A tumor in vitro sample pretreatment and information collection device, system and method

Abstract

The present invention belongs to the technical field of medical devices, and specifically relates to a tumor ex vivo sample pretreatment and information collection device, wherein a processing box is provided on the upper surface of the table, a flexible cushion layer is provided between the processing box and the table, a box cover is provided at the upper end of the processing box, a support plate is contacted on the right side of the upper end of the table, an intelligent terminal is provided at the upper end of the support plate, and a curing treatment mechanism is provided on the processing box. Through the provision of a processing dish, this scheme can place and use tumor ex vivo samples, and under the action of the annular electromagnet connected to the pulse current, the annular electromagnet intermittently adsorbs the magnetic block, and cooperates with the deformation effect of spring 1, so that the agitation plate can be continuously moved to agitate the formalin solution, thereby improving the curing effect of the tumor ex vivo sample, so as to complete the tissue fixation treatment of the tumor ex vivo sample.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to a tumor in vitro sample pretreatment and information collection device. Background Art

[0002] As we all know, the in vitro tumor sample pretreatment and information collection device is a device used to process and collect information from in vitro tumor samples. These devices are usually used in scientific research laboratories or clinical research to study the biological characteristics of tumors, treatment responses, etc.

[0003] Generally speaking, ex vivo samples need to be placed in at least 5 volumes of formalin tissue preservation solution or RNAlater tissue preservation solution for 30 minutes, otherwise DNA / RNA will degrade over time or if fixation is insufficient. Samples should be sent for testing as soon as possible after collection, and should be sent to the laboratory within 72 hours. The transportation temperature should be 10-30°C. Too high or too low a temperature will have an adverse effect on subsequent processing.

[0004] If the fresh tissue cannot be delivered to the laboratory in a short time, the ex vivo samples need to be placed in a -80℃ refrigerator as soon as possible for projects based on DNA detection; the ex vivo samples need to be chopped to a maximum thickness of at least one side of no more than 0.5cm, and then the tissue fragments are quickly placed in 5 times the volume of RNAlater, placed at 4℃ overnight, and then transferred to -20℃ for storage. If it needs to be transferred to a -80℃ refrigerator, it is necessary to place it at 4℃ overnight, then remove the sample from RNAlater and store it in a -80℃ refrigerator.

[0005] In the laboratory / pathology department, the tissue needs to be fully fixed for 6-24 hours before sampling. The tissue is cut into small blocks, and then these small blocks are placed in a dehydrator for dehydration, transparency, and wax immersion. Each small block is then embedded in paraffin, and the small block needs to be immersed in wax liquid, and after cooling, a mold with the specimen is formed. Then the slices are cut on a microtome.

[0006] The pretreatment of tumor tissue samples is relatively complicated. If the operation is neglected, it is very easy to have an adverse effect on subsequent inspections. Therefore, in order to simplify the relevant pretreatment operations and improve the inspection effect, a tumor tissue sample collection and pretreatment device is disclosed in the patent authorization announcement number CN215931475U, including a box body, the box body is provided with a placement cavity, the right side of the box body is provided with a sealing groove, the left inner wall of the sealing groove is provided with a connecting hole, the inner surface of the sealing groove is movably connected to a sealing plate, the left side of the sealing plate is fixedly connected to a storage plate, the top of the storage plate is provided with a dehydration groove and a fixing groove, the upper part of the left inner wall of the sealing groove is provided with a limiting groove, the inner surface of the limiting groove is movably connected to the limiting plate, the right side of the sealing plate is fixedly connected to a pull rod, and the inner top wall of the placement cavity is provided with a placement groove.

[0007] Existing in vitro tumor sample pretreatment devices have certain shortcomings. First, when the above-mentioned device pretreats the in vitro tumor samples, it directly immerses the in vitro tumor samples in formalin solution for fixation. Since the fixation of in vitro tumor samples is closely related to factors such as the ambient temperature and fluid rate, simple static immersion will cause uneven infiltration during fixation (due to the different morphologies of in vitro samples). Secondly, during the pretreatment, various information on the pretreatment of the in vitro tumor samples needs to be collected to facilitate subsequent diagnosis (even to determine whether the various pretreatment operations affect subsequent staining and diagnosis). Generally speaking, when the in vitro tumor samples are immersed in formalin solution for fixation, excessive oscillation and stirring should be avoided, because this will increase the risk of sample tissue fragmentation or deformation and affect the integrity of the tissue structure.

