Microreactor fully automatic feeding device

Abstract

The present invention discloses a fully automatic feeding device for a microreactor, which belongs to the technical field of laboratory microreactors, and specifically includes an automated liquid circuit connection unit, a real-time monitoring and positioning unit, an automatic bubble exhaust and power unit, and a manipulator pick-up and placement unit; the automated liquid circuit connection unit is connected to the automatic bubble exhaust and power unit through a pipeline; the automated liquid circuit connection unit, the real-time monitoring and positioning unit, the automatic bubble exhaust and power unit, and the manipulator pick-up and placement unit are coordinated and controlled by a control module and powered. This solution can realize the automation of the microreactor feeding system, has the functions of automatically connecting the liquid circuit, automatically removing the bubbles in the pipeline, automatically replacing the reaction liquid container, and real-time monitoring of the remaining amount of the reaction liquid, and can run continuously without manual intervention. It improves the continuity and reliability of the experiment, reduces the waste of reagents, and improves the overall safety.

Description

Technical Field

[0001] The invention relates to the technical field of laboratory microreactors, and in particular to a microreactor fully automatic feeding device. Background Art

[0002] Microreactor technology has become an indispensable tool at the laboratory level due to its fast and efficient characteristics. Microreactors can carry out chemical reactions under precise conditions, significantly improving the reaction speed and product quality. However, the current microreactor system feeding device mainly relies on manual operation to connect pipelines and replace reagent bottles, which is not only time-consuming and labor-intensive, but may also introduce operational errors, affecting the accuracy and repeatability of the reaction.

[0003] Some feeding devices use a cam horizontal flow pump with a very small flow rate. When switching materials to introduce bubbles, the bubbles need to be manually discharged, which reduces the degree of automation of the entire system. There are also shortcomings such as the inability to monitor the remaining amount of the reaction liquid in real time and the need for continuous manual inspection.

[0004] The above contents are only used to assist in understanding the technical solution of the present invention and do not constitute an admission that the above contents are prior art. Summary of the invention

[0005] The main purpose of the present invention is to provide a microreactor feeding system that can achieve fully automated operation. It has the functions of automatically connecting liquid circuits, automatically removing pipeline bubbles, seamlessly replacing reagent bottles, and real-time monitoring of the remaining amount of reaction liquid, so that it can continue to operate without human intervention. It improves the continuity and reliability of experiments, reduces reagent waste, and improves overall safety, especially when dealing with highly active or dangerous chemicals.

[0006] To achieve the above-mentioned object, the present invention provides a microreactor fully automatic feeding device, which comprises an automated liquid circuit connection unit, a real-time monitoring and positioning unit, an automatic bubble exhaust and power unit, and a manipulator pick-up and placement unit; the automated liquid circuit connection unit is connected to the automatic bubble exhaust and power unit through a pipeline; the automated liquid circuit connection unit, the real-time monitoring and positioning unit, the automatic bubble exhaust and power unit, and the manipulator pick-up and placement unit are coordinated and controlled by a control module and powered;

[0007] The automated liquid circuit connection unit comprises a lifting assembly, a Luer connector assembly and a reaction liquid container; the lifting assembly comprises a lifting plate sliding along a guide shaft; the Luer connector assembly comprises a male assembly and a female assembly that can be assembled and separated from the male assembly; the male assembly is fixedly arranged at one end of the lifting plate, and the female assembly is arranged on the reaction liquid container;

[0008] The real-time monitoring and positioning unit comprises a weighing scale and a positioning tray arranged on the weighing scale; the reaction liquid container is placed on the positioning tray;

[0009] The automatic bubble exhaust and power unit includes a three-way valve I, a horizontal flow pump, a three-way valve II and a peristaltic pump; the first port of the three-way valve I is connected to a reaction liquid container through a first pipeline, and the second port of the three-way valve I is connected to another reaction liquid container through a second pipeline; the third port of the three-way valve I is connected to the first port of the horizontal flow pump through a third pipeline, the second port of the horizontal flow pump is connected to the first port of the three-way valve II through a fourth pipeline, the second port of the three-way valve II is connected to the fifth pipeline as an outlet for the reaction liquid, the third port of the three-way valve II is connected to the first port of the peristaltic pump through a sixth pipeline, and the second port of the peristaltic pump is connected to a waste liquid container through a seventh pipeline;

[0010] The robot pick-and-place unit is used for picking up and placing the positioning tray.

