Tumor electric field treatment system and temperature detection method, signal control method

Abstract

The application provides a tumor electric field treatment system and a temperature detection method and a signal control method. The tumor electric field treatment system comprises at least one pair of electrode sheets, an electric field generator and an adapter. The electrode sheet comprises a plurality of electrode units and a flexible circuit board. The flexible circuit board is provided with a plurality of grounding lines and a plurality of dual-purpose signal lines. Each grounding line is connected to the electrode units in the same row. Each dual-purpose signal line is electrically connected to the electrode units in the same column and transmits an alternating current signal in a first mode and a temperature detection signal in a second mode. The adapter comprises a plurality of groups of multi-circuit lines. Each group of multi-circuit lines is electrically connected to the corresponding dual-purpose signal line and the corresponding grounding line of the electrode sheet to transmit an alternating current signal or a direct current signal for temperature detection. Part of each group of multi-circuit lines is turned on when transmitting an alternating current signal, and part of each group of multi-circuit lines is turned on when transmitting a direct current signal. The corresponding electrode sheet can be matched to avoid idle circuit lines.

Description

Technical Field

[0001] The present application relates to Tumor Treating Fields (TTF) technology, and in particular to a tumor treating field system, a temperature detection method, and a signal control method. Background Art

[0002] Tumor electric field therapy is a method that uses low-intensity, medium- and high-frequency alternating electric fields to prevent the formation of spindle microtubules during mitosis in certain tumor cells, thereby inhibiting the separation of intracellular organelles during cell division and inducing cell apoptosis during mitosis, thereby achieving the purpose of treating tumors.

[0003] Compared with traditional cancer treatments, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as geometric shape and high-frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting directional forces on polar particles (such as macromolecules and organelles) in cells. These processes may lead to physical damage to the cell membrane and cell apoptosis. At the end of cell mitosis, the structural morphology of the cleavage furrow will lead to uneven distribution of the electric field around it. At the same time, under the influence of TTF, the electric field intensity at the cleavage furrow is significantly enhanced, and the charged substances in the cell move toward the cleavage furrow, which interferes with or even destroys the formation of the cell structure, and ultimately leads to cell division failure and apoptosis.

[0004] In existing tumor electric field therapy systems, an electric field generator is used to transmit the alternating current signal for tumor electric field therapy to the electrode patch, which then applies an alternating electric field to the patient's tumor site through the electrode patch for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat will accumulate at the electrode patch application site, and the temperature of the electrode patch application site will also increase accordingly. Therefore, it is necessary to monitor the temperature of the electrode patch application site in real time. When the monitored temperature rises to a certain preset value, it is necessary to promptly adjust the electric field strength applied to the patient's tumor site to avoid excessive temperature at the electrode patch application site, which may cause burns to the patient's skin.

[0005] A tumor electric field therapy system includes at least one pair of electrode sheets, each of which contains multiple electrode units. Even when the same alternating current signal is applied to each electrode unit, the heat generated by each electrode unit will vary depending on its location. This means that the temperature of each electrode unit across the entire electrode sheet will not be completely consistent. This can result in some electrode units exceeding a preset temperature while other electrode units remain within normal limits. To prevent excessively high patient surface temperatures during prolonged tumor electric field therapy and to ensure that an alternating electric field can be applied to the patient's tumor site for a long period of time, it is necessary to individually control overheated electrode units. However, with existing electrode sheets, individually controlling the electrode units requires providing a conductive trace for each electrode unit within the electrode sheet's substrate. This increases the number of conductive traces within the electrode sheet's substrate, making it difficult to bend the electrode sheet. Furthermore, the cables electrically connected to the electrode sheet will be thicker, increasing the overall weight of the electrode sheet and hindering its application.

[0006] Therefore, it is necessary to provide an electrode sheet, a tumor electric field therapy system, a temperature detection method, and a signal application method that use fewer conductive traces to perform partitioned control on multiple electrode units. Summary of the Invention

[0007] The first object of the present application is to provide a tumor electric field therapy system to solve or eliminate the problems in the related art.

[0008] The second object of the present application is to provide a method for detecting the temperature of an electrode.

[0009] The third object of the present application is to provide a signal control method for tumor electric field therapy.

[0010] To achieve the above-mentioned purpose, the present application provides the following technical solutions: a tumor electric field therapy system, comprising: at least one pair of electrode sheets, the electrode sheets comprising a plurality of electrode units and a flexible circuit board, the plurality of electrode units being divided into a plurality of row groups and a plurality of column groups on the circuit; the flexible circuit board being configured for the plurality of electrode units to be arranged thereon at intervals, the flexible circuit board being embedded with a plurality of conductive traces, the plurality of conductive traces comprising: a plurality of grounding lines and a plurality of dual-purpose signal lines, the plurality of grounding lines being connected to the plurality of row groups in a one-to-one correspondence, each of the grounding lines being configured to short-circuit each electrode unit in the corresponding row group to ground, the plurality of dual-purpose signal lines being connected to the plurality of column groups in a one-to-one correspondence, each of the dual-purpose signal lines being configured to transmit an alternating current signal to each electrode unit in the corresponding column group in a first mode, and to transmit an alternating current signal to each electrode unit in the corresponding column group in a second mode. A direct current signal is transmitted to perform temperature detection and transmit the temperature detection signal detected by each electrode unit; an electric field generator is configured to transmit an alternating current signal to multiple electrode units of the electrode sheet via the dual-purpose signal line of the electrode sheet; and an adapter is connected between the electrode sheet and the electric field generator, has multiple groups of multi-way circuit lines and is configured to transmit the alternating current signal generated by the electric field generator to the dual-purpose signal line of the corresponding electrode sheet through the corresponding circuit lines in the corresponding group of multi-way circuit lines, and is also configured to receive the temperature detection signal output by the dual-purpose signal line of the electrode sheet through the corresponding circuit lines in the corresponding group of multi-way circuit lines, part of the circuit lines in each group of multi-way circuit lines are turned on when electrically connected to the corresponding electrode sheet to transmit the alternating current signal, and the remaining part of the circuit lines in each group of multi-way circuit lines are turned on when electrically connected to the corresponding electrode sheet to transmit the direct current signal for temperature detection.

[0011] The tumor electric field therapy system of this application features multiple dual-purpose signal lines on the flexible circuit board of the electrode sheet. Each dual-purpose signal line connects multiple electrode units located in the same column of the circuit, capable of transmitting both AC and DC signals to collect temperature detection signals from each electrode unit. This eliminates the need for separate conductive traces dedicated solely to AC signal transmission, reducing the number of wires required to connect the electrode sheet and the adapter. Furthermore, the adapter's multiple circuit lines are partially conductive when transmitting AC signals and partially conductive when transmitting DC signals, matching the corresponding electrode sheet, eliminating unused circuit lines and facilitating program control.

[0012] Furthermore, the adapter also includes multiple groups of bidirectional switching switches electrically connected one-to-one with multiple groups of circuit lines, each group of bidirectional switching switches is electrically connected one-to-one with the multi-channel dual-purpose signal lines corresponding to the electrode pieces and includes multiple bidirectional switching switches, and the multiple bidirectional switching switches in each group of bidirectional switching switches respectively control the multi-channel dual-purpose signal lines of the electrode pieces electrically connected thereto to switch between transmitting AC signals and transmitting DC signals.

[0013] Furthermore, the adapter includes multiple groups of grounding switches electrically connected one by one to multiple groups of circuit lines, and each group of grounding switches is also electrically connected one by one to the multiple grounding lines corresponding to the electrode sheets and includes multiple grounding switches that respectively control the conduction and disconnection of the multiple grounding lines corresponding to the electrode sheets electrically connected thereto.

[0014] Furthermore, the number of the bidirectional switches in each group is equal to the number of the dual-purpose signal lines corresponding to the electrode sheets, and the number of the grounding switches in each group is equal to the number of the grounding lines corresponding to the electrode sheets.

[0015] Furthermore, each group of multi-channel circuit lines of the adapter also includes: an AC signal line, which is configured to transmit alternating current signals to each of the electrode units in the corresponding column group of the electrode sheet through the multiple dual-purpose signal lines of the corresponding electrode sheet.

[0016] Furthermore, the adapter also includes: multiple groups of analog-to-digital converters, each group of analog-to-digital converters is electrically connected to the multiplexed signal line of the corresponding electrode sheet through the corresponding group of corresponding circuit lines, and is configured to receive the temperature detection signal transmitted by the multiplexed signal line of the corresponding electrode sheet through the corresponding group of corresponding circuit lines and convert the temperature detection signal from an analog signal to a digital signal, wherein each group of analog-to-digital converters includes multiple detection channels, and each of the bidirectional switching switches also has an acquisition end electrically connected to a corresponding detection channel in the corresponding analog-to-digital converter and an input end electrically connected to the AC signal line.

[0017] Furthermore, each of the electrode units includes a dielectric element for transmitting an AC signal and a temperature sensor having a signal end and a ground end. The temperature sensor is used to detect the temperature of the corresponding electrode unit, and the dielectric element of each electrode unit is short-circuited with the signal end of the temperature sensor.

[0018] Furthermore, each of the electrode units further includes a diode connected in series with the temperature sensor, and the temperature sensor is grounded via the diode connected in series with the temperature sensor.

[0019] Further, the plurality of electrode units are arranged in multiple rows and multiple columns in structure, the flexible circuit board is provided with a connecting portion connecting two adjacent electrode units, wherein the electrode sheet is provided with a spacing formed between two adjacent electrode units in the column direction and in the row direction.

[0020] Further, when detecting the temperature of each electrode unit of the electrode sheet, the plurality of bidirectional switches electrically connected to the electrode sheet are all placed at the collection end, and only one of the plurality of grounding switches electrically connected to the electrode sheet is turned on at the same time, and the rest are all turned off.

[0021] Further, when transmitting an alternating current signal of each electrode unit of the electrode sheet, all or part of the plurality of bidirectional switches electrically connected to the electrode sheet are placed at the input end, and all of the plurality of grounding switches electrically connected to the electrode sheet are turned off.

[0022] Further, the adapter further comprises a first controller connected to the plurality of groups of grounding switches and the plurality of groups of bidirectional switches, respectively, and configured to: control the on-off state of the plurality of grounding switches in each group of grounding switches in turn and in circulation, thereby sequentially and individually turning on each ground line in the plurality of ground lines of the corresponding electrode sheet; and control the switching state of the plurality of bidirectional switches in each group of bidirectional switches, so that each bidirectional switch is placed at the collection end to output a temperature detection signal or each bidirectional switch is placed at the input end to transmit an alternating current signal.

[0023] Further, the adapter further comprises a first communication unit configured to obtain digital signals output by the plurality of groups of analog-to-digital converters and send the digital signals to the electric field generator.

[0024] Further, the electric field generator is further configured to control or adjust the alternating current signal transmitted to the corresponding electrode unit in the plurality of electrode units of the corresponding electrode sheet according to the received digital signals.

[0025] Further, the first communication unit is controlled by the first controller and serially transmits the digital signals converted by the analog-to-digital converters.

[0026] To achieve the above purpose, the present application also provides the following technical solutions: a temperature detection method applied to the tumor electric field treatment system, the method comprising the following steps: turning on all the collection ends of the plurality of two-purpose signal lines corresponding one-to-one to the plurality of column groups of the corresponding electrode sheet; and sequentially and in time turning on each ground line in the plurality of ground lines corresponding one-to-one to the plurality of row groups of the electrode sheet to collect the temperature detection signals of each electrode unit in each row group of the electrode sheet by the two-purpose signal lines in rows.

[0027] To achieve the above object, the present application provides the following technical solutions: A temperature anomaly detection method, wherein the temperature anomaly is determined according to the temperature detection signals of each electrode unit of the electrode sheet obtained by the above method.

[0028] Further, the temperature anomaly determination of the tumor electric field treatment system comprises the following steps: comparing the obtained temperature of each electrode unit with a preset temperature threshold; and determining whether the temperature of the electrode sheet is abnormal according to the comparison result.

[0029] Further, the comparison result comprises not exceeding the preset temperature threshold and exceeding the preset temperature threshold, and whether the temperature of the electrode sheet is abnormal is determined by: when the temperature of one electrode unit exceeds the preset temperature threshold, it is determined that the electrode sheet has a temperature anomaly; or when the temperature of all electrode units of the electrode sheet does not exceed the preset temperature threshold, it is determined that the electrode sheet does not have a temperature anomaly.

[0030] Further, the preset temperature threshold is 40.5-41.5℃.

[0031] Further, the preset temperature threshold is 41-41.5℃.

[0032] Further, the preset temperature threshold is 41℃.

[0033] To achieve the above object, the present application provides the following technical solutions: An alternating current signal application control method for tumor electric field treatment, applied to the tumor electric field treatment system.

[0034] Further, the alternating current signal applied to each electrode unit of the electrode sheet is controlled or adjusted according to the temperature detection signal of each electrode unit of the electrode sheet obtained by the above method.

[0035] Further, the control or adjustment of the alternating current signal applied to each electrode unit of the electrode sheet comprises: comparing the obtained temperature of each electrode unit with a preset temperature threshold; and controlling or adjusting the alternating current signal applied according to the comparison result.

[0036] Further, the control or adjustment of the alternating current signal applied to each electrode unit of the electrode sheet is completed by: when the obtained temperature detection signal of each electrode unit of the electrode sheet does not exceed the preset temperature threshold, continuing to apply the alternating current signal to each electrode unit of the electrode sheet; or when one of the obtained temperature detection signals of each electrode unit of the electrode sheet exceeds the preset temperature threshold, stopping applying the alternating current signal to the electrode unit of the electrode sheet.

[0037] Further, the stopping of applying the alternating current signal to the electrode units of the electrode sheet includes stopping of applying the alternating current signal to all electrode units of the electrode sheet, stopping of applying the alternating current signal to the electrode units of the electrode sheet whose temperature detection signals exceed the preset temperature threshold, and stopping of applying the alternating current signal to all electrode units of the column of the electrode sheet in which the electrode units whose temperature detection signals exceed the preset temperature threshold are located.

[0038] Further, when the application of the alternating current signal to the electrode units of the electrode sheet whose temperature detection signals exceed the preset temperature threshold is stopped, the electrode units of the electrode sheet whose temperature detection signals do not exceed the preset temperature threshold continue to be applied with the alternating current signal.

[0039] Further, when the application of the alternating current signal to all electrode units of the column of the electrode sheet in which the electrode units whose temperature detection signals exceed the preset temperature threshold are located is stopped, all electrode units of the electrode sheet whose temperature detection signals do not exceed the preset temperature threshold and which are located in a different column from the electrode units whose temperature detection signals exceed the preset temperature threshold continue to be applied with the alternating current signal.

[0040] Further, the comparison result includes the condition of not exceeding the preset temperature threshold and the condition of exceeding the preset temperature threshold, and the condition of not exceeding the preset temperature threshold includes the condition of being far below the preset temperature threshold and the condition of being close to the preset temperature threshold.

[0041] Further, when all temperature detection signals of the electrode sheet do not exceed the preset temperature threshold, the application of the alternating current signal to the electrode units of the electrode sheet is continued in the following manner: when the temperature detection signal is far below the preset temperature threshold, the application of the alternating current signal to the electrode units of the electrode sheet is continued in a manner of increasing the voltage or current amplitude of the alternating current signal currently applied to the electrode units of the electrode sheet or in a manner of keeping the voltage or current amplitude of the alternating current signal currently applied to the electrode units of the electrode sheet unchanged; or when the temperature detection signal is close to the preset temperature threshold, the application of the alternating current signal to the electrode units of the electrode sheet is continued in a manner of keeping the voltage or current amplitude of the alternating current signal currently applied to the electrode units of the electrode sheet unchanged or in a manner of decreasing the voltage or current amplitude of the alternating current signal currently applied to the electrode units of the electrode sheet.

[0042] Further, the preset temperature threshold is 40.5-41.5℃.

[0043] Further, the preset temperature threshold is 41-41.5℃.

[0044] Further, the preset temperature threshold is 41℃.

[0045] To achieve the above objectives, the present application also provides the following technical solution: a signal control method for tumor electric field therapy, applied to the aforementioned tumor electric field therapy system.

[0046] Furthermore, the signal for tumor electric field therapy is achieved by combining and controlling the conduction and disconnection of multiple dual-purpose signal lines that correspond one-to-one to each column group of the electrode sheet and are electrically connected to the electrode units of each column group, and multiple ground lines that correspond one-to-one to each row group of the electrode sheet and are electrically connected to the electrode units of each row group, and by using the multiple dual-purpose signal lines electrically connected to each electrode unit of the electrode sheet to enable each electrode unit of the electrode sheet to cyclically switch between applying an alternating current signal and collecting or transmitting a temperature detection signal.

[0047] Furthermore, the process of applying an AC signal to each electrode unit of the electrode sheet includes the following steps: disconnecting the multiple grounding lines that are electrically connected one-to-one to the electrode units of each row group of the electrode sheet, and at the same time connecting the multiple dual-purpose signal lines that are electrically connected one-to-one to the electrode units of each column group of the electrode sheet so that the multiple dual-purpose signal lines electrically connected to the electrode sheet transmit the AC signal to each electrode unit.

[0048] Furthermore, the process of transmitting temperature detection signals to each electrode unit of the electrode sheet includes the following steps: turning on the multiple dual-purpose signal lines electrically connected one by one to the electrode units of each column group of the electrode sheet so that the multiple dual-purpose signal lines electrically connected to the electrode sheet transmit DC signals to each electrode unit; and sequentially turning on one ground line of the multiple ground lines electrically connected one by one to the electrode units of each row group of the electrode sheet so as to complete the transmission of temperature detection signals of each electrode unit in each row group of the electrode sheet row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

[0049] Furthermore, the method also includes the steps of: determining a combined control method for turning on or off the multiple ground lines corresponding to each row group of the electrode sheet and the multiple dual-purpose signal lines corresponding to each column group of the electrode sheet based on the temperature detection signals obtained from each electrode unit; and controlling the working state of each electrode unit of the electrode sheet based on the determined combined control method for turning on or off the multiple ground lines and the multiple dual-purpose signal lines.

[0050] Furthermore, the working state of each electrode unit of the electrode sheet includes one of stopping applying the alternating current signal and continuing to collect the temperature detection signal and stopping collecting the temperature detection signal and continuing to apply the alternating current signal.

[0051] Furthermore, continuing to apply the AC signal includes continuing to apply the AC signal in a manner of increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply the AC signal in a manner of maintaining the voltage or current amplitude of the currently applied AC signal unchanged, or continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal.

[0052] The above description is only an overview of the technical solution of the present application. In order to more clearly understand the technical means of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 A schematic diagram of a framework of the tumor electric field treating system according to the first embodiment of the present application is shown, which shows a schematic diagram of the structure of the electrode sheet according to the first embodiment;

[0054] Figure 2 For use in this application Figure 1 A schematic structural diagram of an alternative embodiment of the electrode sheet of the first embodiment of the tumor electric field treating system is shown;

[0055] Figure 3 For this application Figure 1 The circuit connection diagram of the tumor electric field system is shown in FIG. Figure 1 The electrode sheet of the first embodiment shown or Figure 2 The electrode sheet of the modified embodiment shown in FIG. Figure 1 A circuit connection diagram of the adapter of the first embodiment shown in FIG;

[0056] Figure 4 For this application Figure 3 A schematic block diagram of the internal structure of the adapter shown;

[0057] Figure 5 For this application Figure 1 A schematic block diagram of the internal structure of an electric field generator of a tumor treating field system is shown;

[0058] Figure 6 and Figure 3 Similarly, the circuit connection diagram of the tumor electric field treatment system of the second embodiment of the present application is shown, which shows the electrode sheet and the second embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0059] Figure 7 and Figure 3Similarly, the circuit connection diagram of the tumor therapeutic field system according to the third embodiment of the present application is shown, which shows the circuit connection diagram of the electrode sheet of the third embodiment of the tumor therapeutic field system according to the present application and the adapter of the second embodiment;

[0060] Figure 8 and Figure 3 Similarly, the circuit connection diagram of the tumor therapeutic field system of the fourth embodiment of the present application is shown, which shows the circuit connection diagram of the electrode sheet of the fourth embodiment of the tumor therapeutic field system of the present application and the adapter of the second embodiment;

[0061] Figure 9 for Figure 7 and Figure 8 Schematic block diagram of the internal structure of the adapter used in the second embodiment of the tumor electric field therapy system of the present application;

[0062] Figure 10 and Figure 1 Similarly, FIG. 5 is a schematic diagram of a framework of a tumor electric field treating system according to a fifth embodiment of the present application, which shows a schematic diagram of the structure of the electrode sheet according to the fifth embodiment;

[0063] Figure 11(A) Figure 10 Schematic diagram of a modified embodiment of the electrode sheet of the fifth embodiment of the tumor treating field system of the present application;

[0064] Figure 11(B) is similar to Figure 11(A). Figure 10 Schematic diagram of another alternative embodiment of the electrode sheet of the fifth embodiment of the tumor treating field system of the present application;

[0065] Figure 12 and Figure 3 Similar to Figure 10 A circuit connection diagram of the tumor electric field treatment system is shown in FIG. Figure 10 Schematic diagram of circuit connection between the electrode sheet of the fifth embodiment shown in FIG. 11 or the electrode sheet of the modified embodiment shown in FIG. 11(A) and FIG. 11(B) and the adapter of the third embodiment;

[0066] Figure 13 and Figure 12 Similarly, the circuit connection diagram of the tumor therapeutic field system of the sixth embodiment of the present application is shown, which shows another circuit connection diagram of the electrode sheet of the sixth embodiment of the tumor therapeutic field system of the present application and the adapter of the third embodiment;

[0067] Figure 14 for Figure 12 and Figure 13 Schematic block diagram of the internal structure of the adapter used in the third embodiment of the tumor electric field therapy system of the present application;

[0068] Figure 15 and Figure 12 Similarly, the circuit connection diagram of the tumor therapeutic field system of the seventh embodiment of the present application is another circuit connection diagram of the electrode sheet of the seventh embodiment of the tumor therapeutic field system of the present application and the adapter of the fourth embodiment;

[0069] Figure 16 and Figure 15 Similarly, the circuit connection diagram of the tumor therapeutic field system of the eighth embodiment of the present application is shown, which shows another circuit connection diagram of the electrode sheet of the eighth embodiment of the tumor therapeutic field system of the present application and the adapter of the fourth embodiment;

[0070] Figure 17 for Figure 15 and Figure 16 Schematic block diagram of the internal structure of the adapter used in the fourth embodiment of the tumor electric field therapy system of the present application;

[0071] Figure 18 and Figure 1 Similarly, FIG. 1 is a schematic diagram of a framework of a tumor treating field system according to a ninth embodiment of the present application, which shows a schematic diagram of the structure of the electrode sheet according to the ninth embodiment;

[0072] Figure 19 for Figure 18 The circuit connection diagram of the tumor electric field treatment system is shown in FIG. Figure 18 A schematic diagram of circuit connection between the electrode sheet of the ninth embodiment and the adapter of the fifth embodiment is shown;

[0073] Figure 20 for Figure 19 Schematic block diagram of the internal structure of the adapter used in the fifth embodiment of the tumor electric field therapy system of the present application;

[0074] Figure 21 and Figure 19 Similarly, the circuit connection diagram of the tumor therapeutic field system of the tenth embodiment of the present application is shown, which shows the circuit connection diagram of the electrode sheet of the tenth embodiment of the tumor therapeutic field system of the present application and the adapter of the sixth embodiment;

[0075] Figure 22 for Figure 21 Schematic block diagram of the internal structure of the adapter used in the sixth embodiment of the tumor electric field therapy system of the present application;

[0076] Figure 23 This is a flow chart of a temperature detection method for a tumor electric field therapy system according to an embodiment of the present application;

[0077] Figure 24 This is a flow chart of a method for controlling application of an alternating current signal for tumor electric field therapy according to an embodiment of the present application;

[0078] Figure 25 This is a flow chart of a signal control method for tumor electric field therapy according to an embodiment of the present application;

[0079] Figure 26 This is a flow chart of a method for detecting electrode temperature according to another embodiment of the present application;

[0080] Figure 27 This is a flow chart of a method for applying an alternating current signal for tumor treating field therapy according to another embodiment of the present application;

[0081] Figure 28 Schematic diagram of a flow chart of a method for applying an alternating current signal based on a temperature detection signal according to an embodiment of the present application;

[0082] Figure 29 FIG. 4 is a flow chart of a method for applying an alternating current signal based on a temperature detection signal according to another embodiment of the present application.

