Temperature-triggered burn dressing and preparation method thereof

Abstract

The invention relates to a temperature-triggered burn dressing. The temperature-triggered burn dressing comprises first release paper, second release paper, flash non-woven fabric, PVA-PNIPAM hydrogel, ammonium nitrate powder, a sodium alginate carrier, a first carrier, a second carrier and a third carrier, a fixing area is formed in the center of the top face of the flash evaporation non-woven fabric, adhesion areas are formed in other positions of the top face of the flash evaporation non-woven fabric, the bottom face of the sodium alginate carrier is fixed to the fixing area, the sodium alginate carrier comprises a first carrier body, a second carrier body and a third carrier body, and the first carrier body and the second carrier body are fixed to the bottom face of the flash evaporation non-woven fabric. The bottom face of the first carrier is fixed to the fixing area, the bottom face of the second carrier is fixed to the top face of the first carrier, the ammonium nitrate powder is smeared on the portion between the first carrier and the second carrier, and the bottom face of the third carrier is fixed to the fixing area. The medical dressing can be stored at normal temperature, and after the medical dressing is in contact with a wound, the interior of the medical dressing is refrigerated through warm contact, so that the wound is rapidly cooled.

Description

Technical Field

[0001] The invention relates to a medical dressing, belongs to the field of burn dressings, and in particular to a temperature-triggered burn dressing and a preparation method thereof. Background Art

[0002] Burns and scalds are accidental injuries that we easily encounter in life, such as scalds from boiling water and kitchen fire. After a burn or scald occurs, the damage does not stop immediately after moving away from the heat source. The residual heat on the skin tissue will further damage the wound and deepen the degree of injury. Therefore, the first thing to do after a burn or scald is to quickly reduce the skin surface temperature and remove the residual heat. Burn dressings are medical products used to manage and treat burn wounds. Their main functions are to protect the wound, promote healing, reduce the risk of infection and relieve pain.

[0003] The Chinese patent application with application number 202110530354.7 and application date May 4, 2021 discloses a hydrogel dressing for first aid and treatment of burn wounds. Specifically, the invention provides the use of the hydrogel dressing, i.e., for preparing a medical care product for first aid treatment of burn wounds or wounds. However, the technology has the following defects:

[0004] In the comparative documents, the dressing can be carried around and is easy to store. In emergency situations such as burns, the hydrogel can be brought into contact with the wound to absorb the heat from the wound, reduce the temperature of the wound and promote wound healing. In the specific use process, the temperature of the hydrogel itself is basically maintained at room temperature, but the temperature of the wound is limited by the release of water by the hydrogel when heated to absorb heat from the wound, which only reduces the temperature by 4-7°C. It is difficult to maintain the temperature of the wound in a suitable range below room temperature, because the residual heat at the wound cannot be contained, and the residual heat will continue to damage the burn wound tissue. In order to ensure the cooling effect and contain the damage to the burn wound tissue by the residual heat, the temperature of the dressing itself needs to be kept below room temperature for a long time to maintain the low temperature of the dressing. This method will not only limit the use of the dressing, but also easily cause waste of resources and increase costs.

[0005] The information disclosed in this background technology section is only intended to increase the understanding of the overall background of the application, and should not be regarded as acknowledging or suggesting in any form that the information constitutes the prior art already known to ordinary technicians in this field. Summary of the invention

[0006] The purpose of the present invention is to overcome the problem in the prior art that the temperature of the wound cannot be rapidly reduced after the dressing absorbs heat through warm touch, and to provide a temperature-triggered burn dressing and a preparation method thereof that can rapidly reduce the temperature of the wound after warm touch absorption.

[0007] To achieve the above objectives, the technical solution of the present invention is: a temperature-triggered burn dressing, the temperature-triggered burn dressing comprising: a first release paper, a second release paper, a flash-steamed nonwoven fabric, a PVA-PNIPAM hydrogel, ammonium nitrate powder, a sodium alginate carrier, a first carrier, a second carrier and a third carrier;

[0008] A fixed area is formed at a central position on the top surface of the flash steamed nonwoven fabric, and an adhesive area is formed at other positions on the top surface of the flash steamed nonwoven fabric. The bottom surface of the sodium alginate carrier is fixed at the fixed area. The sodium alginate carrier includes a first carrier, a second carrier and a third carrier. The bottom surface of the first carrier is fixed at the fixed area, and the bottom surface of the second carrier is fixed to the top surface of the first carrier. The ammonium nitrate powder is applied to a position between the first carrier and the second carrier, and the bottom surface of the third carrier is fixed at the fixed area. The outer side of the first carrier is fixed to a position on the inner wall of the third carrier close to its lower end surface, and the outer side of the second carrier is fixed to the inner wall of the third carrier close to its lower end surface. At the end surface, a placement area located at the inner upper side of the third carrier is formed on the top surface of the second carrier, the PVA-PNIPAM hydrogel is fixed in the placement area, the bottom surface of the PVA-PNIPAM hydrogel is adhered to the top surface of the second carrier, the periphery of the PVA-PNIPAM hydrogel is adhered to the inner wall of the third carrier, the PVA-PNIPAM hydrogel, the second carrier, ammonium nitrate powder, the first carrier and the flash-steamed non-woven fabric are distributed in sequence from top to bottom, the adhesion area is adhered with glue, the bottom surface of the first release paper is attached to the top surface of the glue, and the bottom surface of the second release paper is attached to the top surface of the PVA-PNIPAM hydrogel.

[0009] In the step S2, the length, width and height of the first carrier are 10 cm, 10 cm and 0.2 cm respectively, the length, width and height of the first carrier are 10 cm, 10 cm and 0.2 cm respectively, the first carrier and the second carrier have the same size, and the length, width and height of the placement area are 10 cm, 10 cm and 0.2 cm respectively.

[0010] The length, width and height of the PVA-PNIPAM hydrogel are 10 cm, 10 cm and 0.2 cm respectively, and the size of the PVA-PNIPAM hydrogel is compatible with the size of the placement area.

[0011] The length and width of the flash-steamed nonwoven fabric are both 14 cm, and the width (d) of the adhesive area is 2 cm.