[0011] Preferably, the lifting assembly includes a fixed plate I and a fixed plate II, and the fixed plate I and the fixed plate II are connected through the guide shaft; the lifting plate slides between the fixed plate I and the fixed plate II, and the lifting plate is connected to the output shaft of the driving motor, and the driving motor is fixed on one side of the fixed plate I; a sensor is provided on the fixed plate I or the fixed plate II, and the sensor is electrically connected to the control module.

[0012] Preferably, the male head assembly includes a Luer male head, a hollow transfer shaft, a compression spring and a locking nut. The compression spring is sleeved on the outer side of the hollow transfer shaft and abuts against one side of the lifting plate. The other side of the lifting plate is fixed with the hollow transfer shaft by the locking nut, and the lower end of the hollow transfer shaft is connected to the Luer male head.

[0013] Preferably, the female head assembly includes a Luer female head, a double-ended externally threaded straight-through, a through-plate joint, an inverted cone joint and a liquid collection tube; the through-plate joint is arranged on the cover of the reaction liquid container, the upper end of the through-plate joint is connected to the double-ended externally threaded straight-through, the upper end of the double-ended externally threaded straight-through is connected to the Luer female head, the lower end of the through-plate joint is connected to the liquid collection tube, the inverted cone joint is sleeved on the outside of the liquid collection tube, the inverted cone joint is connected to the through-plate joint, and the Luer male head matches the Luer female head.

[0014] Preferably, the reaction liquid container further comprises a container, and the covering member is fixed at the mouth end of the container.

[0015] Preferably, the weighing balance has a data port and transmits data to the control module in real time; a positioning pin is provided on the weighing balance's scale pan, a positioning pin hole is provided at the bottom of the positioning tray, and the positioning pin hole matches the positioning pin; a accommodating cavity is provided at the top of the positioning tray, and a pick-up and release hole is provided on the side of the positioning tray.

[0016] Preferably, the working modes of the automatic bubble exhaust and power unit include automatic bubble exhaust and reaction liquid delivery; the automatic bubble exhaust mode: controlling the first port of the three-way valve II to communicate with the third port of the three-way valve II, and starting the advection pump and the peristaltic pump;

[0017] The reaction liquid conveying mode: after completing the automatic bubble exhausting mode, the first port of the three-way valve II is controlled to be connected with the second port of the three-way valve II, and the peristaltic pump is closed.

[0018] Preferably, the robot pick-and-place unit includes a robot arm and a pick-and-place unit arranged at the end of the robot arm, and the pick-and-place unit includes an end flange and a pick-and-place pallet; the end flange and the pick-and-place pallet are hinged by equal-height step screws, and the pick-and-place pallet can rotate relative to the end flange with the equal-height step screws as the center of the circle; a step pin is arranged on the pick-and-place pallet, and the step pin matches the pick-and-place hole; an elastic part is arranged at the connection between the side of the pick-and-place pallet and the end flange.

[0019] The fully automatic feeding device for microreactor provided by the present invention has the following advantages:

[0020] 1. Improve operational efficiency and safety. The automated fluid connection unit of the present invention achieves fast and accurate connection and separation through Luer male and female connectors, greatly reducing the time and error rate of manual operation. It not only improves work efficiency, but also significantly improves the safety of experiments, especially when handling highly active or hazardous chemicals, avoiding direct contact.

[0021] 2. Ensure the accuracy and continuity of chemical reactions. The real-time monitoring and positioning unit ensures the continuity and stability of chemical reactions by continuously monitoring the amount of reaction liquid in the reagent bottle and automatically adjusting the feeding speed and time. This greatly improves the repeatability and reliability of the reaction, which is particularly critical for fine chemical processes such as drug synthesis.

[0022] 3. Automatic bubble exhaust improves system stability. The automatic bubble exhaust and power unit automatically exhaust bubbles introduced during material replacement or pipeline connection through special pump valve configuration and program. It reduces reaction instability and potential chemical accidents caused by bubbles and enhances the safety and controllability of the entire chemical process.

[0023] 4. The robot automatically replaces the reaction liquid container (reagent bottle) to improve the degree of automation. The robot pick-and-place unit ensures the rapid replacement and correct installation of the reaction liquid container through precise alignment and anti-misalignment functions. It not only improves the automation of the overall operation, but also ensures unattended operation of long-term experiments, reduces labor costs and improves the continuity of operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 Schematic diagram of an automated fluid connection unit according to an embodiment of the present invention.

