Traditional Chinese medicine for treating functional dyspepsia and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine for treating functional dyspepsia. The traditional Chinese medicine comprises a first component and a second component, the first component comprises 14-16 parts by weight of codonopsis pilosula, 9-11 parts by weight of bighead atractylodes rhizome, 13-16 parts by weight of poria cocos, 9-11 parts by weight of honey-fried licorice root, 13-16 parts by weight of fructus alpiniae oxyphyllae, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of bamboo shavings, 8-11 parts by weight of rhizoma pinellinae praeparata, 8-11 parts by weight of radix curcumae and 8-11 parts by weight of rhizoma cimicifugae. The invention also discloses a preparation method of the traditional Chinese medicine for treating functional dyspepsia. Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention can be used for remarkably improving symptoms such as poor appetite, abdominal distension after eating, irregular stool, fatigue and weakness, lusterless complexion and the like caused by weakness of the spleen and the stomach.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine for treating functional dyspepsia and a preparation method thereof. Background Art

[0002] Spleen and stomach weakness is one of the common diseases in traditional Chinese medicine theory. Its clinical manifestations mainly include loss of appetite, abdominal distension after eating, irregular bowel movements, fatigue, and sallow complexion. These symptoms are usually related to functional dyspepsia and affect the daily quality of life of patients. At present, Western medicine treatment methods mostly use antacids and gastrointestinal motility drugs, but these drugs can only temporarily relieve symptoms, it is difficult to fundamentally solve the problem, and there may be side effects.

[0003] Traditional Chinese medicine believes that the spleen and stomach are the foundation of the acquired constitution and the source of qi and blood. Weak spleen and stomach lead to abnormal transportation and transformation, resulting in the above-mentioned series of symptoms. Therefore, strengthening the spleen and replenishing qi, and harmonizing the stomach and digesting food have become important principles for treating such diseases. Although some existing Chinese medicine prescriptions can play a certain therapeutic role, they still have shortcomings in terms of efficacy, safety and convenience of taking.

[0004] In view of this, a traditional Chinese medicine for treating functional dyspepsia and a preparation method thereof are proposed. Summary of the invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine for treating functional dyspepsia and a preparation method thereof. The present invention can significantly improve the symptoms of loss of appetite, abdominal distension after eating, irregular bowel movements, fatigue, and sallow complexion caused by spleen and stomach weakness.

[0006] The above technical objectives of the present invention are achieved through the following technical solutions:

[0007] A traditional Chinese medicine for treating functional dyspepsia comprises a first component, wherein the first component comprises 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Pinellia ternata, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia.

[0008] In a preferred embodiment, the first component includes 15 parts by weight of Codonopsis pilosula, 10 parts by weight of Atractylodes macrocephala, 15 parts by weight of Poria cocos, 10 parts by weight of Radix Glycyrrhizae Preparata, 15 parts by weight of Alpinia oxyphylla, 15 parts by weight of raw ochre, 15 parts by weight of raw malt, 15 parts by weight of raw hawthorn, 15 parts by weight of Rhizoma Anemarrhenae, 10 parts by weight of Pinellia ternata, 10 parts by weight of Curcuma aromatica and 10 parts by weight of Cimicifuga heracleifolia.

[0009] In a preferred embodiment, the second component is also included, which includes 3-6 weight parts of Platycladus orientalis, 4-6 weight parts of Red Peony Root, 2-4 weight parts of Ophiopogon japonicus, 5-8 weight parts of Citrus aurantium, 3-5 weight parts of Platycodon grandiflorum, 5-9 weight parts of Cassia twig, 4-8 weight parts of Aucklandia root, 3-5 weight parts of Licorice, 3-5 weight parts of Aquilaria wood and 4-6 weight parts of Ziziphus jujuba seed.

