A functional dressing containing inorganic silicate for promoting rapid wound healing

Abstract

The present invention belongs to the technical field of wound bioactive dressings, and specifically relates to a functional dressing containing inorganic silicates that promotes rapid healing of wounds, and a preparation method and application thereof. The functional dressing contains inorganic silicate particles and natural plant extracts, wherein the inorganic silicate particles are composed of Na2O, CaO, P2O5 and SiO2, and have a particle size of 30-50 μm, and the natural plant extracts are selected from one or more of the following: lithospermum officinale extract, salvia miltiorrhiza extract or tamarisk bark extract. The functional dressing containing inorganic silicates of the present invention can promote rapid healing and repair of wounds, is easy to use, has good stability and low irritation, and can be used on superficial wounds. In addition to being used on superficial wounds, it is also particularly suitable for treating soft tissue ulcers or long-term erosions such as diabetic ulcers, diabetic foot, bedsores, sinus tracts or fat liquefaction wounds.

Description

Technical Field

[0001] The invention belongs to the technical field of bioactive wound dressings, and specifically relates to a functional dressing containing inorganic silicate for promoting rapid wound healing, and a preparation method and application thereof. Background Art

[0002] Previous studies have shown that inorganic silicate particles can form a protective film on the surface of wounds and act as a physical barrier. Therefore, they can be used to care for non-chronic wounds such as small superficial abrasions and cuts and the surrounding skin. Inorganic silicate particles are silicate glass composed of basic components such as Na2O, CaO, P2O5 and SiO2. Inorganic silicate particles can activate gene expression related to wound healing, promote the proliferation and differentiation of fibroblasts, accelerate angiogenesis, promote the growth of granulation tissue, promote tissue repair and regeneration, and thus promote wound healing. At present, inorganic silicate particles are considered to be good biomaterials that can be used in the field of wound repair. This restorative material is compatible with human tissue and promotes wound healing. In addition, it has good hygroscopicity and antibacterial properties, which can effectively absorb wound secretions and prevent infection.

[0003] However, the effect of inorganic silicate particles alone on deep skin trauma is not ideal and takes a long time to take effect. The treatment of deep skin trauma such as burns, scalds, soft tissue ulcers and long-term erosion is a clinical problem. Severe patients can only be treated by hospitalization, daily wound cleaning, disinfection and dressing changes, which makes the operation not only cumbersome but also extremely painful for patients. In addition, some currently commercialized dressings containing inorganic silicate particles are highly irritating after being used on the wound surface, resulting in poor patient compliance.

[0004] In view of this, in order to solve the defects and shortcomings of the functional dressings containing inorganic silicates in the prior art, the present invention provides a novel functional dressing containing inorganic silicate particles and natural plant extracts. Summary of the invention

[0005] The purpose of the present invention is to solve the deficiencies of the prior art and provide a novel functional dressing containing inorganic silicates that promotes rapid wound healing, as well as a preparation method and application thereof. The functional dressing of the present invention comprises inorganic silicate particles and a specific type of natural plant extract as active ingredients in a specific dosage ratio, and is prepared by formula optimization to obtain a preparation, thereby obtaining a wound care product with excellent biological properties and physicochemical properties. In addition to being used on superficial wounds, it is also particularly suitable for treating soft tissue ulcers or long-term erosions such as diabetic ulcers, diabetic foot, bedsores, sinus tracts or fat liquefaction wounds.

[0006] To achieve the purpose of the present invention, the present invention adopts the following technical solutions:

[0007] In the first aspect, the present invention provides a functional dressing comprising inorganic silicates for promoting rapid wound healing, wherein the functional dressing comprises inorganic silicate particles and natural plant extracts, wherein the inorganic silicate particles are composed of Na2O, CaO, P2O5 and SiO2, and have a particle size of 30-50 μm, and the natural plant extract is selected from one or more of the following: lithospermum officinale extract, salvia miltiorrhiza extract or Tamarix salix bark extract.

[0008] Preferably, the particle size of the inorganic silicate particles is 40 μm.

[0009] As an optional manner, in the above functional dressing, the composition of the inorganic silicate particles is 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, in weight percentage.

[0010] As an optional manner, in the above functional dressing, the natural plant extracts are Lithospermum officinale extract, Salvia miltiorrhiza extract and Tamarix salviae bark extract.

[0011] Preferably, the weight ratio of Lithospermum officinale extract: Salvia miltiorrhiza extract: Tamarix chinensis bark extract is in the range of 1-5:1-5:1-5.

