A medicine for treating osteoporosis and a preparation method thereof

Abstract

This invention relates to the field of traditional Chinese medicine technology, and in particular to a drug for treating osteoporosis and its preparation method. By weight, the raw materials of the drug for treating osteoporosis include: 2-5 parts of Gastrodia elata, 4-10 parts of Cistanche deserticola, 3-8 parts of Epimedium brevicornu, 2.5-6.5 parts of Akebia trifoliata, 3-7 parts of Rehmannia glutinosa, 2-4.5 parts of Lycium barbarum, 5-15 parts of Angelica sinensis, 8-20 parts of Panax notoginseng, 4-12 parts of Ligusticum chuanxiong, 3-7 parts of Cinnamomum cassia, 2-5 parts of Achyranthes bidentata, 2.5-5 parts of donkey-hide gelatin, 2-4 parts of oyster shell, 0.5-1.5 parts of sesame, 0.1-0.3 parts of pig liver, and 1-2.5 parts of fish roe. The drug for treating osteoporosis provided in this application has a high content of calcium, phosphorus, and vitamin D, which helps promote calcium absorption and utilization. The raw materials synergistically regulate bone metabolism, inhibit bone resorption, promote bone formation, and thus increase bone density, with rapid efficacy.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a drug for treating osteoporosis and its preparation method. Background Technology

[0002] Osteoporosis is a major disease threatening human health. It is characterized by reduced bone mass, decreased bone density, and weakened bone strength. Clinically, it mainly manifests as localized pain, deformity, and fractures.

[0003] Currently, there are many Western medicine drugs for treating osteoporosis. While these drugs are effective to some extent, their efficacy diminishes with prolonged treatment, and concerns about drug safety and adverse reactions are growing. For example, anti-osteoporosis chemical drugs are mainly divided into drugs that inhibit bone resorption and drugs that promote bone formation, such as estrogen, calcitonin, parathyroid hormone, bisphosphonates, and calcium supplements. However, excessive calcium supplementation can increase the incidence of cardiovascular disease and kidney stones, calcitonin use can increase the incidence of cancer, and hormone replacement therapy carries the potential risks of stroke and venous thrombosis.

[0004] With the vigorous development of traditional Chinese medicine (TCM), it plays an increasingly important role in the treatment of osteoporosis. TCM treatment for osteoporosis largely focuses on tonifying the kidneys and strengthening bones, warming and tonifying kidney yang, nourishing the liver and kidneys, and promoting blood circulation and removing blood stasis. However, the effects of current TCM treatments for osteoporosis are slow, and the bitter taste of these herbs makes it difficult for many patients with mild osteoporosis to adhere to the prescribed medication regimen, resulting in unsatisfactory treatment outcomes. Summary of the Invention

[0005] In order to accelerate the efficacy of traditional Chinese medicine in treating osteoporosis, this application provides a drug for treating osteoporosis and a method for preparing the same.

[0006] In a first aspect, this application provides a drug for treating osteoporosis, implemented using the following technical solution:

[0007] A medicine for treating osteoporosis, comprising, by weight, the following ingredients: 2-5 parts Gastrodia elata, 4-10 parts Cistanche deserticola, 3-8 parts Epimedium brevicornu, 2.5-6.5 parts Akebia trifoliata, 3-7 parts Rehmannia glutinosa, 2-4.5 parts Lycium barbarum, 5-15 parts Angelica sinensis, 8-20 parts Panax notoginseng, 4-12 parts Ligusticum chuanxiong, 3-7 parts Cinnamomum cassia, 2-5 parts Achyranthes bidentata, 2.5-5 parts donkey-hide gelatin, 2-4 parts oyster shell, 0.5-1.5 parts sesame seeds, 0.1-0.3 parts pig liver, and 1-2.5 parts fish roe.

