A skin barrier repair composition based on electrolyte response and its preparation method and application

Abstract

The present invention discloses a skin barrier repair composition based on electrolyte response and its preparation method and application, and relates to the field of cosmetic technology. The present invention provides a skin barrier repair composition based on electrolyte response, comprising the following components in parts by weight: 0.2-1.5 parts of acrylic acid (ester) copolymers containing carboxyl groups and / or acrylic acid (ester) copolymers containing sulfonic acid groups, 0.01-0.5 parts of glycerol glucoside, and 0.0005-0.01 parts of mevalonolactone; the mass percentage of the acrylic acid (ester) copolymers containing carboxyl groups and / or acrylic acid (ester) copolymers containing sulfonic acid groups in the skin barrier repair composition based on electrolyte response>50%. The present invention selects the above components for combined use, regulates the viscosity of the skin barrier repair composition within a suitable range, provides an excellent electrolyte response mechanism, better identifies the skin state, and thus correspondingly exerts the effect of reducing the skin transepidermal water loss value TWEL and repairing the skin barrier on the skin.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a skin barrier repairing composition based on electrolyte response, and a preparation method and application thereof. Background Art

[0002] At present, the repair cosmetic products on the market have the following shortcomings: (1) They are simply functional combinations that fail to take into account the effective absorption and utilization of active ingredients. For example, the active ingredients that are applied to cosmetics and then have an effect on the face are minimal. They are unable to accurately meet the repair needs of various skin types. (2) The impact on skin homeostasis, including whether the current state of the skin requires repair, cannot be identified, resulting in excessive skin supplementation or inappropriateness for the current skin state. Existing cosmetic products generally use active ingredients with a smaller molecular weight and utilize particle size to solve the penetration problem, or use a packaging process in the raw material production process to make the raw materials into inclusions and fit them to the skin components to solve the penetration problem. These methods cannot accurately meet the repair needs of various skin types and cannot repair the skin according to its current state.

[0003] Therefore, a skin barrier repair composition based on electrolyte response has broad application prospects. Summary of the invention

[0004] Based on this, the purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art and provide a skin barrier repair composition based on electrolyte response and its preparation method and application.

[0005] To achieve the above-mentioned object, in the first aspect of the present invention, the present invention provides a skin barrier repair composition based on electrolyte response, comprising the following components in parts by weight: 0.2-1.5 parts of acrylic acid (ester) copolymers containing carboxyl groups and / or acrylic acid (ester) copolymers containing sulfonic acid groups, 0.01-0.5 parts of glycerol glucoside, and 0.0005-0.01 parts of mevalonolactone; the mass percentage of the acrylic acid (ester) copolymers containing carboxyl groups and / or acrylic acid (ester) copolymers containing sulfonic acid groups in the skin barrier repair composition based on electrolyte response is greater than 50%; wherein the acrylic acid (ester) copolymers containing carboxyl groups and / or acrylic acid (ester) copolymers containing sulfonic acid groups are ... The carboxyl acrylic acid (ester) copolymer includes at least one of acrylic acid (ester) / vinyl isodecanoate cross-linked polymer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, acrylic acid (ester) / C10-30 alcohol acrylate cross-linked polymer sodium, and acrylic acid (ester) copolymer sodium; the acrylic acid (ester) copolymer containing sulfonic acid group includes at least one of acrylic acid / acrylamide methyl propane sulfonic acid copolymer, acrylamide / sodium acryloyldimethyl taurate copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and ammonium acryloyldimethyl taurate / VP copolymer.

