A blood purification adsorbent pre-filling mixing device

Abstract

The present invention relates to the technical field of mixing of blood purification adsorbents, and in particular to a mixing device before filling of blood purification adsorbents, which comprises a mixing tube 1; a mixing tube 2 is provided with a through hole 1 and a through hole 2 arranged between a particle feeding tube and a mixture discharging tube, the mixing tube 2 rotates around its own axis, the solution at the bottom of the mixing tube 2 flows from bottom to top, and an opening is provided at the top of the mixing tube 2; a floating rod is vertically slidably arranged inside the mixing tube 2, a sealing block is connected to the bottom end of the floating rod, a sealing ring is connected to the circumferential side wall of the floating rod, an air release cavity is provided inside the floating rod, the air inside the mixing tube 2 flows unidirectionally to the inside of the air release cavity, and a sealing member capable of closing or opening the top of the air release cavity is provided on the floating rod; and a negative pressure exhaust pipe is connected to the top of the mixing tube 1. The present invention can remove bubbles in the mixture of particles and solutions as much as possible, reduce the risk of bubbles in the particles, shorten the processing time, and is conducive to the uniform distribution of particles in the solution.

Description

Technical Field

[0001] The invention relates to the technical field of mixing blood purification adsorbents, and in particular to a mixing device for blood purification adsorbents before filling. Background Art

[0002] Blood purification adsorbents can effectively remove toxins, metabolic waste and pathogenic substances from the blood, and are of great significance for the treatment of diseases such as acute poisoning, uremia, and liver failure.

[0003] Typically, the preparation process of blood purification adsorbents involves the following steps: preparing porous particles, which can be various materials such as activated carbon, polymers, glass or metal oxides, and the porous structure can effectively adsorb toxins and waste in the blood; mixing the porous particles with a solution containing other additives such as cross-linkers and initiators to ensure that the particles are evenly dispersed; filling the mixed adsorbent into the perfusion column, and then solidifying the adsorbent to stabilize its structure and ensure that the adsorbent maintains its shape and function during the subsequent blood purification process; further washing, drying and screening the solidified adsorbent. Finally, the solidified porous particles are loaded into the blood purification device.

[0004] When porous particles are mixed with solutions, the solutions may not be able to completely fill all the pores, especially when the pores are small or the liquid viscosity is high. Air may be trapped in the pores, resulting in bubbles inside the particles, which will directly affect the effectiveness and safety of the blood purification adsorbent.

[0005] Referring to the Chinese patent document with the authorization announcement number CN219518514U, a hollow capsule sol device for removing bubbles is disclosed, which can puncture and remove bubbles in the colloid solution, but the device is only applicable to bubbles suspended in the liquid, and it is difficult to remove bubbles left in the pores. The traditional method currently used is to stir and mix the solution and particles in a container, and then discharge the bubbles by natural sedimentation or manual stirring. However, this method has shortcomings, such as a long time required and incomplete bubble discharge, so that in actual use, before blood perfusion, it is necessary to knock the purifier to release the bubbles in the adsorbent to ensure that there is no air in the adsorbent layer. In addition, during the static bubble removal process, the particles in the mixture may settle, resulting in uneven distribution of particles in the solution. Summary of the invention

[0006] In view of this, the present invention provides a blood purification adsorbent pre-filling mixing device, aiming to solve the technical problem that bubbles may exist inside the porous particles in the adsorbent in the prior art.

[0007] In order to solve the above technical problems, the present invention provides a blood purification adsorbent pre-filling mixing device, which adopts the following technical solutions: a blood purification adsorbent pre-filling mixing device, comprising a mixing tube 1 whose circumferential side wall is connected with a particle feed pipe and a mixture discharge pipe in sequence from top to bottom and a mixing tube 1 whose bottom is connected with a solution feed pipe;

[0008] A mixing tube 2 is vertically slidably inserted into the inner wall of the mixing tube 1 and a driving member for driving the mixing tube 2 to reciprocate vertically. The circumferential side wall of the mixing tube 2 is provided with a through hole 1 and a through hole 2 which are arranged in sequence in the vertical direction and are arranged between the particle feeding pipe and the mixture discharging pipe. A control member for controlling the mixing tube 2 to rotate around its own axis is provided between the mixing tube 1 and the mixing tube 2. A one-way valve that allows the solution to pass from bottom to top is provided at the bottom of the mixing tube 2. An opening coaxially arranged therewith is provided at the top of the mixing tube 2.