[0008] However, in order to ensure that the fixative can fully penetrate into the tissue, moderate flipping of the sample can improve the consistency of the fixation effect, especially for some larger tumor samples, which need to be gently flipped. However, if it is done manually, it is very easy to cause more violent vibrations due to improper operation, affecting the integrity and fixation effect of the in vitro sample.

[0009] Therefore, a device, system and method for preprocessing and collecting information of tumor ex vivo samples are now provided, which can not only collect various information during the preprocessing process, but also appropriately stir the ex vivo samples according to the actual conditions of the ex vivo samples during the preprocessing process. Summary of the invention

[0010] The purpose of the present invention is to provide a tumor ex vivo sample pretreatment and information collection device, which can collect various information during the pretreatment process and can appropriately stir the ex vivo sample according to the actual situation of the ex vivo sample during the pretreatment process.

[0011] In order to achieve the above-mentioned object, the present invention provides a tumor ex vivo sample pretreatment and information collection device, comprising a table, a processing box is provided on the upper surface of the table, a flexible cushion layer is provided between the processing box and the table, a box cover is provided at the upper end of the processing box, a support plate is contacted on the right side of the upper end of the table, an intelligent terminal is provided at the upper end of the supporting plate, and a curing treatment mechanism is provided on the processing box;

[0012] The curing treatment mechanism includes a treatment dish, and the treatment dishes are two and symmetrically arranged at the inner bottom of the treatment box. A first pressure-sensitive patch and a second pressure-sensitive patch for detecting the pressure in the treatment dish are respectively arranged between the bottom of the treatment dish and the bottom of the treatment box. A flexible connecting piece fixed to the treatment dish and the treatment box is arranged between the treatment dish and the treatment box. The first pressure-sensitive patch and the second pressure-sensitive patch are respectively fixedly connected to the bottom of the treatment dish, and the first pressure-sensitive patch and the second pressure-sensitive patch are respectively connected to the smart terminal signal;

[0013] The side surface of each processing dish is provided with a plurality of liquid inlet micro-holes arranged in a circular array, the interior of the processing box is slidably connected with a telescopic rod, the outer side of the telescopic rod is fixedly sleeved with an agitation plate, the agitation plate is slidably connected to the processing box, the back end of the telescopic rod is fixedly connected with a fixed disk, a spring 1 is arranged on the outer side of the telescopic rod, and the front end of the telescopic rod is fixedly connected with a magnetic block; one end of the spring 1 is fixedly connected to the fixed disk, and the other end of the spring 1 is fixedly connected to the processing box; an annular electromagnet is fixedly installed on the front side of the processing box, the annular electromagnet is slidably connected to the telescopic rod, and the annular electromagnet is connected to the intelligent terminal control;

[0014] The intelligent terminal is used to receive a first pressure signal detected by a first pressure-sensitive patch and a second pressure signal detected by a second pressure-sensitive patch, and when the first pressure signal and the second pressure signal change from zero to have a reading, generate a first excitation signal according to the reading range of the first pressure signal and the second pressure signal, and control the working frequency and magnetic field strength of the annular electromagnet according to the excitation signal; then enter a reduced amplitude mode when the reading change rate of the first pressure signal and the second pressure signal exceeds a preset range, and the reduced amplitude mode is to generate a second excitation signal, the second excitation signal and the first excitation signal have a small amplitude and the same frequency in the same period, and then again determine whether the reading change rate of the first pressure signal and the second pressure signal exceeds the preset range, if so, repeat the reduced amplitude mode; if not, maintain the most recent second excitation signal;

[0015] The intelligent terminal is also used to record the time parameters when the first pressure signal and the second pressure signal change from zero to have readings, the pressure parameters of the first pressure signal and the second pressure signal readings changing over time, and to give a voice reminder when the timing reaches a preset time.

[0016] The principle of the present invention is to place the tumor sample in vitro in a processing box, which is provided with two symmetrical processing dishes with first and second pressure-sensitive patches at the bottom. The pressure-sensitive patches are used to detect the pressure in the processing dishes. The telescopic rod is connected to the agitation plate, which is slidably connected to the processing box through the telescopic rod to achieve gentle agitation of the sample, remove blood, impurities, etc. on the surface of the sample, and improve the solidification effect.