[0006] The present invention selects a specific type of acrylic acid (ester) copolymer, and the molecular structure contains a large number of carboxyl and / or sulfonic acid groups with strong hydrophilicity and polarity. In water, these carboxyl and sulfonic acid groups will ionize to produce hydrogen ions (H + ), forming negatively charged carboxylate ions and sulfonate ions. The electrostatic repulsion between these negatively charged groups is the main reason why carboxyl-containing acrylic (ester) copolymers and / or sulfonic acid-containing acrylic (ester) copolymers form a stable structure and maintain high viscosity. When encountering electrolyte salts on the skin, positive and negative ions will form a solvation layer with the negative charges and water molecules on the molecules of these two substances respectively. This solvation will weaken the electrostatic repulsion between the molecular chains, which is called the "charge shielding effect". Hydrogen bonds can be formed between the carboxyl and / or sulfonic acid groups on the molecular chains of these two substances, which helps to maintain a stable structure. The addition of salt ions will compete with them to form hydrogen bonds, thereby destroying the original hydrogen bond network, causing the structure to collapse and the solution viscosity to decrease. After a large number of experiments, the inventors found that the amount of carboxyl-containing acrylic (ester) copolymers and / or sulfonic acid-containing acrylic (ester) copolymers will regulate the viscosity of the skin barrier repair composition within a suitable range, providing an excellent electrolyte response mechanism, so that it can provide different effects of water-soluble sensation according to the salt content on the skin surface. After a large number of experiments, the inventors found that the mass percentage of the carboxyl-containing acrylic (ester) copolymer and / or the sulfonic acid-containing acrylic (ester) copolymer in the electrolyte-responsive skin barrier repair composition is greater than 50% to provide an excellent electrolyte response mechanism.

[0007] After a large number of experiments, the inventor found that after mevalonate lactone and glycerol glucoside were compounded, the skin transepidermal water loss value TWEL would have a more obvious reduction, and the skin barrier repair effect would be better. This may be because glycerol glucoside can promote the expression of AQP water channel protein in the skin, so that the skin can better lock moisture. Mevalonate lactone can also promote the synthesis of intercellular lipids (cholesterol and fatty acids) in the stratum corneum. These lipids are the key components of the skin barrier. They form a tight lipid layer to prevent water loss and block the invasion of harmful substances from the outside. At the same time, glycerol glucoside will generate a moisturizing film for the skin surface, reduce water loss, and mevalonate lactone itself also has a strong moisturizing ability, can lock skin moisture, and prevent dry skin. Therefore, after mevalonate lactone and glycerol glucoside were compounded, the skin transepidermal water loss value TWEL would have a more obvious reduction, and the skin barrier repair effect would be better.

[0008] After a large number of experiments, the inventors found that when a specific weight portion of a carboxyl-containing acrylic acid (ester) copolymer and / or a sulfonic acid-containing acrylic acid (ester) copolymer is used in combination with a specific weight portion of mevalonate lactone and glycerol glucoside, on the one hand, the viscosity of the skin barrier repair composition is regulated within a suitable range, and an excellent electrolyte response mechanism is provided, so that it can provide different effects of water-removing sensation according to the salt content on the skin surface. On the other hand, based on the combination of an excellent electrolyte response mechanism, the skin state can be better identified, and mevalonate lactone and glycerol glucoside can correspondingly play the role of reducing the transepidermal water loss value TWEL and repairing the skin barrier on the skin.

[0009] Preferably, the electrolyte-responsive skin barrier repair composition comprises the following components in parts by weight: 0.5-1.2 parts of carboxyl-containing acrylic acid (ester) copolymers and / or sulfonic acid-containing acrylic acid (ester) copolymers, 0.3-0.4 parts of glycerol glucoside, and 0.004-0.008 parts of mevalonolactone.

[0010] Preferably, the mass percentage of the carboxyl-containing acrylic acid (ester) copolymer and / or the sulfonic acid-containing acrylic acid (ester) copolymer in the electrolyte-responsive skin barrier repairing composition is 68-78%.

[0011] After a large number of experiments, the inventors found that the mass percentage of the carboxyl-containing acrylic acid (ester) copolymer and / or the sulfonic acid-containing acrylic acid (ester) copolymer in the electrolyte response-based skin barrier repair composition has a great influence on the electrolyte response mechanism, further affecting the transepidermal water loss value of the skin and the effect of repairing the skin barrier.

[0012] Preferably, the electrolyte-responsive skin barrier repair composition comprises the following components in parts by weight: 0.1-0.6 parts of an acrylic acid (ester) copolymer containing a carboxyl group and 0.1-0.6 parts of an acrylic acid (ester) copolymer containing a sulfonic acid group.

[0013] More preferably, the weight ratio of the acrylic acid (ester) copolymer containing carboxyl groups to the acrylic acid (ester) copolymer containing sulfonic acid groups is 1:1.

