Candesartan cilexetil cooling crystallization device and use method thereof

Abstract

The invention relates to the technical field of candesartan cilexetil production, and particularly discloses a candesartan cilexetil cooling crystallization device and a use method thereof. A candesartan cilexetil cooling crystallization device comprises a crystallization tank, a driving motor and a cooling device, a feeding pipe is inserted into the top of the crystallization tank, a discharging pipe is inserted into the bottom of the crystallization tank, the driving motor is arranged on the crystallization tank, an output shaft of the driving motor is connected with a driving rod, the driving rod is inserted into the crystallization tank, and the cooling device is arranged on the crystallization tank. And a plurality of stirring plates are mounted on the driving rod. The driving motor, the driving rod, the stirring plates and the like are arranged in the crystallization tank, the stirring plates are distributed on the driving rod at equal intervals, raw materials in the crystallization tank can be stirred under the driving of the driving motor, the temperatures of all the raw materials in the crystallization tank are the same, the crystallization speeds of all the raw materials are the same, and the crystallization time is more convenient to control.

Description

Technical Field

[0001] The invention belongs to the technical field of candesartan cilexetil production, and particularly relates to a cooling and crystallization device for candesartan cilexetil and a use method thereof. Background Art

[0002] Candesartan cilexetil is a drug used to treat hypertension and heart failure. It belongs to the class of angiotensin II receptor antagonists (ARBs) and dilates blood vessels and lowers blood pressure by blocking the binding of angiotensin II to its receptors. Candesartan cilexetil itself is a prodrug that is rapidly converted into the active metabolite candesartan in the body to exert its efficacy.

[0003] The crystallization of candesartan cilexetil is an important step in the crystal preparation process of candesartan cilexetil, through which candesartan cilexetil crystals can be obtained.

[0004] The existing preparation equipment has the following disadvantages in the process of cooling and crystallizing candesartan cilexetil:

[0005] First, since there is a large amount of candesartan cilexetil solution mixed in the storage tank, there is a regional deviation in the cooling device during cooling, which will lead to different raw material temperatures in different areas. This will result in different crystallization speeds of the raw materials in different areas, and the crystallization time is not convenient to control;

[0006] Secondly, during crystallization, as the raw material liquid level decreases, some candesartan cilexetil crystals do not fall to the bottom of the storage tank, but adhere to the inner wall of the stirring blade and the top of the tank, resulting in a decrease in the yield of candesartan cilexetil. Therefore, the present application proposes a cooling crystallization device for candesartan cilexetil and a method for using the same. Summary of the invention

[0007] The object of the present invention is to provide a cooling crystallization device for candesartan cilexetil and a method of using the same, so as to solve the problems raised by the above-mentioned background technology.

[0008] To achieve the above object, the present invention provides the following technical solution: a cooling crystallization device for candesartan cilexetil, comprising a crystallization tank, a driving motor, and a cooling device, wherein a feed pipe is plugged into the top of the crystallization tank, and a discharge pipe is plugged into the bottom of the crystallization tank, a driving motor is provided on the crystallization tank, an output shaft of the driving motor is connected to a driving rod, the driving rod is inserted into the interior of the crystallization tank, and a plurality of stirring plates are installed on the driving rod;

[0009] Position locking sleeves are installed on both upper and lower sides of the stirring plate, and a gap is provided between the position locking sleeve and the stirring plate, the gap is a lifting zone, and an elastic component is installed in the lifting zone;

[0010] A lifting guide is provided at the lower side of the stirring plate, and the lifting guide comprises a plurality of rising parts and falling parts;

[0011] The lifting guide is connected to the support frame;

[0012] A side wall crystal blowing assembly is installed on the stirring plate. The side wall crystal blowing assembly comprises a box body and an exhaust pipe, and the exhaust pipe is connected to an air pump.

