Rabies virus antibody detection device
By designing a rabies virus antibody detection device, and using centrifugation and liquid aspiration mechanism to quickly detect antibodies in serum, the problem of long detection time in the prior art was solved, and rapid and accurate antibody detection results were achieved.
Patent Information
- Application Number
- CN202411310725.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-19
- Publication Date
- 2024-12-20
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The prior art cannot quickly detect whether the subject is tested to produce rabies virus antibodies, and requires the use of multiple instruments in the laboratory for detection, which takes a long time.
A rabies virus antibody detection device is designed, including a base, a lower cylinder and an upper cylinder, with a built-in centrifugal mechanism and a liquid absorbing mechanism. The serum is placed on the test paper through centrifugal and liquid absorbing mechanisms, and fixed by magnetic blocks and adsorption rods. Test strips promote the structure to achieve multi-sample testing, ensuring the serum volume is fixed and accurate dripping.
It realizes rapid detection of obtaining test results within half an hour to one hour, simplifies the operation process, improves work efficiency, and ensures the accuracy of test results.
Smart Images
Figure CN119165160A_ABST
Abstract
Description
Technical Field
[0004] The present invention relates to the technical field of antibody detection, and in particular to a rabies virus antibody detection device. Background Art
[0005] Rabies virus is the pathogen of rabies, and my country is a country with a high incidence of rabies. Since rabies is a zoonotic disease, most human rabies is transmitted by infected dogs that have close contact with humans. Its harm has attracted great attention from people. Rabies vaccine is a key factor in controlling rabies in humans and animals. The World Health Organization (WHO) Rabies Expert Committee believes that the neutralizing antibody titer in serum that effectively binds to rabies virus is ≥0.5 international units (IU / ml) to have sufficient protection. If the neutralizing antibody titer is <0.5IU / ml, multiple doses of booster immunization must be given until the antibody reaches the requirement. Rabies virus G protein is the only protein that induces the body to produce virus neutralizing antibodies. Therefore, using rabies virus G protein to detect the neutralizing antibody titer in serum is the most scientific and direct method.
[0006] The commonly used method at present is to use the corresponding test paper for detection. The specific method is to first draw a small amount of blood from the subject, then centrifuge it, extract the upper liquid to obtain serum, and then drop it on the reagent plate, compare the color of the test line and the control line, and then determine whether rabies virus IgG antibodies are produced in the body of the subject. The whole process needs to be completed in the laboratory using different instruments, and the test results cannot be obtained quickly. Summary of the invention
[0007] The purpose of the present invention is to provide a rabies virus antibody detection device to solve the following technical problem: the prior art cannot quickly detect whether a subject has produced antibodies.
[0008] The purpose of the present invention can be achieved through the following technical solutions:
[0009] A rabies virus antibody detection device comprises a base, a lower cylinder located on the base, and an upper cylinder located on the lower cylinder, wherein the lower cylinder is a cylindrical cavity structure with an opening on the top, the upper cylinder is a cylindrical cavity structure with openings on the top and the bottom, a centrifugal mechanism is arranged in the lower cylinder, a side wall of the lower cylinder is provided with a plurality of mounting holes along the circumferential direction, a test paper placement block is movably arranged in the mounting hole, a plurality of magnetic blocks are fixed on the top wall of the upper cylinder, an adsorption rod is adsorbed on the bottom of the magnetic block, a movable plate is movably arranged in the upper cylinder, and one end of the adsorption rod is fixedly connected to the movable plate;
[0010] A plurality of liquid-absorbing mechanisms are arranged below the movable plate, and the liquid-absorbing mechanisms include a liquid-absorbing cylinder and a liquid-absorbing needle. The liquid-absorbing cylinder is clamped on the inner wall of the lower cylinder body, and the liquid-absorbing needle is fixed on the bottom wall of the movable plate. A liquid-absorbing tube is connected between the liquid-absorbing needle and the top of the liquid-absorbing cylinder, and a liquid-discharging tube is connected to one side of the bottom of the liquid-absorbing cylinder. A piston rod is movably arranged at the bottom of the liquid-absorbing cylinder, one end of the piston rod is connected to the first piston plate, and a pushing structure is arranged between the other end and the movable plate. When the movable plate descends, the first piston plate is driven down to utilize negative pressure to suck serum into the liquid-absorbing cylinder and discharge it through the liquid-discharging tube.