[0012] A method for preparing a temperature-triggered burn dressing, the method comprising the following steps:

[0013] S1, first put 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water into a container, then use a heating device to continuously heat and stir the container, the polyvinyl alcohol and the deionized water at 90° C., and after stirring until the polyvinyl alcohol in the container is completely dissolved, cool it to room temperature to obtain a polyvinyl alcohol solution;

[0014] S2, then adding 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of ammonium persulfate and 18-27 parts by weight of N-isopropylacrylamide into the cooled polyvinyl alcohol solution in sequence, mixing and stirring, and stirring the polyvinyl alcohol solution until the N-isopropylacrylamide is completely dissolved to obtain a preliminary mixed solution;

[0015] S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added into the preliminary mixed solution, and the mixture is stirred for five minutes under ventilation to obtain a final mixed solution;

[0016] S4, then injecting the final mixed solution into a sealed molding mold for packaging, and placing the mold in an environment of 8° C. for 24 hours, and finally obtaining the PVA-PNIPAM hydrogel;

[0017] S5, first apply 50-100 parts by weight of ammonium nitrate powder on the surface of the first carrier to obtain a starting carrier, then apply environmentally friendly wood glue on the edge of the surface, and then cover the second carrier on the first carrier to cover the surface to form a preliminary carrier;

[0018] S6, then apply environmentally friendly wood glue on the periphery of the preliminary carrier, and put it into the third carrier, and after the environmentally friendly wood glue is air-dried, the first carrier, the second carrier and the third carrier form a sodium alginate carrier;

[0019] S7, firstly, the PVA-PNIPAM hydrogel obtained according to step S4 is adhered to the placement area of ​​the sodium alginate carrier according to its own viscosity to obtain an initial dressing;

[0020] S8. The initial dressing is fixed on the fixed area of ​​the flash nonwoven fabric by environmentally friendly wood glue, and then adhesive is applied to the sticky area of ​​the flash nonwoven fabric, and the first release paper is attached to the adhesive and the second release paper is attached to the PVA-PNIPAM hydrogel, respectively, to finally obtain the final dressing.

[0021] The amount of the polyvinyl alcohol is 10 parts by weight, the amount of the deionized water is 90 parts by weight, the amount of the N,N-methylenebisacrylamide is 0.0616 parts by weight, the amount of the ammonium persulfate is 0.3 parts by weight, the amount of the N-isopropylacrylamide is 18 parts by weight, the amount of the tetramethylethylenediamine is 0.0002 parts by weight, and the amount of the ammonium nitrate powder is 90 parts by weight.

[0022] In the step S1, the parameter of the heating and stirring is 500-600r / min, in the step S2, the parameter of the mixing and stirring is 500-600r / min, in the step S3, the parameter of the ventilation and stirring is 500-600r / min, in the step S1, the heating and stirring time is greater than 2h, and in the step S2, the mixing and stirring time is greater than 30min.

[0023] In step S5, the starting vector is obtained according to the following steps:

[0024] Step 1: first, lay the first carrier flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder and sprinkle it on the surface of the first carrier;

[0025] Step 2: Take another clean cotton swab, and then use the cotton swab to evenly spread the ammonium nitrate powder that has fallen on the first carrier above onto the surface of the first carrier, allowing the ammonium nitrate powder to adhere to the fiber fluff on the surface of the first carrier to obtain a starting carrier.

[0026] In step S6, the sodium alginate carrier is obtained according to the following steps:

[0027] Step 1: First, select a sodium alginate block with the dimensions of 10.2 cm in length, 10.2 cm in width and 0.6 cm in height, and then cut a square hole on the sodium alginate block according to the length and width of the first carrier and the second carrier to obtain a third carrier with a hollow interior;

[0028] Step 2: first apply environmentally friendly wood glue on the periphery of the preliminary carrier, then move the preliminary carrier into the third carrier obtained in the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier. After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier can form a sodium alginate carrier.

[0029] In step S8, the final dressing is obtained according to the following steps:

[0030] Step 1: Apply adhesive to the sticky area on the flash nonwoven fabric;

[0031] Step 2: Prepare a first release paper of the same size as the flash nonwoven fabric, and then cut a perforation of corresponding size at the center of the first release paper according to the length and width of the sodium alginate carrier, and then let the first release paper pass through the sodium alginate carrier through the perforation and adhere to the adhesive part on the adhesive area to completely cover the adhesive part;

[0032] Step 3: First prepare a second release paper of the same size as the sodium alginate carrier, and then attach the second release paper to the PVA-PNIPAM hydrogel based on the second step, so that the second release paper completely covers the PVA-PNIPAM hydrogel and the sodium alginate carrier, and finally obtain the final dressing.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] 1. In a temperature-triggered burn dressing and a preparation method of the present invention, the temperature-triggered burn dressing comprises: a first release paper, a second release paper, a flash nonwoven fabric, a PVA-PNIPAM hydrogel, ammonium nitrate powder, a sodium alginate carrier, a first carrier, a second carrier and a third carrier, wherein the sodium alginate carrier comprises a first carrier, a second carrier and a third carrier, the bottom surface of the first carrier is fixed at a fixed area, the bottom surface of the second carrier is fixed at a top surface of the first carrier, the ammonium nitrate powder is applied to a portion between the first carrier and the second carrier, and when applied, the PVA-PNIPAM hydrogel first contacts the wound, and when the temperature at the wound is higher than the critical dissolution temperature of the PVA-PNIPAM hydrogel, the PVA-PNIPAM hydrogel will release water to absorb heat, and then the released water will absorb heat. Therefore, the PVA-PNIPAM hydrogel will not release water and react with ammonium nitrate to absorb heat before the contact temperature reaches its critical dissolution temperature. This feature allows the dressing to be stored at room temperature. At the same time, during the heat absorption process, the heat at the wound is transferred to the dressing under the dual heat absorption of PVA-PNIPAM hydrogel and ammonium nitrate powder, and the temperature at the wound drops rapidly, so that the temperature at the wound is maintained at 10-15°C within 30min-60min, thereby cooling the wound, avoiding deepening the degree of damage to the burn wound tissue, curbing the degree of damage to the burn wound tissue, and allowing the dressing to effectively cool without keeping low temperature for a long time. Therefore, this design can be stored at room temperature, and after contacting the wound, the temperature of the wound instantly triggers its internal refrigeration reaction to quickly cool the wound.