[0010] In a preferred embodiment, the second component includes 4 parts by weight of Platycladus orientalis, 5 parts by weight of Red Peony Root, 3 parts by weight of Ophiopogon japonicus, 7 parts by weight of Fructus Aurantii Immaturus, 4 parts by weight of Platycodon grandiflorum, 7 parts by weight of Cinnamomum cassia twig, 6 parts by weight of Aucklandia lappa, 4 parts by weight of Licorice, 4 parts by weight of Aquilaria sinensis and 5 parts by weight of Semen Ziziphi Spinosae.

[0011] In a preferred embodiment, the first component and the second component are made into particles, wherein the first component is coated on the outside of the second component.

[0012] A method for preparing a traditional Chinese medicine for treating functional dyspepsia comprises the following steps:

[0013] S1, take the first component, the first component includes 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Pinellia ternata, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia;

[0014] S2, sending the first component into an extractor, adding 15 times the total weight of the medicinal materials into the first component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a first extract;

[0015] S3, granulating the first extract.

[0016] In a preferred embodiment, the steps include:

[0017] S1, take the first component and the second component, the first component includes 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Rhizoma Pinelliae, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia; the second component includes 3-6 parts by weight of Semen Platycladi, 4-6 parts by weight of Paeonia lactiflora, 2-4 parts by weight of Radix Ophiopogonis, 5-8 parts by weight of Fructus Aurantii Immaturus, 3-5 parts by weight of Platycodon grandiflorum, 5-9 parts by weight of Cinnamomum cassia, 4-8 parts by weight of Aucklandia lappa, 3-5 parts by weight of Radix Glycyrrhizae, 3-5 parts by weight of Aquilaria sinensis, and 4-6 parts by weight of Semen Ziziphi Spinosae;

[0018] S2, respectively sending the first component and the second component into the extractor, adding water 15 times the total weight of the medicinal materials to the first component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a first extract; adding water 13 times the total weight of the medicinal materials to the second component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a second extract;

[0019] S3, granulating the first extract and the second extract, and making the first extract cover the outside of the second extract.

[0020] Compared with the prior art, the present invention can effectively improve the symptoms of loss of appetite, abdominal distension after eating, irregular bowel movements, fatigue, and sallow complexion caused by weak spleen and stomach. At the same time, a second component is added to achieve mood regulation. Through the repair of the body and the improvement of mood, the two are combined to achieve a thorough cure for the symptoms of indigestion. In addition, during preparation, the first component is coated on the outside of the second component. Through such a setting, it is effectively ensured that the first component can act on the stomach, so that the first component plays a core role in treating the symptoms of indigestion and ensures the dosage. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is an experimental technology route.

[0022] Figure 2 It is the experimental weight result.

[0023] Figure 3 It is the result of the experimental food intake.

[0024] Figure 4 It is the result of the experimental water intake.

[0025] Figure 5 It is the result of experimental serum index.

[0026] Figures 6 to 9 It is the experimental metabolite result.

[0027] Figures 10 to 13 The experiment is a metabolic pathway result.

[0028] Fig.14 It is the result at the level of experimental bacterial flora.

[0029] Figures 15 to 18 It is the result of the experimental level.

[0030] Figures 19 to 25 It is a bar chart of community functions.

[0031] Fig.26 The present invention is a flow chart of a method for preparing a traditional Chinese medicine for treating functional dyspepsia. DETAILED DESCRIPTION

[0032] The present invention is further described in detail below in conjunction with the accompanying drawings.

[0033] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

[0034] Embodiment 1:

[0035] A traditional Chinese medicine for treating functional dyspepsia comprises a first component, wherein the first component comprises 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Pinellia ternata, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia.

[0036] Specifically, take the first component: 15 weight parts of Codonopsis pilosula, 10 weight parts of Atractylodes macrocephala, 15 weight parts of Poria cocos, 10 weight parts of Radix Glycyrrhizae, 15 weight parts of Alpinia oxyphylla, 15 weight parts of raw ochre, 15 weight parts of raw malt, 15 weight parts of raw hawthorn, 15 weight parts of Rhizoma Anemarrhenae, 10 weight parts of Pinellia ternata, 10 weight parts of Curcuma aromatica and 10 weight parts of Cimicifuga heracleifolia.