[0013] Preferably, the bottom of the crystallization tank is provided with supporting legs, which are fixed to the tank wall of the crystallization tank by welding, and the driving motor is installed on the outer wall of the top of the crystallization tank through a motor bracket.

[0014] Preferably, the stirring plate comprises a mounting sleeve and a straight plate, wherein the straight plates are flushly distributed on both sides of the mounting sleeve, and the mounting sleeve is sleeved with a driving rod, wherein a driving portion is provided on the driving rod, and a protrusion is provided at the driving portion.

[0015] Preferably, the elastic component includes an elastic washer, which is received in the mounting groove, and the number of the rising part and the number of the falling part are four, and the rising part and the falling part are connected end to end.

[0016] Preferably, the support frame is located at the lower side of the lifting guide, the support frame is connected to the inner wall of the crystallization tank, and the upper end surface of the support frame is provided with an arc-shaped recessed portion, and the support frame is provided with a plurality of discharge ports in the area directly below the lifting guide, and the lower side of the support frame is abutted against a lower support plate, and the lower support plate is connected to the inner wall of the crystallization tank.

[0017] Preferably, the side wall crystal blowing assembly further comprises a top plate, the top of the box body is provided with an opening, and the top plate is sleeved with a rotating shaft inserted into the box body, and the rotating shaft is connected to a torsion spring.

[0018] Preferably, the lower end surface of the top plate is against the upper end surface of the trapezoidal plate, and the trapezoidal plate is arranged in a right-angled trapezoidal shape, and its hypotenuse is fitted with the lower end surface of the top plate, the trapezoidal plate is connected to the piston plate, the piston plate is connected to the moving block, the moving block is slidably connected to the inner wall of the cavity in the driving member, the moving block is connected to the spring, and an electromagnet is installed in the driving member.

[0019] A method for using a cooling crystallization device for candesartan cilexetil comprises the following steps:

[0020] 1. Feeding: feeding the solvent mixed with the crude product of candesartan cilexetil as a raw material from the feed pipe into the crystallization tank;

[0021] 2. Cooling and crystallization: Start the cooling device to cool down the raw materials in the crystallization tank. At the same time, start the driving motor to drive the driving rod and stirring plate to rotate, so that the temperature of the raw materials at all locations remains the same;

[0022] 3. Remove the crystals precipitated on the stirring plate: shake the stirring plate and use inertia to remove the crystals adhering to it;

[0023] 4. Remove the crystals adhered to the top of the inner wall of the crystallization tank: After the liquid level of the raw material drops to a height that does not touch the stirring plate, start the electromagnet, which pushes the moving block, the piston plate, and the trapezoidal plate to move, push the top plate upward, and leak the exhaust pipe in the box body. Then, start the air pump, and the airflow blown out from the exhaust pipe of the air pump can blow off the crystals adhered to the top of the inner wall of the crystallization tank and drop them to the bottom of the crystallization tank;

[0024] 5. Discharging: The crystals at the bottom of the crystallization tank, the crystals removed on the stirring plate and the crystals removed from the top of the inner wall of the crystallization tank are gathered together at the bottom of the crystallization tank and discharged from the discharge pipe.

[0025] Preferably, the method for shaking the stirring plate mentioned in step three is to allow the lower end surface of the stirring plate to rest against the rising part and the falling part on the lifting guide during the rotation. When it moves to the falling part, the stirring plate moves rapidly downward, and the stirring plate is separated from the crystals thereon under the action of inertia, and the crystals fall to the bottom of the crystallization tank.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. The present invention arranges a driving motor, a driving rod, a stirring plate and other components in the crystallization tank. The stirring plates are evenly spaced on the driving rod. Driven by the driving motor, the stirring plates can stir the raw materials in the crystallization tank to make the temperatures of the raw materials in each part of the crystallization tank the same. In this way, the crystallization speed of the raw materials in each part is the same, and the crystallization time is more convenient to control.

