Insecticidal composition containing pyrethroid compound and application thereof

Abstract

The invention belongs to the technical field of pesticides, and relates to an insecticidal composition containing pyrethroid compounds and application. The insecticidal composition comprises an active component A and an active component B, the active component A is a compound represented by a formula (I), and the active component B is a pyrethroid compound. The composition disclosed by the invention has a synergistic effect on prevention and control of agricultural and forestry pests within a certain proportioning range, is good in target fast-acting property and safe to crops, and can effectively reduce the dosage.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides, and particularly relates to an insecticide composition containing pyrethroid compounds and application thereof. Background Art

[0002] Pyrethroids are a class of highly effective, broad-spectrum insecticides that are widely used in agricultural pest control and public health. Pyrethroids are a class of insecticides with potent neurotoxicity, which mainly act on voltage-gated ion channels, can regulate the opening or closing of sodium ion channels, cause synaptic discharges, depolarization, and damage to the nervous system, especially have a relatively strong toxic effect on the peripheral nervous system and central nervous system.

[0003] Pyrethroid pesticides, with their high efficiency, wide range of action, strong stability and relatively low toxicity, have gradually replaced organochlorine and other highly toxic and long-residue insecticides and are widely used in agriculture, forestry and residential pest control. Pyrethroid insecticides have the fastest growth among the four major types of insecticides. While pyrethroids are widely used, they also have problems such as easy resistance, high fish toxicity, and low systemicity. At present, many pests and mites such as cotton bollworm, diamondback moth, whitefly, and two-spotted spider mite have developed above-medium resistance to pyrethroid insecticides.

[0004] Therefore, there is a continuing need for more effective, less costly, and environmentally safer insecticidal compositions. Summary of the invention

[0005] The purpose of the present invention is to provide an insecticidal composition containing pyrethroid compounds, wherein the insecticidal activity of the insecticidal composition of the present invention is significantly higher than the sum of the insecticidal activities of the individual active ingredients, and there is an unexpected, real synergistic effect, rather than just the sum of the effects.

[0006] To achieve the above object, the technical solution adopted by the present invention is: an insecticide composition containing pyrethroid compounds, comprising active ingredient A and active ingredient B, wherein the active ingredient A is a compound of formula (I) The active ingredient B is a pyrethroid compound;

[0007] Furthermore, the pyrethroid compounds include acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentylisomer, bioethanomethrin, biopermethrin (biopermethrin), bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, (RS) cyhalothrin, theta-cypermethrin methrin), cyphenothrin, deltamethrin, empenthrin (1-R isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate, flucythrinate flucythrinate), flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-,trans-), phenothrin (1R transisomer), prallethrin, profluthrin, protrifenbute, pyresmethrin, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (1R isomer), tralomethrin, transfluthrin, pyrethrins;

[0008] Further, the pyrethroid compounds include acralthrin, high-efficiency cyfluthrin, bifenthrin, cyfluthrin, high-efficiency trans-cypermethrin, cypermethrin, deltamethrin, cypermethrin, bromothrin, flucythrin, flucythrin, flumethrin, fluvalinate, bromothrin, high-efficiency cyhalothrin, ethynethrin, pyrethrin, tralomethrin, transfluthrin, pyrethrin;

[0009] Generally, the pesticidal composition of the present invention comprises the compound of formula (I) and the active ingredient B in the preferred, particularly preferred and especially preferred mixing ratios listed in the following table.

[0010] Component B Preferred mixing ratio Particularly preferred mixture Very particularly preferred mixing ratio Acrinathrin 1:100～100:1 1:40～30:1 1:40～25:1 Beta-cyfluthrin 1:40～60:1 1:25～60:1 1:12～15:1 Bifenthrin 1:30～80:1 1:30～45:1 1:14～45:1 Cyfluthrin 1:50～50:1 1:30～25:1 1:10～20:1 Highly effective trans-cypermethrin 1:45～45:1 1:35～35:1 1:15～15:1 Cypermethrin 1:50～50:1 1:40～20:1 1:30～18:1 Deltamethrin 1:50～24:1 1:30～24:1 1:18～12:1 Cypermethrin 1:50～50:1 1:25～25:1 1:15～25:1 Flumethrin 1:50～40:1 1:25～35:1 1:10～20:1 Flucythrinate 1:50～50:1 1:30～25:1 1:20～20:1 Bifenthrin 1:100～100:1 1:40～30:1 1:20～15:1 Fluvalinate 1:100～100:1 1:40～35:1 1:10～20:1 Bromofluthrin 1:50～30:1 1:25～25:1 1:25～25:1 Lambda-cyhalothrin 1:50～50:1 1:25～30:1 1:15～15:1 Permethrin 1:50～50:1 1:25～25:1 1:15～20:1 Pyrethrum 1:100～100:1 1:55～50:1 1:15～20:1 Trabromothrin 1:55～50:1 1:25～25:1 1:15～20:1 Transfluthrin 1:100～100:1 1:45～35:1 1:20～25:1 Pyrethrins 1:50～45:1 1:45～25:1 1:25～20:1

