Whitening and freckle-removing face cream and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further relates to whitening and freckle removing face cream and a preparation method thereof. The whitening and freckle-removing mask is prepared from the following raw materials: a whitening and freckle-removing composition, an emollient, a humectant, an emulsifier, a light stabilizer, a preservative, a thickener, essence, EDTA-2Na and water. The whitening and freckle-removing composition at least comprises nicotinamide and a plant extract containing a flavone component. According to the face cream, through the synergistic effect of the nicotinamide, the plant extract containing the flavone component, the resorcinol derivative, the vitamin E and the soothing composition, whitening and freckle removing are achieved from multiple dimensions, and meanwhile the problem of compatibility among the raw materials is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further to a whitening and freckle-removing cream and a preparation method thereof. Background Art

[0002] Melanin deposits in the epidermis or dermis to form spots. As everyone loves beauty, more and more people begin to pay attention to the use of spot removal products. Currently, the spot removal mechanism of spot removal products on the market is relatively simple. In order to achieve a better spot removal effect, higher concentrations of whitening ingredients are often used. In order to solve the above problems, Chinese patent CN 201910682774 discloses a whitening and moisturizing essence and a whitening and moisturizing facial mask prepared using the same. The whitening and moisturizing essence is composed of the following raw materials and their mass percentages: 5% to 15% natural plant extract, 5% to 10% glycerin, 2% to 5% sodium hyaluronate, 5% to 7% niacinamide, 2% to 4% hydroxyethyl cellulose, 0.4% to 0.6% p-hydroxyacetophenone, 0.5% to 1% polyacrylic acid, 0.05% to 0.1% citric acid, 0.1% to 0.5% hydrogenated castor oil, and the remainder is deionized water. The total mass percentage of the raw materials is recorded as 100%. This technical solution reduces the irritation of niacinamide like the natural plant extract, but its mechanism of action is relatively single and the concentration of niacinamide is relatively high, which may pose certain risks to sensitive skin. Summary of the invention

[0003] In order to solve the above technical problems, the first aspect of the present invention provides a whitening and freckle-removing facial cream, the raw materials of which include a whitening and freckle-removing composition, a moisturizer, a humectant, an emulsifier, a light stabilizer, a preservative, a thickener, a flavor, EDTA-2Na, and water; the whitening and freckle-removing composition includes at least niacinamide and a plant extract containing flavonoid components.

[0004] Preferably, the whitening and freckle-removing cream comprises, by mass percentage, 5-15% of the whitening and freckle-removing composition, 5-15% of an emollient, 5-12% of a moisturizer, 5-10% of an emulsifier, 0.1-0.6% of a light stabilizer, 0.1-0.6% of a preservative, 0.05-0.5% of a thickener, 0.01-0.1% of lactic acid, 0.01-0.1% of an essence, 0.01-0.1% of EDTA-2Na, and the remainder made up of water; the whitening and freckle-removing composition comprises at least niacinamide and a plant extract containing flavonoid components.

[0005] Preferably, the nicotinic acid content in the nicotinamide is less than 100 ppm.

[0006] Preferably, the nicotinic acid content in the nicotinamide is less than 50 ppm.

[0007] Preferably, the plant extract containing flavonoid components includes at least one of Platycladus orientalis leaf extract, Paeonia lactiflora root extract, Ginkgo biloba leaf extract and Chrysanthemum extract.

[0008] Preferably, the plant extract containing flavonoid components includes at least peony root extract and ginkgo leaf extract.

[0009] Preferably, the plant extract containing flavonoid components is water, butylene glycol, peony root extract, ginkgo leaf extract, and 1,2-hexanediol.

[0010] In order to reduce the irritation of niacinamide, the niacin content in the niacinamide introduced in the present application is less than 50ppm. At the same time, a plant extract containing flavonoid components is introduced in the present application, which can further improve the whitening and freckle removal effects while avoiding the problem of niacinamide decomposing niacin at high temperatures, thereby further avoiding the irritation of the cream.

[0011] Preferably, the whitening and freckle-removing composition further comprises at least one of a resorcinol derivative, vitamin E, and a soothing composition.

[0012] Preferably, the whitening and freckle-removing composition further comprises a resorcinol derivative, vitamin E, and a soothing composition.

[0013] Preferably, the resorcinol derivative includes at least one of phenethyl resorcinol, hexyl resorcinol and 4-butyl resorcinol.

[0014] Preferably, the resorcinol derivative includes at least 4-butylresorcinol.