[0009] A floating rod is vertically slidably arranged inside the second mixing tube, the bottom end of the floating rod passes through the bottom of the second mixing tube and is connected to a sealing block capable of closing the bottom surface of the one-way valve, the circumferential side wall of the floating rod is connected to a sealing ring capable of closing the open bottom, a vertically extending air leakage cavity is opened inside the floating rod, an exhaust valve capable of allowing the air inside the second mixing tube to flow unidirectionally into the air leakage cavity is arranged on the floating rod, and a sealing member capable of closing or opening the top of the air leakage cavity is arranged on the floating rod;

[0010] A negative pressure exhaust pipe is connected to the top of the mixing tube.

[0011] By adopting the above technical solution, the mixing tube 2 moves upward, so that the through hole 1 is connected with the particle feeding pipe, and the particles enter the inside of the mixing tube 2. The mixing tube 2 moves downward, and the rotation of the mixing tube 2 is controlled by the control member, so that the through hole 1 and the through hole 2 are both closed by the inner wall of the mixing tube 1. The negative pressure exhaust pipe exhausts air from the top of the mixing tube 1, so that the solution at the bottom of the mixing tube 1 enters the inside of the mixing tube 2 through the one-way valve under the action of negative pressure. The capillary phenomenon of the liquid is utilized to promote the liquid to penetrate into the tiny pores of the porous particles more evenly and thoroughly, which helps the bubbles inside the particles to be effectively discharged, and the negative pressure environment is conducive to reducing the residual gas in the mixing tube 2. Compared with directly installing the pipeline on the mixing tube 2, the arrangement of the mixing tube 1 and the mixing tube 2 can reduce the influence of the gas in the pipeline on the solution and particles in the mixing tube 2, which is conducive to reducing the residual gas in the mixing tube 2.

[0012] As the liquid level of the solution rises, the solution passes through the opening and enters the cavity above the second mixing tube, and the floating rod gradually rises until the floating rod seals the opening and the one-way valve. The negative pressure exhaust pipe exhausts air again, and the closure opens the top of the air release chamber, allowing the gas inside the second mixing tube to enter the top of the air release chamber through the exhaust valve and be drawn upward, and the particles and solution in the second mixing tube are subjected to secondary negative pressure treatment, which is conducive to increasing the volume of the bubbles remaining in the mixing tube and then overflowing from the particles. The residual gas in the second mixing tube can be further reduced, and the negative pressure exhaust pipe is connected to the top of the first mixing tube, and the air in the second mixing tube is discharged upward by the negative pressure. This structural setting can reduce the situation where the liquid vaporizes and enters the interior of the particles after the boiling point is reduced due to the reduction in air pressure, and is also conducive to protecting the particle structure from damage, and can reduce the risk of liquid being drawn away.

[0013] After that, the driving part controls the mixing tube 2 to move upward. Due to the restriction of the one-way valve at the bottom, the mixing tube 2 and the solution located above the mixing tube 2 move upward together. The control part controls the rotation of the mixing tube 2 so that the through hole 2 can be connected with the mixture discharge pipe, and the solution and particles inside the mixing tube 2 are discharged. After the solution in the mixing tube 2 is discharged, the buoyancy decreases, the floating rod drops, and the solution originally located above the mixing tube 2 also enters the mixing tube 2 and is discharged. This process is conducive to controlling the amount of particles and solution, and the solution above the mixing tube 2 enters the mixing tube 2, which can flush the inside of the mixing tube 2 and reduce the residual particles in the mixing tube 2.

[0014] Optionally, the closing member includes a closing rod vertically slidably inserted into the top of the floating rod, a closing block is connected to the bottom of the closing rod, a closing ring is connected to the inner wall of the air release chamber, the closing block is slidably inserted into the inner wall of the closing ring, and a push spring is provided between the top wall of the air release chamber and the top surface of the closing block.

[0015] By adopting the above technical solution, before the secondary negative pressure is applied, the negative pressure exhaust pipe is used to exhaust air, and the closing rod is moved upward under the action of the pressure difference between the air pressure at the top of the mixing tube and the air pressure inside the air release chamber, until the closing block is separated from the closing ring, that is, the top of the air release chamber is opened, so that the residual gas in the mixing tube 2 can enter the top of the mixing tube 1 through the air release chamber.