[0025] Figure 2 It is a three-dimensional schematic diagram of a lifting assembly involved in an embodiment of the present invention.

[0026] Figure 3 It is a cross-sectional view of the male head assembly involved in the embodiment of the present invention.

[0027] Figure 4 It is a cross-sectional view of the female head assembly and the reaction liquid container involved in the embodiment of the present invention.

[0028] Figure 5 It is a schematic diagram of a real-time monitoring and positioning unit involved in an embodiment of the present invention.

[0029] Figure 6 It is a schematic diagram of the structure principle of the automatic bubble exhaust and power unit involved in the embodiment of the present invention.

[0030] Figure 7 Schematic diagram of a robot pick-and-place unit according to an embodiment of the present invention.

[0031] Figure 8 yes Figure 7 A is an enlarged view of the middle image.

[0032] Fig. 9 It is an overall three-dimensional schematic diagram of a fully automatic feeding device involved in an embodiment of the present invention.

[0033] Figure Number and Name:

[0034] 100. Fully automatic feeding device for microreactor;

[0035] 10. Automated fluid connection unit;

[0036] 101, lifting assembly; 1011, fixing plate I; 1012, fixing plate II; 1013, guide shaft; 1014, lifting plate; 1015, driving motor; 1016, sensor; 1017, flexible hose; 1018, first joint;

[0037] 102. Luer connector assembly;

[0038] 1021, male connector; 10211, Luer male connector; 10212, hollow adapter shaft; 10213, compression spring; 10214, locking nut;

[0039] 1022, female connector; 10221, Luer female connector; 10222, double-ended external threaded straight connector; 10223, through-plate connector; 10224, inverted cone connector; 10225, liquid extraction tube;

[0040] 103. reaction liquid container; 1031. cover; 1032. container;

[0041] 20. Real-time monitoring and positioning unit;

[0042] 201, weighing scale; 2011, positioning pin; 2012, data port;

[0043] 202, positioning tray; 2021, positioning pin hole; 2022, accommodating cavity; 2023, taking and placing hole;

[0044] 30. Automatic air bubble discharge and power unit;

[0045] 301, three-way valve I; 302, horizontal flow pump; 303, three-way valve II; 304, peristaltic pump;

[0046] 40. Robot pick-and-place unit;

[0047] 401, end flange; 402, pick-up and placement tray; 403, equal height step screws; 404, lubrication gasket; 405, elastic part; 406, step pin;

[0048] 50. Control module.

[0049] The realization of the purpose, functional features and advantages of the present invention will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0050] In order to make the purpose, technical solution and advantages of the embodiments of the present disclosure clearer, the technical solution of the embodiments of the present disclosure will be clearly and completely described below in conjunction with the drawings of the embodiments of the present disclosure. Obviously, the described embodiments are part of the embodiments of the present disclosure, rather than all of the embodiments. Based on the described embodiments of the present disclosure, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present disclosure.

[0051] See also Figure 1 , Figure 5 , Figure 6 , Figure 7 and Fig. 9The microreactor fully automatic feeding device 100 includes an automated liquid circuit connection unit 10, a real-time monitoring and positioning unit 20, an automatic bubble exhaust and power unit 30, and a manipulator pick-up and placement unit 40. The automated liquid circuit connection unit 10 is connected to the automatic bubble exhaust and power unit 30 through a pipeline; the automated liquid circuit connection unit 10, the real-time monitoring and positioning unit 20, the automatic bubble exhaust and power unit 30, and the manipulator pick-up and placement unit 40 are coordinated and controlled by a control module 50 and powered.

[0052] See also Figure 1 and Figure 2 The automated fluid connection unit 10 includes a lifting assembly 101, a Luer connector assembly 102 and a reaction liquid container 103.

[0053] The lifting assembly 101 is used to realize the assembly and separation of the Luer connector assembly 102. Figure 2 As shown, the lifting assembly 101 includes a fixing plate I 1011 and a fixing plate II 1012, wherein the fixing plate I 1011 and the fixing plate II 1012 are connected and fixed by a guide shaft 1013; a lifting plate 1014 is slidably arranged on the guide shaft 1013 between the fixing plate I 1011 and the fixing plate II 1012, and a male head assembly 1021 of the Luer connector assembly 102 is fixedly arranged at one end of the lifting plate 1014, and the other end of the lifting plate 1014 is connected to the output shaft (or ball screw) of the driving motor 1015, and the driving motor 1015 is fixed on one side of the fixing plate I 1011.

