Traditional Chinese medicine compound composition for promoting rapid taking in plateau

Abstract

The invention discloses a traditional Chinese medicine compound composition capable of promoting rapid taking in plateau, and belongs to the field of health food. Comprising fructus lycii, rhizoma polygonati, radix angelicae sinensis, lentinus edodes and tremella fuciformis. According to the formula, all the medicines are combined, and the effects of tonifying qi and benefiting blood are synergistically achieved based on the special plateau hypoxia environment. The medicine is orally taken 7-14 days before urgent entering the plateau, and the effect of promoting rapid taking in the plateau can be achieved.

Description

Technical Field

[0001] The present invention relates to the field of health food, and more specifically, to a compound composition of medicine and food for promoting rapid acclimatization to plateau. Background Art

[0002] As more and more people go to the plateau for scientific investigation, mission execution, and tourism, altitude sickness caused by rapid plateau entry has become an important constraint, and how to promote rapid plateau acclimatization has also become a hot topic. Drugs that promote acclimatization have disadvantages such as large side effects, and finding safe and effective ingredients is a good solution strategy.

[0003] Traditional Chinese medicine has had the theory of "medicine and food have the same origin" since ancient times. This theory believes that many foods are also medicines and can also prevent and treat diseases. The book "Huangdi Neijing Taisu" from the Tang Dynasty wrote: "Eating it on an empty stomach is food, and eating it with patients is medicine." The National Health Commission has successively announced a list of many traditional Chinese medicines that are both food and medicine, also known as dual-purpose ingredients for medicine and food, which currently has more than 100 species. It has the advantages of high safety and good patient compliance.

[0004] The root cause of altitude sickness is the low oxygen and low pressure plateau environment. According to traditional Chinese medicine theory, it occurs due to external infection and internal injury and is a syndrome of qi deficiency. Chinese medicine that replenishes qi and blood can be used to treat it.

[0005] Lycium barbarum was first recorded in "Shennong Bencao Jing". It nourishes the liver and kidneys, replenishes the essence and relieves fatigue, improves eyesight and calms the mind. Modern pharmacological research has shown that it has good effects in enhancing immunity, anti-inflammation, relieving visual fatigue, lowering blood sugar and blood pressure.

[0006] Polygonatum sibiricum is listed as a top-grade product in Shennong's Herbal Classics: Top-grade Plants. "Eating Polygonatum sibiricum regularly will ensure a lifetime of health." Ge Hong's Baopuzi: Inner Chapter Volume 11: Immortal Medicine says: "It obtains the energy of Kun soil and the essence of heaven and earth." Polygonatum sibiricum contains polygonatum sibiricum polysaccharides, polygonatum sibiricum saponins, flavonoids, lignans and other ingredients, which have multiple effects such as anti-aging, improving memory, and enhancing immunity.

[0007] Angelica sinensis is sweet, warm and neutral in nature. It has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is known as "Nine out of Ten Prescriptions are Angelica sinensis". In 2019, Angelica sinensis was listed as a medicinal and edible material. Angelica sinensis as a medicine was first seen in the "Shennong's Herbal Classic" in the Eastern Han Dynasty. The "Compendium of Materia Medica" in the Qing Dynasty recorded: "Angelica sinensis nourishes blood, moisturizes dryness, lubricates the intestines, is sweet and warm, is pungent and warm, disperses the inside, and is bitter and warm to help the heart and dispel cold; it enters the heart, liver, and spleen, and is a qi medicine in the blood." Angelica sinensis contains volatile oils, polysaccharides, organic acids, amino acids, flavonoids, trace elements, etc., which have the effects of protecting cranial nerves, relieving pain, improving immunity, and protecting after ischemia.

