Microneedle coating device

Abstract

The present invention discloses a microneedle scraping device, comprising a liquid injection cover with a sealed liquid injection chamber, a scraping cover with a semi-enclosed scraping chamber, a scraper assembly, a liquid injection unit connected to the liquid injection chamber to inject liquid, and a vacuum suction unit connected to the scraping chamber to evacuate the liquid. The open end of the scraping cover covers the microneedle forming mold, and the scraping cover and the microneedle forming mold define a closed scraping chamber. A connecting channel is provided between the liquid injection chamber and the scraping chamber. The scraper assembly is disposed within the scraping cover and abuts the microneedle forming mold. The sidewall of the scraper assembly is in contact with the inner sidewall of the scraping chamber. The scraper assembly is configured to move relative to the microneedle forming mold to block or open the connecting channel, and the scraper assembly recovers excess microneedle forming liquid into the liquid injection chamber when scraping back. The microneedle scraping device of the present invention can quickly fill the microneedle forming chamber, improving production efficiency. The scraper assembly can also return excess microneedle forming liquid to the liquid injection chamber, avoiding liquid waste.

Description

Technical Field

[0001] The present invention belongs to the field of microneedle technology, and in particular relates to a microneedle scraping device. Background Art

[0002] Microneedle drug delivery is a new method of drug delivery. It mainly forms multiple microneedles on a substrate. The diameter of the microneedles is only one tenth of a hair. The microneedles are inserted into the skin to deliver the drug, which can greatly reduce the pain during the drug delivery process.

[0003] The preparation process of soluble microneedles mainly adopts mold injection. The specific preparation process is to inject the corresponding drugs and adjuvants into the mold, and after drying, solidification and forming, demolding is carried out to collect the prepared microneedles. In the microneedle preparation process, during the filling and scraping stage, the excess microneedle filling liquid is mainly applied to the surface of the microneedle forming mold, and the microneedles are filled into the microneedle forming cavity of the microneedle forming mold using a scraping plate. After the scraping is completed, the excess microneedle forming liquid is directly scraped off by the scraper and cannot be recycled, resulting in waste of microneedle forming liquid. In addition, the filling efficiency is low because the microneedle forming cavity of the microneedle forming mold is filled only by the gravity of the solution itself, and the quality uniformity of the microneedle finished product is difficult to guarantee. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a microneedle scraping device.

[0005] The technical solution adopted by the present invention to solve the technical problem is as follows: providing a microneedle scraping device, comprising a liquid injection cover having a sealed liquid injection cavity, a scraping cover having a semi-enclosed scraping cavity, a scraper assembly disposed in the scraping cover, a liquid injection unit communicating with the liquid injection cavity to inject microneedle forming liquid into the liquid injection cavity, and a vacuum suction unit communicating with the scraping cavity to evacuate the scraping cavity;

[0006] The open end of the scraping cover covers the forming surface of the microneedle forming mold, and the scraping cover and the microneedle forming mold define a closed scraping cavity;

[0007] The injection chamber is connected to the scraping chamber, the scraper assembly abuts against the molding surface of the microneedle forming mold, the side wall of the scraper assembly fits with the inner wall of the scraping chamber, the scraper assembly is configured to be movable relative to the microneedle forming mold to block or open the connecting channel, and the scraper assembly recovers excess microneedle forming liquid into the injection chamber when scraping back.

[0008] Furthermore, it is preferred that the liquid injection cover and the scraping cover are arranged side by side, a through hole is opened between the liquid injection cover and the scraping cover, the through hole forms the communicating channel, and the through hole is arranged at the bottom of the side wall of the liquid injection cover.

[0009] Furthermore, it is preferred that the position of the liquid injection cover is higher than the position of the scraping cover; and / or the bottom of the liquid injection chamber is an inclined surface inclined downward toward the scraping chamber; and / or the connecting channel is an inclined channel inclined downward from the liquid injection chamber toward the scraping chamber.

[0010] Furthermore, it is preferred that the scraping cover is provided with a vacuum suction port for connecting to a vacuum suction unit.

[0011] Furthermore, the thickness of the scraper assembly is preferably greater than or equal to the aperture of the vacuum suction port. During the movement of the scraper assembly, the front and rear spaces within the coating cover, which are dynamically divided by the scraper assembly, remain relatively isolated. That is, even if the scraper assembly passes through the vacuum suction port, the two spaces will not be connected by gas due to the gap formed between the vacuum suction port and the scraper assembly due to the timely sealing of the scraper assembly.