[0017] By connecting the annular electromagnet to a pulse current, the magnetic attraction direction of the annular electromagnet is intermittently changed. When the annular electromagnet magnetically attracts the magnetic block, it can drive the telescopic rod to move, thereby driving the agitation plate to move, and driving the fixed plate to move in a direction away from the processing box. Once the spring is deformed, when the annular electromagnet no longer magnetically attracts the magnetic block, the spring recovers its deformation to pull the fixed plate to move in a direction close to the processing box, thereby driving the telescopic rod to move, and finally driving the agitation plate to move, and this cycle is repeated, so that the agitation plate is continuously moved in the formalin solution, the formalin solution is agitated, and the setting of the liquid inlet micropores can ensure the rapid circulation of the formalin solution, thereby solidifying the three-dimensional tumor sample.

[0018] Through the intermittent magnetic attraction of the annular electromagnet, and in conjunction with the deformation of the magnetic block and spring 1, the telescopic rod can drive the agitation plate to move back and forth to agitate the formalin solution. By connecting the annular electromagnet to a pulse current, the magnetic attraction direction of the annular electromagnet can be intermittently changed.

[0019] The side surface of each processing dish is provided with a plurality of liquid inlet micropores arranged in a circular array, which can block the waves generated by the stirring plate and decompose them into several small impacts, which not only reduces the direct impact of the waves on the in vitro sample, but also makes the impact force smaller and more dispersed. When the water waves pass through the liquid inlet micropores, they will form several secondary water waves with the liquid inlet micropores as the origin according to the wave transmission characteristics, and interact with each other, which improves the contact reaction efficiency between the solution and the in vitro sample, and when the secondary water waves contact the side wall inside the processing dish, they will also be reflected to avoid excessive squeezing of the in vitro sample and the side wall of the processing dish. At the same time, it is avoided that the in vitro sample and the container side wall are excessively contacted and squeezed due to excessive impact, resulting in drastic changes in the morphology of the in vitro sample.

[0020] The first and second pressure-sensitive patches detect the pressure changes in their respective processing dishes and transmit the signals to the smart terminal. The smart terminal receives the pressure signal and generates an excitation signal to control the working frequency and magnetic field strength of the annular electromagnet when the pressure signal changes, thereby adjusting the movement of the excitation plate to achieve moderate stirring of the sample. When the rate of change of the pressure signal exceeds the preset range, the smart terminal enters the amplitude reduction mode and generates a second excitation signal to reduce the excitation intensity and avoid damage to the sample.

[0021] The intelligent terminal records the changes in the pressure signal and keeps a complete record of the entire process for easy traceability. It also issues a voice reminder when the preset time is reached to ensure the accuracy and timeliness of the pretreatment process.

[0022] The beneficial effects of the present invention are as follows: through moderate stirring of the agitation plate, it is possible to ensure that the fixative penetrates more evenly into the interior of the sample, thereby improving the fixation effect. The intelligent terminal can collect and record the pressure changes of the sample during the pretreatment process in real time, providing important data for subsequent diagnosis and analysis. The agitation intensity is automatically adjusted according to the changes in the pressure signal, avoiding the irregularities and sample damage risks that may be caused by manual operation. The device is suitable for in vitro tumor samples of different sizes and shapes, and has good adaptability and versatility. Through flexible connection and moderate agitation, the breakage or deformation of the sample during the pretreatment process is reduced, and the integrity of the tissue structure is protected. Through intelligent control and information collection, the device of the present invention can improve the quality of in vitro tumor sample pretreatment, and provide a more reliable basis for subsequent pathological analysis and diagnosis.

[0023] In summary, the present invention can achieve the effect of being able to collect various information during the pretreatment process, and being able to appropriately stir the in vitro sample according to the actual situation of the in vitro sample during the pretreatment process.