[0016] Optionally, the outer edge of the top of the sealing ring is connected with a convex ring, and the inner top wall of the second mixing tube matches the convex ring and the sealing ring.

[0017] Optionally, the junction between the inner side wall of the convex ring and the top surface of the convex ring is set to be rounded.

[0018] Optionally, the particle feed pipe and the mixture discharge pipe are respectively located on both sides of mixing tube one, through hole one and through hole two are respectively located on both sides of mixing tube two, and through hole one and the particle feed pipe are located on the same radius of mixing tube one.

[0019] Optionally, the top of the mixing tube 2 is rotatably connected to the output end of the driving member, and the control member includes a sliding block which is radially slidably inserted into the side wall of the mixing tube 2 along the radial direction of the mixing tube 2, and a compression spring extending radially along the mixing tube 2 is provided between the sliding block and the mixing tube 2, and the inner wall of the mixing tube 1 is provided with a closed sliding groove consisting of a vertically extending through groove 1 and an arc-shaped through groove 2, and the sliding block is slidably inserted in the sliding groove, the depth of the top of the through groove 1 is less than the depth of the top of the through groove 2, the depth of the bottom of the through groove 1 is greater than the depth of the bottom of the through groove 2, and the inner wall of the connecting position of the through groove 1 and the through groove 2 is set to be chamfered.

[0020] By adopting the above technical solution, the compression spring pushes the sliding block. When the sliding block is located at the top of the through slot 1, due to the small depth of the top of the through slot 1, the compression spring pushes the sliding block to slide to the top of the through slot 2. Then, when the mixing tube 2 moves downward, the sliding block slides along the through slot 2. During the sliding process, the mixing tube 2 is driven to rotate around its own axis, so that the inner wall of the mixing tube 1 closes the through hole 1 and the through hole 2. Similarly, when the sliding block slides to the bottom of the through slot 2, the compression spring pushes the sliding block to enter the bottom of the through slot 1, so that the mixing tube 2 moves up along the path of the through slot 1, ensuring the connection between the through hole 1 and the through hole 2.

[0021] Optionally, the bottom wall of the through hole 1 is flush with the bottom wall of the inner cavity of the mixing tube 2.

[0022] Optionally, a connecting ring vertically penetrates the bottom of the second mixing tube, and when the bottom surface of the connecting ring is connected to the inner bottom wall of the first mixing tube, the second through hole is located below the end of the mixture discharge pipe.

[0023] In summary, the present invention includes the following beneficial technical effects:

[0024] 1. The solution at the bottom of the mixing tube 1 is allowed to enter the inside of the mixing tube 2 through the one-way valve under the action of negative pressure. The capillary phenomenon of the liquid is used to promote the liquid to penetrate into the tiny pores of the porous particles more evenly and thoroughly, which helps to effectively discharge the bubbles inside the particles. In addition, the negative pressure environment is conducive to reducing the residual gas in the mixing tube 2. Compared with directly installing the pipeline on the mixing tube 2, the setting of the mixing tube 1 and the mixing tube 2 can reduce the influence of the gas in the pipeline on the solution and particles in the mixing tube 2, which is conducive to reducing the residual gas in the mixing tube 2.

[0025] The floating rod seals the open port and the one-way valve, the negative pressure exhaust pipe exhausts air again, the sealing piece opens the top of the air release chamber, and the gas inside the second mixing tube enters the top of the air release chamber through the exhaust valve and is extracted upward, and the particles and solution in the second mixing tube are subjected to secondary negative pressure treatment, which is conducive to increasing the volume of the bubbles remaining in the mixing tube and then overflowing from the particles; this structural setting can reduce the situation where the liquid vaporizes and enters the interior of the particles after the boiling point is reduced due to the reduction of air pressure, and is also conducive to protecting the particle structure from damage, and can reduce the risk of liquid being extracted;

[0026] After the solution in the mixing tube 2 is discharged, the buoyancy decreases, the floating rod drops, and the solution originally located above the mixing tube 2 also enters the mixing tube 2 and is discharged. This process is beneficial to controlling the amount of particles and solution, and the solution above the mixing tube 2 enters the mixing tube 2, which can flush the inside of the mixing tube 2.