[0028] 2. The present invention arranges position locking sleeves on the upper and lower sides of the stirring plate, and a lifting area and an elastic component are arranged between the stirring plate and the position locking sleeve. During the rotation of the stirring plate, the outer wall of the lower end of the stirring plate is always in contact with the top of the rising part and the falling part of the lifting guide, and the falling part is distributed vertically downward. When the stirring plate rotates to the falling part, it will fall rapidly under the pressure of the elastic component and other components, and the stirring plate and the crystal are separated by inertia, thereby removing the crystal adhering to the stirring plate.

[0029] 3. The present invention arranges an exhaust pipe and an air pump on the stirring plate. The air pump can discharge airflow toward the inner wall of the crystallization tank through the exhaust pipe to blow off the crystals adhered to the top of the inner wall of the crystallization tank.

[0030] 4. The side wall crystal blowing assembly in the present invention comprises a box body and a top plate. When the raw material is stirred, the stirring plate contacts the raw material. At this time, the top plate blocks the opening at the top of the box body to prevent the exhaust pipe from directly contacting the raw material. When the crystal on the top of the inner wall of the crystallization tank needs to be removed, the electromagnet is started to drive the moving block to move to the left. When the moving block moves, it drives the trapezoidal plate to move to the left together. The hypotenuse of the trapezoidal plate can push the top plate to rotate around the center line of the rotating shaft. At this time, the box body is opened and the exhaust pipe is aligned with the inner wall of the crystallization tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a schematic structural diagram of the cooling and crystallization device of candesartan cilexetil in the present invention.

[0032] Figure 2 This is one of the internal structure schematic diagrams of the cooling and crystallization device of candesartan cilexetil in the present invention.

[0033] Figure 3 This is the second schematic diagram of the internal structure of the cooling and crystallization device of candesartan cilexetil in the present invention.

[0034] Figure 4 It is a schematic diagram of the structure of the stirring plate and the position locking sleeve in the present invention.

[0035] Figure 5 This is the third schematic diagram of the internal structure of the cooling and crystallization device of candesartan cilexetil in the present invention.

[0036] Figure 6 This is the fourth schematic diagram of the internal structure of the cooling and crystallization device of candesartan cilexetil in the present invention.

[0037] Figure 7 For the present invention Figure 6 Schematic diagram of the structure at A in the middle.

[0038] In the figure: 1, crystallization tank; 2, driving motor; 3, driving rod; 4, stirring plate; 5, position locking sleeve; 501, mounting groove; 6, elastic component; 7, lifting guide; 701, rising part; 702, falling part; 8, supporting frame; 801, arc-shaped concave part; 802, feeding port; 9, lower support plate;

[0039] 10. Feed pipe; 11. Discharge pipe; 12. Side wall crystal blowing assembly; 1201. Box body; 1202. Top plate; 1203. Rotating shaft; 1204. Exhaust pipe; 1205. Trapezoidal plate; 1206. Piston plate; 1207. Spring; 1208. Electromagnet; 1209. Air pump. DETAILED DESCRIPTION

[0040] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] Reference Figure 1-Figure 7A cooling crystallization device for candesartan cilexetil comprises a crystallization tank 1, a driving motor 2 and a cooling device. A support leg is provided at the bottom of the crystallization tank 1, and the support leg is fixed to the tank wall of the crystallization tank 1 by welding. A feed pipe 10 is plugged into the top of the crystallization tank 1, and a discharge pipe 11 is plugged into the bottom. A crude candesartan cilexetil is dissolved in a specific proportion of an acetone-petroleum ether mixed solvent, and the mixed raw material enters the crystallization tank 1 from the feed pipe 10. A driving motor 2 is provided on the crystallization tank 1. Specifically, the driving motor 2 is installed on the outer wall of the top of the crystallization tank 1 through a motor bracket. The output shaft of the driving motor 2 is connected to a driving rod 3. The driving rod 3 It is inserted into the crystallization tank 1, and a plurality of stirring plates 4 are installed on the driving rod 3. The stirring plates 4 include a mounting sleeve and a straight plate. The straight plates are evenly distributed on both sides of the mounting sleeve, and the mounting sleeve is sleeved with the driving rod 3. A driving part is provided on the driving rod 3, and a protrusion is provided at the driving part. The mounting sleeve and the protrusion can slide relatively up and down. When the mounting sleeve is sleeved with the protrusion, the protruding protrusion rotates with the driving rod 3, driving the mounting sleeve to rotate. The straight plate on the mounting sleeve stirs the raw materials in the crystallization tank 1, and the cooling device can reduce the temperature of the raw materials to cool the raw materials. After cooling, candesartan cilexetil in the raw materials will precipitate in the form of crystals.