[0014] After a large number of experiments, the inventors found that when the acrylic acid (ester) copolymer containing carboxyl groups and the acrylic acid (ester) copolymer containing sulfonic acid groups coexist, the electrolyte response mechanism is better, the transepidermal water loss value of the skin is lower, and the effect of repairing the skin barrier is better. And when the weight ratio of the acrylic acid (ester) copolymer containing carboxyl groups and the acrylic acid (ester) copolymer containing sulfonic acid groups is 1:1, the effects in all aspects are more excellent.

[0015] Preferably, the acrylic acid (ester) copolymer containing carboxyl groups is sodium acrylic acid (ester) copolymer, and / or the acrylic acid (ester) copolymer containing sulfonic acid groups is ammonium acryloyldimethyltaurate / VP copolymer.

[0016] After a large number of experiments, the inventors found that sodium acrylate copolymers have more significant advantages when used in skin barrier repair compositions based on electrolyte response: (1) Stronger thickening effect; carboxylates are easier to absorb water than carboxyl groups, so sodium acrylate copolymers can more effectively increase the viscosity of the solution. Therefore, when applied to cosmetics, it is directly reflected in the texture and feel of the product, such as thicker emulsions and easier to apply gels; (2) Better emulsification performance; carboxylates have stronger hydrophilicity while maintaining a certain lipophilicity, so they are more suitable as emulsifiers to help oily and aqueous components mix more evenly and form more stable emulsions. This means that the product is less likely to stratify and is more easily absorbed by the skin; (3) Better film-forming effect; carboxylates can form a more stable film, more effectively lock in moisture, and provide better protection to prevent external stimuli from damaging the skin. In cosmetics, this can be manifested as a more lasting moisturizing effect, a stronger protective function, and a more delicate skin feel. (4) Milder properties: Carboxylates are more stable than carboxyl groups and are less susceptible to oxidation or degradation. In cosmetics, this means lower irritation and better suitability for sensitive skin.

[0017] After a large number of experiments, the inventors found that ammonium acryloyldimethyltaurate / VP copolymer has more significant advantages when used in electrolyte-responsive skin barrier repair compositions: (1) Excellent thickening effect: The taurine group in ammonium acryloyldimethyltaurate / VP copolymer can form strong hydrogen bonds with water, making it have stronger thickening ability than general sulfonic acid groups. This thickening effect can make the product thicker and more textured, and improve its spreadability and ductility, thereby enhancing the feel of use. (2) Better biocompatibility: Taurine is a naturally occurring amino acid that plays an important physiological role in the human body. Therefore, ammonium acryloyldimethyltaurate / VP copolymer has higher biocompatibility than traditional sulfonic acid polymers, is milder, and is less likely to irritate the skin. (3) Stronger stability: The taurine group can effectively prevent the polymer from degrading, making it more stable during storage and less likely to change in performance. This is very important for cosmetics, as it can ensure that the product maintains its stability and efficacy during long-term use.

[0018] In the second aspect of the present invention, the present invention provides a method for preparing the electrolyte-responsive skin barrier repairing composition, comprising the following steps:

[0019] S1. Weigh each component according to weight;

[0020] S2. Mix the above components at 25-30° C. to obtain the electrolyte-responsive skin barrier repair composition.

[0021] In the third aspect of the present invention, the present invention provides the use of the electrolyte-responsive skin barrier repair composition in the preparation of cosmetics.

[0022] In a fourth aspect of the present invention, the present invention provides a cosmetic comprising the electrolyte-responsive skin barrier repairing composition.

[0023] The inventors discovered during actual experiments that the electrolyte response-based skin barrier repair composition provided by the present invention can be added into different cosmetics as an effective ingredient, thereby achieving the effect of dynamically monitoring the skin condition, providing an excellent electrolyte response mechanism, and correspondingly reducing the transepidermal water loss value TWEL and repairing the skin barrier on the skin.

[0024] Preferably, the cosmetic comprises the following components in percentage by mass: 0.5-8% of the electrolyte-responsive skin barrier repairing composition, 5-20% of the cosmetic base, and the balance of water.

[0025] Preferably, the cosmetic matrix includes at least one of an emulsifier, a thickener, an antioxidant, a chelating agent, a moisturizer, a preservative, and a fragrance.

