A functional drug-loaded small molecule peptide that promotes ferroptosis in breast cancer cells
By designing a responsive small molecule peptide carrier, it can self-assemble and morphological transformation in the tumor microenvironment, solving the effectiveness and toxic side effects of existing anti-cancer drugs in the treatment of breast cancer, and achieving more efficient tumor suppression and induction of ferrodystrophy in cancer cells.
CN119019499BActive Publication Date: 2025-03-21WEIFANG MEDICAL UNIV
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Patent Information
- Application Number
- CN202411524955.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-30
- Publication Date
- 2025-03-21
- Estimated Expiration
- 2044-10-30
AI Technical Summary
Technical Problem
Existing anti-cancer drugs are difficult to effectively inhibit tumor growth and induce ferrous death in cancer cells when treating breast cancer, and have toxic side effects on normal cells.
Method used
A functional small molecule peptide is designed as a drug-loading carrier, which can respond to slightly acidic changes in the tumor microenvironment, self-assemble into spherical nanoparticles, and convert it into nanofibers in the acidic environment, prolong drug retention time and increase drug concentration.
Benefits of technology
This small molecule peptide carrier can significantly improve the cytotoxicity to breast cancer cells, reduce the toxic side effects on normal cells, and effectively inhibit tumor growth and induce iron death in cancer cells.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention discloses a functional drug-carrying small molecule peptide that promotes ferroptosis of breast cancer cells, and belongs to the technical field of the establishment and preparation of small molecule peptide nano drug carrier systems. The functional small molecule peptide responds to the slight acidity in the tumor microenvironment and can be used as a drug carrier, and the structural formula is shown in Figure 1. The functional drug-carrying small molecule peptide system PS / Pep1 of the present invention can target the coagulation plasma protein in tumor blood vessels, and can increase the cytotoxicity to tumor cells and reduce the toxic side effects to normal cells. PS / Pep1 undergoes a morphological change in the tumor microenvironment, and it co-loads PTX and SF, which increases the retention time of the combined drug in tumor cells. Compared with PS / Pep2, which cannot be morphologically transformed, PS / Pep1 more effectively inhibits tumor growth. More importantly, PS / Pep1 can effectively induce ferroptosis of breast cancer cells.
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