[0054] Driven by the driving motor 1015, the lifting plate 1014 is driven to slide along the guide shaft 1013 to realize the lifting function. It can be known that the driving motor 1015 that realizes the lifting function of the lifting plate 1014 can be a linear motor or a linear module, which is used to drive the lifting plate 1014 to slide up and down along the guide shaft 1013 to realize the lifting function.

[0055] Exemplarily, a sensor 1016, such as an optical coupling sensor, is disposed on the fixing plate I 1011 or the fixing plate II 1012. Figure 2 As shown, the sensor 1016 is disposed on the fixed plate II 1012 to detect the displacement and position of the lifting plate 1014. The sensor 1016 is electrically connected to the control module 50 and performs data communication, and can monitor the position information of the lifting plate 1014 in real time.

[0056] The male component 1021 fixed at one end of the lifting plate 1014 moves up and down with the lifting plate 1014, and one end of the male component 1021 faces the female component 1022 of the Luer connector assembly 102. The other end of the male component 1021 is connected to the first connector 1018 through the flexible hose 1017, and the other end of the first connector 1018 is connected to the automatic bubble exhaust and power unit 30 through a pipeline. The first connector 1018 is set on the fixed plate II 1012, and the flexible hose 1017 has a certain length and meets the maximum stroke of the male component 1021 when the lifting plate 1014 is raised and lowered.

[0057] The Luer connector assembly 102 includes a male assembly 1021 and a female assembly 1022, see Figure 3 The male head assembly 1021 includes a Luer male head 10211, a hollow transfer shaft 10212, a compression spring 10213 and a locking nut 10214. The outer side of the hollow transfer shaft 10212 is sleeved with the compression spring 10213 and abuts against the lifting plate 1014. The hollow transfer shaft 10212 is fixed on the other side of the lifting plate 1014 by the locking nut 10214. At the same time, the locking nut 10214 locks the flexible hose 1017 connected to the hollow transfer shaft 10212. The Luer male head 10211 is connected to the lower end of the hollow transfer shaft 10212, and the Luer male head 10211 matches the female head assembly 1022.

[0058] See also Figure 4 The female head assembly 1022 includes a Luer female head 10221, a double-ended external threaded straight-through connector 10222, a through-plate connector 10223, an inverted cone connector 10224 and a liquid extraction tube 10225. Among them, the through-plate joint 10223 is arranged on the covering piece 1031 of the reaction liquid container 103, the upper end of the through-plate joint 10223 is connected to the double-headed external threaded straight-through 10222, and the upper end of the double-headed external threaded straight-through 10222 is connected to the Luer female head 10221, and the Luer female head 10221 matches the Luer male head 10211, and can be assembled and separated; the lower end of the through-plate joint 10223 is connected to the liquid collection tube 10225, and an inverted cone joint 10224 is sleeved on the outside of the liquid collection tube 10225, and the inverted cone joint 10224 is connected to the lower end of the through-plate joint 10223 to realize the tightening of the liquid collection tube 10225, and the liquid collection tube 10225 penetrates into the bottom of the reaction liquid container 103.

[0059] The reaction liquid container 103 includes a cover 1031 and a container 1032. The cover 1031 is fixed to the mouth of the container 1032. It is known that the through-plate connector 10223 can be set at any position on the cover 1031, preferably at the center or edge position, for easy positioning and calibration.

[0060] When implementing the above embodiment, the reaction liquid is transferred to the container 1032 of the reaction liquid container 103. There is no limit on the capacity of the container, 50mL to 10L, or containers of other capacities are all acceptable. The cover 1031 and the container 1032 are made of different materials according to the properties of the reaction liquid to avoid reaction. For example, if the reaction liquid is a sodium hydroxide solution and the container is made of silicate glass, the cover 1031 should be made of rubber or metal. The cover 1031 and the container 1032 can be made of plastic, glass or metal. The female head component 1022 is installed on the covering member 1031, and the covering member 1031 and the container 1032 can be sealed and connected. The reaction liquid container 103 filled with the reaction liquid is placed in a set position. At this time, the female head component 1022 on the covering member 1031 corresponds to the male head component 1021 fixed on the lifting component 101, and the control module 50 controls the lifting component 101 to work, that is, the driving motor 1015 drives the lifting plate 1014 to rise and fall and slide along the guide shaft 1013, and the male head component 1021 fixed on the lifting plate 1014 moves up and down. Among them, the Luer male head 10211 is matched with the Luer female head 10221; during the descending process, the Luer male head 10211 and the Luer female head 10221 are first in contact, and the Luer male head 10211 can be just inserted into the Luer female head 10221, and continues to descend, the Luer male head 10211 begins to squeeze the Luer female head 10221, and the compression spring 10213 continuously accumulates force. As the lifting plate 1014 continues to descend, the elastic pressure of the Luer male head 10211 on the Luer female head 10221 increases. When a certain pressure value is reached, the Luer male head 10211 and the Luer female head 10221 are assembled together and remain stable under the elastic pressure, thereby ensuring the sealing effect of the Luer connector assembly 102; during the ascending process, that is, the reverse process of the above-mentioned assembly process, the elastic pressure decreases, and finally the Luer male head 10211 and the Luer female head 10221 are separated.

