Cannabis oil composition and preparation method thereof

Abstract

There is provided a method of preparing a hemp oil composition, the method comprising the steps of eluting cannabinoid from a dried hemp plant material in a solvent by reflux for a predetermined time to obtain an eluate, filtering the eluate with a series of filters to obtain a filtrate, the solvent in the evaporated filtrate is condensed with a distiller to extract a distillate, and the distillate is purified by fractionation to remove the residual solvent to obtain the cannabis sativa extract. The method further comprises the following steps: carrying out redox reaction on the cannabis sativa extract to completely remove water in the cannabis sativa extract, and preparing CBN (cannabinol) with different percentages according to the time for which the redox reaction is carried out; and mixing the cannabis sativa extract with essential oil or base oil to obtain the cannabis sativa oil composition.

Description

Technical Field

[0001] The present invention relates generally to cannabis oil and cannabis oil compositions, and more particularly to a unique cannabis oil extraction process using a preferred ethanol solvent, and cannabis oil formulations of cannabis oil compositions with a base oil and related methods of preparation thereof. Background Art

[0002] The following discussion of the background art is intended only to facilitate an understanding of the present invention. The discussion does not constitute an acknowledgement or admission that any of the material referred to was or is part of the common general knowledge as of the priority date of this application.

[0003] The endocannabinoid system in the human body is a naturally occurring system that regulates a variety of physiological processes, such as appetite, memory, sleep, mood, pain perception, and immune response. When endocannabinoids are deficient or otherwise deficient, this often leads to disease. When the cannabis oil composition is ingested, the cannabinoids immediately bind to the endocannabinoid receptors CB1 (brain) and CB2 (immune system), and the released cannabinoids continuously bind to areas of the endocannabinoid system that need healing to maximize programmed cell death.

[0004] The biological processes that react and interact with the compounds in cannabis through the endocannabinoid system include the natural cannabinoids found in our bodies (such as 2-AG and Anandamide). These natural cannabinoids released by the body break down faster and are not as effective as cannabinoids extracted from cannabis. Depending on the ratio / strength of the cannabinoids ingested, they will have different effects on the body, so different ratios of cannabinoids can be formulated to treat different diseases. Scientists estimate that there are more than 80 unique cannabinoids in the cannabis plant that are very beneficial to the human body.

[0005] Bioactive extracts from the cannabis plant prepared and formulated according to existing methods may contain other undesirable compounds in addition to THC (tetrahydrocannabinol). Drugs containing this cannabinoid are often unstable because of undesirable side chemical reactions (e.g., formation of hydroquinone), which may result in patients not receiving the correct dosage of the drug.

[0006] In view of these shortcomings, the present invention attempts to propose possible solutions to at least partially solve the shortcomings that already exist in the existing traditional practice of preparing cannabis oil compositions. Summary of the invention

[0007] According to a first aspect of the present invention, there is provided a method for preparing a cannabis oil composition, the method comprising the following steps:

[0008] eluting cannabinoids from the dried cannabis plant material by refluxing the solvent for a predetermined period of time to obtain an eluate;

[0009] filtering the eluate through a series of filters to obtain a filtrate;

[0010] extracting a distillate by condensing and evaporating the solvent in the filtrate using a distiller;

[0011] purifying the distillate by fractional distillation to remove residual solvent to obtain a cannabis extract;

[0012] subjecting the cannabis extract to a redox reaction to remove water therefrom, thereby degrading tetrahydrocannabinol (THC) to produce CBN (cannabinol), the percentage concentration of CBN depending on the predetermined time of reflux; and

[0013] The cannabis extract at the percentage concentration is mixed with essential oil or carrier oil to obtain a cannabis oil composition.

[0014] In one embodiment, the cannabis plant material is selected from the non-exhaustive group consisting of a cannabis indica plant, a ruderalis plant, a sativa plant and / or a hybrid cannabis plant.

[0015] In one embodiment, the solvent is selected from the non-exhaustive group consisting of chloroform, light ether, ethanol isopropanol, methanol, dichloromethane, benzene and denatured ethanol.

[0016] In one embodiment, the predetermined time comprises a range of 0.5 hours to 8 hours.

[0017] In one embodiment, the predetermined time is determined according to the type of solvent used.

[0018] In one embodiment, the step of evaporating the solvent from the filtrate includes the step of adding colloidal silver water to the filtrate.

[0019] In one embodiment, the step of evaporating the solvent by condensation is performed at a temperature of 72°C to 78°C.

[0020] Condensation In one embodiment, the step of performing the redox reaction comprises adding colloidal silver water to the cannabis extract to prolong the redox reaction and / or determine the percentage concentration of the cannabis extract.

[0021] In one embodiment, the cannabis extract is subjected to a redox reaction at a pH between 7.2 and 8.4.

[0022] In one embodiment, the essential oil or carrier oil comprises hemp seed oil.

[0023] In one embodiment, the hemp seed oil is combined with the hemp extract, the hemp extract comprising 30% (w / w) to 95% (w / w) of the amount of the hemp oil composition.

[0024] In one embodiment, the cannabis extract is combined with an essential oil or a carrier oil, and the percentage concentration of the cannabis extract is between 7% (w / w) and 70% (w / w) of the amount of the cannabis oil composition.

[0025] In one embodiment, the method comprises the step of converting CBN (cannabinol) in the cannabis extract into THC (tetrahydrocannabinol) by isomerization.

[0026] In one embodiment, the method comprises the step of removing stems and / or seeds from the dried cannabis plant material prior to the step of eluting in a solvent.

[0027] According to another aspect of the present invention there is provided a method of preparing a cannabis oil composition substantially as described or illustrated herein. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The following description will be made with reference to the accompanying drawings, in which:

[0029] Figure 1 is a schematic diagram of the reflux and condensation stages of a method for preparing a cannabis oil composition according to one aspect of the present invention; Figure 2A-2C is a schematic diagram of the elution and filtration stage of the method for preparing a cannabis oil composition according to one aspect of the present invention;

[0030] Figure 3 is a schematic diagram of the distillation stage of a method for preparing a cannabis oil composition according to one aspect of the present invention;

[0031] Figure 4 is a schematic diagram of the redox reaction stage of the method for preparing a cannabis oil composition according to one aspect of the present invention;

[0032] Figure 5 is a schematic diagram of the infusion stage of a method for preparing a cannabis oil composition according to one aspect of the present invention; and

[0033] Figure 6 is a schematic diagram of representative process steps for preparing a cannabis oil composition according to one aspect of the present invention. DETAILED DESCRIPTION

[0034] Other features of the present invention are more fully described in the following description of several non-limiting embodiments. The description is only used to illustrate the purpose of the present invention to the technician. It should not be understood as a limitation to the summary, disclosure or description of the present invention as described above. In the accompanying drawings, the features of one or more exemplary embodiments are combined, and the same reference numerals are used to identify the same parts throughout.