[0008] Panax notoginseng and Ligusticum chuanxiong help improve local blood circulation, promote nutrient supply to bone tissue, and reduce the occurrence of osteoporosis. Cistanche deserticola and Epimedium strengthen bones and muscles, invigorate yang and tonify the kidneys, thereby enhancing bone structure and function. Angelica sinensis has the effects of promoting blood circulation, removing blood stasis, and nourishing blood and qi. It has a certain auxiliary effect on poor blood circulation or insufficient qi and blood in bones caused by osteoporosis, and helps promote the proliferation and differentiation of bone marrow mesenchymal stem cells, thus contributing to bone regeneration. Akebia trifoliata and Rehmannia glutinosa can regulate the activity of osteocytes and promote the function of bone morphocytes, thereby enhancing bone density and strength. Rehmannia glutinosa and Lycium barbarum can tonify kidney qi and enhance the essential physiological function of bones, thereby slowing the progression of osteoporosis. Rehmannia glutinosa helps clear heat and detoxify, remove dampness and relieve pain, and improve the body's internal environment. It can alleviate the heat-related reactions caused by Lycium barbarum, Panax notoginseng, Ligusticum chuanxiong, Cistanche deserticola, Epimedium, and Angelica sinensis, which is beneficial for the treatment and prevention of osteoporosis. Gastrodia elata has the effects of calming the liver and suppressing yang, dispelling wind and relieving spasms, and helps regulate the nervous system, which may affect the activity of bone marrow mesenchymal stem cells. Cinnamomum cassia has the effects of warming yang and promoting blood circulation, dispelling wind and cold, and helps improve microcirculation, increase the nutritional supply to bone tissue, and indirectly promote the synthesis of bone matrix proteins. Achyranthes bidentata has the effects of promoting blood circulation and removing blood stasis, and strengthening tendons and bones. It is believed to be able to promote bone metabolism and improve the ability to synthesize bone matrix proteins. Rehmannia glutinosa, Lycium barbarum, Panax notoginseng, Ligusticum chuanxiong, Cistanche deserticola, Epimedium brevicornu, Angelica sinensis, Gastrodia elata, Cinnamomum cassia and Achyranthes bidentata have a synergistic effect. Through different pharmacological mechanisms or pathways of action, they can work together to regulate bone metabolism, inhibit bone resorption, promote bone formation, and thus increase bone density, significantly enhancing the therapeutic effect.

[0009] During the research process, the inventors discovered that Rehmannia glutinosa, Cinnamomum cassia, Ligusticum chuanxiong, Achyranthes bidentata, and Colla corii asini have a synergistic effect, which can significantly improve the ability of bone matrix protein synthesis, thereby accelerating the efficacy of traditional Chinese medicine in the treatment of osteoporosis and improving the treatment effect.

[0010] During their research, the inventors unexpectedly discovered that oysters and sesame seeds contain high levels of calcium and phosphorus, which helps strengthen bones. Furthermore, the abundant unsaturated fatty acids in sesame seeds help reduce the fishy and ammonia-like odor of oysters. Pork liver and fish roe contain vitamin D, which can increase the vitamin D content in medications used to treat osteoporosis. The fish oil in fish roe can promote the dissolution and release of vitamin D from pork liver, while also improving its stability, thus promoting calcium absorption and utilization, thereby accelerating the efficacy of traditional Chinese medicine for treating osteoporosis. The proteins in sesame seeds and fish roe, together with donkey-hide gelatin, help support the stability and elasticity of bone structure, maintaining bone health.

[0011] Preferably, by weight, the raw materials of the drug for treating osteoporosis include: 3-4 parts of Gastrodia elata, 6-8 parts of Cistanche deserticola, 4-6 parts of Epimedium brevicornu, 4-5 parts of Akebia trifoliata, 3.5-5.5 parts of Rehmannia glutinosa, 3-4 parts of Lycium barbarum, 8-12 parts of Angelica sinensis, 12-15 parts of Panax notoginseng, 7-9 parts of Ligusticum chuanxiong, 4-5 parts of Cinnamomum cassia, 3-4 parts of Achyranthes bidentata, 3.5-4.5 parts of donkey-hide gelatin, 3-4 parts of oyster shell, 1-1.5 parts of sesame, 0.1-0.2 parts of pig liver, and 2-2.5 parts of fish roe.