[0012] More preferably, the weight ratio of Lithospermum officinale extract:Salvia miltiorrhiza extract:Tamarix chinensis bark extract is in the range of 5:3:2.

[0013] In addition, as an optional mode, the extract of Lithospermum erythrorhizon is shikonin, the extract of Salvia miltiorrhiza is tanshinone, and the extract of Tamarix chinensis bark is tamarixanthin.

[0014] The natural plant extract used in the present invention can be extracted and separated from plants containing the active ingredient by conventional biological purification methods, or can be purchased from commercial products.

[0015] As an optional manner, in the above functional dressing, the functional dressing further comprises a propellant, and the propellant is selected from one or more of the following: dichlorodifluoromethane, trichloromonofluoromethane or tetrafluoroethane.

[0016] Preferably, the propellant is tetrafluoroethane.

[0017] As an optional manner, in the above functional dressing, the weight ratio of the inorganic silicate particles: the natural plant extract: the propellant is in the range of 1-10: 1-10: 1-10.

[0018] As an optional manner, in the above functional dressing, the weight ratio of the inorganic silicate particles: the natural plant extract: the propellant is in the range of 10:1:9.

[0019] In a second aspect, the present invention provides a method for preparing the functional dressing according to the first aspect, comprising the following steps:

[0020] (1) preparing inorganic silicate particles by a melting method, weighing Na2O, CaO, P2O5 and SiO2 according to appropriate chemical compositions, mixing them and melting them at 1300-1600°C, and then cooling, crushing and sieving to prepare inorganic silicate particles with a particle size of 30-50 μm;

[0021] (2) Weigh the inorganic silicate particles prepared in step (1) and the ultrafine powder of natural plant extract that has been crushed through a 200-mesh sieve according to a weight ratio, mix them thoroughly, and stir for 8-10 minutes at a stirring speed of 200-300 rpm;

[0022] (3) The mixture prepared in step (2) is packaged in a pressure-resistant container, which is sealed after being equipped with a valve system, and a propellant is poured into the pressure-resistant container so that the pressure reaches 0.3-0.6 MPa, and an air-tightness check is performed, followed by cobalt-60 irradiation sterilization to obtain the functional dressing.

[0023] Preferably, the method for preparing the functional dressing comprises the following steps:

[0024] (1) preparing inorganic silicate particles by a melting method, weighing Na2O, CaO, P2O5 and SiO2 in a ratio of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, mixing and melting at 1500°C, cooling, crushing and sieving to prepare inorganic silicate particles with a particle size of 40 μm;

[0025] (2) weighing the inorganic silicate particles prepared in step (1) and the natural plant extract ultrafine powder crushed through a 200-mesh sieve according to a weight ratio, mixing them thoroughly, and stirring for 10 minutes at a stirring speed of 250 rpm;

[0026] (3) The mixture prepared in step (2) is packaged in a pressure-resistant container, which is sealed after being equipped with a valve system, and a propellant is poured into the pressure-resistant container so that the pressure reaches 0.3-0.6 MPa, and an air-tightness check is performed, followed by cobalt-60 irradiation sterilization to obtain the functional dressing.

[0027] In a third aspect, the present invention provides use of the functional dressing described in the first aspect or the functional dressing prepared by the preparation method described in the second aspect in preparing a drug for promoting rapid wound healing and repair.

[0028] As an optional mode, in the above use, the wound surface is a superficial wound surface.

[0029] As an optional mode, in the above use, the wound surface is a burn, scald, soft tissue ulcer or long-term erosion.

[0030] As an optional mode, in the above use, the wound surface is a diabetic ulcer, diabetic foot, bedsore, sinus tract or fat liquefaction wound.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] (1) The functional dressing of the present invention comprises inorganic silicate particles and a specific type of natural plant extract as active ingredients in a specific dosage ratio, and is prepared by formula optimization to obtain a preparation, thereby obtaining a wound care product with excellent biological properties and physicochemical properties. In addition to being used on superficial wounds, it is also particularly suitable for treating soft tissue ulcers or long-term erosions such as diabetic ulcers, diabetic foot, bedsores, sinus tracts or fat liquefaction wounds.

[0033] (2) The functional dressing prepared by the method of the present invention has good stability and dispersibility, and the inorganic silicate particles and natural plant extract ultrafine powder contained therein will not agglomerate.