[0035] 2. In a temperature-triggered burn dressing and preparation method of the present invention, a fixed area is formed at the central position on the top surface of the flash nonwoven fabric, and an adhesive area is formed at other positions on the top surface of the flash nonwoven fabric. The bottom surface of the sodium alginate carrier is fixed at the fixed area. When used, the flash nonwoven fabric can maintain its excellent water resistance during use due to its good liquid resistance. At the same time, because the flash nonwoven fabric has the material advantages of small fiber diameter and high monofilament strength, microorganisms must pass through the narrow and tortuous channels formed between multiple layers of stacked ultrafine fibers to penetrate the flash nonwoven fabric, so that the flash nonwoven fabric has a natural high microbial barrier. Therefore, the outer layer of the dressing made of the flash nonwoven fabric is not easily eroded by bacteria and other microorganisms, and can keep the inside of the dressing and the wound clean to a certain extent. Therefore, the protection and antibacterial properties of the design are good, and it has the advantages of protecting the wound from external pollution and delaying wound inflammation.

[0036] 3. In a temperature-triggered burn dressing and preparation method of the present invention, the length and width of the flash nonwoven fabric are both 14 cm, the width (d) of the adhesive zone is 2 cm, the adhesive zone is adhered with an adhesive, the bottom surface of the first release paper is attached to the top surface of the adhesive, the length, width and height of the PVA-PNIPAM hydrogel are 10 cm, 10 cm and 0.2 cm respectively. When applied, after a single piece of dressing is covered on the wound, the flash nonwoven fabric is adhered to the intact skin area at the edge of the wound through the 2 cm wide adhesive on the adhesive zone, which can effectively fix the dressing and improve the dressing when fixed. At the same time, when a single dressing cannot completely cover the wound, multiple dressings are arranged and combined together, and the sticky areas of the flash nonwoven fabrics in the overlapping state between adjacent dressings are adhered together by adhesives, so that multiple dressings can be spliced ​​together. The multiple dressings combined together can allow multiple PVA-PNIPAM hydrogels to cover a large area of ​​the wound. The 2-cm-wide sticky area and the adhesive thereon can not only make the dressing firmly connected to the skin, but also make multiple dressings firmly when spliced ​​and combined. Therefore, this design is firmly connected to the skin, and at the same time, multiple dressings can be combined to adapt to large-area wounds to completely cover the wound.

[0037] 4. A temperature-triggered burn dressing and preparation method of the present invention, the preparation method comprises: S1, heating polyvinyl alcohol and deionized water and stirring to obtain a polyvinyl alcohol solution; S2, sequentially adding N,N-methylenebisacrylamide, ammonium persulfate and N-isopropylacrylamide to the polyvinyl alcohol solution and mixing and stirring to obtain a preliminary mixed solution; S3, adding tetramethylethylenediamine to the preliminary mixed solution, and introducing nitrogen to obtain a final mixed solution; S4, casting the final mixed solution into a mold to finally obtain a PVA-PNIPAM hydrogel; S5, applying ammonium nitrate powder between a first carrier and a second carrier, and combining to obtain a preliminary carrier; S6, the first carrier, the second carrier and the third carrier form a hydrogel; Sodium alginate carrier; S7, fix the PVA-PNIPAM hydrogel in the sodium alginate carrier to obtain a preliminary carrier; S8, fix the preliminary carrier on the flash non-woven fabric to obtain the final carrier. When used, the dressing is prepared in the above order, which is not only easy to operate, but also does not require complicated equipment. The steps are simple and easy to perform, suitable for large-scale production, and the production cost is low, with obvious economic benefits. At the same time, the dressing prepared by the above steps can be immediately cooled and cooled after contacting a temperature higher than the critical dissolution temperature of the PVA-PNIPAM hydrogel, and the cooling effect is good. There is no need to keep the dressing at a low temperature for a long time to effectively cool it. Therefore, the design has the advantages of low production cost, simple preparation and good use effect.

[0038] 5. In a temperature-triggered burn dressing and preparation method of the present invention, 10 parts by weight of polyvinyl alcohol, 90 parts by weight of deionized water, 0.0616 parts by weight of N,N-methylenebisacrylamide, 0.3 parts by weight of ammonium persulfate, 18 parts by weight of N-isopropylacrylamide and 0.0002 parts by weight of tetramethylethylenediamine are prepared according to steps S1 to S4 to obtain PVA-PNIPAM hydrogel; S5, firstly smear 90 parts by weight of ammonium nitrate powder between the first carrier and the second carrier to form a preliminary carrier; PVA- PNIPAM hydrogel adheres to the preliminary carrier. When used, PVA-PNIPAM hydrogel absorbs heat when in contact with the wound. After absorbing heat, PVA-PNIPAM hydrogel releases 15 ml of water. 15 ml of water absorbs heat when reacting with 90 parts by weight of ammonium nitrate powder, which can maintain the temperature of the wound at 10-15°C within 30min-60min, thereby avoiding further damage to the burn wound tissue. Therefore, this design has good heat absorption and cooling effect and long maintenance time, which can effectively curb the further damage to the burn wound tissue. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 The present invention is a front view of a temperature-triggered burn dressing.

[0040] Figure 2It is a schematic diagram of the internal structure of a sodium alginate carrier in a temperature-triggered burn dressing of the present invention.

[0041] Figure 3 It is a schematic diagram of the separation structure of the sodium alginate carrier and the flash-steamed nonwoven fabric in a temperature-triggered burn dressing of the present invention.

[0042] Figure 4 It is a schematic diagram of the network structure of PVA-PNIPAM hydrogel in a temperature-triggered burn dressing of the present invention.

[0043] Figure 5 It is a schematic diagram of the surface structure of the first carrier in a temperature-triggered burn dressing of the present invention.

[0044] Figure 6 The present invention is a flow chart of a method for preparing a temperature-triggered burn dressing.

[0045] Figure 7 It is a flow chart of a method for preparing PVA-PNIPAM hydrogel in a method for preparing a temperature-triggered burn dressing of the present invention.

