A surfactant complex with reduced ocular irritation

Abstract

The present invention belongs to the technical field of surfactant preparation, and specifically relates to a surfactant complex with reduced eye irritation. The preparation method provided by the present invention includes the following steps: mixing aminocyclodextrin, sodium cocoyl amphoacetate and water, performing ultrasonic treatment after mixing, adding lactic acid to the mixed solution, heating and stirring, cooling, adding capryloyl / capryl amidopropyl betaine, sodium methyl cocoyl taurate and glycolipid, and stirring and mixing to obtain the surfactant complex; the mass ratio of aminocyclodextrin, sodium cocoyl amphoacetate and water is (3-7):(20-30):(50-70); the mass ratio of aminocyclodextrin and lactic acid is (4-8):(0.2-1); the mass ratio of sodium cocoyl amphoacetate, capryloyl / capryl amidopropyl betaine, sodium methyl cocoyl taurate and glycolipid is (20-30):(3-7):(2-5):(2-5). The surfactant complex prepared by the present invention has high viscosity and stability.

Description

Technical Field

[0001] The present invention belongs to the technical field of surfactant preparation, and particularly relates to a surfactant complex with reduced eye irritation. Background Art

[0002] As an important component in personal care products, surfactants have received increasing attention. Some existing surfactants have certain irritation, especially strong irritation to eyes and skin. With the improvement of people's living standards and the increasing awareness of health protection, people have paid more and more attention to mild and low-irritation surfactants.

[0003] Sodium cocoyl amphoacetate, as an amphoteric surfactant, has a stable molecular structure and can exhibit excellent surface activity performance in neutral, acidic, and alkaline environments. At the same time, it has low irritation and is widely used in fields such as facial cleansers, shampoos, and cosmetic lotions. However, when sodium cocoyl amphoacetate is used as the main component of a surfactant complex, the complex is difficult to thicken, has a low viscosity, and its stability needs to be improved. Summary of the Invention

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the defects that when sodium cocoyl amphoacetate is used as the main component of a surfactant complex, the complex has a low viscosity and its stability needs to be improved, and then to provide a surfactant complex with reduced eye irritation.

[0005] To solve the above problems, the technical solution of the present invention is as follows:

[0006] A method for preparing a surfactant complex, comprising the following steps:

[0007] Mix aminocyclodextrin, sodium cocoyl amphoacetate, and water, perform ultrasonic treatment after mixing, and after the ultrasonic treatment ends, add lactic acid to the mixed solution, heat and stir, cool down after the heating and stirring ends, and then add capryloyl / capryl amidopropyl betaine, sodium methyl cocoyl taurate, and glycolipid, and stir and mix to obtain the surfactant complex;

[0008] The mass ratio of the aminocyclodextrin, sodium cocoyl amphoacetate, and water is (3 - 7):(20 - 30):(50 - 70);

[0009] The mass ratio of the aminocyclodextrin and lactic acid is (4 - 8):(0.2 - 1);

[0010] The mass ratio of the sodium cocoyl amphoacetate, capryloyl / capryl amidopropyl betaine, sodium methyl cocoyl taurate, and glycolipid is (20 - 30):(3 - 7):(2 - 5):(2 - 5).

[0011] Preferably, in the ultrasonic treatment, the ultrasonic temperature is 45 - 50 °C, the ultrasonic frequency is 100 - 150 KHZ, and the ultrasonic time is 60 - 120 min.

[0012] Preferably, the heating and stirring temperature is 60 - 80 °C, the heating and stirring time is 20 - 60 min, and the heating and stirring rate is 400 - 800 r / min;

[0013] The stirring and mixing temperature is 50 - 60 °C, and the stirring and mixing time is 0.5 - 3 h.

[0014] Preferably, after the heating and stirring, the temperature is lowered to room temperature.

[0015] Preferably, the glycolipid is rhamnolipid.

[0016] Preferably, by mass fraction, the contents of the raw materials in the surfactant complex include 20 - 30% of sodium cocoyl amphoacetate, 1 - 8% of capryloyl / capryl amidopropyl betaine, 2 - 10% of sodium methyl cocoyl taurate, 2 - 6% of rhamnolipid, 3 - 7% of aminocyclodextrin, 0.2 - 0.8% of lactic acid, and 55 - 68.2% of water. It can be understood that the dosages of the raw materials in the present invention refer to the dosages of the active substances (effective components) in the raw materials.

[0017] The present invention also provides a surfactant complex with reduced eye irritation, which is prepared by the preparation method described above.