[0027] 2. Before the secondary negative pressure is applied, the negative pressure exhaust pipe is used to exhaust air. Under the action of the pressure difference between the air pressure at the top of the mixing tube 1 and the air pressure inside the air release chamber, the closing rod is moved upward until the closing block is separated from the closing ring, that is, the top of the air release chamber is opened, so that the residual gas in the mixing tube 2 can enter the top of the mixing tube 1 through the air release chamber.

[0028] 3. By utilizing the depth difference between through slot 1 and through slot 2, the sliding block is allowed to enter different through slots under the action of the compression spring, thereby controlling the upward and downward movement paths of the mixing tube 2, and coordinating with the positions of through hole 1 and through hole 2, that is, the opening or closing of through hole 1 and through hole 2 can be controlled, which is convenient for use. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present invention;

[0030] Figure 2 This is a schematic diagram of the overall structure of a mixing tube 1 in an embodiment of the present invention;

[0031] Figure 3 Schematic diagram of the structure of the mixing tube 1 and the mixing tube 2 in the embodiment of the present invention Figure 1 ;

[0032] Figure 4 Schematic diagram of the structure of the mixing tube 1 and the mixing tube 2 in the embodiment of the present invention Figure 2 ;

[0033] Figure 5 is a cross-sectional schematic diagram of a mixing tube 1 in an embodiment of the present invention;

[0034] Figure 6 is a cross-sectional schematic diagram of a floating rod in an embodiment of the present invention;

[0035] Figure 7 for Figure 6 A partial enlarged schematic diagram of part A.

[0036] Explanation of the accompanying drawings: 1. Filling machine body; 2. Mixing tank; 3. Mixing tube one; 31. Particle feed pipe; 32. Mixture discharge pipe; 33. Solution feed pipe; 4. Mixing tube two; 41. Through hole one; 42. Through hole two; 43. Connecting ring; 44. One-way valve; 45. Opening; 5. Driving member; 6. Control member; 61. Sliding block; 62. Sliding groove; 63. Through groove one; 64. Through groove two; 7. Floating rod; 71. Sealing block; 72. Sealing ring; 73. Air release chamber; 74. Exhaust valve; 75. Closing member; 751. Closing rod; 752. Closing block; 753. Closing ring; 754. Push spring; 76. Convex ring; 8. Negative pressure exhaust pipe. DETAILED DESCRIPTION

[0037] In order to make the purpose, technical solution and advantages of the embodiment of the present invention clearer, the technical solution of the embodiment of the present invention will be clearly and completely described below in conjunction with the drawings of the embodiment of the present invention. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0038] The following is combined with Figure 1 -Attached Figure 7 The present invention is described in further detail.

[0039] The embodiment of the present invention discloses a blood purification adsorbent pre-filling mixing device. Figures 1 to 7 A blood purification adsorbent pre-filling mixing device comprises a mixing tank 2 arranged on a filling machine body 1 and a pre-treatment component arranged on the mixing tank 2. The pre-treatment component is used to remove bubbles in the mixture of particles and solution as much as possible, and the treated mixture enters the mixing tank 2 for uniform stirring, and then enters the filling machine for filling.

[0040] Reference Figure 2 and Figure 3 The pre-treatment component includes a mixing tube 1 3, a mixing tube 2 4, a driving component 5, a control component 6, a floating rod 7 and a negative pressure exhaust pipe 8.

[0041] Reference Figure 2 and Figure 3 The mixing tube 3 is arranged vertically, and the circumferential side wall of the mixing tube 3 is connected with a particle feeding pipe 31 and a mixture discharging pipe 32, which are arranged on both sides of the mixing tube 3, respectively, and the particle feeding pipe 31 is located above the mixture discharging pipe 32. The bottom of the mixing tube 3 is connected with a solution feeding pipe 33, and the solution feeding pipe 33 is connected to the tank body to inject the solution into the mixing tube 3. The negative pressure exhaust pipe 8 is arranged at the top of the mixing tube 3 to extract the air inside the mixing tube 3 to the outside.