[0035] Unless otherwise specifically stated, all technical and scientific terms used herein have the same meaning as those generally understood by those of ordinary skill in the art to which the present invention belongs. In addition, in the practice of the present invention, any method or material similar or equivalent to the method or material described herein may be used. For the purposes of the present invention, the following terms are defined.

[0036] The term "cannabis" generally refers to plants of the genus Cannabis, which includes sativa, cannabis, and wild cannabis plants. The term "species" refers to different variants of a particular plant genus. For example, the term "species" can refer to different types of cannabis plants. Different cannabis varieties often have different chemical compositions in terms of characteristic levels of cannabinoids and terpenes, as well as other components. The different cannabinoid and terpene profiles associated with different cannabis varieties can be used to treat different medical conditions.

[0037] The terms "treat," "treating," and "treatment" generally refer to any successful treatment or improvement of an injury, pathology, condition, or symptom (e.g., pain), including any objective or subjective factors, such as relief; remission; reduction of symptoms or making symptoms, injury, pathology, or condition more tolerable to the patient; reduction of the frequency or duration of symptoms or condition; or, in some cases, prevention of the onset of symptoms. The treatment or improvement of symptoms can be based on any objective or subjective factors, including, for example, the results of a physical examination.

[0038] The term "cannabis oil" generally refers to the mixture of compounds obtained from an extract of the cannabis plant. These compounds include, but are not limited to, cannabinoids, terpenes, terpenoids, and other compounds found in the cannabis plant. The exact composition of the cannabis oil will depend on the variety of cannabis being extracted, the extraction process itself and its efficiency, and any additives that may be added to alter the palatability of the cannabis oil or improve its administration.

[0039] The term "cannabinoid" generally refers to compounds that exhibit direct or indirect activity at cannabinoid receptors. There are two major cannabinoid receptors, CNR1 (also known as CB1) and CNR2 (also known as CB2). Other receptors that have been shown to have cannabinoid activity include the GPR55, GPR18, and TRPV1 receptors. The term "phytocannabinoid" refers to cannabinoids that are present in plant species or are derived from cannabinoids that are present in plant species. Examples of cannabinoids include, but are not limited to, tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV) and cannabigerol monomethyl ether (CBGM).

[0040] The term "acidic cannabinoid" generally refers to a cannabinoid having one or more carboxylic acid functional groups. Examples of acidic cannabinoids include, but are not limited to, tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). Acidic cannabinoids generally refer to the primary cannabinoids found in unprocessed, fresh, green (i.e., unprocessed) cannabis plant material. The term "neutral cannabinoid" refers to a cannabinoid without a carboxylic acid functional group. Examples of neutral cannabinoids include, but are not limited to, THC, CBD, CBG, CBC, and CBN.

[0041] As used herein, the term "cannabinoid profile" generally refers to the number, characteristics and quantity of cannabinoids in the preparation of cannabis oil. The cannabis oil composition of the present invention generally comprises a blend of at least two cannabis oil preparations with different cannabinoid profiles. In certain embodiments, a cannabinoid level that complies with regulations is provided in the composition by blending the cannabis oil preparations. When a certain amount (e.g., 75%) of a specific cannabinoid (e.g., THC) is derived from a specific cannabis oil preparation (e.g., the first cannabis oil preparation), the cannabinoid of the amount is referred to as "present in" the cannabinoid profile of the corresponding cannabis oil preparation. For example, when 75% of THC in the composition is present in the first cannabinoid profile, it means that 75% of THC in the final composition is derived from the first cannabis oil preparation in the composition. The remaining 25% of THC in the final composition is derived from other cannabis oil preparations (e.g., the second or third cannabis oil preparation) in the blend. It should be understood that after being blended into the composition, the characteristics of the cannabinoids will not remain different from each other, or be separated.

[0042] The term "reflux" generally refers to boiling or causing boiling by heating a solution for a period of time while continuously cooling the generated vapor back into the liquid so that the vapor returns to the original liquid after condensation. The term "degradation" generally refers to structural and / or chemical changes in a substance (e.g., THC (tetrahydrocannabinol)) or other plant components. Degradation can include, for example, changes in the chemical structure, oxidation state, or metal binding properties of a substance. The term "eluate" refers to the solution collected after refluxing / condensing the raw and completely dried cannabis plant material, which is maintained in the extract for a desired period of time during the processing. The eluate will contain dissolved cannabinoids and other compounds of medicinal value.

[0043] The term "filtrate" generally refers to a solution that has been passed through a membrane or filter of variable porosity or permeability to remove particulate matter or unwanted compounds. In the method of the present invention, the eluate is passed through a series of filters of varying grades to obtain a filtrate. The term "distillate" refers to a solution that has been concentrated by any known evaporation or distillation method. In the method of the present invention, the solvent is removed by evaporating the filtrate to prepare a cannabis composition or extract.

[0044] The term "fractionation" generally refers to the process of removing residual solvent from a cannabis composition by evaporation or otherwise by adding a small amount of water or ice. In the method of the present invention, the distillate can be concentrated by distillation and then the distillate (solvent) can be removed from the cannabis composition. Since water has a higher boiling point than the solvent, the residual solvent can be extracted first, leaving a pure cannabis composition or extract for subsequent use in the preparation of a cannabis oil preparation.

[0045] The term "extract" or "cannabis composition" generally refers to the remaining solution that has been dehydrated to remove residual solvents or water. In the methods of the present invention, the extract is formed by condensing and removing the evaporated distillate using any method known in the art. The term "essential oil" or "base oil" generally refers to a natural plant oil, usually obtained by steam / water distillation or by mechanical methods (such as cold pressing), which has a chemical composition and organoleptic properties (e.g., aroma, flavor or characteristics) unique to the plant or other source from which it is extracted.

[0046] The term "supercritical extraction" generally refers to an extraction method using pressurized gas (such as CO2) at ambient temperature. For example, CO2 extracts exhibit some characteristics of essential oils and absolutes. Like essential oils, they have many beneficial properties, but not all of them can be obtained by using solvent extraction. But unlike absolutes, they are not obtained by solvent extraction and are extracts similar to essential oils, but usually with a higher viscosity. They are similar to essential oils distilled by steam / steam in application and composition, but they contain more volatile components than extracts distilled by steam.

[0047] The term "redox reaction" generally refers to the process where two compounds are heated. For example, "cannabis" and water. By heating, the cannabis is oxidized (loses electrons), while the water is reduced (gains electrons) and evaporates into the atmosphere, leaving only the "cannabis". The term "colloidal silver water" generally refers to water produced using 99% pure silver electrodes that connect the positive and negative electrodes to a battery source within a specific time frame to obtain a certain ppm. For example, 1L of rainwater, charging a probe in the rainwater with a 12-volt battery for 1 hour, can obtain 40ppm.