[0011] Furthermore, the pyrethroid compounds include high-efficiency cyfluthrin, bifenthrin, high-efficiency trans-cypermethrin, deltamethrin, and high-efficiency cyhalothrin;

[0012] Furthermore, the mass ratio between the active ingredient A and the active ingredient B is 1:50 to 80:1;

[0013] Furthermore, the mass ratio between the active ingredient A and the active ingredient B is 1:35 to 60:1;

[0014] Furthermore, the mass ratio of the compound of formula (I) to high-efficiency cyfluthrin is 1:40 to 60:1.

[0015] Further, the mass ratio of the compound of formula (I) to high-efficiency cyfluthrin is 1:25 to 60:1, such as 1:25, 1:12, 1:2, 5:1, 15:1, 40:1, 60:1 or any value between the above values;

[0016] Furthermore, the mass ratio of the compound of formula (I) to bifenthrin is 1:30 to 80:1.

[0017] Further, the mass ratio of the compound of formula (I) to bifenthrin is 1:30 to 45:1, such as 1:30, 1:14, 1:6, 10:1, 20:1, 45:1 or any value between the above values;

[0018] Further, the mass ratio of the compound of formula (I) to highly effective trans-cypermethrin is 1:35 to 35:1, such as 1:35, 1:28, 1:24, 1:15, 1:12, 1:6, 1:3, 2:5, 3:1, 5:1, 8:1, 15:1, 17:1, 25:1, 5:1 or any value between the above values;

[0019] Furthermore, the mass ratio of the compound of formula (I) to high-efficiency cyhalothrin is 1:25 to 60:1, 1:25, 1:15, 1:5, 1:1, 4:1, 15:1, 30:1, 60:1 or any value between the above values;

[0020] Furthermore, the mass ratio of the compound of formula (I) to deltamethrin is 1:50 to 24:1;

[0021] Further, the mass ratio of the compound of formula (I) to deltamethrin is 1:30 to 24:1, such as 1:30, 1:18, 1:9, 1:3, 12:1, 24:1 or any value between the above values;

[0022] Furthermore, based on the total mass of the insecticide composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 0.5% to 90%;

[0023] Furthermore, based on the total mass of the insecticide composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 5% to 70%;

[0024] Furthermore, based on the total mass of the insecticide composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 10% to 60%;

[0025] Furthermore, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 5%, 8%, 10%, 14%, 20%, 30%;

[0026] Furthermore, the insecticide composition also includes an adjuvant, and the adjuvant includes a carrier and an adjuvant;

[0027] Furthermore, the carrier is one or more of water, solvent or filler;

[0028] Furthermore, the carrier is deionized water;

[0029] Further, the solvent is selected from a mixture of one or more of N,N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;

[0030] Furthermore, the filler is selected from a mixture of one or more of kaolin, diatomaceous earth, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

[0031] The auxiliary agent includes at least one surfactant, and other functional auxiliary agents such as antifreeze, thickener, stabilizer, disintegrant, defoamer, sustained-release agent, binder, etc. may be added according to different usage occasions and requirements;

[0032] The surfactant is selected from one or more of an emulsifier, a dispersant, a wetting agent, a dispersion medium or a penetrant;

[0033] The above-mentioned surfactant is a single agent or a compound preparation of a common nonionic surfactant or anionic surfactant; the other functional additives are selected from one or more of antifreeze, thickener, stabilizer, disintegrant or defoamer;

[0034] Further, the emulsifier is selected from Nongru 500# (calcium alkylbenzene sulfonate), OP series phosphate ester (surfactant phosphate ester), 600# phosphate ester (phenylphenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether wetting agent salt, alkyl diphenyl ether disulfonic acid magnesium salt, triethanolamine salt, Nongru 400# (benzyl dimethylphenol polyoxyethyl ether), Nongru 700# (alkylphenol formaldehyde resin polyoxyethyl ether), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethyl ether), Nongru 1600# (phenylethylphenol polyoxyethyl polypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (surfactant), BY series (castor oil polyoxyethylene ether), Nongru 33# (alkylaryl polyoxyethylene polyoxypropylene ether), Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether) One or more of the mixture;

[0035] Further, the dispersant is selected from a mixture of one or more of polycarboxylates, lignin sulfonates, alkylphenol polyoxyethylene ether formaldehyde condensate sulfates, alkylbenzene sulfonate calcium, naphthalenesulfonic acid formaldehyde condensate sodium salts, alkylphenol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene ethers or glycerol fatty acid ester polyoxyethylene ethers;

[0036] Furthermore, the wetting agent is selected from a mixture of one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, lakai powder BX, wetting and penetrating agent F, sapodilla powder, silkworm feces or soapberry powder;

