A fully automatic card-type blood sample extraction device

Abstract

The present invention discloses a fully automatic card-type blood sample extraction device, comprising an analysis module and a grabbing module; an outlet is provided at the bottom of the grabbing module, and an inlet communicating with the outlet is provided at the top of the analysis module; the grabbing module comprises an upper box, a material box arranged in the upper box, and a grabbing mechanism; the analysis module comprises a lower box, a bracket arranged in the lower box, a detection card conveying mechanism arranged on the bracket, a detection mechanism, and an elution mechanism; the elution mechanism comprises a first sealing joint and a second sealing joint arranged at the front and rear, the first sealing joint being provided with a first flow channel, forming a first cavity communicating with the first flow channel at the rear end, the second sealing joint being provided with a second flow channel, forming a second cavity communicating with the second flow channel at the front end, and when the two cavities are close together, an elution cavity is formed. The present invention can conveniently and quickly elute the blood sample on the detection card, saving detection costs.

Description

Technical Field

[0001] The present invention relates to the technical field of experimental instruments, in particular to a fully automatic card-type blood sample extraction device. Background Art

[0002] Dried blood spots (DBS) are a mature and advanced method for blood collection and storage. Blood is deposited from a fingertip or heel onto a filter paper card and dried at room temperature for at least two hours. After preparation, it can be stored and transported at room temperature. In recent years, dried blood spot technology has overcome the challenges of high blood storage requirements and the susceptibility of components to transformation, enhancing the stability of compounds in biological samples and enabling long-term storage and transport of blood samples at room temperature. As a promising alternative to liquid blood sample collection, DBS has been widely used in clinical fields such as disease marker detection, drug monitoring, and pharmacokinetic research, as well as in metabolomics, doping screening, and forensic identification. Existing DBS testing equipment first requires punching a hole in the blood sample from the card, then adding a solvent to extract the sample. After mixing and centrifugation, the sample is converted into a liquid, which is then separated and analyzed by liquid chromatography-mass spectrometry. This process is cumbersome, requires high material costs, and is time-consuming. Summary of the Invention

[0003] The purpose of the present invention is to provide a fully automatic card-type blood sample extraction device, which can conveniently and quickly elute the blood sample on the test card online and save testing costs.

[0004] The purpose of the present invention can be achieved through the following technical solutions:

[0005] A fully automatic card-type blood sample extraction device comprises an analysis module and a grabbing module arranged on the analysis module; an outlet is provided at the bottom of the grabbing module, and an inlet connected to the outlet is provided at the top of the analysis module, and a detection card channel is formed between the outlet and the inlet; the grabbing module comprises an upper box body, a plurality of material boxes for storing detection cards arranged at the bottom position of the upper box body, and a grabbing mechanism for grabbing the detection card; the analysis module comprises a lower box body, a bracket arranged in the lower box body, a detection card conveying mechanism arranged on the bracket, a detection mechanism for detecting the position of the blood sample on the detection card, an elution mechanism for eluting the blood sample from the detection card with the blood sample that has arrived, and an elution mechanism for eluting the detection card after the elution is completed. A drying system for drying; the elution mechanism includes a first tight joint and a second tight joint arranged at the front and rear, a gap is provided between the first tight joint and the second tight joint for the detection card to pass through, and a tight joint driving motor is provided behind the second tight joint to drive the second tight joint to move toward the first tight joint, a first flow channel is provided in the first tight joint, and a first cavity communicating with the first flow channel is formed at the rear end, and a second flow channel is provided in the second tight joint, and a second cavity communicating with the second flow channel is formed at the front end, wherein the first flow channel, the first cavity, the second flow channel and the second cavity are all coaxially arranged, the openings of the two cavities are the same size, and when the two cavities are close together, an elution cavity is formed.