[0061] In order to smoothly separate the Luer male connector 10211 and the Luer female connector 10221 , when the reaction liquid container 103 is placed at a set position, the real-time monitoring and positioning unit 20 fixes the container 1032 .

[0062] The real-time monitoring and positioning unit 20 includes a weighing scale 201 and a positioning tray 202. Figure 5As shown, the weighing scale 201 is an electronic scale, which can transmit the weight change to the control module 50 in real time through the data port 2012; the weighing scale 201 is provided with a positioning pin 2011 on the scale plate. The bottom of the positioning tray 202 is provided with a positioning pin hole 2021, and the positioning pin hole 2021 matches the positioning pin 2011; the top of the positioning tray 202 is provided with a receiving cavity 2022, which is used to accommodate the container 1032 of the reaction liquid container 103 and fix it in the positioning tray 202; one side of the positioning tray 202 is provided with a pick-up and placement hole 2023 for the robot pick-up and placement unit 40 to pick up and place the positioning tray 202.

[0063] It should be noted that the container 1032 of the reaction liquid container 103 and the positioning tray 202 can be quickly fixed, and the fixing methods include snapping, locking, negative pressure adsorption, magnetic attraction or other methods that can achieve fixing.

[0064] See also Figure 6 The automatic bubble exhaust and power unit 30 includes a three-way valve I 301, a horizontal flow pump 302, a three-way valve II 303 and a peristaltic pump 304.

[0065] The first port 1a of the three-way valve I 301, the second port 1b of the three-way valve I 301, and the third port 1c of the three-way valve I 301 are respectively the first port, the first port, and the third port of the three-way valve I 301; the first port 2a of the horizontal flow pump 302 and the second port 2b of the horizontal flow pump 302 are respectively the first port and the second port of the horizontal flow pump 302; the first port 3a of the three-way valve II 303, the second port 3b of the three-way valve II 303, and the third port 3c of the three-way valve II 303 are respectively the first port, the second port, and the third port of the three-way valve II 303; the first port 4a of the peristaltic pump 304 and the second port 4b of the peristaltic pump 304 are respectively the first port and the second port of the peristaltic pump 304.

[0066] Please see again Figure 6 The first port 1a of the three-way valve I 301 is connected to the reaction liquid container 1 through the first pipeline P1, the second port 1b of the three-way valve I 301 is connected to the reaction liquid container 2 through the second pipeline P2, the third port 1c of the three-way valve I 301 is connected to the first port 2a of the horizontal flow pump 302 through the third pipeline P3, the second port 2b of the horizontal flow pump 302 is connected to the first port 3a of the three-way valve II 303 through the fourth pipeline P4, the second port 3b of the three-way valve II 303 is connected to the fifth pipeline P5 as the outlet of the reaction liquid, the third port 3c of the three-way valve II 303 is connected to the first port 4a of the peristaltic pump 304 through the sixth pipeline P6, and the second port 4b of the peristaltic pump 304 is connected to the waste liquid container through the seventh pipeline P7.

[0067] The horizontal flow pump includes a stepper motor, a control system (such as a single chip microcomputer), a one-way valve and other components. The flow rate is controlled by changing the stroke of the plunger or the reciprocating speed of the plunger. The reaction liquid is sucked into the pump body by the one-way valve or the reaction liquid is pressed out of the pump body. The flow rate range is 2μL~100uL.

[0068] The peristaltic pump is a high-precision peristaltic pump, and the sampling volume is also micro-upgraded. In addition, the three-way valve I 301, the horizontal flow pump 302, the three-way valve II 303 and the peristaltic pump 304 are all electrically connected to the control module 50.