[0046] In the figure: flash-steamed nonwoven fabric 1, first release paper 2, sodium alginate carrier 3, second release paper 4, third carrier 5, ammonium nitrate powder 6, first carrier 7, PVA-PNIPAM hydrogel 8, second carrier 9, fixing area 10, sticky area 11, placement area 12, adhesive 13. DETAILED DESCRIPTION

[0047] The present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0048] A temperature-triggered burn dressing, comprising: a first release paper 2, a second release paper 4, a flash-steamed nonwoven fabric 1, a PVA-PNIPAM hydrogel 8, ammonium nitrate powder 6, a sodium alginate carrier 3, a first carrier 7, a second carrier 9 and a third carrier 5;

[0049] A fixing area 10 is formed at a central position on the top surface of the flash-steamed nonwoven fabric 1, and an adhesive area 11 is formed at other positions on the top surface of the flash-steamed nonwoven fabric 1. The bottom surface of the sodium alginate carrier 3 is fixed at the fixing area 10. The sodium alginate carrier 3 includes a first carrier 7, a second carrier 9 and a third carrier 5. The bottom surface of the first carrier 7 is fixed at the fixing area 10, and the bottom surface of the second carrier 9 is fixed to the top surface of the first carrier 7. The ammonium nitrate powder 6 is applied to a position between the first carrier 7 and the second carrier 9. The bottom surface of the third carrier 5 is fixed at the fixing area 10. The outer side of the first carrier 7 is fixed to a position on the inner wall of the third carrier 5 close to its lower end surface, and the outer side of the second carrier 9 is fixed to the inner wall of the third carrier 5 close to its upper end surface. At the lower end surface, a placement area 12 located at the inner upper side of the third carrier 5 is formed on the top surface of the second carrier 9, and the PVA-PNIPAM hydrogel 8 is fixed in the placement area 12. The bottom surface of the PVA-PNIPAM hydrogel 8 is adhered to the top surface of the second carrier 9, and the periphery of the PVA-PNIPAM hydrogel 8 is adhered to the inner wall of the third carrier 5. The PVA-PNIPAM hydrogel 8, the second carrier 9, the ammonium nitrate powder 6, the first carrier 7 and the flash-steamed non-woven fabric 1 are distributed in sequence from top to bottom. The adhesive 13 is adhered to the adhesive area 11, and the bottom surface of the first release paper 2 is attached to the top surface of the adhesive 13, and the bottom surface of the second release paper 4 is attached to the top surface of the PVA-PNIPAM hydrogel 8.

[0050] The length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively. The length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively. The first carrier 7 and the second carrier 9 have the same size. The length, width and height of the placement area 12 are 10 cm, 10 cm and 0.2 cm respectively.

[0051] The length, width and height of the PVA-PNIPAM hydrogel 8 are 10 cm, 10 cm and 0.2 cm respectively, and the size of the PVA-PNIPAM hydrogel 8 is compatible with the size of the placement area 12 .

[0052] The length and width of the flash-steamed nonwoven fabric 1 are both 14 cm, and the width (d) of the adhesive area 11 is 2 cm.

[0053] A method for preparing a temperature-triggered burn dressing, the method comprising the following steps:

[0054] S1, first put 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water into a container, then use a heating device to continuously heat and stir the container, the polyvinyl alcohol and the deionized water at 90° C., and after stirring until the polyvinyl alcohol in the container is completely dissolved, cool it to room temperature to obtain a polyvinyl alcohol solution;

[0055] S2, then adding 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of ammonium persulfate and 18-27 parts by weight of N-isopropylacrylamide into the cooled polyvinyl alcohol solution in sequence, mixing and stirring, and stirring the polyvinyl alcohol solution until the N-isopropylacrylamide is completely dissolved to obtain a preliminary mixed solution;

[0056] S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added into the preliminary mixed solution, and the mixture is stirred for five minutes under ventilation to obtain a final mixed solution;

[0057] S4, then injecting the final mixed solution into a sealed molding mold for packaging, and placing the mold in an environment of 8°C for 24 hours, and finally obtaining PVA-PNIPAM hydrogel 8;

[0058] S5, first apply 50-100 parts by weight of ammonium nitrate powder 6 on the surface of the first carrier 7 to obtain a starting carrier, then apply environmentally friendly wood glue on the edge of the surface, and then cover the second carrier 9 on the first carrier 7 to cover the surface to form a preliminary carrier;

[0059] S6, then apply environmentally friendly wood glue on the periphery of the preliminary carrier, and put it into the third carrier 5, after the environmentally friendly wood glue is air-dried, the first carrier 7, the second carrier 9 and the third carrier 5 form a sodium alginate carrier 3;

[0060] S7, firstly, the PVA-PNIPAM hydrogel 8 obtained according to step S4 is adhered to the placement area 12 of the sodium alginate carrier 3 according to its own viscosity to obtain an initial dressing;

[0061] S8. Fix the initial dressing on the fixing area 10 of the flash nonwoven fabric 1 by using environmentally friendly wood glue, then apply adhesive 13 on the sticky area 11 on the flash nonwoven fabric 1, and attach the first release paper 2 to the adhesive 13 and the second release paper 4 to the PVA-PNIPAM hydrogel 8, respectively, to finally obtain the final dressing.

[0062] The amount of polyvinyl alcohol used is 10 parts by weight, the amount of deionized water used is 90 parts by weight, the amount of N,N-methylenebisacrylamide used is 0.0616 parts by weight, the amount of ammonium persulfate used is 0.3 parts by weight, the amount of N-isopropylacrylamide used is 18 parts by weight, the amount of tetramethylethylenediamine used is 0.0002 parts by weight, and the amount of ammonium nitrate powder 6 used is 90 parts by weight.

[0063] In the step S1, the parameter of the heating and stirring is 500-600r / min, in the step S2, the parameter of the mixing and stirring is 500-600r / min, in the step S3, the parameter of the ventilation and stirring is 500-600r / min, in the step S1, the heating and stirring time is greater than 2h, and in the step S2, the mixing and stirring time is greater than 30min.

[0064] In step S5, the starting vector is obtained according to the following steps:

[0065] Step 1: first, lay the first carrier 7 flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder 6 and sprinkle it on the surface of the first carrier 7;

[0066] Step 2: Take another clean cotton swab, and then use the cotton swab to evenly spread the ammonium nitrate powder 6 that has fallen on the first carrier 7 above onto the surface of the first carrier 7, so that the ammonium nitrate powder 6 adheres to the fiber fluff on the surface of the first carrier 7 to obtain a starting carrier.