[0042] Reference Figure 3 , the mixing tube 2 4 is vertically slidably inserted into the inner wall of the mixing tube 1 3. The driving member 5 is arranged at the top of the mixing tube 1 3, and the linear output end of the driving member 5 extends into the inside of the mixing tube 1 3 and is rotatably connected to the top of the mixing tube 2 4. Specifically, the driving member 5 includes an electric push rod, and a slideway with an annular dovetail groove is connected to the top of the mixing tube 2 4, and the output end of the electric push rod is connected to a dovetail block matching the dovetail groove, so that the mixing tube 2 4 and the electric push rod can be rotatably connected. Further, in other embodiments, the driving member 5 can also use a linear output device such as a hydraulic push rod, and the linear output end of the linear output device can also be coaxially arranged with the mixing tube 2 4, and the output end is rotatably connected to a disc, and a plurality of circumferentially arranged connecting rods are connected below the disc, and the connecting rod is connected to the mixing tube 2 4, which can not only realize the rotation connection between the driving member 5 and the mixing tube 2 4, but also avoid the situation where the driving member 5 conflicts with other structures as much as possible. The driving member 5 controls the mixing tube 2 4 to move back and forth in the vertical direction.

[0043] It is convenient to create a negative pressure environment, and is helpful to reduce the situation where the liquid vaporizes and enters the particles after the boiling point is reduced due to the reduction of air pressure. It is also helpful to protect the particle structure from damage and reduce the risk of liquid being pumped away.

[0044] Reference Figure 3 and Figure 4 The circumferential side wall of the mixing tube 2 4 is provided with a through hole 1 41 and a through hole 2 42. The bottom walls of the through hole 1 41 and the through hole 2 42 are both inclined. The through hole 1 41 and the through hole 2 42 are respectively arranged on both sides of the mixing tube 1 3. The through hole 1 41 is located above the through hole 2 42. When the mixing tube 2 4 is located in the middle of the mixing tube 1 3, the through hole 1 41 and the through hole 2 42 are located between the end of the particle feeding tube 31 and the end of the mixture discharge tube 32. The bottom wall of the through hole 1 41 is flush with the bottom wall of the internal cavity of the mixing tube 2 4. The through hole 1 41 and the particle feeding tube 31 are located on the same radius of the mixing tube 1 3, and the through hole 2 42 and the mixture discharge tube 32 are located on the same radius of the mixing tube 1 3. At this time, if the mixing tube 2 4 moves upward, the through hole 1 41 can be connected with the end of the particle feeding tube 31; if the mixing tube 2 4 moves downward, the through hole 2 42 can be connected with the end of the mixture discharge tube 32; if the mixing tube 2 4 rotates a certain angle, then when the mixing tube 2 4 moves vertically back and forth, the through hole 1 41 and the through hole 2 42 are always closed by the inner wall of the mixing tube 1 3.

[0045] Reference Figure 3 , Figure 4 and Figure 5The control member 6 is arranged between the mixing tube 1 3 and the mixing tube 2 4. The control member 6 is used to control the mixing tube 2 4 to rotate around its own axis. In connection with the above, when the mixing tube 2 4 rotates, the through hole 1 41 and the through hole 2 42 are closed by the inner wall of the mixing tube 1 3, that is, the control member 6 can control the closing or opening of the through hole 1 41 and the through hole 2 42 through the rotation of the mixing tube 2 4.

[0046] Reference Figure 3 and Figure 5 The control member 6 includes a sliding block 61, a compression spring and a sliding groove 62. A through groove extending radially along the mixing tube 2 4 is provided on the outer side wall of the mixing tube 2 4. One end of the compression spring is fixedly connected to the side wall of the through groove, and the other end of the compression spring is fixedly connected to the sliding block 61, wherein the compression spring is not shown in the figure. The sliding block 61 is slidably inserted into the through groove, and the size of the sliding block 61 is smaller than the diameter of the through groove, so that the sliding block 61 has a certain steering flexibility. The sliding groove 62 is composed of a through groove 1 63 and a through groove 2 64. The through groove 1 63 extends vertically, and the through groove 2 64 is arc-shaped. The top of the through groove 1 63 is connected to the top of the through groove 2 64, and the bottom of the through groove 1 63 is connected to the bottom of the through groove 2 64. The end of the sliding block 61 is slidably inserted into the sliding groove 62. The depth of the top of the through slot 1 63 is less than the depth of the top of the through slot 2 64 , the depth of the bottom of the through slot 1 63 is greater than the depth of the bottom of the through slot 2 64 , and the inner wall of the connecting position of the through slot 1 63 and the through slot 2 64 is chamfered.