[0034] (3) The functional dressing of the present invention is easy to use, has little irritation to the wound surface, and the patient does not feel obvious pain on the wound surface after use. The patient compliance is good, and the long-term use is relatively safe. DETAILED DESCRIPTION

[0035] The present invention will be further described with reference to specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the scope of the present invention.

[0036] If no specific techniques or conditions are specified in the examples, the techniques or conditions described in the literature in the field or the product instructions are used. If no manufacturer is specified for the reagents or instruments used, they are all conventional products that can be purchased through regular channels.

[0037] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples are commercially available products unless otherwise specified.

[0038] Preparation Example:

[0039] Embodiment 1:

[0040] A functional dressing containing inorganic silicate for promoting rapid wound healing. The functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant. The weight ratio of inorganic silicate particles: natural plant extract: propellant is 10:1:9. The inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and have a particle size of 40μm. The natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract. The weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is 5:3:2. The lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is tamarix flavonoids, and the propellant is tetrafluoroethane.

[0041] The preparation method of the functional dressing comprises the following steps:

[0042] (1) preparing inorganic silicate particles by a melting method, weighing Na2O, CaO, P2O5 and SiO2 in a ratio of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, mixing and melting at 1500°C, cooling, crushing and sieving to prepare inorganic silicate particles with a particle size of 40 μm;

[0043] (2) weighing the inorganic silicate particles prepared in step (1) and the natural plant extract ultrafine powder crushed through a 200-mesh sieve according to a weight ratio, mixing them thoroughly, and stirring for 10 minutes at a stirring speed of 250 rpm;

[0044] (3) The mixture prepared in step (2) is packaged in a pressure-resistant container, which is sealed after being equipped with a valve system, and a propellant is poured into the pressure-resistant container so that the pressure reaches 0.3-0.6 MPa, and an air-tightness check is performed, followed by cobalt-60 irradiation sterilization to obtain the functional dressing.

[0045] Embodiment 2:

[0046] A functional dressing containing inorganic silicate for promoting rapid wound healing. The functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant. The weight ratio of inorganic silicate particles: natural plant extract: propellant is 10:2:8. The inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and have a particle size of 40μm. The natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract. The weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is 5:3:2. The lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is tamarix flavonoids, and the propellant is tetrafluoroethane.

[0047] The preparation method of the functional dressing is the same as that of Example 1.

[0048] Embodiment 3:

[0049] A functional dressing containing inorganic silicate for promoting rapid wound healing. The functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant. The weight ratio of inorganic silicate particles: natural plant extract: propellant is 10:1:9. The inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and have a particle size of 40μm. The natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract. The weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is 5:4:1. The lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is tamarix flavonoids, and the propellant is tetrafluoroethane.

[0050] The preparation method of the functional dressing is the same as that of Example 1.

[0051] Comparative Example 1:

[0052] A functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant, wherein the weight ratio of inorganic silicate particles: natural plant extract: propellant is 10:1:9, the inorganic silicate particles are composed of 24.5wt% Na2O, 24.5wt% CaO, 6wt% P205 and 45wt% SiO2, and the particle size is 40μm, the natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract, the weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is 5:3:2, the lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is tamarix flavonoids, and the propellant is tetrafluoroethane.

[0053] The preparation method of the functional dressing comprises the following steps:

[0054] (1) preparing inorganic silicate particles by a melting method, weighing Na2O, CaO, P2O5 and SiO2 in a ratio of 24.5wt% Na2O, 24.5wt% CaO, 6wt% P2O5 and 45wt% SiO2, mixing and melting at 1500°C, cooling, crushing and sieving to prepare inorganic silicate particles with a particle size of 40 μm;

[0055] (2) weighing the inorganic silicate particles prepared in step (1) and the natural plant extract ultrafine powder crushed through a 200-mesh sieve according to a weight ratio, mixing them thoroughly, and stirring for 10 minutes at a stirring speed of 250 rpm;

[0056] (3) The mixture prepared in step (2) is packaged in a pressure-resistant container, which is sealed after being equipped with a valve system, and a propellant is poured into the pressure-resistant container so that the pressure reaches 0.3-0.6 MPa, and an air-tightness check is performed, followed by cobalt-60 irradiation sterilization to obtain the functional dressing.