[0006] Using this technical solution, during operation, the test card containing the blood sample is transferred to the gap between the first and second sealing joints. When the two cavities come together, they form an elution chamber, into which the blood sample on the test card is precisely located. Subsequently, eluent flows through the second flow channel, passes through the elution chamber, and exits the first flow channel, freeing the blood sample from the test card. This avoids the need, as in the prior art, to first punch a hole to remove the test strip containing the dried blood sample, dissolve it, and centrifuge it to produce a liquid sample before proceeding to the next step of analysis, thereby speeding up the testing process.

[0007] In a specific embodiment of the present invention, the volume of the first cavity is larger than that of the second cavity, the first cavity is conical, and the second cavity is flat. This structure allows the second cavity to be quickly filled with eluent due to its flat shape and small volume, ensuring sufficient contact between the eluent and the blood sample on the test card. The conical shape and larger volume of the first cavity create a pressure differential with the second cavity, promoting the penetration of the eluent and enhancing the fluidity of the liquid passing through the test card, making it easier for the blood sample to be removed from the test card.

[0008] In a specific embodiment of the present invention: it also includes a heating element installed in the lower box body, the drying system, the heating element, the first tight joint and the second tight joint are connected through the same control pipeline, and a flow valve for controlling switching is also connected to the control pipeline.

[0009] In a specific embodiment of the present invention: an electric turntable is provided at the bottom of the upper box body, and a plurality of material boxes are evenly spaced on the electric turntable. The gripping mechanism includes a clamp, a clamp lifting assembly for driving the clamp to lift and lower, a clamp longitudinal movement assembly for driving the clamp longitudinally, and a clamp transverse movement assembly for driving the clamp transversely.

[0010] In a specific embodiment of the present invention: the test card conveying mechanism includes a clamp located below the inlet, a clamp translation assembly for driving the clamp to translate laterally, and a clamp lifting assembly for driving the clamp to move up and down.

[0011] In a specific embodiment of the present invention, the clamp lifting assembly includes a U-shaped frame with a middle portion hinged to a bracket and a drive motor located at the rear of the U-shaped frame for driving the tail portion of the U-shaped frame to rise and fall.

[0012] In a specific embodiment of the present invention: the clamp translation assembly includes a support base fixed to the front end of the U-shaped frame, a motor fixed on the support base and a pulley, two pulleys are fixed at both ends of the support base, and belts are provided on the two pulleys, one of the pulleys is connected to the motor through a rotating shaft, the clamp is fixedly connected to the belt, a plurality of guide wheels are provided on the support base, and the belt passes around all the guide wheels in turn, the clamp is located at the front end of the U-shaped frame and is fixedly connected to the belt, a transverse guide rail is fixed on the support base in front of the belt, a transverse slider is slidably connected to the transverse guide rail, and the clamp is fixed on the transverse slider.

[0013] In a specific embodiment of the present invention: the elution mechanism further includes an elution bracket, the first tight joint is installed on the elution bracket via a first connector, and the second tight joint is installed on the elution bracket via a second connector.

[0014] In a specific embodiment of the present invention: the first connecting member includes a first fixing block and a first clamping block, the first fixing block is fixed to the bottom surface of the elution bracket, the bottom surface of the first fixing block is provided with a transverse blind groove, the first clamping block is installed in the blind groove, the first clamping block is provided with a first clamping hole, and the first sealing joint is installed in the first clamping hole.

[0015] In a specific embodiment of the present invention: the second connecting member includes a second fixed block and a second clamping block, the second fixed block is fixed to the bottom surface of the elution bracket and is located on the rear side of the first fixed block, the bottom surface of the second fixed block is provided with a longitudinal slide groove, the second clamping block is slidably set in the slide groove, the second clamping block is provided with a second clamping hole, and the second sealing joint is installed in the second clamping hole.

[0016] In summary, the present invention comprises a first flow channel within the first seal joint, forming a first cavity at the rear end that communicates with the first flow channel. A second flow channel is disposed within the second seal joint, forming a second cavity at the front end that communicates with the second flow channel. When the two cavities are brought together, they form an elution chamber. When a blood sample on the test card is located within the elution chamber, the eluent flows into the second flow channel, passes through the elution chamber, and exits the first flow channel, rapidly detaching the blood sample from the test card. This accelerates the elution process, while also simplifying the structure and reducing costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention will be further described below with reference to the accompanying drawings.