[0011] As a further solution of the present invention: the pushing mechanism includes multiple groups of pushing rods movably arranged on the movable plate, the multiple groups of pushing rods are distributed in a circular array on the movable plate, each group of pushing rods is provided with two pushing rods, a pushing ring is commonly fixed on the top of the multiple groups of pushing rods, a spring is mounted on the pushing rod, and the spring is located between the pushing ring and the movable plate, a force plate is fixed to the end of the piston rod away from the first piston plate, and force rods are symmetrically arranged on the force plate.
[0012] As a further solution of the present invention: a second piston plate is also provided in the liquid-piloting cylinder, the second piston plate is located above the first piston plate, a connecting rod is connected between the first piston plate and the second piston plate, through holes are provided on the first piston plate and the second piston plate, a guide rod is movably provided in the through hole, and the two ends of the guide rod are respectively fixed on the top wall and the bottom wall of the liquid-piloting cylinder, and a liquid inlet hole is provided on the guide rod.
[0013] As a further solution of the present invention: a handle bar is fixed on the upper surface of the movable plate.
[0014] As a further solution of the present invention: a perforated plate is symmetrically fixed to the top of the lower cylinder, a fixing block is symmetrically fixed to the bottom wall of the upper cylinder, and an insertion rod is fixed to the bottom of the fixing block, and the insertion rod matches the hole size of the perforated plate.
[0015] As a further solution of the present invention: the centrifugal mechanism includes a driving shaft installed on the bottom wall of the lower cylinder, a centrifugal disk is installed on the top of the driving shaft, a plurality of placement holes for placing coagulation promoting tubes are arranged in an array on the centrifugal disk, a centrifugal motor and a battery are arranged in the base, and the output shaft of the centrifugal motor is connected to the driving shaft.
[0016] As a further solution of the present invention: a placement groove is provided on the test paper placement block, and a plurality of support rods are arranged in a circular array on the bottom wall of the lower cylinder to keep the test paper placement block horizontal.
[0017] As a further solution of the present invention: a plurality of clamping plates are fixed on the inner wall of the lower cylinder along the circumferential direction, a clamping hole matching the size of the pipette cylinder is opened at one end of the clamping plate, clamping grooves are opened on both sides of the clamping hole, and clamping blocks matching the size of the clamping grooves are fixed on both sides of the top of the pipette cylinder.
[0018] Beneficial effects of the present invention:
[0019] (1) The present invention is provided with an upper cylinder, a lower cylinder, a centrifugal mechanism, a movable plate and a liquid aspiration mechanism. After the blood of the test subject is drawn, it is placed in a coagulation-promoting tube. The blood can be centrifuged by the centrifugal mechanism, and the upper serum can be aspirated by the liquid aspiration mechanism. The serum is dripped onto the test paper through a liquid discharge tube. By comparing the colors of the test line and the control line, it can be determined whether the test subject has produced anti-rabies virus IgG antibodies in his body. The test results can be obtained within half an hour to one hour, which is convenient and quick.
[0020] (2) The present invention sets the first piston plate, the second piston plate, the guide rod and the liquid inlet hole to ensure that the amount of serum dripping through the discharge tube is fixed. Since the blood of the subject is drawn manually, it is impossible to ensure that the amount drawn each time is completely consistent, resulting in different liquid levels in the coagulant tube. The first piston plate and the second piston plate cooperate to make the serum to be tested located between the first piston plate and the second piston plate. The amount of serum between the two is fixed, so that the amount of serum discharged is fixed, and the test result will not be affected by too much or too little serum.
[0021] (3) The present invention sets a pushing structure. When the movable plate descends, multiple pipette needles are first inserted into different coagulation promoting tubes respectively, and then the pushing ring is pressed down. Multiple groups of pushing rods can be used to push the first piston plates in different pipette cylinders to descend, and multiple samples can be tested at the same time, thereby improving work efficiency. The pipette cylinder can be recycled and reused. After a test is completed, a new pipette cylinder, pipette needle and other structures can be replaced to conduct another test. The operation is simple. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] The present invention will be further described below in conjunction with the accompanying drawings.