[0015] Preferably, the resorcinol derivative is water, polyglycerol-10 oleate, caprylic acid, capric triglyceride, 4-butylresorcinol, cocoyl glucoside, glycerol, propylene glycol, butylene glycol, isononyl isononanoate, phosphatidylcholine, tocopherol acetate, and lactose.

[0016] Preferably, the soothing composition comprises at least one of madecassoside, β-glucan, bisabolol, and hydroxyphenylpropionamide benzoic acid.

[0017] Preferably, the soothing composition comprises at least hydroxyphenylpropionamide benzoic acid.

[0018] Preferably, the soothing composition is butylene glycol, 1,2-pentanediol, and hydroxyphenylpropionamide benzoic acid.

[0019] Preferably, the mass ratio of the niacinamide, the plant extract containing flavonoid components, the resorcinol derivative, vitamin E, and the soothing composition is (2-4): (0.5-1.5): (2-5): (0.2-1): (0.5-1.5).

[0020] Preferably, the mass ratio of niacinamide, the plant extract containing flavonoid components, the resorcinol derivative, vitamin E, and the soothing composition is (3-3.5): (0.8-1.2): (3-4): (0.3-0.6): (0.8-1.2).

[0021] Preferably, the mass ratio of the niacinamide, the plant extract containing flavonoid components, the resorcinol derivative, vitamin E, and the soothing composition is 3.5:1:4:0.5:1.

[0022] In order to achieve the whitening and freckle removal effects from multiple aspects, the applicant further introduced resorcinol derivatives, vitamin E, and a soothing composition on the basis of niacinamide and a plant extract containing flavonoid components. However, the applicant found that there was a problem with the compatibility of the system and the obtained cream showed stratification. When the mass ratio of niacinamide, a plant extract containing flavonoid components, resorcinol derivatives, vitamin E, and a soothing composition was controlled to be (3-3.5): (0.8-1.2): (3-4): (0.3-0.6): (0.8-1.2), the above problems could be solved and the cream could also be stably present at high temperatures without oil separation or discoloration. The applicant It is speculated that when the mass ratio of niacinamide, plant extract containing flavonoid components, resorcinol derivatives, vitamin E, and soothing composition is not within the range of (3-3.5): (0.8-1.2): (3-4): (0.3-0.6): (0.8-1.2), the compatibility balance of the system is affected because the niacinamide in the present application is weakly alkaline and the resorcinol derivatives are weakly acidic; when within the specified range, the presence of the plant extract containing flavonoid components and the soothing composition in the system can prevent the resorcinol derivatives and vitamin E from being unstable at high temperatures and discoloring, and can also prevent the decomposition of niacinamide at high temperatures.

[0023] Preferably, the emollient is selected from at least two of caprylic / capric triglyceride, cyclopolydimethylsiloxane, squalane, isononyl isononanoate, and jojoba oil.

[0024] Preferably, the emollients are caprylic / capric triglyceride, cyclopolydimethylsiloxane and squalane; the mass ratio of caprylic / capric triglyceride, cyclopolydimethylsiloxane and squalane is (4-6): (2-4): (1-3).

[0025] Preferably, the mass ratio of caprylic / capric triglyceride, cyclopolydimethylsiloxane and squalane is 5:3:2.

[0026] Preferably, the moisturizing agent is selected from at least two of glycerin, betaine, 1,3-butylene glycol, allantoin, trehalose, and sodium hyaluronate.

[0027] Preferably, the moisturizing agent is glycerol, betaine, 1,3-butylene glycol and allantoin; the mass ratio of glycerol, betaine, 1,3-butylene glycol and allantoin is (2-4): (1-3): (4-6): (0.1-0.3).

[0028] Preferably, the mass ratio of glycerol, betaine, 1,3-butylene glycol and allantoin is 3:2:5:0.2.

[0029] Preferably, the emulsifier includes emulsifier A and emulsifier B; the mass ratio of emulsifier A to emulsifier B is (6-8):(1-2).

[0030] Preferably, the mass ratio of emulsifier A to emulsifier B is 7:1.2.

[0031] Preferably, the emulsifier A is selected from at least two of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate, and cetearyl alcohol.

[0032] Preferably, the emulsifier A is cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol; the mass ratio of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol is (1-3):(1-3):(2-4).

[0033] Preferably, the mass ratio of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol is 2:2:3.

[0034] Preferably, the emulsifier B is polyacrylamide / C13-14 isoparaffin / laureth-7.

[0035] Preferably, the light stabilizer is ethylhexyl methoxycinnamate.