[0067] In step S6, the sodium alginate carrier 3 is obtained according to the following steps:

[0068] Step 1: First, select a sodium alginate block with the dimensions of 10.2 cm in length, 10.2 cm in width and 0.6 cm in height, and then cut a square hole on the sodium alginate block according to the length and width of the first carrier 7 and the second carrier 9 to obtain a third carrier 5 with a hollow interior;

[0069] Step 2: first apply environmentally friendly wood glue on the periphery of the preliminary carrier, then move the preliminary carrier into the third carrier 5 obtained in the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier 5. After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier 5 can form a sodium alginate carrier 3.

[0070] In step S8, the final dressing is obtained according to the following steps:

[0071] The first step: applying adhesive 13 to the adhesive area 11 on the flash nonwoven fabric 1;

[0072] Step 2: first prepare a first release paper 2 of the same size as the flash nonwoven fabric 1, then cut a perforation of corresponding size at the center of the first release paper 2 according to the length and width of the sodium alginate carrier 3, then let the first release paper 2 pass through the sodium alginate carrier 3 through the perforation, and adhere to the adhesive 13 on the adhesive area 11, and completely cover the adhesive 13;

[0073] Step 3: First prepare a second release paper 4 of the same size as the sodium alginate carrier 3, and then attach the second release paper 4 to the PVA-PNIPAM hydrogel 8 based on the second step, so that the second release paper 4 completely covers the PVA-PNIPAM hydrogel 8 and the sodium alginate carrier 3, and finally obtain the final dressing.

[0074] The supplementary technical features of the present invention are as follows:

[0075] The adhesive 13 involved in the present invention is preferably a medical adhesive, the main components of which are n-butyl a-cyanoacrylate, sulfur dioxide and hydroquinone, and have the characteristics of high viscosity, rapid bonding speed, non-toxicity, easy tearing and non-adhesion. The adhesive can play the role of a medical pressure-sensitive adhesive when combined with the flash-steamed nonwoven fabric 1, and does not affect the skin while being close to the skin;

[0076] The shape of the sodium alginate carrier 3 involved in the present invention is preferably a rectangular parallelepiped with a hollow portion near the top surface and a missing top surface. The sodium alginate carrier 3 is preferably Huaxia Junan alginate dressing. The sodium alginate carrier 3 will form a layer of hydrogel after absorbing water. The layer of hydrogel can block the reaction and prevent the ammonium nitrate solution from contacting the skin.

[0077] The mixing stirring and aeration stirring involved in the present invention are preferably ice-water bath stirring.

[0078] Embodiment 1:

[0079] See also Figure 1-Figure 3A temperature-triggered burn dressing comprises: a first release paper 2, a second release paper 4, a flash nonwoven fabric 1, a PVA-PNIPAM hydrogel 8, ammonium nitrate powder 6, a sodium alginate carrier 3, a first carrier 7, a second carrier 9 and a third carrier 5; a fixing area 10 is formed at a central portion on the top surface of the flash nonwoven fabric 1, and an adhesive area 11 is formed at other portions of the top surface of the flash nonwoven fabric 1; the bottom surface of the sodium alginate carrier 3 is fixed at the fixing area 10; the sodium alginate carrier 3 comprises a first carrier 7, a second carrier 9 and a third carrier 5; the bottom surface of the first carrier 7 is fixed at the fixing area 10, the bottom surface of the second carrier 9 is fixed to the top surface of the first carrier 7, the ammonium nitrate powder 6 is applied to a portion between the first carrier 7 and the second carrier 9, the bottom surface of the third carrier 5 is fixed at the fixing area 10, and the outer side of the first carrier 7 is fixed at The outer side of the second carrier 9 is fixed on the inner wall of the third carrier 5 near its lower end surface, and a placement area 12 located on the inner upper side of the third carrier 5 is formed on the top surface of the second carrier 9. The PVA-PNIPAM hydrogel 8 is fixed in the placement area 12, and the bottom surface of the PVA-PNIPAM hydrogel 8 is adhered to the top surface of the second carrier 9. The periphery of the PVA-PNIPAM hydrogel 8 is adhered to the inner wall of the third carrier 5. The PVA-PNIPAM hydrogel 8, the second carrier 9, the ammonium nitrate powder 6, the first carrier 7 and the flash-steamed nonwoven fabric 1 are distributed in sequence from top to bottom. The adhesive 13 is adhered to the adhesive area 11, and the bottom surface of the first release paper 2 is attached to the top surface of the adhesive 13. The bottom surface of the second release paper 4 is attached to the top surface of the PVA-PNIPAM hydrogel 8.

[0080] During application, when burns occur on human skin, the dressing can be used for first aid treatment. During the first aid treatment, first observe whether the surface skin of the wound is damaged. When the surface skin is damaged, the wound must be cleaned before using the dressing. When the surface skin is not damaged, the dressing can be used directly. When dressing, first peel off the first release paper 2 and the second release paper 4, then cover the wound with the PVA-PNIPAM hydrogel 8, and connect the adhesive 13 on the flash nonwoven fabric 1 to the skin at the edge of the wound, and absorb heat from the wound through the PVA-PNIPAM hydrogel 8. Cooling work, and after the PVA-PNIPAM hydrogel 8 absorbs heat, the PVA-PNIPAM hydrogel 8 will shrink and release water. The released water will dissolve the ammonium nitrate powder 6 between the first carrier 7 and the second carrier 9 through absorption and conduction by the second carrier 9. The ammonium nitrate powder 6 reacts and absorbs heat after contacting with water, and then further absorbs heat and cools the wound. Under the heat absorption and cooling of the PVA-PNIPAM hydrogel 8 and the ammonium nitrate powder 6, the wound can be effectively cooled, and more heat from the wound can be transferred to the dressing with a lower temperature to avoid more damage to the protective deep tissue of the wound.

[0081] The principle of heat absorption and cooling of ammonium nitrate powder 6 and water is as follows:

[0082] When ammonium nitrate crystals come into contact with water, they dissociate into the ions NH 4 + with NO 3 - Dissociation requires energy because it destroys the strong electrostatic attraction between ions, which will cause the ammonium nitrate crystals to absorb heat from the surrounding environment during the dissociation process. Therefore, the ammonium nitrate powder 6 will absorb heat and cool down after contacting water.