[0037] Furthermore, it also includes a second component, which includes 3-6 weight parts of Platycladus orientalis, 4-6 weight parts of red peony root, 2-4 weight parts of Ophiopogon japonicus, 5-8 weight parts of Citrus aurantium, 3-5 weight parts of Platycodon grandiflorum, 5-9 weight parts of cinnamon twig, 4-8 weight parts of costus root, 3-5 weight parts of liquorice, 3-5 weight parts of agarwood and 4-6 weight parts of Ziziphus jujuba seed.

[0038] Specifically, the second component includes 4 parts by weight of Platycladus orientalis, 5 parts by weight of Red Peony Root, 3 parts by weight of Ophiopogon japonicus, 7 parts by weight of Citrus aurantium, 4 parts by weight of Platycodon grandiflorum, 7 parts by weight of Cinnamon Twig, 6 parts by weight of Aucklandia rosea, 4 parts by weight of Licorice, 4 parts by weight of Aquilaria wood and 5 parts by weight of Ziziphus jujuba seed.

[0039] In a preferred embodiment, the first component and the second component are made into particles, wherein the first component is coated on the outside of the second component.

[0040] The present invention can effectively improve the symptoms of loss of appetite, abdominal distension after eating, irregular bowel movements, fatigue, and sallow complexion caused by weak spleen and stomach. At the same time, a second component is added to achieve mood regulation. Through the repair of the body and the improvement of mood, the two are combined to achieve a thorough cure of the symptoms of indigestion. In addition, during preparation, the first component is coated on the outside of the second component. Through such a setting, it is effectively ensured that the first component can act on the stomach, so that the first component plays a core role in treating the symptoms of indigestion and ensures the dosage.

[0041] The experimental process and experimental data of the relevant effects are as follows:

[0042] 1. Experimental Animals

[0043] 40 clean-grade SD rats, half male and half female, were purchased from Hunan Slake Jingda Experimental Animal Co., Ltd. License number: SYXK (Xiang 2019-0004). Eight rats were kept in a cage in the animal room of the First Affiliated Hospital of Guangxi University of Chinese Medicine, with a 12-hour circadian rhythm and a room temperature of 22.0±2℃. They were fed with ordinary feed and had free access to water. The feeding and experimental processes of the animals involved in the experiment were in compliance with the relevant provisions of the Guidelines for the Management and Protection of Laboratory Animals of Guangxi University of Chinese Medicine and the Guiding Opinions on the Kindness of Experimental Animals issued by the Ministry of Science and Technology of the People's Republic of China in 2006.

[0044] 2. Reagents and Instruments

[0045] Iodoacetamide was purchased from Sigma; sucrose was purchased from Biodyne; cholecystokinin test kit and somatotropin test kit were purchased from Nanjing Jiancheng Bioengineering Institute; LC-MS grade acetonitrile and methanol were purchased from Merck; formic acid, ammonium formate and ammonia water were purchased from Aladdin; Tiangen magnetic bead extraction kit was purchased from Qiagen; CTAB extraction kit was purchased from Nobleryder; library construction kit (Next Ultra DNA Library Prep Kit) was purchased from NEB, and sequencing kit was purchased from Illumina.

[0046] Ordinary desktop centrifuge (purchased from Shanghai Luxiangyi Centrifuge Instrument Co., Ltd.); ELISA reader (purchased from Shanghai Meigu Molecular); ultra-high performance liquid chromatography (purchased from Shanghai SCIEX Aibocaisi Analytical Instrument Trading Co., Ltd.); tandem mass spectrometer (purchased from Shanghai SCIEX Aibocaisi Analytical Instrument Trading Co., Ltd.); electronic balance (purchased from Shanghai Precision Instrument Co., Ltd.); quadrupole electrostatic field orbital trap mass spectrometer (purchased from Thermo Fisher Scientific, USA); sequencer Illumina Novasek6000 (purchased from Illumina, USA).