[0037] Furthermore, the penetrant is selected from a mixture of one or more of penetrant JFC (fatty alcohol polyoxyethylene ether), penetrant T (diisooctyl maleate sulfonate), azone or silicone;

[0038] Further, the dispersion medium is one or more of soybean oil, rapeseed oil, wheat oil, methyl oleate, diesel, motor oil, mineral oil, etc.;

[0039] Furthermore, the antifreeze agent is selected from a mixture of one or more of ethylene glycol, propylene glycol, glycerol or urea;

[0040] Furthermore, the thickener is selected from a mixture of one or more of xanthan gum, disintegrant, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;

[0041] Furthermore, the stabilizer is selected from a mixture of one or more of epoxy soybean oil, epichlorohydrin, BHT, ethyl acetate, and triphenyl phosphate;

[0042] Furthermore, the disintegrant is selected from a mixture of one or more of bentonite, urea, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;

[0043] Furthermore, the defoaming agent is selected from silicone oil, silicone compounds, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 A mixture of one or more fatty alcohol compounds.

[0044] Furthermore, the insecticidal composition can be formulated into pesticide-acceptable formulations, including solid formulations, liquid formulations, seed treatment agents or other formulations;

[0045] Furthermore, the formulation is in the form of emulsifiable concentrate, suspension, water dispersible granules, aqueous emulsion, microemulsion, granules, microcapsule suspension, ultra-low volume liquid, wettable powder or dispersible oil suspension;

[0046] Application of an insecticide composition containing pyrethroid compounds in preventing and controlling agricultural and forestry pests, horticultural pests or sanitary pests;

[0047] Furthermore, the agricultural and forestry pests, horticultural pests, and sanitary pests are pests of the orders Hemiptera, Thysanoptera, Lepidoptera, and Diptera;

[0048] Further, the Hemiptera pests are Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyllopus, Lygus lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubea insularis, Thyanta perditor, Acyrthosiphononobrychis, Adelges spp. laricis), Aphidula nasturtii, Beet aphid (Aphisfabae), Strawberry root aphid (Aphis forbesi), Apple aphid (Aphis pomi), Cotton aphid (Aphis gossypii), North American tea aphid (Aphis grossulariae), Schneider aphid (Aphis schneideri), Leaf roller aphid (Aphisspiraecola), Elder aphid (Aphis sambuci), Pea aphid (Acyrthosiphon pisum), Eggplant aphid (Aulacorthum solani), Silverleaf whitefly (Bemisia argentif olii), Flying short-tailed aphid (Brachycauduscardui), Plum short-tailed aphid (Brachycaudus helichrysi), Peach short-tailed aphid (Brachycaudus persicae), Brachycaudus prunicola, Cabbage aphid (Brevicoryne brassicae), Capitophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis sutchuenensis,radicola), Dysaulacorthumpseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, Myzodes persicae, Myzus ascalonicus, Myzuscerasi, Myzus varians, Nasonovia ribis-nigri, Nilaparvata lugens), Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mali, Psyllapiri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Trialeurodes vaporariorum, Toxoptera aurantiiand, Viteus vitifolii, Cimex lectularius, Cimex stink bug, hemipterus), Reduvius senilis, Triatoma and Arilus critatus;

[0049] Further, the Thysanoptera pests are orchid thrips (Dichromothripscorbetti), Dichromothrips spp., tobacco brown thrips (Frankliniella fusca), alfalfa flower thrips (Frankliniella occidentalis), oriental flower thrips (Frankliniella tritici), platycodon thrips (Scirtothrips citri), rice thrips (Thrips oryzae), palm thrips (Thrips palmi) and tobacco thrips (Thrips tabaci);

[0050] Further, the lepidopteran pests are Agrotis ypsilon, Agrotissegetum, Alabama argillacea, Anticarsia gemmatalis, Argyresthia conjugella, Autographa gamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheimatobia brumata, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diaphanianitidalis, Diatraea grandiosella, Earias insulana, Elasmopalpus occidentalis, lignosellus), Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Grapholitha molesta, Heliothis armigera, Heliothis virescens, Heliothis zea, Hellulaundalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeutamalinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygma exigua, Leucoptera coffeella, Leucopterascitella, Lithocolletis blancardella, Lobesia botrana), beet web borer (Loxostege sticticalis), gypsy moth (Lymantriadispar), Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestrabrassicae, Orgyia pseudotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridromasaucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae, Plathypena scabra, Plutella xylostella, Pseud oplusiaincludens, Rhyacionia frustrana, Scropipalpula absoluta, wheat moth (Sitotrogacerealella), grape leaf roller (Sparganothis pilleriana), fall armyworm (Spodopterafrugiperda), sea armyworm (Spodoptera littoralis), cutworm (Spodoptera litura), Thaumatopoea pityocampa, green oak moth (Tortrix viridana), powder looper (Trichoplusiani), and Zeiraphera canadensis;