[0012] Furthermore, the vacuum suction port is preferably disposed on the top wall or side wall of the squeegee shield, away from the liquid injection shield. During movement of the squeegee assembly, the interior of the squeegee shield is dynamically divided into two relatively isolated spaces by the squeegee assembly. Specifically, the space away from the communication channel remains isolated from the other side, preventing gas communication between this space and the communication channel or liquid injection shield, which could result in premature vacuum breakage of the microneedle mold before it comes into contact with liquid.

[0013] Furthermore, it is preferred that the vacuum suction unit remains in a working state before the scraper assembly scrapes back, and continues to vacuum the scraping cover.

[0014] Furthermore, it is preferred that the scraping device further includes an auxiliary pressurizing unit, and the auxiliary pressurizing unit is configured to apply pressure to the scraping mask toward the microneedle forming mold.

[0015] Furthermore, it is preferred that the auxiliary pressurizing unit is at least one of a hydraulic cylinder, a pneumatic press, a screw press, and a mechanical press.

[0016] Furthermore, it is preferred that the liquid injection cover is connected to a liquid injection tube, and the other end of the liquid injection tube is connected to the liquid injection unit.

[0017] Furthermore, it is preferred that the liquid injection unit includes a flow regulating valve, and the flow regulating valve is arranged between the liquid injection unit and the liquid injection cavity.

[0018] Furthermore, it is preferred that a flow regulating valve is provided on the liquid injection pipe.

[0019] Furthermore, it is preferred that the scraping cover is connected to a vacuum tube, and the other end of the vacuum tube is connected to a vacuum suction unit.

[0020] Furthermore, preferably, the vacuum suction unit further includes an air pressure regulating valve, and the air pressure regulating valve is arranged between the vacuum suction unit and the coating chamber.

[0021] Furthermore, the vacuum tube is connected to the air pressure regulating valve.

[0022] Furthermore, it is preferred that the scraper assembly includes a scraper and a push-pull rod connected to one side of the scraper, one end of the push-pull rod passes through the side wall of the scraping cover so that the push-pull rod can drive the scraper located in the scraping chamber to move; the scraper side wall is in close contact with the inner wall of the scraping chamber, the bottom of the scraper is in contact with the molding surface of the microneedle molding mold, the scraper is configured to be movable relative to the microneedle molding mold to block or open the connecting channel, and the scraper pushes excess microneedle molding liquid back into the injection chamber when scraping back; and / or, the microneedle scraping device also includes a moving component located outside the scraping chamber, the moving component is connected to the push-pull rod so that the moving component can drive the push-pull rod to move.

[0023] Furthermore, it is preferred that the moving assembly includes a transmission member and a moving drive member, the transmission member is connected to the push-pull rod, and the moving drive member is drivingly connected to the transmission member to drive the transmission member to move.

[0024] Furthermore, preferably, the scraper assembly also includes a flexible scraping coating layer surrounding the outer edge of the scraper; or, the scraper is a flexible scraper, and the scraper assembly also includes a fixing plate at least attached to the flexible scraper on the side away from the injection chamber, and the fixing plate is connected to the push-pull rod.

[0025] Furthermore, it is preferred that the width of the scraper is the same as the width of the scraping cavity; or, the scraper is a flexible scraper, and the width of the flexible scraper is equal to or slightly wider than the width of the scraping cavity; the sum of the widths of the scraper and the flexible scraping layer is equal to or slightly wider than the width of the scraping cavity.

[0026] Furthermore, it is preferred that a positioning groove is provided on the inner wall of the bottom of the scraper cover, and the positioning groove matches the microneedle forming mold.

[0027] Furthermore, preferably, a sealing ring is provided in the positioning groove.