[0069] The working mode of the automatic bubble exhaust and power unit 30 includes the automatic bubble exhaust function and the function of stably delivering the reaction liquid. The working mode is now described.

[0070] 1. Automatic bubble discharge function

[0071] The solution in the reaction liquid container 1 and the solution in the reaction liquid container 2 can be the same, both are reaction liquids; or they can be different, such as the solution in the reaction liquid container 1 is a cleaning liquid, and the solution in the reaction liquid container 2 is a reaction liquid. This application takes the example that the solution in the reaction liquid container 1 (103) and the solution in the reaction liquid container 2 (103) are the same and both are reaction liquids.

[0072] The reaction liquid container 1 (103) and the reaction liquid container 2 (103) are moved to the set position according to the description in the above-mentioned automated fluid path connection unit 10, and the assembly of the Luer connector assembly is completed.

[0073] It should be noted that the automated liquid circuit connection unit 10 and the real-time monitoring and positioning unit 20 can be set in multiple groups and matched; at the same time, multiple groups of automatic bubble exhaust and power units 30 can operate independently and in parallel. After the automated liquid circuit connection unit 10 completes the liquid circuit connection, the male head component 1021 and the female head component 1022 are assembled together to form a sealed connection. The reaction liquid container 1 (103) and the reaction liquid container 2 (103) are respectively connected to the three-way valve I 301 through the Luer connector assembly 102, the flexible hose 1017 and the first connector 1018, and the first connector 1018 is respectively connected to the first pipeline P1 and the second pipeline P2.

[0074] The three-way valve I 301 is controlled to switch to connect the first port 1a of the three-way valve I 301 with the third port 1c of the three-way valve I 301; the three-way valve II 303 is controlled to switch to connect the first port 3a of the three-way valve II 303 with the third port 3c of the three-way valve II 303; the horizontal flow pump 302 and the peristaltic pump 304 are started.

[0075] Under the action of the peristaltic pump 304, the reaction liquid in the reaction liquid container 1 enters the advection pump 302 through the first pipeline P1 and the third pipeline P3, then enters the peristaltic pump 304 through the first port 4a of the peristaltic pump 304 through the fourth pipeline P4 and the sixth pipeline P6, and finally flows into the waste liquid container through the second port 4b of the peristaltic pump 304 and the seventh pipeline P7. This process can completely remove the bubbles in the pipeline system, the valve part and the advection pump, and rinse and clean them. The bubble removal function is completed for the reaction solution container 1.

[0076] Continue to switch the second port 1b of the three-way valve I 301 to communicate with the third port 1c of the three-way valve I 301, and follow the above operation to complete the bubble exhaust function of the reaction liquid container 2.

[0077] 2. Function of conveying reaction liquid

[0078] After completing the bubble exhaust function for the reaction liquid container 1 and the reaction liquid container 2, the peristaltic pump 304 is turned off, and the three-way valve I 301 is controlled to switch to a certain state, such as the first port 1a of the three-way valve I 301 is connected to the third port 1c of the three-way valve I 301 or the second port 1b of the three-way valve I 301 is connected to the third port 1c of the three-way valve I 301. The three-way valve II 303 is controlled to switch to the first port 3a of the three-way valve II 303 and the second port 3b of the three-way valve II 303. Taking the reaction liquid container 1 as an example, under the action of the horizontal flow pump 302, the reaction liquid in the reaction liquid container 1 enters the horizontal flow pump 302 through the first pipeline P1 and the third pipeline P3, and flows out from the fourth pipeline P4 and the fifth pipeline P5 and enters the microreactor to participate in the microreaction. Under the control of the control module 50, the horizontal flow pump 302 can realize accurate control of the amount of the reaction liquid participating in the microreaction.

[0079] The weighing balance 201 of the real-time monitoring and positioning unit 20 monitors the weight of the reaction liquid container 1 in real time. When it is detected that the reaction liquid in the reaction liquid container 1 is about to be consumed, the three-way valve 1301 is controlled to switch to the reaction liquid container 2, that is, the second port 1b of the three-way valve 1301 is connected to the third port 1c of the three-way valve 1301. Since the bubbles have been removed in the automatic bubble removal mode, the three-way valve 1301 can be directly switched to select the reaction liquid container 2, and the reaction liquid is continuously provided to ensure that the reaction process of the micro-reaction continues.