[0083] Description of reference numerals:

[0084] Tumor electric field therapy system 100, 100D, 100G, electrode pads 10, 10', 10A, 10B, 10C, 10D, 10D', 10D", 10E, 10F, 10G, 10H, 10J, flexible circuit board 11, 11A, 11B, 11C, 11D, 11E, 11F, 11G, 11H, 11J, connecting portion 111, 111', connecting portion 112, 112', bridging portion 113, 113', electrode unit 12, first cable 13, 13', 13D, 13D', 13D", temperature sensor 14, ground terminal 14-1, signal Terminal 14-2, dielectric element 15, diode 16, grounding line 18, first grounding line 18-1, second grounding line 18-2, third grounding line 18-3, fourth grounding line 18-4, fifth grounding line 18-5, dual-purpose signal line 19, first dual-purpose signal line 19-1, second dual-purpose signal line 19-2, third dual-purpose signal line 19-3, fourth dual-purpose signal line 19-4, fifth dual-purpose signal line 19-5, sixth dual-purpose signal line 19-6, adapter 20, 20A, 20B, 20C, 20D, 20E, second cable 21, first controller 22, analog-to-digital converter 23, voltage divider Resistor 24, grounding switch 25, first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, fourth grounding switch 25-4, fifth grounding switch 25-5, bidirectional switch 26, first bidirectional switch 26-1, second bidirectional switch 26-2, third bidirectional switch 26-3, fourth bidirectional switch 26-4, fifth bidirectional switch 26-5, first communication unit 27, AC signal line 28, first power supply module 29, electric field generator 30, second power supply module 31, second controller 32, second communication unit 33, AC signal generator 34, AC signal switch 35, first AC signal switch 35-1, second AC signal switch 35-2, third AC signal switch 35-3, fourth AC signal switch 35-4, AC signal wire 36, first AC signal wire 36-1, second AC signal wire 36-2, third AC signal wire 36-3, fourth AC signal wire 36-4, first connectors 40, 40A, 40B, 40C, 40D, 40E, first plugs 41, 41', 41D, 41D', 41D", first socket 42, second connector 50, second plug 51, second socket 52. DETAILED DESCRIPTION

[0085] The following embodiments of the technical solution of the present application will be described in detail with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application and are therefore only examples and are not intended to limit the scope of protection of the present application.

[0086] Figure 1FIG. 1 is a schematic diagram of a tumor electric field treatment system 100 according to an embodiment of the present application. Figure 1 As shown, the tumor electric field therapy system 100 includes: at least one pair of electrode sheets 10, an adapter 20 electrically connected to the electrode sheets 10, and an electric field generator 30 electrically connected to the adapter 20. The electric field generator 30 generates an alternating current signal for tumor treatment and applies the alternating current signal to the electrode sheets 10 through the adapter 20, so as to generate an alternating current signal in the paired electrode sheets 10. The adapter 20 is electrically connected between the electrode sheets 10 and the electric field generator 30, and is used to transmit the alternating current signal generated by the electric field generator 30 to the electrode sheets 10. In other words, the electric field generator 30 is capable of generating an alternating current signal, and the alternating current signal generated by the electric field generator 30 is transmitted to each electrode sheet 10 through the adapter 20, so that a therapeutic electric field for treating tumors is generated between the same pair of electrode sheets 10.

[0087] like Figure 1 As shown, in this embodiment, the number of electrode sheets 10 is 4. From the perspective of spatial structural arrangement, each electrode sheet 10 includes a plurality of electrode units 12 that are both axially symmetrically arranged and centrally symmetrically arranged and of the same number, a plurality of connecting portions 111 located between two adjacent electrode units 12, a bridging portion 113 erected between two adjacent connecting portions 111, a wiring portion 112 connected to the bridging portion 113, and a first cable 13 connected to the wiring portion 112. The bridging portion 113 and the wiring portion 112 are arranged vertically to form a "T" shape. The bridging portion 113 is erected between two adjacent connecting portions 111. Each electrode unit 12 of the electrode sheet 10 is electrically connected to the adapter 20 via the first cable 13.

[0088] Each electrode unit 12 has a temperature sensor 14 and a dielectric element 15. The temperature sensor 14 is used to detect the temperature of the part of the patient's body surface to which the electrode unit 12 is applied. It can be a thermistor element or a temperature sensor other than a thermistor, and can be set at any position on the electrode unit 12. The dielectric element 15 is used to apply an AC signal to the patient's tumor site. The dielectric element 15 can be a dielectric ceramic sheet or a polymer dielectric layer composed of a polymer material. In this embodiment, each dielectric element 15 has a through-hole (unnumbered) provided in the middle for accommodating a corresponding temperature sensor 14. Each electrode unit 12 can also include a diode 16 connected in series with the temperature sensor 14, which can prevent the reverse flow of current to prevent the detection signal from other electrode units 12 from affecting the temperature sensor 14. The ground terminal 14-1 of the temperature sensor 14 is connected in series with the anode of the diode 16 and is grounded through the cathode of the diode 16.

[0089] In a first mode, the electrode unit 12 applies an AC signal via the dielectric element 15. In a second mode, the temperature sensor 14 detects or collects the temperature of the patient's body surface to which the corresponding electrode unit 12 is applied. In a third mode, the application of the AC signal and temperature detection and collection cease. The first, second, and third modes do not overlap in time periods. That is, the time periods during which the dielectric element 15 of the electrode unit 12 applies the AC signal are staggered and do not overlap with the time periods during which the temperature sensor 14 detects temperature. The electrode unit 12 can cyclically switch between applying the AC signal via its dielectric element 15 and detecting temperature via its temperature sensor 14, that is, the electrode unit 12 can cyclically switch between the first and second modes. The electrode unit 12 can also cyclically switch between the first, second, and third modes, that is, the electrode unit 12 cyclically switches between applying the AC signal via the dielectric element 15, collecting or detecting temperature via the temperature sensor 14, and then cessation of applying the AC signal and collecting temperature.

[0090] Each electrode sheet 10 includes an electrode array (unnumbered) consisting of 20 electrode units 12. The electrode array (unnumbered) also has a flexible circuit board 11 including a connecting portion 111, a wiring portion 112, and a bridging portion 113. The 20 electrode units 12 are distributed in an electrode array (unnumbered) arranged in four rows and six columns. Specifically, the first and last rows each have four electrode units 12, and the middle two rows each have six electrode units 12. The four electrode units 12 in the first row are respectively located in each of the second to fifth columns, the six electrode units 12 in each of the middle two rows are respectively located in each of the first to sixth columns, and the four electrode units 12 in the last row are also respectively located in each of the second to fifth columns.

[0091] The connecting portion 111 is located only between two adjacent electrode units 12 arranged in the column direction in each of the third and fourth columns, and between two adjacent electrode units 12 in the row direction, excluding the two electrode units 12 in the third and fourth columns. That is, the two adjacent electrode units 12 in the third and fourth columns are connected only in the column direction via the connecting portion 111, and are disconnected in the row direction, not connected by the connecting portion 111. The electrode units 12 in each of the first, second, fifth, and sixth columns are connected only to the electrode units 12 adjacent in the row direction via the horizontally arranged connecting portion 111, and are disconnected in the column direction from the electrode units 12 adjacent to them. In other words, the two adjacent electrode units 12 in the first, second, fifth, and sixth columns are disconnected.

[0092] The electrode units 12 in the third column and the longitudinally disposed connecting portions 111 between the electrode units 12 in that column, as well as the electrode units 12 in the fourth column and the longitudinally disposed connecting portions 111 between the electrode units 12 in that column, constitute the backbone 114 of the electrode array (unnumbered). The connecting portions 111 located on opposite sides of the electrode units 12 in the third and fourth columns, connected to the electrode units 12 in the third and fourth columns via the transversely disposed connecting portions 111, and the electrode units 12 connected to the transversely disposed connecting portions 111, constitute the branches 115 of the electrode array (unnumbered). In other words, in this embodiment, the electrode array (unnumbered) includes two backbones 114 and a plurality of branches 115 extending laterally from the two backbones 114. Each branch 115 has a free end distal from the backbone 114. The free ends of adjacent branches 115 are disconnected, and the position and distance between adjacent branches 115 can be freely adjusted according to actual usage scenarios. Specifically, one trunk 114 is composed of the electrode units 12 in the third column and the longitudinally arranged connecting portions 111 between adjacent electrode units 12 in the column. Another trunk 114 is composed of the electrode units 12 in the fourth column and the longitudinally arranged connecting portions 111 between adjacent electrode units 12 in the column. The remaining electrode units 12 connected to the trunk 114 via the transversely arranged connecting portions 111 and the transversely arranged connecting portions 111 are all branches 115.

[0093] Specifically, the branches 115 are: a connecting portion 111 extending laterally to the left from the electrode unit 12 in the first row of the third column and located in the first row, and an electrode unit 12 connected to the connecting portion 111 and located in the second column of the first row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the second row of the third column and located in the second row, and two electrode units 12 located in the first column of the second row and the second column of the second row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the third row of the third column and located in the third row, and two electrode units 12 located in the first column of the third row and the second column of the third row; a connecting portion 111 extending laterally to the left from the electrode unit 12 in the fourth row and located in the fourth row, and The electrode unit 12 in the second column of the fourth row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the first row of the fourth column and located in the first row, and the electrode unit 12 located in the fifth column of the first row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the second row of the fourth column and located in the second row, and two electrode units 12 located in the fifth column of the second row and the sixth column of the second row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the third row of the fourth column and located in the third row, and two electrode units 12 located in the fifth column of the third row and the sixth column of the third row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the fourth row of the fourth column and located in the fourth row, and the electrode unit 12 located in the fifth column of the fourth row.

[0094] The electrode array (unnumbered) is divided into a symmetrical left portion comprising three columns on the left and a right portion comprising three columns on the right, and the left portion and the right portion are connected only by a bridge portion 113. The left portion is composed of a trunk 114 located in the third column and a plurality of branches 115 extending laterally to the left from the trunk 114, and the right portion is composed of a trunk 114 located in the fourth column and a plurality of branches 115 extending laterally to the right from the trunk 115. The two trunks 114 are connected by a bridge portion 113 provided therebetween. Specifically, the two trunks 114 are electrically connected by a bridge portion 113 provided between a connection portion 111 connecting the electrode unit 12 in the second row of the third column and the electrode unit 12 in the third row of the third column and a connection portion 111 connecting the electrode unit 12 in the second row of the fourth column and the electrode unit 12 in the third row of the fourth column. The connecting portion 111 connecting the electrode unit 12 in the second row of the third column with the electrode unit 12 in the third row of the third column, the connecting portion 111 connecting the electrode unit 12 in the second row of the fourth column with the electrode unit 12 in the third row of the fourth column, and the bridging portion 113 are generally arranged in an "H" shape. In other embodiments, the bridging portion 113 may also be provided between an electrode unit 12 in the third column and an electrode unit 12 in the fourth column. Alternatively, the bridging portion 113 may be provided between two electrode units 12 in the third and fourth columns that are adjacent in the row direction.

[0095] Each electrode unit 12 can be divided into an electrode unit 12 located at the periphery and an electrode unit 12 located at the center according to its position in the electrode array (unnumbered). The electrode units 12 located at the periphery include four electrode units 12 located in the first row, two electrode units 12 located at opposite ends of the second row, two electrode units 12 located at opposite ends of the third row, and four electrode units 12 located in the fourth row. The electrode units 12 located at the center include four electrode units 12 located in the middle of the second row and four electrode units 12 located in the middle of the third row. Some adjacent two electrode units 12 in the plurality of electrode units 12 located at the periphery are connected by a laterally arranged connecting portion 111, and some adjacent two electrode units 12 are arranged in a disconnected state. Among the plurality of electrode units 12 located at the periphery, the adjacent two electrode units 12 connected by the connecting portion 111 are two electrode units 12 that are adjacent in some rows. Specifically, among the plurality of electrode units 12 located at the periphery, two adjacent electrode units 12 in the column direction and two adjacent electrode units 12 in the diagonal direction are all disconnected; some adjacent electrode units 12 in the row direction are also disconnected; and only some adjacent electrode units 12 in the row direction are connected by a laterally extending connection portion 111. Among the plurality of electrode units 12 located at the center, only two adjacent electrode units 12 in the column direction on the trunk 114 are connected by a longitudinally arranged connection portion 111, and only two adjacent electrode units 12 in the row direction on the branches 115 are connected by a laterally arranged connection portion 111.

[0096] The electrode array (unnumbered) also includes spaces (unnumbered) formed between the spaced electrode units 12. These spaces allow moisture from the patient's body to escape, heat exchange between the patient's skin and the surrounding environment, and allow the patient's skin to breathe freely. They also allow for flexible adjustment of the position and spacing between the branches 115 and prevent wrinkles when the electrode sheet 10 is applied. The spaces (unnumbered) include a first space D1 between the two trunks 114 and a second space D2 between the branches 115. The first space D1 is located between the third and fourth columns of electrode units 12, while the second space D2 is located between adjacent rows of electrode units 12. That is, going up along the row, the electrode unit 12 located in the third column is disconnected from the adjacent electrode unit 12 located in the fourth column, and no connecting portion 111 is provided, but the aforementioned first interval D1 is formed; and going up along the column, only the two adjacent electrode units 12 in the third and fourth columns are connected by the connecting portion 111, and the two adjacent electrode units 12 in the column direction in each of the other four columns are not connected by the connecting portion 111 but form the aforementioned second interval D2. The setting of the first and second intervals D1 and D2 can also increase the degree of freedom of some electrode units 12, and can also avoid wrinkles when attaching the electrode sheet 10.

[0097] In some other embodiments, the tumor electric field therapy system 100 may also have more or fewer electrode sheets 10. In some other embodiments, each pair of electrode sheets 10 has the same number of electrode units 12, and different pairs of electrode sheets 10 may have different numbers of electrode units 12. In some other embodiments, the 20 electrode units 12 may also be arranged in other ways. Of course, in some other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In short, the implementation of the present application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0098] Figure 2 The electrode sheet 10' shown is Figure 1 A variation of the electrode sheet 10 shown in FIG. 1 has the same spatial structure as the electrode sheet 10 and also includes a plurality of electrode units 12' arranged at intervals, a plurality of connecting portions 111' located between two adjacent electrode units 12', a wiring portion 112' connected to the bridging portion 113', a first cable 13' connected to the wiring portion 112', a first gap D1' formed between the third column of electrode units 12' and the fourth column of electrode units 12', and a second gap D2' formed between adjacent rows of electrode units 12'. The only difference is that: the two electrode units 12' adjacent to each other in the column direction in the fourth column are both disconnected and not connected by the longitudinally arranged connecting portion 111', but the two electrode units 12' adjacent to each other in the column direction in the fifth column are connected by the longitudinally arranged connecting portion 111', and each electrode unit 12' in the fourth column is connected to the electrode unit 12' in the fifth column and adjacent to each other in the row direction through the transversely arranged connecting portion 111'; and the bridging portion 113' is connected between the two electrode units 12' located in the third row and the third column and the electrode unit 12' located in the third row and the fourth column.

[0099] Figure 3 for Figure 1 The diagram shows a circuit connection diagram of the first embodiment of the electrode sheet 10 or its variant embodiment 10' and the adapter 20 of the first embodiment for use in the tumor electric field therapy system 100 of the present application. It is worth noting that: Figure 3 The arrangement of the electrode units 12 is shown to more clearly illustrate the electrical connection between an electrode sheet 10 and the adapter 20. Figure 3 The arrangement of the electrode units 12 shown does not represent the arrangement of the electrode units 12 in the spatial structure. The following describes the circuit connection by taking the electrode sheet 10 in the first embodiment as an example. Figure 1 as well as Figure 3The flexible circuit board 11 is embedded with multiple conductive traces 18 and 19, including multiple grounding traces 18 and multiple dual-purpose signal traces 19. The first cable 13 includes multiple conductors (not shown) that are electrically connected to the multiple grounding traces 18 and multiple dual-purpose signal traces 19 of the flexible circuit board 11 in a one-to-one correspondence. The total number of grounding traces 18 and dual-purpose signal traces 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of conductors in the first cable 13 does not exceed 10.

[0100] In this embodiment, each electrode sheet 10 is provided with 20 electrode units 12. The 20 electrode units 12 are arranged in order of 1 to 20 for circuit connection, divided into five row groups and four column groups. That is, the 20 electrode units 12 are arranged in five rows and four columns for circuit connection. The temperature sensor 14 of each electrode unit 12 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and temperature sensor 14 of each electrode unit 12 are soldered to the flexible circuit board 11, and each dielectric element 15 is short-circuited with the signal terminal 14-2 of the corresponding temperature sensor 14. Since the electrode units 12 are arranged in five rows and four columns for circuit connection, and each electrode unit includes a corresponding dielectric element 15 and a corresponding temperature sensor 14, the multiple temperature sensors 14 are also arranged in five rows and four columns for circuit connection, and the multiple dielectric elements 15 are also arranged in five rows and four columns for circuit connection. It should be noted that the arrangement here is to more clearly show the electrical connection between the electrode sheet 10 and the adapter 20, and does not represent the arrangement of the electrode unit 12 in the spatial structure. The spatial structure may be as follows: Figure 1 The structure shown is generally an array, but may also be other structures, such as petal-shaped or scattered, and may be regular or irregular. The dielectric element 15 is configured to apply an alternating electric field to the patient's tumor site. The temperature sensor 14 is configured to detect the temperature of the patient's body surface to which the electrode sheet 10 is applied and output a temperature detection signal to the adapter 20. In this embodiment, the multiplexed signal lines 19 of the flexible circuit board 11 are respectively provided in a one-to-one correspondence with the multiple column groups of the electrode units 12, and are configured to transmit the alternating current signal generated by the electric field generator 30 to the dielectric elements 15 in each electrode unit 12 in the corresponding column group. That is, the dielectric elements 15 in the same column group are short-circuited by the same dual-purpose signal line 19 of the flexible circuit board 11, and the dielectric elements 15 in different column groups are connected in parallel by different dual-purpose signal lines 19 of the flexible circuit board 11. The dual-purpose signal lines 19 of the flexible circuit board 11 are electrically connected to corresponding wires in the first cable 13, and then electrically connected to the electric field generator 30 via the adapter 20. In other words, the dual-purpose signal lines 19 of the flexible circuit board 11 receive the AC signal generated by the electric field generator 30 through the first cable 13 and the adapter 20.

[0101] Multiple grounding wires 18 are provided in a one-to-one correspondence with the multiple row groups of electrode units 12. These wires are used to sequentially short-circuit the temperature sensors 14 of each electrode unit 12 in each row group to ground. Specifically, the ground terminals 14-1 of the temperature sensors 14 in the same row group are all short-circuited via the same grounding wire 18 on the flexible circuit board 11. The ground terminals 14-1 of the temperature sensors 14 in different row groups are each connected to ground in parallel via different grounding wires 18 on the flexible circuit board 11. During the temperature detection period or in the second mode, only one of the multiple grounding wires 18 is connected at any one time; the remaining grounding wires are disconnected.