[0018] Figure 1 This is a structural schematic diagram of a fully automatic card-type blood sample extraction device of the present invention;

[0019] Figure 2 It is a structural schematic diagram of the analysis module of the present invention;

[0020] Figure 3 It is a structural schematic diagram of the grabbing mechanism of the present invention;

[0021] Figure 4 It is a structural schematic diagram of the upper box body of the present invention;

[0022] Figure 5 It is a structural schematic diagram of the analysis module of the present invention;

[0023] Figure 6 It is a structural schematic diagram of the detection card transmission mechanism of the present invention;

[0024] Figure 7 It is a structural schematic diagram of the elution mechanism of the present invention;

[0025] Figure 8 The test card is shown to be transferred to the gap between the first tight joint and the second tight joint;

[0026] Figure 9 It shows that when the two cavities are close together, an elution cavity is formed, and the blood sample on the test card is located exactly in the elution cavity;

[0027] Figure 10 It is a structural schematic diagram of the first tight joint of the present invention;

[0028] Figure 11 1 is a schematic structural diagram of a second tight joint of the present invention;

[0029] Figure 12 It is a structural schematic diagram of the detection card of the present invention;

[0030] Figure 13 is a schematic structural diagram of the first connecting member of the present invention;

[0031] Figure 14 It is a structural schematic diagram of the quick-change mechanism of the present invention;

[0032] Figure 15 is an exploded view of the first connecting member of the present invention;

[0033] Figure 16 is a schematic structural diagram of the second connecting member of the present invention;

[0034] Figure 17 is a flow chart showing the eluent. DETAILED DESCRIPTION

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0036] See also Figure 1 As shown, the present invention is a fully automatic card-type blood sample extraction device, which includes an analysis module 10 and a grabbing module 20 detachably arranged on the analysis module.

[0037] Combine Figure 2 As shown, the grabbing module 20 includes an upper box 21, a plurality of storage devices provided in the upper box 21, Figure 12 A material box 22 for the detection card 9 and a grabbing mechanism 23 for grabbing the detection card 9.

[0038] A motorized turntable 24 is located at the bottom of the upper housing 21, with multiple cassettes 22 spaced evenly apart. In this embodiment, there are four cassettes 22. An outlet 211 is located at the bottom of the upper housing 21, in front of the motorized turntable 24. Each cassette 22 has multiple slots spaced evenly apart, each housing a corresponding slot for multiple test cards 9. Using this technical solution, once all test cards containing blood samples in the current cassette have been eluted, the motorized turntable 24 rotates, moving the next cassette 22 beneath the gripping mechanism 23 for a new elution cycle.

[0039] Combine Figure 3As shown, the gripping mechanism 23 includes a clamping jaw bracket 231 fixed in the upper box body 21, a clamping jaw longitudinal movement assembly 232 fixed on the clamping jaw bracket 231, a horizontal slide 233 installed on the output end of the clamping jaw longitudinal movement assembly 232, a clamping jaw transverse movement assembly 236 fixed on the horizontal slide 233, a clamping jaw lifting assembly 234 installed on the output end of the clamping jaw transverse movement assembly 236, a lifting slide 235 installed on the output end of the clamping jaw lifting assembly 234, and a clamping jaw 238 installed on the lifting slide 235 and driven to open and close by a clamping jaw cylinder 237.

[0040] In this embodiment, the clamping jaw lifting assembly 234 , the clamping jaw longitudinal movement assembly 232 , and the clamping jaw transverse movement assembly 236 all adopt linear modules driven by servo motors.

[0041] like Figure 4 and Figure 5 As shown, the analysis module 10 includes a lower box body 11, a bracket 17 provided at the bottom of the lower box body 11, a detection card conveying mechanism 12 provided on the bracket 17, a detection mechanism 13 for detecting the position of the blood sample on the detection card 9, and an elution mechanism 14 for eluting the blood sample from the arrived detection card 9 with the blood sample using an elution fluid.