[0026] Exemplarily, the emulsifier includes sodium stearoyl glutamate, cetearyl alcohol, C14-22 alcohol, steareth-21, polyglyceryl-10 laurate, potassium cetyl phosphate, PEG-100 stearate, polysorbate-60, PEG-150 distearate, PEG-30 soybean sterol, polyglyceryl-10 stearate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-5 trioleate, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PPG-13-decyltetradecyl alcohol polyether-24, nonylphenol polyether-12, stearyl alcohol polyether-2, stearyl alcohol polyether-21, at least one of hydrogenated lecithin; the thickener includes xanthan gum, carbomer, sclerotium gum, hydrolyzed sclerotium gum, carbomer, hydroxy At least one of ethyl cellulose, carrageenan, rose bean gum, guar gum, carboxymethyl cellulose, and sodium polyacrylate; the antioxidant includes at least one of ergothioneine, tocopherol (vitamin E), ascorbyl tetraisopalmitate, and pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate); the chelating agent includes at least one of disodium EDTA and tetrasodium glutamate diacetate; the moisturizing agent includes at least one of hexylene glycol, pentylene glycol, propylene glycol, glycerol, butylene glycol, dipropylene glycol, polyethylene glycol, diglycerol, maltose, ethylene glycol, erythritol, mannitol, xylitol, glucose, lactose, maltose, fructose, inositol, sorbitol, sorbitan, trehalose, and starch hydrolyzate; the preservative includes at least one of p-hydroxyacetophenone and butyl parahydroxybenzoate.

[0027] Preferably, the cosmetics include any one of lotion, emulsion, ointment, cream, mask, essence, and spray.

[0028] Illustratively, the present invention provides an emulsion comprising the following components in percentage by weight: 0.5-8% of an electrolyte-responsive skin barrier repair composition, 0.5-2% of PEG-100 stearate, 0.05-0.1% of xanthan gum, 0.001-0.1% of ergothioneine, 0.01-0.04% of disodium EDTA, 0.5%-3% of hexylene glycol, 1-3% of pentylene glycol, 2-5% of propylene glycol, and the remainder of water.

[0029] Compared with the prior art, the beneficial effects of the present invention are as follows: when the present invention selects a specific weight portion of a carboxyl-containing acrylic acid (ester) copolymer and / or a sulfonic acid-containing acrylic acid (ester) copolymer and a specific weight portion of a selected mevalonate lactone and glycerol glucoside for use in combination, on the one hand, the viscosity of the skin barrier repair composition is regulated within a suitable range, and an excellent electrolyte response mechanism is provided, so that it can provide different effects of watering according to the salt content on the skin surface. On the other hand, based on the combination of an excellent electrolyte response mechanism, the skin state is better identified, and mevalonate lactone and glycerol glucoside correspondingly play the role of reducing the transepidermal water loss value TWEL of the skin and repairing the skin barrier on the skin. DETAILED DESCRIPTION

[0030] In order to better illustrate the purpose, technical scheme and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. Its purpose is to understand the content of the present invention in detail, rather than to limit the present invention. All other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Unless otherwise specified, the experimental reagents and instruments designed for the implementation and comparative examples of the present invention are all commonly used ordinary reagents and instruments, which can be obtained from commercial channels. In the implementation and comparative examples, the experimental methods used are conventional methods unless otherwise specified; and unless otherwise specified, the raw materials used in parallel experiments are the same batch of raw materials.

[0031] Acrylic acid (ester) copolymer containing carboxyl group-1: sodium acrylic acid (ester) copolymer;

[0032] Carboxyl-containing acrylic acid (ester) copolymer-2: acrylic acid (ester) / vinyl isodecanoate crosspolymer;

[0033] Sulfonic acid group-containing acrylic acid (ester) copolymer-1: ammonium acryloyldimethyltaurate / VP copolymer;

[0034] Sulfonic acid group-containing acrylic acid (ester) copolymer-2: acrylamide / sodium acryloyl dimethyl taurate copolymer;

[0035] Examples 1-12 and Comparative Examples 1-8

[0036] The present invention provides a skin barrier repair composition based on electrolyte response, and the components and weight portions are selected as shown in Table 1-2 below. The preparation method of the skin barrier repair composition based on electrolyte response is: S1. Weigh each component according to the weight portions shown in Table 1-2; S2. Mix the above components at 30°C to obtain the skin barrier repair composition based on electrolyte response. When preparing the composition of the comparative example, if there is no relevant component, do not add it. If there are other components, add them together and mix them evenly.