[0047] 3. Modeling and grouping

[0048] Grouping and modeling: After all rats were adaptively fed for 3 days, 40 rats were randomly divided into a blank group (K group), a model group (M group), a low-dose group (ZL group), a medium-dose group (ZM group), and a high-dose group (ZH group), with 8 rats in each group, half male and half female. The blank group was given 2% sucrose solution by gavage; the rat model of spleen deficiency type functional dyspepsia was established by gavage of iodoacetamide combined with the modified small platform method, and the model group and the low, medium and high dose groups were all given 0.1% sucrose iodoacetamide solution (0.2 ml / rat). Both groups were given the modified small platform method, and the water in the small platform standing water tank was filled to 2.0 cm below the small platform table. Rats can move freely on the small platform. Once they fall asleep, their muscles relax and they will fall into the water, making it impossible for the rats to rest and causing fatigue. The small platform standing was performed from 18:00 to 8:00 every day, lasting 14 hours a day, for 14 consecutive days, and the modeling was completed.

[0049] Signs of successful rat modeling: The rats' body weight progressively decreases; their activity level changes from frequent spontaneous fighting in the cage to curling up in piles, not moving even when the cage is knocked, and slow to react to being caught; their emotions change from being irritable and irritable at the slightest sound to having no special reaction to continuous noise stimulation or feeding, and their emotions are abnormally low; their fur changes from white and smooth to messy, floppy, and yellow; their feces change from dark brown, dry, hard, odorless, and long cylindrical to brown-yellow, moist, soft, slightly smelly, and short cylindrical, and finally to yellow-green loose stools, with undigested granular feed visible.

[0050] 4. Dosage regimen

[0051] Drug administration began 24 hours after successful modeling. The blank group and the model group were gavaged with normal saline, and the others were gavaged with low, medium, and high doses. The five groups were gavaged once a day for 2 weeks.

[0052] A. Blank group: 8 mice, given an equal amount of distilled water by gavage, once a day, for 2 consecutive weeks;

[0053] B. Model group: 8 rats, given an equal amount of distilled water by gavage, once a day, for 2 consecutive weeks;

[0054] C. Low-dose group: 8 mice were given low-dose oral gavage once a day for 2 consecutive weeks;

[0055] D. Medium-dose group: 8 mice were given a medium-dose oral gavage, once a day, for 2 consecutive weeks;

[0056] E. High-dose group: 8 mice were given high-dose oral administration once a day for 2 consecutive weeks.

[0057] The dosage of the drug is converted according to the "Dose Conversion Coefficient Table for Animals and Humans per Kilogram Body Weight": The conversion coefficient between humans and rats is 6.25, calculated based on an adult of 60 kg, and the total dose of granules is 155g. The conversion formula for rat dosage: Normal dosage for rats = human dosage / day ÷ human weight × 6.25. The normal dosage for rats is taken as the medium dose. The low dose, medium dose, and high dose are converted according to 1:2:4, that is, the low, medium, and high dose groups are: 8.07g·kg-1·d-1, 16.15g·kg-1·d-1, and 32.29g·kg-1·d-1, respectively.

[0058] 5. Get materials

[0059] Three days before the end of the rat experiment, the rat feces were collected for the later metagenomic flora analysis of the feces. The feces were collected by the tail reflex method, and the specific operation was as follows: gently grab the rat, fix the head and back of the rat, lift the rat's tail to expose the anus, and touch the vicinity of its anus with a sterile cotton swab to stimulate defecation. Fecal particles were collected with sterile tweezers, stored in a 5ml cryotube, stored in dry ice or liquid nitrogen, and transferred to -80℃ as soon as possible for storage. After taking the fecal sample, the anus was disinfected with alcohol and the rat was returned to its original cage. After the last dose, fasting for 24h to promote intestinal emptying of the rat, the animal was killed by cervical dislocation, and blood was collected by abdominal aorta blood collection. Then the abdominal cavity was opened to find the stomach and duodenal tissues, cleaned with saline, and placed in a -80℃ refrigerator for standby use.

[0060] The experimental results are as follows Figures 2 to 25 .