[0042] An inlet 111 communicating with the outlet 211 is provided on the top of the lower box body 11 , and a detection card channel is formed between the outlet 211 and the inlet 111 .

[0043] Combine Figure 6 As shown, the test card conveying mechanism 12 includes a clamp 121 located below the inlet 111, a clamp translation assembly 122 for driving the clamp to translate laterally, and a clamp lifting assembly 123 for driving the clamp to lift. The clamp 121 is used to receive the test card 9 output by the clamping claw 238.

[0044] The fixture lifting assembly 123 includes a U-shaped frame 1232 whose middle portion is hinged to the bracket 17 and a driving motor 1233 located at the rear of the U-shaped frame 1232 for driving the tail portion of the U-shaped frame 1232 to move up and down.

[0045] The fixture translation assembly 122 includes a support base 1221 fixed to the front end of a U-shaped frame 1232, a transverse motor 1222 fixed to the support base 1221, and a pulley 1223. Two pulleys 1223 are fixed to both ends of the support base 1221. Belts 1224 are sleeved on the two pulleys 1223, and one of the pulleys 1223 is connected to the motor 1222 via a rotating shaft. A plurality of guide pulleys 1225 are provided on the support base 1221, and the belt 1224 passes around all of the guide pulleys 1225 in sequence. The fixture 121 is located at the front end of the U-shaped frame and is fixedly connected to the belt 1224. A transverse guide rail 1226 is fixed to the support base 1221 in front of the belt 1224. A transverse slider 1227 is slidably connected to the transverse guide rail 1226, and the fixture 121 is fixed to the transverse slider 1227. When the fixture 121 is driven to move laterally, it has a first stop position and a second stop position. When the clamp 121 is located directly below the inlet 111 , it is the first stop position. When the clamp 121 is located at the elution mechanism, it is the second stop position.

[0046] In addition, vertical guide rails 15 are respectively provided on both sides of the support base 1221 at the bottom of the bracket 17, and vertical sliders 16 are slidably connected to the vertical guide rails 15. The two ends of the support base 1221 are fixedly connected to the corresponding vertical sliders 16 respectively.

[0047] Near the afterbody of U-shaped frame 1232, be provided with the first sensor 124.On the inner side surface of support base 1221 left and right sides, be respectively installed with the second sensor 125 and the third sensor 126.All sensors are electrically connected with controller (not shown).When fixture 121 is positioned at the first stop position, the third sensor 126 detects fixture 121, and transmits signal to controller, and controller control drive motor 1233 starts, drives U-shaped frame 1232 afterbody to descend.When the first sensor 124 detects U-shaped frame 1232 afterbody (being that the afterbody of U-shaped frame 1232 is in low position, and after the front end of U-shaped frame 1232 rises, is in high position), drive motor 1233 stops, afterwards, controller control clamp 238 descends and detects card 9 and inserts in fixture 121.Subsequently, controller control drive motor 1233 drives U-shaped frame 1232 afterbody to rise slightly, makes U-shaped frame 1232 front end descend slightly, drives fixture 121 to descend slightly. Afterwards, the transverse motor 1222 is started and drives the clamp 121 to move to the second stop position. The second sensor 125 detects the clamp 121 and transmits a signal to the controller. The controller controls the transverse motor 1222 to stop and then performs the next action.

[0048] The detection mechanism 13 includes a camera light source 131 located behind the first stop position and a detection camera 132 located behind the camera light source 131. The detection camera 132 and the camera light source 131 are both electrically connected to the controller.

[0049] Combine Figure 7 and Figure 8 As shown, the elution mechanism 14 includes an elution support 141, a first sealing joint 142 and a second sealing joint 143 installed in front and back of the elution support 141. There is a gap between the first sealing joint 142 and the second sealing joint 143 for the detection card 9 to pass through.

[0050] like Figure 7 、 Figure 13 and Figure 16 As shown, the first tight joint 142 is installed on the eluting support 141 through the first connecting member 40 , and the second tight joint 143 is installed on the eluting support 141 through the second connecting member 50 .