[0028] The implementation of the present invention has at least the following beneficial effects: according to the microneedle scraping device provided by the present invention, when preparing microneedles, the vacuum cover can be placed on the molding surface of the microneedle forming mold, and the scraping cavity is sucked by the vacuum suction unit, so that the gas in the microneedle forming cavity of the microneedle forming mold is extracted, so that a negative pressure environment is formed in the scraping cavity, and the injection cavity is injected with liquid by the injection unit, and the scraper assembly is driven to move in a direction away from the injection cavity to open the communication channel between the injection cavity and the scraping cavity. Under the action of the air pressure difference, the microneedle forming liquid in the injection cavity flows to the scraping cavity and covers the molding surface of the microneedle forming mold. The negative pressure environment in the microneedle forming cavity of the microneedle forming mold prompts the liquid to enter and fill the microneedle forming cavity. This molding method can quickly fill the microneedle forming cavity and improve production efficiency. On the other hand, after the preliminary filling is completed, the scraper assembly is driven to return and move in a direction close to the injection cavity. The reverse movement of the scraper assembly further assists in scraping and filling, making the distribution more uniform and the filling effect better, thereby improving the uniformity of the quality of the microneedle finished product. The excess liquid is pushed back into the injection chamber by the scraper assembly to achieve the recovery of excess liquid and avoid liquid waste. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is a cross-sectional view of a first embodiment of the microneedle coating device provided by the present invention;

[0030] Figure 2 is a cross-sectional view of a second embodiment of the microneedle coating device provided by the present invention;

[0031] Figure 3 is a cross-sectional view of a third embodiment of the microneedle coating device provided by the present invention;

[0032] Figure 4 is a cross-sectional view of a fourth embodiment of the microneedle coating device provided by the present invention;

[0033] Figure 5 is a cross-sectional view of a fifth embodiment of the microneedle coating device provided by the present invention;

[0034] Figure 6 is a cross-sectional view of a sixth embodiment of the microneedle coating device provided by the present invention;

[0035] Figure 7 It is a cross-sectional view of a seventh embodiment of the microneedle coating device provided by the present invention. DETAILED DESCRIPTION

[0036] In order to make the technical problems, technical solutions and beneficial effects solved by the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0037] In the description of the present invention, numerical ranges are inclusive of the numbers themselves. It should be understood that terms such as "height," "width," "diameter," "cross-sectional area," "top," "bottom," "top," "bottom," "upper," and "upper" are based on the orientations or positional relationships shown in the accompanying drawings and are not to be construed as limiting the present invention. In the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0038] The structure of the microneedle patch embodiment is described with reference to the accompanying drawings. Figure 1-Figure 5 As shown, the present invention provides a microneedle scraping device, comprising a liquid injection cover 10 having a sealed liquid injection chamber 11, a scraping cover 20 having a semi-enclosed scraping chamber 21, a scraper assembly 30 arranged in the scraping cover 20, an injection unit 40 connected to the liquid injection chamber 11 to inject microneedle forming liquid into the liquid injection chamber 11, and a vacuum suction unit 50 connected to the scraping chamber 21 to vacuum the scraping chamber 21.

[0039] Among them, the open end of the scraping cover 20 covers the molding surface of the microneedle molding mold 100, and the scraping cover 20 covers the microneedle molding mold 100 to define a closed scraping cavity 21; the molding mold includes a frame structure and a molding surface embedded in the frame structure, the frame structure is a rigid material, and the molding surface is a flexible material. A plurality of microneedle molding cavities 101 are provided on the molding surface, and the microneedle molding cavity 101 is used for molding microneedles. The microneedle molding liquid is poured into the molding surface and the microneedle molding cavity 101, and the microneedle molding liquid is solidified and molded to obtain a substrate and a plurality of microneedles connected to the substrate, and one side of the substrate is exposed on the surface of the microneedle molding mold.