[0024] Furthermore, a rotating mechanism is arranged on the table top, and the rotating mechanism includes a rotating shaft, a rotating shaft is installed inside the table top through a bearing, the rotating shaft is fixedly connected to the supporting plate, a gear 1 is fixedly sleeved on the outer side of the rotating shaft, a motor is fixedly installed at the lower end of the table top and on the left side of the rotating shaft, a gear 2 is fixedly sleeved on the outer side of the output shaft of the motor, the gear 2 is meshed with the gear 1, a positioning hole is opened at the lower end of the table top, a rotating plate is fixedly sleeved on the outer side of the output shaft of the motor, the upper end of the rotating plate is fixedly connected to two symmetrically distributed guide rods, the outer sides of the two guide rods are slidably sleeved with a top plate, the vertical rod of the top plate is fixedly connected with a positioning ball, and the positioning ball is slidably connected to the positioning hole; a spring 2 is welded to the lower end of the top plate, and the other end of the spring 2 is welded to the rotating plate.

[0025] The starting motor drives the output shaft to rotate, thereby driving gear 2 to rotate. Under the meshing relationship, gear 2 drives gear 1 to rotate, thereby driving the rotating shaft to rotate, and then driving the support plate to rotate, and finally driving the smart terminal to rotate, adjusting the position of the smart terminal for subsequent use by medical personnel.

[0026] During this process, when the motor drives the output shaft to rotate, the rotating plate can be driven to rotate. Under the action of force, the inner wall of the positioning hole squeezes the positioning ball to push the top plate to move along the surface of the guide rod. The second spring is deformed, and finally drives the positioning ball out of the positioning hole. Under the action of force, the positioning ball moves along the surface of the table. When the positioning ball slides into the next positioning hole, the second spring restores its deformation to push the positioning ball into the positioning hole, thereby limiting the output shaft of the motor, and then accurately controlling the position of the smart terminal.

[0027] The motor, gear 2 and other structures can drive the intelligent terminal to rotate, adjust the position of the intelligent terminal, and facilitate the use of medical personnel. Under the action of the positioning hole, positioning ball and other structures, the gear 2 can be limited, and the position of the intelligent terminal can be finely controlled. That is, through the coordinated use of the motor, gear 2 and other structures, the rotating shaft can be driven to rotate, so as to drive the intelligent terminal to rotate, adjust the position of the intelligent terminal, and facilitate the use of medical personnel. Under the action of the positioning hole, positioning ball and other structures, the position of the intelligent terminal can be finely controlled. Through the setting of spring 2, the top plate can be tightened.

[0028] And through the role of the positioning ball, the table surface can also have a certain acceleration / vibration in the vertical direction, thereby improving the ability to create tiny water waves.

[0029] Furthermore, a top block capable of contacting the processing box during the rotation of the supporting disk is provided on the side surface of the supporting disk, and the top block is fixedly connected to the supporting disk.

[0030] Furthermore, the processing box is also provided with a temperature detection module, which is fixed at the bottom of the processing box. The temperature detection module is used to detect the temperature of the solution in the processing box, and the temperature detection module is connected to the intelligent terminal signal.

[0031] Furthermore, two symmetrically distributed supporting legs are fixedly connected to the lower end of the table top.

[0032] Furthermore, the positioning holes are provided in plurality, and the plurality of positioning holes are arranged in a circular array on the table surface. The positioning holes are provided so as to facilitate the use of the positioning balls for clamping.

[0033] Furthermore, the smart terminal is also provided with an acceleration module, which is connected to the smart terminal signal, and is used to detect the acceleration change of the table surface, and generate a warning message when the acceleration value on the table surface changes beyond a preset value.

[0034] Furthermore, it also includes a semiconductor temperature regulation module, which includes a cold end plate and a hot end plate, the cold end plate is fixedly connected to the excitation plate, and the hot end plate is fixed on the fixed disk; the cold end plate and the hot end plate are both electrically connected to the smart terminal. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 A three-dimensional diagram of the overall structure of the device for preprocessing and collecting information of an in vitro tumor sample according to an embodiment of the present invention;

[0036] Figure 2 The invention is a device for preprocessing and collecting information of tumor samples in vitro. Figure 1 A top view of the box with the lid removed;

[0037] Figure 3 The invention is a device for preprocessing and collecting information of tumor samples in vitro. Figure 1 A bottom-up stereogram of

[0038] Figure 4 The invention is a device for preprocessing and collecting information of tumor samples in vitro. Figure 3 Enlarged view of point A. DETAILED DESCRIPTION

[0039] The following is further described in detail through specific implementation methods:

[0040] The marks in the drawings of the specification include: table 1, supporting legs 2, processing box 3, box cover 4, supporting plate 5, intelligent terminal 6, curing processing mechanism 7, rotating mechanism 8, processing dish 71, liquid inlet micropore 72, telescopic rod 73, exciting plate 74, fixed plate 75, spring 1 76, magnetic block 77, annular electromagnet 78, rotating shaft 81, gear 1 82, motor 83, gear 2 84, positioning hole 85, rotating plate 86, guide rod 87, top plate 88, spring 2 89, positioning ball 890.