[0036] Preferably, the preservative includes preservative A and preservative B; the mass ratio of preservative A to preservative B is 0.25:0.3.

[0037] Preferably, the preservative A is methylparaben, ethylparaben and butylated hydroxytoluene; the mass ratio of methylparaben, ethylparaben and butylated hydroxytoluene is 0.15:0.05:0.05.

[0038] Preferably, the preservative B is phenoxyethanol.

[0039] Preferably, the thickener is selected from at least one of xanthan gum, carbomer and isohexadecane.

[0040] Preferably, the thickener is xanthan gum.

[0041] The second aspect of the present invention provides a method for preparing a whitening and anti-freckle cream, comprising the following steps:

[0042] S1. Place emulsifier A, emollient, light stabilizer, vitamins, and preservative A in an oil pan and heat to 80-90° C. at a stirring speed of 25-35 r / min until completely dissolved to obtain an oil phase;

[0043] S2, placing EDTA-2Na, thickener, humectant, niacinamide and deionized water in a water pot and heating to 80-90°C under a stirring speed of 25-35 r / min until completely dissolved to obtain an aqueous phase;

[0044] S3. Turn on the vacuum pump switch, draw the vacuum degree in the emulsifying pot to below -0.04MPa, and adjust the stirring speed to 15-25r / min; first draw the water phase into the emulsifying pot, keep the temperature at 80-90℃ and defoam at a stirring speed of 55-65r / min, and then draw the oil phase; keep the temperature at 80-90℃ and homogenize for 5min; turn on the cooling water to cool down to 80℃, add emulsifier B, and homogenize for 3min; keep the temperature at 80℃ and defoam at a stirring speed of 25-35r / min; after defoaming, turn on the cooling water and cool down at a stirring speed of 25-35r / min;

[0045] S4, cool down to 75℃ and evacuate to -0.04MPa;

[0046] S5. Add lactic acid and resorcinol derivatives at 60° C. and stir evenly at a stirring speed of 15 to 25 r / min;

[0047] S6. Add preservative B, essence, plant extract containing flavonoid components, and soothing composition at 45° C. and stir evenly;

[0048] S7. Vacuum filter the material at 38°C to obtain the product.

[0049] Beneficial effects:

[0050] 1. The nicotinic acid content in the niacinamide introduced in the present application is less than 50 ppm. At the same time, a plant extract containing flavonoid components is introduced in the present application, which can further improve the whitening and freckle removal effect while avoiding the problem of niacin decomposition by niacinamide at high temperature, and further avoid the irritation of the cream.

[0051] 2. When the mass ratio of niacinamide, plant extract containing flavonoid components, resorcinol derivatives, vitamin E and soothing composition is controlled to be (3-3.5): (0.8-1.2): (3-4): (0.3-0.6): (0.8-1.2), the system compatibility can be solved and the system can exist stably at high temperature without oil separation or discoloration.

[0052] 3. In the present application, when the moisturizing agents are glycerin, betaine, 1,3-butylene glycol and allantoin; and the mass ratio of glycerin, betaine, 1,3-butylene glycol and allantoin is (2-4):(1-3):(4-6):(0.1-0.3), it can not only improve the moisturizing property of the whitening and anti-freckle cream, but also improve the emulsifying property of the system and improve the compatibility of the whitening and anti-freckle cream. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 The test materials and methods for the whitening and freckle-removing efficacy of the whitening and freckle-removing cream prepared in Example 1.

[0054] Figure 2 These are the test results of ITA° and MI of the whitening and anti-freckle cream prepared in Example 1.

[0055] Figure 3 This is the test result of the visual skin color grade of the whitening and anti-freckle cream prepared in Example 1.

[0056] Figure 4 It is the test results of ITA° and MI for negative control.

[0057] Figure 5 The results of visual skin color rating for negative control.

[0058] Figure 6 It is the test results of ITA° and MI for positive control.

[0059] Figure 7 The test results of visual skin color grade for positive control.

[0060] Figure 8 The difference at any time point before and after application of the whitening and anti-freckle cream prepared in Example 1 was compared with the negative control.

[0061] Fig. 9 The effective number and effectiveness rate of the whitening and anti-freckle cream prepared in Example 1 compared with the negative control. DETAILED DESCRIPTION

[0062] Example 1

[0063] Embodiment 1 provides a whitening and freckle-removing facial cream. The raw materials include, by mass percentage, 10% of a whitening and freckle-removing composition, 10% of an emollient, 10.2% of a moisturizer, 8.2% of an emulsifier, 0.5% of a light stabilizer, 0.55% of a preservative, 0.1% of a thickener, 0.05% of lactic acid, 0.06% of an essence, 0.03% of EDTA-2Na, and the balance made up of water.