[0037] Table 1

[0038]

[0039]

[0040] Table 2

[0041]

[0042]

[0043] Application Examples

[0044] Application Examples 1-13, Comparative Application Examples 1-8, and Blank Application Examples of the present invention provide an emulsion, the components (mass percentage) of the emulsion are shown in Table 3; wherein the electrolyte-responsive skin barrier repair compositions in Application Examples 1-12 are respectively the electrolyte-responsive skin barrier repair compositions prepared in Examples 1-12; the electrolyte-responsive skin barrier repair compositions in Comparative Application Examples 1-8 are respectively the electrolyte-responsive skin barrier repair compositions prepared in Comparative Examples 1-8; for example, the electrolyte-responsive skin barrier repair composition used in Application Example 5 is the electrolyte-responsive skin barrier repair composition prepared in Example 5, and the same applies to the others; the electrolyte-responsive skin barrier repair composition used in Application Example 13 is the electrolyte-responsive skin barrier repair composition prepared in Example 5.

[0045] Table 3

[0046]

[0047] The preparation method of the cosmetic emulsion comprises the following steps: adding a chelating agent, a thickener and a moisturizing agent into water and stirring evenly to obtain an aqueous phase; homogenizing the emulsifier and the aqueous phase at 75° C., cooling to 40° C., adding a skin barrier repairing composition and an antioxidant, stirring evenly to obtain the cosmetic emulsion.

[0048] Performance Test-1 Electrolyte Concentration Response Test.

[0049] In order to verify the response ability of the electrolyte-responsive skin barrier repair composition to changes in electrolyte concentration, an electrolyte concentration response test was performed.

[0050] Testing instruments: mixer IKA RW20, viscometer: IKA ROTAVISC ME-VI;

[0051] Test samples: electrolyte-responsive skin barrier repair compositions prepared in Examples 1-12 and Comparative Examples 1-8; commercially available analytically pure sodium chloride and analytically pure calcium chloride of any brand;

[0052] Test steps: 0.12 g of analytically pure sodium chloride and 0.06 g of analytically pure calcium chloride were added to the electrolyte-responsive skin barrier repair compositions prepared in Examples 1-12 and Comparative Examples 1-8, respectively, and the stirrer was turned on at a speed of 500 rpm. After stirring for 5 minutes, the stirrer was turned off to obtain a mixture. The initial viscosity of the electrolyte-responsive skin barrier repair compositions prepared in Examples 1-12 and Comparative Examples 1-8 was measured using a viscometer, SP-10, at 10 rpm, and the viscosity of the mixture after adding 0.12 g of analytically pure sodium chloride and 0.06 g of analytically pure calcium chloride was further measured.

[0053] Change rate = (initial viscosity - mixture viscosity) / initial viscosity.

[0054] The results are shown in Table 4.

[0055] Table 4

[0056]

[0057]

[0058] It can be seen from the above table that the electrolyte response-based skin barrier repair composition prepared in the embodiment of the present invention has a change rate of more than 70%, and has a good electrolyte response effect.

[0059] Performance Test-2: Penetration Performance Test.

[0060] In order to verify the effect of being more easily absorbed achieved by the electrolyte-responsive skin barrier repair composition of the present invention in response to electrolyte changes, the electrolyte-responsive skin barrier repair compositions prepared in Examples 1-12 and Comparative Examples 1-8 were subjected to an in vitro transdermal diffusion test using a fully automatic transdermal diffusion instrument.

[0061] Test instrument: fully automatic transdermal diffusion tester, Franz diffusion cell.

[0062] Test steps: (1) Fix the cut three-dimensional epidermis at the connection between the supply tank and the receiving tank, with the epidermis facing upward and the dermis connected to the receiving tank. Add ethanol solution (the volume fraction of ethanol in the ethanol solution is 30%)-physiological saline as the receiving solution to the receiving tank, remove all bubbles, label each test sample with fluorescein, take 5g of the test sample and evenly apply it on the gasket, remove the excess sample around the gasket, place it on the skin, and fix it with a knob; (2) The volume of the receiving tank is 12mL, and the temperature is 600r / min. -1Stir at a constant speed and temperature of 37°C, take a sample of 5 mL at 8 hours after the start of the test, add an equal volume of fresh receiving solution in time, filter, take the filtrate and observe it under a fluorescence microscope; the fluorescently labeled compound will emit a specific fluorescence signal and signal intensity when passing through the sample, which can be directly displayed under the microscope. The higher the fluorescence intensity, the greater the amount of penetration, and the better the permeability.