[0012] More preferably, by weight, the raw materials of the medicine for treating osteoporosis include: 3.5 parts of Gastrodia elata, 7 parts of Cistanche deserticola, 5 parts of Epimedium brevicornu, 4.5 parts of Akebia trifoliata, 4.5 parts of Rehmannia glutinosa, 3.5 parts of Lycium barbarum, 10 parts of Angelica sinensis, 14 parts of Panax notoginseng, 8 parts of Ligusticum chuanxiong, 4.5 parts of Cinnamomum cassia, 3.5 parts of Achyranthes bidentata, 4 parts of donkey-hide gelatin, 3.5 parts of oyster shell, 1.5 parts of sesame, 0.1 parts of pig liver, and 2.5 parts of fish roe.

[0013] Preferably, the raw materials of the medicament for treating osteoporosis also include pharmaceutically acceptable excipients.

[0014] Excipients improve the taste of medications used to treat osteoporosis and increase patient tolerance.

[0015] In this application, the excipients are selected from at least one of mannitol, lactose, starch, dextrin, glucose, and sucrose.

[0016] Preferably, the drug for treating osteoporosis is an oral preparation; the dosage form of the drug for treating osteoporosis is selected from at least one of capsules, tablets, and granules.

[0017] More preferably, the dosage form of the drug for treating osteoporosis is granules.

[0018] Secondly, this application provides a method for preparing a drug for treating osteoporosis, employing the following technical solution:

[0019] A method for preparing a drug for treating osteoporosis includes the following steps:

[0020] (1) Grind Gastrodia elata, Cistanche deserticola, Epimedium brevicornu, Akebia trifoliata, Rehmannia glutinosa, Lycium barbarum, Angelica sinensis, Panax notoginseng, Ligusticum chuanxiong, Cinnamomum cassia and Achyranthes bidentata, sieve and extract with water, filter, concentrate and dry to obtain water extract dry powder.

[0021] (2) Grind the oysters and sesame seeds, sieve them, extract them with edible vinegar, filter, concentrate and dry them to obtain edible vinegar extract powder.

[0022] (3) Grind the pig liver and fish roe, sieve them, extract them with vegetable oil, filter, concentrate and dry them to obtain vegetable oil extract powder.

[0023] (4) Mix the donkey-hide gelatin, the edible vinegar extract powder obtained in step (2) and the vegetable oil extract powder obtained in step (3) evenly, then add the water extract powder obtained in step (1) and mix evenly to obtain a mixed dry powder.

[0024] (5) Add excipients to the mixed dry powder obtained in step (4), stir evenly, granulate, and dry to obtain a drug for treating osteoporosis.

[0025] The preparation method provided by this invention is simple, suitable for large-scale industrial production and application, can ensure the extraction of effective components, can significantly improve the cure rate of osteoporosis caused by calcium deficiency, and has a fast effect and few toxic side effects.

[0026] Preferably, the mass ratio of oysters to sesame seeds is 3.5:1.5.

[0027] Preferably, the ratio of material to liquid in the vinegar extraction is 1:(6-8); the extraction temperature is 90-110℃; and the extraction time is 3-5 hours.

[0028] Preferably, the mass ratio of the pig liver to the fish roe is 0.1:2.5.

[0029] Pork liver contains a certain amount of vitamin D, which can improve calcium absorption and utilization. However, pork liver is rich in vitamin A and iron. Excessive intake of vitamin A increases the risk of osteoporosis, while excessive iron intake may affect calcium absorption and utilization, indirectly impacting bone health. By controlling the mass ratio of pork liver to fish roe, vitamin D can be better extracted, thereby increasing the vitamin D content and stability in medications used to treat osteoporosis. Fish oil in fish roe can reduce vitamin A extraction and promote calcium absorption and utilization, thus accelerating the efficacy of traditional Chinese medicine for treating osteoporosis.