[0023] Figure 1 It is a schematic diagram of the structure of the present invention;
[0024] Figure 2 It is a schematic diagram of the structure of the lower cylinder and the upper cylinder of the present invention in a disassembled state;
[0025] Figure 3 It is a structural schematic diagram of the movable plate of the present invention;
[0026] Figure 4 It is a three-dimensional structural schematic diagram of the liquid pipette of the present invention;
[0027] Figure 5 It is a schematic diagram of the internal structure of the liquid-absorbing cylinder of the present invention;
[0028] Figure 6 It is a three-dimensional structural schematic diagram of the first piston plate, the second piston plate and the guide rod of the present invention;
[0029] Figure 7 It is a schematic diagram of the three-dimensional structure of the lower cylinder of the present invention;
[0030] Figure 8 It is a schematic diagram of the internal structure of the lower cylinder of the present invention.
[0031] In the figure: 1. base; 2. lower cylinder; 3. upper cylinder; 4. orifice plate; 5. fixed block; 6. plug rod; 7. centrifugal mechanism; 701. drive shaft; 702. centrifugal disk; 8. movable plate; 801. push rod; 802. push ring; 803. spring; 804. hand grip rod; 805. pipette cylinder; 806. pipette tube; 807. pipette needle; 808. discharge tube; 809. piston rod; 810. force plate; 811. force rod; 812. first piston plate; 813. second piston plate; 814. connecting rod; 815. guide rod; 816. liquid inlet hole; 9. magnetic block; 10. adsorption rod; 11. test paper placement block; 12. support rod; 13. clamping plate.
[0032] The drawings are only used for illustrative purposes and are not to be construed as limitations of the present invention. To better illustrate the present embodiment, some parts of the drawings may be omitted, enlarged, or reduced in size, and do not represent the size and shape of actual products. For those skilled in the art, it is understandable that some well-known structures and their descriptions may be omitted in the drawings. DETAILED DESCRIPTION
[0033] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0034] See also Figure 1-5As shown, the present invention is a rabies virus antibody detection device, comprising a base 1, a lower cylinder 2 located on the base 1, and an upper cylinder 3 located on the lower cylinder 2, the lower cylinder 2 is a cylindrical cavity structure with an opening on the top, the upper cylinder 3 is a cylindrical cavity structure with openings on the top and bottom, a centrifugal mechanism 7 is arranged in the lower cylinder 2, a side wall of the lower cylinder 2 is provided with a plurality of mounting holes along the circumferential direction, a test paper placement block 11 is movably arranged in the mounting hole, and a plurality of test paper placement blocks 11 are fixed on the top wall of the upper cylinder 3. A magnetic block 9 is provided, and an adsorption rod 10 is adsorbed on the bottom of the magnetic block 9. A movable plate 8 is movably provided in the upper cylinder 3, and one end of the adsorption rod 10 is fixedly connected to the movable plate 8. A plurality of liquid suction mechanisms are provided below the movable plate 8, and the liquid suction mechanisms include a liquid suction cylinder 805 and a liquid suction needle 807. The liquid suction cylinder 805 is clamped on the inner wall of the lower cylinder 2, and the liquid suction needle 807 is fixed on the bottom wall of the movable plate 8. A liquid suction tube 806 is connected between the liquid suction needle 807 and the top of the liquid suction cylinder 805. The liquid suction cylinder 80 A discharge pipe 808 is connected to one side of the bottom of the pipette 805. A piston rod 809 is movably arranged at the bottom of the pipette 805. One end of the piston rod 809 is connected to a first piston plate 812, and a pushing structure is arranged between the other end and the movable plate 8. When the movable plate 8 descends, the first piston plate 812 is driven to descend, and the serum is sucked into the pipette 805 by negative pressure and discharged through the discharge pipe 808. The double-layer tube cavity design composed of the lower cylinder 2 and the upper cylinder 3 installed on the base 1 provides a closed and convenient running space for the blood sample, and cooperates with the centrifugal mechanism 7 in the lower cylinder 2 to achieve rapid centrifugation of the blood sample to obtain serum. The piston rod 809 cooperates with the first piston plate 812 and, through the pushing structure, when the movable plate 8 descends after the centrifugation is completed, this structure causes the first piston plate 812 to descend accordingly. The serum sample liquid that has been centrifuged is sucked into the pipette 805 by the generated negative pressure, and then discharged through the discharge pipe 808 for subsequent detection steps, accurately sucking the serum and effectively avoiding cross contamination.