[0051] Further, the Diptera) is Aedes aegypti, Aedes albopictus, Aedes vexans, Anastrepha ludens, Anopheles maculipennis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anopheles freeborni, Anopheles leucosphyrus, Anopheles miimus, Bradysia odoriphaga Yang et Zhang, Anopheles quadrimaculatus, Calliphora vicina, Ceratitis capitata, Chrysomyabezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Contarinia sorghicola, Cordylobia anthropophaga, Culicoides furens, Culex pipiens, Culex nigripalpus, Culex quinquefasciatus, Culex tarsalis, Culiseta inornata, Culisetamelanura, Dacus cucurbitae, Dacus oleae, Dasineurabrassicae, Delia antique, Delia coarctata, Delia platura, Delia rapa radicum), Dermatobia hominis, Fanniacanicularis, Geomyza Tripunctata, Gasterophilusintestinalis), Glossina morsitans, Glossina palpalis, Glossina fuscipes, Glossina tachinoides, Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Musca autumnalis, Musca domestica, Muscina stabulans, Oestrus ovis), Opomyza florum, Oscinella frit, Pegomyahysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sarcophaga haemorrhoidalis, Sarcophaga spp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, Tabanus similis, Tipula oleracea and European crane flies ( Tipula paludosa );

[0052] Furthermore, the insecticide composition is applied to the pests to be controlled or the medium in which they grow in an effective dose.

[0053] The insecticidal composition of the present invention has the following advantages:

[0054] The insecticide composition of the present invention exhibits a synergistic effect within a certain ratio range, is highly effective against agricultural and forestry pests, significantly reduces the amount of pesticides used, reduces the cost of pesticides, and reduces the impact on the environment; the two active ingredients have different action mechanisms and can delay the development of pest resistance. DETAILED DESCRIPTION

[0055] The present invention is further described below with reference to the examples. The percentages in the examples are all percentages by weight, but the present invention is not limited thereto.

[0056] The composition of the present invention can be provided in the form of a preparation. It can be prepared into an emulsifiable concentrate, a suspension, etc. as required. The content of the active ingredient in the composition of the present invention depends on the dosage when used alone, and also depends on the mixing ratio and the degree of synergistic effect. The optimal range of the active ingredient content varies according to the preparation type of the composition.

[0057] Preparation Example:

[0058] Example 1: 8% compound of formula (I)·high-efficiency cyfluthrin emulsifiable concentrate (3:5)

[0059] Formula composition: 3% compound of formula (I), 5% high-efficiency cypermethrin, 8% isomeric alcohol polyoxyethylene ether, 1% sodium wood sulfonate, 10% fatty alcohol polyoxyethylene ether, 4% soybean oil, 18% cyclohexanone, and methyl oleate makes up the balance;

[0060] Preparation method: firstly add the active ingredient into the solvent and completely dissolve it, then add the emulsifier and the like and stir evenly to form a uniform and transparent oily liquid, and then fill it to prepare the emulsifiable concentrate preparation of the composition of the present invention.

[0061] Example 2: 10% compound of formula (I)·bifenthrin emulsifiable concentrate (9:1)

[0062] Formula composition: 9% compound of formula (I), 1% bifenthrin, 10% DMF, 10% dimethyl sulfoxide, 20% capric amide, 2% calcium dodecylbenzene sulfonate, 14% fatty alcohol polyoxyethylene ether, 4% soybean oil, 10% cyclohexanone, and methyl oleate makes up the balance;

[0063] Preparation method: Same as Example 1.

[0064] Example 3: 14% compound of formula (I)·highly effective trans-cypermethrin emulsifiable concentrate (2:12)

[0065] Formula composition: 2% compound of formula (I), 12% highly effective trans-cypermethrin, 8.5% propylene carbonate, 15% fatty alcohol polyoxyethylene ether, 5% soybean oil, 2% calcium dodecylbenzene sulfonate, 20% cyclohexanone, and trimethylbenzene makes up the balance;

[0066] Preparation method: Same as Example 1.

[0067] Example 4: 10% compound of formula (I)·deltamethrin emulsifiable concentrate (2:8)

[0068] Formula composition: 2% compound of formula (I), 8% deltamethrin, 8% DMF, 2% propylene carbonate, 12% tristyrylphenol polyoxyethylene ether, 5% soybean oil, 15% cyclohexanone, 1% calcium dodecylbenzenesulfonate, and methyl oleate makes up the balance;

[0069] Preparation method: Same as Example 1.

[0070] Example 5: 5% compound of formula (I)·high-efficiency cyhalothrin emulsifiable concentrate (2.5:2.5)

[0071] Formula composition: 2.5% compound of formula (I), 2.5% highly effective chlorfenapyr, 6% isomeric alcohol polyoxyethylene ether, 1% calcium dodecylbenzene sulfonate, 10% fatty alcohol polyoxyethylene ether, 5% peanut oil, 12% cyclohexanone, 15% DMF, and methyl oleate makes up the balance;

[0072] Preparation method: Same as Example 1.