[0061] Embodiment 2:

[0062] like Fig.26 As shown, a method for preparing a traditional Chinese medicine for treating functional dyspepsia comprises the steps of:

[0063] S1, take the first component, the first component includes 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Pinellia ternata, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia;

[0064] S2, sending the first component into an extractor, adding 15 times the total weight of the medicinal materials into the first component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a first extract;

[0065] S3, granulating the first extract to obtain granules.

[0066] The Chinese medicine prepared by the Chinese medicine preparation method for treating functional dyspepsia in this embodiment can effectively improve the symptoms such as loss of appetite, abdominal distension after eating, irregular bowel movements, fatigue, and sallow complexion caused by weak spleen and stomach.

[0067] Further, the steps include:

[0068] S1, take the first component and the second component, the first component includes 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Rhizoma Pinelliae, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia; the second component includes 3-6 parts by weight of Semen Platycladi, 4-6 parts by weight of Paeonia lactiflora, 2-4 parts by weight of Radix Ophiopogonis, 5-8 parts by weight of Fructus Aurantii Immaturus, 3-5 parts by weight of Platycodon grandiflorum, 5-9 parts by weight of Cinnamomum cassia, 4-8 parts by weight of Aucklandia lappa, 3-5 parts by weight of Radix Glycyrrhizae, 3-5 parts by weight of Aquilaria sinensis, and 4-6 parts by weight of Semen Ziziphi Spinosae;

[0069] S2, respectively sending the first component and the second component into the extractor, adding water 15 times the total weight of the medicinal materials to the first component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a first extract; adding water 13 times the total weight of the medicinal materials to the second component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a second extract;

[0070] S3, granulating the first extract and the second extract, and making the first extract cover the outside of the second extract.

[0071] The second component is used to achieve mood regulation and is a tranquilizer. By combining the repair of the body and the improvement of mood, the two can achieve a complete cure for the symptoms of indigestion. In addition, during preparation, the first component is coated on the outside of the second component. Through such a setting, it is effectively ensured that the first component can act on the stomach, so that the first component plays a core role in treating the symptoms of indigestion and ensures the dosage.

[0072] During the preparation process, the second extract is first granulated to form a core body, and preheated to 65-75°C, and then the first extract is spread on a flat plate, so that the core body rolls on the first extract. While rolling, the flat plate vibrates to form coated particles, that is, the first group is coated on the core body, and then the coated particles are sent to a microwave heating furnace and strongly heated for 10-30s, and then the coated particles are sent to a drying box for drying to finally obtain finished particles.

[0073] The advantage of doing this is that, on the one hand, by preheating, the temperature of the core body is kept high, which is conducive to its drying. In the subsequent drying process, the drying process of the particles can be made more uniform. On the other hand, by preheating the core body, the temperature of the core body is made higher than the temperature of the first extract coated on the outside. When heated violently by microwaves, the core body first reaches the intense evaporation temperature, and a large amount of water in the core body is evaporated and passes through the first extract coated on the outer layer, so that pores appear on the first extract. The generation of pores, on the one hand, helps the penetration of digestive juices, speeds up digestion, and allows the drug to be quickly digested and absorbed. On the other hand, it also allows the digestive juice to contact the core body in small amounts, thereby ensuring that the function of the first component is prioritized while allowing the second component to function simultaneously.

[0074] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that the process, method, article or terminal device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or terminal device. In the absence of further restrictions, the elements defined by the sentence "include..." or "comprise..." do not exclude the existence of other elements in the process, method, article or terminal device including the elements. In addition, in this article, "greater than", "less than", "exceed" and the like are understood to exclude the number itself; "above", "below", "within" and the like are understood to include the number itself.

[0075] The above description of the embodiments is to facilitate the understanding and use of the present invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to the embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments. Improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the protection scope of the present invention.

Claims

1. A Chinese medicine for treating functional dyspepsia, characterized in that: The invention comprises a first component, which comprises 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Pinellia ternata, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia.