[0041] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, this embodiment provides a tumor ex vivo sample pretreatment and information collection device, including a table top 1, the lower end of the table top 1 is fixedly connected to two symmetrically distributed supporting legs 2, the upper left end of the table top 1 is fixedly connected to a processing box 3, the upper end of the processing box 3 is provided with a box cover 4, the upper right end of the table top 1 is in contact with a supporting plate 5, and the upper end of the supporting plate 5 is provided with an intelligent terminal 6.

[0042] like Figure 1 , Figure 2 , Figure 3As shown, a curing treatment mechanism 7 is provided on the processing box 3, and the curing treatment mechanism 7 includes a processing dish 71. Two symmetrically distributed processing dishes 71 are provided on the inner bottom of the processing box 3;

[0043] A first pressure-sensitive patch and a second pressure-sensitive patch for detecting the pressure in the processing dish 71 are respectively provided between the bottom of the processing dish 71 and the bottom of the processing box 3, and a flexible connector fixed to the processing dish 71 and the processing box 3 is provided between the processing dish 71 and the processing box 3, and the first pressure-sensitive patch and the second pressure-sensitive patch are respectively fixedly connected to the bottom of the processing dish 71, and the first pressure-sensitive patch and the second pressure-sensitive patch are respectively connected to the smart terminal 6 by signal;

[0044] The surface of each processing dish 71 is provided with a plurality of liquid inlet micropores 72 arranged in a circular array, a telescopic rod 73 is slidably connected to the inside of the processing box 3, an agitation plate 74 is fixedly sleeved on the outside of the telescopic rod 73, the agitation plate 74 is slidably connected to the processing box 3, a fixed disk 75 is fixedly connected to the back end of the telescopic rod 73, a spring 76 is arranged on the outside of the telescopic rod 73, a magnetic block 77 is fixedly connected to the front end of the telescopic rod 73, through the intermittent magnetic attraction of the annular electromagnet 78 and the deformation of the magnetic block 77 and the spring 76, the telescopic rod 73 can drive the agitation plate 74 to move back and forth to agitate the formalin solution. The annular electromagnet 78 is controlled and connected to the intelligent terminal 6 (the specific power supply circuit of the annular magnet has several branches, each branch has relays and resistors with different resistance values, and the power control of the annular electromagnet 78 is realized by connecting and combining the relays. Each relay is connected to the signal of the intelligent terminal 6. Of course, an encoder can also be added between the intelligent terminal 6 and the relay. The specific structure can be selected by technical personnel in this field according to actual needs and power).

[0045] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, one end of a spring 76 is welded to a fixed disk 75, and the other end of a spring 76 is welded to a processing box 3. By setting a spring 76, the fixed disk 75 can be connected for use. An annular electromagnet 78 is fixedly installed on the front of the processing box 3. The annular electromagnet 78 is slidably connected to the telescopic rod 73. By connecting a pulse current (and the magnitude of the pulse current) to the annular electromagnet 78, the magnetic attraction direction (and the magnitude and frequency of the magnetic attraction force) of the annular electromagnet 78 can be intermittently changed.

[0046] The intelligent terminal 6 is used to receive the first pressure signal detected by the first pressure-sensitive patch and the second pressure signal detected by the second pressure-sensitive patch, and when the first pressure signal and the second pressure signal change from zero to have a reading (that is, when the in vitro sample is loaded into the processing dish), generate a first excitation signal according to the reading range of the first pressure signal and the second pressure signal (equivalent to the larger the in vitro sample, the stronger the water wave is needed), and control the working frequency and magnetic field strength of the annular electromagnet 78 according to the excitation signal; then enter the amplitude reduction mode when the reading change rate of the first pressure signal and the second pressure signal exceeds the preset range, and the amplitude reduction mode is to generate a second excitation signal, the second excitation signal and the first excitation signal have a small amplitude and the same frequency in the same period (this method can make the water wave quickly reduce, and avoid the occurrence of excessive water wave strength caused by similar resonance through feedback), and then judge again whether the reading change rate of the first pressure signal and the second pressure signal exceeds the preset range, if so, repeat the amplitude reduction mode; otherwise, keep the most recent second excitation signal;

[0047] The intelligent terminal 6 is also used to record the time parameters when the first pressure signal and the second pressure signal change from zero to have readings, the pressure parameters of the first pressure signal and the second pressure signal readings changing over time, and to give a voice reminder when the timing reaches a preset time.