[0064] The whitening and freckle-removing composition comprises niacinamide, a plant extract containing flavonoid components, a resorcinol derivative, vitamin E and a soothing composition.

[0065] The mass ratio of the niacinamide, the plant extract containing flavonoid components, the resorcinol derivative, vitamin E, and the soothing composition is 3.5:1:4:0.5:1.

[0066] The nicotinic acid content in the nicotinamide is less than 50 ppm.

[0067] The plant extract containing flavonoid components is water, butylene glycol, peony root extract, ginkgo leaf extract, and 1,2-hexanediol; it was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd., model: NB-318.

[0068] The resorcinol derivatives are water, polyglycerol-10 oleate, caprylic acid, capric triglyceride, 4-butylresorcinol, cocoyl glucoside, glycerol, propylene glycol, butylene glycol, isononyl isononanoate, phosphatidylcholine, tocopherol acetate, and lactose; purchased from Guangzhou Fanhai Fine Chemical Co., Ltd. Model: NB-980.

[0069] The soothing composition is butylene glycol, 1,2-pentanediol, and hydroxyphenylpropionamide benzoic acid; it was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd. Model: NB-325.

[0070] The emollients are caprylic / capric triglyceride, cyclopolydimethylsiloxane and squalane; the trade name of caprylic / capric triglyceride is Hicos GTC, purchased from Guangzhou Sacco Trading Co., Ltd.; the trade name of cyclopolydimethylsiloxane is DC345.

[0071] The mass ratio of caprylic / capric triglyceride, cyclopolydimethylsiloxane and squalane is 5:3:2.

[0072] The moisturizers are glycerin, betaine, 1,3-butylene glycol and allantoin; the betaine is purchased from Guangzhou Fanhai Fine Chemical Co., Ltd. Model: NB-310.

[0073] The mass ratio of the glycerol, betaine, 1,3-butylene glycol and allantoin is 3:2:5:0.2.

[0074] The emulsifier includes emulsifier A and emulsifier B; the mass ratio of emulsifier A to emulsifier B is 7:1.2.

[0075] The emulsifier A is cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol; the trade name of the cetearyl glucoside / sorbitan olivate is EMULPHARMA 1000; the trade name of the glyceryl stearate / PEG-100 stearate is 165.

[0076] The mass ratio of the cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol is 2:2:3.

[0077] The emulsifier B is polyacrylamide / C13-14 isoparaffin / laureth-7, with the trade name of 305.

[0078] The light stabilizer is ethylhexyl methoxycinnamate; the trade name is OMC, purchased from Guangzhou Sacco Trading Co., Ltd.

[0079] The preservatives include preservative A and preservative B; the mass ratio of preservative A to preservative B is 0.25:0.3.

[0080] The preservative A is methylparaben, ethylparaben and butylated hydroxytoluene; the mass ratio of methylparaben, ethylparaben and butylated hydroxytoluene is 0.15:0.05:0.05.

[0081] The preservative B is phenoxyethanol.

[0082] The thickener is xanthan gum.

[0083] A method for preparing a whitening and freckle-removing facial cream comprises the following steps:

[0084] S1. Place emulsifier A, emollient, light stabilizer, vitamins, and preservative A in an oil pan and heat to 85° C. at a stirring speed of 30 r / min until completely dissolved to obtain an oil phase;

[0085] S2, placing EDTA-2Na, thickener, humectant, niacinamide and deionized water in a water pot and heating to 85°C under a stirring speed of 30 r / min until completely dissolved to obtain an aqueous phase;

[0086] S3. Turn on the vacuum pump switch, draw the vacuum degree in the emulsifying pot to below -0.04MPa, and adjust the stirring speed to 20r / min; first draw the water phase into the emulsifying pot, keep the temperature at 85℃ and defoam at a stirring speed of 60r / min, and then draw the oil phase; keep the temperature at 85℃ and homogenize for 5min; turn on the cooling water to cool down to 80℃, add emulsifier B, and homogenize for 3min; keep the temperature at 80℃ and defoam at a stirring speed of 30r / min; after defoaming, turn on the cooling water and cool down at a stirring speed of 30r / min;

[0087] S4, cool down to 75℃ and evacuate to -0.04MPa;

[0088] S5. Add lactic acid and resorcinol derivative at 60° C. and stir evenly at a stirring speed of 20 r / min;

[0089] S6. Add preservative B, essence, plant extract containing flavonoid components, and soothing composition at 45° C. and stir evenly;

[0090] S7. Vacuum filter the material at 38°C to obtain the product.