[0051] like Figure 13 、 Figure 14 and Figure 15 As shown, the first connecting member 40 includes a first fixing block 41 and a first clamping block 42. The first fixing block 41 is fixed to the bottom surface of the elution bracket 141. The first clamping block 42 is installed on the bottom surface of the first fixing block 41. A transverse blind groove 46 is provided on the bottom surface of the first fixing block 41. The blind groove 46 is a structure with one end open and the other end closed. In this way, when the first clamping block 42 is installed in the blind groove 46, the inner end of the first clamping block 42 is stopped by the closed end of the blind groove 46. A first clamping hole 44 is provided in the middle of the first clamping block 42. A first slit 442 is provided below the first clamping hole 44 and communicates with the first clamping hole 44. A first bolt hole 445 is provided at the lower part of the first clamping block 42 and passes through the first slit 442. A first locking bolt 446 is provided in the first bolt hole 445. During assembly, the first sealing joint 142 is inserted into the first clamping hole 44, and the first locking bolt 446 is tightened to lock and fix the first sealing joint 142.

[0052] like Figure 14 and Figure 15 As shown, a quick-change mechanism 60 for conveniently replacing the first clamping block 42 is provided at the open end of the blind groove 46 .

[0053] The quick-change mechanism 60 includes a pressing block 61, a stop block 62 and a pin 63. An integrally formed mounting seat 64 is provided on the front side surface of the first fixed block 41 near the open end of the blind groove 46. The mounting seat has a transverse groove 641 and a horizontally arranged sliding hole 642 that passes through the transverse groove 641. The sliding hole 642 is in communication with the blind groove 46. The transverse groove 641 is a stepped groove with a step at the bottom. The pressing block 61 is inserted into the transverse groove 641, and there is a gap between the inner end surface of the horizontal portion 611 of the pressing block 61 and the side wall surface opposite to the notch of the transverse groove 641. The lower horizontal portion 611 of the pressing block 61 contacts the step. The stop block 62 is inserted into the sliding hole 642 and is located between the two horizontal portions 611 of the pressing block 61. A waist-shaped hole 621 is provided on the stop block 62. The waist-shaped hole 621 has a first position 622 and a second position 623. The two horizontal parts 611 of the pressing block 61 are symmetrically provided with pin holes 612. The pin 63 is located in the waist-shaped hole 621, and after the upper and lower ends respectively pass through the corresponding pin holes 612, the lower end is stopped by the step at the bottom of the transverse groove 641.

[0054] When the pin 63 is located in the first position of the waist-shaped hole 621, the inner end of the stop block 62 extends into the blind groove 46 to abut against the end of the first clamping block, and the outer end is located in the sliding hole 642. When the pressing block 61 is pressed, the pressing block 61 moves to force the pin 63 to move from the first position 622 to the second position 623. The outer end of the stop block 62 extends outward from the sliding hole 642, and the inner end retracts into the sliding hole 642. The inner end of the stop block 62 does not contact the first clamping block 42 and does not stop the first clamping block 42, so that the first clamping block 42 can be removed from the open end of the blind groove 46. This structure not only allows for convenient and quick removal of the first sealing joint 142, but also leaves sufficient space when replacing the second sealing joint 143, making it easier to replace the second sealing joint 143.

[0055] like Figure 7 and Figure 16 As shown, the second connecting member 50 includes a second fixing block 51 and a second clamping block 52. The second fixing block 51 is fixed to the bottom surface of the elution bracket 141. A longitudinal slide groove 55 is provided on the bottom surface of the second fixing block 51. The second clamping block 52 is slidably arranged in the longitudinal slide groove 55. A second clamping hole 53 is provided in the middle position of the second clamping block 52. A second slit 532 is provided below the second clamping hole 53 and communicates with the second clamping hole 53. A second bolt hole 533 is provided at the lower part of the second clamping block 52, passing through the second slit 532, and a second locking bolt 534 is provided in the second bolt hole 533. During assembly, the second tight joint 143 is installed in the second clamping hole 53, and the second locking bolt 534 is tightened to lock and fix the second tight joint 143.