[0030] Preferably, the vegetable oil is a mixture of walnut oil and avocado oil in a mass ratio of 1:(0.8-1.2).

[0031] Avocado oil contains monounsaturated fatty acids, and walnut oil is rich in alpha-linolenic acid. The blend of walnut oil and avocado oil has better compatibility with vitamin D, which helps to enhance the solubility and stability of vitamin D, while reducing the precipitation of vitamin A in pork liver. This can further promote the absorption and utilization of calcium, thereby accelerating the efficacy of traditional Chinese medicine in the treatment of osteoporosis.

[0032] Preferably, the ratio of the material to the liquid in the vegetable oil extraction is 1:(8-10).

[0033] In summary, this application has the following beneficial effects:

[0034] 1. Rehmannia glutinosa, Lycium barbarum, Panax notoginseng, Ligusticum chuanxiong, Cistanche deserticola, Epimedium brevicornu, Angelica sinensis, Gastrodia elata, Cinnamomum cassia, and Achyranthes bidentata exhibit synergistic effects. Through different pharmacological mechanisms or pathways of action, they work together to significantly enhance therapeutic efficacy. Rehmannia glutinosa, Cinnamomum cassia, Ligusticum chuanxiong, Achyranthes bidentata, and Colla corii asini also have synergistic effects, significantly improving the synthesis of bone matrix proteins, thereby accelerating the efficacy of traditional Chinese medicine in treating osteoporosis and improving therapeutic results.

[0035] 2. Oysters and sesame seeds are high in calcium and phosphorus, which helps strengthen bones. The abundant unsaturated fatty acids in sesame seeds also help reduce the fishy and ammonia-like smell of oysters. Pork liver and fish roe contain vitamin D, which can increase the vitamin D content in medications used to treat osteoporosis. The fish oil in fish roe can promote the dissolution and release of vitamin D from pork liver, while also improving its stability, which helps promote calcium absorption and utilization, thereby accelerating the efficacy of traditional Chinese medicine for treating osteoporosis.

[0036] 3. The vegetable oil, a blend of walnut oil and avocado oil, has better compatibility with vitamin D, which helps to enhance the solubility and stability of vitamin D, while reducing the precipitation of vitamin A in pork liver. This can further promote the absorption and utilization of calcium, thereby accelerating the efficacy of traditional Chinese medicine in the treatment of osteoporosis. Detailed Implementation

[0037] The present application will be further described in detail below with reference to the embodiments.

[0038] Example

[0039] Examples 1-9 provide a drug for treating osteoporosis. The following description uses Example 1 as an example.

[0040] The preparation steps of the drug for treating osteoporosis provided in Example 1 are as follows:

[0041] (1) Mix 200g Gastrodia elata, 400g Cistanche deserticola, 300g Epimedium brevicornu, 250g Akebia trifoliata, 300g Rehmannia glutinosa, 200g Lycium barbarum, 500g Angelica sinensis, 800g Panax notoginseng, 400g Ligusticum chuanxiong, 300g Cinnamomum cassia and 200g Achyranthes bidentata evenly, grind until the particle size is less than 40 mesh, pass through a 40 mesh sieve, take the raw material particles with a particle size less than 40 mesh, add 10 times the mass of water to the raw material particles, soak at 30℃ for 2 hours, decoct for 5 hours, filter, and obtain the first filtrate and the filter residue; add 5 times the mass of water to the filter residue, decoct for 4 hours, filter, and obtain the second filtrate, combine the first filtrate and the second filtrate, concentrate and dry to obtain the water extract dry powder;