[0048] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, a rotating mechanism 8 is provided on the table 1, and the rotating mechanism 8 includes a rotating shaft 81. The rotating shaft 81 is installed inside the table 1 through a bearing. The rotating shaft 81 is fixedly connected to the support plate 5. A gear 1 82 is fixedly sleeved on the outer side of the rotating shaft 81. A motor 83 is fixedly installed at the lower end of the table 1 and located on the left side of the rotating shaft 81. A gear 2 84 is fixedly sleeved on the outer side of the output shaft of the motor 83. The gear 2 84 meshes with the gear 1 82. A positioning hole 85 is opened at the lower end of the table 1. A rotating plate 86 is fixedly sleeved on the outer side of the output shaft of the motor 83. The upper end of the rotating plate 86 Two symmetrically distributed guide rods 87 are fixedly connected, and the outer sides of the two guide rods 87 are slidably sleeved with a top plate 88. The vertical rod of the top plate 88 is fixedly connected with a positioning ball 890, and the positioning ball 890 is slidably connected to the positioning hole 85. Through the coordinated use of the motor 83, the gear 2 84 and other structures, the rotating shaft 81 can be driven to rotate, so as to drive the intelligent terminal 6 to rotate, and the position of the intelligent terminal 6 can be adjusted to facilitate the use of medical personnel. Under the action of the positioning hole 85, the positioning ball 890 and other structures, the position of the intelligent terminal 6 can be finely controlled.

[0049] like Figure 1 , Figure 2 , Figure 3 , Figure 4As shown, a plurality of positioning holes 85 are provided, and the plurality of positioning holes 85 are arranged in a circular array on the table top 1. The provision of the positioning holes 85 facilitates the use of the positioning balls 890 for clamping. A spring 89 is welded to the lower end of the top plate 88, and the other end of the spring 89 is welded to the rotating plate 86. The provision of the spring 89 allows the top plate 88 to be tightened.

[0050] The specific implementation process of the present invention is as follows: by connecting the annular electromagnet 78 to the pulse current, the magnetic attraction direction of the annular electromagnet 78 is intermittently changed. When the annular electromagnet 78 magnetically attracts the magnetic block 77, the telescopic rod 73 can be driven to move, so as to drive the agitation plate 74 to move, and drive the fixed plate 75 to move in the direction away from the processing box 3, and the spring 1 76 is deformed. When the annular electromagnet 78 no longer magnetically attracts the magnetic block 77, the spring 1 76 recovers its deformation to pull the fixed plate 75 to move in the direction close to the processing box 3, thereby driving the telescopic rod 73 to move, and finally driving the agitation plate 74 to move, and the cycle repeats, so that the agitation plate 74 is continuously moved in the formalin solution, the formalin solution is agitated, and the setting of the liquid inlet micropore 72 can ensure the rapid circulation of the formalin solution, thereby solidifying the three-dimensional tumor sample;

[0051] The starting motor 83 drives the output shaft to rotate, so as to drive the gear 2 84 to rotate. Under the meshing relationship, the gear 2 84 drives the gear 1 82 to rotate, so as to drive the rotating shaft 81 to rotate, and then drives the supporting plate 5 to rotate, and finally drives the intelligent terminal 6 to rotate, and adjusts the position of the intelligent terminal 6 for the subsequent use of medical personnel. In this process, when the motor 83 drives the output shaft to rotate, it can drive the rotating plate 86 to rotate. Under the action of force, the inner wall of the positioning hole 85 squeezes the positioning ball 890 to push the top plate 88 to move along the surface of the guide rod 87, and the spring 2 89 is deformed, and finally drives the positioning ball 890 to disengage from the positioning hole 85. Under the action of force, the positioning ball 890 moves along the surface of the table 1. When the positioning ball 890 slides into the next positioning hole 85, the spring 2 89 restores its deformation to push the positioning ball 890 to insert into the positioning hole 85, limit the output shaft of the motor 83, and then accurately control the position of the intelligent terminal 6.