[0057] Comparative Example 2:

[0058] A functional dressing containing inorganic silicate, wherein the functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant, the weight ratio of inorganic silicate particles: natural plant extract: propellant is in the range of 10:1:9, the inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and the particle size is 40μm, the natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract, the weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is in the range of 5:3:2, the lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is quercetin, and the propellant is tetrafluoroethane.

[0059] The preparation method of the functional dressing is the same as that of Example 1.

[0060] Comparative Example 3:

[0061] A functional dressing containing inorganic silicate, wherein the functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant, the weight ratio of inorganic silicate particles: natural plant extracts: propellant is in the range of 10:1:9, the inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and the particle size is 40μm, the natural plant extracts are lithospermum extract and salvia miltiorrhiza extract, the weight ratio of lithospermum extract: salvia miltiorrhiza extract is in the range of 1:1, the lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, and the propellant is tetrafluoroethane.

[0062] The preparation method of the functional dressing is the same as that of Example 1.

[0063] Comparative Example 4:

[0064] A functional dressing containing inorganic silicate, wherein the functional dressing is made of inorganic silicate particles, natural plant extracts and a propellant, the weight ratio of inorganic silicate particles: natural plant extract: propellant is in the range of 10:1:9, the inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and the particle size is 40μm, the natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract, the weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is in the range of 5:3:2, the lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is tamarixanthin, and the propellant is tetrafluoroethane.

[0065] The preparation method of the functional dressing comprises the following steps:

[0066] (1) preparing inorganic silicate particles by a melting method, weighing Na2O, CaO, P2O5 and SiO2 in a ratio of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, mixing and melting at 1500°C, cooling, crushing and sieving to prepare inorganic silicate particles with a particle size of 40 μm;

[0067] (2) weighing the inorganic silicate particles prepared in step (1) and the fine powder of the natural plant extract crushed through a 40-mesh sieve according to the weight ratio, mixing them thoroughly, and stirring for 10 minutes at a stirring speed of 250 rpm;

[0068] (3) The mixture prepared in step (2) is packaged in a pressure-resistant container, which is sealed after being equipped with a valve system, and a propellant is poured into the pressure-resistant container so that the pressure reaches 0.3-0.6 MPa, and an air-tightness check is performed, followed by cobalt-60 irradiation sterilization to obtain the functional dressing.

[0069] Effect embodiment:

[0070] It is mainly used to examine the effect of the functional dressing containing inorganic silicate of the present invention on promoting rapid healing and repair of wound surface.

[0071] 1. Experimental methods:

[0072] 64 male Kunming mice aged 6-8 weeks weighing 18-22 g were selected as experimental animals. On day 0, the mice were anesthetized and the epidermis, dermis and subcutaneous connective tissue were removed with a scalpel under sterile conditions. A wound with a diameter of 2 cm was created on the back of each mouse. The mice were randomly divided into 8 groups, 8 in each group.

[0073] The mice in the model group were covered with sterile gauze only and fixed with a sterile elastic bandage, which was changed every 2 days. From day 0, the mice in Example 1-3 and Comparative Example 1-4 were directly and evenly applied with an equal amount of the prepared functional dressing on the wound surface (about 1 g / mouse), covered with sterile gauze, and fixed with a sterile elastic bandage, which was changed every 2 days, and the wound repair and healing was observed on the dressing change day.

[0074] 2. Wound repair and healing evaluation method:

[0075] A digital camera was used to record wound repair and granulation tissue growth on each dressing change day. The digital photos were imported into a computer and the wound area was calculated using the image analysis software Image-Pro plus. The average wound repair and healing percentages of each group on the 2nd and 10th days were calculated.

[0076] The calculation formula of wound repair and healing percentage = (A0-At) / A0 x 100%, where A0 is the initial wound area and At is the wound area at time point t.

[0077] In addition, it is necessary to calculate the average healing time of each group, that is, the time required from the start of surgery to the complete coverage of the wound by the epidermis.

[0078] 3. Statistical analysis:

[0079] The data were expressed as mean ± standard deviation, and the results were analyzed using SPSS 20.0 statistical software. The t-test was used to compare the two groups, with p < 0.05 indicating a statistically significant difference, and p < 0.01 indicating a statistically significant difference.

[0080] 4. Experimental results:

[0081] It can be seen from Table 1 that on the second day, the wound healing % of the Example 1-3 and Comparative Example 1-4 groups were higher than that of the model group, but the difference was not significant.