[0102] Each of the multiplexed dual-purpose signal lines 19 is further configured to transmit a DC signal to the temperature sensor 14 in each electrode unit 12 in the corresponding column group to collect and transmit the detected temperature signal. The signal terminals 14-2 of the temperature sensors 14 in different column groups are connected in parallel via different dual-purpose signal lines 19 on the flexible circuit board 11. The signal terminals 14-2 of the temperature sensors 14 in the same column group are all short-circuited to the same dual-purpose signal line 19 on the flexible circuit board 11. Specifically, each dual-purpose signal line 19 is configured to short-circuit the signal terminal 14-2 of the temperature sensor 14 in at most one electrode unit 12 in each row group to an external device for receiving detection signals. Each of the multiplexed dual-purpose signal lines 19 is connected to a different signal terminal 14-2 of each temperature sensor 14 to prevent duplicate signals from being subsequently output by the dual-purpose signal lines 19. That is, when the number of electrode units 12 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to the signal end 14-2 of the temperature sensor 14 of a different electrode unit 12 in the row group. When the number of electrode units 12 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal end 14-2 of the temperature sensor 14 of an electrode unit 12, and each of the remaining dual-purpose signal lines 19 is electrically connected to the signal end 14-2 of the temperature sensor 14 of a different electrode unit 12 in the row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The dual-purpose signal lines 19 of the flexible circuit board 11 receive the DC signal from the adapter 20 or the electric field generator 30 via the first cable 13, and transmit the collected or detected temperature signal to the adapter 20, and then transmit it to the electric field generator 30 via the adapter 20.

[0103] In this embodiment, when each electrode unit 12 is equipped with a temperature sensor 14 for temperature detection, the above-mentioned circuit design is used to reduce the number of conductors of the first cable 13, thereby avoiding the cable becoming thicker and the cable becoming harder, which increases the difficulty of fixing the cable; at the same time, it is avoided that the increase in the number of conductors of the first cable 13 affects the adhesion effect between the electrode sheet 10 and the body surface corresponding to the tumor site of the patient. The grounding wire 18 and the dual-purpose signal wire 19 embedded in the flexible circuit board 11 are a total of 9 lines. Specifically, in this embodiment, the grounding wire 18 embedded in the flexible circuit board 11 is 5 lines, and the dual-purpose signal wire 19 is 4 lines. In other embodiments, the grounding wire 18 and the dual-purpose signal wire 19 embedded in the flexible circuit board 11 can also have other numbers according to the circuit arrangement and number differences of the electrode units 12 in different electrode sheets, which will be specifically explained in subsequent embodiments.

[0104] In the tumor electric field therapy system 100, the number of conductive lines electrically connected to the ground line 18 is related to the number M of row groups of the electrode units 12, which can be greater than or equal to the number of row groups of the electrode units 12, where M is a positive integer. In the tumor electric field therapy system 100, the number of conductive lines electrically connected to the dual-purpose signal lines 19 is related to the number N of column groups of the electrode units 12, which can be greater than or equal to the number of column groups of the electrode units 12, where N is a positive integer. The number of lines L embedded in the flexible circuit board 11 of the electrode sheet 10 is equal to the sum of the number of ground lines 18 and the number of dual-purpose signal lines 19. In this embodiment, the number of ground lines 18 is equal to the number M of row groups of the electrode units 12; the number of dual-purpose signal lines 19 is equal to the number N of column groups of the electrode units 12.

[0105] exist Figure 3In the illustrated embodiment, specifically, the electrode sheet 10 of this embodiment includes five grounding wires 18, each of which is used to ground the ground terminals 14-1 of the temperature sensors 14 in the same row group. The five grounding wires 18 of the electrode sheet 10 are respectively a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3, a fourth grounding wire 18-4, and a fifth grounding wire 18-5. Among the five row groups of the electrode sheet 10, the first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, the third row group includes electrode units 12-9 to 12-12, the fourth row group includes electrode units 12-13 to 12-16, and the fifth row group includes electrode units 12-17 to 12-20. Specifically, the first grounding wire 18-1 is used to ground the electrode units 12-1 to 12-4 in the first row group; the second grounding wire 18-2 is used to ground the electrode units 12-5 to 12-8 in the second row group; the third grounding wire 18-3 is used to ground the electrode units 12-9 to 12-12 in the third row group; the fourth grounding wire 18-4 is used to ground the electrode units 12-13 to 12-16 in the fourth row group; and the fifth grounding wire 18-5 is used to ground the electrode units 12-17 to 12-20 in the fourth row group. It should be noted that these grounding wires 18 can be selectively closed or opened, which can be achieved by connecting each grounding wire 18 in series with a switch, which will be described in detail below. The above-mentioned "grounding the electrode unit 12" can refer to grounding the ground terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or it can refer to connecting the diode 16 in series with the temperature sensor 14 of the same electrode unit 12 and grounding them together. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in each row group and connects them to the ground.

[0106] Continue to refer Figure 3As shown, the electrode sheet 10 of this embodiment also includes four dual-purpose signal lines 19. One end of each dual-purpose signal line 19 is connected to all electrode units 12 in each column group, and the other end is connected to an adapter 20 for receiving temperature detection signals and transmitting AC signals. In other words, for each row group, each dual-purpose signal line 19 can choose to connect to one of the electrode units 12 or not connect to any electrode unit 12 in the row group to avoid the dual-purpose signal line 19 from subsequently outputting duplicate signals. Specifically, the four dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, and a fourth dual-purpose signal line 19-4. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the five electrode units 12, namely, the electrode unit 12-1, the electrode unit 12-5, the electrode unit 12-9, the electrode unit 12-13, and the electrode unit 12-17, and the signal end 14-2 of the temperature sensor 14 of each of the five electrode units 12; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the five electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-6, the electrode unit 12-10, the electrode unit 12-14, and the electrode unit 12-18, and the signal end 14-2 of the temperature sensor 14 of each of the five electrode units 12; One end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric elements 15 of each of the five electrode units 12 (electrode unit 12-3, electrode unit 12-7, electrode unit 12-11, electrode unit 12-15, and electrode unit 12-19), as well as the signal terminals 14-2 of their respective temperature sensors 14. One end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric elements 15 of each of the five electrode units 12 (electrode unit 12-4, electrode unit 12-8, electrode unit 12-12, electrode unit 12-16, and electrode unit 12-20), as well as the signal terminals 14-2 of their respective temperature sensors 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 and signal terminals 14-2 of the temperature sensors 14 of the electrode units 12 in the same column group, allowing for connection to external devices. It should be noted that these dual-purpose signal lines 19 can selectively transmit AC signals or receive temperature detection signals. This can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switch 26 and coordinating the closing or opening of the grounding line 18. This will be described in detail below.

[0107] Multiple ground lines 18 and multiplexed signal lines 19 are conductive traces embedded within the flexible printed circuit board 11. The flexible printed circuit board 11 is electrically connected to the first cable 13. The multiple ground lines 18 and multiplexed signal lines 19 embedded within the flexible printed circuit board 11 are electrically connected to corresponding wires (not shown) within the first cable 13.

[0108] The tumor electric field therapy system 100 of this embodiment includes at least one pair of the above-mentioned electrode sheets 10, an adapter 20 electrically connected to the electrode sheets 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode sheets 10 and the electric field generator 30. The electric field generator 30 provides an AC signal or a DC signal to the dielectric elements 15 in the multiple electrode units 12 of the electrode sheet 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode sheet 10, and is used to receive temperature detection signals output by the temperature sensors 14 in the multiple electrode units 12. The adapter 20 is configured to transmit the AC signal generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode sheet 10, and is also configured to transmit a DC signal to the dual-purpose signal line 19 of the electrode sheet and receive the temperature detection signal output by the multiple dual-purpose signal line 19 of the electrode sheet 10.

[0109] refer to Figure 3 and Figure 4As shown, the adapter 20 includes: a first controller 22, multiple groups of analog-to-digital converters 23 connected to the first controller 22, multiple groups of voltage transformers 24 corresponding to the multiple groups of analog-to-digital converters 23, multiple groups of grounding switches 25 and multiple groups of bidirectional switching switches 26, a first communication unit 27, multiple AC signal lines 28 connected to the multiple groups of bidirectional switching switches 26 in a one-to-one manner, and a first power supply module 29 connected to the first communication unit 27, the first controller 22 and the multiple groups of analog-to-digital converters 23. The first power supply module 29 provides a DC power supply VCC for each electronic component of the adapter 20. The adapter 20 also includes multiple circuit lines (unnumbered). The multiple circuit lines (unnumbered) are electrically connected to the multiple grounding lines 18 and the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode sheet 10 through the first cables 13 of the corresponding electrode sheet 10. The multiple circuit lines (unnumbered) include multiple AC signal lines 28 that transmit alternating current signals to corresponding electrode sheets 10 and are electrically connected to the multiplexed signal lines 19 within the flexible circuit boards 11 of the corresponding electrode sheets 10, multiple circuit lines (unnumbered) that are electrically connected one-to-one with the multiplexed signal lines 19 within the flexible circuit boards 11 of the corresponding electrode sheets 10 and are used to power the temperature sensors 14 of the electrode sheets 10 or transmit temperature detection signals for the electrode sheets 10, and multiple circuit lines (unnumbered) that are electrically connected one-to-one with the multiple ground lines 18 within the flexible circuit boards 11 of the corresponding electrode sheets 10. The number P of circuit lines electrically connected by the adapter 20 to one electrode sheet 10 is equal to the sum of the number of rows M and the number of columns N of the electrode units 12 of the electrode sheet 10 plus 1; the number H of circuit lines electrically connected by the adapter 20 to X electrode sheets 10 is equal to X times the number of circuit lines electrically connected to a single electrode sheet 10, that is, H = XP = X*(M+N+1). The number of grounding switches 25 and the number of bidirectional switches 26 are both related to the number of electrode sheets 10. The number of grounding switches 25 and the number of bidirectional switches 26 are the same and no less than the number of electrode sheets 10. Preferably, the number of grounding switches 25 and the number of bidirectional switches 26 are both the same as the number of electrode sheets 10. The following detailed description will only use the example of an electrode sheet 10 having 20 electrode units 12 and the adapter 20 for electrical connection.

[0110] Each group of grounding switches 25 is provided with a plurality of grounding switches 25, and the plurality of grounding switches 25 are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multi-way grounding lines 18 of the corresponding electrode sheet 10, and are configured to control the conduction or disconnection of the multi-way grounding lines 18. The circuit lines (not numbered) that are electrically connected to the multi-way grounding lines 18 of the electrode sheet 10 are grounded at one end close to the grounding switch 25. The number of grounding switches 25 in each group of grounding switches 25 is related to the number of grounding lines 18 of the flexible circuit board 11 of the corresponding electrode sheet 10, and the two are equal in this embodiment.Figure 3 As shown, in this embodiment, each group of grounding switches 25 includes multiple grounding switches 25, five in this embodiment, namely a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, a fourth grounding switch 25-4, and a fifth grounding switch 25-5. The multiple grounding switches 25 in each group control the closing or opening of the corresponding grounding wire 18 of each electrode sheet 10. The first grounding switch 25-1 is used to control the closing or disconnection of the first grounding line 18-1 of the corresponding electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the four electrode units 12, electrode units 12-1 to electrode units 12-4, in the first row group of the electrode sheet 10; the second grounding switch 25-2 is used to control the closing or disconnection of the second grounding line 18-2 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the four electrode units 12, electrode units 12-5 to electrode units 12-8, in the second row group of the electrode sheet 10; the third grounding switch 25-3 is used to control the closing or disconnection of the third grounding line 18-3 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control The fourth grounding switch 25-4 is used to control the closing or disconnection of the fourth grounding line 18-4 of the electrode sheet 10, and can cooperate with the corresponding set of two-way switches 26 to control the powering on and off of the temperature sensors 14 of the four electrode units 12 in the fourth row of the electrode sheet 10, from electrode units 12-13 to electrode units 12-16. The fifth grounding switch 25-5 is used to control the closing or disconnection of the fifth grounding line 18-5 of the electrode sheet 10, and can cooperate with the corresponding set of two-way switches 26 to control the powering on and off of the temperature sensors 14 of the four electrode units 12 in the fifth row of the electrode sheet 10, from electrode units 12-17 to electrode units 12-20. The above-mentioned grounding switch 25 can be a mechanical switch, such as a relay. The grounding switch 25 may also be an electronic switch, and each grounding switch 25 may be opened and closed by the first controller 22 of the adapter 20 .

[0111] In this embodiment, the multiple sets of grounding switches 25 are all electronic switches. The first controller 22 is in communication with the multiple sets of grounding switches 25 and is configured to sequentially and cyclically control the opening and closing states of the multiple grounding switches 25 in each set of grounding switches 25 . This in turn sequentially connects each of the multiple grounding wires 18 of the corresponding electrode sheet 10 and coordinates the switching of the corresponding bidirectional switch 26 to sequentially and time-sharedly collect the patient's body surface temperature detected by all temperature sensors 14 on the electrode sheet 10 . The number of grounding switches 25 in each set is equal to the number of grounding wires 18 on the flexible circuit board 11 of the corresponding electrode sheet 10 .

[0112] Each set of two-way switches 26 is provided with a plurality of two-way switches 26. The plurality of two-way switches 26 in each set are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multiplexed dual-purpose signal lines 19 of the corresponding electrode sheet 10. The number of two-way switches 26 in each set of two-way switches 26 is related to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10, and is greater than or equal to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10. Figure 3 In the illustrated embodiment, the two are equal. Each bidirectional switch 26 has two terminals labeled 1 and 2. The acquisition terminals 1 of the multiple bidirectional switches 26 in the same group are electrically connected to corresponding detection channels of the multiple detection channels of the corresponding group of analog-to-digital converters 23. The input terminals 2 of each bidirectional switch 26 in the same group are electrically connected to the same corresponding AC signal line 28. Each bidirectional switch 26 is configured to control whether the multiplexed signal line 19 is connected to the corresponding AC signal line 28 to transmit an alternating current signal, or to the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14.

[0113] like Figure 3As shown, taking the electrical connection between one electrode sheet 10 and the adapter 20 as an example, in this embodiment having 20 electrode units 12, the plurality of bidirectional switches 26 are respectively a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, and a fourth bidirectional switch 26-4. The plurality of bidirectional switches 26 in the same group each control a corresponding one of the multiplexed signal lines 19 of the same electrode sheet 10 to switch between transmitting an AC signal and transmitting a temperature detection signal. Specifically, the first bidirectional switch 26-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode sheet 10 between transmitting the AC signal and transmitting the temperature detection signal, thereby controlling the conduction of the dielectric elements 15 of the electrode units 12-1, 12-5, 12-9, 12-13, and 12-17 in the first column group of the electrode sheet 10 and the conduction of the dielectric elements 15 of the electrode units 12-1, 12-5, 12-9, 12-13, and 12-17 in the first column group. The switching between the conduction of the signal end 14-2 of each temperature sensor 14 of 7 and the corresponding first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5 is coordinated to enable the first column of electrode units 12-1, electrode unit 12-5, electrode unit 12-9, electrode unit 12-13, and electrode unit 12-17 to transmit an AC signal to the patient or output the temperature detection signal collected by the temperature sensor 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The second bidirectional switch 26-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode sheet 10 between transmitting the AC signal and transmitting the temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-2, the electrode unit 12-6, the electrode unit 12-10, the electrode unit 12-14, and the electrode unit 12-18 in the second column group of the electrode sheet 10 and the conduction of the electrode unit 12-2, the electrode unit 12-6, the electrode unit 12-10, the electrode unit 12-14, and the electrode unit 12-18 in the second column group. The switching between the conduction of the signal terminal 14-2 of each temperature sensor 14 and the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, fourth grounding switch 25-4, and fifth grounding switch 25-5 is coordinated to enable the second column of electrode units 12-2, 12-6, 12-10, 12-14, and 12-18 to transmit an AC signal to the patient or output the temperature detection signal collected by the temperature sensor 14 of these electrode units 12 to the corresponding analog-to-digital converter 23;The third bidirectional switch 26-3 is used to control the switching of the third dual-purpose signal line 19-3 of the corresponding electrode sheet 10 between transmitting the AC signal and transmitting the temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-3, the electrode unit 12-7, the electrode unit 12-17, the electrode unit 12-15, and the electrode unit 12-19 in the third column group of the electrode sheet 10 and the conduction of the electrode unit 12-3, the electrode unit 12-7, the electrode unit 12-11, the electrode unit 12-15, and the electrode unit 12-19 in the third column group. The switching between the conduction of the signal end 14-2 of each temperature sensor 14 and the corresponding first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5 are coordinated to enable the third column of electrode units 12-3, 12-7, 12-11, 12-15, and 12-19 to transmit an AC signal to the patient or output the temperature detection signal collected by the temperature sensor 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The fourth bidirectional switch 26-4 is used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode sheet 10 between transmitting the alternating current signal and transmitting the temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-4, the electrode unit 12-8, the electrode unit 12-12, the electrode unit 12-16, and the electrode unit 12-20 in the fourth column group of the electrode sheet 10 and the conduction of the electrode unit 12-4, the electrode unit 12-8, the electrode unit 12-12, the electrode unit 12-16, and the electrode unit 12-20 in the fourth column group. The switching between the conduction of the signal terminals 14-2 of each temperature sensor 14 and the switching between the conduction and the coordination with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, fourth grounding switch 25-4, and fifth grounding switch 25-5 enables the fourth column of electrode units 12-4, 12-8, 12-12, 12-16, and 12-20 to transmit an AC signal to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. When the input terminal 2 of each set of bidirectional switches 26 is on and the acquisition terminal 1 is off, the AC signal can be transmitted to the dielectric element 15 of each electrode unit 12 of the corresponding electrode sheet 10. When the acquisition terminal 1 of each set of bidirectional switches 26 is on and the input terminal 2 is off, the bidirectional switches 26 can coordinate with each grounding switch 25 in the corresponding set of grounding switches 25 to transmit the temperature detection signals collected by the temperature sensors 14 of each electrode sheet 10 in a time-sharing manner. The bidirectional switch 26 can be a mechanical switch, such as a relay. Alternatively, the bidirectional switch 26 can be an electronic switch. The switching between the acquisition terminal 1 and the input terminal 2 of each bidirectional switch 26 can be controlled by the first controller 22 of the adapter 20.

[0114] In this embodiment, the plurality of sets of bidirectional switches 26 are all electronic switches. The first controller 22 is in communication with the plurality of sets of bidirectional switches 26 and is configured to control the plurality of bidirectional switches 26 in each set of bidirectional switches 26 to switch between their respective acquisition terminals 1 and input terminals 2, and to coordinate with the closing or opening of the corresponding grounding switches 25 to continuously monitor the patient's body surface temperature detected by all temperature sensors 14 on the electrode sheet 10 or to transmit an AC signal to the patient.

[0115] In this embodiment, each group of analog-to-digital converters 23 is electrically connected to the collection terminals 1 of the plurality of bidirectional switches 26 in the corresponding group of bidirectional switches 26 via a multi-channel circuit line (not numbered) within the adapter 20, and is configured to receive the temperature detection signal transmitted by the multiplexed signal line 19 of the corresponding electrode sheet 10, and convert the temperature detection signal from an analog signal to a digital signal. Each group of analog-to-digital converters 23 includes a plurality of detection channels A, B, C, and D, each detection channel A, B, C, and D being connected to a corresponding one of the multiplexed signal lines 19 via the corresponding bidirectional switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of column groups of the electrode units 12 of the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switches 26 in the corresponding group of bidirectional switches 26, which is not less than the number of column groups of the electrode units 12 of the corresponding electrode sheet 10. like Figure 3 As shown, each set of analog-to-digital converters 23 includes a total of four detection channels A, B, C, and D, namely the first detection channel A, the second detection channel B, the third detection channel C, and the fourth detection channel D. The first detection channel A is connected to the first dual-purpose signal line 19-1 via the acquisition terminal 1 of the first bidirectional switch 26-1, the second detection channel B is connected to the second dual-purpose signal line 19-2 via the acquisition terminal 1 of the second bidirectional switch 26-2, the third detection channel C is connected to the third dual-purpose signal line 19-3 via the acquisition terminal 1 of the third bidirectional switch 26-3, and the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 via the acquisition terminal 1 of the fourth bidirectional switch 26-4. Each detection channel A, B, C, and D is used to receive the temperature detection signal collected by the temperature sensor 14 of the electrode unit 12 connected to the corresponding dual-purpose signal line 19. In addition, each detection channel A, B, C, D is connected to a first power module 29 for providing a detection voltage to the detection channel A, B, C, D via a corresponding voltage divider resistor 24 in the adapter 20. The first power module 29 provides a DC signal.

[0116] In this embodiment, the first communication unit 27 is configured to obtain the digital signals output by the multiple analog-to-digital converters 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage, current, or power of the AC signal provided to the multiple electrode units 12 of the electrode sheet 10 based on the received digital signals. For example, when any of the multiple digital signals received exceeds a preset threshold, it indicates that the temperature of the human body surface to which the corresponding dielectric element 15 is applied, detected by at least one temperature sensor 14 in the electrode sheet 10, exceeds a preset threshold temperature (e.g., 41°C, 42°C, etc.). At this time, the voltage, current, or power of the AC signal output by the electric field generator 30 can be appropriately reduced to prevent the electrode units 12 of the electrode sheet 10 from becoming too hot when the AC signal is applied, thereby causing low-temperature burns to the patient's skin. The above-mentioned preset threshold temperature and preset threshold value can be determined based on the human body safety threshold. The first communication unit 27 is controlled by the first controller 22 and serially transmits the digital signals converted by the multiple analog-to-digital converters 23. In this embodiment, the preset temperature threshold may be a value within the range of 36°C-45°C.