[0073] Example 6: 30% compound of formula (I)·high-efficiency cyfluthrin suspension (10:20)

[0074] Formula: 10% compound of formula (I), 20% highly effective cypermethrin, 1% fatty alcohol polyoxyethylene ether, 3% phenethylphenol polyether phosphate, 1% polycarboxylic acid sodium salt, 2.5% alkyl aryl polyoxyethylene polyoxypropylene ether, 1% magnesium aluminum silicate, 0.2% xanthan gum, 0.1% methylisothiazolinone, 5% glycerol, 0.4% organosilicon defoamer, and deionized water to make up the balance;

[0075] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in a reactor in sequence, water is added to mix evenly, and the suspension product is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0076] Example 7: 20% compound of formula (I)·highly effective trans-cypermethrin suspension (5:15)

[0077] Formula: 5% compound of formula (I), 15% highly effective trans-cypermethrin, 2% EO-PO block copolymer, 3% phenethylphenol polyether phosphate salt, 1% polycarboxylic acid sodium salt, 3% castor oil polyoxyethylene ether, 1% magnesium aluminum silicate, 0.2% xanthan gum, 0.1% methylisothiazolinone, 5% ethylene glycol, 0.4% organosilicon defoamer, and deionized water to make up the balance;

[0078] Preparation method: Same as Example 6.

[0079] The following biological test examples are used to illustrate the present invention. However, the present invention is not limited to these examples, and the reagents and solvents required for the test are provided by the group's research and development center.

[0080] Indoor biological activity assay

[0081] Determination of the combined toxicity of different ratios to aphids

[0082] Test target: Cotton aphid (Aphis gossypii Glover)

[0083] Select wingless adults raised indoors with consistent physiological status. Temperature (25±1)℃, relative humidity 65%±5%, photoperiod 16 / 8h (L / D);

[0084] Select healthy cucumber seedlings (4 leaves and one heart stage) with roots, carefully wash and dry the roots; insert the plant roots into a beaker containing the drug solution, provide light and normal conditions to ensure normal growth of the plant root system.

[0085] Drug preparation: Prepare single-dose stock solutions separately, and design the ratio according to the purpose of mixing and the activity of the drug. Each single dose and each group of mixed solutions shall be prepared into 5 series of mass concentrations in equal proportions, and the amount of drug solution for each mass concentration shall be no less than 50mL.

[0086] Chemical treatment: After 24 hours of continuous treatment, remove the plants from the solution, pick the second upper leaf of the same size, put it in a culture dish, and keep it moist for later use; place the culture dish on the bottom plate of the Potter spray tower for spraying, with a spray volume of 1 ml. After the solution has settled for 1 minute, take it out and transfer it to a culture dish containing leaves for breeding.

[0087] Each treatment was repeated 4 times, with 15 insects in each replicate. A treatment without pesticide was set as a blank control.

[0088] Data statistics and analysis:

[0089] 48 hours after treatment, check the mortality of the test insects and record the total number of insects and the number of dead insects. Calculate the corrected mortality rate of each treatment based on the survey data. Calculate according to the following formula:

[0090]

[0091] Where:

[0092] P——mortality rate, in percentage (%);

[0093] K——indicates the number of dead insects, in units of heads;

[0094] N——represents the total number of insects treated, in heads.

[0095]

[0096] Where:

[0097] P1——adjusted mortality rate, in percentage (%);

[0098] P t ——Treatment mortality rate, expressed as percentage (%);

[0099] P0——blank control mortality rate, in percentage (%).

[0100] If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be made according to the formula; if the control mortality rate is greater than 20%, the test needs to be repeated.

[0101] The data were processed using the probability value analysis method. The DPS statistical analysis system can be used to analyze and find the LC of the toxicity regression line. 50 The activity of the test agent on the biological test material was evaluated by using the b value and its 95% confidence limit, b value and correlation coefficient r.

[0102] The co-toxicity coefficient (CTC value) of the mixture is calculated as follows:

[0103]

[0104] Where:

[0105] ATI——Actual Toxicity Index of Mixture;

[0106] S——LC of standard pesticide 50 , the unit is milligrams per liter (mg / L);

[0107] M——LC of the mixture 50 , the unit is milligrams per liter (mg / L).

[0108] TTI=TI A *P A +TI B *P B

[0109] Where:

[0110] TTI – Theoretical Toxicity Index of Mixtures;

[0111] TI A ——A: toxicity index of the agent;

[0112] P A ——The percentage of agent A in the mixture, in percentage (%);

[0113] TI B ——Toxicity index of agent B;

[0114] P B ——The percentage of agent B in the mixture, in percentage (%).