[0048] In summary, the present invention provides a unique method for extracting cannabis oil compositions, wherein the preferred embodiment is a method of reflux condensation of any cannabis species using methylated spirits or similar denatured ethanol solvents, and the preferred embodiment is a method of preparing a cannabis oil composition for oral treatment using cannabis seed oil. In the first stage of the method, dried cannabis plant material is maintained in a solvent, and cannabinoids are extracted from the cannabis plant material by using a reflux / condensation method and using ice rather than water to condense the vapors within a specific time frame, and the solvent is maintained at a constant safe temperature.

[0049] The use of ice removes heat, effectively absorbing latent heat as well as heat energy caused by chemical reactions, and lowers the surface area to near 0°C internally, where this is the area where the vapor continues to condense and fall back into the solvent, keeping the solvent containing the cannabis material at a constant boiling temperature of 72-78°C to obtain an eluent. The eluent is then filtered through a series of screens to obtain a filtrate, as the cannabinoids have been extracted, exposing the cannabis plant material at this time.

[0050] The solvent is then extracted from the filtrate, using an additional distiller section, via the same reflux / condensation process as previously described, to produce a cannabis composition containing all of the cannabinoids, chlorophyll, waxes, sugars and a small amount of solvent residue. Once the extraction of solvent by distillation ceases, the cannabis oil composition remains containing all of the cannabinoids in liquid form at 72-78°C. At this stage of the process, fractional distillation is used to remove any residual solvent by adding water to the cannabis oil composition and evaporating it until it reaches 100% saturation with air. Once 100% saturation is reached, the water will not evaporate and the cannabis composition / water will then undergo another redox phase, which is an oxidation process.

[0051] This stage of the process is carried out within any specific time frame or predetermined time to produce various percentages of cannabinoids (CBN-cannabinol), degrading THC (tetrahydrocannabinol). When this stage is completed, it is then cooled to form a thick tar (cannabis composition), and in further embodiments, the process also includes a mixture of different ratios / percentages of cannabis oil composition / extract with essential oil (preferably cannabis seed oil).

[0052] According to the present invention, now refer to the attached Figure 1 , which shows the reflux and condensation stages of a method for preparing a cannabis oil composition according to one aspect of the present invention. Figure 1 A dual boiler arrangement is shown having an ice-cooled pool serving as a lid and a copper column for containing a cylindrical solid ice block for maximum cooling efficiency in reflux / condensation of the generated vapor which repeatedly drips back into the solvent and dried cannabis material, e.g., thousands of times over a specified period of time.

[0053] All parts are usually made of stainless steel, copper and brass, and all parts are welded with silver solder. In order to be able to extract cannabinoids from the cannabis material, a double hot plate 2 and an extended wire are used. The first pot 4 is filled with water 26 to 80 mm from the top of the stainless steel bracket 5, wherein the stainless steel bracket 5 is the internal support of the second pot 8. The water continues to boil, and the continuously boiling water is added to the first pot 4, and a certain water level is always maintained. The second pot 8 is filled with half of the dry cannabis material covered by the solvent 28. The second pot 8 is arranged inside the first pot 4, and the second pot 8 is sealed with packing 6A-6B around the top of the first pot 4, wherein a gap of 10 mm is left for exhausting steam. The first pot 4 and the second pot 8 are sealed with a PTFE garlock gasket (1 / 4 inch or 6.5 mm). Any desired size of PTFE garlock gasket can be used. The vent helps to reduce the water consumed by the continuous boiling and condensate escape of the first pot 4. A small amount of water can be added through the vent throughout the process. Inside the top of the second pot 8 containing the solvent and dry cannabis material is placed a conical reservoir 10 with ice, having an annular support for stability, and having rubber seals 12A-12B to reduce escaping smoke.

[0054] A centrally located drilled post support welded to the interior of the reservoir 10, the posts 14A-14B extend 100mm above the natural water level of the reservoir 10 to mark the steam flow. A 1 / 2 inch barb 16 is welded to the side of the reservoir 10 and the reservoir 10 is connected to a rubber hose 32 for excess water to flow out. Ice is continuously added to the reservoir 10 throughout the process. A 1 / 4 inch stainless steel needle valve 18 is connected to a 1 / 4 inch pipe welded to the posts 14A-14B just above the natural water level mark of the reservoir to relieve the pressure caused by the chemical reaction caused by heating the cannabis material in the solvent in the second pot 8. A 1 / 4 inch stainless steel outlet pipe 34 is connected to the ice cold water in the reservoir 10. Above the support post, an inverted 100mm copper cover 22 is provided. The copper cover 22 is welded to a 650 mm x 100 mm copper pipe column 24, wherein a 1 / 2 inch copper pipe 20 is welded to the top of the inverted copper cover 22 for draining water into the reservoir 10 when the ice melts. Inside the inverted 100 mm copper cover 22, a condensation cone is welded. The inverted copper cover 22 fits snugly on an extension of the support column, which is sealed by the weight of the solid ice 30 held in the copper pipe column 24. The 90 mm ice cubes are made in a 90 mm PVC rainwater pipe, which has a cap glued to one end, filled with water and frozen to obtain ice cubes. Once frozen, they are thawed, removed from the pipe, and stored in a refrigerator in their original state until they are used.

[0055] Now refer to the attached Figure 2A-2C , which shows the filtration stage of the eluate of the process for preparing a cannabis oil composition of one aspect of the present invention. The contents from the reflux and condensation stages are poured into the filter 40, the eluate 42 is allowed to drip into the first collection tank 44 while it is still warm, and the spent cannabis is discarded. The eluate 42 is further filtered into the second collection tank 46 while it is still warm through a 500 micron or 0.5mm first 35 stainless steel mesh 48 (316 grade) to obtain a first filtrate 50. The first filtrate 50 is further filtered through a 37 micron or 0.037mm second 400 stainless steel mesh 52 to remove finer cannabis particles and obtain a second filtrate 54 in a third collection tank 56 (this step may be optional). The second filtrate 54 is poured back to Figure 1 The second pot 8 of the reflux and condensation stage.

[0056] Now refer to the attached Figure 3 , which shows the distillation stage of the process for preparing a cannabis oil composition according to one aspect of the present invention. Figure 3 A small stainless steel tank 60 is shown inside the filter 62, wherein the filter 62 is placed between the second pot 8 and the water reservoir 10 containing ice for evaporating the solvent through a condensation / reflux column while maintaining the solvent at a constant temperature of 72-78°C to ultimately complete the extraction of the distillate (solvent) and the cannabis oil extract / water as the filtrate. As the second filtrate is refluxed into the second pot 8, the filter 62 is placed with rubber seals 64A and 64B molded to the top of the inside of the second pot 8. A small stainless steel tank 60 of approximately 1L is located in the center of the filter 62 for extracting the solvent. The water reservoir 10 and support ring are placed on top of the filter 62. The filter 62 has a rubber seal molded to the top to prevent fumes from being emitted into the atmosphere.