[0117] refer to Figure 4 as well as Figure 5 In this embodiment, the first power supply module 29 is electrically connected to the second power supply module 31 of the electric field generator 30 and is configured to supply power to the first controller 22, the multiple analog-to-digital converters 23, and the first communication unit 27 of the adapter 20. A first connector 40 is provided between each electrode sheet 10 and the adapter 20. The first connector 40 is suitable for connecting the corresponding electrode sheet 10 to the adapter 20. Figure 1 As shown, the first connector 40 includes a first plug 41 located at the end of the first cable 13 away from the electrode sheet 10, and a first socket 42 located on the adapter 20. The first plug 41 and the first socket 42 are push-type spring connectors, meaning that the first connector 40 uses a connector to connect the adapter 20 to the electrode sheet 10. Each first cable 13 has four wires electrically connected to the bidirectional switches 26 in a corresponding group of bidirectional switches 26, and five wires electrically connected to the grounding switches 25 in a corresponding group of grounding switches 25. In other words, each first connector 40 is electrically connected to a corresponding group of bidirectional switches 26-1, 26-2, 26-3, and 26-4 and a corresponding group of grounding switches 25-1, 25-2, 25-3, 25-4, and 25-5 of the adapter 20 via nine wires, and is connected to the electric field generator 30 via a corresponding AC signal line 28 of the adapter 20.

[0118] A second connector 50 is provided between the adapter 20 and the electric field generator 30. The second connector 50 is adapted to connect the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 located at the end of the second cable 21 away from the first controller 22 and a second socket 52 located on the electric field generator 30. The second plug 51 and the second socket 52 are spring-loaded connectors, meaning that the second connector 50 connects the adapter 20 to the electric field generator 30 using a connector-type design. Each first connector 40, such as X1, Y1, X2, and Y2, is connected to the second connector 50 via a corresponding AC signal line 28. Each first connector 40, such as X1, Y1, X2, and Y2, connects a corresponding set of grounding switches 25 to a corresponding set of analog-to-digital converters 23. Specifically, each first connector 40 is simultaneously connected to the second connector 50 and a corresponding set of analog-to-digital converters 23 via a corresponding set of bidirectional switches 26. Taking four electrode sheets 10 as an example, the second cable 21 has eight conductors, including four conductors 1 to 4 that are electrically connected to the corresponding AC signal lines 28 one by one and used to transmit alternating current signals, one conductor 5 that is electrically connected to the data receiving line RX of the first communication unit 27, one conductor 6 that is electrically connected to the data transmitting line TX of the first communication unit 27, one conductor 7 that is electrically connected to the VCC power line of the first power module 29, and one conductor 8 that is electrically connected to the GND line of the first power module 29.

[0119] The second connector 50 is connected to the first communication unit 27 through the data receiving line RX and the data sending line TX. The VCC pin of the second connector 50 is connected to the VVC power line of the first power module 29. The GND pin of the second connector 50 is connected to the GND line of the first power module 29 and is grounded. The VCC pin of the second connector 50 is also connected to the corresponding group of voltage dividers 24 and the corresponding group of analog-to-digital converters 23 through the VCC power line of the first power module 29.

[0120] refer to Figure 5The electric field generator 30 includes a second power module 31, a second controller 32, an AC signal generator 34, a second communication unit 33, and a set of AC signal switches 35. The VCC pin of the second connector 50 is also electrically connected to the VCC power line of the second power module 31, and the GND pin of the second connector 50 is grounded through the GND line of the second power module 31. The second power module 31 is also connected to the second controller 32 and the AC signal generator 34 and supplies power to them. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 via its data receiving line RX and to the wire 6 of the second connector 50 via its data transmitting line TX, thereby enabling information exchange between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34, and the set of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in a group of AC signal switches 35 and adjust the relevant parameters of the AC signal applied by the AC signal generator 34 according to the relevant digital signal received from the adapter 20 by the second communication unit 33. The AC signal generator 34 is electrically connected to the wires 1 to 4 of the second connector 50 that transmit the AC signal through the group of AC signal switches 35. A group of AC signal switches 35 includes a plurality of AC signal switches 35, and the plurality of AC signal switches 35 are arranged in a one-to-one correspondence with the plurality of electrode sheets 10. Each AC signal switch 35 is electrically connected to a corresponding wire 1, 2, 3, 4 that transmits the AC signal in the second connector 50 through an AC signal connection 36 and is electrically connected to the corresponding electrode sheet 10 through the corresponding wire 1, 2, 3, 4 of the second connector 50, so as to transmit the AC signal to each electrode sheet 10. The AC signal generator 34 is electrically connected to the group of AC signal switches 35 through a group of AC signal connections 36.

[0121] Specifically, the number of AC signal switches 35 of the electric field generator 30 is related to the number of electrode sheets 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode sheets 10, and both are four. The AC signal switches 35 include a first AC signal switch 35-1, a second AC signal switch 35-2, a third AC signal switch 35-3, and a fourth AC signal switch 35-4, which are electrically connected to the wires 1 to 4 of the second connector 50 through corresponding AC signal wiring 36, respectively.One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 through the first AC signal connection 36-1 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 1 for transmitting AC signals in the second connector 50 through the first AC signal connection 36-1 and electrically connected to the AC signal line 28 at the port X1 of the adapter 20 through the conductor 1 of the second connector 50, the AC signal line 28 at the port X1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits an AC signal to the electrode sheet 10 electrically connected to the port X1 of the adapter 20; One end of the second AC signal switch 35-2 is electrically connected to the AC signal generator 34 through the second AC signal connection 36-2 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 2 for transmitting AC signals in the second connector 50 through a second AC signal connection 36-2 and electrically connected to the AC signal line 28 at the port Y1 of the adapter 20 through the wire 2 of the second connector 50, the AC signal line 28 at the port Y1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits the AC signal to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20; One end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 through the third AC signal connection 36-3 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 3 for transmitting AC signals in the second connector 50 through a third AC signal connection 36-3 and electrically connected to the AC signal line 28 at the port X2 of the adapter 20 through the wire 3 of the second connector 50, the AC signal line 28 at the port X2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits an AC signal to the electrode sheet 10 electrically connected to the port X2 of the adapter 20; One end of the fourth AC signal switch 35-4 is electrically connected to the AC signal generator 34 through the fourth AC signal connection 36-4 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 4 for transmitting AC signals in the second connector 50 through a fourth AC signal connection 36-4 and electrically connected to the AC signal line 28 at the port Y2 of the adapter 20 through the conductor 4 of the second connector 50, the AC signal line 28 at the port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20.

[0122] The following will refer toFigure 3 to Figure 5 The working principle of the tumor electric field treatment system 100 of this embodiment is described in detail.

[0123] Specifically, when it is necessary to detect the temperature of each electrode unit 12 of a certain electrode sheet 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the collection end 1 of each of the multiple bidirectional switching switches 26 of a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to be turned on and the input end 2 to be disconnected, so as to disconnect the AC signal applied to the electrode sheet 10; at the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 in a group of grounding switches 25 electrically connected to the electrode sheet 10 to be turned on in sequence. At this time, the temperature detection signals collected by each temperature sensor 14 of each electrode unit 12 of each row group of the electrode sheet 10 can be collected in sequence through multiple detection channels A, B, C, and D of a group of analog-to-digital converters 23 corresponding to the electrode sheet 10. Each detection channel A, B, C, and D of each group of analog-to-digital converters 23 simultaneously collects only the temperature detection signals of the temperature sensors 14 corresponding to the electrode units 12 of the electrode sheet 10 in the same row group. The temperature detection signals can be represented by voltage values, indicating that only one of the five grounding switches 25 in the group of grounding switches 25 corresponding to the electrode sheet 10 is turned on at the same time, while the other four are turned off. All four of the four bidirectional switching switches 26 in the group of bidirectional switching switches 26 corresponding to the group of analog-to-digital converters 23 are switched to their respective collection terminals 1 so that the dual-purpose signal lines 19 of the electrode sheet 10 are electrically connected to the corresponding detection channels A, B, C, and D of the corresponding group of analog-to-digital converters 23 in a one-to-one correspondence and are turned on. With this arrangement, the group of analog-to-digital converters 23 can collect the voltage values ​​of the temperature sensors 14 of the electrode units 12 in the same row group that are short-circuited with the grounding line 18 corresponding to the turned-on grounding switch 25.

[0124] Specifically, when the first grounding switch 25-1 is closed, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, and the fourth bidirectional switch 26-4 are all switched to their respective acquisition terminals 1, the temperature sensors 14 of the electrode units 12-1 to 12-4 of the first row group are powered on, and the temperature sensors 14 of the electrode units 12-5 to 12-20 of the remaining row groups are powered off, and the first detection channel A in the analog-to-digital converter 23 of the group short-circuits the respective electrode units 12-1, 12-5, 12-9, 12-13, and 12-17. As for the signal terminal 14-2 of the temperature sensor 14, since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-1 is connected to the ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-5, 12-9, 12-13, and 12-17 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the first row do not affect the resistance value of the temperature sensor 14 of electrode unit 12-1. Therefore, only the temperature sensor 14 of electrode unit 12-1 is effectively operating on the first detection channel A of the group of analog-to-digital converters 23. The temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-1. Similarly, the voltage value collected by the second detection channel B of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-2. The voltage value collected on the third detection channel C of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-3. The voltage value collected on the fourth detection channel D of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-4.

[0125] When the second grounding switch 25-2 is closed, the first grounding switch 25-1, the third grounding switch 25-3, the fourth grounding switch 25-4 and the fifth grounding switch 25-5 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3 and the fourth bidirectional switch 26-4 are all switched to their respective acquisition terminals 1, the temperature sensors 14 of the electrode units 12-5 to 12-8 of the second row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-4 and the electrode units 12-9 to 12-20 of the remaining row groups are powered off, and the first detection channel A in the analog-to-digital converter 23 of the group short-circuits the electrode units 12-1, 12-5, 12-9, 12-13 and 12-20. -17, only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-5 is connected to the ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-1, 12-9, 12-13, and 12-17 are all disconnected. Furthermore, each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14. The remaining temperature sensors 14 in the second row do not affect the resistance of the temperature sensor 14 of electrode unit 12-5. Therefore, only the temperature sensor 14 of electrode unit 12-5 is effectively operating on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-5. Similarly, the voltage value collected by the second detection channel B of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-6. The voltage value collected on the third detection channel C of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-7. The voltage value collected on the fourth detection channel D of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-8.

[0126] When the third grounding switch 25-3 is closed, the first grounding switch 25-1, the second grounding switch 25-2, the fourth grounding switch 25-4 and the fifth grounding switch 25-5 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3 and the fourth bidirectional switch 26-4 are all switched to the collection end 1, the temperature sensors 14 of the electrode units 12-9 to 12-12 in the third row group are powered on, the temperature sensors 14 of the electrode units 12-1 to 12-8 and 12-13 to 12-20 in the other row groups are powered off, the signal ends 14-2 of the temperature sensors 14 of the electrode units 12-1, 12-5, 12-9, 12-13 and 12-17 in the first detection channel A of the group of analog-to-digital converters 23 are short-circuited, only the ground end 14-1 of the temperature sensor 14 of the electrode unit 12-9 is connected to the ground, the ground ends 14-1 of the temperature sensors 14 of the electrode units 12-1, 12-5, 12-13 and 12-17 are all disconnected, and the diode 16 in series with the temperature sensor 14 is arranged on each electrode unit 12, so the resistance of the temperature sensor 14 of the electrode unit 12-9 is not affected by the other temperature sensors 14 in the third row, and only the temperature sensor 14 of the electrode unit 12-9 in the first detection channel A of the group of analog-to-digital converters 23 works effectively, so the voltage value collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-9. Similarly, the voltage value collected by the second detection channel B of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-10. The voltage value collected by the third detection channel C of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-11. The voltage value collected by the fourth detection channel D of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-12.

[0127] When the fourth grounding switch 25-4 is closed, the first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fifth grounding switch 25-5 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3 and the fourth bidirectional switch 26-4 are all switched to their respective acquisition terminals 1, the temperature sensors 14 of the electrode units 12-13 to 12-16 of the fourth row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-12 and the electrode units 12-17 to 12-20 of the remaining row groups are powered off, and the first detection channel A in the analog-to-digital converter 23 of the group short-circuits the electrode units 12-1, 12-5, 12-9, 12-13 and 12-20. -17, since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-13 is connected to the ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode unit 12-1, electrode unit 12-5, electrode unit 12-9, and electrode unit 12-17 are all disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the fourth row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-13. Therefore, only the temperature sensor 14 of electrode unit 12-13 is effectively operating on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-13. Similarly, the voltage value collected by the second detection channel B of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-14. The voltage value collected on the third detection channel C of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode units 12-15. The voltage value collected on the fourth detection channel D of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode units 12-16.

[0128] When the fifth grounding switch 25-5 is closed, the first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3 and the fourth bidirectional switch 26-4 are all switched to the collection end 1, the temperature sensor 14 of each electrode unit 12-17 to 12-20 in the fifth row group is powered on, and the temperature sensor 14 of each electrode unit 12-1 to 12-16 in the remaining row groups is powered off. The signal end 14-2 of the temperature sensor 14 of each electrode unit 12-1, 12-5, 12-9, 12-13 and 12-17 in the first detection channel A of the group of analog-to-digital converters 23 is short-circuited, because only the ground end 14-1 of the temperature sensor 14 of the electrode unit 12-17 is connected to the ground, and the ground end 14-1 of the temperature sensor 14 of each electrode unit 12-1, 12-5, 12-9 and 12-13 is disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14. The remaining temperature sensors 14 in the fifth row do not affect the resistance value of the temperature sensor 14 of the electrode unit 12-17, so only the temperature sensor 14 of the electrode unit 12-17 in the first detection channel A of the group of analog-to-digital converters 23 is effectively working. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-17. Similarly, the voltage value collected by the second detection channel B of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-18. The voltage value collected by the third detection channel C of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-19. The voltage value collected by the fourth detection channel D of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-20.

[0129] Therefore, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can control a group of bidirectional switches 26 and a group of grounding switches 25 connected to an electrode sheet 10 to collect the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the electrode sheet 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode sheets 10 can be obtained.

[0130] The first controller 22, the plurality of analog-to-digital converters 23, and the plurality of bidirectional switches 26 can automatically perform operations according to pre-programmed program codes. For example, the first controller 22 first controls all bidirectional switches 26 in the corresponding group of bidirectional switches 26 to switch to the acquisition terminal 1, so that the acquisition terminals 1 of the bidirectional switches 26 are all turned on and the input terminals 2 are all turned off, so that the dual-purpose signal lines 19 of the corresponding electrode sheets 10 are electrically connected to the corresponding group of analog-to-digital converters 23. Then, the first grounding switch 25-1 in the corresponding group of grounding switches 25 is closed, and the remaining second grounding switches 25-2, third grounding switches 25-3, fourth grounding switches 25-4, and fifth grounding switches 25-5 in the group of grounding switches 25 are turned off. During this period, Each detection channel A, B, C, and D of the set of analog-to-digital converters 23 acquires the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the first row group of the corresponding electrode sheet 10, converts them into digital signals, and stores them in a separately provided memory. Then, after a preset interval, the first controller 22 closes the second grounding switch 25-2 of the set of grounding switches 25 and opens the first grounding switch 25-1, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5 of the set of grounding switches 25. During this period, each detection channel A, B, C, and D of the set of analog-to-digital converters 23 acquires the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the second row group. By sequentially opening each grounding switch 25 in the set of grounding switches 25, the temperature detection signals of all temperature sensors 14 located in each row group of the electrode sheet 10 can be obtained. Similarly, through this operation, the temperature detection signals of all temperature sensors 14 on at least one pair of electrode sheets 10 are obtained.

[0131] The tumor electric field therapy system 100 of the present application can realize real-time and comprehensive monitoring of the temperature of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or adding the core of the first cable 13 electrically connected to the electrode sheet 10, and then determine whether the electrode sheet 10 is qualified based on the obtained temperature detection signal; or determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14 obtained; or if the electrode sheet is qualified, identify the type of electrode sheet based on the obtained temperature detection signal; or if the electrode sheet is qualified, determine whether the electrode unit 12 of the electrode sheet 10 is overheated based on the obtained temperature detection signal, and then control the alternating electric signal applied to the electrode sheet 10 or the electrode unit 12 of the corresponding column of the electrode sheet 10, so as to avoid low-temperature burns on the patient's body surface when tumor treatment is performed through the electrode sheet 10. In addition, the flexible circuit board 11 of the electrode sheet 10 of the present application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal terminal 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. While it can transmit both AC signals and DC signals for temperature signal acquisition and the collected temperature detection signals through the dual-purpose signal line 19, it also greatly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) arranged thereon, thereby reducing the wiring difficulty of the flexible circuit board 11, simplifying the manufacturing process, reducing the weight of the flexible circuit board 11, and reducing manufacturing costs. The electrode sheet 10 of the present application can also switch between applying AC signals for tumor treatment and transmitting DC signals for temperature acquisition and the collected temperature detection signals through the combined control of a grounding switch 25 electrically connected to the grounding line 18 arranged thereon and a bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19.

[0132] When it is necessary to apply an alternating current signal to the patient through the electrode units 12 of a certain electrode sheet 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all the grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10 to be disconnected, and at the same time controls all the bidirectional switching switches 26 in a group of bidirectional switching switches 26 corresponding to the electrode sheet 10 to be switched to their respective input ends 2, so that the collection ends 1 of the bidirectional switching switches 26 are all disconnected and the input ends 2 are all turned on, so that the dual-purpose signal lines 19 of the electrode sheet 10 are electrically connected to the adapter 20 and an AC signal line 28 corresponding to the electrode sheet 10, thereby transmitting the alternating current signal to the electrode units 12 of the electrode sheet 10.When the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of the electrode sheet 10 are much lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue to generate an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude, and then transmits it to the corresponding pair of electrode sheets 10 through a corresponding AC signal line 28 of the adapter 20, so that the pair of electrode sheets 10 continue to apply the AC signal; when the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of the electrode sheet 10 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue to generate an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude, and then transmits it to the corresponding pair of electrode sheets 10 through a corresponding AC signal line 28 of the adapter 20, so that the pair of electrode sheets 10 continue to apply the AC signal; The field generator 30 can reduce the voltage or current of the alternating current signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the alternating current signal applied to the pair of electrode sheets 10; when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 in a certain electrode sheet 10 is greater than a preset temperature threshold, the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to disconnect through the second controller 32 to stop applying the alternating current signal to the electrode sheet 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all the bidirectional switches in a group of bidirectional switches 26 electrically connected to the electrode sheet 10 26 are all switched from their input end 2 to the collection end 1, that is, the collection ends 1 of all the bidirectional switch 26 of a group of bidirectional switch 26 electrically connected to the electrode sheet 10 are all turned on and the input ends 2 are all disconnected, thereby stopping the application of the alternating electric signal to the electrode sheet 10; or, when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 of a certain electrode sheet 10 is greater than the preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to continue to be turned on, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a bidirectional switch electrically connected to the electrode unit 12 of the electrode sheet 10 to be turned on. The switch 26 switches from its input end 2 to its collection end 1, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 simultaneously controls the input ends 2 of the remaining bidirectional switches 26 electrically connected to the electrode units 12 of the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold and are in different columns from the electrode units 12 whose temperature detection signals exceed the preset temperature threshold to continue to maintain electrical connection, thereby stopping the application of the AC signal to all electrode units 12 in the column of the electrode unit 12 of the electrode sheet 10 whose temperature detection signals exceed the preset temperature threshold, and continuing to apply the AC signal to the electrode units 12 in the remaining columns of the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold. This implements the control method of the tumor electric field therapy system 100 for regional application of the AC signal based on the temperature detection signal.When an AC signal is applied, all grounding switches 25 are opened.

[0133] In the embodiment of the present application, the grounding switch 25 electrically connected to each of the multiple grounding lines 18 of the electrode sheet 10 and the bidirectional switch 26 electrically connected to each of the multiple dual-purpose signal lines 19 of the electrode sheet 10 are both provided in the adapter 20. However, in other embodiments, the grounding switch 25 electrically connected to the grounding line 18 and the bidirectional switch 26 electrically connected to the dual-purpose signal line 19 can also be provided on the electrode sheet 10 or provided in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 provided in the adapter 20 can also be provided in the electric field generator 30 and directly controlled by the second controller 32.

[0134] The present application also provides other embodiments of the electrode sheet 10 and the adapter 20. The differences between the multiple embodiments of the electrode sheet 10 are mainly the different numbers of electrode units 12 and / or the different electrical connection arrangements of the electrode units 12. The multiple embodiments of the adapter 20 are adapted to the electrode sheets 10 in different embodiments. The main difference is the different numbers of grounding switches 25 and bidirectional switching switches 26, which will be explained separately below.

[0135] refer to Figure 6As shown, the electrode sheet 10A of the second embodiment is provided with 19 electrode units 12, and the flexible circuit board 11A electrically connects the 19 electrode units 12 in four rows and five columns, in which four rows each have four electrode units 12, and the remaining one row has three electrode units 12. The electrode sheet 10A includes five ground lines 18 and four dual-purpose signal lines 19. Each ground line 18 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the electrode units 12 in the same row group. Each dual-purpose signal line 19 is used to short the signal terminals 14-2 of the dielectric elements 15 and the temperature sensors 14 of the electrode units 12 in each column group, for receiving temperature detection signals or transmitting alternating current signals. The five ground lines 18 of the electrode sheet 10A include a first ground line 18-1, a second ground line 18-2, a third ground line 18-3, a fourth ground line 18-4, and a fifth ground line 18-5. The first row group includes the electrode units 12-1 to 12-4, the second row group includes the electrode units 12-5 to 12-8, the third row group includes the electrode units 12-9 to 12-12, the fourth row group includes the electrode units 12-13 to 12-16, and the fifth row group includes the electrode units 12-17 to 12-19. Specifically, the first ground line 18-1 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the four electrode units 12-1 to 12-4 in the first row group, the second ground line 18-2 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the four electrode units 12-5 to 12-6 in the second row group, the third ground line 18-3 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the four electrode units 12-9 to 12-12 in the third row group, the fourth ground line 18-4 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the four electrode units 12-13 to 12-16 in the fourth row group, and the fifth ground line 18-5 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the three electrode units 12-17 to 12-19 in the fifth row group. In short, each ground line 18 grounds the ground terminals 14-1 of the temperature sensors 14 of all the electrode units 12 in each row group.