[0063] Test results: as shown in Table 5.

[0064] Table 5

[0065]

[0066]

[0067] It can be seen from the above table that the electrolyte-responsive skin barrier repair composition prepared in the embodiment of the present invention has a fluorescence intensity of more than 10 and good permeability.

[0068] Performance testing-3 security testing.

[0069] The effect examples of the present invention verify the safety of application examples 1-13, comparative application examples 1-8, and blank application examples on human skin. According to the human skin patch test "Cosmetic Safety Technical Specifications" (2015), 33 volunteers aged 18-60 were recruited for the test, and the test environment was temperature (21±1)℃ and humidity (50±10)%. The volunteers washed their forearms with clean water, and after 5-10 minutes, after the water in the forearms evaporated, the testers applied 0.020-0.025g of each group of samples to each small chamber of the patch tester, and selected the inner side of the two forearms of the volunteers, avoiding the skin of the front and back hand joints. Each arm was attached with a sampled patch tester, and corresponding marks were made. The patch time lasted for 24 hours, and the patch tester was removed and the residual sample was wiped. The skin reaction was observed for 0.5h, 24h, and 48h, and the results were recorded according to the skin reaction grading standard in the "Cosmetic Safety Technical Specifications" (2015). As shown in Table 6, skin reactions are divided into 4 scoring levels, and the higher the score, the higher the severity of the skin irritation reaction.

[0070] The test results are shown in Table 7. It can be seen from the test results that in the technical solution provided by the present invention, 0 cases of withdrawal and 0 cases of adverse reactions occurred.

[0071] Table 6

[0072]

[0073] Table 7

[0074]

[0075]

[0076]

[0077] It can be seen from the above table that the cosmetic emulsions provided by Application Examples 1-13 of the present invention, Comparative Application Examples 1-8, and Blank Application Examples are all non-irritating.

[0078] Performance Test-4: Skin Transepidermal Water Loss Test (TWEL) and Stratum Corneum Moisture Content Test.

[0079] Test population: healthy women or men aged 18-40, with no obvious skin lesions, scars, hair, etc. on their facial skin, who can cooperate with the test according to the requirements of the test plan and maintain a regular life during the entire test period. Number of subjects: 3 people / group, a total of 66 people.

[0080] Test samples: emulsions of Application Examples 1-13, Comparative Application Examples 1-8, and Blank Application Example.

[0081] Stratum corneum water content measurement: by skin capacitance meter (CorneometerCM 825), the instrument can measure the water content of the superficial layer of the epidermis about 0.1 mm deep, and express the measured value in arbitrary units, and the subsequent calculation uses the average of 3 measurements. TWEL measurement: measured by evaporation meter (Tewameter8TMXEX), the probe is balanced on the skin for 30 seconds, and then the TEWL value is recorded for two minutes.

[0082] Test steps:

[0083] The subject takes 0.5g of the test sample and applies it evenly to the entire face, massaging until it is completely absorbed; use the test sample twice a day, once in the morning and once in the evening; the subjects are prohibited from using any other skin care products during the test period; use the test sample for 15 consecutive days, and conduct visit tests on the 0th day, the 7th day and the 15th day respectively.

[0084] After the subject's visit, he / she should clean his / her face with a cleansing product and dry his / her skin with a dry tissue. Then he / she should sit quietly in a laboratory with a temperature of 21℃±1℃ and a humidity of 50%RH±10%RH for 30 minutes. The test instrument should be used to record the initial moisture content and transepidermal water loss value of the subject's skin. After the test, the sample should be distributed and the subject should leave the laboratory. The test should be used again that night.

[0085] On Day 0, i.e. the test day, after the subject's visit, he / she first cleansed his / her face with a facial cleanser and wiped the skin dry with a dry facial tissue. He / she sat quietly in a laboratory with a temperature of 21°C ± 1°C and a humidity of 50% RH ± 10% RH for 30 minutes. The moisture content of the stratum corneum on the subject's face and the transepidermal water loss value of the skin were tested before applying the application sample (i.e. 0h) and 0.5h after applying the test sample.