[0057] The support ring is located below the outer diameter of the reservoir 10, with its legs extending downward and around the outer diameter of the filter 62 and the second pot 8, for supporting the column. The 100mm copper pipe column 24 and the ice with the condensation cone are placed on the extension of the support column, which is set inside the reservoir 10. The solvent is continuously heated with a double boiler (i.e., boiling the water in the first pot 4), and the valve 18 is opened half a turn, allowing the steam pressure to be released from the pot 8 into the ice water in the reservoir 10. Most of the steam condenses and falls into the small stainless steel tank 60 located in the center of the filter 62 with the help of the condensation cone. It is manually removed using the correct PPE, while some of the condensed steam continues to fall back into the filtrate and continues to reflux. Water (e.g., 100mL) is added at the end of the solvent extraction to start a process called fractionation to remove any solvent remaining in the cannabis oil extract. Fractionation will continue until the air in the second pot 8 is completely saturated with moisture (100%), that is, this stage is over because the water will not continue to evaporate at this time.

[0058] In the preferred embodiment using ethanol, both water and ethanol have different boiling points, and the vapor pressure of ethanol removes any solvent residues from the residual cannabis oil extract / water prior to evaporation of the water redox reaction. Once all of the ethanol residue has been extracted, the contents of the second pot 8 (the cannabis oil extract / water combination) are added to a small 150-250 mL stainless steel can, which is further placed in a small amount of mineral oil bath and heated to the desired temperature to remove all traces of water from the cannabis oil extract by oxidation or redox reaction.

[0059] The cannabinoid oil extract is used in the preparation of a cannabis oil composition for oral treatment, unless CBN (cannabinol) needs to be formulated and THC (tetrahydrocannabinol) needs to be further reduced or completely removed. At this stage, the pH of the cannabis oil extract will reach 7.0 to 8.3, and all chlorophyll, waxes and sugars are still present when the process is completed using only ethanol.

[0060] Now refer to the attached Figure 4 , which shows the redox reaction stage of the preparation process of the cannabis oil composition according to one aspect of the present invention. A small stainless steel tank 90 containing the cannabis seed oil extracted from the second pot 8 after the fractionation stage is placed in a small amount of mineral oil bath 92, heated to the desired temperature using a hot plate 2, and the cannabinoids, i.e., tetrahydrocannabinol (THC), are evaporated by adding more water or colloidal silver water and longer time until there is no residual moisture in the cannabis seed oil extract.

[0061] In an exemplary embodiment, the cannabinoid oil extracted from Indian hemp and alfalfa hemp is subjected to a redox reaction. For different THC (tetrahydrocannabinol) formulas, the ratio of CBN (cannabinol) to be prepared depends on the different time intervals of the redox reaction (that is, the cannabinoid oil extract is oxidized by adding a certain amount of water or colloidal silver water and by evaporation). Those skilled in the art will be able to determine the ratio of THC / CBN required for certain medical requirements, which allows the cannabinoid oil extracts of these different ratios to be further used in the preparation method of the cannabis oil composition for oral treatment, and a small amount (e.g., 10 mL) of water or colloidal silver water is continuously added to the cannabis oil extract, and the water is continuously evaporated until the desired THC / CBN ratio is reached. For example, this can be measured by placing water in a measuring cup.

[0062] When the water is completely evaporated and becomes viscous when stirred, the cannabis oil extract begins to smoke. As water is added, the cannabis oil extract continues to evaporate (oxidize) and THC (tetrahydrocannabinol) degrades until the desired THC / CBN ratio is reached, or CBN and other cannabinoids are completely retained. THC continues to oxidize until it is completely exhausted, and CBN (cannabinol) is prepared. For technicians in the field of fluorescence measurement technology, THC reacts as follows under black light and shows a strong yellow-green color, while CBN reacts weakly and CBD does not react. In an exemplary embodiment, 0.1g of cannabis oil extract is added to a test tube and heated to 93°C with 0.5mL of petroleum ether or a similar solvent for 5 minutes. Evaporate the solvent on a boiling water bath to dry. After the solvent is completely evaporated, add 0.05mL of concentrated sulfuric acid. Cover the test tube, mix the residue / acid on a boiling water bath for 10 seconds, and cool it. Add 1mL of 20% ammonium hydroxide and check under a black light. When using a dropper, 1mL is equivalent to 2 drops.

[0063] A person skilled in the art may use chromatography, where a small amount of cannabis oil extract is dropped onto a thin layer of silica gel or alumina using a micropipette and placed on a plate. The plate is then placed in a small amount of solvent. The solvent is drawn to the other end by capillary action, which draws the cannabinoids present in the composition to different distances on the plate. The plate is then dried and sprayed with a plant dye that forms different colors with the various cannabinoids. A person skilled in the art may use gas chromatography. In this process, a small amount of cannabis oil extract is injected into a coil that is heated for a long time, a gas passes through the coil, and thousands of compounds leave the chromatographic column, which will show a series of irregular peaks on the gas chromatogram by detecting them at different times.

[0064] Now refer to the attached Figure 5, which shows the injection stage of the preparation process of the cannabis oil composition of one aspect of the present invention. An equal portion of the formulated cannabis oil extract and 95% ethanol are added to the first beaker 96 and heated to 78°C-80°C while stirring. The first beaker 96 is boiled in a small amount of water bath 100 on the heating plate 2. The second beaker 98 containing the base oil (e.g., hemp seed oil) is also heated to 78°C-80°C in the water bath 102. The first beaker 96 has a dissolved solution of the formulated desired cannabis oil extract, 95% ethanol in a liquid state, and the second beaker 98 has a base oil at 78°C-80°C, which are mixed together to form a cannabis oil composition for oral treatment.

[0065] The pH value of the cannabis oil composition is between 6.5 and 7.0. The person skilled in the art is aware of the density of the cannabis oil extract that needs to be formulated for further preparation of the cannabis oil composition to obtain the percentage / ratio required for oral treatment. The oral administration of the cannabinoids in liquid / droplet form is simply because the cannabinoids can immediately bind to the receptors within the endocannabinoid system of the human system and continue to bind to the area within the system that needs treatment.