[0136] The four dual-purpose signal lines 19 of the electrode sheet 10A include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, and a fourth dual-purpose signal line 19-4. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the five electrode units 12, namely, electrode unit 12-1, electrode unit 12-5, electrode unit 12-9, electrode unit 12-13, and electrode unit 12-17, and the signal end 14-2 of the temperature sensor 14 of each of the five electrode units 12; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the five electrode units 12, namely, electrode unit 12-2, electrode unit 12-6, electrode unit 12-10, electrode unit 12-14, and electrode unit 12-18, and the signal end 14-2 of the temperature sensor 14 of each of the five electrode units 12. One end of a third dual-purpose signal line 19-3 is simultaneously connected to the dielectric elements 15 of each of the five electrode units 12 (electrode unit 12-3, electrode unit 12-7, electrode unit 12-11, electrode unit 12-15, and electrode unit 12-19), as well as the signal end 14-2 of each temperature sensor 14. One end of a fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric elements 15 of each of the four electrode units 12 (electrode unit 12-4, electrode unit 12-8, electrode unit 12-12, and electrode unit 12-16), as well as the signal end 14-2 of each temperature sensor 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 and the signal end 14-2 of each temperature sensor 14 of each electrode unit 12 in the same column group, and is then used to connect to the adapter 20.

[0137] The adapter 20 of the first embodiment is adaptable to the electrode sheet 10A of the second embodiment. The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5 of the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3, the fourth grounding line 18-4, and the fifth grounding line 18-5 of the electrode sheet 10A, respectively, via a first connector 40. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, and the fourth bidirectional switch 26-4 of the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, and the fourth dual-purpose signal line 19-4 of the electrode sheet 10A, respectively, via a first connector 40. The tumor electric field therapy system formed by the electrode sheet 10A, the adapter 20, and the electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. When all grounding switches 25 are disconnected and the input terminals 2 of all bidirectional switches 26 are connected and the acquisition terminals 1 are disconnected, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 are connected to the AC signal. When the acquisition terminals 1 of all bidirectional switches 26 are connected and the input terminals 2 are disconnected, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group are sequentially obtained by sequentially turning on each grounding switch 25.

[0138] refer to Figure 7As shown, the electrode sheet 10B of the third embodiment is provided with 18 electrode units 12. A flexible printed circuit board 11B electrically arranges these 18 electrode units 12 into three rows and six columns, with each row having six electrode units 12. The electrode sheet 10B includes three grounding wires 18 and six dual-purpose signal wires 19. Each grounding wire 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the same row group. Each dual-purpose signal wire 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in each column group, respectively, for receiving temperature detection signals or transmitting AC signals. The three grounding wires 18 of the electrode sheet 10B include a first grounding wire 18-1, a second grounding wire 18-2, and a third grounding wire 18-3. The first row group includes electrode units 12-1 to 12-6, the second row group includes electrode units 12-7 to 12-12, and the third row group includes electrode units 12-13 to 12-18. Specifically, first grounding line 18-1 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the six electrode units 12 in the first row group, electrode units 12-1 to 12-6. Second grounding line 18-2 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the six electrode units 12 in the second row group, electrode units 12-7 to 12-12. Third grounding line 18-3 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the six electrode units 12 in the third row group, electrode units 12-13 to 12-18. In short, each grounding line 18 short-circuits the ground terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group and grounds them.

[0139] The six dual-purpose signal lines 19 of the electrode sheet 10B include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, a fifth dual-purpose signal line 19-5, and a sixth dual-purpose signal line 19-6. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-1, the electrode unit 12-7, and the electrode unit 12-13, and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-8, and the electrode unit 12-14, and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-3, the electrode unit 12-9, and the electrode unit 12-15, and the signal end 14- 2; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-4, electrode unit 12-10, and electrode unit 12-16), as well as the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12; one end of the fifth dual-purpose signal line 19-5 is simultaneously connected to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-5, electrode unit 12-11, and electrode unit 12-17), as well as the signal end 14-2 of the temperature sensor 14; one end of the sixth dual-purpose signal line 19-6 is simultaneously connected to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-6, electrode unit 12-12, and electrode unit 12-18), as well as the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 of each electrode unit 12 and the signal end 14-2 of each temperature sensor 14 in the corresponding column group, and is used to connect to the adapter 20A.

[0140] Combine Figure 9As shown, the adapter 20A of the second embodiment is adapted to the electrode sheet 10B of the third embodiment, and the adapter 20A is provided with three ground switches 25 (a first ground switch 25-1, a second ground switch 25-2, and a third ground switch 25-3) and six bidirectional switches 26 (a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, a fifth bidirectional switch 26-5, and a sixth bidirectional switch 26-6). The first ground switch 25-1, the second ground switch 25-2, and the third ground switch 25-3 are respectively electrically connected to the first ground line 18-1, the second ground line 18-2, and the third ground line 18-3 of the electrode sheet 10B through the first connector 40A of the second embodiment. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, the fifth bidirectional switch 26-5, and the sixth bidirectional switch 26-6 on the adapter 20A are respectively electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, the fifth dual-purpose signal line 19-5, and the sixth dual-purpose signal line 19-6 of the electrode sheet 10B through the first connector 40A. The working mode of the tumor electric field treatment system formed by the electrode sheet 10B, the adapter 20A, and the electric field generator 30 is the same as that of the tumor electric field treatment system 100 described above. When all the ground switches 25 are disconnected and the input end 2 of all the bidirectional switches 26 is turned on and the collection end 1 is disconnected, all the dual-purpose signal lines 19 are connected to the AC signal line 28, and all the electrode units 12 are connected to the AC signal; when the collection end 1 of all the bidirectional switches 26 is turned on and the input end 2 is disconnected, the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of each row group can be obtained in turn by sequentially turning on each ground switch 25.

[0141] Reference Figure 8As shown, the electrode sheet 10C of the fourth embodiment has 17 electrode units 12. Electrically, a flexible printed circuit board 11C arranges these 17 electrode units 12 into three rows and six columns. Two rows each have six electrode units 12, and the remaining row has five electrode units 12. The electrode sheet 10C includes three grounding lines 18 and six dual-purpose signal lines 19. Each grounding line 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the same row group. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in the same column group, respectively, for receiving temperature detection signals or transmitting AC signals. The three grounding lines 18 of the electrode sheet 10C include a first grounding line 18-1, a second grounding line 18-2, and a third grounding line 18-3. The first row group includes electrode units 12-1 to 12-6, the second row group includes electrode units 12-7 to 12-12, and the third row group includes electrode units 12-13 to 12-18. Specifically, first grounding line 18-1 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the six electrode units 12 in the first row group, namely electrode units 12-1 to 12-6. Second grounding line 18-2 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the six electrode units 12 in the second row group, namely electrode units 12-7 to 12-12. Third grounding line 18-3 is used to ground the ground terminals 14-1 of the temperature sensors 14 of the five electrode units 12 in the third row group, namely electrode units 12-13 to 12-17. In short, each grounding line 18 short-circuits the ground terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group and grounds them.

[0142] The six dual-purpose signal lines 19 of the electrode sheet 10C include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, a fifth dual-purpose signal line 19-5, and a sixth dual-purpose signal line 19-6. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-1, the electrode unit 12-7, and the electrode unit 12-13, and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-8, and the electrode unit 12-14, and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-3, the electrode unit 12-9, and the electrode unit 12-15, and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12 One end of the fourth dual-purpose signal line 19-4 is connected simultaneously to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-4, electrode unit 12-10, and electrode unit 12-16), as well as the signal end 14-2 of the temperature sensor 14. One end of the fifth dual-purpose signal line 19-5 is connected simultaneously to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-5, electrode unit 12-11, and electrode unit 12-17), as well as the signal end 14-2 of the temperature sensor 14. One end of the sixth dual-purpose signal line 19-6 is connected simultaneously to the dielectric elements 15 of the two electrode units 12 (electrode unit 12-6 and electrode unit 12-12), as well as the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 of each electrode unit 12 and the signal end 14-2 of each temperature sensor 14 in the same column group, and is used to connect to the adapter 20A.

[0143] refer to Figure 9The adapter 20A of the second embodiment can be adapted to the electrode sheet 10C of the fourth embodiment. The first ground switch 25-1, the second ground switch 25-2 and the third ground switch 25-3 of the adapter 20A are electrically connected to the first ground line 18-1, the second ground line 18-2 and the third ground line 18-3 of the electrode sheet 10C respectively through the first connector 40A. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, the fifth bidirectional switch 26-5 and the sixth bidirectional switch 26-6 of the adapter 20A are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, the fifth dual-purpose signal line 19-5 and the sixth dual-purpose signal line 19-6 of the electrode sheet 10C respectively through the first connector 40A. The working mode of the tumor electric field therapy system formed by the electrode sheet 10C, the adapter 20A and the electric field generator 30 is the same as that of the tumor electric field therapy system 100. When the input end 2 of all the bidirectional switches 26 is turned on and the collection end 1 is turned off, all the dual-purpose signal lines 19 are turned on and the AC signal line 28 is turned on, and all the electrode units 12 are connected to the AC signal. When the collection end 1 of all the bidirectional switches 26 is turned on and the input end 2 is turned off, the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of each row group can be obtained in turn by turning on the ground switch 25 in turn.

[0144] Reference Figure 10 The tumor electric field therapy system 100D of the fifth embodiment of the present application is different from the tumor electric field therapy system 100 described in the Figure 1 The tumor electric field therapy system 100D of the fifth embodiment of the present application is different from the tumor electric field therapy system 100 described in the The electrode sheet 10D of the present embodiment also has four electrode units 12D arranged in axial symmetry and arranged in central symmetry, a plurality of connecting portions 111D between adjacent electrode units 12, and a wiring portion 112D electrically connected to the first cable 13D. The wiring portion 112D is arranged outward from an electrode unit 12 and perpendicular to a connecting portion 111D. The first cable 13D has 8 cores.

[0145] The electrode units 12D of the electrode sheet 10D have the same structure as the electrode units 12 in the aforementioned embodiment, the only difference being that the number of electrode units 12 in this embodiment is 13, and they are spatially arranged in five rows and five columns. Specifically, the first and last rows each have two electrode units 12, located in the second and fourth columns, respectively; each of the three middle rows has three electrode units 12, and the three electrode units 12 in each row are located in the first, third, and fifth columns, respectively. There are three electrode units 12 located in the center of the electrode array (unnumbered), namely, the three electrode units 12 located in the second row and third column, the third row and third column, and the third row and third column. The rest are electrode units 12 located on the periphery of the electrode array (unnumbered). Adjacent electrode units 12 in the periphery are connected by connecting portions 111D. The electrode units 12 in the second row and third column are connected to the electrode units 12 in the first and second rows and adjacent thereto via connecting portions 111D. The electrode units 12 in the fourth row and third column are connected to the electrode units 12 in the fourth and fifth rows and adjacent thereto via connecting portions 111D. The electrode units 12 in the third row and third column are also connected to the electrode units 12 adjacent thereto in the row and column directions via connecting portions 111D. The electrode units 12 in the periphery are connected in pairs via connecting portions 111D to form an octagonal ring structure.

[0146] Figure 11(A) Figure 10 A modified embodiment of the electrode sheet 10D is shown in FIG. 1 , wherein the electrode unit 12D′ of the electrode sheet 10D′ in this embodiment is Figure 10The electrode units 12D of the electrode sheet 10D shown in the figure are identical in spatial arrangement, and the connection portion 111D' connected to the electrode unit 12D' located in the center is also identical. The only difference is that: in the electrode sheet 10D' of this modified embodiment, two adjacent electrode units 12D' located partially on the periphery are connected by the connection portion 111D'; and two adjacent electrode units 12D' located partially on the periphery are disconnected and no connection portion 111D' is provided. Specifically, the two electrode units 12D' located in the first row are disconnected, the two electrode units 12D' located in the last row are disconnected, the two electrode units 12D' located in the first column of the second row and the two electrode units 12D' located in the second column of the first row are disconnected, the two electrode units 12D' located in the first column of the third row and the two electrode units 12D' located in the first column of the fourth row are disconnected, the two electrode units 12D' located in the fifth column of the second row and the two electrode units 12D' located in the fifth column of the third row are disconnected, and the two electrode units 12D' located in the fifth column of the fourth row and the two electrode units 12D' located in the fifth column of the fifth row are disconnected. A first gap D1' is formed between two electrode units 12D' located in adjacent columns and arranged in a disconnected manner, and a second gap D2' is formed between two electrode units 12D' located in adjacent rows and arranged in a disconnected manner. The provision of the first gap D1' and the second gap D2' prevents wrinkles in the electrode sheet 10D' during application, which could affect the overall adhesion of the electrode sheet.

[0147] FIG11(B) is similar to FIG11(B), which is also Figure 10 A modified embodiment of the electrode sheet 10D is shown in FIG. 1 , wherein the electrode unit 12D″ of the electrode sheet 10D″ is Figure 10 The electrode units 12D of the electrode sheet 10D shown in the figure are identical in spatial arrangement, with the only difference being that: in the electrode sheet 10D" in this variant embodiment, the two electrode units 12D" in the first row are arranged in a disconnected state, the two electrode units 12D" in the last row are arranged in a disconnected state, the two electrode units 12D" in the second row and first column and the two electrode units 12D" in the second row and third column are arranged in a disconnected state, and the two electrode units 12D' in the fourth row and third column and the two electrode units 12D' in the fourth row and fifth column are arranged in a disconnected state.

[0148] Figure 12 For use Figure 10 The electrode sheet 10D of the fifth embodiment of the tumor electric field treatment system 100D or its alternative embodiments 10D', 10D" is shown in FIG. Figure 1, which is a schematic diagram of the circuit connection of the adapter 20 of the first embodiment. The following describes the circuit by taking the electrode sheet 10D in the fifth embodiment as an example. In terms of electrical connection, the flexible circuit board 11D of the electrode sheet 10D arranges the 13 electrode units 12 into three rows and five columns, wherein two rows each have five electrode units 12, and the remaining row has three electrode units 12. The electrode sheet 10D includes three grounding wires 18 and five dual-purpose signal wires 19, each of which is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the same row group, and each dual-purpose signal wire 19 short-circuits the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, respectively, for receiving temperature detection signals or transmitting AC signals.

[0149] The three grounding wires 18 of the electrode sheet 10D are respectively a first grounding wire 18-1, a second grounding wire 18-2, and a third grounding wire 18-3. Of the three row groups of the electrode sheet 10D, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, and the third row group includes electrode units 12-11 to 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-5 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-6 to 12-10 in the second row group; and the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-11 to 12-13 in the third row group. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in the corresponding row group and connects them to ground.

[0150] The five dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-1, the electrode unit 12-6, and the electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-7, and the electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the electrode unit 12-3, the electrode unit 12-6, and the electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each The fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12 (electrode units 12-8 and 12-13) and the signal terminals 14-2 of the temperature sensors 14. One end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the two electrode units 12 (electrode units 12-4 and 12-9) and the signal terminals 14-2 of the temperature sensors 14. One end of the fifth dual-purpose signal line 19-5 is connected to the dielectric elements 15 of the two electrode units 12 (electrode units 12-5 and 12-10) and the signal terminals 14-2 of the temperature sensors 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 and the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12 in the same column group and connects them to the adapter 20B.

[0151] Combine Figure 14The electrode sheet 10D of the fifth embodiment is adapted to the adapter 20B of the third embodiment. The adapter 20B is equipped with three grounding switches 25 (a first grounding switch 25-1, a second grounding switch 25-2, and a third grounding switch 25-3) and six bidirectional switches 26 (a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, and a fifth bidirectional switch 26-5). The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20B are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode sheet 10D, respectively, via a first connector 40B. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4 and the fifth bidirectional switch 26-5 on the adapter 20B are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4 and the fifth dual-purpose signal line 19-5 of the electrode sheet 10D through the first connector 40B. The tumor electric field therapy system formed by the electrode sheet 10D, the adapter 20B, and the electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. When the input terminal 2 of all bidirectional switches 26 is turned on and the acquisition terminal 1 is turned off, all dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all electrode units 12 are connected to the AC signal. When all grounding switches 25 are turned off and the acquisition terminal 1 of all bidirectional switches 26 is turned on and the input terminal 2 is turned off, the temperature detection signal of the temperature sensor 14 of each electrode unit 12 in each row group can be obtained in sequence by turning on each grounding switch 25.

[0152] refer to Figure 13As shown, the electrode sheet 10E of the sixth embodiment has 13 electrode units 12, similar to the electrode sheet 10D of the fifth embodiment, but the specific circuit layout is different. The flexible circuit board 11E of the electrode sheet 10E also electrically arranges these 13 electrode units 12 into three rows and five columns, except that two rows each have four electrode units 12, and the remaining row has five electrode units 12. The electrode sheet 10E also includes three grounding lines 18 and five dual-purpose signal lines 19. Each grounding line 18 is used to ground the ground terminal 14-1 of each temperature sensor 14 in the same row group. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in the same column group, respectively, for receiving temperature detection signals or transmitting AC signals. The three grounding lines 18 of the electrode sheet 10E include a first grounding line 18-1, a second grounding line 18-2, and a third grounding line 18-3. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode units 12-9 to 12-13. Specifically, first grounding line 18-1 is used to ground the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-1 to 12-4 in the first row group; second grounding line 18-2 is used to ground the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-5 to 12-8 in the second row group; and third grounding line 18-3 is used to ground the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-9 to 12-13 in the third row group. In short, each grounding line 18 short-circuits the ground terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group and grounds them.

[0153] The five dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-1, the electrode unit 12-5, and the electrode unit 12-9, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-2, the electrode unit 12-6, and the electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the electrode unit 1 The first embodiment of the present invention relates to a dual-purpose signal line 19, which connects the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-3, electrode unit 12-7, and electrode unit 12-11) and the signal terminal 14-2 of each temperature sensor 14. A fourth dual-purpose signal line 19-4 connects one end of each of the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-4, electrode unit 12-8, and electrode unit 12-12) and the signal terminal 14-2 of each temperature sensor 14. A fifth dual-purpose signal line 19-5 connects one end of each of the dielectric element 15 of electrode unit 12-13 and the signal terminal 14-2 of its temperature sensor 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric element 15 and the signal terminal 14-2 of each temperature sensor 14 of each electrode unit 12 in the same column group and connects them to adapter 20B.

[0154] Combine Figure 14 The adapter 20B of the third embodiment is compatible with the electrode sheet 10E of the sixth embodiment. The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20B are electrically connected to the first grounding line 18-1, the second grounding line 18-2, and the third grounding line 18-3 of the electrode sheet 10E, respectively, via the first connector 40B. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20B are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode sheet 10E, respectively, via the first connector 40B.

[0155] The working mode of the tumor electric field treatment system formed by the electrode sheet 10E, the adapter 20B and the electric field generator 30 is the same as that of the tumor electric field treatment system 100 described above. When all the grounding switches 25 are disconnected and the input ends 2 of all the bidirectional switches 26 are turned on and the collection ends 1 are disconnected, all the dual-purpose signal lines 19 and the AC signal lines 28 are turned on, and all the electrode units 12 are connected to the AC signal. When the collection ends 1 of all the bidirectional switches 26 are turned on and the input ends 2 are disconnected, the temperature detection signals of the temperature sensors 14 of the electrode units 12 in each row group can be obtained in turn by sequentially turning on the grounding switches 25.

[0156] Reference Figure 15 As shown in FIG. 7, the electrode sheet 10F of the seventh embodiment has 13 electrode units 12, like the electrode sheet 10D of the sixth embodiment, but the specific circuit arrangement is different. The flexible circuit board 11F of the electrode sheet 10F electrically connects the 13 electrode units 12 into four rows and four columns, in which three rows each have four electrode units 12, and the remaining one row has one electrode unit 12. The electrode sheet 10F includes four grounding lines 18 and four dual-purpose signal lines 19. Each grounding line 18 is used to ground the ground ends 14-1 of the temperature sensors 14 of the electrode units 12 in the same row group. Each dual-purpose signal line 19 is used to short the dielectric elements 15 and the signal ends 14-2 of the temperature sensors 14 of the electrode units 12 in the corresponding column group, for receiving the temperature detection signals or transmitting the AC signals. The four grounding lines 18 of the electrode sheet 10F include a first grounding line 18-1, a second grounding line 18-2, a third grounding line 18-3 and a fourth grounding line 18-4. The first row group includes the electrode units 12-1 to 12-4, the second row group includes the electrode units 12-5 to 12-8, the third row group includes the electrode units 12-9 to 12-12, and the fourth row group includes the electrode unit 12-13. Specifically, the first grounding line 18-1 is used to ground the ground ends 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-4 in the first row group, the second grounding line 18-2 is used to ground the ground ends 14-1 of the temperature sensors 14 of the electrode units 12-5 to 12-8 in the second row group, the third grounding line 18-3 is used to ground the ground ends 14-1 of the temperature sensors 14 of the electrode units 12-9 to 12-12 in the third row group, and the fourth grounding line 18-4 is used to ground the ground end 14-1 of the temperature sensor 14 of the electrode unit 12-13 in the fourth row group. In short, each grounding line 18 shorts and grounds the ground ends 14-1 of the temperature sensors 14 of all the electrode units 12 in the corresponding row group.

[0157] The four dual-purpose signal lines 19 of the electrode sheet 10F include a first dual-purpose signal line 19 - 1 , a second dual-purpose signal line 19 - 2 , a third dual-purpose signal line 19 - 3 , and a fourth dual-purpose signal line 19 - 4 . One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-5, electrode unit 12-9, and electrode unit 12-13, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-2, electrode unit 12-6, and electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-3, electrode unit 12-7, and electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-4, electrode unit 12-8, and electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14 of each. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 and the signal terminals 14 - 2 of the temperature sensors 14 of the electrode units 12 in the same column group in parallel and is used to connect to the adapter 20C.