[0086] After the subjects' visit on the 7th and 15th days, they first cleaned their faces with a cleansing product and dried their skin with dry facial tissues, and sat in a laboratory with a temperature of 21℃±1℃ and a humidity of 50%RH±10%RH for 30 minutes for testing.

[0087] Change rate = (0.5h on day 0 - 0h on day 0) / 0h on day 0.

[0088] Change rate = (after use - 0h on day 0) / 0h on day 0.

[0089] Test results: as shown in Table 8.

[0090] Table 8

[0091]

[0092]

[0093]

[0094] It can be seen from the above table that the emulsions prepared in Application Examples 1-13 of the present invention have good skin barrier repair effects, and perform excellently in both immediate repair and long-term repair.

[0095] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A skin barrier repair composition based on electrolyte response, characterized in that: The composition comprises the following components in parts by weight: 0.2-1.5 parts of an acrylic acid (ester) copolymer containing a carboxyl group and / or an acrylic acid (ester) copolymer containing a sulfonic acid group, 0.01-0.5 parts of glycerol glucoside, and 0.0005-0.01 parts of mevalonolactone; the mass percentage of the acrylic acid (ester) copolymer containing a carboxyl group and / or the acrylic acid (ester) copolymer containing a sulfonic acid group in the skin barrier repair composition based on electrolyte response is greater than 50%; Wherein, the carboxyl-containing acrylic acid (ester) copolymer is at least one of acrylic acid (ester) / vinyl isodecanoate cross-linked polymer and acrylic acid (ester) copolymer sodium; The acrylic acid (ester) copolymer containing sulfonic acid group is at least one of acrylamide / sodium acryloyldimethyltaurate copolymer and ammonium acryloyldimethyltaurate / VP copolymer.

2. The skin barrier repair composition based on electrolyte response according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 0.5-1.2 parts of acrylic acid (ester) copolymer containing carboxyl group and / or acrylic acid (ester) copolymer containing sulfonic acid group, 0.3-0.4 parts of glycerol glucoside, and 0.004-0.008 parts of mevalonolactone.

3. The skin barrier repair composition based on electrolyte response according to claim 1, characterized in that: The mass percentage of the carboxyl-containing acrylic acid (ester) copolymer and / or the sulfonic acid-containing acrylic acid (ester) copolymer in the electrolyte-responsive skin barrier repairing composition is 68-78%.

4. The skin barrier repair composition based on electrolyte response according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 0.1-0.6 parts of an acrylic acid (ester) copolymer containing a carboxyl group and 0.1-0.6 parts of an acrylic acid (ester) copolymer containing a sulfonic acid group.

5. The electrolyte-responsive skin barrier repair composition according to claim 4, characterized in that: The weight ratio of the acrylic acid (ester) copolymer containing carboxyl groups to the acrylic acid (ester) copolymer containing sulfonic acid groups is 1:

1.

6. The electrolyte-responsive skin barrier repair composition according to claim 1, characterized in that: The acrylic acid (ester) copolymer containing carboxyl groups is a sodium acrylic acid (ester) copolymer, and / or the acrylic acid (ester) copolymer containing sulfonic acid groups is an ammonium acryloyldimethyltaurate / VP copolymer.

7. A method for preparing the electrolyte-responsive skin barrier repairing composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1. Weigh each component according to weight; S2. Mix the above components at 25-30° C. to obtain the electrolyte-responsive skin barrier repair composition.

8. Use of the electrolyte-responsive skin barrier repairing composition according to any one of claims 1 to 6 in the preparation of cosmetics.

9. A cosmetic, characterized in that: The cosmetic comprises the electrolyte-responsive skin barrier repair composition according to any one of claims 1 to 6.

10. The cosmetic according to claim 9, characterized in that The cosmetic comprises the following components in percentage by weight: 0.5-8% of a skin barrier repair composition based on electrolyte response, 5-20% of a cosmetic base, and the balance of water; the cosmetic base comprises at least one of an emulsifier, a thickener, an antioxidant, a chelating agent, a moisturizer, a preservative, and a fragrance.

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