[0035] See also Figure 2 , Figure 3 , Figure 4 and Figure 5The pushing mechanism includes a plurality of pushing rods 801 movably arranged on the movable plate 8, and the plurality of pushing rods 801 are distributed in a circular array on the movable plate 8, and each group of pushing rods 801 is provided with two pushing rods, and a pushing ring 802 is fixed to the top of the plurality of pushing rods 801, and a spring 803 is sleeved on the pushing rod 801, and the spring 803 is located between the pushing ring 802 and the movable plate 8, and a force plate 810 is fixed to the end of the piston rod 809 away from the first piston plate 812, and force rods 811 are symmetrically arranged on the force plate 810, and a hand grip rod is fixed to the upper surface of the movable plate 8 804; by evenly distributing a plurality of groups of push rods 801 in a circular array on the movable plate 8, each group is assisted by a spring 803 and is further provided with a push ring 802, the output and conduction efficiency of the driving force are greatly enhanced, and the uniform distribution of force is achieved. The movable plate 8 is first pushed down to insert a plurality of aspiration needles 807 into different coagulation promoting tubes. At this time, the push rod 801 is close to the force-bearing rod 811, and then the push ring 802 is pressed down. The push rod 801 is used to push the force-bearing rod 811 down, thereby driving the first piston plate 812 to descend to generate negative pressure and absorb serum.
[0036] See also Figure 5 and Figure 6 , a second piston plate 813 is further provided in the liquid pipette 805, and the second piston plate 813 is located above the first piston plate 812, and a connecting rod 814 is connected between the first piston plate 812 and the second piston plate 813, and a through hole is provided on the first piston plate 812 and the second piston plate 813, and a guide rod 815 is movably provided in the through hole, and the two ends of the guide rod 815 are respectively fixed on the top wall and the bottom wall of the liquid pipette 805, and a liquid inlet hole 816 is provided on the guide rod 815; since the blood of the subject is drawn manually, it is impossible to ensure that the amount drawn each time is completely consistent, resulting in different liquid levels in the coagulation tube. When the first piston plate 812 descends, the first piston plate 812 is used to draw blood from the subject. The second piston plate 813 is driven downward by the connecting rod 814, and the negative pressure generated causes the serum to fall on the second piston plate 813 and fall between the first piston plate 812 and the second piston plate 813 through the liquid inlet hole 816. As the first piston plate 812 and the second piston plate 813 continue to descend, the second piston plate 813 gradually separates from the liquid inlet hole 816. At this time, even if the serum is sucked again, the serum cannot enter between the first piston plate 812 and the second piston plate 813, and the serum between the first piston plate 812 and the second piston plate 813 is discharged through the drain pipe 808. The amount of serum discharged each time is fixed and will not be too much or too little, thereby ensuring the accuracy of the test results.
[0037] See also Figure 1 and Figure 2The top of the lower cylinder 2 is symmetrically fixed with a hole plate 4, the bottom wall of the upper cylinder 3 is symmetrically fixed with a fixing block 5, and the bottom of the fixing block 5 is fixed with an insertion rod 6, and the insertion rod 6 matches the hole size of the hole in the orifice plate 4; the lower cylinder 2 and the upper cylinder 3 are conveniently mechanically connected, and the insertion rod 6 at the bottom of the fixing block 5 matches the preset hole design of the orifice plate 4, ensuring that they can be firmly plugged together without using additional fastening means to form a reliable connection node, reducing the use of external fasteners and simplifying the assembly process.
[0038] See also Figure 7 and Figure 8 The centrifugal mechanism 7 includes a driving shaft 701 installed on the bottom wall of the lower cylinder 2, a centrifugal disk 702 is installed on the top of the driving shaft 701, and a plurality of placement holes for placing the coagulation-promoting tubes are arranged in an array on the centrifugal disk 702. A centrifugal motor and a battery are arranged in the base 1, and the output shaft of the centrifugal motor is connected to the driving shaft 701; by installing the centrifugal motor in the base 1, the output shaft of the motor is connected to the driving shaft 701 on the bottom wall of the lower cylinder 2 to drive the centrifugal disk 702 to rotate, thereby realizing high-speed centrifugation of the blood in the coagulation-promoting tube.