[0056] A sealing joint driving motor 144 is fixed to the elution bracket 141 to drive the second sealing joint 143 to move toward the first sealing joint 142 .

[0057] Combine Figure 9 、 Figure 10 and Figure 11 As shown, a first flow channel 145 is provided in the first sealing joint 142, and a first cavity 1451 communicating with the first flow channel 145 is formed at the rear end. A second flow channel 146 is provided in the second sealing joint 143, and a second cavity 1461 communicating with the second flow channel 146 is formed at the front end. The first flow channel 145, the first cavity 1451, the second flow channel 146, and the second cavity 1461 are all coaxially arranged. The openings of the two cavities are the same size, and when the two cavities are close together, an elution cavity 147 is formed. With the above structure, the test card with the blood sample is transferred to the gap between the first sealing joint 142 and the second sealing joint 143. When the two cavities are close together, an elution cavity 147 is formed, and the blood sample on the test card is exactly located in the elution cavity 147. Subsequently, the eluent flows into the second flow channel, passes through the elution chamber, and flows out of the first flow channel, so that the blood sample is separated from the test card. This avoids the need in the prior art to first punch out the blood sample spot on the card test paper, then add a solvent to extract the sample, and after mixing and centrifugation to make a liquid sample, it is separated and analyzed by liquid chromatography-mass spectrometry, thereby greatly speeding up the detection process.

[0058] In this embodiment, the volume of first cavity 1451 is greater than that of second cavity 1461. First cavity 1451 is conical, while second cavity 1461 is flat. This structure allows the flat second cavity, with its smaller volume, to be quickly filled with eluent, ensuring sufficient contact between the eluent and the blood sample. The conical first cavity, with its larger volume, creates a pressure differential with the first cavity, promoting the penetration of the eluent and enhancing the fluidity of the liquid passing through the test card, making it easier for the blood sample to be removed from the test card.

[0059] like Figure 9 、 Figure 10 and Figure 11 As shown, an annular boss 147 is provided on the front end face of the second sealing joint 143. An annular recess 148 is provided on the rear end face of the first sealing joint 142 to match the boss 147. With this structure, the detection card 9 can be clamped more tightly and the sealing effect is good.

[0060] like Figure 17As shown, a drying system 30 and a heating element 32 are also mounted on the bottom plate 171. A delivery pump 7, a detection instrument 6, and a collection bottle 5 are also provided on the outside of the lower housing 11. The delivery pump 7, drying system 30, heating element 32, first sealing joint 142, second sealing joint 143, detection instrument 6, and collection bottle are all connected to a control line 8. Thus, the eluent is pneumatically delivered by the delivery pump 7. The eluent enters the elution chamber through the second flow channel to elute the blood sample on the test card 9. Afterwards, the eluent flows out of the first flow channel and enters the detection instrument 6 for testing. Subsequently, the waste liquid is switched by a switching valve 4 connected to the control line 8 and flows into the collection bottle 5. A flow valve 31 is also provided on the control line 8 to control the switching of the air or water path. A heating element heats the portion of the control line located behind the second flow channel, thereby heating the eluent flowing through it. This makes it easier for the eluent to elute the blood sample from the test card. Once the blood sample on the test card has been eluted, hot air generated by the drying system 30 is switched via the circulation valve 31. This hot air is blown into the second flow channel 145, through the elution chamber 147, and out of the first flow channel 146 into the collection bottle 5. The hot air dries the current test card 9, preventing excess eluent from remaining on the test card, allowing for the reuse of the test card. It also dries the control line and evacuates any remaining eluent.