[0042] When the stirring plate 4 rotates, it can stir the raw materials. During the cooling and precipitation process of the raw materials, some crystals will adhere to the outer surface of the stirring plate 4. The crystals adhered to the outer surface of the stirring plate 4 need to be removed. Therefore, position locking sleeves 5 are installed on the upper and lower sides of the stirring plate 4. A gap is set between the position locking sleeve 5 and the stirring plate 4. The gap is a lifting zone. An elastic component 6 is installed in the lifting zone. During the rotation of the stirring plate 4, the stirring plate 4 can be shaken up and down within the range of the lifting zone. The crystals adhered to it can be shaken off during the shaking process. The crystals remaining on the stirring plate 4 fall to the bottom of the crystallization tank 1 and are finally discharged from the discharge pipe 11.

[0043] Specifically, the elastic component 6 includes an elastic washer, which is received in the mounting groove 501. The mounting groove 501 is used to receive the elastic washer therein so that it is always in the mounting groove 501 during the process of being squeezed and rebounding. A lifting guide 7 is provided at the lower side of the stirring plate 4. The lifting guide 7 includes a plurality of rising parts 701 and falling parts 702. The rising part 701 is generally arranged in an arc shape, and the falling part 702 is arranged in a vertical shape. There are four rising parts 701 and four falling parts 702, and the rising parts 701 and the falling parts 702 are connected end to end. Two straight plates are provided in the stirring plate 4, so there are four rising parts 701 and four falling parts 702, and the two straight plates correspond to two rising parts 701 or falling parts 702 respectively, so that the left and right straight plates are lifted together when they are lifted, and fall together when they are dropped, and the movement is synchronized;

[0044] More specifically, the lifting guide member 7 is connected to the support frame 8, the support frame 8 is located at the lower side of the lifting guide member 7, the support frame 8 is connected to the inner wall of the crystallization tank 1, and the upper end surface of the support frame 8 is provided with an arc-shaped recessed portion 801, and the support frame 8 is provided with a plurality of discharge ports 802 in the area directly below the lifting guide member 7, and the lower side of the support frame 8 is abutted against a lower support plate 9, and the lower support plate 9 is connected to the inner wall of the crystallization tank 1.

[0045] The stirring plate 4 rotates driven by the driving motor 2, and moves along the rising part 701 and the falling part 702. Since the rising part 701 is lifted upward, the stirring plate 4 will be lifted upward during the rotation process until it reaches the position of the falling part 702, and it will fall directly. At this time, the stirring plate 4 moves downward, and the crystals thereon are separated from the stirring plate 4 under the action of inertia. The arc-shaped recessed part 801 provided on the support frame 8 is inclined downward and is configured as an arc surface as a whole. When the crystal falls on the support frame 8, it will move along the arc-shaped recessed part 801 on the support frame 8, and finally fall from the discharge port 802 and enter the bottom of the crystallization tank 1. Whether in the process of cleaning the crystals on the inner wall of the crystallization tank 1 or in the process of cleaning the crystals adhered to the stirring plate 4, the crystals falling on the support frame 8 can move along the arc-shaped recessed part 801 and fall from the discharge port 802.