[0083] The principle of PVA-PNIPAM hydrogel 8 absorbing heat and releasing water is as follows:

[0084] PVA-PNIPAM hydrogel 8 contains two parts, amide and isopropyl, and has a critical solution temperature of 34 °C in aqueous medium; Figure 4As shown, when PVA-PNIPAM hydrogel 8 is near the critical solution temperature, PVA-PNIPAM hydrogel 8 will exhibit a drastic and reversible volume phase change by expanding or contracting, accompanied by changes in hydrophilicity and transparency. When the contact temperature of PVA-PNIPAM hydrogel 8 is lower than the critical solution temperature of PNIPAM hydrogel, the hydrogen bonds between the hydrophilic amide groups and the water molecules offset the hydrophobic interactions between the isopropyl groups, and a highly organized layer of water molecules will be formed around the amide groups; when the contact temperature of PVA-PNIPAM hydrogel 8 is higher than its critical solution temperature, the hydrogen bonds in PVA-PNIPAM hydrogel 8 are weakened, and the hydrophobic interactions between the isopropyl groups become stronger, and the PNIPAM chains therein are dehydrated and aggregated into a tightly packed spherical conformation. Therefore, PVA-PNIPAM hydrogel 8 absorbs heat and releases water.

[0085] The temperature-triggered burn dressing can be stored at room temperature and used at any time because its component PVA-PNIPAM hydrogel 8 will only release water when it contacts an object with a temperature higher than its critical dissolution temperature and absorbs heat when reacting with ammonium nitrate powder 6. It can immediately react and cool down the wound after contacting it, thereby quickly cooling the wound.

[0086] This temperature-triggered burn dressing is aimed at first aid treatment. During the use of the dressing, there is no need to cover the wound for a long time. During the cold compress process, it can also reduce the tissue fluid that appears when the surface skin is damaged. At the same time, PVA-PNIPAM hydrogel 8 has good biocompatibility and will not cause adverse effects on the wound. The water it releases does not contain other chemicals and will not cause irritation or damage to the wound. It is highly safe.

[0087] Embodiment 2:

[0088] The basic content is the same as that of Example 1, except that:

[0089] See also Figure 2-Figure 3 In this embodiment, the length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively, the length, width and height of the first carrier 7 are 10 cm, 10 cm and 0.2 cm respectively, the first carrier 7 and the second carrier 9 have the same size, the length, width and height of the placement area 12 are 10 cm, 10 cm and 0.2 cm respectively; the length, width and height of the PVA-PNIPAM hydrogel 8 are 10 cm, 10 cm and 0.2 cm respectively, and the size of the PVA-PNIPAM hydrogel 8 is adapted to the size of the placement area 12; the length and width of the flash nonwoven fabric 1 are both 14 cm, and the width (d) of the adhesive area 11 is 2 cm.

[0090] When used, the size of a single piece of PVA-PNIPAM hydrogel 8 can adapt to a small area of ​​wounds and cover the wounds. At the same time, in the process of absorbing heat and cooling a large area of ​​wounds, the adhesive areas 11 at the flash-steamed non-woven fabrics 1 on multiple dressings can be overlapped up and down, and the two flash-steamed non-woven fabrics 1 can be connected by an adhesive 13 to combine multiple dressings together. After the multiple dressings are combined, they can adapt to large area wounds. When multiple dressings are assembled, two adjacent PVA-PNIPAM hydrogels 8 will abut against each other, so that the PVA-PNIPAM hydrogel 8 can cover all wounds.

[0091] Embodiment 3:

[0092] The basic content is the same as that of Example 1, except that:

[0093] See also Figure 6-Figure 7A method for preparing a temperature-triggered burn dressing, the method comprising the following steps: S1, firstly putting 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water into a container, and then using a heating device to continuously heat and stir the container, the polyvinyl alcohol and the deionized water at 90°C, and after stirring until the polyvinyl alcohol in the container is completely dissolved, cooling it to room temperature to obtain a polyvinyl alcohol solution; S2, then adding 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added into the preliminary mixed solution, and the final mixed solution is obtained after ventilation and stirring for five minutes; S4, then the final mixed solution is injected into the sealing molding mold for packaging, and the The mold is placed in an environment of 8°C for 24 hours, and finally a PVA-PNIPAM hydrogel 8 is obtained; S5, 50-100 parts by weight of ammonium nitrate powder 6 is first applied on the surface of the first carrier 7 to obtain a starting carrier, and then environmentally friendly wood glue is applied on the edge of the surface, and then the second carrier 9 is covered on the first carrier 7 to cover the surface to form a preliminary carrier; S6, then environmentally friendly wood glue is applied on the periphery of the preliminary carrier, and it is placed in the third carrier 5. After the environmentally friendly wood glue is air-dried, the first carrier 7, the second carrier 9 and the third carrier 5 are Three carriers 5 form a sodium alginate carrier 3; S7, firstly adhere the PVA-PNIPAM hydrogel 8 obtained according to step S4 to the placement area 12 of the sodium alginate carrier 3 according to its own viscosity to obtain an initial dressing; S8, then fix the initial dressing to the fixing area 10 of the flash nonwoven fabric 1 by environmentally friendly wood glue, and then apply adhesive to the adhesive area 11 on the flash nonwoven fabric 1, and respectively attach the first release paper 2 to the adhesive and the second release paper 4 to the PVA-PNIPAM hydrogel 8 to finally obtain the final dressing.

[0094] During application, after the dressing comes into contact with the wound, the PVA-PNIPAM hydrogel 8 will release 15 ml of water, and more than 80% of the water in the PVA-PNIPAM hydrogel 8 can be released within 1 minute, and the remaining water will be completely released after 3-5 minutes. After the ammonium nitrate powder 6 dissolves in water, the temperature of the wound can be maintained at 10-15°C, and the maintenance time is 30-60 minutes. During the use of the dressing, small and medium-sized mild burns should be cold compressed for 30-60 minutes, and the dressing should be changed every 30 minutes if the wound is painless or slightly painful; small and medium-sized moderate burns should be cold compressed for 20 minutes and the dressing should be changed until there is no obvious burning pain in the wound; for larger areas or more serious burns, the dressing should be cold compressed for 20 minutes and the dressing should be changed.