[0066] Now refer to the attached Figure 6 , a flowchart of the blocks or steps of a method 110 for preparing a cannabis oil composition according to one aspect of the present invention is shown. The method 110 generally includes the following steps: by continuously refluxing dried cannabis plant material in a solvent for a predetermined time to elute 112 cannabinoids to obtain an eluate, filtering the eluate 114 using a series of filters to obtain a filtrate, extracting a distillate by condensing and evaporating 116 the solvent from the filtrate using a distiller, purifying 118 the distillate by a fractionation process to remove residual solvent, thereby obtaining a clean and non-toxic cannabis extract, subjecting the cannabis extract to a redox reaction 120 to completely remove water, and various percentages of CBN (cannabinol) can be prepared depending on the time range for the redox reaction, by degrading tetrahydrocannabinol (THC), combining the cannabis extract with an essential oil or a carrier oil 122 to obtain the cannabis oil composition, which is generally in the form of small droplets 124.

[0067] The method for preparing the cannabis oil composition may further include an isomerization stage. The process of converting CBD (cannabidiol) into THC (tetrahydrocannabinol) by using dilute acid. If necessary, further oxidation is performed by redox reaction to prepare different ratios of THC (tetrahydrocannabinol) / CBN (cannabinol).

[0068] The isomerization stage is only necessary when only cannabis plants with a high CBD content and a very low THC content are used. This is a very expensive and time-consuming process that can be avoided by choosing cannabis varieties with a higher THC content (such as Indian hemp, Sativa cannabis and / or hybrids of these two). For cannabis plants with high CBD (cannabidiol) and their compositions or extracts, isomerization is required to convert the CBD complex into a complex containing more TCH. Once converted to THC, it can be oxidized by the redox reaction as described above, and CBN is prepared by adjusting the degradation time of THC until the THC is completely exhausted.

[0069] Isomerization of CBD to THC is achieved by adding a small amount of acid to the oil (already extracted cannabis complex), for example, dissolving 10g (cannabis complex) in 200mL of solvent, followed by simple heating in 2mL of acid for 1 hour. When using alcoholic solvents, only 2mL of one of the following solutions should be added for every 200mL of solvent used: i. 120 grams of concentrated HCl slowly added to 900mL of water, or ii. 30mL of sulfuric acid slowly added to 1000mL of water. Once the isomerization is complete, the solvent is extracted using the reflux / condensation method. Although only a small amount of dilute acid is used, a small amount of baking soda is needed to neutralize the solvent before extraction. Add ice cubes and evaporate until the water is completely evaporated, as the solvent will evaporate first.

[0070] The extraction of the cannabinoids can be carried out alone or in combination with the isomerization and preparation of the cannabis oil extract (thick tar), depending on the content of THC and CBD and the type of cannabis used. Depending on the solvent used, large stems and seeds are removed from completely dried cannabis plants to obtain the best results in removing cannabinoids (possibly 90%-98% extraction). For freshly picked (fresh) cannabis plants, it is generally believed that THC and CBD exist in acidic form and are insoluble in certain solvents, and only 50% of the cannabinoids can be extracted. As will be appreciated by those skilled in the art, a wide variety of organic and inorganic solvents can work, but toxicity, flammability, availability and cost need to be considered. The following are examples of some typical solvents.

[0071] Chloroform - believed to be the best candidate solvent for extracting nearly 98% of all cannabinoids in dried cannabis material through the cannabis plant extraction method, but it has issues with high toxicity and flammability.

[0072] Light ether – It is believed that it can extract nearly 90% of all cannabinoids in dried cannabis material through the whole plant extraction method, but it also has the problem of high toxicity and flammability.

[0073] 95% Ethanol (Ethanol made from grains) - It is believed that it can extract nearly 90% of the total cannabis in dried cannabis material through the whole cannabis plant extraction method, and has low toxicity, the highest safety, and medium flammability.

[0074] 95% Denatured Ethanol - It is believed to be able to extract nearly 90% of the total cannabis in dried cannabis material through the whole cannabis plant extraction method and it has high toxicity / moderate flammability.

[0075] Isopropyl alcohol (70% isopropyl alcohol) - It is believed to extract nearly 90% of the total cannabis in dried cannabis material through the whole plant extraction method. It is moderately toxic and flammable.

[0076] Methanol (particularly industrial methanol which is explosive gas and highly toxic) - It is believed that it can extract nearly 90% of the total cannabis in dried cannabis material through the whole plant extraction method, but it has the problem of high toxicity and flammability.

[0077] Dichloromethane - It is believed to be able to extract nearly 90% of the total cannabis in dried cannabis material through the whole plant extraction method. It is non-flammable and has moderate toxicity.

[0078] Benzene – It is believed that it can extract nearly 90% of the total cannabis in dried cannabis material through the whole cannabis plant extraction method, and it is highly toxic and highly flammable.

[0079] Common organic solvents (such as benzene, chloroform, petroleum ether, etc.) cannot extract the water-soluble components of the cannabis (chlorophyll, waxes and sugars), while alcohol solvents can extract these chlorophyll, waxes and sugars, which are the key steps for collection during the extraction of the cannabis.

[0080] The reflux time, i.e. the predetermined time, needs to be adjusted accordingly according to the efficiency of the solvent, wherein chloroform and dichloromethane solvents only need to reflux for 0.5 hours, while ethanol, denatured ethanol or isopropanol need to reflux for at least 2 hours, but in order to maximize the extraction of all cannabinoids, preferably, reflux for 3-6 hours, preferably, reflux for 6 hours.

[0081] THC (tetrahydrocannabinol) continues to oxidize until it is completely exhausted, producing CBN (cannabinol). Oxidation of cannabis oil extracts to produce CBN (cannabinol) through a process called redox can only be performed when using indica and sativa cannabis or hybrids of the two. Wild cannabis species are rich in CBD (cannabidiol) unless isomerized, which mainly converts CBD (cannabidiol) into THC (tetrahydrocannabinol).

[0082] The pH of the cannabis oil extract needs to be between 7.0-8.6. The cannabis oil extract is in the form of a thick extract (once cooled it is a thick tar) with all the chlorophyll, waxes and sugars still present. The chlorophyll, waxes and sugars still present in the cannabis oil extract when the process is done with ethanol (alcohol) are a very important part of the present invention.

[0083] The following examples are used for immune system treatment by acting on CB2 receptors within the body's endocannabinoid system.

[0084] Residues, for example, use density 1.4

[0085] -1g divided by 1.4 (density) = 0.7142857%

[0086] -0.7142857% x 7g (cannabis oil extract or tar) = 4.99mL (cannabinoid oil)

[0087] -4.99 mL divided by 100 mL (hemp seed oil) = 0.0499%

[0088] -7g (hemp oil extract) + 7mL (95% ethanol) are mixed together and heated to 78-80°C, plus 100mL hemp seed oil (not light oil) also heated to 78-80°C. Once all ingredients of these two substances reach the required temperature, they need to be injected together.

[0089] The components of the cannabis oil composition in the infused dropperable form for oral treatment have a pH value between 6.5 and 7.0.