[0115]

[0116] Where:

[0117] CTC – Co-toxicity coefficient;

[0118] ATI——Actual Toxicity Index of Mixture;

[0119] TTI - Theoretical Toxicity Index of Mixture.

[0120] The co-toxicity coefficient of the combination: CTC ≥ 120 shows a synergistic effect; CTC ≤ 80 shows an antagonistic effect; 80 < CTC < 120 shows an additive effect.

[0121] The results showed that the LC of the compound of formula (I) against aphids 50 79.204 mg·L -1 , the LC value of high-efficiency cyfluthrin against aphids 50 0.928 mg·L -1 , LC of bifenthrin against aphids 50 0.713 mg·L -1 , LC of highly effective trans-cypermethrin against aphids 50 5.433 mg·L -1 , the LC of cyhalothrin against aphids 50 1.376 mg·L -1 .

[0122] The results in Table 1 show that the compound of formula (I) and high-efficiency flucythrinate are mixed, and the combined effect of controlling aphids in the range of 1:40 to 60:1 shows an additive or synergistic effect; the combined effect of the compound of formula (I) and high-efficiency flucythrinate in the range of 1:25 to 60:1 shows a synergistic effect, and in the range of 1:12 to 15:1, the co-toxicity coefficient is greater than 200, showing a significant synergistic effect.

[0123] Table 1 Toxicity test results of different ratios of compound of formula (I) and high-efficiency cyfluthrin to aphids

[0124]

[0125] The results in Table 2 show that when the compound of formula (I) is mixed with bifenthrin, the combined effect of controlling aphids in the range of 1:30 to 80:1 shows an additive or synergistic effect; the combined effect of the compound of formula (I) and bifenthrin in the range of 1:30 to 45:1 shows a synergistic effect, and in the range of 1:14 to 45:1, a significant synergistic effect is shown.

[0126] Table 2 Toxicity test results of different ratios of compound of formula (I) and bifenthrin to aphids

[0127]

[0128] The results in Table 3 show that the compound of formula (I) and highly effective trans-cypermethrin are mixed, and the combined action for controlling aphids in the range of 1:28 to 35:1 shows a synergistic effect; and in the range of 1:15 to 8:1, a significant synergistic effect is shown.

[0129] Table 3 Toxicity test results of different ratios of the compound of formula (I) and highly effective trans-cypermethrin against aphids

[0130]

[0131]

[0132] The results in Table 4 show that when the compound of formula (I) is mixed with highly effective chlorfenapyr, the combined action against cotton bollworm in the range of 1:25 to 30:1 shows a synergistic effect; the co-toxicity coefficient of the combined action of the compound of formula (I) and highly effective chlorfenapyr in the range of 1:15 to 15:1 against cotton bollworm is greater than 180, showing a significant synergistic effect.

[0133] Table 4 Toxicity test results of different ratios of compound of formula (I) and cyhalothrin against aphids

[0134]

[0135] Determination of the combined toxicity of different ratios to cotton bollworm

[0136] Test target: Cotton bollworm. The larvae of cotton bollworm were collected from cotton fields in Tai'an, Shandong Province. They were artificially raised in an insect breeding room for more than three generations. Healthy, uniform and uniform third-instar larvae were selected for the test.

[0137] Test reference: "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides" Part 6: Insecticide Activity Test - Insect Immersion Method NY / T 1154.6-2006;

[0138] Drug preparation: Prepare the single-dose stock solution separately, and design the ratio according to the mixing purpose and the activity of the drug. Each single dose and each group of mixed doses are prepared into 5 series of mass concentrations in equal proportions.

[0139] Chemical treatment: Use tweezers to gently pick up the test insects and immerse them in the chemical solution for 5 seconds. After taking them out, place them on absorbent paper and let them crawl freely. After drying them slightly, move them into a culture dish with artificial feed for breeding. The breeding temperature is 29±1℃ and the photoperiod is 14 / 10h (L / D).

[0140] Each treatment was repeated 4 times, with 15 insects in each replicate. A treatment without pesticide was set as a blank control.

[0141] Data statistics and analysis:

[0142] 48 hours after treatment, check the mortality of the test insects and record the total number of insects and the number of dead insects. Calculate the corrected mortality rate of each treatment based on the survey data. Calculate according to the following formula:

[0143]

[0144] Where:

[0145] P——mortality rate, in percentage (%);

[0146] K——indicates the number of dead insects, in units of heads;

[0147] N——represents the total number of insects treated, in heads.

[0148]

[0149] Where:

[0150] P1——adjusted mortality rate, in percentage (%);

[0151] P t ——Treatment mortality rate, expressed as percentage (%);

[0152] P0——blank control mortality rate, in percentage (%).

[0153] If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be made according to the formula; if the control mortality rate is greater than 20%, the test needs to be repeated.