[0018] The technical solution of the present invention has the following advantages:

[0019] In the preparation method of the surfactant complex provided by the present invention, first, sodium cocoyl amphoacetate and aminocyclodextrin are mixed and ultrasonically treated. Since β - cyclodextrin has a conical hollow cylindrical structure with a hydrophobic region formed in the cavity, in the present invention, aminocyclodextrin, sodium cocoyl amphoacetate, and water are mixed and then ultrasonically treated. During the ultrasonic process, the alkane chain of sodium cocoyl amphoacetate will be embedded into the cavity of β - cyclodextrin. Thereafter, lactic acid is added and heated and stirred. During the heating and stirring process, one carboxyl group of lactic acid will combine with the amino group in aminocyclodextrin, and the other hydroxyl group of lactic acid is easy to form a hydrogen bond with the hydroxyl group in sodium cocoyl amphoacetate or water, making the alkane chain embedded in the cavity of β - cyclodextrin not easy to escape, effectively improving the hydrophilicity of the inclusion material and at the same time improving the cross - linking degree of sodium cocoyl amphoacetate. Then, by mixing and stirring with capryloyl / capryl amidopropyl betaine, sodium methyl cocoyl taurate, and rhamnolipid, the prepared surfactant complex can effectively improve its viscosity and stability. Detailed Embodiments

[0020] The following examples are for further understanding of the present invention, and are not limited to the described optimal implementation mode, and do not constitute a limitation to the protection scope of the present invention.

[0021] For the experimental steps or conditions not specified in the following implementation modes of the present invention, they can be implemented according to the conventional experimental steps and conditions adopted in the existing literature in this field. For the reagents or instruments whose manufacturers are not specified, they are all conventional reagents or instruments that can be obtained through commercial purchase.

[0022] In the following examples and comparative examples, the amino cyclodextrin used has a CAS number of 29390-67-8 and is purchased from Shanghai Yuanye Bio-Technology Co., Ltd.; sodium cocoyl amphoacetate has a CAS number of 68334-21-4 and is manufactured by Foshan Hede New Materials Co., Ltd.; capryloyl / caprylyl amidopropyl betaine is purchased from Guangzhou Hefu Chemical Technology Co., Ltd.; sodium methyl cocoyl taurate has a CAS number of 12765-39-8 and is manufactured by Foshan Hede New Materials Co., Ltd.; rhamnolipid has a CAS number of 869062-42-0 and is purchased from Guangzhou Hefu Chemical Technology Co., Ltd.

[0023] Example 1

[0024] This example provides a preparation method of a surfactant complex, which includes the following steps:

[0025] Mix 5 g of amino cyclodextrin, 25 g of sodium cocoyl amphoacetate and 59.6 g of water, and after mixing, perform ultrasonic treatment. The ultrasonic temperature is 50 °C, the ultrasonic frequency is 100 KHZ, and the ultrasonic time is 90 min. After the ultrasonic treatment, add 0.4 g of lactic acid to the mixed solution, heat and stir. The heating and stirring temperature is 70 °C, the heating and stirring time is 30 min, and the heating and stirring rate is 500 r / min. After the heating and stirring, cool down to room temperature, and then add 4 g of capryloyl / caprylyl amidopropyl betaine, 3 g of sodium methyl cocoyl taurate and 3 g of rhamnolipid, and stir and mix at 55 °C for 1.0 h to obtain the surfactant complex.

[0026] Example 2

[0027] This example provides a preparation method of a surfactant complex, which includes the following steps:

[0028] Mix 7 g of aminocyclodextrin, 25 g of sodium cocoyl amphoacetate and 55 g of water. After mixing, perform ultrasonic treatment. The ultrasonic temperature is 50 °C, the ultrasonic frequency is 150 KHZ, and the ultrasonic time is 100 min. After the ultrasonic treatment, add 0.6 g of lactic acid to the mixed solution, heat and stir. The heating and stirring temperature is 75 °C, the heating and stirring time is 30 min, and the heating and stirring rate is 500 r / min. After the heating and stirring, cool down to room temperature, and then add 4 g of capryloyl / capricyl aminopropyl betaine, 4 g of sodium methyl cocoyl taurate and 4 g of rhamnolipid, and stir and mix at 55 °C for 1.0 h to obtain the surfactant complex.

[0029] Example 3

[0030] This example provides a method for preparing a surfactant complex, which includes the following steps:

[0031] Mix 9 g of aminocyclodextrin, 25 g of sodium cocoyl amphoacetate and 55 g of water. After mixing, perform ultrasonic treatment. The ultrasonic temperature is 50 °C, the ultrasonic frequency is 120 KHZ, and the ultrasonic time is 100 min. After the ultrasonic treatment, add 0.8 g of lactic acid to the mixed solution, heat and stir. The heating and stirring temperature is 75 °C, the heating and stirring time is 30 min, and the heating and stirring rate is 500 r / min. After the heating and stirring, cool down to room temperature, and then add 6 g of capryloyl / capricyl aminopropyl betaine, 3 g of sodium methyl cocoyl taurate and 4 g of rhamnolipid, and stir and mix at 55 °C for 1.0 h to obtain the surfactant complex.