[0080] Illustratively, in the above embodiment, when there is only one reaction liquid container 1 (103), the three-way valve I 301 can be omitted, that is, the reaction liquid container 1 (103) is connected to the first port 2a of the horizontal flow pump 302 through the third pipeline P3.

[0081] It should be noted that the peristaltic pump is used in conjunction with the advection pump, and the flow rate of the advection pump is easier to control than the flow rate of the peristaltic pump, and the flow rate is more accurate. On the other hand, the working principle of the advection pump is based on the action of centrifugal force. Obviously, in an air environment, the reaction liquid in the reaction liquid container 103 cannot be sucked in, and the peristaltic pump is required to cooperate to suck the reaction liquid and fully enter the pipeline, and discharge the bubbles inside the pipeline and the advection pump. It is known that the peristaltic pump can also be replaced by a plunger pump.

[0082] See also Figure 7 and Figure 8 The manipulator pick-and-place unit 40 includes a manipulator arm and a pick-and-place unit arranged at the end of the manipulator arm, specifically including an end flange 401 and a pick-and-place pallet 402. The end flange 401 and the pick-and-place pallet 402 are mechanically connected (hinged) by equal-height step screws 403, and a lubricating gasket 404 is provided at the connection between the pick-and-place pallet 402 and the equal-height step screws 403, preferably a copper gasket. A step pin 406 is provided on the pick-and-place pallet 402, and the step pin 406 matches the pick-and-place hole 2023 of the positioning tray 202. An elastic member 405 is provided at the connection between the side of the pick-and-place pallet 402 and the end flange 401, which is used to generate damping. It is known that the pick-and-place pallet 402 can rotate relative to the end flange 401 with the equal-height step screws 403 as the center of the circle. This structure can achieve the alignment of the step pin 406 with the pick-and-place hole 2023 of the positioning tray 202 by adjusting the rotation angle, which is convenient for picking and placing.

[0083] In the above embodiment, the control module 50 is electrically connected to the robot pick-and-place unit 40 .

[0084] In order to realize the intelligence of the microreactor fully automatic feeding device 100, the control module 50 also includes a microprocessor control unit and a drive unit. The microprocessor control unit starts the motor (including the drive motor, three-way valve I, the horizontal flow pump, the three-way valve II, the peristaltic pump, and the robotic arm) through the drive unit, and sends a control signal to the drive unit according to the output signal from the sensor or the set parameters to start and stop, switch the state, etc.

Claims

1. A fully automatic feeding device for a microreactor, characterized in that: The microreactor fully automatic feeding device (100) comprises an automated liquid circuit connection unit (10), a real-time monitoring and positioning unit (20), an automatic bubble exhaust and power unit (30), and a manipulator pick-up and placement unit (40); the automated liquid circuit connection unit (10) is connected to the automatic bubble exhaust and power unit (30) via a pipeline; the automated liquid circuit connection unit (10), the real-time monitoring and positioning unit (20), the automatic bubble exhaust and power unit (30), and the manipulator pick-up and placement unit (40) are coordinated and controlled by a control module (50) and powered; The automated liquid circuit connection unit (10) comprises a lifting assembly (101), a Luer connector assembly (102) and a reaction liquid container; the lifting assembly (101) comprises a lifting plate (1014) that slides along a guide shaft (1013); the Luer connector assembly (102) comprises a male assembly (1021) and a female assembly (1022) that can be assembled with and separated from the male assembly (1021); the male assembly (1021) is fixedly arranged at one end of the lifting plate (1014), and the female assembly (1022) is arranged on the reaction liquid container; The real-time monitoring and positioning unit (20) comprises a weighing scale (201) and a positioning tray (202) arranged on the weighing scale (201); the reaction liquid container is placed on the positioning tray (202); The automatic bubble exhaust and power unit (30) comprises a three-way valve I (301), a horizontal flow pump (302), a three-way valve II (303) and a peristaltic pump (304); the first port (1a) of the three-way valve I (301) is connected to a reaction liquid container via a first pipeline (P1), and the second port (1b) of the three-way valve I (301) is connected to another reaction liquid container via a second pipeline (P2); the third port (1c) of the three-way valve I (301) is connected to the first port (2a) of the horizontal flow pump (302) via a third pipeline (P3). ), the second port (2b) of the horizontal flow pump (302) is connected to the first port (3a) of the three-way valve II (303) through a fourth pipeline (P4), the second port (3b) of the three-way valve II (303) is connected to the fifth pipeline (P5) as an outlet of the reaction liquid, the third port (3c) of the three-way valve II (303) is connected to the first port (4a) of the peristaltic pump (304) through a sixth pipeline (P6), and the second port (4b) of the peristaltic pump (304) is connected to a waste liquid container through a seventh pipeline (P7); The robot pick-and-place unit (40) is used to pick up and place the positioning tray (202).