[0047] The compression spring pushes the sliding block 61. When the sliding block 61 is located at the top of the through slot 1 63, since the top of the through slot 1 63 is relatively deep, the compression spring pushes the sliding block 61, causing the sliding block 61 to slide to the top of the through slot 2 64. Then, when the mixing tube 2 4 moves downward, the sliding block 61 slides along the through slot 2 64, driving the mixing tube 2 4 to rotate around its own axis during the sliding process, so that the inner wall of the mixing tube 1 3 closes the through hole 1 41 and the through hole 2 42. Similarly, when the sliding block 61 slides to the bottom of the through slot 2 64, the compression spring pushes the sliding block 61, causing the sliding block 61 to enter the bottom of the through slot 1 63, so that the mixing tube 2 4 moves upward along the path of the through slot 1 63, ensuring the connection between the through hole 1 41 and the through hole 2 42. This is beneficial to controlling the rotation timing of the mixing tube 2 4. Furthermore, in other embodiments, the control member 6 may also be selected to have a structure that cooperates with the driving member 5 so that it can control both the rotation of the mixing tube 2 4 and the vertical reciprocating movement of the mixing tube 2 4, such as a combination of a rotating motor, gears, and an electric push rod.

[0048] Reference Figure 4 The bottom of the mixing tube 2 4 is connected with a connecting ring 43 which is vertically penetrated. When the bottom surface of the connecting ring 43 is connected with the bottom wall of the mixing tube 1 3 , the through hole 2 42 is located below the end of the mixture discharge pipe 32 . It is convenient to control the downward position of the mixing tube 2 4 , and it is convenient to control the opening or closing of the through hole 1 41 and the through hole 2 42 , so as to facilitate the discharge of bubbles in the mixing tube 2 4 .

[0049] Reference Figure 4 A one-way valve 44 is provided at the bottom of the mixing tube 4 to allow the solution to pass from bottom to top, and an opening 45 coaxially arranged therewith is provided at the top of the mixing tube 4.

[0050] Reference Figure 4 and Figure 6 The floating rod 7 is vertically slidably arranged inside the mixing tube 2 4, and the bottom end of the floating rod 7 passes through the bottom of the mixing tube 2 4. The bottom end of the floating rod 7 is connected to a sealing block 71 capable of closing the bottom surface of the one-way valve 44, and the circumferential side wall of the floating rod 7 is connected to a sealing ring 72 capable of closing the bottom of the opening 45. A vertically extending air leakage cavity 73 is opened inside the floating rod 7. The floating rod 7 is provided with an exhaust valve 74 capable of allowing the air inside the mixing tube 2 4 to flow unidirectionally to the inside of the air leakage cavity 73. The top of the floating rod 7 is provided with a closing piece 75 capable of closing or opening the top of the air leakage cavity 73.

[0051] The control member 6 controls the rotation of the mixing tube 2 4, so that the through hole 1 41 and the through hole 2 42 are both closed by the inner wall of the mixing tube 3, and the negative pressure exhaust pipe 8 exhausts air from the top of the mixing tube 3, so that the solution at the bottom of the mixing tube 3 enters the inside of the mixing tube 2 4 through the one-way valve 44 under the action of negative pressure. The capillary phenomenon of the liquid is utilized to promote the liquid to penetrate into the tiny pores of the porous particles more evenly and thoroughly, which helps to effectively discharge the bubbles inside the particles, and the negative pressure environment is conducive to reducing the residual gas in the mixing tube 2 4.

[0052] Reference Figure 6 The outer edge of the top of the sealing ring 72 is connected with a convex ring 76, and the inner top wall of the mixing tube 24 matches the convex ring 76 and the sealing ring 72. The inner side wall of the convex ring 76 and the top surface of the convex ring 76 are connected with a rounded corner, which is conducive to improving the sealing performance.

[0053] Reference Figure 6 and Figure 7 The closing member 75 includes a closing rod 751, a closing block 752, a closing ring 753 and a pushing spring 754. The closing rod 751 is vertically slidably inserted in the top of the air-deflating chamber 73, the closing block 752 is connected to the bottom of the closing rod 751, the outer wall of the closing ring 753 is fixedly connected to the inner wall of the air-deflating chamber 73, the closing block 752 is slidably inserted in the inner wall of the closing ring 753, and the pushing spring 754 is vertically arranged between the top wall of the air-deflating chamber 73 and the top surface of the closing block 752. It is conducive to the automation of the device. Furthermore, in other embodiments, the closing member 75 can also use a valve or the like to control the outflow of gas at the top of the air-deflating chamber 73.