[0154] The data were processed using the probability value analysis method. The DPS statistical analysis system can be used to analyze and find the LC of the toxicity regression line. 50 The activity of the test agent on the biological test material was evaluated by using the b value and its 95% confidence limit, b value and correlation coefficient r.

[0155] The co-toxicity coefficient (CTC value) of the mixture is calculated as follows:

[0156]

[0157] Where:

[0158] ATI——Actual Toxicity Index of Mixture;

[0159] S——LC of standard pesticide 50 , the unit is milligrams per liter (mg / L);

[0160] M——LC of the mixture 50 , the unit is milligrams per liter (mg / L).

[0161] TTI=TI A *P A +TI B *P B

[0162] Where:

[0163] TTI – Theoretical Toxicity Index of Mixtures;

[0164] TI A ——A: toxicity index of the agent;

[0165] P A ——The percentage of agent A in the mixture, in percentage (%);

[0166] TI B ——Toxicity index of agent B;

[0167] P B ——The percentage of agent B in the mixture, in percentage (%).

[0168]

[0169] Where:

[0170] CTC – Co-toxicity coefficient;

[0171] ATI——Actual Toxicity Index of Mixture;

[0172] TTI - Theoretical Toxicity Index of Mixture.

[0173] The co-toxicity coefficient of the combination: CTC ≥ 120 shows a synergistic effect; CTC ≤ 80 shows an antagonistic effect; 80 < CTC < 120 shows an additive effect.

[0174] The results showed that the LC of the compound of formula (I) against cotton bollworm 50 0.855mg·L -1The results in Table 5 show that the compound of formula (I) and highly effective trans-cypermethrin are mixed, and the combined action in the range of 1:35 to 25:1 to control cotton bollworm shows a synergistic effect; among them, the co-toxicity coefficient of the combined action of the compound of formula (I) and highly effective trans-cypermethrin in the range of 1:24 to 15:1 to control cotton bollworm is greater than 160, showing a significant synergistic effect.

[0175] Table 5 Toxicity test results of different ratios of the compound of formula (I) and highly effective trans-cypermethrin against cotton bollworm

[0176]

[0177] The results in Table 6 show that the compound of formula (I) is mixed with deltamethrin, and the combined effect of controlling cotton bollworm in the range of 1:50 to 24:1 shows an additive or synergistic effect; among them, the combined effect of the compound of formula (I) and deltamethrin in the range of 1:30 to 24:1 shows a synergistic effect; in the range of 1:18 to 12:1, the co-toxicity coefficient is greater than 140, showing a significant synergistic effect.

[0178] Table 6 Toxicity test results of different ratios of the compound of formula (I) and deltamethrin to cotton bollworm

[0179]

[0180] Field efficacy examples

[0181] Experiment on the efficacy of different pesticides in controlling cucumber aphids

[0182] Experimental time and location: June 2023, vegetable planting base of Haidu College, Laiyang City, Shandong Province;

[0183] Tested crops: cucumber, variety: Jinyou No. 5; Control target: cucumber aphids;

[0184] Experimental field: The management level of the experimental field is average, the soil fertility is consistent, and the previous crop was potato; no other pesticides were used during the experiment.

[0185] Plot setting: Each treatment plot has an area of ​​30m 2 , set 4 repetitions, and arrange the cultivation conditions of all experimental plots in random blocks to be uniform;

[0186] Test method: Spray treatment was carried out at the early stage of cucumber aphid outbreak. A backpack sprayer was used to spray the pesticide evenly. The spraying was required to be uniform and consistent. The use capacity was about 450L / hm 2 .

[0187] Survey: Investigate the insect population base before applying the pesticide, and investigate once on the 3rd and 7th days after applying the pesticide, for a total of 3 times. Take samples at 5 points in each plot, and investigate the number of live aphids on at least 10 marked plants.

[0188] Treatment:

[0189] Table 7 Treatment and dosage of drugs

[0190]

[0191]

[0192] Calculation method of drug efficacy:

[0193]

[0194] Test results:

[0195] Field efficacy tests showed that, as described in Tables 8 and 9, the compound of formula (I) mixed with highly effective flucythrinate, bifenthrin, highly effective trans-cypermethrin, and highly effective cyhalothrin had good control effects on cucumber aphids. The field test results in Table 8 showed that the control effects of the mixed test agents reached more than 87% after 2 days of application, showing good rapidity. The control effects were ranked from high to low as follows: 14% compound of formula (I)·highly effective trans-cypermethrin emulsifiable concentrate (2:12), 5% compound of formula (I)·highly effective cyhalothrin emulsifiable concentrate (2.5:2.5), 8% compound of formula (I)·highly effective flucythrinate emulsifiable concentrate (3:5), and 10% compound of formula (I)·bifenthrin emulsifiable concentrate (9:1).

[0196] Table 8 Field test of each treatment against aphids

[0197]

[0198] Note: The above data are the average of 4 repetitions, and the values ​​are rounded to two decimal places.