2. The microreactor fully automatic feeding device according to claim 1, characterized in that: The lifting assembly (101) comprises a fixed plate I (1011) and a fixed plate II (1012), wherein the fixed plate I (1011) and the fixed plate II (1012) are connected via the guide shaft (1013); the lifting plate (1014) slides between the fixed plate I (1011) and the fixed plate II (1012), and the lifting plate (1014) is connected to the output shaft of a drive motor (1015), wherein the drive motor (1015) is fixed to one side of the fixed plate I (1011); a sensor (1016) is provided on the fixed plate I (1011) or the fixed plate II (1012), and the sensor (1016) is electrically connected to the control module (50).

3. The fully automatic feeding device of the microreactor according to claim 2, characterized in that: The male head component (1021) comprises a Luer male head (10211), a hollow transfer shaft (10212), a compression spring (10213) and a locking nut (10214); the outer side of the hollow transfer shaft (10212) is sleeved with the compression spring (10213) and abuts against one side of the lifting plate (1014); the other side of the lifting plate (1014) fixes the hollow transfer shaft (10212) via the locking nut (10214); and the lower end of the hollow transfer shaft (10212) is connected to the Luer male head (10211).

4. The fully automatic feeding device for a microreactor according to claim 3, characterized in that: The female head assembly (1022) comprises a Luer female head (10221), a double-ended externally threaded straight-through (10222), a through-plate joint (10223), an inverted cone joint (10224) and a liquid extraction tube (10225); the through-plate joint (10223) is arranged on the cover (1031) of the reaction liquid container, the upper end of the through-plate joint (10223) is connected to the double-ended externally threaded straight-through (10222), and the double-ended The upper end of the external threaded straight-through (10222) is connected to the Luer female head (10221), the lower end of the through-plate joint (10223) is connected to the liquid collection tube (10225), the inverted cone joint (10224) is sleeved on the outside of the liquid collection tube (10225), the inverted cone joint (10224) is connected to the through-plate joint (10223), and the Luer male head (10211) matches the Luer female head (10221).

5. The fully automatic feeding device for microreactor according to claim 4, characterized in that: The reaction liquid container further comprises a container (1032), and the cover (1031) is fixed at the mouth end of the container (1032).

6. The fully automatic feeding device for a microreactor according to claim 2, characterized in that: The weighing scale (201) has a data port (2012) and transmits data to the control module (50) in real time; a positioning pin (2011) is provided on the weighing scale (201) scale pan, a positioning pin hole (2021) is provided at the bottom of the positioning tray (202), and the positioning pin hole (2021) matches the positioning pin (2011); a receiving cavity (2022) is provided at the top of the positioning tray (202), and a taking-in and putting hole (2023) is provided on the side of the positioning tray (202).

7. The fully automatic feeding device for a microreactor according to claim 2, characterized in that: The working modes of the automatic bubble exhaust and power unit (30) include an automatic bubble exhaust working mode and a reaction liquid delivery working mode; the automatic bubble exhaust working mode: controlling the first port (3a) of the three-way valve II (303) to communicate with the third port (3c) of the three-way valve II (303), and starting the advection pump (302) and the peristaltic pump (304); The reaction liquid conveying working mode: after completing the automatic bubble exhausting working mode, the first port (3a) of the three-way valve II (303) is controlled to be connected with the second port (3b) of the three-way valve II (303), and the peristaltic pump (304) is closed.

8. The fully automatic feeding device for a microreactor according to claim 6, characterized in that: The robot pick-and-place unit (40) comprises a robot arm and a pick-and-place unit arranged at the end of the robot arm, and the pick-and-place unit comprises an end flange (401) and a pick-and-place pallet (402); the end flange (401) and the pick-and-place pallet (402) are hinged by equal-height step screws (403), and the pick-and-place pallet (402) can rotate relative to the end flange (401) with the equal-height step screws (403) as the center of the circle; a step pin (406) is arranged on the pick-and-place pallet (402), and the step pin (406) matches the pick-and-place hole (2023); an elastic member (405) is arranged at the connection between the side of the pick-and-place pallet (402) and the end flange (401).

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