[0032] Example 4

[0033] This example provides a method for preparing a surfactant complex, which includes the following steps:

[0034] Mix 5 g of aminocyclodextrin, 26 g of sodium cocoyl amphoacetate and 60 g of water. After mixing, perform ultrasonic treatment. The ultrasonic temperature is 50 °C, the ultrasonic frequency is 120 KHZ, and the ultrasonic time is 100 min. After the ultrasonic treatment, add 0.6 g of lactic acid to the mixed solution, heat and stir. The heating and stirring temperature is 70 °C, the heating and stirring time is 30 min, and the heating and stirring rate is 500 r / min. After the heating and stirring, cool down to room temperature, and then add 5 g of capryloyl / capricyl aminopropyl betaine, 3 g of sodium methyl cocoyl taurate and 4 g of rhamnolipid, and stir and mix at 60 °C for 2.0 h to obtain the surfactant complex.

[0035] Comparative Example 1

[0036] This comparative example provides a method for preparing a surfactant complex, which includes the following steps:

[0037] Mix 25 g of sodium cocoyl amphoacetate and 64.6 g of water. After mixing, perform ultrasonic treatment. The ultrasonic temperature is 50 °C, the ultrasonic frequency is 100 KHZ, and the ultrasonic time is 90 min. After the ultrasonic treatment, add 0.4 g of lactic acid to the mixture, heat and stir. The heating and stirring temperature is 70 °C, the heating and stirring time is 30 min, and the heating and stirring rate is 500 r / min. After the heating and stirring is completed, cool down to room temperature, and then add 4 g of capryloyl / capryl amidopropyl betaine, 3 g of sodium methyl cocoyl taurate, and 3 g of rhamnolipid, and stir and mix at 55 °C for 1.0 h to obtain the surfactant complex.

[0038] Comparative Example 2

[0039] This comparative example provides a method for preparing a surfactant complex, which includes the following steps:

[0040] Mix 5 g of amino cyclodextrin, 25 g of sodium cocoyl amphoacetate, 0.4 g of lactic acid, and 59.6 g of water. After mixing, perform ultrasonic treatment. The ultrasonic temperature is 50 °C, the ultrasonic frequency is 100 KHZ, and the ultrasonic time is 90 min. After the ultrasonic treatment, heat and stir. The heating and stirring temperature is 70 °C, the heating and stirring time is 30 min, and the heating and stirring rate is 500 r / min. After the heating and stirring is completed, cool down to room temperature, and then add 4 g of capryloyl / capryl amidopropyl betaine, 3 g of sodium methyl cocoyl taurate, and 3 g of rhamnolipid, and stir and mix at 55 °C for 1.0 h to obtain the surfactant complex.

[0041] Test Example 1

[0042] Keep the surfactant complexes prepared in the above examples and comparative examples at a constant temperature of 25 °C for 24 h, and then measure their viscosities using a Brookfield viscometer under the same conditions. Record the viscosities of the surfactant complexes at 25 °C and observe whether their appearances are transparent. The test results are shown in Table 1.

[0043] Table 1

[0044]

[0045] Test Example 2

[0046] Keep the surfactant complexes prepared in the above examples and comparative examples at a constant temperature of 48 °C for 3 months, and observe whether they show stratification or turbidity after 3 months. The test results are shown in Table 2.

[0047] Table 2

[0048]

[0049] Obviously, for those of ordinary skill in the art, other variations can be made based on the above embodiments, and the obvious variations thus brought about are still within the protection scope of the present invention.

Claims

1. A method for preparing a surfactant complex, characterized in that, It includes the following steps: Mix amino cyclodextrin, sodium cocoyl amphoacetate and water, and perform ultrasonic treatment after mixing. After the ultrasonic treatment ends, add lactic acid to the mixed solution, heat and stir. After the heating and stirring end, cool down to room temperature, and then add capryloyl / decoyl aminopropyl betaine, sodium methyl cocoyl taurate and glycolipid, and stir and mix to obtain the surfactant complex; The mass ratio of the amino cyclodextrin, sodium cocoyl amphoacetate and water is (3-7):(20-30):(50-70); the mass ratio of the amino cyclodextrin and lactic acid is (4-8):(0.2-1); the mass ratio of the sodium cocoyl amphoacetate, capryloyl / decoyl aminopropyl betaine, sodium methyl cocoyl taurate and glycolipid is (20-30):(3-7):(2-5):(2-5); In the ultrasonic treatment, the ultrasonic temperature is 45-50 °C, the ultrasonic frequency is 100-150 KHZ, and the ultrasonic time is 60-120 min; the heating and stirring temperature is 60-80 °C, the heating and stirring time is 20-60 min, and the heating and stirring rate is 400-800 r / min; the stirring and mixing temperature is 50-60 °C, and the stirring and mixing time is 0.5-3 h; The glycolipid is rhamnolipid.

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