[0095] Embodiment 4:

[0096] The basic content is the same as that of Example 3, except that:

[0097] See also Figure 6 In this embodiment, the amount of polyvinyl alcohol used is 10 parts by weight, the amount of deionized water used is 90 parts by weight, the amount of N,N-methylenebisacrylamide used is 0.0616 parts by weight, the amount of ammonium persulfate used is 0.3 parts by weight, the amount of N-isopropylacrylamide used is 18 parts by weight, the amount of tetramethylethylenediamine used is 0.0002 parts by weight, and the amount of ammonium nitrate powder 6 used is 90 parts by weight.

[0098] The above materials are prepared according to the corresponding weight portions to obtain two PVA-PNIPAM hydrogels 8 with a water release amount of 15 ml. The reaction of 15 ml of water and 90 weight portions of ammonium nitrate powder 6 can maintain the temperature of the wound at 10-15°C within 30min-60min. At the same time, 90 weight portions of ammonium nitrate powder 6 can satisfy the first carrier 7 and the second carrier 9 with a length and width of 10 cm.

[0099] Embodiment 5:

[0100] The basic content is the same as that of Example 3, except that:

[0101] See also Figure 6 In this embodiment, the heating and stirring parameters in step S1 are 500-600r / min, the mixing and stirring parameters in step S2 are 500-600r / min, the ventilation and stirring parameters in step S3 are 500-600r / min, the heating and stirring time in step S1 is greater than 2h, and the mixing and stirring time in step S2 is greater than 30min.

[0102] Embodiment 6:

[0103] The basic content is the same as that of Example 3, except that:

[0104] See also Figure 6 In step S5 of this embodiment, the starting carrier is obtained according to the following steps: the first step: firstly, the first carrier 7 is spread flat on the table, and then a certain amount of ammonium nitrate powder 6 is taken out with a medicine spoon and sprinkled on the surface of the first carrier 7; the second step: then a clean cotton swab is taken, and then the ammonium nitrate powder 6 falling on the first carrier 7 is evenly spread on the surface of the first carrier 7 with the cotton swab, so that the ammonium nitrate powder 6 adheres to the fiber fluff on the surface of the first carrier 7, such as Figure 5 As shown, the starting vector was obtained.

[0105] Embodiment 7:

[0106] The basic content is the same as that of Example 3, except that:

[0107] See also Figure 6 In step S6 of this embodiment, the sodium alginate carrier 3 is obtained according to the following steps: the first step: first select a sodium alginate block with a length, width and height of 10.2 cm, 10.2 cm and 0.6 cm respectively, and then cut square holes on the sodium alginate block according to the length and width of the first carrier 7 and the second carrier 9 to obtain a third carrier 5 with a hollow interior; the second step: first apply environmentally friendly wood glue on the periphery of the preliminary carrier, and then move the preliminary carrier into the third carrier 5 obtained by the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier 5, and after the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier 5 can form a sodium alginate carrier 3.

[0108] Embodiment 8:

[0109] The basic content is the same as that of Example 3, except that:

[0110] See also Figure 6 In step S8 of this embodiment, the final dressing is obtained according to the following steps: the first step: applying adhesive 13 on the adhesive area 11 of the flash nonwoven fabric 1; the second step: first preparing a first release paper 2 of the same size as the flash nonwoven fabric 1, and then cutting a perforation of corresponding size at the center of the first release paper 2 according to the length and width of the sodium alginate carrier 3, and then allowing the first release paper 2 to pass through the sodium alginate carrier 3 through the perforation, and attaching it to the adhesive 13 on the adhesive area 11, and completely covering the adhesive 13; the third step: first preparing a second release paper 4 of the same size as the sodium alginate carrier 3, and then attaching the second release paper 4 to the PVA-PNIPAM hydrogel 8 on the basis of the second step, so that the second release paper 4 completely covers the PVA-PNIPAM hydrogel 8 and the sodium alginate carrier 3, and finally obtaining the final dressing.

[0111] The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiment. Any equivalent modifications or changes made by ordinary technicians in this field based on the contents disclosed by the present invention should be included in the protection scope recorded in the claims.

Claims

1. A temperature-triggered burn dressing, characterized in that: The temperature-triggered burn dressing comprises: a first release paper (2), a second release paper (4), a flash-steamed nonwoven fabric (1), a PVA-PNIPAM hydrogel (8), ammonium nitrate powder (6), a sodium alginate carrier (3), a first carrier (7), a second carrier (9) and a third carrier (5); A fixing area (10) is formed at a central position on the top surface of the flash-steamed nonwoven fabric (1), and an adhesive area (11) is formed at other positions on the top surface of the flash-steamed nonwoven fabric (1). The bottom surface of the sodium alginate carrier (3) is fixed at the fixing area (10). The sodium alginate carrier (3) comprises a first carrier (7), a second carrier (9) and a third carrier (5). The bottom surface of the first carrier (7) is fixed at the fixing area (10), and the bottom surface of the second carrier (9) is fixed to the top surface of the first carrier (7). The ammonium nitrate powder (6) is applied to a position between the first carrier (7) and the second carrier (9), and the bottom surface of the third carrier (5) is fixed at the fixing area (10). The outer side of the first carrier (7) is fixed to a position on the inner wall of the third carrier (5) close to its lower end surface, and the outer side of the second carrier (9) is fixed to the inner wall of the third carrier (5). A placement area (12) located at the inner upper side of the third carrier (5) is formed on the top surface of the second carrier (9) near its lower end surface. The PVA-PNIPAM hydrogel (8) is fixed in the placement area (12). The bottom surface of the PVA-PNIPAM hydrogel (8) is adhered to the top surface of the second carrier (9). The periphery of the PVA-PNIPAM hydrogel (8) is adhered to the inner wall of the third carrier (5). The PVA-PNIPAM hydrogel (8), the second carrier (9), the ammonium nitrate powder (6), the first carrier (7) and the flash nonwoven fabric (1) are arranged in sequence from top to bottom. An adhesive (13) is adhered to the adhesive area (11). The bottom surface of the first release paper (2) is attached to the top surface of the adhesive (13). The bottom surface of the second release paper (4) is attached to the top surface of the PVA-PNIPAM hydrogel (8).