[0040] A connecting channel 80 is provided between the liquid injection chamber 11 and the scraping chamber 21, and the scraper assembly 30 abuts against the molding surface of the microneedle forming mold 100, and the microneedle forming liquid is scraped and filled into the microneedle forming cavity 101 of the microneedle forming mold 100 by moving the scraper; the side wall of the scraper assembly 30 is in contact with the inner side wall of the scraping chamber 21, and the scraper assembly 30 is configured to be movable relative to the microneedle forming mold 100 to block or open the connecting channel 80, that is, the scraper assembly 30 is arranged perpendicular to the longitudinal direction of the microneedle forming mold 100 and the side edge is in contact with the inner wall of the scraping cover 20, and the scraper assembly 30 is arranged on the side close to the liquid injection chamber 11, and blocks the connecting channel 80 when it is in contact with the connecting channel, and the liquid in the liquid injection cover 10 is retained in the liquid injection chamber 11; the scraper assembly 30 is driven away from the liquid injection chamber After the movement in one side direction of the cavity 11, the connecting channel 80 is opened, and the liquid in the liquid injection cover 10 enters the scraping cavity 21 through the connecting channel 80. Since the microneedle molding cavity 101 of the microneedle molding mold 100 has been evacuated by the vacuum suction unit 50, the air content of the microneedle molding cavity 101 is greatly reduced. At the same time, the vacuum in the scraping cavity 21 is broken, and the liquid can be filled into the microneedle molding cavity 101 under the action of the pressure difference and its own gravity; as the scraper assembly 30 moves to expose the microneedle molding mold 100 at the bottom, the liquid flows and diffuses on the microneedle molding mold while filling into the microneedle molding cavity 101; after all the microneedle molding cavities 101 of the microneedle molding mold 100 are preliminarily filled, the scraper assembly 30 is driven back and moves in the direction close to the liquid injection cavity 11. The reverse movement of the scraper assembly 30 further assists in scraping and filling, making the distribution more uniform and the filling effect better, thereby improving the quality uniformity of the microneedle finished product, and the excess liquid is pushed back into the liquid injection chamber 11 by the scraper assembly 30, thereby recovering the excess liquid and avoiding liquid waste; through the vacuuming of the vacuum suction unit 50 and the scraping of the scraper assembly 30, after the vacuum is broken, the microneedle forming liquid is automatically filled into the microneedle forming chamber 101 under the action of pressure, thereby ensuring the quality uniformity of the microneedle finished product and improving production efficiency; and the microneedle scraping device of the present invention has a simple structure and is easy to clean and maintain.

[0041] The implementation process of the microneedle scraping device of the present invention is as follows: the open end of the scraping cover 20 covers the molding surface of the microneedle forming mold 100, and the scraping cover 20 covers the microneedle forming mold 100 to define a closed scraping chamber 21, and the scraper assembly 30 moves to block the communication channel between the injection chamber 11 and the scraping chamber 21, and the vacuum suction unit 50 is opened to vacuum the sealed scraping chamber 21. When the scraping chamber 21 reaches the target vacuum degree, the vacuum suction unit 50 can be closed, or the vacuum suction unit 50 can be kept in a working state, continuously sucking, and keeping the scraping chamber 21 sealed. At this time, the microneedle forming chamber 101 on the microneedle forming mold 100 has been vacuumed, greatly reducing the air content; the injection unit 40 is opened, and the microneedle forming liquid is injected into the injection chamber 11. When the predetermined amount is injected or filled, the amount of microneedle forming liquid is sufficient to fill the microneedle forming cavity and does not overflow the scraping chamber 21, and the injection is closed. After the scraper assembly 30 is driven to move in a direction away from the liquid injection chamber 11, the connecting channel 80 is opened, and the liquid in the liquid injection cover 10 enters the scraping chamber 21 through the connecting channel 80. Since the microneedle molding chamber 101 of the microneedle molding mold 100 has been evacuated by the vacuum suction unit 50, the air content in the microneedle molding chamber 101 is greatly reduced. At the same time, the vacuum in the scraping chamber 21 is broken, and the liquid can be filled into the microneedle molding chamber 101 under the action of the pressure difference and its own gravity; as the scraper assembly 30 moves to expose the microneedle molding mold 100 at the bottom, the liquid flows and diffuses on the microneedle molding mold while filling into the microneedle molding chamber 101; after all the microneedle molding chambers 101 of the microneedle molding mold 100 are preliminarily filled, the scraper assembly 30 is driven to return, and the scraper assembly 30 is driven to return and move in a direction close to the liquid injection chamber 11. At this time, the scraper assembly 30 scrapes in the opposite direction on the surface of the microneedle forming mold 100, which further assists the scraping and filling, making the liquid distribution more uniform and the filling effect better, thereby improving the quality uniformity of the microneedle finished product. As the scraper assembly 30 scrapes back, not only the filling and scraping of the microneedle is completed efficiently, but also the excess liquid is pushed back to the injection chamber 11, thereby realizing the recovery of excess liquid and avoiding liquid waste.

[0042] In a specific embodiment, the microneedle forming mold 100 covered by the scraping mask 20 includes a single microneedle patch, or may include multiple microneedle patches, thereby improving production efficiency.