[0039] See also Figure 8 A placement groove is provided on the test paper placement block 11, and a plurality of support rods 12 are arranged in a circular array on the bottom wall of the lower cylinder 2 to keep the test paper placement block 11 horizontal.
[0040] See also Figure 2 , Figure 3 and Figure 8 A plurality of snap-in plates 13 are fixed on the inner wall of the lower cylinder body 2 along the circumferential direction, a snap-in hole matching the size of the pipette cylinder 805 is opened at one end of the snap-in plate 13, snap-in grooves are opened on both sides of the snap-in hole, and snap-in blocks matching the size of the snap-in grooves are fixed on both sides of the top of the pipette cylinder 805; it is convenient to fix the pipette cylinder 805 in the lower cylinder body 2 without affecting the normal progress of the centrifugation, and it is easy to disassemble, which is convenient for replacement after the detection is completed.
[0041] The working principle of the present invention is as follows: a blood sample of the subject is drawn and placed in a coagulation-promoting tube, and then a plurality of coagulation-promoting tubes are placed in the placement holes of the centrifugal disk 702 respectively, and then the upper cylinder 3 is connected to the lower cylinder 2, and the liquid pipette 805 is clamped with the clamping plate 13, and the insertion rod 6 at the bottom of the fixed block 5 is inserted into the preset hole of the orifice plate 4, and then the test paper is placed in the placement grooves of different test paper placement blocks 11, and inserted into the installation hole of the lower cylinder 2, and the blood sample is first allowed to stand for ten minutes, and then the centrifugal motor is started to centrifuge the blood at high speed for a period of time. After the centrifugation is completed, the operator The staff member holds the hand grip rod 804 to push the movable plate 8 down, and the adsorption rod 10 is separated from the magnetic block 9. First, multiple aspiration needles 807 are respectively inserted into different coagulation promoting tubes. At this time, the pushing rod 801 is close to the force rod 811, and then the pushing ring 802 is pressed down. Multiple groups of pushing rods 801 are synchronously lowered, and the pushing rod 801 is used to push the force rod 811 and the force plate 810 down, thereby driving the first piston plate 812 to descend to generate negative pressure, and the serum is sucked into the aspiration tube 805. The aspiration tube 806 is a flexible tube and will not hinder the movement of the movable plate 8 and other structures;
[0042] When the first piston plate 812 descends, the second piston plate 813 is driven to descend by the connecting rod 814, and the negative pressure generated causes the serum to fall on the second piston plate 813, and then fall into the space between the first piston plate 812 and the second piston plate 813 through the liquid inlet hole 816. As the first piston plate 812 and the second piston plate 813 continue to descend, the second piston plate 813 gradually separates from the liquid inlet hole 816. At this time, even if the serum is sucked again, the serum cannot enter the space between the first piston plate 812 and the second piston plate 813. The amount of serum discharged each time is fixed and will not be too much or too little, thereby ensuring the accuracy of the test results.
[0043] When the first piston plate 812 moves to the bottom of the drainage tube 808, the serum between the first piston plate 812 and the second piston plate 813 drips onto the test paper through the drainage tube 808. After waiting for a few minutes, the test paper placement block 11 is taken out, and the colors of the test line and the control line are compared to determine whether anti-rabies virus IgG antibodies are produced in the body of the subject. The test results can be obtained within half an hour to an hour, which is convenient and quick.
[0044] The above is a detailed description of an embodiment of the present invention, but the content is only a preferred embodiment of the present invention and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.