[0054] As the liquid level of the solution rises, the solution passes through the opening 45 and enters the cavity above the mixing tube 2 4 , and the floating rod 7 gradually rises until the floating rod 7 seals the opening 45 and the one-way valve 44 .

[0055] The negative pressure exhaust pipe 8 exhausts air again, and under the action of the pressure difference between the air pressure at the top of the mixing tube 3 and the air pressure inside the air release chamber 73, the closing rod 751 moves upward until the closing block 752 separates from the closing ring 753, that is, the top of the air release chamber 73 is opened, so that the residual gas in the mixing tube 2 4 can enter the top of the mixing tube 3 through the air release chamber 73 and be drawn upward, and the particles and solution in the mixing tube 2 4 are subjected to secondary negative pressure treatment, which is conducive to increasing the volume of the bubbles remaining in the mixing tube and then overflowing from the particles. The residual gas in the mixing tube 2 4 can be further reduced, and the negative pressure exhaust pipe 8 is connected to the top of the mixing tube 3, and the air in the mixing tube 2 4 is discharged upward by the negative pressure. This structural setting can reduce the situation where the liquid enters the interior of the particles after the boiling point is reduced due to the reduction of air pressure, and is also conducive to protecting the particle structure from damage, and can reduce the risk of liquid being drawn away.

[0056] The implementation principle of a blood purification adsorbent pre-filling mixing device according to an embodiment of the present invention is as follows:

[0057] The mixing tube 2 4 moves upward along the path of the through groove 1 63, so that the through hole 1 41 is connected with the particle feeding tube 31, and the particles enter the inside of the mixing tube 2 4. The mixing tube 2 4 moves downward along the path of the through groove 2 64, and the through hole 1 41 and the through hole 2 42 are always closed by the inner wall of the mixing tube 3 during the movement. The mixing tube 2 4 moves downward until the bottom surface of the connecting ring 43 is connected to the bottom of the inner wall of the mixing tube 3. At this time, the through hole 2 42 is located below the end of the mixture discharge pipe 32, and the negative pressure exhaust pipe 8 exhausts air from the top of the mixing tube 3, so that the solution at the bottom of the mixing tube 3 enters the inside of the mixing tube 2 4 through the one-way valve 44 under the action of negative pressure. The capillary phenomenon of the liquid is used to promote the liquid to penetrate into the tiny pores of the porous particles more evenly and thoroughly, which helps the bubbles inside the particles to be effectively discharged.

[0058] As the liquid level of the solution rises, the solution passes through the opening 45 and enters the cavity above the mixing tube 2 4, and the floating rod 7 gradually rises until the floating rod 7 seals the opening 45 and the one-way valve 44. The negative pressure exhaust pipe 8 exhausts air again, and under the action of the pressure difference between the air pressure at the top of the mixing tube 1 3 and the air pressure inside the air release chamber 73, the closing rod 751 moves upward until the closing block 752 is separated from the closing ring 753, that is, the top of the air release chamber 73 is opened, and the particles and the solution in the mixing tube 2 4 are subjected to secondary negative pressure treatment, which is conducive to increasing the volume of the bubbles remaining in the mixing tube and overflowing from the particles, and allowing the residual gas in the mixing tube 2 4 to enter the top of the mixing tube 1 3 through the air release chamber 73 and then be extracted.

[0059] The driving member 5 controls the mixing tube 2 4 to move upward, and the mixing tube 2 4 moves along the path of the through groove 1 63. Due to the restriction of the bottom one-way valve 44, the mixing tube 2 4 and the solution located above the mixing tube 2 4 move upward together, and the through hole 2 42 is connected to the mixture discharge pipe 32. The mixture inside the mixing tube 2 4 flows into the mixing tank 2 for stirring. The stirring process adopts a stirring method that can minimize the generation of bubbles. Since this method belongs to the technical content well known to technical personnel in this field, the specific stirring device will not be described in detail here. Since the bubble removal treatment has been carried out before entering the mixing tank 2, there is no need to be still after stirring, which can improve production efficiency and is conducive to the uniform distribution of particles in the solution.