[0061] The above is the fully automatic card-type blood sample collection device of the present invention. Its operation is as follows: During operation, the rotary motor drives the electric turntable 24 to rotate, transferring a magazine 22 as the current magazine 22 to the underside of the gripping mechanism 23. Subsequently, the gripper lifting assembly 234, the gripper longitudinal movement assembly 232, the gripper transverse movement assembly 236, and the gripper cylinder 237 cooperate to drive the gripper 238 to grasp the test card 9 containing the blood sample at the front of the magazine 22. At this point, the clamp 121, waiting in the first stop position, is detected by the third sensor 126, which transmits a signal to the controller. The controller then activates the drive motor 1233, driving the rear end of the U-shaped frame 1232 downward. When the first sensor 124 detects the rear end of the U-shaped frame 1232, the rear end of the U-shaped frame 1232 is in a low position, while the front end of the U-shaped frame 1232 rises and is in a high position, causing the drive motor 1233 to stop. Subsequently, the controller controls the clamp lifting assembly 234, the clamp longitudinal movement assembly 232 and the clamp transverse movement assembly 236 to cooperate with each other to insert the current detection card 9 from the outlet 211 and through the inlet 111 into the clamp 121. At the same time, the clamp cylinder 237 drives the clamp 238 to release the current detection card 9.

[0062] Subsequently, the drive motor 1233 drives the tail of the U-shaped frame 1232 to rise slightly, causing the front end of the U-shaped frame 1232 to drop slightly. After that, the detection camera 132 scans the current detection card 9. The detection camera 132 transmits the captured photo to the controller. After the controller intelligently identifies the position of the blood sample on the detection card 9 in the photo, the controller controls the clamp lifting assembly 123 and the clamp translation assembly 122 to cooperate, driving the clamp 121 to clamp the current detection card 9 and move it to the gap between the first sealing joint 142 and the second sealing joint 143, with the blood sample on the detection card 9 exactly located between the first cavity 1451 and the second cavity 1461. Subsequently, the sealing joint drive motor 144 drives the second sealing joint 143 to translate toward the first sealing joint 142 until it abuts against the first sealing joint 142, and the two cavities come together to form an elution cavity 147. Subsequently, through pneumatic delivery by the delivery pump, the eluent flows into the second flow channel 146, passes through the elution chamber 147, and flows out of the first flow channel 145, separating the blood sample from the test card. The eluent containing the blood sample flows into the detection instrument for detection. Subsequently, the switching valve 4 is switched to allow the waste liquid to flow into the collection bottle 5. After that, the circulation valve 31 controls the switching, and the hot air generated by the drying system is blown into the second flow channel 146, passes through the elution chamber 147, and flows out of the first flow channel 145 into the collection bottle, drying the current test card 9, drying the control line, and emptying the residual eluent.

[0063] Subsequently, the sealing joint drive motor 144 drives the second sealing joint 143 back to its initial position. The clamp lifting assembly 123 and the clamp translation assembly 122 cooperate to drive the clamp 121 to clamp the current test card 9 and move it below the inlet 111. Subsequently, the jaw lifting assembly 234, the jaw longitudinal movement assembly 232, the jaw transverse movement assembly 236, and the jaw cylinder 237 cooperate to drive the jaw 238 to clamp the current test card 9 and return it to the original compartment 221 of the magazine 22. The above steps are then repeated for the next test card 9 containing a blood sample. This cycle completes the continuous elution of test cards 9 containing blood samples one by one.

[0064] In summary, the present invention comprises a first flow channel within the first seal joint, forming a first cavity at the rear end that communicates with the first flow channel. A second flow channel is disposed within the second seal joint, forming a second cavity at the front end that communicates with the second flow channel. When the two cavities are brought together, they form an elution chamber. When a blood sample on the test card is located within the elution chamber, the eluent flows through the second flow channel, passes through the elution chamber, and exits the first flow channel, rapidly detaching the blood sample from the test card. This accelerates the testing process, while maintaining a simple structure and reducing costs.