[0091] Performance Test:

[0092] 1. Physical stability:

[0093] (1) Cold resistance: Referring to the standard GB / T29665-2013, the whitening and anti-freckle cream prepared in Examples 1 to 4 was placed at -8±2°C for 24 h. If no stratification of the product was observed after returning to room temperature, the cold resistance was recorded as "qualified"; if stratification of the product was observed after returning to room temperature, the cold resistance was recorded as "unqualified".

[0094] (2) Heat resistance: Referring to standard GB / T29665-2013, the whitening and anti-freckle cream prepared in Examples 1 to 4 was placed at 40±2°C for 24 h. If no stratification, oil separation or discoloration of the product was observed after returning to room temperature, the heat resistance was recorded as "qualified"; if stratification, oil separation or discoloration of the product was observed after returning to room temperature, the heat resistance was recorded as "unqualified".

[0095] The results are as follows:

[0096] Example 1 cold resistance qualified Heat resistance qualified

[0097] 2. Whitening and freckle removal efficacy test:

[0098] Test materials and methods are shown in Figure 1 (Test product: the original cosmetic final product refers to the whitening and anti-freckle cream prepared in Example 1 of the present application);

[0099] Test product test results see Figure 2 and Figure 3 ;

[0100] Negative control test results are shown in Figure 4 and Figure 5 ;

[0101] The positive control test results are shown in Figure 6 and Figure 7 ;

[0102] The results of the difference between the test product and the negative control at any time point before and after application are shown in Figure 8 ;

[0103] The effective number and efficacy of the test product compared with the negative control are shown in Fig. 9 .

Claims

1. A whitening and freckle removing cream, characterized in that: The raw materials include a whitening and freckle-removing composition, a moisturizer, a humectant, an emulsifier, a light stabilizer, a preservative, a thickener, an essence, EDTA-2Na, and water; the whitening and freckle-removing composition includes at least niacinamide and a plant extract containing flavonoid components.

2. The whitening and anti-freckle cream according to claim 1, characterized in that: Calculated by mass percentage, the raw materials include 5-15% of the whitening and freckle-removing composition, 5-15% of an emollient, 5-12% of a moisturizer, 5-10% of an emulsifier, 0.1-0.6% of a light stabilizer, 0.1-0.6% of a preservative, 0.05-0.5% of a thickener, 0.01-0.1% of lactic acid, 0.01-0.1% of an essence, 0.01-0.1% of EDTA-2Na, and the balance is supplemented by water; the whitening and freckle-removing composition includes at least niacinamide and a plant extract containing flavonoid components.

3. The whitening and anti-freckle cream according to claim 1 or 2, characterized in that: The plant extract containing flavonoid components includes at least one of Platycladus orientalis leaf extract, Paeonia lactiflora root extract, Ginkgo biloba leaf extract and Chrysanthemum extract.

4. The whitening and anti-freckle cream according to claim 3, characterized in that: The whitening and freckle-removing composition further comprises at least one of a resorcinol derivative, vitamin E, and a soothing composition.

5. The whitening and anti-freckle cream according to claim 4, characterized in that: The resorcinol derivative includes at least one of phenethyl resorcinol, hexyl resorcinol and 4-butyl resorcinol.

6. The whitening and anti-freckle cream according to claim 5, characterized in that: The soothing composition comprises at least one of madecassoside, beta-glucan, bisabolol and hydroxyphenylpropionamide benzoic acid.

7. The whitening and anti-freckle cream according to claim 6, characterized in that: The mass ratio of the niacinamide, the plant extract containing flavonoid components, the resorcinol derivative, vitamin E, and the soothing composition is (2-4): (0.5-1.5): (2-5): (0.2-1): (0.5-1.5).

8. The whitening and anti-freckle cream according to claim 7, characterized in that: The mass ratio of the niacinamide, the plant extract containing flavonoid components, the resorcinol derivative, vitamin E, and the soothing composition is (3-3.5): (0.8-1.2): (3-4): (0.3-0.6): (0.8-1.2).

9. The whitening and anti-freckle cream according to claim 1, characterized in that: The moisturizing agent is selected from at least two of glycerin, betaine, 1,3-butylene glycol, allantoin, trehalose, and sodium hyaluronate.

10. A method for preparing a whitening and anti-freckle cream according to any one of claims 1 to 9, characterized in that: The following steps are involved: Mix the raw materials evenly.

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