[0046] Further, a side wall crystal blowing assembly 12 is installed on the stirring plate 4, and the side wall crystal blowing assembly 12 includes a box body 1201 and an exhaust pipe 1204. The exhaust pipe 1204 is connected to an air pump 1209, and the exhaust pipe 1204 is aligned with the inner wall of the crystallization tank 1. When the air pump 1209 in the side wall crystal blowing assembly 12 is started, the gas can be discharged from the exhaust pipe 1204. After being pressurized by the booster pump, the gas is blown toward the inner wall of the crystallization tank 1 at high pressure, and the crystals adhered to the inner wall of the crystallization tank 1 are blown off;

[0047] Specifically, the side wall crystal blowing assembly 12 also includes a top plate 1202, an opening is provided at the top of the box body 1201, and the top plate 1202 is sleeved with a rotating shaft 1203 inserted into the box body 1201, and the top plate 1202 will rotate with the rotating shaft 1203 during rotation, the rotating shaft 1203 is connected to a torsion spring, and the torsion spring is used to squeeze the rotating shaft 1203 and the top plate 1202, so that the top plate 1202 is in a state of covering the top opening of the box body 1201 when not subject to other forces, the lower end surface of the top plate 1202 is against the upper end surface of the trapezoidal plate 1205, and the trapezoidal plate 1205 is set to a right-angled trapezoidal shape, and its hypotenuse is in contact with the lower end surface of the top plate 1202, the trapezoidal plate 1205 is connected to the piston plate 1206, the piston plate 1206 is connected to the moving block, the moving block is slidably connected to the inner wall of the cavity in the driving member, the moving block is connected to the spring 1207, and an electromagnet 1208 is installed in the driving member.

[0048] Reference Figure 7When the electromagnet 1208 is started, it can drive the moving block to move to the side away from the driving member, that is, to the left side. When the moving block moves, it drives the trapezoidal plate 1205 to move to the left side together. The hypotenuse of the trapezoidal plate 1205 can push the top plate 1202 to rotate around the center line of the rotating shaft 1203. At this time, the box body 1201 is opened, and the exhaust pipe 1204 is aligned with the inner wall of the crystallization tank 1. When the electromagnet 1208 is closed, the spring 1207 pulls the trapezoidal plate 1205 back to its original position. Finally, the top plate 1202 covers the opening on the top of the box body 1201 under the action of the torsion spring, avoiding direct contact between the exhaust pipe 1204 and the raw materials in the crystallization tank 1, so that the crystals precipitated by the raw materials when they are cooled will not block the pipe mouth of the exhaust pipe 1204.

[0049] A method for using a cooling crystallization device for candesartan cilexetil comprises the following steps:

[0050] 1. Feeding: feeding the acetone-petroleum ether mixed solvent mixed with the crude product of candesartan cilexetil as a raw material from the feed pipe 10 into the crystallization tank 1;

[0051] 2. Cooling and crystallization: Start the cooling device to cool the raw materials in the crystallization tank 1. At the same time, start the driving motor 2 to drive the driving rod 3 and the stirring plate 4 to rotate, so that the temperature of the raw materials at all locations is kept the same, and the raw materials at all locations of the crystallization tank 1 are crystallized at the same time;

[0052] 3. Removing the crystals precipitated on the stirring plate 4: As the crystallization process proceeds, the liquid in the raw material gradually evaporates, the liquid level drops, and some crystals adhere to the stirring plate 4. As the stirring plate 4 rotates, the lower end surface of the stirring plate 4 abuts against the rising portion 701 and the falling portion 702 in the lifting guide 7. When the stirring plate 4 moves to the position of the falling portion 702, the stirring plate 4 moves downward rapidly. Under the action of inertia, the stirring plate 4 is separated from the crystals thereon, and the crystals fall to the bottom of the crystallization tank 1.

