A traditional Chinese medicine composition for improving facial red blood vessels, an extract, a preparation method and applications thereof

Abstract

The application discloses a traditional Chinese medicine composition for improving facial red blood vessels, an extract, and a preparation method and application thereof. The traditional Chinese medicine composition is composed of Leonurus japonicus and Corydalis remota. The traditional Chinese medicine composition is subjected to water extraction, and butanediol is selectively added to obtain the extract for improving facial red blood vessels. The traditional Chinese medicine composition or the extract can significantly improve facial red blood vessels, has no adverse reaction, is low in cost, and provides another way for improving facial red blood vessels for users with individual differences.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for improving facial red blood streaks, an extract thereof, and a preparation method and application thereof. Background Art

[0002] Facial redness is caused by decreased elasticity and increased fragility of facial capillary walls, leading to persistent, uneven dilation and even rupture of blood vessels. In severe cases, this can also trigger vascular proliferation, resulting in facial redness and dilated capillaries, often accompanied by red or purple-red patches, dots, lines, or star-shaped appearances. Left untreated, facial redness can not only increase skin sensitivity, causing burning, itching, and stinging, but also damage the skin barrier, making it more susceptible to external factors and free radicals, and accelerating the aging process. Long-standing facial redness can also increase the skin's susceptibility to infection by bacteria and other pathogens, leading to skin inflammation and other skin diseases. This not only affects the skin's appearance but can also lead to low self-esteem, seriously impacting a person's confidence and mental health.

[0003] Currently, the main treatments for red blood streaks in China and abroad rely on physical methods, such as laser therapy. Laser therapy uses the principle of selective photothermolysis to target hemoglobin within diseased blood vessels, causing them to thermally decompose, absorb, and ultimately disappear. However, laser therapy is often painful, and improper treatment may lead to edema or residual dark spots. Furthermore, laser therapy is expensive and is suitable for a limited population. Topical cosmetic treatments primarily focus on soothing the skin. Currently, only a few French cosmeceuticals companies have launched cosmetics targeting red blood streaks, but the effectiveness of these products is still affected by individual differences.

[0004] Traditional Chinese Medicine (TCM) has long practiced facial conditioning methods. However, due to individual differences, some herbal formulas may cause allergic reactions or be ineffective during use, necessitating a greater variety and experimentation to meet the needs of diverse populations. In TCM, facial redness is considered "face redness" or "facial erythema," often associated with pathological factors such as blood heat, blood stasis, and qi deficiency. TCM believes that facial redness is caused by yin deficiency, blood heat, insufficient body fluids and blood, and stagnation in the blood vessels. This leads to malnutrition and dryness of the skin, which in turn accelerates keratinization, thinning of the skin, and the appearance of a red face. Summary of the Invention

[0005] The primary purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art and provide a Chinese medicine composition for improving facial redness.

[0006] Another object of the present invention is to provide an extract for improving facial redness and a preparation method thereof.

[0007] Another object of the present invention is to provide an application of the above-mentioned Chinese medicine composition or extract for improving facial redness.

[0008] The purpose of the present invention is achieved through the following technical scheme: a traditional Chinese medicine composition for improving facial red blood streaks, composed of the following ingredients in parts by mass: 25-40 parts of motherwort and 5-15 parts of corydalis dentata.

[0009] A method for preparing an extract for improving facial redness is to extract the above-mentioned Chinese medicine composition with water; preferably, the method comprises the following steps:

[0010] (1) extracting the above-mentioned Chinese herbal composition for improving facial redness with water, separating the solid and the liquid, and taking the liquid;

[0011] (2) The liquid obtained in step (1) is further clarified to obtain an extract.

[0012] In order to make the obtained extract more stable, the above preparation method further comprises the following steps:

[0013] (3) Add polyol and water to the extract and mix well to obtain an extract for improving facial redness.

[0014] The water described in step (1) is preferably softened water.

[0015] The amount of water used in step (1) is 6 to 10 times the mass of the traditional Chinese medicine composition.

[0016] The extraction in step (1) is carried out at room temperature.

[0017] The room temperature is 10-40°C, preferably 20-30°C, and more preferably 24-26°C.

[0018] The extraction time in step (1) is preferably 0.5 to 3 hours.

[0019] The solid-liquid separation method in step (1) is preferably filtration.

[0020] The clarification method in step (2) is preferably centrifugation.