[0043] In some preferred embodiments, the liquid injection cover 10 and the scraping cover 20 are arranged side by side to facilitate the liquid in the liquid injection chamber 11 to flow to the scraping chamber 21; a through hole is opened between the liquid injection cover 10 and the scraping cover 20, and the through hole forms a connecting channel 80 between the liquid injection chamber 11 and the scraping chamber 21. The liquid injection cover 10 and the scraping cover 20 are arranged side by side and formed as one piece. The connecting channel is formed by opening a through hole. Compared with the two separate structures of the liquid injection cover 10 and the scraping cover 20 connected by a conduit, the liquid injection cover 10 and the scraping cover 20 can share a side wall, which has a simpler structure and is more convenient for later cleaning and maintenance. There is less contact with the external environment, which reduces the risk of pollution. In addition, the setting of the through hole makes the scraper assembly scrape back to recover the excess microneedle forming liquid to the liquid injection chamber, and the reflux is smoother. Furthermore, it is preferred that the through hole is provided at the bottom of the side wall of the liquid injection cover 10, so that on the one hand, the liquid can flow easily into the scraping cavity 21, and on the other hand, after the scraping is completed, the excess liquid can be smoothly recovered into the liquid injection cavity 11 through the through hole by the scraper assembly 30. Of course, the communication channel 80 can also be a conduit, which is not limited to this.

[0044] In some preferred embodiments, the position of the liquid injection cover 10 is higher than the position of the scraping cover 20. This design allows the liquid in the liquid injection cover 10 to flow more smoothly into the scraping cover 20. Of course, the position of the liquid injection cover 10 can be flush with the position of the scraping cover 20, or the position of the liquid injection cover 10 can be slightly lower than the position of the scraping cover 20. Due to the vacuum environment that can be formed in the scraping cover 20, the liquid in the liquid injection cover 10 can also flow smoothly into the scraping cover 20 due to the pressure difference on both sides. Figure 1-Figure 4 、 Figure 6-Figure 7 As shown, and / or the bottom of the injection chamber 11 is an inclined surface inclined downwardly toward the scraping chamber 21, and / or the connecting channel 80 is an inclined channel inclined downwardly from the injection chamber 11 toward the scraping chamber 21; the inclined design setting can make the liquid in the injection chamber 10 flow more smoothly into the scraping cover 2, and the fluidity between the injection chamber 11 and the scraping chamber 21 is better.

[0045] In some preferred embodiments, the scraping device further includes an auxiliary pressurizing unit 70, such as Figure 2-Figure 7 As shown, the auxiliary pressurizing unit 70 is configured to apply pressure to the scraping cover 20 toward the microneedle forming mold 100. The auxiliary pressurizing unit 70 can be arranged above the scraping cover 20 to apply longitudinal pressure so that the scraping cover 20 and the microneedle forming mold 100 fit more closely, increase the sealing effect of the scraping cavity 21, and make the vacuum suction unit 50 have a faster suction rate and quickly reach the target vacuum degree.

[0046] In some preferred embodiments, the auxiliary pressurizing unit 70 is at least one of a hydraulic cylinder, a pneumatic press, a screw press, and a mechanical press. The output end of the above auxiliary pressurizing unit 70 can be connected to the upper surface of the scraping cover 20 to apply pressure in the longitudinal direction of the scraping cover 20, so that the scraping cover 20 fits more closely with the microneedle forming mold 100. A hydraulic cylinder is a common mechanical structure for applying longitudinal pressure. It pushes the piston up and down by the pressure of hydraulic oil, thereby generating longitudinal thrust. The hydraulic cylinder has the advantages of simple structure, large output force, and smooth movement. A pneumatic press uses a gas-liquid booster cylinder as a power source, and generates high-pressure output by combining pneumatic and hydraulic forces. This mechanical structure can generate huge pressure in a short period of time. A screw press is a forging machine that uses a screw and a nut as a transmission mechanism, and relies on a screw transmission to convert the forward and reverse rotational motion of the flywheel into the up and down reciprocating motion of the slider. This mechanical structure can change the output pressure and stroke by adjusting the relative position of the screw and the nut, and has high flexibility and adjustability. A mechanical press is a common cold stamping equipment. Its working principle is to use a motor to drive the flywheel to rotate, and then transmit the power of the flywheel to the crankshaft through mechanisms such as a clutch and a transmission gear. Finally, the connecting rod and the slider transmit the force to the scraping cover 20, thereby pressurizing the scraping cover 20. This mechanical structure has the advantages of simple structure, easy use, and high efficiency.

[0047] In some preferred embodiments, the liquid injection cover 10 is provided with a liquid injection port 12, which is connected to a liquid injection tube 41. The other end of the liquid injection tube 41 is connected to the liquid injection unit 40. The liquid injection unit 40 may include a liquid storage tank and an injection pump. The liquid storage tank stores microneedle forming liquid, and the injection pump pumps the liquid in the liquid storage tank into the liquid injection cavity 11 of the liquid injection cover 10 through the liquid injection tube 41.