[0008] Shiitake mushrooms are the most representative medicinal and edible fungi. The Compendium of Materia Medica records that shiitake mushrooms are "sweet, mild, and non-toxic." Huang Fuji's "Compendium of Materia Medica" in the Qing Dynasty also records that "shiitake mushrooms are sweet and mild in nature, can replenish qi, help with eating, and relieve urinary incontinence." "Ben Jing Feng Yuan" records that shiitake mushrooms "greatly benefit the stomach qi." The National Compendium of Chinese Herbal Medicines records that shiitake mushrooms have the effects of replenishing qi and relieving hunger, curing wind and breaking blood, resolving phlegm and regulating qi, and benefiting flavor and helping with eating. Modern pharmacological research shows that it has anti-tumor, anti-viral, immunity-enhancing, anti-inflammatory, and antioxidant effects.

[0009] Tremella is a traditional Chinese edible fungus, rich in protein, dietary fiber, vitamins, minerals, chitin and other ingredients. "Shennong's Herbal Classic" records that Tremella is a precious nutritional tonic and a tonic for strengthening the body. Zhang Ren'an recorded in "Notes on the Drug Properties of Materia Medica" that Tremella "has the moistness of Ophiopogon japonicus without its coldness, and the sweetness of Polygonatum odoratum without its greasiness. It is a true lung-moistening and yin-nourishing medicine. It is comparable to ginseng, deer antlers, and bird's nests." Traditional Chinese medicine believes that Tremella is beneficial to the recovery of severe damage to vitality after illness, can improve women's postpartum weakness and general physical weakness, qi and yin deficiency, overwork, fatigue, and fatigue. It is a good medicine for those with weak spleen and stomach, lung deficiency and asthma, tasteless food, insufficient body fluids, and dry mouth. Summary of the invention

[0010] Based on the above analysis, the present invention provides a Chinese medicine compound that can be taken orally to promote rapid plateau acclimatization. The compound is composed of both medicinal and edible ingredients, has good safety, reasonable formulation, simple preparation method, wide source of raw materials, and has obvious effects of promoting acclimatization and resisting fatigue. The compound can significantly improve blood oxygen saturation and relieve altitude sickness if taken 7-14 days before entering the plateau.

[0011] The Chinese medicinal compound composition for promoting rapid plateau acclimatization provided by the present invention is prepared from the following raw materials in parts by weight.

[0012] 50-70 parts of wolfberry, 30-50 parts of polygonatum, 10-30 parts of shiitake mushrooms, 5-15 parts of angelica, and 0.5-1.5 parts of tremella polysaccharide.

[0013] Preferably, it is prepared from the following raw materials by weight: 60 parts of wolfberry, 40 parts of polygonatum, 20 parts of shiitake mushrooms, 10 parts of angelica, and 1 part of tremella polysaccharide.

[0014] Other advantages, objectives and features of the present invention will be embodied in part through the following description, and in part will be understood by those skilled in the art through study and practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a photo of the appearance of the Chinese medicine composition of the present invention

[0016] Figure 2 The anti-fatigue test results of the Chinese medicine composition of the present invention are DETAILED DESCRIPTION

[0017] The present invention will be further described in detail below in conjunction with the accompanying drawings so that those skilled in the art can implement the invention with reference to the description.

[0018] <Example 1> Preparation and Functional Evaluation of a Chinese Herbal Compound for Promoting Rapid Acclimatization to Plateau

[0019] Accurately weigh 3g Tremella polysaccharide, 3g Mogroside, and 30g Angelica sinensis, and add Angelica sinensis to Tremella polysaccharide and Mogroside powder in small amounts and multiple times; then weigh 60g Lentinus edodes, 120g Polygonatum sibiricum, and 180g Lycium barbarum, respectively, add them in sequence, and mix them thoroughly. Among them, Mogroside is used as a sweetener, and the rest are functional ingredients. The selected raw materials are all. The above-mentioned Chinese medicine compound composition is divided into 132 portions at a single dose unit of 3g. Its appearance is a brown powder ( Figure 1 ).