[0199] The field test results in Table 9 show that the control effect of the mixed test agents continued to increase 7 days after application, showing good persistence. The control effects were as follows from high to low: 8% compound of formula (I)·high-efficiency flucythrinate emulsifiable concentrate (3:5), 10% compound of formula (I)·bifenthrin emulsifiable concentrate (9:1), 5% compound of formula (I)·high-efficiency chlorflucythrinate emulsifiable concentrate (2.5:2.5), and 14% compound of formula (I)·high-efficiency trans-cypermethrin emulsifiable concentrate (2:12).

[0200] Table 9 Field efficacy test of each treatment against aphids

[0201]

[0202] Note: The above data are the average of 4 repetitions, and the values ​​are rounded to two decimal places.

[0203] Experiment on the efficacy of different pesticides in controlling cotton bollworm

[0204] Test time and location: August 2022, cotton planting base in Jinxiang County, Jining;

[0205] Test crop: cotton (Chuangmian No. 3); Control target: cotton bollworm;

[0206] Experimental field: planting density 667m 2 / 1500 plants; Plot setting: Each treatment plot area is 20m 2 , set 4 times of replication, and the cultivation conditions of all experimental plots were uniform;

[0207] Test method: ground spray method;

[0208] Survey: Investigate the insect population base before applying the pesticide, and investigate the number of live insects 3d and 7d after applying the pesticide. In each plot, select the middle 2 rows to investigate the number of cotton bollworms and mark them with signs.

[0209] Treatment:

[0210] Table 10: Treatment and dosage of drugs

[0211]

[0212]

[0213] Calculation method of drug efficacy:

[0214]

[0215] Test results:

[0216] Field efficacy tests showed that, as shown in Table 11, the compound of formula (I) mixed with highly effective trans-cypermethrin and deltamethrin had a good control effect on cotton bollworm.

[0217] Table 11 Field efficacy test of each treatment against cotton bollworm

[0218]

[0219] Note: The above data are the average of 4 repetitions, the values ​​are rounded to two decimal places, and letters indicate significant differences (0.05 / DMRT method).

[0220] The insecticide composition or the preparation obtained by compounding the present invention has significant control effect, and is superior to a single agent in delaying the generation of drug resistance and prolonging drug retention. In addition, no compound agent was found to cause phytotoxicity to crops in the test, indicating that the insecticide composition or preparation obtained can reduce production costs and use costs and is safe for crops when the insecticide synergistic synergy is improved.

[0221] Although the present invention has been described in detail above with general instructions and specific implementation schemes, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. An insecticidal composition containing a pyrethroid compound, characterized in that: The active ingredient A and the active ingredient B are included, wherein the active ingredient A is a compound of formula (I) The active ingredient B is a pyrethroid compound.

2. The insecticidal composition according to claim 1, characterized in that: The pyrethroid compounds include acralthrin, high-efficiency cyfluthrin, bifenthrin, cyfluthrin, high-efficiency trans-cypermethrin, cypermethrin, deltamethrin, cypermethrin, bromothrin, flucythrin, flucythrin, fluvalinate, bromothrin, high-efficiency cyhalothrin, ethynethrin, pyrethrin, tralomethrin, transfluthrin, and pyrethrin; Preferably, the pyrethroid compounds include high-efficiency cyfluthrin, bifenthrin, high-efficiency trans-cypermethrin, deltamethrin, and high-efficiency cyhalothrin.

3. The insecticidal composition according to claim 1, characterized in that: The mass ratio between the active ingredient A and the active ingredient B is 1:50 to 80:1; Preferably, the mass ratio between the active ingredient A and the active ingredient B is 1:35 to 60:

1.

4. The insecticidal composition according to claim 1, characterized in that: Based on the total mass of the insecticide composition being 100wt%, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 0.5% to 90%.

5. The insecticidal composition according to claim 1, characterized in that: The insecticide composition also includes an adjuvant, which includes a carrier and an adjuvant.

6. The insecticidal composition according to claim 1, characterized in that: The insecticide composition can be formulated into pesticide acceptable formulations, including solid formulations and liquid formulations.

7. The insecticidal composition according to claim 6, characterized in that: The preparation dosage form is emulsifiable concentrate, suspension, water dispersible granule, aqueous emulsion, microemulsion, granule, microcapsule suspension, ultra-low volume liquid, wettable powder or dispersible oil suspension.

8. Use of the insecticidal composition according to any one of claims 1 to 7 in preventing and controlling agricultural and forestry pests, horticultural pests or sanitary pests.

9. The use according to claim 8, characterized in that: The agricultural and forestry pests, horticultural pests and sanitary pests are pests of the orders Hemiptera, Thysanoptera, Lepidoptera and Diptera.

10. The use according to claim 8, characterized in that: The insecticide composition is applied to the pests to be controlled or the medium where they grow in an effective dose.

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