[0048] In some preferred embodiments, the injection unit 40 includes a flow regulating valve, which is arranged between the injection unit 40 and the injection chamber 11; further, the flow regulating valve can be arranged on the injection pipe 41 of the injection unit, and by setting the flow regulating valve, the opening and closing of the injection pipe 41 can be controlled, and the flow of liquid injected into the injection chamber 11 can be controlled.

[0049] In some preferred embodiments, a vacuum suction port 22 is provided on the scraping cover 20 , a vacuum tube 51 is connected to the vacuum suction port 22 , and the other end of the vacuum tube 51 is connected to a vacuum suction unit 50 , which may be a vacuum pump.

[0050] In some preferred embodiments, Figure 3As shown, the thickness of the scraper assembly 30 is greater than or equal to the aperture of the vacuum suction port 22. During the movement of the scraper assembly 30, the front and rear spaces within the coating cover 20, which are dynamically divided by the scraper assembly 30, always remain relatively isolated. That is, even if the scraper assembly 30 passes through the vacuum suction port 22, due to the timely sealing of the scraper assembly 30, the two spaces will not be connected by gas due to the gap formed between the vacuum suction port 22 and the scraper assembly 30. This ensures that the space behind the scraper assembly 30 will not leak gas, avoiding the impact of insufficient air pressure on the filling effect.

[0051] In another preferred embodiment, the vacuum suction port 22 is provided on the top wall or side wall of the scraping cover 20 away from the liquid injection cover 10. During the movement of the scraper assembly 30, the interior of the scraping cover 20 is dynamically divided by the scraper assembly 30 into two relatively isolated spaces. That is, the space away from the connecting channel 80 is always isolated from the other side, preventing gas communication between this space and the connecting channel 80 or the liquid injection cover 10, which would cause the vacuum of the microneedle forming mold 100 to be prematurely broken before it comes into contact with the liquid, thereby ensuring the filling effect of the liquid and the vacuumized microneedle forming mold.

[0052] In a preferred embodiment, the vacuum suction unit 50 remains in a working state before the scraper assembly 30 scrapes back, and continues to vacuum the scraping cover 20 to ensure that the scraping chamber 21 is always in a target vacuum environment; when the scraper assembly 30 scrapes back, the vacuum suction unit 50 stops working and releases pressure through the vacuum suction port 22, so that the space on both sides of the scraper assembly 30 is in an atmospheric pressure state, making the scraping back smoother.

[0053] In some preferred embodiments, the vacuum suction unit 50 further includes a pressure regulating valve, which is disposed between the vacuum suction unit 50 and the coating chamber 21. Furthermore, the pressure regulating valve is disposed on the vacuum tube 51, and the opening and closing of the vacuum tube 51 and the gas flow in the vacuum tube 51 can be controlled by disposing the pressure regulating valve.

[0054] In some preferred embodiments, Figure 1As shown, the scraper assembly 30 includes a scraper 32 and a push-pull rod 34 connected to one side of the scraper 32, one end of the push-pull rod 34 passes through the side wall of the scraping cover 20 so that the push-pull rod 34 can drive the scraper 32 located in the scraping cavity 21 to move; the side wall of the scraper 32 is in close contact with the inner wall of the scraping cavity 21, and the bottom of the scraper 32 is in contact with the molding surface of the microneedle molding mold 100. The scraper 32 is configured to be movable relative to the microneedle molding mold 100 to block or open the connecting channel 80, and the scraper 32 pushes excess microneedle molding liquid back into the injection cavity 11 when scraping back. That is, when the push-pull rod 34 is driven to move in a direction away from the injection chamber 11 to move the scraper 32, the movement of the scraper 32 exposes the bottom of the microneedle forming mold 100, and the liquid flows and spreads on the microneedle forming mold 100 while filling the microneedle forming cavity 101; after all the microneedle forming cavities 101 of the microneedle forming mold 100 are initially filled, the push-pull rod 34 is driven to move to cause the scraper 32 to return and move in a direction closer to the injection chamber 11. The reverse movement of the scraper 32 further assists in the scraping and filling process, making the distribution more uniform and the filling effect better, thereby improving the uniformity of the quality of the microneedle finished product. In addition, the excess liquid is pushed back into the injection chamber 11 by the scraper 32, thereby recovering the excess liquid and avoiding liquid waste. In this embodiment, the scraper 32 can be a hard scraper, a flexible scraper with a certain structural strength, or a hybrid scraper with a hard middle part and a flexible outer edge, which is not limited here.