[0158] Combine Figure 17 The adapter 20C of the fourth embodiment is adapted for the electrode sheet 10F. The adapter 20C is equipped with four grounding switches 25 (a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, and a fourth grounding switch 25-4) and four bidirectional switches 26 (a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, and a fourth bidirectional switch 26-4). The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4 of the adapter 20C are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3, and the fourth grounding wire 18-4 of the electrode sheet 10F in the third embodiment through a first connector 40C. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3 and the fourth bidirectional switch 26-4 on the adapter 20C are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3 and the fourth dual-purpose signal line 19-4 respectively through the first connector 40C.

[0159] The tumor electric field therapy system formed by the electrode sheet 10F, the adapter 20C, and the electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. When all grounding switches 25 are disconnected and the input terminals 2 of all bidirectional switches 26 are connected and the acquisition terminals 1 are disconnected, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 are connected to the AC signal. When the acquisition terminals 1 of all bidirectional switches 26 are connected and the input terminals 2 are disconnected, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group are sequentially obtained by sequentially turning on each grounding switch 25.

[0160] refer to Figure 16 As shown, the electrode sheet 10G of the eighth embodiment also has 13 electrode units 12, but the specific circuit layout is different. The flexible circuit board 11G of the electrode sheet 10G electrically arranges these 13 electrode units 12 into four rows and four columns. Three rows each have three electrode units 12, and the remaining row has four electrode units 12. The electrode sheet 10G includes four grounding lines 18 and four dual-purpose signal lines 19. Each grounding line 18 is used to ground the ground terminal 14-1 of each temperature sensor 14 in the same row group. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in a corresponding column group, respectively, for receiving temperature detection signals or transmitting AC signals. The four grounding lines 18 of the electrode sheet 10G include a first grounding line 18-1, a second grounding line 18-2, a third grounding line 18-3, and a fourth grounding line 18-4. The first row group includes electrode units 12-1 to 12-3, the second row group includes electrode units 12-4 to 12-6, the third row group includes electrode units 12-7 to 12-9, and the fourth row group includes electrode units 12-10 to 12-13. Specifically, first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1 to 12-3 in the first row group, second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-4 to 12-6 in the second row group, third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-7 to 12-9 in the third row group, and fourth grounding wire 18-4 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-10 to 12-13 in the fourth row group. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in the corresponding row group and connects them to ground.

[0161] The four dual-purpose signal lines 19 of the electrode sheet 10G include a first dual-purpose signal line 19 - 1 , a second dual-purpose signal line 19 - 2 , a third dual-purpose signal line 19 - 3 , and a fourth dual-purpose signal line 19 - 4 . One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-4, electrode unit 12-7, and electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14 of each of them; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-2, electrode unit 12-5, electrode unit 12-8, and electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each of them; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-3, electrode unit 12-6, electrode unit 12-9, and electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14 of each of them; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric element 15 of electrode unit 12-13 and the signal end 14-2 of its temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 and the signal terminals 14 - 2 of the temperature sensors 14 of the electrode units 12 in the same column group in parallel and is used to connect to the adapter 20C.

[0162] refer to Figure 17 The adapter 20C is adapted for the electrode sheet 10G. The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4 on the adapter 20C are electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3, and the fourth grounding line 18-4 of the electrode sheet 10G, respectively, via the first connector 40C. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, and the fourth bidirectional switch 26-4 on the adapter 20C are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, and the fourth dual-purpose signal line 19-4, respectively, via the first connector 40C.

[0163] The tumor electric field therapy system formed by the electrode sheet 10G, the adapter 20C, and the electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. When all grounding switches 25 are disconnected and the input terminals 2 of all bidirectional switches 26 are connected and the acquisition terminals 1 are disconnected, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 are connected to the AC signal. When the acquisition terminals 1 of all bidirectional switches 26 are connected and the input terminals 2 are disconnected, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group are sequentially obtained by sequentially turning on each grounding switch 25.

[0164] refer to Figure 18 and Figure 19 As shown, the present application also provides another tumor treatment system 100H. The main difference between tumor treatment system 100H and the previous tumor treatment system 100 lies in the electrode sheet. The electrode sheet 10H of the ninth embodiment is provided with nine electrode units 12. Spatially, the nine electrode units 12 are arranged in an array of three rows and three columns. Electrically, the flexible circuit board 11H of electrode sheet 10H arranges these nine electrode units 12 in two rows and five columns, with one row having five electrode units 12 and the other row having four electrode units 12. Electrode sheet 10H includes two grounding wires 18 and five dual-purpose signal wires 19. Each grounding wire 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the same row group. Each dual-purpose signal wire 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in each column group, respectively, for receiving temperature detection signals or transmitting AC signals. The two grounding wires 18 of the electrode sheet 10H are respectively a first grounding wire 18-1 and a second grounding wire 18-2. In the two row groups of the electrode sheet 10H, the first row group includes electrode units 12-1 to 12-5, and the second row group includes electrode units 12-6 to 12-9. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-5 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-6 to 12-9 in the second row group. In short, each grounding wire 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group and grounds them.

[0165] The five dual-purpose signal lines 19 of the electrode sheet 10H include a first dual-purpose signal line 19 - 1 , a second dual-purpose signal line 19 - 2 , a third dual-purpose signal line 19 - 3 , a fourth dual-purpose signal line 19 - 4 , and a fifth dual-purpose signal line 19 - 5 . One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-1 and electrode unit 12-6, and the signal end 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-2 and electrode unit 12-7, and the signal end 14-2 of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-3 and electrode unit 12-8, and the signal end 14-2 of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-4 and electrode unit 12-9, and the signal end 14-2 of their respective temperature sensors 14; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of electrode unit 12-5 and the signal end 14-2 of its temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 and the signal terminals 14 - 2 of the temperature sensors 14 of the electrode units 12 in the same column group in parallel and is used to connect to the adapter 20D.

[0166] refer to Figure 20 The electrode sheet 10H is adapted to use the adapter 20D of the fifth embodiment. The adapter 20D is equipped with two grounding switches 25 (a first grounding switch 25-1 and a second grounding switch 25-2) and five bidirectional switches 26 (a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, and a fifth bidirectional switch 26-5). The first grounding switch 25-1 and the second grounding switch 25-2 on the adapter 20D are electrically connected to the first grounding wire 18-1 and the second grounding wire 18-2 of the electrode sheet 10H, respectively, via the first connector 40D of the fifth embodiment. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4 and the fifth bidirectional switch 26-5 of the adapter 20D are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4 and the fifth dual-purpose signal line 19-5 respectively through the first connector 40D.

[0167] The tumor electric field therapy system formed by the electrode sheet 10H, adapter 20D, and electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. When all grounding switches 25 are disconnected and the input terminals 2 of all bidirectional switches 26 are connected and the acquisition terminals 1 are disconnected, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 are connected to the AC signal. When the acquisition terminals 1 of all bidirectional switches 26 are connected and the input terminals 2 are disconnected, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group are sequentially obtained by sequentially turning on each grounding switch 25.

[0168] refer to Figure 21 As shown, the electrode sheet 10J of the tenth embodiment also has nine electrode units 12. Electrically, the flexible printed circuit board 11J of the electrode sheet 10J arranges these nine electrode units 12 into three rows and three columns, with each row having three electrode units 12. The electrode sheet 10J includes three grounding wires 18 and three dual-purpose signal wires 19. Each grounding wire 18 is used to ground the ground terminals 14-1 of the temperature sensors 14 corresponding to each electrode unit 12 in a row. Each dual-purpose signal wire 19 short-circuits the dielectric elements 15 of each electrode unit 12 and the signal terminals 14-2 of each temperature sensor 14 in a column, respectively, for receiving temperature detection signals or transmitting AC signals. The three grounding wires 18 of the electrode sheet 10J are a first grounding wire 18-1, a second grounding wire 18-2, and a third grounding wire 18-3. Of the three row groups of electrode sheet 10J, the first row group includes electrode units 12-1 through 12-3, the second row group includes electrode units 12-4 through 12-6, and the third row group includes electrode units 12-7 through 12-9. Specifically, first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1 through 12-3 in the first row group, second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-4 through 12-5 in the second row group, and third grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-7 through 12-9 in the third row group. In short, each grounding wire 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group and grounds them.

[0169] The three dual-purpose signal lines 19 of the electrode sheet 10J include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, and a third dual-purpose signal line 19-3. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-1, electrode unit 12-4, and electrode unit 12-7) and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12. One end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-2, electrode unit 12-5, and electrode unit 12-8) and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12. One end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric elements 15 of the three electrode units 12 (electrode unit 12-3, electrode unit 12-6, and electrode unit 12-9) and the signal end 14-2 of the temperature sensor 14 of each of the three electrode units 12. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 and the signal terminals 14 - 2 of the temperature sensors 14 of the electrode units 12 in the same column group in parallel and is used to connect to the adapter 20E.

[0170] refer to Figure 22 The adapter 20E of the sixth embodiment is adapted for use with the electrode sheet 10J. The adapter 20E is equipped with three grounding switches 25 (a first grounding switch 25-1, a second grounding switch 25-2, and a third grounding switch 25-3) and three bidirectional switches 26 (a first bidirectional switch 26-1, a second bidirectional switch 26-2, and a third bidirectional switch 26-3). The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 are electrically connected to the first grounding line 18-1, the second grounding line 18-2, and the third grounding line 18-3, respectively, via the first connector 40E of the sixth embodiment. The first bidirectional switch 26-1, the second bidirectional switch 26-2, and the third bidirectional switch 26-3 of the adapter 20E are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, and the third dual-purpose signal line 19-3, respectively, via the first connector 40E.

[0171] The tumor electric field therapy system formed by the electrode sheet 10J, the adapter 20E, and the electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. When the input terminal 2 of all bidirectional switches 26 is turned on and the acquisition terminal 1 is turned off, all dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all electrode units 12 are connected to the AC signal. When the acquisition terminal 1 of all bidirectional switches 26 is turned on and the input terminal 2 is turned off, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group are sequentially obtained by turning on each grounding switch 25 in sequence.

[0172] In the tumor electric field therapy system of the present application, the flexible circuit boards (11, 11A, 11B, 11C, 11D, 10D', 10D", 11E, 11F, 11G, 11H, 11J) of each electrode sheet (10, 10A, 10B, 10C, 10D, 10D', 10D", 10E, 10F, 10G, 10H, 10J) are electrically connected to divide the electrode units 12 into multiple rows and columns, and the ground terminals 14-1 of the temperature sensors 14 of the electrode units 12 in the same row are electrically connected to the same ground line 18, and the dielectric elements 15 and the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12 in the same column are short-circuited and connected to the same dual-purpose signal line. The adapter 20 is provided with a plurality of grounding switches 25 and a plurality of bidirectional switches 26. The grounding wires 18 of the electrode sheets (10, 10A, 10B, 10C, 10D, 10D', 10D", 10E, 10F, 10G, 10H, 10J) are electrically connected to the corresponding grounding switches 25, and the dual-purpose signal lines 19 are electrically connected to the corresponding bidirectional switches 26. The number of grounding switches 25 is equal to the number of grounding wires 18, and the number of bidirectional switches 26 is equal to the number of dual-purpose signal lines 19. Selecting an appropriate adapter for the corresponding electrode sheet avoids idle grounding switches 25 and / or bidirectional switches 26, thereby facilitating circuit control.

[0173] The present application also provides some temperature detection methods and AC signal application control methods, which are described below using the electrode sheet 10 as an example.

[0174] The present application embodiment provides an electrode sheet temperature detection method, which is applied to the above-mentioned electrode sheet 10 or tumor electric field treatment system 100. Figure 23 As shown, it includes the following steps:

[0175] Step 210: Control each bidirectional switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 and simultaneously connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10;

[0176] Step 220 : Turn on the grounding switches 25 electrically connected to the grounding terminals 14 - 1 of the temperature sensors 14 of the electrode units 12 of the electrode sheet 10 in sequence to obtain temperature detection signals from the temperature sensors 14 of the electrode units 12 of the electrode sheet 10 .

[0177] Step 210 is specifically as follows: controlling the bidirectional switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from the end electrically connected to the AC signal to the end electrically connected to the DC signal, that is, controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch from its input end 2 to its collection end 1; or

[0178] The bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 is controlled to switch the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 from the on state to the off state, and at the same time, the signal end 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 is switched from the off state to the on state.

[0179] The electrode sheet temperature detection method of the present application can quickly and accurately obtain the temperature of all electrode units of the electrode sheet; and based on the obtained temperature detection signals of all temperature sensors of the electrode sheet, it can be judged whether the temperature sensors of the electrode sheet are faulty, whether there is an abnormality, whether the electrode sheet is qualified, and whether it needs to be replaced; it can also be judged whether each electrode unit of the electrode sheet is overheated based on the obtained temperature detection signals of all temperature sensors of the electrode sheet when each temperature sensor of the electrode sheet is normal, and then control the AC signal applied to the electrode sheet or applied to each electrode unit of the electrode sheet; it can also be used to identify the type of electrode sheet when there is no abnormality in the temperature detection signals of each temperature sensor of the electrode sheet.

[0180] Ginseng Figure 24 As shown, the embodiment of the present application further provides a method for controlling application of an AC signal for tumor electric field therapy, which includes the above steps 210 and 220, and after step 220, further includes:

[0181] Step 260 : When it is determined that the electrode sheet 10 does not need to be replaced, the AC signal applied to each electrode unit 12 of the electrode sheet 10 is controlled or adjusted according to the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 .

[0182] Controlling or adjusting the AC signal applied to each electrode unit 12 of the electrode sheet 10 in step 260 also includes:

[0183] Step 261: When the temperature detection signals of the electrode units 12 of the electrode sheet 10 obtained do not exceed the preset temperature threshold, continue to apply the AC signal to the electrode units 12 of the electrode sheet 10; or

[0184] Step 262 : When a temperature detection signal among the acquired temperature detection signals of all the electrode units 12 of the electrode sheet 10 exceeds a preset temperature threshold, stop applying the AC signal to the electrode units 12 of the electrode sheet 10 .

[0185] The stopping of applying the AC signal to the electrode unit 12 of the electrode sheet 10 described in step 262 includes stopping applying the AC signal to all electrode units 12 of the electrode sheet 10, stopping applying the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold, and stopping applying the AC signal to all electrode units 12 in the column where the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is located.

[0186] When the application of the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is stopped, the AC signal continues to be applied to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal does not exceed the preset temperature threshold.

[0187] When the application of the AC signal to all electrode units 12 in the column where the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold in the electrode sheet 10 is located is stopped, the AC signal continues to be applied to all electrode units 12 in the electrode sheet 10 where the temperature detection signal does not exceed the preset temperature threshold and is in a different column from the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold.

[0188] The process of continuing to apply the AC signal to the electrode sheet 10 in step 261 is specifically as follows:

[0189] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 or continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged; or

[0190] Step 264: When the temperature detection signal approaches a preset temperature threshold, continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that keeps the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged, or continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that reduces the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10.

[0191] Ginseng Figure 25 As shown, the present application also provides a signal control method for tumor electric field therapy, which is used for the above-mentioned electrode sheet 10, and the method includes:

[0192] Step 310: Combine and control the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10 and execute step 320;

[0193] Step 320: Combine and control the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to collect temperature detection signals of each electrode unit of the electrode sheet 10 in a row and execute step 330;

[0194] Step 330: Determine the combined control mode of the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signal and execute step 340;

[0195] Step 340 : Control the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combined control mode of the grounding switch 25 and the bidirectional switch 26 .

[0196] The operating states of the electrode units 12 of the electrode sheet 10 described in step 340 include: stopping applying the AC signal and continuing to collect the temperature detection signal, and stopping collecting the temperature detection signal and continuing to apply the AC signal. Continuing to apply the AC signal includes continuing to apply the AC signal in a manner of increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply the AC signal in a manner of maintaining the voltage or current amplitude of the currently applied AC signal, and continuing to apply the AC signal in a manner of decreasing the voltage or current amplitude of the currently applied AC signal.

[0197] The operating state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal collected by the electrode unit 12. The electrode units 12 of the electrode sheet 10 are divided into different areas. The combination of the grounding switch 25 and the bidirectional switch 26 controls each electrode unit 12 in each area to cyclically switch between applying an AC signal and collecting a temperature detection signal.

[0198] This embodiment of the present application provides another electrode temperature detection method for the tumor electric field therapy system 100, please refer to Figure 26 As shown, the temperature detection method includes:

[0199] Step 510: disconnect the AC signal input to the electrode sheet 10, perform combination control on the multiple grounding switches 25 and the multiple bidirectional switches 26, and obtain the temperature detection signal of the temperature sensor 14 of the electrode sheet 10 corresponding to each combination in all combinations;

[0200] Step 520: sampling and converting the temperature detection signal detected by each temperature sensor 14 in the electrode sheet 10 to obtain a digital temperature signal;

[0201] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100, so that the electric field generator 30 determines the temperature at the corresponding electrode unit 12 according to the digital temperature signal.

[0202] In step 510, “combined control of the plurality of grounding switches 25 and the plurality of bidirectional switches 26” specifically includes:

[0203] Step 511: placing all bidirectional switches 26 at the acquisition terminal 1 to conduct electrical connections between the signal terminals 14 - 2 of the temperature sensors 14 of all electrode units 12 and the corresponding analog-to-digital converters 23 ;

[0204] Step 512: Sequentially and individually closing one of the plurality of grounding switches 25 in a time-sharing manner to collect the temperature detection signals detected by the temperature sensors 14 of the electrode units 12 in the corresponding row group row by row.

[0205] In step 512 , sequentially and time-sharingly closing one of the plurality of grounding switches 25 can connect the detection channels electrically connected between the analog-to-digital converter 23 and each temperature sensor 14 in the row group corresponding to the closed grounding switch 25 .

[0206] In this way, the temperature detection signals of the corresponding temperature sensors 14 in each row group can be obtained in turn, and then after processing by the adapter 20 or the electric field generator 30, the corresponding temperatures of all electrode units 12 on the electrode sheet 10 can be obtained; thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0207] For the tumor electric field therapy system 100 of the embodiment of the present application, the temperature of a single electrode unit 12 can also be detected as needed. The specific process of the method for performing temperature detection on a certain electrode unit 12 of the electrode sheet 10 is as follows: disconnect the input of the AC signal, place the bidirectional switch 26 corresponding to the column group where the electrode unit 12 that needs to be individually measured is located at the acquisition end 1, and place the remaining bidirectional switches 26 at the input end 2; at the same time, turn on and ground the ground switch 25 corresponding to the row group where the electrode unit 12 that needs to be individually measured is located, and disconnect all the remaining ground switches 25. In this way, the temperature detection signal of the temperature sensor 14 in the electrode unit 12 that needs to be individually measured can be sampled to obtain the temperature of the electrode unit 12. For example, if the electrode unit 12 that requires independent temperature measurement is electrode unit 12-1, the AC signal switch 35 corresponding to the electric field generator 30 is disconnected, the first bidirectional switch 26-1 corresponding to electrode unit 12-1 is placed at acquisition terminal 1, and the remaining bidirectional switches (second bidirectional switch 26-2, second bidirectional switch 26-3, third bidirectional switch 26-3, and fourth bidirectional switch 26-4) are all placed at input terminal 2. At the same time, the first grounding switch 25-1 corresponding to electrode unit 12-1 is closed and grounded, and the remaining grounding switches (second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4) are all disconnected. In this way, the temperature of electrode unit 12-1 can be detected.

[0208] The present application also provides another method for applying an AC signal for tumor electric field therapy, which is applied to the above-mentioned tumor electric field therapy system 100. Figure 27 As shown, the AC signal applying method includes:

[0209] Step 610: Determine the area of ​​the electrode unit 12 in the electrode sheet 10 where the alternating current signal needs to be applied;

[0210] Step 611: Combining and controlling the plurality of grounding switches 25 and the plurality of bidirectional switches 26 electrically connected to the electrode sheet 10 to apply an alternating current signal.

[0211] In step 611, “combining and controlling the plurality of grounding switches 25 and the plurality of bidirectional switches 26 electrically connected to the electrode sheet 10” is specifically as follows:

[0212] Step 612: Disconnect all grounding switches 25 electrically connected to the electrode sheet 10;

[0213] Step 613: determining the column group where the electrode units 12 to which the AC signal needs to be applied are located according to the area where the electrode units 12 to which the AC signal needs to be applied are located;

[0214] Step 614: Determine the bidirectional switches 26 electrically connected to the electrode units 12 in the column groups according to the column groups where the electrode units 12 to which the AC signals need to be applied are located;

[0215] In step 610 , every four adjacent electrode units 12 in the electrode sheet 10 are divided into a region. The four electrode units 12 in each region correspond to a column group and are connected to a dual-purpose signal line 19 corresponding to the same bidirectional switch 26 .

[0216] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which an AC signal needs to be applied so that the electrode unit 12 to which an AC signal needs to be applied is electrically connected to the AC signal line 28 to apply the AC signal; at the same time, control the remaining bidirectional switching switches 26 so that the electrical connection between each electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28 is disconnected to stop applying the AC signal.

[0217] In step 615, "electrically connecting the electrode units to which an AC signal needs to be applied to the AC signal line 28 to apply the AC signal and disconnecting the electrical connection between the electrode units 12 in the area where the AC signal does not need to be applied and the AC signal line 28 to stop applying the AC signal" is achieved by placing the bidirectional switching switch 26 electrically connected to the electrode units 12 in the column group corresponding to the area to which the AC signal is to be applied in the electrode sheet 10 at its input end 2, and placing all the bidirectional switching switches 26 electrically connected to the electrode units 12 in the remaining column groups at the collection end 1.