[0042] (2) Mix 200g of oysters and 50g of sesame seeds evenly, grind them until the particle size is less than 100 mesh, pass them through a 100 mesh sieve, take the raw material particles with a particle size less than 100 mesh, add 6 times the mass of edible vinegar (acetic acid content is 5wt%) to the raw material particles, heat to 100℃, heat at 100℃ for 4h, filter, obtain filtrate, concentrate and dry to obtain edible vinegar extract dry powder;

[0043] (3) Mix 10g of pork liver and 100g of fish roe evenly, grind them until the particle size is less than 100 mesh, pass them through a 100 mesh sieve, take the raw material particles with a particle size less than 100 mesh, add 8 times the mass of walnut oil to the raw material particles, heat to 60℃, heat at 60℃ for 8 hours, filter, obtain filtrate, concentrate and dry to obtain vegetable oil extract dry powder.

[0044] (4) Mix 250g of donkey-hide gelatin, the edible vinegar extract powder obtained in step (2) and the vegetable oil extract powder obtained in step (3) evenly, then add the water extract powder obtained in step (1) and mix evenly to obtain a mixed dry powder.

[0045] (5) Add dextrin and sucrose to the mixed dry powder obtained in step (4), stir evenly, granulate, and dry to obtain a drug for treating osteoporosis; the mass ratio of the mixed dry powder, dextrin and sucrose obtained in step (4) is 10:3.5:1.

[0046] The drugs for treating osteoporosis provided in Examples 2-6 differ from those in Example 1 only in the quality of the raw materials used in the drugs for treating osteoporosis, as detailed in Table 1.

[0047] Table 1. Mass / g of raw materials for the drugs used in the treatment of osteoporosis in Examples 1-6.

[0048]

[0049]

[0050] The drug for treating osteoporosis provided in Example 7 differs from that in Example 6 only in that walnut oil is replaced with avocado oil.

[0051] The drug for treating osteoporosis provided in Example 8 differs from that in Example 6 only in that the mass of walnut oil is replaced with a mixture of walnut oil and avocado oil, with a mass ratio of walnut oil to avocado oil of 1:0.8.

[0052] The only difference between the medicine for treating osteoporosis provided in Example 9 and that in Example 8 is that the mass ratio of walnut oil to avocado oil is 1:1.

[0053] Comparative Example

[0054] The drug for treating osteoporosis provided in Comparative Example 1 differs from that in Example 1 only in that the amount of sesame seeds is replaced with oyster shells.

[0055] The drug for treating osteoporosis provided in Comparative Example 2 differs from that in Example 1 only in that the oyster shell is replaced with sesame seeds.

[0056] The drug for treating osteoporosis provided in Comparative Example 3 differs from that in Example 1 only in that the mass of pig liver is replaced with fish roe.

[0057] The drug for treating osteoporosis provided in Comparative Example 4 differs from that in Example 1 only in that the mass of fish roe is replaced with pig liver.

[0058] Performance testing

[0059] The following therapeutic efficacy tests were conducted on the drugs for treating osteoporosis provided in Examples 1-9 and Comparative Examples 1-4 of this application.

[0060] 1. Experimental animals: 150 male Wistar rats weighing 180-220g and aged 8-10 weeks (purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd.) were selected. After one week of acclimatization, the 150 male Wistar rats were randomly divided into 15 groups of 10 rats each. These groups were named blank control group (normal rats), model group (no treatment), treatment groups 1-9, and control treatment groups 1-4.

[0061] 2. Model Establishment: Except for the blank control group (normal rats), rats in the blank control group were injected intramuscularly with physiological saline. Rats in the model group (no treatment), treatment groups 1-9, and control treatment groups 1-4 were injected intramuscularly with dexamethasone to serve as experimental animal models of glucocorticoid-induced osteoporosis. The dosage of physiological saline and dexamethasone was 2.5 mg / kg each time. －1 Weigh yourself twice a week for eight weeks.