[0053] 4. Removing the crystals adhered to the top of the inner wall of the crystallization tank 1: The crystallization work continues. When the liquid level of the raw material drops to a height that does not contact the stirring plate 4, the electromagnet 1208 is started, which pushes the moving block, the piston plate 1206, and the trapezoidal plate 1205 to move, and pushes the top plate 1202 upward to leak the exhaust pipe 1204 in the box body 1201. After that, the air pump 1209 is started, and the airflow blown out from the exhaust pipe 1204 by the air pump 1209 can blow off the crystals adhered to the top of the inner wall of the crystallization tank 1 and drop them to the bottom of the crystallization tank 1;

[0054] 5. Discharging: The crystals at the bottom of the crystallization tank 1 , the crystals removed from the stirring plate 4 and the crystals removed from the top of the inner wall of the crystallization tank 1 are gathered together at the bottom of the crystallization tank 1 and discharged from the discharge pipe 11 .

[0055] Working principle:

[0056] Acetone-petroleum ether mixed solvent mixed with crude candesartan cilexetil is fed into the crystallization tank 1 from the feed pipe 10 as a raw material, and the cooling device and the drive motor 2 are started to cool down all parts of the raw material at the same time, so that crystals can be precipitated from the raw material;

[0057] When the stirring plate 4 rotates, it rests on the rising part 701 and the falling part 702 in the lifting guide 7. At the falling part 702, it can rely on inertia to separate from the crystals precipitated thereon, and the crystals fall to the bottom of the crystallization tank 1. When the liquid level of the raw material drops to a height that does not contact the stirring plate 4, the electromagnet 1208 is started, which pushes the moving block, the piston plate 1206, and the trapezoidal plate 1205 to move, and pushes the top plate 1202 upward, so that the exhaust pipe 1204 in the box body 1201 leaks out. After that, the air pump 1209 is started. The airflow blown out from the exhaust pipe 1204 by the air pump 1209 can blow off the crystals adhered to the top of the inner wall of the crystallization tank 1, and fall into the bottom of the crystallization tank 1, and finally the crystals are discharged from the discharge pipe 11.

[0058] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A cooling crystallization device for candesartan cilexetil, comprising a crystallization tank (1), a drive motor (2), and a cooling device, characterized in that: The top of the crystallization tank (1) is plugged with a feed pipe (10), and the bottom is plugged with a discharge pipe (11). The crystallization tank (1) is provided with a drive motor (2). The output shaft of the drive motor (2) is connected to a drive rod (3). The drive rod (3) is inserted into the crystallization tank (1), and a plurality of stirring plates (4) are installed on the drive rod (3); Position locking sleeves (5) are installed on both upper and lower sides of the stirring plate (4); a gap is provided between the position locking sleeve (5) and the stirring plate (4); the gap is a lifting zone, and an elastic component (6) is installed in the lifting zone; A lifting guide member (7) is provided on the lower side of the stirring plate (4), and the lifting guide member (7) includes a plurality of rising portions (701) and falling portions (702); The lifting guide member (7) is connected to the support frame (8); A side wall crystal blowing assembly (12) is installed on the stirring plate (4), and the side wall crystal blowing assembly (12) comprises a box body (1201) and an exhaust pipe (1204), and the exhaust pipe (1204) is connected to an air pump (1209).

2. A cooling crystallization device for candesartan cilexetil according to claim 1, characterized in that: The bottom of the crystallization tank (1) is provided with supporting legs, which are fixed to the tank wall of the crystallization tank (1) by welding, and the driving motor (2) is installed on the outer wall of the top of the crystallization tank (1) through a motor bracket.

3. A cooling crystallization device for candesartan cilexetil according to claim 1, characterized in that: The stirring plate (4) comprises a mounting sleeve and a straight plate, wherein the straight plates are evenly distributed on both sides of the mounting sleeve, and the mounting sleeve is sleeved with a driving rod (3), wherein a driving portion is provided on the driving rod (3), and a protrusion is provided at the driving portion.