2. A temperature-triggered burn dressing according to claim 1, characterized in that: The length, width and height of the first carrier (7) are 10 cm, 10 cm and 0.2 cm respectively. The length, width and height of the first carrier (7) are 10 cm, 10 cm and 0.2 cm respectively. The first carrier (7) and the second carrier (9) have the same size. The length, width and height of the placement area (12) are 10 cm, 10 cm and 0.2 cm respectively.

3. A temperature-triggered burn dressing according to claim 2, characterized in that: The length, width and height of the PVA-PNIPAM hydrogel (8) are 10 cm, 10 cm and 0.2 cm respectively, and the size of the PVA-PNIPAM hydrogel (8) is compatible with the size of the placement area (12).

4. The temperature-triggered burn dressing according to claim 1, characterized in that: The length and width of the flash-steamed nonwoven fabric (1) are both 14 cm, and the width (d) of the adhesive area (11) is 2 cm.

5. A method for preparing the temperature-triggered burn dressing according to claim 1, characterized in that: The preparation method comprises the following steps: S1, first put 10-30 parts by weight of polyvinyl alcohol and 90-150 parts by weight of deionized water into a container, then use a heating device to continuously heat and stir the container, the polyvinyl alcohol and the deionized water at 90° C., and after stirring until the polyvinyl alcohol in the container is completely dissolved, cool it to room temperature to obtain a polyvinyl alcohol solution; S2, then adding 0.06-0.12 parts by weight of N,N-methylenebisacrylamide, 0.3-0.5 parts by weight of ammonium persulfate and 18-27 parts by weight of N-isopropylacrylamide into the cooled polyvinyl alcohol solution in sequence, mixing and stirring, and stirring the polyvinyl alcohol solution until the N-isopropylacrylamide is completely dissolved to obtain a preliminary mixed solution; S3, then nitrogen is introduced into the preliminary mixed solution, and 0.0002-0.0005 parts by weight of tetramethylethylenediamine is added into the preliminary mixed solution, and the mixture is stirred for five minutes under ventilation to obtain a final mixed solution; S4, then injecting the final mixed solution into a sealed molding mold for encapsulation, and placing the mold at 8°C for 24 hours, and finally obtaining PVA-PNIPAM hydrogel (8); S5, first apply 50-100 parts by weight of ammonium nitrate powder (6) on the surface of the first carrier (7) to obtain a starting carrier, then apply environmentally friendly wood glue on the edge of the surface, and then cover the second carrier (9) on the first carrier (7) to cover the surface to form a preliminary carrier; S6, then apply environmentally friendly wood glue on the outer periphery of the preliminary carrier, and place it into the third carrier (5). After the environmentally friendly wood glue is air-dried, the first carrier (7), the second carrier (9) and the third carrier (5) form a sodium alginate carrier (3); S7, firstly, the PVA-PNIPAM hydrogel (8) obtained according to step S4 is adhered to the placement area (12) of the sodium alginate carrier (3) according to its own viscosity to obtain an initial dressing; S8. The initial dressing is then fixed to the fixing area (10) of the flash nonwoven fabric (1) by using environmentally friendly wood glue, and then the adhesive (13) is applied to the sticky area (11) on the flash nonwoven fabric (1), and the first release paper (2) is attached to the adhesive (13), and the second release paper (4) is attached to the PVA-PNIPAM hydrogel (8), and finally the final dressing is obtained.

6. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: The amount of polyvinyl alcohol used is 10 parts by weight, the amount of deionized water used is 90 parts by weight, the amount of N,N-methylenebisacrylamide used is 0.0616 parts by weight, the amount of ammonium persulfate used is 0.3 parts by weight, the amount of N-isopropylacrylamide used is 18 parts by weight, the amount of tetramethylethylenediamine used is 0.0002 parts by weight, and the amount of ammonium nitrate powder (6) used is 90 parts by weight.

7. A method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In the step S1, the parameter of the heating and stirring is 500-600r / min, in the step S2, the parameter of the mixing and stirring is 500-600r / min, in the step S3, the parameter of the ventilation and stirring is 500-600r / min, in the step S1, the heating and stirring time is greater than 2h, and in the step S2, the mixing and stirring time is greater than 30min.

8. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In step S5, the starting vector is obtained according to the following steps: Step 1: first, spread the first carrier (7) flat on the table, and then use a medicine spoon to take out a certain amount of ammonium nitrate powder (6) and sprinkle it on the surface of the first carrier (7); Step 2: Take another clean cotton swab, and then use the cotton swab to evenly spread the ammonium nitrate powder (6) that has fallen on the above-mentioned first carrier (7) on the surface of the first carrier (7), so that the ammonium nitrate powder (6) adheres to the fiber fluff on the surface of the first carrier (7) to obtain a starting carrier.

9. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In step S6, the sodium alginate carrier (3) is obtained according to the following steps: Step 1: First, a sodium alginate block with a length, width and height of 10.2 cm, 10.2 cm and 0.6 cm is selected, and then a square hole is cut out on the sodium alginate block according to the length and width of the first carrier (7) and the second carrier (9), so as to obtain a third carrier (5) with a hollow interior; Step 2: first apply environmentally friendly wood glue on the outer periphery of the preliminary carrier, then move the preliminary carrier into the third carrier (5) obtained in the first step, and make the bottom surface of the preliminary carrier flush with the lower end surface of the third carrier (5). After the environmentally friendly wood glue is air-dried, the preliminary carrier and the third carrier (5) can form a sodium alginate carrier (3).

10. The method for preparing a temperature-triggered burn dressing according to claim 5, characterized in that: In step S8, the final dressing is obtained according to the following steps: The first step is to apply adhesive (13) to the adhesive area (11) on the flash-steamed nonwoven fabric (1); Step 2: first prepare a first release paper (2) of the same size as the flash nonwoven fabric (1), then cut a perforation of a corresponding size at the center of the first release paper (2) according to the length and width of the sodium alginate carrier (3), then allow the first release paper (2) to pass through the sodium alginate carrier (3) through the perforation and adhere to the adhesive (13) on the adhesive area (11) to completely cover the adhesive (13); Step 3: First prepare a second release paper (4) of the same size as the sodium alginate carrier (3), and then attach the second release paper (4) to the PVA-PNIPAM hydrogel (8) based on the second step, so that the second release paper (4) completely covers the PVA-PNIPAM hydrogel (8) and the sodium alginate carrier (3), and finally obtain the final dressing.

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