[0218] The first controller 22 or the electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of the embodiment of the present application is provided with a preset quantity threshold, a first preset temperature t1, a second preset temperature t2 and a preset temperature threshold t0, wherein the first preset temperature t1 is lower than the second preset temperature t2, and the second preset temperature t2 is lower than the preset temperature threshold t0.

[0219] The present application also provides a method for applying an AC signal based on a temperature detection signal, which is used in the above-mentioned tumor electric field treatment system 100. Figure 28 As shown, the application method includes:

[0220] Step 710: Start the tumor treating field system 100;

[0221] Step 711: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10;

[0222] Step 712: Combine and control the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10;

[0223] Step 713: Determine whether there is an electrode unit 12 whose temperature exceeds the first preset temperature t1. If there is no electrode unit 12 whose temperature exceeds the first preset temperature t1, execute step 714. If there is an electrode unit 12 whose temperature exceeds the first preset temperature t1, execute step 715.

[0224] Step 714: Continue applying the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the currently applied AC signal and return to step 712;

[0225] Step 715: Determine whether there is an electrode unit 12 whose temperature exceeds the second preset temperature t2; if there is no electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 716; if there is an electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 717;

[0226] Step 716: Continue applying the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that maintains the voltage or current amplitude of the currently applied AC signal unchanged and return to step 712;

[0227] Step 717: Determine whether there is an electrode unit 12 whose temperature exceeds the preset temperature threshold t0. If there is no electrode unit 12 whose temperature exceeds the preset temperature threshold t0, execute step 718; if there is an electrode unit whose temperature exceeds the preset temperature threshold t0, execute step 719;

[0228] Step 718: Continue applying the AC signal to all electrode units 12 of the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 712;

[0229] Step 719: Determine the number of over-temperature regions and execute step 720, wherein the over-temperature region is a region containing electrode units whose temperatures exceed the preset temperature threshold t0, and the non-over-temperature region is a region in which the temperatures of all electrode units do not exceed the preset temperature threshold t0;

[0230] Step 720: Determine whether the number of over-temperature areas exceeds a preset number threshold. If the number of over-temperature areas exceeds the preset number threshold, execute step 721. If the number of over-temperature areas does not exceed the preset number threshold, execute step 724.

[0231] Step 721: Stop applying the AC signal to each electrode unit 12 of the electrode sheet 10 and execute step 722;

[0232] Step 722: Combine and control the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10 and execute step 723;

[0233] Step 723: Determine whether there is an electrode unit 12 with a temperature exceeding the first preset temperature t1. If no electrode unit 12 with a temperature exceeding the first preset temperature t1 exists in the electrode sheet 10, the process returns to step 711. If no electrode unit 12 with a temperature exceeding the first preset temperature t1 exists in the electrode sheet 10, the process returns to step 722.

[0234] Step 724: Distinguish between an over-temperature area and a non-over-temperature area based on whether the area contains an electrode unit 12 whose temperature exceeds the preset temperature threshold t0. If the area is an over-temperature area, execute step 725; if the area is a non-over-temperature area, execute step 726.

[0235] Step 725: Stop applying the AC signal to each electrode unit 12 in the over-temperature area and execute step 731;

[0236] Step 726: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the first preset temperature t1. If the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the first preset temperature t1, execute step 727. If the temperature of each electrode unit 12 in the non-overtemperature area exceeds the first preset temperature t1, execute step 728.

[0237] Step 727: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 by increasing the voltage or current amplitude of the currently applied AC signal and execute step 731;

[0238] Step 728: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2. If the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2, execute step 729. If the temperature of each electrode unit 12 in the non-overtemperature area exceeds the second preset temperature t2, execute step 730.

[0239] Step 729: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature region of the electrode sheet 10 in a manner that maintains the voltage or current amplitude of the currently applied AC signal unchanged and execute step 731;

[0240] Step 730: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 by reducing the voltage or current amplitude of the currently applied AC signal and execute step 731;

[0241] Step 731: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to re-acquire the temperature of each electrode unit 12 of the electrode sheet 10 and selecting to execute step 732 or step 734. The temperature of each electrode unit 12 of the electrode sheet 10 includes the temperature of each electrode unit 12 in the over-temperature area and the temperature of each electrode unit 12 in the non-over-temperature area.

[0242] Step 732: Determine whether the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1. If the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1, execute step 733. If the temperature of each electrode unit 12 in the over-temperature area exceeds the first preset temperature t1, return to step 731.

[0243] Step 733: re-determine the area as a non-overtemperature area and execute step 734;

[0244] Step 734: Determine whether the temperatures of the electrode units 12 in the non-overtemperature area do not exceed the first preset temperature t1. If the temperatures of the electrode units 12 in the non-overtemperature area do not exceed the first preset temperature t1, execute step 735. If any of the temperatures of the electrode units 12 in the non-overtemperature area exceeds the first preset temperature t1, execute step 736.

[0245] Step 735: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area by increasing the voltage or current amplitude of the currently applied AC signal and return to step 712;

[0246] Step 736: Determine whether the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the second preset temperature t2. If the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the second preset temperature t2, execute step 737. If any of the temperatures of the electrode units 12 in the non-overtemperature region exceeds the second preset temperature t2, execute step 738.

[0247] Step 737: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area in a manner that maintains the voltage or current amplitude of the currently applied AC signal unchanged and return to step 712;

[0248] Step 738: Determine whether the temperatures of the electrode units 12 in the non-overtemperature area do not exceed the preset temperature threshold t0. If the temperatures of the electrode units 12 in the non-overtemperature area do not exceed the preset temperature threshold t0, execute step 739. If any of the temperatures of the electrode units 12 in the non-overtemperature area exceeds the preset temperature threshold t0, return to step 719.

[0249] Step 739 : Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area by reducing the voltage or current amplitude of the currently applied AC signal and return to step 712 .

[0250] Among them, Figure 22 As shown, the process of combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 in step 711 to apply an AC signal to each electrode unit 12 of the electrode sheet is specifically as follows:

[0251] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheets 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 to the end that applies an AC signal to each electrode unit 12; or

[0252] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheet 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheet 10 to one end that electrically connects each electrode unit 12 to the AC signal line 28; or

[0253] All grounding switches 25 electrically connected to the corresponding electrode sheets 10 are disconnected, and at the same time, all bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 are switched to their respective input terminals 2 .

[0254] The process of obtaining the temperature of each electrode unit 12 of the electrode sheet 10 in steps 712, 722, and 731 is specifically as follows:

[0255] Controlling the bidirectional switches 26 electrically connected to the electrode sheet 10 to switch from the end thereof for applying an AC signal to each electrode unit 12 to the end thereof for collecting the temperature of each electrode unit 12, and sequentially closing the grounding switches 25 electrically connected to the electrode units 12 of the electrode sheet 10 in a time-division manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0256] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all input terminals 2 for applying AC signals to the electrode units 12 to the acquisition terminal 1 thereof, and sequentially closing the grounding switches 25 electrically connected to the electrode units 12 of the electrode sheet 10 in a time-division manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0257] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23, and sequentially closing the grounding switch 25 electrically connected to each electrode unit 12 of the electrode sheet 10 in a time-sharing manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0258] The bidirectional switching switch 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an AC signal to transmitting a DC signal or a temperature detection signal, and the grounding switch 25 electrically connected to each electrode unit 12 of the electrode sheet 10 is closed in sequence in a time-sharing manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10.

[0259] The first preset temperature in steps 713, 723, 726, 732, and 734 is 40°C to 40.3°C, preferably 40.2°C. The second preset temperature in steps 715, 728, and 736 is 40.4°C to 40.6°C, preferably 40.5°C. The preset temperature threshold in steps 717 and 738 is 41°C to 41.5°C, preferably 41°C. The preset quantity threshold in step 720 is preferably 2.

[0260] The process of continuing to apply the AC signal in steps 714, 716, 718, 727, 729, 730, 735, 737, and 739 is specifically as follows:

[0261] Disconnecting the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, and simultaneously controlling the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied to connect the AC signal transmission path electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, thereby continuing to apply the AC signal to the electrode unit 12 to which the AC signal needs to continue to be applied; or

[0262] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied to switch from its respective collection end 1 to its respective input end 2 so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0263] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and simultaneously control the input ends 2 of the bidirectional switches 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied so that the input ends 2 thereof are electrically connected to the AC signal line 28, thereby continuing to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0264] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and simultaneously control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied so that their respective input terminals 2 are closed and the collection terminal 1 is disconnected, thereby continuing to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0265] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, and at the same time control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied so that the electrode unit 12 to which the AC signal needs to continue to be applied switches from transmitting the temperature detection signal to applying the AC signal.

[0266] Increasing the voltage or current amplitude of the currently applied AC signal in steps 714 , 727 , and 735 specifically involves boosting the voltage of the currently applied AC signal in a manner of a DC voltage amplitude increment of 0.03 V per second.

[0267] Continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal in steps 718, 730, and 739 specifically involves continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal by 5V and for 3 minutes.

[0268] The process of stopping applying the AC signal to each electrode unit 12 of the electrode sheet 10 in step 721 is specifically as follows:

[0269] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to disconnect the electrical connection between each electrode unit 12 of the electrode sheet 10 and the AC signal line 28; or

[0270] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch from the end where the AC signal is applied to each electrode unit 12 to the end where the temperature of each electrode unit 12 is collected; or

[0271] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all input terminals 2 for applying AC signals to the electrode units 12 to the collection terminals 1 thereof; or

[0272] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from electrically connecting each electrode unit 12 with the AC signal line 28 to electrically connecting each electrode unit 12 with the corresponding analog-to-digital converter 23; or

[0273] The bidirectional switch 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0274] The process of stopping applying the AC signal to each electrode unit 12 in the over-temperature area in step 725 is specifically as follows:

[0275] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area to disconnect the electrical connection between each electrode unit 12 in the over-temperature area and the AC signal line 28; or

[0276] Control the bidirectional switches 26 electrically connected to the electrode units 12 in the over-temperature zone to switch all ends thereof from one end thereof applying an AC signal to the electrode units 12 in the over-temperature zone to one end thereof enabling the electrode units 12 in the over-temperature zone to collect temperature; or

[0277] Control the bidirectional switches 26 electrically connected to the electrode units 12 in the over-temperature region to switch all input terminals 2 for applying AC signals to the electrode units 12 in the over-temperature region to the collection terminals 1 thereof; or

[0278] Controlling the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch each electrode unit 12 in the over-temperature region from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23; or

[0279] The bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area is controlled to switch each electrode unit 12 in the over-temperature area from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0280] In the aforementioned application method, the tumor therapy field system 100 includes at least two pairs of electrode sheets 10, which alternately apply alternating electric fields in different directions. Each electrode sheet 10 can alternate between applying an AC signal and transmitting a temperature detection signal. The electrode units 12 of the same electrode sheet 10 apply AC signals and DC signals for temperature measurement at different, non-overlapping time periods.

[0281] The first controller 22 or electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of the present embodiment is further provided with a third preset temperature t3, which is higher than the second preset temperature t2 but still lower than the preset temperature threshold t0. The third preset temperature t3 is closer to the preset temperature threshold t0 than the second preset temperature t2. The present embodiment also provides an AC signal control method based on a temperature detection signal for use in the above-mentioned tumor electric field therapy system, Figure 29 As shown, the AC signal control method includes:

[0282] Step 810: Start the tumor treating field system 100;

[0283] Step 811: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10;

[0284] Step 812: Combine and control the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10;

[0285] Step 813: Determine whether there is an electrode unit 12 whose temperature exceeds the first preset temperature t1. If there is no electrode unit 12 whose temperature exceeds the first preset temperature t1, execute step 814. If there is an electrode unit 12 whose temperature exceeds the first preset temperature t1, execute step 815.

[0286] Step 814: Continue applying the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0287] Step 815: Determine whether there is an electrode unit 12 whose temperature exceeds the second preset temperature t2; if there is no electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 816; if there is an electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 817;

[0288] Step 816: Continue applying the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that keeps the voltage or current amplitude of the currently applied AC signal unchanged and return to step 812;

[0289] Step 817: Determine whether there is an electrode unit 12 whose temperature exceeds the third preset temperature t3. If there is no electrode unit 12 whose temperature exceeds the third preset temperature t3, execute step 818; if there is an electrode unit whose temperature exceeds the third preset temperature t3, execute step 819.

[0290] Step 818: Continue applying the AC signal to all electrode units 12 of the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0291] Step 819: Determine whether there is an electrode unit 12 whose temperature exceeds the preset temperature threshold t0. If there is no electrode unit 12 whose temperature exceeds the preset temperature threshold t0, execute step 820; if there is an electrode unit whose temperature exceeds the preset temperature threshold t0, execute step 821.

[0292] Step 820: Continue applying the AC signal to all electrode units 12 of the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0293] Step 821: Determine the number of over-temperature regions and execute step 822, wherein the over-temperature region is a region containing electrode units whose temperatures exceed a preset temperature threshold t0, and the non-over-temperature region is a region in which the temperatures of all electrode units do not exceed the preset temperature threshold t0;

[0294] Step 822: Determine whether the number of over-temperature areas exceeds a preset number threshold. If the number of over-temperature areas exceeds the preset number threshold, execute step 823. If the number of over-temperature areas does not exceed the preset number threshold, execute step 826.

[0295] Step 823: Stop applying the AC signal to each electrode unit 12 of the electrode sheet 10 and execute step 824;

[0296] Step 824: Combine and control the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10 and execute step 825;

[0297] Step 825: Determine whether there is an electrode unit 12 with a temperature exceeding the first preset temperature t1. If no electrode unit 12 with a temperature exceeding the first preset temperature t1 exists in the electrode sheet 10, the process returns to step 811. If no electrode unit 12 with a temperature exceeding the first preset temperature t1 exists in the electrode sheet 10, the process returns to step 824.

[0298] Step 826: Distinguish between an over-temperature area and a non-over-temperature area based on whether the area contains an electrode unit 12 whose temperature exceeds the preset temperature threshold t0. If the area is an over-temperature area, execute step 827; if the area is a non-over-temperature area, execute step 828.

[0299] Step 827: Stop applying the AC signal to each electrode unit 12 in the over-temperature area and execute step 835;

[0300] Step 828: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the first preset temperature t1. If the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the first preset temperature t1, execute step 829. If the temperature of each electrode unit 12 in the non-overtemperature area exceeds the first preset temperature t1, execute step 830.

[0301] Step 829: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature region of the electrode sheet 10 by increasing the voltage or current amplitude of the currently applied AC signal and execute step 835;

[0302] Step 830: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2. If the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2, execute step 831. If the temperature of each electrode unit 12 in the non-overtemperature area exceeds the second preset temperature t2, execute step 832.

[0303] Step 831: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner that maintains the voltage or current amplitude of the currently applied AC signal unchanged and execute step 835;

[0304] Step 832: Determine whether any of the electrode units 12 in the non-overtemperature region has a temperature exceeding the third preset temperature t3. If none of the electrode units 12 in the non-overtemperature region has a temperature exceeding the third preset temperature t3, execute step 833. If any of the electrode units 12 in the non-overtemperature region has a temperature exceeding the third preset temperature t3, execute step 834.

[0305] Step 833: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 by reducing the voltage or current amplitude of the currently applied AC signal and execute step 835;

[0306] Step 834: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner that further reduces the voltage or current amplitude of the currently applied AC signal and execute step 835;

[0307] Step 835: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to re-acquire the temperature of each electrode unit 12 of the electrode sheet 10 and selecting to execute step 836 or step 838. The temperature of each electrode unit 12 of the electrode sheet 10 includes the temperature of each electrode unit 12 in the over-temperature area and the temperature of each electrode unit 12 in the non-over-temperature area.

[0308] Step 836: Determine whether the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1. If the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1, execute step 837. If the temperature of each electrode unit 12 in the over-temperature area exceeds the first preset temperature t1, return to step 835.

[0309] Step 837: re-determine the area as a non-overtemperature area and execute step 838;

[0310] Step 838: Determine whether the temperatures of the electrode units 12 in the non-overtemperature area do not exceed the first preset temperature t1. If the temperatures of the electrode units 12 in the non-overtemperature area do not exceed the first preset temperature t1, execute step 839. If any of the temperatures of the electrode units 12 in the non-overtemperature area exceeds the first preset temperature t1, execute step 840.

[0311] Step 839: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area by increasing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0312] Step 840: Determine whether the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the second preset temperature t2. If the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the second preset temperature t2, execute step 841. If any of the temperatures of the electrode units 12 in the non-overtemperature region exceeds the second preset temperature t2, execute step 842.

[0313] Step 841: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area in a manner that maintains the voltage or current amplitude of the currently applied AC signal unchanged and return to step 812;

[0314] Step 842: Determine whether the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the third preset temperature t3. If the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the third preset temperature t3, execute step 843. If any of the temperatures of the electrode units 12 in the non-overtemperature region exceeds the third preset temperature t3, execute step 844.

[0315] Step 843: Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area by reducing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0316] Step 844: Determine whether the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the preset temperature threshold t0. If the temperatures of the electrode units 12 in the non-overtemperature region do not exceed the preset temperature threshold t0, execute step 845. If any of the temperatures of the electrode units 12 in the non-overtemperature region exceeds the preset temperature threshold t0, return to step 821.

[0317] Step 845 : Continue applying the AC signal to each electrode unit 12 in the non-overtemperature area in a manner of further reducing the voltage or current amplitude of the currently applied AC signal and return to step 812 .

[0318] The process of combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 in step 811 to apply an AC signal to each electrode unit 12 of the electrode sheet is as follows:

[0319] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheets 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 to the end that applies an AC signal to each electrode unit 12; or

[0320] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheet 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheet 10 to one end that electrically connects each electrode unit 12 to the AC signal line 28; or

[0321] All grounding switches 25 electrically connected to the corresponding electrode sheets 10 are disconnected, and at the same time, all bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 are switched to their respective input terminals 2 .

[0322] The process of obtaining the temperature of each electrode unit 12 of the electrode sheet 10 in steps 812, 824, and 835 is specifically as follows:

[0323] Controlling the bidirectional switches 26 electrically connected to the electrode sheet 10 to switch from the end thereof for applying an AC signal to each electrode unit 12 to the end thereof for collecting the temperature of each electrode unit 12, and sequentially closing the grounding switches 25 electrically connected to the electrode units 12 of the electrode sheet 10 in a time-division manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0324] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all input terminals 2 for applying AC signals to the electrode units 12 to the acquisition terminal 1 thereof, and sequentially closing the grounding switches 25 electrically connected to the electrode units 12 of the electrode sheet 10 in a time-division manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0325] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23, and sequentially closing the grounding switch 25 electrically connected to each electrode unit 12 of the electrode sheet 10 in a time-sharing manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0326] The bidirectional switching switch 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an AC signal to transmitting a DC signal or a temperature detection signal, and the grounding switch 25 electrically connected to each electrode unit 12 of the electrode sheet 10 is closed in sequence in a time-sharing manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10.

[0327] The first preset temperature in steps 813, 825, 828, 836, and 838 is 40°C to 40.3°C, preferably 40.2°C. The second preset temperature in steps 815, 830, and 840 is 40.4°C to 40.6°C, preferably 40.5°C. The third preset temperature in steps 817, 832, and 842 is 40.7°C to 40.9°C, preferably 40.8°C. The preset temperature threshold in steps 819 and 844 is 41°C to 41.5°C, preferably 41°C. The preset quantity threshold in step 822 is preferably 2.

[0328] The process of continuing to apply the AC signal in steps 814, 816, 818, 820, 829, 831, 833, 834, 839, 841, 843, and 845 is specifically as follows:

[0329] Disconnecting the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, and simultaneously controlling the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied to connect the AC signal transmission path electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, thereby continuing to apply the AC signal to the electrode unit 12 to which the AC signal needs to continue to be applied; or

[0330] disconnecting the ground switch 25 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied, and simultaneously controlling the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied to switch from the collection end 1 thereof to the input end 2 thereof so as to continuously apply the AC signal to the electrode unit 12 to which the AC signal is to be continuously applied; or

[0331] disconnecting the ground switch 25 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied, and simultaneously controlling the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied to switch from the collection end 1 thereof to the input end 2 thereof so as to continuously apply the AC signal to the electrode unit 12 to which the AC signal is to be continuously applied; or

[0332] disconnecting the ground switch 25 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied, and simultaneously controlling the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied to switch from the collection end 1 thereof to the input end 2 thereof so as to continuously apply the AC signal to the electrode unit 12 to which the AC signal is to be continuously applied; or

[0333] disconnecting the ground switch 25 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied, and simultaneously controlling the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied to switch from the collection end 1 thereof to the input end 2 thereof so as to continuously apply the AC signal to the electrode unit 12 to which the AC signal is to be continuously applied; or

[0334] The way of increasing the voltage or current amplitude of the currently applied AC signal in the steps 814, 829, 839 to continuously apply the AC signal is specifically to continuously apply the AC signal after boosting the currently applied AC signal by a DC voltage amplitude increment of 0.03 V per second.

[0335] The way of decreasing the voltage or current amplitude of the currently applied AC signal in the steps 818, 820, 833, 834, 843, and 845 to continuously apply the AC signal is specifically to continuously apply the AC signal by a voltage amplitude of 5 V less than the voltage amplitude of the currently applied AC signal for 3 minutes.