[0090] If one wishes to extract almost all of the cannabinoids, a cannabis oil composition can be obtained from the entire cannabis species, including hybrids, by using only dried cannabis material. For oil extracts of cannabis plants that are high in CBD (cannabidiol), isomerization is required to convert CBD (oil) to TCH (oil). Once converted to THC, oxidation can be performed as described above to degrade THC over different time periods until THC is completely depleted to produce CBN.

[0091] In an exemplary embodiment, 140g of 3-4 completely dried Indian hemp / varieties are blended into a second pot 8 with a total weight of (240g or 1 / 2 pound of dried cannabis material). 3L of methylated spirits (denatured ethanol consisting of 95% ethanol and 5% methanol) are added to the second pot 8 along with the cannabis material, just enough to cover the cannabis with some still spurting out. Both ingredients are at room temperature of 25°C. A reservoir 10 and support ring are mounted to the top of the second pot 8 to ensure that the rubber seal molded into the top of the second pot 8 can make a perfect cone seal to prevent the methylated spirit fumes from being emitted into the atmosphere. The support ring is located below the outer diameter of the reservoir and its legs extend downwardly and are set on the handle of the second pot 8, just to eliminate the possibility of column tilting and seal failure. A 100mm copper pipe column 24 is placed on the extension of the support column, which is set inside the reservoir 10.

[0092] Ice cubes are placed in the reservoir 10 and ice cubes (previously prepared) are placed in the 100 mm copper column 24. The hot plate 2 is heated to high temperature and the 6.5 hour reflux and condensation process is initiated. The 1 / 4 inch stainless steel needle valve 18 is opened half a turn to allow the pressure accumulated in the second pot 8 containing (solvent / cannabis material) to be discharged through the 1 / 4 inch pipe 34 to the bottom of the reservoir 10. At the same time, exhaust is initiated and the ice gradually melts and methylated spirit fumes are released into the water formed to suppress the fumes. The entire process is effectively started and operated for 1.5 hours to maintain a constant temperature, with ice being continuously added to the reservoir 10 and occasionally to the copper column 24. A length of 1 / 2 inch rubber hose 32 is connected to the brass barb 16 of the conical reservoir to drain excess water to grade or fill the now empty 90 mm PVC ice maker with chilled and frozen water.

[0093] The water in the first pot 4 is boiled between 100°C and 130°C and as water is gradually added, the methylated spirit / cannabis is also boiled inside the second pot 8, at a temperature between 73°C and 78°C. The vapors produced by the chemical reaction in the second pot 8 are continuously condensed and repeatedly refluxed, i.e., thousands of times over the next 6 hours, to extract all the cannabinoids, chlorophyll, sugars and waxes from the dried cannabis plant material. Throughout the process, the water reservoir 10 is kept full of ice. This is another essential and critical step, otherwise the solvent temperature will increase and burn. If necessary, additional water needs to be continuously added to the first pot 4 throughout the process.

[0094] Over the next 6 hours, while ice is filling the cylindrical / conical reservoir 10 and water is filling the first pot 4, an infrared laser thermometer gun may be used to take temperature readings from the outside. Monitor and record the temperature. As the ice decreases, the temperature may increase. Good ventilation is necessary and an intrinsically safe motor must be obtained if it is to be used nearby.

[0095] Table 1 below shows the conditions observed from the outside.

[0096]

[0097]

[0098] After 6.5 hours of reflux and condensation, the hot plate 2 is turned off. Since the first pot 4 is on the lower side, the solvent / cannabis material is still boiling. The cannabis material is taken out of the second pot 8 and placed in the filter 40, which is placed on top of the additional stainless steel collection tank 44 previously set aside. The 1 / 4 inch PTFE Garlock pad between the first pot 4 and the second pot 8 is removed to separate the two pots. The remaining solvent / cannabis material in the second pot 8 is poured into another stainless steel tank 44, wherein the filter 40 is set on top of it. The solvent is allowed to drip into the additional stainless steel collection tank 44 below the filter 40. The cannabis material solvent (eluate) in the stainless steel collection tank 44 is usually poured back into the second pot 8 only after passing through at least one of the two subsequent further filtration stages.

[0099] 1L of neat methylated spirit is poured onto the cannabis material in the filter 40 above the stainless steel tank 44 and all of the cannabis material / solvent is then returned to the second pot 8 which is still warm but then further filtered through at least one of two further filtering stages. The cannabis material may be squeezed to remove excess solvent and the waste cannabis material will be discarded as most of the cannabinoids have been extracted and are in the eluate. The filter 40 is removed and the remaining contents (eluate) is filtered through a 35 mesh 48 (316 grade (500 microns or 0.5mm)) into a stainless steel tank 46 to obtain a filtrate. The filtrate in the stainless steel tank 46 is poured very carefully / slowly through a 400 mesh 316 grade (27 microns or 0.037mm) back into the additional stainless steel collection tank 56. The second pot 8 is washed with water and dried. The second pot 8 is placed inside the first pot 4 which is set on an 80mm stainless steel stand 5. It is again sealed using a 1 / 4 inch PTFE Garlock gasket. The filtrate from the stainless steel collection tank 46 or 56 is added back to the second kettle 8 .

[0100] A filter 62 is placed inside the second pot 8. A stainless steel collection pot 60 of 1L capacity is placed in the center of the filter to collect the extracted solvent. A reservoir 10 and support ring are placed on top of the filter. Similar to the second pot 8, the filter has rubber seals 64A and 64B molded to the top of it. A cone seals inside the filter to prevent methylated spirit gas from escaping into the atmosphere. The legs of the support ring located below the outer diameter of the reservoir extend downwardly and fit neatly against the outer diameter of the filter 62 and the second pot 8 to support the column above. A 100mm copper column 24 is placed on an extension of the support column above 14A and 14B, which is set inside the reservoir 10. Ice cubes are placed in the reservoir 10 and ice cubes (previously prepared) are placed in the 100mm copper column 24.

[0101] The heating plate 2 is turned on and the distillation process begins. The external temperature is monitored over the next 2 hours while the ice column 24 and the water reservoir 10 are continuously filled with ice cubes. The temperature is monitored and recorded. As the ice is reduced, the temperature may increase. The following Table 2 shows the external and internal observations.

[0102]

[0103]

[0104] During the extraction process, the temperature of the methylated spirit is always 62°C. Prepare a lid for the pot. An infrared laser thermometer gun is used to measure the internal temperature of the extraction solvent and the filtrate below the filter. Take out the long copper tube column 24 with ice cubes and place the lid of the pot on the extension of the 100mm column support above 14A and 14B to suppress the solvent fumes. Remove the reservoir 10 and the support ring. Take out the 1L stainless steel collection tank 60 containing methylated spirit inside the filter 62 and pour the methylated spirit directly into the flask using a funnel. Read the temperature reading of the solvent. Quickly remove the filter and read the temperature reading of the filtrate (optionally). Its temperature is around 70°C-75°C.