[0021] The polyol described in step (3) is preferably butanediol.

[0022] The amount of the polyol in step (3) is preferably calculated based on the polyol being 1.5 to 2.5 times the mass of the traditional Chinese medicine composition; more preferably, the amount of the polyol is calculated based on the polyol being 1.6 to 2.2 times the mass of the traditional Chinese medicine composition.

[0023] The water described in step (3) is preferably ultrapure water.

[0024] The amount of water in step (3) is preferably calculated based on the mass of water being 2 to 4 times the mass of the traditional Chinese medicine composition; more preferably, the amount of water is calculated based on the mass of the polyol being 2.3 to 3.5 times the mass of the traditional Chinese medicine composition.

[0025] An extract for improving facial red blood streaks is obtained by the above preparation method.

[0026] Application of the above-mentioned traditional Chinese medicine composition for improving facial redness or extract for improving facial redness in the preparation of skin care products for improving facial redness.

[0027] A skin care product for improving facial redness, comprising the extract for improving facial redness; preferably comprising the following ingredients in percentage by mass: 0.05% EDTA-2Na, 0.5% silicone wax DC2501, 0.3% cinnamone, 4% hydroxyethyl urea, 0.02% sarin resin PC2000, 2% of the extract for improving facial redness, 0.3% hydroxyethyl cellulose, 0.03% sodium hyaluronate, 5% glycerin, 0.02% fragrance, 0.1% HPS, 1% 1,3-propylene glycol, and 0.15% PE9010.

[0028] The skin care product for improving facial redness also contains water, with the water being the balance.

[0029] The method for preparing the above-mentioned skin care product for improving facial redness comprises the following steps:

[0030] 1) Mix EDTA-2Na, silicone wax DC2501, cinnamone, hydroxyethyl urea, sarin resin PC2000, the extract for improving facial redness, and water, and heat to 75-80°C while stirring to obtain phase A;

[0031] 2) Combine hydroxyethyl cellulose, sodium hyaluronate, glycerin, and flavor, stirring until there are no fine particles to obtain Phase B. Add Phase B to Phase A, mix well, and keep warm at 75-80°C until completely dissolved.

[0032] 3) Mix HPS, 1,3-propylene glycol, and water to obtain phase C;

[0033] 4) The product finally obtained in step 2) is cooled to 40-42° C., phase C and PE9010 are added, stirred evenly, and filtered to obtain a skin care product for improving facial redness.

[0034] The stirring speed in step 1) is preferably 40 to 60 rpm.

[0035] The gauze used in the filtration described in step 4) is 200 mesh gauze.

[0036] The present invention has the following advantages and effects compared to the prior art:

[0037] Based on the Traditional Chinese Medicine (TCM) concept of "promoting blood circulation, removing blood stasis, cooling blood, and reducing swelling," Leonurus japonicus and Corydalis yanhusuo are combined. Leonurus japonicus promotes blood circulation, removes blood stasis, cools blood, and reduces swelling; while Corydalis yanhusuo promotes blood circulation, removes blood stasis, promotes qi circulation, relieves pain, and unclogs blood vessels. The combined formula effectively promotes blood circulation, removes blood stasis, unclogs blood vessels, cools blood, reduces swelling, and regulates facial redness. The present invention provides a traditional Chinese medicine composition that can significantly improve facial redness. This traditional Chinese medicine composition has no adverse reactions, is low-cost, and provides an alternative approach to improving facial redness for users with individual differences. DETAILED DESCRIPTION

[0038] The present invention will be further described in detail below with reference to the examples, but the embodiments of the present invention are not limited thereto.

[0039] Example 1

[0040] Weigh 32 parts by weight of Leonurus japonicus and 8 parts by weight of Corydalis serrulata and add them to 8 times the total weight of the herbs in softened water. Soak and extract at room temperature for 1 hour. After extraction, filter through a 100-mesh filter for solid-liquid separation. Centrifuge the separated liquid (8000 rpm) to remove most particles. Add 80 parts by weight of butylene glycol and 116 parts by weight of ultrapure water to the centrifuged liquid. Stir thoroughly and filter through a 0.22 μm microporous membrane to obtain an extract that improves facial redness.

[0041] Example 2

[0042] The difference between Example 2 and Example 1 is that the ratio and extraction conditions of the Chinese medicine composition are adjusted.