[0336] The process of stopping the application of the AC signal to each electrode unit 12 of the electrode sheet 10 in the step 823 is specifically:

[0337] controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to disconnect the electrical connection between each electrode unit 12 of the electrode sheet 10 and the AC signal line 28; or

[0338] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch from the end where the AC signal is applied to each electrode unit 12 to the end where the temperature of each electrode unit 12 is collected; or

[0339] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all input terminals 2 for applying AC signals to the electrode units 12 to the collection terminals 1 thereof; or

[0340] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from electrically connecting each electrode unit 12 with the AC signal line 28 to electrically connecting each electrode unit 12 with the corresponding analog-to-digital converter 23; or

[0341] The bidirectional switch 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0342] The process of stopping applying the AC signal to each electrode unit 12 in the over-temperature area in step 827 is specifically as follows:

[0343] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area to disconnect the electrical connection between each electrode unit 12 in the over-temperature area and the AC signal line 28; or

[0344] Control the bidirectional switches 26 electrically connected to the electrode units 12 in the over-temperature zone to switch all ends thereof from one end thereof applying an AC signal to the electrode units 12 in the over-temperature zone to one end thereof enabling the electrode units 12 in the over-temperature zone to collect temperature; or

[0345] Control the bidirectional switches 26 electrically connected to the electrode units 12 in the over-temperature region to switch all input terminals 2 for applying AC signals to the electrode units 12 in the over-temperature region to the collection terminals 1 thereof; or

[0346] Controlling the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch each electrode unit 12 in the over-temperature region from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23; or

[0347] The bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area is controlled to switch each electrode unit 12 in the over-temperature area from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0348] When the tumor electric field therapy system 100 is in a standby state before starting operation, no AC signal is applied to the electrode unit 12. The first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the bidirectional switch 26 to switch to the acquisition end 1, the grounding switches 25 are turned on in sequence, and the analog-to-digital converter 23 receives the temperature detection signal of the temperature sensor 14 corresponding to each row of electrode units 12 in sequence.

[0349] When the first grounding switch 25 - 1 is turned on, the other grounding switches 25 are turned off, and the bidirectional switches 26 are all set to the acquisition end 1 , the analog-to-digital converter 23 receives the temperature detection signal of the temperature sensor 14 corresponding to the electrode unit 12 ;

[0350] When the second grounding switch 25 - 2 is turned on, the other grounding switches 25 are all turned off, and the bidirectional switches 26 are all set to the acquisition end 1 , the analog-to-digital converter 23 receives the temperature detection signal of the temperature sensor 14 corresponding to the electrode unit 12 ;

[0351] When the third grounding switch 25 - 3 is turned on, the other grounding switches 25 are turned off, and the bidirectional switches 26 are all set to the acquisition end 1 , the analog-to-digital converter 23 receives the temperature detection signal of the temperature sensor 14 corresponding to the electrode unit 12 ;

[0352] When the fourth grounding switch 25 - 4 is turned on, the other grounding switches 25 are turned off, and the bidirectional switches 26 are all set to the acquisition end 1 , the analog-to-digital converter 23 receives the temperature detection signal from the temperature sensor 14 corresponding to the electrode unit 12 .

[0353] The first controller 22 receives the temperature detection signal of the temperature sensor 14 corresponding to each electrode unit 12 through the analog-to-digital converter 23, and transmits it to the AC signal generator 34 of the electric field generator 30 through the first communication unit 27 and the second communication unit 33, and then controls or adjusts the AC signal applied to each electrode unit 12 through the second controller 32.

[0354] While various operations are depicted in the drawings as following a particular order, this should not be understood as requiring that these operations be performed in the particular order shown or in sequential order, nor should it be understood that all illustrated operations must be performed to achieve desirable results.

[0355] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some or all of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present application, and they should all be included in the scope of the claims and specification of the present application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. The present application is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

[0356] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some or all of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present application, and they should all be included in the scope of the claims and specification of the present application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. The present application is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

Claims

1. A tumor electric field treatment system, characterized in that: include: At least one pair of electrode sheets, the electrode sheet includes a plurality of electrode units and a flexible circuit board, the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on the circuit, each of the electrode units includes a temperature sensor having a signal terminal and a ground terminal; the flexible circuit board is configured for the plurality of electrode units to be arranged thereon at intervals, and a plurality of conductive traces are embedded in the flexible circuit board, the plurality of conductive traces include: a plurality of grounding lines and a plurality of dual-purpose signal lines, the plurality of grounding lines are connected to the plurality of row groups in a one-to-one correspondence, the ground terminals of the temperature sensors in the same row group are short-circuited by the same grounding line, and the ground terminals of the temperature sensors in different row groups are short-circuited by different grounding lines. The ground lines of the same path are connected in parallel, and the multiple dual-purpose signal lines are connected one-to-one with the multiple column groups. The signal ends of the temperature sensors in the same column group are short-circuited by the same dual-purpose signal line, and the signal ends of the temperature sensors in different column groups are connected in parallel by different dual-purpose signal lines. Each of the dual-purpose signal lines is configured to transmit an AC signal to each electrode unit in the corresponding column group in a first mode, and to transmit a DC signal to the temperature sensor of each electrode unit in the corresponding column group in a second mode for temperature detection and transmit the temperature detection signal detected by each electrode unit. The multiple ground lines are grounded separately in sequence in the second mode. an electric field generator configured to transmit an alternating current signal to a plurality of electrode units of the electrode sheet via a dual-purpose signal line of the electrode sheet; and An adapter is connected between the electrode sheet and the electric field generator, has multiple groups of circuit lines and is configured to transmit the AC signal generated by the electric field generator to the multiplexed signal line corresponding to the electrode sheet through the corresponding circuit lines in the corresponding group of multiplexed circuit lines, and is also configured to receive the temperature detection signal output by the multiplexed signal line of the electrode sheet through the corresponding circuit lines in the corresponding group of multiplexed circuit lines. Each group of multiplexed circuit lines is electrically connected one-to-one with the multiplexed signal line and the multiplexed ground lines corresponding to the electrode sheet, and some of the circuit lines in each group of multiplexed circuit lines are turned on when electrically connected to the corresponding electrode sheet to transmit AC signals, and the remaining circuit lines in each group of multiplexed circuit lines are turned on when electrically connected to the corresponding electrode sheet to transmit DC signals for temperature detection.

2. The tumor electric field treatment system according to claim 1, characterized in that: The adapter also includes multiple groups of bidirectional switching switches electrically connected one-to-one with multiple groups of circuit lines, each group of bidirectional switching switches is electrically connected one-to-one with the multi-channel dual-purpose signal lines corresponding to the electrode pieces and includes multiple bidirectional switching switches, and the multiple bidirectional switching switches in each group of bidirectional switching switches respectively control the multi-channel dual-purpose signal lines of the electrode pieces electrically connected thereto to switch between transmitting AC signals and transmitting DC signals.

3. The tumor electric field treatment system according to claim 2, characterized in that: The adapter includes multiple groups of grounding switches electrically connected one by one to multiple groups of circuit lines, and each group of grounding switches is also electrically connected one by one to the multiple grounding lines corresponding to the electrode sheets and includes multiple grounding switches that respectively control the conduction and disconnection of the multiple grounding lines corresponding to the electrode sheets electrically connected thereto.

4. The tumor electric field treatment system according to claim 3, characterized in that: The number of the bidirectional switches in each group is equal to the number of the dual-purpose signal lines corresponding to the electrode sheets, and the number of the grounding switches in each group is equal to the number of the grounding lines corresponding to the electrode sheets.

5. The tumor electric field treatment system according to claim 3 or 4, characterized in that: Each group of multiple circuit lines of the adapter further includes: an AC signal line configured to transmit alternating current signals to each of the electrode units in the corresponding column group of the electrode sheet through the multiple dual-purpose signal lines of the corresponding electrode sheet.

6. The tumor electric field treatment system according to claim 5, characterized in that: The adapter also includes: multiple groups of analog-to-digital converters, each group of analog-to-digital converters is electrically connected to the multiplexed signal line of the corresponding electrode sheet through the corresponding group of corresponding circuit lines, and is configured to receive the temperature detection signal transmitted by the multiplexed signal line of the corresponding electrode sheet through the corresponding group of corresponding circuit lines and convert the temperature detection signal from an analog signal to a digital signal, wherein each group of analog-to-digital converters includes multiple detection channels, and each of the bidirectional switches also has an acquisition end electrically connected to a corresponding detection channel in the corresponding analog-to-digital converter and an input end electrically connected to the AC signal line.

7. The tumor electric field treatment system according to claim 1, characterized in that: Each of the electrode units includes a dielectric element for transmitting an alternating current signal, and the dielectric element of each of the electrode units is short-circuited with a signal terminal of the temperature sensor.

8. The tumor electric field treatment system according to claim 7, characterized in that: Each of the electrode units further includes a diode connected in series with a temperature sensor, and the temperature sensor is grounded via the diode connected in series with the temperature sensor.

9. The tumor electric field treatment system according to claim 1, characterized in that: The plurality of electrode units are structurally arranged into multiple rows and columns, and the flexible circuit board is provided with a connection portion connecting two adjacent electrode units, wherein the electrode sheet is provided with a gap formed between two adjacent electrode units along the column direction and along the row direction.

10. The tumor electric field treatment system according to claim 3, characterized in that: When each electrode unit of the electrode sheet performs temperature detection, the multiple bidirectional switches electrically connected to the electrode sheet are placed at their respective collection ends, and only one of the multiple grounding switches electrically connected to the electrode sheet is turned on at the same time, and the others are turned off.

11. The tumor electric field treatment system according to claim 3, characterized in that: When the electrode units of the electrode sheet transmit an AC signal, all or part of the multiple bidirectional switches electrically connected to the electrode sheet are placed at the input end, and all of the multiple grounding switches electrically connected to the electrode sheet are disconnected.

12. The tumor electric field treatment system according to claim 6, characterized in that: The adapter also includes: The first controller is connected to the multiple groups of grounding switches and the multiple groups of bidirectional switches respectively, and is configured to: for sequentially and cyclically controlling the on / off states of a plurality of the grounding switches in each group of grounding switches, thereby sequentially and individually conducting each grounding line in the plurality of grounding lines of the corresponding electrode sheet; and It is used to control the switching state of multiple bidirectional switches in each group of bidirectional switches, so that each bidirectional switch is placed at its collection end to output a temperature detection signal or each bidirectional switch is placed at the input end to transmit an AC signal.

13. The tumor electric field treatment system according to claim 12, characterized in that: The adapter also includes: The first communication unit is configured to obtain the digital signals output by the multiple groups of analog-to-digital converters and send the digital signals to the electric field generator.

14. The tumor electric field treatment system according to claim 13, characterized in that: The electric field generator is further configured to control or adjust the alternating current signal transmitted to a corresponding electrode unit among the plurality of electrode units of the corresponding electrode sheet according to the received digital signal.

15. The tumor electric field treatment system according to claim 13, wherein: The first communication unit is controlled by the first controller and serially transmits the digital signal converted by the analog-to-digital converter.

16. A temperature detection method, characterized in that: Applied to the tumor electric field treatment system according to any one of claims 1 to 15, the method comprises the following steps: Turning on all the collecting ends of the multiplexed signal lines corresponding to the plurality of column groups of the corresponding electrode sheets; and Each of the multiple grounding lines corresponding to the plurality of row groups of the electrode sheet is sequentially and time-dividedly turned on to collect the temperature detection signal of each electrode unit in each row group of the electrode sheet by row through the multiplexed signal line.

17. A method for detecting temperature anomaly, characterized in that: The temperature abnormality is determined by using the temperature detection signal of each electrode unit of the electrode sheet obtained according to the method of claim 16 .

18. The method according to claim 17, characterized in that The temperature abnormality determination of the tumor electric field treatment system includes the following steps: comparing the obtained temperature of each of the electrode units with a preset temperature threshold; and It is determined whether the temperature of the electrode sheet is abnormal according to the comparison result.

19. The method according to claim 18, characterized in that The comparison result includes whether the temperature does not exceed the preset temperature threshold or exceeds the preset temperature threshold. Whether the temperature of the electrode sheet is abnormal is determined by the following method: When the temperature of one of the electrode units exceeds a preset temperature threshold, it is determined that the electrode sheet has a temperature abnormality; or When the temperatures of all electrode units of the electrode sheet do not exceed a preset temperature threshold, it is determined that no temperature abnormality occurs in the electrode sheet.

20. The method according to claim 18 or 19, characterized in that The preset temperature threshold is 40.5°C-41.5°C.

21. The method according to claim 20, characterized in that The preset temperature threshold is 41°C-41.5°C.

22. The method according to claim 21, characterized in that The preset temperature threshold is 41°C.

23. A tumor electric field treatment system, characterized in that: include: At least one pair of electrode sheets, the electrode sheet includes a plurality of electrode units and a flexible circuit board, the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on the circuit, each of the electrode units includes a temperature sensor having a signal end and a ground end; the flexible circuit board is configured for the plurality of electrode units to be arranged thereon at intervals, and a plurality of conductive traces are embedded in the flexible circuit board, the plurality of conductive traces including: a plurality of grounding lines and a plurality of dual-purpose signal lines, the plurality of grounding lines are connected to the plurality of row groups in a one-to-one correspondence, the ground ends of the temperature sensors in the same row group are short-circuited by the same grounding line, and the ground ends of the temperature sensors in different row groups are short-circuited by different grounding lines. The plurality of ground lines are connected in parallel, the plurality of dual-purpose signal lines are connected one-to-one with the plurality of column groups, the signal ends of the temperature sensors in the same column group are short-circuited by the same dual-purpose signal line, and the signal ends of the temperature sensors in different column groups are connected in parallel by different dual-purpose signal lines; each of the dual-purpose signal lines is configured to transmit an AC signal to each of the electrode units in the corresponding column group in a first mode, and to transmit a DC signal to the temperature sensor of each of the electrode units in the corresponding column group in a second mode for temperature detection and to transmit the temperature detection signal detected by each electrode unit; the plurality of ground lines are individually grounded in sequence in the second mode; and An adapter or an electric field generator electrically connected to the electrode sheet, the adapter or the electric field generator is configured to control the ground line and the dual-purpose signal line of the electrode sheet in combination so that the dual-purpose signal line electrically connecting the electrode sheet and each electrode unit is in the first mode or the second mode.

24. The tumor electric field treatment system according to claim 23, wherein: The adapter or the electric field generator is configured to control or adjust the alternating current signal applied to each electrode unit of the electrode sheet according to the acquired temperature detection signal of each electrode unit of the electrode sheet.

25. The tumor electric field treatment system according to claim 24, wherein: The adapter or the electric field generator has a preset temperature threshold and is configured to: comparing the obtained temperature of each of the electrode units with a preset temperature threshold; and The alternating current signal applied to each electrode unit of the electrode sheet is controlled or adjusted according to the comparison result.

26. The tumor electric field treatment system according to claim 24, wherein: The adapter or the electric field generator is configured as: When the temperature detection signals of the electrode units of the electrode sheet obtained do not exceed the preset temperature threshold, continue to apply the alternating current signal to the electrode units of the electrode sheet; or When one of the acquired temperature detection signals of the electrode units of the electrode sheet exceeds a preset temperature threshold, application of the alternating current signal to the electrode units of the electrode sheet is stopped.

27. The tumor electric field treatment system according to claim 26, wherein: Stopping applying AC signals to the electrode units of the electrode sheet includes stopping applying AC signals to all electrode units of the electrode sheet, stopping applying AC signals to electrode units in the electrode sheet whose temperature detection signals exceed a preset temperature threshold, and stopping applying AC signals to all electrode units in the column where the electrode units in the electrode sheet whose temperature detection signals exceed a preset temperature threshold are located.

28. The tumor electric field treatment system according to claim 27, wherein: The adapter or the electric field generator is further configured to: when stopping applying the AC signal to the electrode unit in the electrode sheet whose temperature detection signal exceeds the preset temperature threshold, continue applying the AC signal to the electrode unit in the electrode sheet whose temperature detection signal does not exceed the preset temperature threshold.

29. The tumor electric field treatment system according to claim 27, wherein: The adapter or the electric field generator is further configured to: when stopping applying the alternating current signal to all electrode units in the column where the electrode unit whose temperature detection signal exceeds the preset temperature threshold in the electrode sheet is located, continue applying the alternating current signal to all electrode units in the electrode sheet whose temperature detection signal does not exceed the preset temperature threshold and are in a different column from the electrode unit whose temperature detection signal exceeds the preset temperature threshold.

30. The tumor electric field treatment system according to claim 25, wherein: The comparison result includes not exceeding the preset temperature threshold and exceeding the preset temperature threshold. Not exceeding the preset temperature threshold includes being far below the preset temperature threshold and being close to the preset temperature threshold.

31. The tumor electric field treatment system according to claim 30, wherein: The adapter or the electric field generator is further configured to: when each temperature detection signal of the electrode sheet does not exceed a preset temperature threshold, continue to apply an alternating current signal to each electrode unit of the electrode sheet in the following manner: When the temperature detection signal is much lower than the preset temperature threshold, the AC signal is continued to be applied to each electrode unit of the electrode sheet in a manner of increasing the voltage or current amplitude of the AC signal currently applied to each electrode unit of the electrode sheet or in a manner of keeping the voltage or current amplitude of the AC signal currently applied to each electrode unit of the electrode sheet unchanged; or When the temperature detection signal approaches a preset temperature threshold, the AC signal continues to be applied to each electrode unit of the electrode sheet in a manner that keeps the voltage or current amplitude of the AC signal currently applied to each electrode unit of the electrode sheet unchanged, or continues to apply the AC signal to each electrode unit of the electrode sheet in a manner that reduces the voltage or current amplitude of the AC signal currently applied to each electrode unit of the electrode sheet.

32. The tumor treating field system according to any one of claims 26 to 31, wherein: The preset temperature threshold is 40.5°C-41.5°C.

33. The tumor electric field treatment system according to claim 32, wherein: The preset temperature threshold is 41°C-41.5°C.

34. The tumor electric field treatment system according to claim 33, wherein: The preset temperature threshold is 41°C.

35. A tumor electric field treatment system, characterized in that: include: At least one pair of electrode sheets, the electrode sheet includes a plurality of electrode units and a flexible circuit board, the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on the circuit, each of the electrode units includes a temperature sensor having a signal end and a ground end; the flexible circuit board is configured to accommodate the plurality of electrode units arranged thereon at intervals, and a plurality of conductive traces are embedded in the flexible circuit board, the plurality of conductive traces including: a plurality of grounding lines and a plurality of dual-purpose signal lines, the plurality of grounding lines are connected to the plurality of row groups in a one-to-one correspondence, the ground ends of the temperature sensors in the same row group are short-circuited by the same grounding line, and the temperature sensors in different row groups are short-circuited by the same grounding line. The ground terminals of the sensors are connected in parallel via different ground lines, the multiple dual-purpose signal lines are connected one-to-one with the multiple column groups, the signal terminals of the temperature sensors in the same column group are short-circuited via the same dual-purpose signal line, and the signal terminals of the temperature sensors in different column groups are connected in parallel via different dual-purpose signal lines; each dual-purpose signal line is configured to transmit both an alternating current signal to each electrode unit in the corresponding column group and a direct current signal to the temperature sensor of each electrode unit in the corresponding column group for temperature detection and to transmit the temperature detection signal detected by each electrode unit; as well as An adapter or an electric field generator electrically connected to the electrode sheet, the adapter or the electric field generator is configured to control the ground wire and the dual-purpose signal wire of the electrode sheet in combination to conduct the AC signal transmission path to transmit the AC signal to the electrode unit of the electrode sheet or to conduct each DC signal transmission path in sequence and time-sharing to collect the temperature detection signal of each electrode unit of the electrode sheet.

36. The tumor treating field system according to claim 35, wherein: The adapter or the electric field generator is configured to: combine and control the conduction and disconnection of the multiple dual-purpose signal lines that correspond one-to-one to each column group of the electrode sheet and are electrically connected to the electrode units of each column group, and the multiple ground lines that correspond one-to-one to each row group of the electrode sheet and are electrically connected to the electrode units of each row group, and realize the cyclic switching of each electrode unit of the electrode sheet between applying an alternating current signal and collecting or transmitting a temperature detection signal through the multiple dual-purpose signal lines that are electrically connected to each electrode unit of the electrode sheet.

37. The tumor electric field treatment system according to claim 36, wherein: The adapter or the electric field generator is configured to: disconnect the multiple grounding lines that are electrically connected one-to-one to the grounding ends of the temperature sensors of the electrode units in each row group of the electrode sheet, and at the same time connect the multiple dual-purpose signal lines that are electrically connected one-to-one to the electrode units in each column group of the electrode sheet so that the multiple dual-purpose signal lines electrically connected to the electrode sheet transmit alternating current signals to each electrode unit.

38. The tumor electric field treatment system according to claim 37, wherein: The adapter or the electric field generator is configured as: Conducting the plurality of dual-purpose signal lines electrically connected to the electrode units of each column group of the electrode sheet so that the plurality of dual-purpose signal lines electrically connected to the electrode sheet transmits a DC signal to each electrode unit; and One of the multiple grounding lines electrically connected to the ground ends of the temperature sensors of the electrode units in each row group of the electrode sheet is turned on in sequence and in a time-sharing manner to complete the transmission of the temperature detection signals of each electrode unit in each row group of the electrode sheet in a time-sharing manner and row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

39. The tumor electric field treatment system according to claim 38, wherein: The adapter or the electric field generator is further configured to: Determining, based on the acquired temperature detection signals of the electrode units, a combined control method for turning on or off the multiple ground lines corresponding to the row groups of the electrode sheet and the multiple dual-purpose signal lines corresponding to the column groups of the electrode sheet; as well as The working state of each electrode unit of the electrode sheet is controlled according to the determined combined control mode of conducting or disconnecting the multiple grounding lines and the multiple dual-purpose signal lines.

40. The tumor electric field treatment system according to claim 39, wherein: The working state of each electrode unit of the electrode sheet includes one of stopping applying the alternating current signal and continuing to collect the temperature detection signal and stopping collecting the temperature detection signal and continuing to apply the alternating current signal.

41. The tumor electric field treatment system according to claim 40, wherein: The continuing to apply the AC signal includes continuing to apply the AC signal in a manner of increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply the AC signal in a manner of keeping the voltage or current amplitude of the currently applied AC signal unchanged, or continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal.

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