2. A Chinese medicine for treating functional dyspepsia according to claim 1, characterized in that: The first component includes 15 parts by weight of Codonopsis pilosula, 10 parts by weight of Atractylodes macrocephala, 15 parts by weight of Poria cocos, 10 parts by weight of Radix Glycyrrhizae Preparata, 15 parts by weight of Alpinia oxyphylla, 15 parts by weight of raw ochre, 15 parts by weight of raw malt, 15 parts by weight of raw hawthorn, 15 parts by weight of Rhizoma Anemarrhenae, 10 parts by weight of Pinellia ternata, 10 parts by weight of Curcuma aromatica and 10 parts by weight of Cimicifuga heracleifolia.

3. A Chinese medicine for treating functional dyspepsia according to claim 1, characterized in that: It also includes a second component, which includes 3-6 weight parts of Platycladus orientalis, 4-6 weight parts of red peony root, 2-4 weight parts of Ophiopogon japonicus, 5-8 weight parts of Citrus aurantium, 3-5 weight parts of Platycodon grandiflorum, 5-9 weight parts of cinnamon twig, 4-8 weight parts of costus root, 3-5 weight parts of liquorice, 3-5 weight parts of agarwood and 4-6 weight parts of Ziziphus jujuba seed.

4. A Chinese medicine for treating functional dyspepsia according to claim 1, characterized in that: The second component includes 4 parts by weight of Platycladus orientalis, 5 parts by weight of Red Peony Root, 3 parts by weight of Ophiopogon japonicus, 7 parts by weight of Fructus Aurantii Immaturus, 4 parts by weight of Platycodon grandiflorum, 7 parts by weight of Cinnamomum cassia twig, 6 parts by weight of Aucklandia lappa, 4 parts by weight of Licorice, 4 parts by weight of Aquilaria sinensis and 5 parts by weight of Semen Ziziphi Spinosae.

5. A Chinese medicine for treating functional dyspepsia according to claim 3 or 4, characterized in that: The first component and the second component are made into particles, wherein the first component is coated on the outside of the second component.

6. A method for preparing a traditional Chinese medicine for treating functional dyspepsia, characterized in that: Includes steps: S1, take the first component, the first component includes 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Pinellia ternata, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia; S2, sending the first component into an extractor, adding 15 times the total weight of the medicinal materials into the first component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a first extract; S3, granulating the first extract.

7. A method for preparing a traditional Chinese medicine for treating functional dyspepsia according to claim 6, characterized in that: Includes steps: S1, take the first component and the second component, the first component includes 14-16 parts by weight of Codonopsis pilosula, 9-11 parts by weight of Atractylodes macrocephala, 13-16 parts by weight of Poria cocos, 9-11 parts by weight of Radix Glycyrrhizae Preparata, 13-16 parts by weight of Alpinia oxyphylla, 13-16 parts by weight of raw ochre, 13-17 parts by weight of raw malt, 14-16 parts by weight of raw hawthorn, 14-16 parts by weight of Rhizoma Anemarrhenae, 8-11 parts by weight of Rhizoma Pinelliae, 8-11 parts by weight of Curcuma aromatica, and 8-11 parts by weight of Cimicifuga heracleifolia; the second component includes 3-6 parts by weight of Semen Platycladi, 4-6 parts by weight of Paeonia lactiflora, 2-4 parts by weight of Radix Ophiopogonis, 5-8 parts by weight of Fructus Aurantii Immaturus, 3-5 parts by weight of Platycodon grandiflorum, 5-9 parts by weight of Cinnamomum cassia, 4-8 parts by weight of Aucklandia lappa, 3-5 parts by weight of Radix Glycyrrhizae, 3-5 parts by weight of Aquilaria sinensis, and 4-6 parts by weight of Semen Ziziphi Spinosae; S2, respectively sending the first component and the second component into the extractor, adding water 15 times the total weight of the medicinal materials to the first component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a first extract; adding water 13 times the total weight of the medicinal materials to the second component, extracting for 1-1.5 hours, filtering the extract with a 200-mesh standard sieve, and concentrating the extract to 1.1 g / ml to obtain a second extract; S3, granulating the first extract and the second extract, and making the first extract cover the outside of the second extract.

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