[0052] This solution can place and use tumor ex vivo samples by setting up the processing dish 71. When the annular electromagnet 78 is connected to the pulse current, the annular electromagnet 78 intermittently adsorbs the magnetic block 77, and cooperates with the deformation of the spring 1 76 to make the agitation plate 74 move continuously to agitate the formalin solution, thereby improving the solidification effect of the tumor ex vivo sample and completing the tissue fixation treatment of the tumor ex vivo sample. Through the setting of the intelligent terminal 6, the tumor ex vivo sample tissue can be imaged with high resolution digitally to obtain cell structure and morphological information to complete the information collection operation. Under the action of the motor 83, the gear 2 84 and other structures, the intelligent terminal 6 can be driven to rotate and the position of the intelligent terminal 6 can be adjusted to facilitate the use of medical personnel. Under the action of the positioning hole 85, the positioning ball 890 and other structures, the gear 2 84 can be limited, and then the position of the intelligent terminal 6 can be finely controlled.

[0053] In another embodiment, a top block capable of contacting the processing box 3 during the rotation of the support disk 5 is provided on the side of the support disk 5, and the top block is fixedly connected to the support disk 5. Such a design enables the processing box 3 to generate water waves in the horizontal direction when the support disk 5 rotates, thereby improving the ability to generate tiny water waves and facilitating the solidification process of smaller in vitro samples (avoiding a large impact of the water flow generated by the agitation plate 74).

[0054] The processing box 3 is also provided with a temperature detection module, which is fixed at the bottom of the processing box 3. The temperature detection module is used to detect the temperature of the solution in the processing box 3, and the temperature detection module is connected to the intelligent terminal 6 by signal. It also includes a semiconductor temperature adjustment module (equivalent to a semiconductor refrigeration sheet), which includes a cold end plate and a hot end plate, the cold end plate is fixedly connected to the agitation plate 74, and the hot end plate is fixed on the fixed plate 75; the cold end plate and the hot end plate are both electrically connected to the intelligent terminal 6.

[0055] During specific use, the hot end plate can also dissipate heat when the fixed disk 75 moves, which can ensure that the temperature of the entire curing process is low.

[0056] In another embodiment, the smart terminal 6 is further provided with an acceleration module, which is signal-connected to the smart terminal 6 and is used to detect the acceleration change of the table 1 and generate a warning message when the acceleration value on the table 1 changes beyond a preset value.

[0057] When in use, the intelligent terminal 6 is an intelligent device similar to a smart phone or a platform, which can record information more comprehensively through the acceleration module.

[0058] It should be noted in advance that, in the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0059] The above is only an embodiment of the present invention, and the common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several deformations and improvements can be made without departing from the structure of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A device for preprocessing and collecting information of tumor samples in vitro, comprising a table, characterized in that: A processing box is provided on the upper surface of the table, a flexible cushion layer is provided between the processing box and the table, a box cover is provided at the upper end of the processing box, a support plate is contacted on the right side of the upper end of the table, a smart terminal is provided at the upper end of the support plate, and a curing processing mechanism is provided on the processing box; The curing treatment mechanism includes a treatment dish, and the treatment dishes are two and symmetrically arranged at the inner bottom of the treatment box. A first pressure-sensitive patch and a second pressure-sensitive patch for detecting the pressure in the two treatment dishes are respectively arranged between the bottoms of the two treatment dishes and the bottom of the treatment box. A flexible connecting piece fixed to the two treatment dishes and the treatment box is arranged between the treatment dishes and the treatment box. The first pressure-sensitive patch and the second pressure-sensitive patch are respectively fixedly connected to the bottoms of the two treatment dishes, and the first pressure-sensitive patch and the second pressure-sensitive patch are respectively connected to the smart terminal signal; The side surface of each processing dish is provided with a plurality of liquid inlet micro-holes arranged in a circular array, the interior of the processing box is slidably connected with a telescopic rod, the outer side of the telescopic rod is fixedly sleeved with an agitation plate, the agitation plate is slidably connected to the processing box, the back end of the telescopic rod is fixedly connected with a fixed disk, a spring 1 is arranged on the outer side of the telescopic rod, and the front end of the telescopic rod is fixedly connected with a magnetic block; one end of the spring 1 is fixedly connected to the fixed disk, and the other end of the spring 1 is fixedly connected to the processing box; an annular electromagnet is fixedly installed on the front side of the processing box, the annular electromagnet is slidably connected to the telescopic rod, and the annular electromagnet is connected to the intelligent terminal control; The intelligent terminal is used to receive a first pressure signal detected by a first pressure-sensitive patch and a second pressure signal detected by a second pressure-sensitive patch, and when the first pressure signal and the second pressure signal change from zero to have a reading, generate a first excitation signal according to the reading range of the first pressure signal and the second pressure signal, and control the working frequency and magnetic field strength of the annular electromagnet according to the excitation signal; then enter a reduced amplitude mode when the reading change rate of the first pressure signal and the second pressure signal exceeds a preset range, and the reduced amplitude mode is to generate a second excitation signal, the second excitation signal and the first excitation signal have a small amplitude and the same frequency in the same period, and then again determine whether the reading change rate of the first pressure signal and the second pressure signal exceeds the preset range, if so, repeat the reduced amplitude mode; if not, maintain the most recent second excitation signal; The intelligent terminal is also used to record the time parameters when the first pressure signal and the second pressure signal change from zero to have readings, the pressure parameters of the first pressure signal and the second pressure signal readings changing over time, and to give a voice reminder when the timing reaches a preset time.