Claims
1. A rabies virus antibody detection device, comprising a base (1), a lower cylinder (2) located on the base (1), and an upper cylinder (3) located on the lower cylinder (2), It is characterized in that The lower cylinder (2) is a cylindrical cavity structure with an opening at the top, and the upper cylinder (3) is a cylindrical cavity structure with openings at the top and bottom. A centrifugal mechanism (7) is arranged in the lower cylinder (2). The side wall of the lower cylinder (2) is provided with a plurality of mounting holes along the circumferential direction, and a test paper placement block (11) is movably arranged in the mounting hole. A plurality of magnetic blocks (9) are fixed on the top wall of the upper cylinder (3), and an adsorption rod (10) is adsorbed on the bottom of the magnetic block (9). A movable plate (8) is movably arranged in the upper cylinder (3), and one end of the adsorption rod (10) is fixedly connected to the movable plate (8). A plurality of liquid aspiration mechanisms are arranged below the movable plate (8), and the liquid aspiration mechanisms include a liquid aspiration cylinder (805) and a liquid aspiration needle (807). The liquid aspiration cylinder (805) is clamped on the inner wall of the lower cylinder body (2), and the liquid aspiration needle (807) is fixed on the bottom wall of the movable plate (8). A liquid aspiration tube (806) is connected between the liquid aspiration needle (807) and the top of the liquid aspiration cylinder (805), and a liquid discharge tube (808) is connected to one side of the bottom of the liquid aspiration cylinder (805). A piston rod (809) is movably arranged at the bottom of the liquid aspiration cylinder (805), one end of the piston rod (809) is connected to a first piston plate (812), and a pushing structure is arranged between the other end and the movable plate (8). When the movable plate (8) descends, the first piston plate (812) is driven to descend, and serum is sucked into the liquid aspiration cylinder (805) by negative pressure and discharged through the liquid discharge tube (808).
2. A rabies virus antibody detection device according to claim 1, It is characterized in that The pushing mechanism comprises a plurality of groups of pushing rods (801) movably arranged on the movable plate (8), the plurality of groups of pushing rods (801) being distributed in a circular array on the movable plate (8), two pushing rods (801) being arranged in each group, a pushing ring (802) being fixed to the tops of the plurality of groups of pushing rods (801), a spring (803) being sleeved on the pushing rods (801), and the spring (803) being located between the pushing ring (802) and the movable plate (8), a force plate (810) being fixed to one end of the piston rod (809) away from the first piston plate (812), and force rods (811) being symmetrically arranged on the force plate (810).
3. A rabies virus antibody detection device according to claim 1, It is characterized in that A second piston plate (813) is also provided in the liquid suction cylinder (805), and the second piston plate (813) is located above the first piston plate (812). A connecting rod (814) is connected between the first piston plate (812) and the second piston plate (813). Through holes are provided on the first piston plate (812) and the second piston plate (813), and a guide rod (815) is movably provided in the through hole. The two ends of the guide rod (815) are respectively fixed on the top wall and the bottom wall of the liquid suction cylinder (805), and a liquid inlet hole (816) is provided on the guide rod (815).
4. A rabies virus antibody detection device according to claim 1, It is characterized in that A handle bar (804) is fixed to the upper surface of the movable plate (8).
5. A rabies virus antibody detection device according to claim 1, It is characterized in that A perforated plate (4) is symmetrically fixed to the top of the lower cylinder (2), a fixing block (5) is symmetrically fixed to the bottom wall of the upper cylinder (3), and an insertion rod (6) is fixed to the bottom of the fixing block (5), wherein the insertion rod (6) matches the hole size of the perforated plate (4).
6. A rabies virus antibody detection device according to claim 1, It is characterized in that The centrifugal mechanism (7) comprises a driving shaft (701) mounted on the bottom wall of the lower cylinder (2), a centrifugal disc (702) being mounted on the top of the driving shaft (701), a plurality of placement holes for placing pro-coagulation tubes being arranged in an array on the centrifugal disc (702), a centrifugal motor and a battery being arranged in the base (1), and an output shaft of the centrifugal motor being connected to the driving shaft (701).
7. A rabies virus antibody detection device according to claim 1, It is characterized in that The test paper placement block (11) is provided with a placement groove, and a plurality of support rods (12) are arranged in a circular array on the bottom wall of the lower cylinder (2) to keep the test paper placement block (11) horizontal.
8. A rabies virus antibody detection device according to claim 1, It is characterized in that A plurality of clamping plates (13) are fixed on the inner wall of the lower cylinder (2) along the circumferential direction, a clamping hole matching the size of the liquid pipette (805) is provided at one end of the clamping plate (13), clamping grooves are provided on both sides of the clamping hole, and clamping blocks matching the size of the clamping grooves are fixed on both sides of the top of the liquid pipette (805).