[0020] Experimental Example 1: Verification of the Anti-fatigue Effect of a Chinese Herbal Compound for Promoting Rapid Acclimatization at Plateau

[0021] Experimental animals: 8 Balb / c mice were divided into two groups, 4 mice in each group.

[0022] Experimental process: ① Suspension: Prepare the Chinese medicine compound composition according to the above method, and accurately weigh 50g, add 100mL deionized water, ultrasonically suspend, mix well and put it in a 4℃ refrigerator for use, and heat it in a water bath before use; ② Gavage: Give each mouse 0.2mL of suspension at a fixed time every afternoon (15:00-16:00) for 15 consecutive days; ③ Exhaustion experiment: 30min after gavage on the last day, the tail is loaded with a lead wire of 5% of the mouse's body weight for exhaustion experiment. When it sinks to the bottom of the water for 6-8s and does not float up, it is immediately fished out; ④ Sampling: After the mouse is fished out, it is quickly wiped dry, the eyeball is removed to take blood, muscle and liver, the blood sample is left at room temperature for 2h and then centrifuged, and the supernatant is taken for use; the muscle and liver are placed in a -80℃ refrigerator for testing; ⑤ Lactic acid detection: The serum is operated according to the instructions of the lactic acid detection kit and detected at 530nm on an enzyme reader ( Figure 2 ).

[0023] Experimental Example 2: Verification of the effect of Chinese herbal compound on promoting plateau acclimatization

[0024] Ten of the 20 people who were going to the plateau quickly were randomly selected to take 3g of the Chinese medicine compound composition in "Example 1" orally every day for 10 days before the departure date, and the other 10 people were used as the control group. The day of arrival at the plateau was recorded as day 0, and the blood oxygen saturation, heart rate, and blood pressure of the two groups of people were measured on days 0, 1, 3, 5, and 7, respectively. The differences in plateau acclimatization between the two groups were compared by subjective description of other symptoms such as headache, dizziness, fatigue and weakness, gastrointestinal reaction, etc., to evaluate the effect of the Chinese medicine compound composition in promoting rapid plateau acclimatization.

[0025] The results showed that after the group taking the Chinese medicine compound arrived directly at Lhasa at an altitude of 3,650 meters by plane, the overall plateau acclimatization ability was better, the headache symptoms were milder, and there was almost no gastrointestinal reaction such as diarrhea. On the third day, the overall performance was no different from that of the plain. The heart rate and blood pressure of the group not taking the Chinese medicine compound increased, and the blood oxygen saturation decreased. On the fifth day after the rapid entry into the plateau, the changes in vital signs reached a peak. Starting from the seventh day, the heart rate and blood pressure gradually decreased, and the blood oxygen saturation gradually increased. The results of blood oxygen saturation, heart rate, and blood pressure measurement of the above two groups at different times after the rapid entry into the plateau showed that the above indicators of the group taking the Chinese medicine compound were significantly improved (Table 1).

[0026] Table 1 Effect of Chinese herbal compound composition on promoting rapid acclimatization to plateau

[0027]

[0028]

Claims

1. The Chinese medicinal compound composition for promoting rapid plateau acclimatization provided by the present invention is prepared from the following raw materials in parts by weight: 50-70 parts of wolfberry, 30-50 parts of polygonatum, 10-30 parts of shiitake mushrooms, 5-15 parts of angelica, and 0.5-1.5 parts of tremella polysaccharide.

2. Preferably, it is prepared from the following raw materials by weight: 60 parts of wolfberry, 40 parts of polygonatum, 20 parts of shiitake mushrooms, 10 parts of angelica, and 1 part of tremella polysaccharide.

3. An orally active Chinese medicinal compound composition for promoting rapid plateau acclimatization according to any one of claims 1 to 2, characterized in that Choose Chinese herbal powder.

4. Use of the Chinese herbal compound composition according to any one of claims 1 to 2 in promoting rapid acclimatization to plateau.

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