[0065] The above is a detailed description of an embodiment of the present invention. However, the content described is only a preferred embodiment of the present invention and should not be considered to limit the scope of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. A fully automatic card-type blood sample extraction device, comprising an analysis module and a grabbing module disposed on the analysis module; an outlet is provided at the bottom of the grabbing module, and an inlet is provided at the top of the analysis module, communicating with the outlet, forming a detection card channel between the outlet and the inlet; characterized in that: The grabbing module includes an upper box body, a plurality of material boxes for storing test cards at the bottom position of the upper box body, and a grabbing mechanism for grabbing the test cards; the analysis module includes a lower box body, a bracket arranged in the lower box body, a test card conveying mechanism arranged on the bracket, a detection mechanism for detecting the position of the blood sample on the test card, an elution mechanism for eluting the blood sample from the test card with the blood sample, and a drying system for drying the test card after elution; the elution mechanism includes a first sealing joint and a second sealing joint arranged at the front and rear, and the first sealing joint is provided. There is a gap between the head and the second tight joint for the detection card to pass through. A tight joint driving motor is provided behind the second tight joint to drive the second tight joint to move toward the first tight joint. A first flow channel is provided in the first tight joint, and a first cavity communicating with the first flow channel is formed at the rear end. A second flow channel is provided in the second tight joint, and a second cavity communicating with the second flow channel is formed at the front end. The first flow channel, the first cavity, the second flow channel and the second cavity are all coaxially arranged, and the openings of the two cavities are the same size. When the two cavities are close together, an elution cavity is formed.

2. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: The volume of the first cavity is greater than that of the second cavity. The first cavity is conical, and the second cavity is flat.

3. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: It also includes a heating element installed in the lower box body. The drying system, heating element, first tight joint and second tight joint are connected through the same control pipeline. A flow valve for controlling switching is also connected to the control pipeline.

4. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: An electric turntable is provided at the bottom of the upper box body, and multiple material boxes are evenly spaced on the electric turntable. The gripping mechanism includes a clamp, a clamp lifting assembly for driving the clamp to lift and lower, a clamp longitudinal movement assembly for driving the clamp longitudinal translation, and a clamp transverse movement assembly for driving the clamp transverse translation.

5. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: The detection card conveying mechanism includes a clamp located below the inlet, a clamp translation component for driving the clamp to translate laterally, and a clamp lifting component for driving the clamp to move up and down.

6. The fully automatic card-type blood sample extraction device according to claim 5, characterized in that: The clamp lifting assembly comprises a U-shaped frame whose middle portion is hinged on a bracket and a driving motor located at the rear portion of the U-shaped frame for driving the tail portion of the U-shaped frame to lift and lower.

7. The fully automatic card-type blood sample extraction device according to claim 5, characterized in that: The clamp translation assembly includes a support base fixed to the front end of the U-shaped frame, a motor fixed on the support base and a pulley, two pulleys are fixed at both ends of the support base, and belts are provided on the two pulleys, one of the pulleys is connected to the motor through a rotating shaft, the clamp is fixedly connected to the belt, a plurality of guide wheels are provided on the support base, and the belt passes around all the guide wheels in turn, the clamp is located at the front end of the U-shaped frame and is fixedly connected to the belt, a transverse guide rail is fixed on the support base in front of the belt, a transverse slider is slidably connected to the transverse guide rail, and the clamp is fixed on the transverse slider.

8. The fully automatic card-type blood sample extraction device according to claim 1, characterized in that: The elution mechanism further includes an elution bracket, the first tight joint is installed on the elution bracket via a first connector, and the second tight joint is installed on the elution bracket via a second connector.

9. The fully automatic card-type blood sample extraction device according to claim 8, characterized in that: The first connecting member includes a first fixing block and a first clamping block. The first fixing block is fixed to the bottom surface of the elution bracket. The bottom surface of the first fixing block is provided with a transverse blind groove. The first clamping block is installed in the blind groove. The first clamping block is provided with a first clamping hole. The first sealing joint is installed in the first clamping hole.

10. The fully automatic card-type blood sample extraction device according to claim 8, characterized in that: The second connecting member includes a second fixed block and a second clamping block. The second fixed block is fixed to the bottom surface of the elution bracket and is located behind the first fixed block. The bottom surface of the second fixed block is provided with a longitudinal slide groove. The second clamping block is slidably arranged in the slide groove. The second clamping block is provided with a second clamping hole. The second sealing joint is installed in the second clamping hole.

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