of platycodon, schisandra, radish seeds, pinellia, polygala, ephedra, hawthorn and areca, heat to boiling, then cool to 80-85°C, and boil for 45-60 minutes; filter to obtain a first filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 80-85°C, and boil for 45-60 minutes; filter to obtain a second filtrate; add 8 times the amount of water to the filter residue again, heat to boiling, then cool to 80-85°C, and boil for 45-60 minutes; filter to obtain a third filtrate, and mix the first filtrate, the second filtrate and the third filtrate evenly to obtain filtrate B.

4. The preparation method according to claim 3, characterized in that: Platycodon grandiflorum, schisandra chinensis, radish seeds, pinellia ternata, polygala tenuifolia, ephedra, hawthorn and areca catechu are mixed and first heated in a microwave, and then crushed and sieved through 60-80 meshes in sequence to obtain a mixed powder, which is used for subsequent decoction.

5. The preparation method according to claim 1, characterized in that: In step S3, the pH value is adjusted to 6.

0.

6. The preparation method according to claim 1, characterized in that: The arc-shaped disturbance plate (7) comprises an arc-shaped plate (71) and a vertical plate (72); the shape of the arc-shaped plate (71) matches the bottom shape of the tank body (1), and the vertical plate (72) is arranged at the top rear end of the arc-shaped plate (71).

7. The preparation method according to claim 1, characterized in that: An annular groove (51) is provided at the lower part of the vertical rotating shaft (5) near the bottom of the tank body (1); a sliding rod having a diameter smaller than that of the vertical rotating shaft (5) is formed at the bottom of the annular groove (51); a sliding plate (52) is sleeved on the sliding rod, and a gap is provided between the sliding plate (52) and the sliding rod; and an axial thickness of the sliding plate (52) is smaller than an axial length of the sliding rod.

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