[0055] In a preferred embodiment, as 1, Figure 2 、 Figure 4 、 Figure 5 As shown, the outer edge of the scraper 32 and / or the fixed plate 31 of the scraper assembly 30 gradually shrinks along the extension direction of the push-pull rod, forming an inclined outer wall from the outer edge toward the central axis of the push-pull rod. This can reduce the contact area between the scraper 32 or the fixed plate 31 and the microneedle forming mold, reduce the risk of contamination, and make subsequent cleaning and maintenance more convenient.

[0056] Furthermore, the microneedle coating device preferably further includes a moving component 60 mounted outside the coating cover 20, such as Figure 4-Figure 7 As shown, the moving assembly 60 is connected to the push-pull rod 34 to push the push-pull rod 34 to move, so that the scraper can perform a scraping motion on the microneedle forming mold. Of course, the push-pull rod 34 can also be manually driven to move to push the scraper assembly 30 to perform a scraping motion.

[0057] Specifically, the moving component 60 includes a transmission member 61 and a moving driving member 62. The transmission member 61 is connected to the push-pull rod 34, and the moving driving member 62 is driven and connected to the transmission member 61 to drive the transmission member 61 to move. For example, the transmission member 61 can be a piston, a transmission shaft, a screw, a belt, a gear, a chain, etc., and the moving driving member 62 can be a cylinder, a motor, etc., and there is no specific limitation.

[0058] In some specific embodiments, such as Figure 6 As shown, the scraper 32 also includes a flexible scraping coating layer 35 extending from the outer edge of the scraper. The flexible scraping coating layer 35 is in close contact with the inner wall of the scraping cavity 21, and the bottom of the scraper 32 is in contact with the molding surface of the microneedle forming mold 100; the flexible scraping coating layer 35 has a certain structural strength. On the one hand, it can perform scraping work, and on the other hand, the design of the flexible scraping coating layer 35 can avoid damage to the scraping cover 20 and the microneedle forming mold 100.

[0059] In other specific embodiments, Figure 2-Figure 3 As shown, the scraper 32 is a flexible scraper, and the scraper assembly 30 also includes a fixed plate 31 that is attached to at least one side of the flexible scraper away from the liquid injection chamber 11. The other side of the fixed plate 31 is connected to the push-pull rod 34. Since the scraper 32 is made of a flexible material, the setting of the fixed plate 31 can provide support strength for the flexible scraper to prevent it from being deformed by external forces, thereby preventing it from affecting the scraping effect and incomplete liquid recovery. In this embodiment, the fixed plate 31 can be set separately on the back of the scraper 32, that is, between the scraper 32 and the push-pull rod 34. The fixed plate 31 can also be set on both sides of the scraper 32, and the two fixed plates 31 clamp the scraper 32.

[0060] In some preferred embodiments, the width of the scraper 32 is the same as the width of the inner wall of the scraping cavity 21, thereby ensuring that the excess liquid in the scraping cavity 21 is scraped back to the injection cavity 11 during backscraping, thereby preventing excess liquid from remaining on the surface of the microneedle forming mold 100. The scraper 32 can be a flexible scraper 32 or a hard scraper 32. Alternatively, the scraper 32 is a flexible scraper 32, and the width of the flexible scraper 32 is equal to or slightly wider than the width of the scraping cavity 21, which can ensure that the microneedle forming liquid is scraped back more completely, preventing excess liquid from remaining on the surface of the microneedle forming mold 100, and preventing the flexible scraper 32 from damaging the scraping mask 20 and the microneedle forming mold 100 during the scraping process. Alternatively, when a flexible scraping coating layer 35 is extended from the outer edge of the scraper 32, the sum of the widths of the scraper 32 and the flexible scraping coating layer 35 is equal to or slightly wider than the width of the scraping cavity, the microneedle forming liquid can be scraped back more completely, avoiding excess liquid from remaining on the surface of the microneedle forming mold 100, and at the same time avoiding the flexible scraper 32 from causing damage to the scraping cover 20 and the microneedle forming mold 100 during the scraping process.