4. A cooling crystallization device for candesartan cilexetil according to claim 1, characterized in that: The elastic component (6) comprises an elastic washer, which is received in the mounting groove (501). Four of the rising parts (701) and the falling parts (702) are provided, and the rising parts (701) and the falling parts (702) are connected end to end.

5. A cooling crystallization device for candesartan cilexetil according to claim 1, characterized in that: The support frame (8) is located at the lower side of the lifting guide member (7), the support frame (8) is connected to the inner wall of the crystallization tank (1), and the upper end surface of the support frame (8) is provided with an arc-shaped recessed portion (801), and the support frame (8) is provided with a plurality of discharge ports (802) in the area directly below the lifting guide member (7), and the lower side of the support frame (8) is abutted against a lower support plate (9), and the lower support plate (9) is connected to the inner wall of the crystallization tank (1).

6. A cooling and crystallization device for candesartan cilexetil according to claim 1, characterized in that: The side wall crystal blowing assembly (12) further comprises a top plate (1202), an opening is arranged at the top of the box body (1201), and the top plate (1202) is sleeved with a rotating shaft (1203) inserted into the box body (1201), and the rotating shaft (1203) is connected to a torsion spring.

7. A cooling and crystallization device for candesartan cilexetil according to claim 6, characterized in that: The lower end surface of the top plate (1202) is against the upper end surface of the trapezoidal plate (1205), and the trapezoidal plate (1205) is set to a right-angled trapezoidal shape, and its hypotenuse is in contact with the lower end surface of the top plate (1202). The trapezoidal plate (1205) is connected to the piston plate (1206), and the piston plate (1206) is connected to the moving block. The moving block is slidably connected to the inner wall of the cavity in the driving member, the moving block is connected to the spring (1207), and an electromagnet (1208) is installed in the driving member.

8. A method for using a cooling crystallization device for candesartan cilexetil, characterized in that: A method for using a cooling crystallization device for candesartan cilexetil as claimed in any one of claims 1 to 7, comprising the following steps:

1. Feeding: feeding a solvent mixed with a crude product of candesartan cilexetil as a raw material from a feed pipe (10) into a crystallization tank (1); 2. Cooling and crystallization: starting the cooling device to cool the raw materials in the crystallization tank (1), and at the same time, starting the driving motor (2) to drive the driving rod (3) and the stirring plate (4) to rotate, so that the temperature of the raw materials at all locations is kept the same; 3. Removing the crystals precipitated on the stirring plate (4): shaking the stirring plate (4) to remove the crystals adhering thereto by inertia; 4. Removing crystals adhering to the top of the inner wall of the crystallization tank (1): After the liquid level of the raw material drops to a height that does not contact the stirring plate (4), the electromagnet (1208) is started, which pushes the moving block, the piston plate (1206), and the trapezoidal plate (1205) to move, and pushes the top plate (1202) upward, so that the exhaust pipe (1204) in the box body (1201) leaks out. After that, the air pump (1209) is started, and the airflow blown out from the exhaust pipe (1204) by the air pump (1209) can blow off the crystals adhering to the top of the inner wall of the crystallization tank (1) and drop them to the bottom of the crystallization tank (1); 5. Discharging: The crystals at the bottom of the crystallization tank (1), the crystals removed from the stirring plate (4) and the crystals removed from the top of the inner wall of the crystallization tank (1) are gathered together at the bottom of the crystallization tank (1) and discharged from the discharge pipe (11).

9. The method for using the cooling and crystallization device of candesartan cilexetil according to claim 8, characterized in that: The method for shaking the stirring plate (4) mentioned in step three is to allow the lower end surface of the stirring plate (4) to abut against the rising part (701) and the falling part (702) on the lifting guide (7) during the rotation process. When the stirring plate (4) moves to the position of the falling part (702), the stirring plate (4) moves rapidly downward, and the stirring plate (4) is separated from the crystals thereon under the action of inertia, and the crystals fall into the bottom of the crystallization tank (1).

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