[0043] Weigh 40 parts by weight of Leonurus japonicus and 15 parts by weight of Corydalis yanhusuo and add them to softened water (10 times the total weight of the herbs). Extract the mixture at room temperature for 3 hours. After extraction, filter through a 100-mesh filter for solid-liquid separation. Centrifuge the separated liquid to remove most particles. Add 90 parts by weight of butylene glycol and 125 parts by weight of ultrapure water to the centrifuged liquid. Stir thoroughly and filter through a 0.22 μm microporous membrane to obtain an extract that improves facial redness.

[0044] Example 3

[0045] The difference between Example 3 and Example 1 is that the ratio and extraction conditions of the Chinese medicine composition are adjusted.

[0046] 25 parts by weight of Leonurus japonicus and 5 parts by weight of Corydalis serrulata were weighed and added to softened water (6 times the total weight of the herbs). The mixture was then immersed in water for extraction at room temperature for 0.5 hours. After extraction, the mixture was filtered through a 100-mesh filter for solid-liquid separation. The separated liquid was centrifuged to remove most of the particles. 65 parts by weight of butylene glycol and 105 parts by weight of ultrapure water were added to the centrifuged liquid. The mixture was stirred evenly and filtered through a 0.22 μm microporous membrane to obtain an extract for improving facial redness.

[0047] Comparative Example 1

[0048] The difference between Comparative Example 1 and Example 1 is that the dentate petal Corydalis yanhusuo is removed from the traditional Chinese medicine composition.

[0049] Weigh 40 parts by weight of Leonurus japonicus and add it to 8 times the weight of the herb in softened water. Soak and extract at room temperature for 1 hour. After extraction, filter through a 100-mesh filter for solid-liquid separation. Centrifuge the separated liquid to remove most particles. Add 80 parts by weight of butylene glycol and 116 parts by weight of ultrapure water to the centrifuged liquid. Stir thoroughly and filter through a 0.22 μm microporous membrane to obtain an extract that improves facial redness.

[0050] Comparative Example 2

[0051] The difference between Comparative Example 2 and Example 1 is that Leonurus japonicus is removed from the traditional Chinese medicine composition.

[0052] Weigh 40 parts by weight of Corydalis dentata and add it to 8 times the weight of the herb in softened water. Soak and extract at room temperature for 1 hour. After extraction, filter through a 100-mesh filter for solid-liquid separation. Centrifuge the separated liquid to remove most particles. Add 80 parts by weight of butylene glycol and 116 parts by weight of ultrapure water to the centrifuged liquid. Stir thoroughly and filter through a 0.22 μm microporous membrane to obtain an extract that improves facial redness.

[0053] Comparative Example 3

[0054] The difference between Comparative Example 3 and Example 1 is that the Corydalis dentata in the traditional Chinese medicine composition is replaced with Tremella fuciformis having similar efficacy.

[0055] Weigh 32 parts by weight of Leonurus japonicus and 8 parts by weight of Tremella fuciformis, add 8 times the weight of softened water, and soak for 1 hour at room temperature. After extraction, filter through a 100-mesh filter for solid-liquid separation. Centrifuge the separated liquid to remove most particles. Add 80 parts by weight of butylene glycol and 116 parts by weight of ultrapure water to the centrifuged liquid. Stir thoroughly, then filter through a 0.22 μm microporous membrane to obtain an extract that improves facial redness.

[0056] Test Example 1

[0057] 1. Subjects

[0058] 30 female subjects with facial red blood vessels were selected.

[0059] 2. Inclusion criteria

[0060] (1) Facial red blood vessels were in a punctate, filamentous or reticular distribution;

[0061] (2) Capillary diameter ≥ 0.1 mm;

[0062] (3) Dilated capillaries ≥ 5 per cm 2 ;

[0063] (4) Skin lesion area ≥ 3 cm x 3 cm;

[0064] (5) Diffuse flushing of the local skin.

[0065] Any one or several of the above criteria can be included.

[0066] 3. Exclusion criteria

[0067] (1) Lactating and pregnant or planning to be pregnant women;

[0068] (2) Using photosensitive drugs;

[0069] (3) Receiving other facial treatments at the same time;

[0070] (4) Drug allergy;

[0071] (5) Participating in other clinical trials within the past month.