[0061] In a specific embodiment, Figure 7 As shown, the bottom inner wall of the scraping cover 20 is provided with a positioning groove 23, which matches the microneedle forming mold 100. The outer edge of the microneedle forming mold 100 can be embedded in the open end of the scraping cover 20, and the positioning groove 23 limits the microneedle forming mold 100. The provision of the positioning groove 23 not only allows for rapid positioning of the scraping cover 20, but also prevents displacement of the microneedle forming mold 100 during the vacuum suction unit 50, thereby improving the sealing of the sealed scraping chamber 21. Furthermore, the positioning groove 23 preferably has an annular stepped structure for better positioning and limiting effects.

[0062] Furthermore, a sealing ring is preferably provided in the positioning groove 23, and the outer edge of the microneedle forming mold 100 abuts against the sealing ring; by providing the sealing ring, the sealing between the microneedle forming mold 100 and the scraping cover 20 can be improved, thereby ensuring the suction effect of the vacuum suction unit 50 on the scraping cavity 21.

[0063] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A microneedle coating device, characterized in that: The device comprises a liquid injection cover having a sealed liquid injection cavity, a scraping cover having a semi-enclosed scraping cavity, a scraper assembly, a liquid injection unit connected to the liquid injection cavity to inject microneedle forming liquid into the liquid injection cavity, and a vacuum suction unit connected to the scraping cavity to evacuate the scraping cavity; The open end of the scraping cover covers the forming surface of the microneedle forming mold, and the scraping cover and the microneedle forming mold define a closed scraping cavity; A connecting channel is provided between the injection chamber and the scraping chamber. The scraper assembly is provided in the scraping cover and abuts against the molding surface of the microneedle forming mold. The side wall of the scraper assembly is in contact with the inner side wall of the scraping chamber. The scraper assembly is configured to be movable relative to the microneedle forming mold to block or open the connecting channel, and the scraper assembly recovers excess microneedle forming liquid into the injection chamber when scraping back.

2. The microneedle coating device according to claim 1, characterized in that The liquid injection cover and the scraping cover are arranged side by side, a through hole is opened between the liquid injection cover and the scraping cover, the through hole forms the communicating channel, and the through hole is arranged at the bottom of the side wall of the liquid injection cover.

3. The microneedle coating device according to claim 2, characterized in that The position of the liquid injection cover is higher than that of the scraping cover; and / or the bottom of the liquid injection chamber is a slope inclined downward toward the scraping chamber; and / or the connecting channel is an inclined channel inclined downward from the liquid injection chamber toward the scraping chamber.

4. The microneedle coating device according to claim 1, characterized in that The scraping cover is provided with a vacuum suction port for connecting to a vacuum suction unit. The vacuum suction port is provided on the top wall or the side wall of the scraping cover away from the liquid injection cover.

5. The microneedle coating device according to claim 1, characterized in that The liquid injection unit includes a flow regulating valve, which is arranged between the liquid injection unit and the liquid injection chamber; the vacuum suction unit also includes an air pressure regulating valve, which is arranged between the vacuum suction unit and the coating chamber.

6. The microneedle coating device according to claim 1, characterized in that The scraper assembly includes a scraper and a push-pull rod connected to one side of the scraper, one end of the push-pull rod passes through the side wall of the scraping cover to drive the scraper located in the scraping cavity to move; the side wall of the scraper is in close contact with the inner wall of the scraping cavity, and the bottom of the scraper is in contact with the molding surface of the microneedle molding mold. The scraper is configured to be movable relative to the microneedle molding mold to block or open the connecting channel, and the scraper pushes excess microneedle molding liquid back into the injection cavity when scraping back.

7. The microneedle coating device according to claim 6, characterized in that The microneedle scraping device further includes a moving component located outside the scraping chamber, and the moving component is connected to the push-pull rod to drive the push-pull rod to move.

8. The microneedle coating device according to claim 6, characterized in that: The scraper is a flexible scraper, the width of which is equal to or slightly wider than the width of the scraping cavity; or, the scraper includes a flexible scraping coating layer extending from the outer edge, and the sum of the widths of the scraper and the flexible scraping coating layer is equal to or slightly wider than the width of the scraping cavity.

9. The microneedle coating device according to claim 1, characterized in that A positioning groove is provided on the inner wall of the bottom of the scraping cover, and the positioning groove matches the microneedle forming mold.

10. The microneedle coating device according to claim 9, characterized in that: A sealing ring is arranged in the positioning groove.

Images