A TEAD inhibitory protein polypeptide TEAi for bone tissue regeneration and its application

CN118909051BActive Publication Date: 2025-09-23STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
View PDF 1 Cites 0 Cited by

Patent Information

Application Number
CN202410981461.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-07-22
Publication Date
2025-09-23
Estimated Expiration
2044-07-22

Smart Images

  • Figure CN118909051B_ABST
    Figure CN118909051B_ABST
Patent Text Reader

Abstract

The present invention belongs to the fields of medicine and polypeptide technology, and discloses a TEAD inhibitory protein polypeptide TEAi for bone tissue regeneration, wherein the amino acid sequence of the TEAi is: SEQ ID NO.1. The present invention is the first to select and apply a protein polypeptide inhibitor (TEAi) targeting the N-terminus of TEAD to promote the osteogenic differentiation of PDLSCs and the mediated bone tissue regeneration in vivo. The present invention provides an effective polypeptide molecule for stem cell-mediated bone tissue regeneration, which can be applied clinically to promote bone tissue regeneration in patients with craniomaxillofacial bone tissue defects.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • TEAD inhibitory polypeptide and application thereof

    CN118852396A