2. The device for preprocessing and collecting information of tumor samples in vitro according to claim 1, characterized in that: A rotating mechanism is arranged on the table top, and the rotating mechanism includes a rotating shaft. The rotating shaft is installed inside the table top through a bearing, and the rotating shaft is fixedly connected to the supporting plate. A gear 1 is fixedly sleeved on the outer side of the rotating shaft. A motor is fixedly installed at the lower end of the table top and on the left side of the rotating shaft. A gear 2 is fixedly sleeved on the outer side of the output shaft of the motor, and the gear 2 is meshed with the gear 1. A positioning hole is opened at the lower end of the table top, and a rotating plate is fixedly sleeved on the outer side of the output shaft of the motor. The upper end of the rotating plate is fixedly connected to two symmetrically distributed guide rods, and a top plate is slidably sleeved on the outer sides of the two guide rods. A positioning ball is fixedly connected to the vertical rod of the top plate, and the positioning ball is slidably connected to the positioning hole; a spring 2 is welded to the lower end of the top plate, and the other end of the spring 2 is welded to the rotating plate.

3. The device for preprocessing and collecting information of tumor samples in vitro according to claim 2, characterized in that: A top block capable of contacting the processing box during the rotation of the supporting disk is arranged on the side surface of the supporting disk, and the top block is fixedly connected to the supporting disk.

4. The device for preprocessing and collecting information of tumor samples in vitro according to claim 3, characterized in that: The processing box is also provided with a temperature detection module, which is fixed at the bottom of the processing box. The temperature detection module is used to detect the temperature of the solution in the processing box, and the temperature detection module is connected to the intelligent terminal signal.

5. The device for preprocessing and collecting information of in vitro tumor samples according to claim 4, characterized in that: The lower end of the table top is fixedly connected with two symmetrically distributed supporting legs.

6. The device for preprocessing and collecting information of in vitro tumor samples according to claim 5, characterized in that: A plurality of positioning holes are provided, and the plurality of positioning holes are arranged in a circular array on the table surface.

7. The device for preprocessing and collecting information of in vitro tumor samples according to claim 6, characterized in that: The smart terminal is also provided with an acceleration module, which is connected to the smart terminal signal. The acceleration module is used to detect the acceleration change of the table surface and generate a warning message when the acceleration value on the table surface changes beyond a preset value.

8. The device for preprocessing and collecting information of in vitro tumor samples according to claim 7, characterized in that: It also includes a semiconductor temperature regulation module, which includes a cold end plate and a hot end plate, the cold end plate is fixedly connected to the excitation plate, and the hot end plate is fixed on the fixed disk; the cold end plate and the hot end plate are both electrically connected to the smart terminal.

9. A tumor in vitro sample pretreatment and information collection system, characterized in that: A device as described in any one of claims 1 to 7 is used.

10. A method for preprocessing and collecting information of tumor samples in vitro, characterized in that: A device as described in any one of claims 1 to 7 is used.

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