[0082] For the average wound repair and healing % on the 10th day, the average wound repair and healing % of Example 1, Example 2, Example 3, Comparative Example 1 and Comparative Example 4 groups were significantly different from those of the model group (*p < 0.05, **p < 0.01). These results show that the efficacy of the functional dressing of the present invention is closely related to the dosage ratio of each component therein, and the functional dressing of Example 1 group has the best effect in promoting rapid healing and repair of the wound. In addition, it can be seen from the experimental results of each comparative example group that the dosage ratio of each group of components in the inorganic silicate particles, the type of natural plant extract (for example, replacing tamarix with quercetin with a similar chemical structure, or removing tamarix from the natural plant extract, the efficacy of the functional dressing will be significantly reduced, see Comparative Example 2 and Comparative Example 4) and the crushing mesh of the natural plant extract powder are closely related to the efficacy of the functional dressing of the present invention.

[0083] In terms of average healing time, a change trend consistent with the average wound repair and healing % on the 10th day was also observed, that is, the average healing time of Example 1 Group, Example 2 Group, Example 3 Group and Comparative Example 4 Group were significantly different from the model group (*p<0.05, **p<0.01).

[0084] Table 1: Results of the functional dressing containing inorganic silicate in the present invention promoting rapid wound healing and repair (mean ± standard deviation, n = 8)

[0085]

[0086] Note: Compared with the model group, *p<0.05, **p<0.01.

[0087] 5. Experimental conclusion:

[0088] The functional dressing of the present invention comprises inorganic silicate particles and a specific type of natural plant extract as active ingredients in a specific dosage ratio, and is prepared by formula optimization to obtain a preparation, thereby obtaining a wound care product with excellent biological properties and physicochemical properties. In addition to being used on superficial wounds, it is also particularly suitable for treating soft tissue ulcers or long-term erosions such as diabetic ulcers, diabetic foot, bedsores, sinus tracts or fat liquefaction wounds.

[0089] In addition, it can be observed during the experiment that after the functional dressing of the present invention is applied to the wounds of mice, it has less irritation to the wound surface, the mice do not feel obvious pain, the experimental animals have good compliance, and the long-term use is relatively safe.

[0090] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A functional dressing comprising inorganic silicate for promoting rapid wound healing, characterized in that: The functional dressing is made of inorganic silicate particles, natural plant extracts and propellants. The weight ratio of inorganic silicate particles: natural plant extracts: propellants is in the range of 10:1:

9. The inorganic silicate particles are composed of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, and the particle size is 40μm. The natural plant extracts are lithospermum extract, salvia miltiorrhiza extract and Tamarix salviae bark extract. The weight ratio of lithospermum extract: salvia miltiorrhiza extract: Tamarix salviae bark extract is in the range of 5:3:

2. The lithospermum extract is shikonin, the salvia miltiorrhiza extract is tanshinone, the Tamarix salviae bark extract is tamarix flavonoids, and the propellant is tetrafluoroethane.

2. The method for preparing the functional dressing according to claim 1, characterized in that: The following steps are involved: (1) preparing inorganic silicate particles by a melting method, weighing Na2O, CaO, P2O5 and SiO2 in a ratio of 25wt% Na2O, 25wt% CaO, 5wt% P2O5 and 45wt% SiO2, mixing and melting at 1500°C, cooling, crushing and sieving to prepare inorganic silicate particles with a particle size of 40 μm; (2) weighing the inorganic silicate particles prepared in step (1) and the natural plant extract ultrafine powder crushed through a 200-mesh sieve according to a weight ratio, mixing them thoroughly, and stirring for 10 minutes at a stirring speed of 250 rpm; (3) The mixture prepared in step (2) is packaged in a pressure-resistant container, which is sealed after being equipped with a valve system, and a propellant is poured into the pressure-resistant container so that the pressure reaches 0.3-0.6 MPa, and an air-tightness check is performed, followed by cobalt-60 irradiation sterilization to obtain the functional dressing.

3. Use of the functional dressing according to claim 1 or the functional dressing prepared by the preparation method according to claim 2 in the preparation of a drug for promoting rapid healing and repair of wounds.

4. The use according to claim 3, characterized in that: The wound surface is a superficial wound surface.

5. The use according to claim 3, characterized in that: The wound surface is burns, scalds, soft tissue ulcers or long-term erosions.

6. The use according to claim 5, characterized in that: The wound surface is a diabetic ulcer, diabetic foot, bedsore, sinus tract or fat liquefaction wound.

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