[0062] 3. Administration method: While establishing the model, rats in both the blank control group and the model group were continuously administered 10 mL / kg of distilled water by gavage. -1 Rats in treatment groups 1-9 and control groups 1-4 were continuously administered 10 mL / kg of the drug solution (prepared by adding distilled water to the drugs for treating osteoporosis prepared in Examples 1-9 and Comparative Examples 1-4 to prepare a 0.04 g / mL solution). -1 Administer once daily via gavage for 4 or 12 consecutive weeks.

[0063] 4. Detection indicators: Check and record the bone mineral density and bone calcium content of rats before treatment and after 4 and 12 weeks of treatment.

[0064] After sacrificing the rats, femoral tissue was collected, and surrounding soft tissue and cartilage were removed. The bone mineral density of the femur in each group of rats was detected by dual-energy X-ray absorptiometry. The test results are shown in Table 2.

[0065] The amount of calcium in femoral bone ash was determined by EDTA titration to represent the bone calcium content of the femur: 0.1 g of femoral bone ash was accurately weighed into an Erlenmeyer flask, 1 mL of 12 mol / L hydrochloric acid was added, and after dissolution, 10 mL of pure water was added; diethylamine was added to adjust the pH to neutral, then 2 drops of 10 g / L KCN aqueous solution and 4 drops of 0.05 mol / L sodium citrate aqueous solution were added; after shaking well, diethylamine was added to adjust the pH to 12-13, and then 4 drops of sodium calcium carboxylate indicator (purchased from Aladdin) were added. The solution was titrated with 0.01 mol / L EDTA standard solution until the solution changed from pink to pure blue, which was the endpoint; the calcium content in the femoral bone ash, i.e., the bone calcium content, was calculated based on the volume consumed. The test results are shown in Table 2.

[0066] 5. Data Processing: Data from each group were expressed as mean plus or minus standard deviation. Significant differences between groups were assessed using a one-way ANOVA t-test with SPSS statistical software. A p-value < 0.05 was considered statistically significant.

[0067] Table 2 Treatment efficacy data

[0068]

[0069]

[0070] Note: Compared with the group before treatment, P < 0.05.

[0071] The following section details this application based on the test data in Table 2.

[0072] The bone mineral density (BMD) and bone calcium content in the blank control group were higher than those in the model group before treatment, at 4 weeks, and at 12 weeks, indicating that osteoporosis reduces BMD and bone calcium content. Compared to the model group, the treatment groups 1-9 showed significant increases in BMD and bone calcium content at 4 weeks and 12 weeks, indicating that treatment groups 1-9 effectively increase BMD and bone calcium. This demonstrates that the drug for treating osteoporosis provided in this application has high calcium, phosphorus, and vitamin D content, which helps promote calcium absorption and utilization. Furthermore, the raw materials used in its preparation synergistically regulate bone metabolism, inhibit bone resorption, promote bone formation, and thus increase bone mineral density.

[0073] Compared with the control group 1-4, the bone mineral density and bone calcium content of the treatment groups 1-9 after 4 weeks of treatment were higher than those of the control group 1-4. Moreover, the bone mineral density and bone calcium content of the treatment groups 1-9 after 4 weeks of treatment were closer to those of the blank control group. This indicates that oysters and sesame seeds contain high levels of calcium and phosphorus, which help strengthen bones. Pig liver and fish roe contain vitamin D, which can increase the content and stability of vitamin D, help promote calcium absorption and utilization, and thus accelerate the efficacy of traditional Chinese medicine in the treatment of osteoporosis.

[0074] Compared with treatment groups 6-7, treatment groups 8-9 showed bone mineral density and bone calcium content closer to the blank control group after 4 weeks of treatment. This indicates that the vegetable oil blended from walnut oil and avocado oil has better compatibility with vitamin D, which helps enhance vitamin D solubility and stability, while reducing the precipitation of vitamin A in pig liver. This can further promote calcium absorption and utilization, thereby accelerating the efficacy of traditional Chinese medicine in treating osteoporosis.