[0072] 4. Treatment method

[0073] The extracts described in the examples and comparative examples were made into face masks, and the face mask formula is shown in Table 1. The subjects were divided into 6 groups using a stratified random grouping method, with 5 subjects in each group. The subjects in each group applied the face masks made from Examples 1-3 and Comparative Examples 1-3 before going to bed on Monday, Wednesday and Friday every week, for a continuous period of three weeks. On Sunday every week, the subjects were photographed by a VISIA skin detector, and the skin erythema was measured. The lower the erythema value, the better the effect of improving facial red blood vessels.

[0074]

[0075] 5. Statistical processing

[0076] Measurement data was expressed as , and SPSS 20.0 software was used for statistical analysis. Variance analysis was used to compare the erythema index between the two groups, and P≤0.05 indicated that the difference was statistically significant.

[0077] 6. Results

[0078] The results in Table 2 show that the extracts provided in Examples 1-3 effectively reduced the facial erythema index, with statistically significant differences between pre-treatment and post-treatment. Comparative Examples 1 and 3 also effectively reduced the erythema index, but the effects were not as strong as those of the Examples. The extract provided in Comparative Example 2 did not reduce the erythema index, with no statistical significance.

[0079]

[0080] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be considered as equivalent replacement methods and are included in the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for improving facial redness, characterized in that The invention is composed of the following ingredients in parts by mass: 25-40 parts of Leonurus japonicus and 5-15 parts of Corydalis yanhusuo.

2. A method for preparing an extract for improving facial redness, characterized in that The method comprises the following steps: extracting the traditional Chinese medicine composition according to claim 1 with water to obtain an extract for improving facial red blood streaks.

3. The method for preparing the extract for improving facial redness according to claim 2, characterized in that The steps include: (1) extracting the Chinese herbal composition for improving facial redness according to claim 1 with water, separating the solid and the liquid, and taking the liquid; (2) further clarifying the liquid obtained in step (1) to obtain an extract; (3) Add polyol and water to the extract and mix well to obtain an extract for improving facial redness.

4. The method for preparing the extract for improving facial redness according to claim 3, wherein: The water described in step (1) is softened water; The amount of water used in step (1) is 6 to 10 times the mass of the Chinese medicine composition; The solid-liquid separation method in step (1) is filtration; The clarification method in step (2) is centrifugation; The polyol described in step (3) is butanediol; The amount of the polyol in step (3) is calculated based on the polyol being 1.5 to 2.5 times the mass of the traditional Chinese medicine composition; The water described in step (3) is ultrapure water; The amount of water used in step (3) is calculated based on the mass of water being 2 to 4 times the mass of the traditional Chinese medicine composition.

5. An extract for improving facial redness, characterized by: The method is obtained by the preparation method according to any one of claims 2 to 4.

6. Use of the traditional Chinese medicine composition for improving facial redness according to claim 1 or the extract for improving facial redness according to claim 5 in the preparation of a skin care product for improving facial redness.

7. A skin care product for improving facial redness, characterized by: Contains the extract for improving facial redness as claimed in claim 5.

8. The skin care product for improving facial redness according to claim 7, characterized in that The invention contains the following ingredients in percentage by mass: EDTA-2Na 0.05%, silicone wax DC2501 0.5%, cinnamone 0.3%, hydroxyethyl urea 4%, sarin resin PC2000 0.02%, the extract for improving facial redness according to claim 5 2%, hydroxyethyl cellulose 0.3%, sodium hyaluronate 0.03%, glycerin 5%, essence 0.02%, HPS 0.1%, 1,3-propylene glycol 1%, and PE9010 0.15%.

9. The method for preparing the skin care product for improving facial redness according to claim 8, characterized in that The steps include: 1) Mix EDTA-2Na, silicone wax DC2501, cinnamone, hydroxyethyl urea, sarin resin PC2000, the extract for improving facial redness according to claim 5, and water, and heat to 75-80° C. while stirring to obtain phase A; 2) Combine hydroxyethyl cellulose, sodium hyaluronate, glycerin, and flavor, stirring until there are no fine particles to obtain Phase B. Add Phase B to Phase A, mix well, and keep warm at 75-80°C until completely dissolved. 3) Mix HPS, 1,3-propylene glycol, and water to obtain phase C; 4) The product finally obtained in step 2) is cooled to 40-42° C., phase C and PE9010 are added, stirred evenly, and filtered to obtain a skin care product for improving facial redness.

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