[0105] Replace the filter with the stainless steel pot (1L capacity), the reservoir 10 and the support ring. Remove the lid of the pot 100mm inside the extension of the support above 14A and 14B and the reservoir 10. Now replace the long pipe column 24 with the ice cubes 30 still inside. Over the next 45 minutes, monitor the external temperature and add ice to the reservoir 10 and the short column of ice as needed. The first pot 4 is also topped up as needed. When another 45 minutes have passed, now a total of 90 minutes, the long copper pipe column 24 is again removed with the ice cubes and the lid of the pot is placed 100mm from the extensions 14A and 14B of the support columns to suppress solvent fumes. Remove the reservoir 10 and the support ring. Take out the 1L stainless steel collection pot 60 containing methylated spirits inside the filter and pour the methylated spirits directly into the flask using a funnel. About 1.5L of methylated spirits will be extracted. The stainless steel pot 60 (1L capacity), the reservoir 10, and the support ring are replaced again. The lid of the pot is removed from 100 mm inside the support extension above the reservoirs 14A and 14B. The long pipe column 24 is replaced with the ice cube 30 still inside. Over the next 30 minutes, the external temperature is monitored and ice is continuously added to the reservoirs and ice cubes as required.

[0106] Add a beaker containing 100 mL of distilled water to the second pot 8 containing the filtrate to start the fractionation. This can be done simply by removing the long tube column 24 with the ice cubes 30 still in it and pouring 100 mL of distilled water directly into the second pot 8 through the 100 mm support extensions 14A and 14B in the reservoir 10. Then replace the long tube column again with the ice cubes 30 still in it. During this 30 minute period, 2.1 L of methylated spirits should have been extracted. Now, add water to the second pot, and initially the external temperature of the first pot 4 will increase to 180°C and the temperature of the second pot 8 will increase to 60°C, draining the boiling water from the first pot. The temperature will eventually stabilize. This is because the water in the first pot 4 and the second pot 8 now have the same internal boiling temperature. This will remove any solvent residues in the filtrate in the second pot 8, leaving only water and cannabis oil extract. The external temperature is continuously monitored through the 45 minutes of fractionation. Monitor and record the temperature. The temperature may increase due to the reduction of ice.

[0107] Table 3 below shows the external and internal observation results.

[0108]

[0109] After 45 minutes of fractionation, the vapor pressure of the methylated spirits is higher than that of water, and any methylated spirit residue is drained from the filtrate and collected in a 1 L stainless steel collection tank in the filter. The water in the second pot 8 will not evaporate further due to its closed nature, and then an equilibrium is formed because the vapor space therein will be 100% saturated with water vapor. The cannabis oil extract still contains water and needs to undergo further redox reactions (oxidation). Fill the thin oil pot to 80% of its capacity with mineral oil 92 (e.g. motor oil).

[0110] A small stainless steel (150mL-250mL) pan of the cannabis oil extract still containing 100mL of water is carefully placed into a thin oil pan containing mineral oil. The redox reaction is initiated by reducing the water, which in turn oxidizes the cannabis oil extract. The thin oil pan (mineral oil bath) with a small stainless steel (150mL-250mL) pan 90 containing the cannabis oil extract is placed on the hot plate 2. The hot plate 2 is set to a temperature of 110°C-125°C in the mineral oil bath. The temperature can be monitored with an infrared laser thermometer gun. Once the mineral oil bath reaches the desired temperature between 110°C-125°C, the cannabis oil extract / water will remain slightly boiling between 95°C-106°C. The temperature is maintained for 75 minutes-90 minutes, with occasional stirring.

[0111] The cannabis oil extract gradually thickens while stirring. The small stainless steel (150mL-250mL) pan 90 containing the cannabis oil extract is removed from the mineral oil bath and the heating plate 2 is turned off. A small amount of water ice bath is reset to allow the cannabis oil extract to cool faster. Once the cannabis oil extract solidifies like tar, dig to the bottom with a measuring spoon to ensure that there is no water in the extract. If there is still a small amount of water in the cannabis oil extract, the small stainless steel (150mL-250mL) pan 90 containing the cannabis oil extract is placed back in the mineral oil bath and heated for another 30 minutes. The redox reaction continues until all the water is exhausted. The pan containing the cannabis oil extract is placed in an oil bath that is still hot enough to convert the cannabis oil extract back into a liquid. Once the cannabis oil extract returns to a liquid state, it can be placed in a glass bottle / beaker / bottle for storage, or further prepared into a droplet form for oral administration.

[0112] The cannabis oil extract will contain high concentrations of cannabinoids, including: THC (tetrahydrocannabinol) and CBD (cannabidiol) and small amounts of CBN (cannabinol) and CBG (cannabigerol). There will also be many other cannabinoids, along with chlorophyll, sugars and waxes. About 50g or more of the extract can be obtained by the method. From this point on, a large amount of CBN (cannabinol) can also be obtained by adding a measured amount of colloidal silver water and / or water to a small stainless steel (150mL-250mL) pan 90 and returning it to the frying pan (mineral oil bath) for continued heating.

[0113] The process can be continued for another 12 hours, carefully monitoring the temperature and continuously adding colloidal silver water and / or injecting water. At the end of the redox reaction stage, THC (tetrahydrocannabinol) will be converted into CBN (cannabinol) in large quantities, leaving very little THC (tetrahydrocannabinol). The cannabis oil extract, which is still in a liquid state, is weighed and then mixed with a base oil to obtain a cannabis oil composition of the desired proportion for oral administration, which is set at 5% in the following examples. 49g of the cannabis oil extract is poured into a first beaker 96. 49g of 95% pure ethanol is added to the first beaker 96 and stirred gently. 700g of hemp seed oil is placed in a second beaker 98. The second beaker containing the hemp seed oil is placed in a deeper pot 102, which has been filled with 50% of the water, and then placed on a hot plate 2 and heated to between 78°C and 80°C. This will require a slightly longer heating time.

[0114] A thin frying pan 100 filled with 80% water is placed on the heating plate 2 heated to 80°C and the first beaker 96 is placed in the water. The temperature is monitored using an infrared laser thermometer gun. Once the first beaker 96 and the second beaker 98 are at the desired temperature between 78°C and 80°C, the contents of the beaker 96 are added to the second beaker 98. It now needs to be stirred evenly to blend the two liquids together. The second beaker can now be poured into a 1L heat-resistant glass flask, covered with a lid and gently shaken. Due to the heating and gentle shaking, the lid on the heat-resistant glass flask needs to be gently shaken 3-4 times before it can be opened. Reduce the pressure appropriately. Now, the cannabis oil extract is infused with the base oil and cooled. This infused cannabis oil composition has 5% cannabinoids between pH 6.5 and 7.0. The cannabis oil composition needs to be stored at room temperature and away from light.