[0075] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A drug for treating osteoporosis, characterized in that, The ingredients of the medicine for treating osteoporosis, by weight, include: 2-5 parts of Gastrodia elata, 4-10 parts of Cistanche deserticola, 3-8 parts of Epimedium brevicornu, 2.5-6.5 parts of Akebia trifoliata, 3-7 parts of Rehmannia glutinosa, 2-4.5 parts of Lycium barbarum, 5-15 parts of Angelica sinensis, 8-20 parts of Panax notoginseng, 4-12 parts of Ligusticum chuanxiong, 3-7 parts of Cinnamomum cassia, 2-5 parts of Achyranthes bidentata, 2.5-5 parts of donkey-hide gelatin, 2-4 parts of oyster shell, 0.5-1.5 parts of sesame seeds, 0.1-0.3 parts of pig liver, and 1-2.5 parts of fish roe. The mass ratio of pork liver to fish roe is 0.1:2.5; the mass ratio of oyster to sesame is 3.5:1.

5.

2. The drug for treating osteoporosis according to claim 1, characterized in that, The ingredients of the medicine for treating osteoporosis, by weight, include: 3-4 parts of Gastrodia elata, 6-8 parts of Cistanche deserticola, 4-6 parts of Epimedium brevicornu, 4-5 parts of Akebia trifoliata, 3.5-5.5 parts of Rehmannia glutinosa, 3-4 parts of Lycium barbarum, 8-12 parts of Angelica sinensis, 12-15 parts of Panax notoginseng, 7-9 parts of Ligusticum chuanxiong, 4-5 parts of Cinnamomum cassia, 3-4 parts of Achyranthes bidentata, 3.5-4.5 parts of donkey-hide gelatin, 3-4 parts of oyster shell, 1-1.5 parts of sesame, 0.1-0.2 parts of pig liver, and 2-2.5 parts of fish roe.

3. A medicament for treating osteoporosis according to claim 1 or 2, characterized in that, The ingredients of the drug for treating osteoporosis also include pharmaceutically acceptable excipients.

4. The drug for treating osteoporosis according to claim 3, characterized in that, The drug for treating osteoporosis is an oral preparation; the dosage form of the drug for treating osteoporosis is selected from at least one of capsules, tablets, and granules.

5. A method for preparing a medicament for treating osteoporosis according to claim 4, characterized in that, Includes the following steps: (1) Grind the following ingredients: Gastrodia elata, Cistanche deserticola, Epimedium brevicornu, Akebia trifoliata, Rehmannia glutinosa, Lycium barbarum, Angelica sinensis, Panax notoginseng, Ligusticum chuanxiong, Cinnamomum cassia and Achyranthes bidentata. After sieving, extract with water, filter, concentrate and dry to obtain water-extracted dry powder. (2) Grind the oysters and sesame seeds, sieve them, extract them with edible vinegar, filter, concentrate and dry them to obtain edible vinegar extract powder; (3) Grind the pig liver and fish roe, sieve them, extract them with vegetable oil, filter, concentrate and dry them to obtain vegetable oil extract powder; (4) Mix the donkey-hide gelatin, the edible vinegar extract powder obtained in step (2) and the vegetable oil extract powder obtained in step (3) evenly, then add the water extract powder obtained in step (1) and mix evenly to obtain a mixed dry powder. (5) Add excipients to the mixed dry powder obtained in step (4), stir evenly, granulate, and dry to obtain a drug for treating osteoporosis.

6. A method for preparing a medicament for treating osteoporosis according to claim 5, characterized in that, The ratio of material to liquid in the vinegar extraction is 1:(6-8); the extraction temperature is 90-110℃; and the extraction time is 3-5 hours.

7. A method for preparing a medicament for treating osteoporosis according to claim 5, characterized in that, The vegetable oil is a mixture of walnut oil and avocado oil in a mass ratio of 1:(0.8-1.2).

8. A method for preparing a medicament for treating osteoporosis according to claim 7, characterized in that, The ratio of material to liquid in the vegetable oil extraction is 1:(8-10).

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