[0060] After the solution in the mixing tube 2 4 is discharged, the buoyancy is reduced, the floating rod 7 drops, and the solution originally located above the mixing tube 2 4 also enters the mixing tube 2 4 and is discharged. This process is conducive to controlling the amount of particles and solution, and the solution above the mixing tube 2 4 enters the mixing tube 2 4, which can flush the inside of the mixing tube 2 4.

[0061] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0062] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A mixing device before filling of a blood purification adsorbent, comprising a mixing tube 1 whose circumferential side wall is connected with a particle feed pipe and a mixture discharge pipe in sequence from top to bottom and a mixing tube 1 whose bottom is connected with a solution feed pipe, characterized in that: Also includes: A mixing tube 2 is vertically slidably inserted into the inner wall of the mixing tube 1 and a driving member for driving the mixing tube 2 to reciprocate vertically. The circumferential side wall of the mixing tube 2 is provided with a through hole 1 and a through hole 2 which are arranged in sequence in the vertical direction and are arranged between the particle feeding pipe and the mixture discharging pipe. A control member for controlling the mixing tube 2 to rotate around its own axis is provided between the mixing tube 1 and the mixing tube 2. A one-way valve that allows the solution to pass from bottom to top is provided at the bottom of the mixing tube 2. An opening coaxially arranged therewith is provided at the top of the mixing tube 2. A floating rod is vertically slidably arranged inside the second mixing tube, the bottom end of the floating rod passes through the bottom of the second mixing tube and is connected to a sealing block capable of closing the bottom surface of the one-way valve, the circumferential side wall of the floating rod is connected to a sealing ring capable of closing the open bottom, a vertically extending air leakage cavity is opened inside the floating rod, an exhaust valve capable of allowing the air inside the second mixing tube to flow unidirectionally into the air leakage cavity is arranged on the floating rod, and a sealing member capable of closing or opening the top of the air leakage cavity is arranged on the floating rod; A negative pressure exhaust pipe is connected to the top of the mixing tube.

2. A blood purification adsorbent pre-filling mixing device according to claim 1, characterized in that: The closing piece includes a closing rod vertically slidably inserted into the top of the floating rod, a closing block is connected to the bottom of the closing rod, a closing ring is connected to the inner wall of the air release cavity, the closing block is slidably inserted into the inner wall of the closing ring, and a pushing spring is provided between the top wall of the air release cavity and the top surface of the closing block.

3. A blood purification adsorbent pre-filling mixing device according to claim 1, characterized in that: The outer edge of the top of the sealing ring is connected with a convex ring, and the inner top wall of the second mixing tube matches the convex ring and the sealing ring.

4. A blood purification adsorbent pre-filling mixing device according to claim 3, characterized in that: The junction between the inner side wall of the convex ring and the top surface of the convex ring is set as a rounded corner.

5. A blood purification adsorbent pre-filling mixing device according to claim 1, characterized in that: The particle feeding pipe and the mixture discharging pipe are respectively located on both sides of the mixing pipe 1, the through hole 1 and the through hole 2 are respectively located on both sides of the mixing pipe 2, and the through hole 1 and the particle feeding pipe are located on the same radius of the mixing pipe 1.

6. A blood purification adsorbent pre-filling mixing device according to claim 5, characterized in that: The top of the second mixing tube is rotatably connected to the output end of the driving member, and the control member includes a sliding block which is inserted into the side wall of the second mixing tube for radial sliding sliding along the second mixing tube, and a compression spring extending radially along the second mixing tube is provided between the sliding block and the second mixing tube. The inner wall of the first mixing tube is provided with a closed sliding groove consisting of a vertically extending through groove 1 and an arc-shaped through groove 2, and the sliding block is slidably inserted into the sliding groove, the depth of the top of the through groove 1 is less than the depth of the top of the through groove 2, the depth of the bottom of the through groove 1 is greater than the depth of the bottom of the through groove 2, and the inner wall of the position where the through groove 1 and the through groove 2 are connected is set to be chamfered.

7. A blood purification adsorbent pre-filling mixing device according to claim 6, characterized in that: The bottom wall of the first through hole is flush with the bottom wall of the inner cavity of the second mixing tube.

8. A blood purification adsorbent pre-filling mixing device according to claim 7, characterized in that: The bottom of the second mixing tube is connected with a connecting ring which is vertically penetrated. When the bottom surface of the connecting ring is connected with the inner bottom wall of the first mixing tube, the second through hole is located below the end of the mixture discharge tube.

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