[0115] Alternatively, by using a funnel, the infused cannabis oil composition can be placed in a small medicine bottle with a dropper. This makes it easy to use it for oral treatment. The infused cannabis oil content is now about 5%, and one drop is equivalent to 0.05mL or 50mg. The dosage of 5% cannabis oil ratio includes the first 1-3 days = 5 drops per day (0.25mL = 250mg), the 4th-7th day = 8 drops per day (0.4mL = 400mg), the 8th-11th day = 12 drops per day (0.6mL = 600mg), the 12th-15th day = 15 drops per day (0.75mL-750mg).

[0116] The purpose of taking a large amount of low percentage cannabis oil in the form of drops is to enable the cannabinoids to attach to all receptors within the endocannabinoid system and inhibit foreign cells within the digestive system at high oil concentrations. More concentrated cannabis oil preparations can also be prepared, infusing a smaller amount of carrier oil, but still using the exact ratio of cannabis extract and 95% ethanol described in the previous examples. Weak preparations, which are less than the previous examples, are not recommended as they are considered useless, but can be prepared anyway with little benefit.

[0117] Example A (Immune System)

[0118] -1g divided by 1.4 (density) = 0.7142857%

[0119] -0.7142857% x 7g extract = 4.99

[0120] -4.99 divided by 100 mL (hemp seed oil) = 0.0499%

[0121] -4.99%

[0122] The above embodiments are believed to be effective for ovarian cancer and leukemia, severe osteoporosis, depression, spinal cancer, insomnia, Parkinson's disease, restless legs syndrome (to name just a few examples).

[0123] Example B-1 (can be used for multiple sclerosis)

[0124] -1g divided by 1.4 (density) = 0.7142857%

[0125] -0.7142857% x 7g extract = 4.99

[0126] -4.99 divided by 10 ml (hemp seed oil) = 0.499%

[0127] -49.9%

[0128] Example B-2 (Effective for multiple sclerosis)

[0129] -1g divided by 1.4 (density) = 0.7142857%

[0130] -0.7142857% x 7g extract = 4.99

[0131] -4.99 divided by 50 ml (hemp seed oil) = 0.998%

[0132] -9.98%

[0133] Example C

[0134] -1g divided by 1.4 (density) = 0.7142857%

[0135] -0.7142857% x 7g extract = 4.99

[0136] -4.99 divided by 50 ml (hemp seed oil) = 0.998%

[0137] -9.98%

[0138] Example D

[0139] -1g divided by 1.4 (density) = 0.7142857%

[0140] -0.7142857% x 7g extract = 4.99

[0141] -4.99 divided by 20 mL (hemp seed oil) = 0.2495%

[0142] -24.95%

[0143] Alternative embodiments of the present invention reside broadly in the parts, elements and features mentioned or indicated herein, either alone or together in any or all combinations of two or more parts, elements or features, and where specific integers mentioned herein have known equivalents in the art relevant to the invention, such known equivalents are deemed to be included herein as if individually set forth.

[0144] In the context of describing various embodiments (especially in the context of claimed subject matter), the use of the terms "a," "an," "said," "the," and / or similar designators should be interpreted to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. Unless otherwise indicated, the terms "including," "having," "comprising," and "containing" should be interpreted as open-ended terms (i.e., meaning "including, but not limited to,"). As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items. No language in the specification should be construed to indicate that any non-claimed subject matter is essential to the practice of the claimed subject matter.

[0145] The terms "about" and "approximately" used herein to modify numerical values ​​represent a close range around the explicit value. If "X" is the value, "about X" or "approximately X" will represent a value from 0.8 times to 1.2 times. Preferably, a value from 0.9 times to 1.1 times. More preferably, a value from 0.95 times to 1.05 times. Any reference to "about X" or "approximately X" specifically represents at least 0.95 times, 0.96 times, 0.97 times, 0.98 times, 0.99 times, 1.01 times, 1.02 times, 1.0 times, 1.04 times, and 1.05 times the value of X. Therefore, "about X" and "approximately X" are intended to teach and provide written description support for claim limitations such as "0.98 times".

[0146] Any method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order discussed or illustrated, unless specifically identified as an order of performance. It should also be understood that additional or alternative steps may be employed.

Claims

1. A method for preparing a cannabis oil composition, the method The following steps are involved: eluting cannabinoids from the dried cannabis plant material by refluxing the solvent for a predetermined period of time to obtain an eluate; filtering the eluate through a series of filters to obtain a filtrate; extracting a distillate by condensing and evaporating the solvent in the filtrate using a distiller; purifying the distillate by fractional distillation to remove residual solvent to obtain a cannabis extract; subjecting the cannabis extract to a redox reaction to remove water therefrom, thereby degrading tetrahydrocannabinol (THC) to produce CBN (cannabinol), the percentage concentration of CBN depending on the predetermined time of reflux; and The cannabis extract at the percentage concentration is mixed with essential oil or carrier oil to obtain a cannabis oil composition.

2. The method according to claim 1, wherein the cannabis plant material is selected from the non-exhaustive group consisting of an Indian cannabis plant, a wild cannabis plant, a Sativa cannabis plant and / or a hybrid cannabis plant.

3. The method of claim 1, wherein the solvent is selected from the non-exhaustive group consisting of chloroform, light ether, ethanol isopropanol, methanol, dichloromethane, benzene and denatured ethanol. The method according to claim 1 , wherein the predetermined time comprises a range of 0.5 hours to 8 hours. The method according to claim 1 , wherein the predetermined time is determined according to the type of solvent used.

6. The method according to claim 1, wherein the step of evaporating the solvent in the filtrate comprises the step of adding colloidal silver water to the filtrate.

7. The method of claim 1, wherein the step of evaporating the solvent by condensation is performed at a temperature of 72°C to 78°C.

8. The method of claim 1, wherein the step of performing the redox reaction comprises adding colloidal silver water to the cannabis extract to prolong the redox reaction and / or determine the percentage concentration of the cannabis extract.

9. The method of claim 1, wherein the cannabis extract is subjected to a redox reaction at a pH between 7.2 and 8.

4.

10. The method of claim 1, wherein the essential oil or carrier oil comprises hemp seed oil.

11. The method of claim 1 , wherein the hemp seed oil is combined with the hemp extract, the hemp extract comprising 30% (w / w) to 95% (w / w) of the amount of the hemp oil composition.

12. The method of claim 1, wherein the cannabis extract is combined with an essential oil or a carrier oil, and the percentage concentration of the cannabis extract is between 7% (w / w) and 70% (w / w) of the amount of the cannabis oil composition.

13. The method of claim 1, comprising the step of converting CBN (cannabinol) in the cannabis extract back to THC (tetrahydrocannabinol) by isomerization.

14. A method according to claim 1, wherein the method comprises the step of removing stems and / or seeds from the dried cannabis plant material prior to the step of eluting in a solvent.

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