Insecticidal composition and application thereof

Abstract

The invention belongs to the technical field of pesticide compounding, and particularly relates to an insecticidal composition, the effective components of the insecticidal composition comprise an active component A and an active component B, the active component A is a compound represented by a formula (I), the active component B is a bisamide insecticide, and the mass ratio of the active component A to the active component B is 1: 50-65: 1. The composition disclosed by the invention has a synergistic effect under a certain proportion, and can effectively prevent and control multiple phytophagous pests, delay the generation of drug resistance of the pests and reduce the use amount of pesticides.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides and insecticides, and particularly relates to an insecticide composition and its application in preventing and controlling lepidopteran pests. Background Art

[0002] Diamide insecticides have high insecticidal activity and toxicological characteristics of preventing rapid feeding. Their mechanism of action is mainly to bind to ryanodine receptors (RyR), activate calcium ion channels, and rapidly release calcium ions in calcium stores. Calcium ions bind to troponin, causing sustained contraction of muscle fibers, causing insects to become paralyzed and stop feeding, ultimately leading to death from starvation.

[0003] In the actual process of agricultural production, the use of a single drug can easily lead to pest resistance. Diamide insecticides provide a new type of chemical means for the control of lepidopteran pests, but the problem of resistance is inevitable. Many lepidopteran pests have developed different levels of resistance to them, resulting in a decrease in field control effectiveness and an increase in dosage. The combination of two or more insecticides with different structures or different mechanisms of action can improve efficacy, reduce dosage, expand the control spectrum, delay the development of pest resistance, and extend product life. In most cases, the combination effect of pesticides is additive, and there are fewer real synergistic effects, especially those with very obvious synergistic effects and high co-toxicity coefficients.

[0004] After the inventors' compounding research, the compound represented by formula (I) was rationally compounded with flufenac, tolfenpyrad, tetrazobactam and cyantraniliprole, and surprisingly found that the insecticidal composition had a synergistic effect under a certain mass ratio, and there are no related reports on the compounding of the compound represented by formula (I) with flufenac, tolfenpyrad, tetrazobactam and cyantraniliprole. Summary of the invention

[0005] The purpose of the present invention is to provide an insecticide composition which has synergistic effect, reduces drug resistance, has low use cost and good prevention effect.

[0006] To achieve the above object, the technical solution adopted by the present invention is: an insecticide composition, wherein the active ingredients of the insecticide composition include active ingredient A and active ingredient B, and active ingredient A is a compound of formula (I), and the structural formula is as follows:

[0007] Active ingredient B is a diamide insecticide;

[0008] Furthermore, the diamide insecticide is selected from any one of flufenac, tolfenpyrad, tetrazobactam, and cyantraniliprole;

[0009] Furthermore, the mass ratio of the active ingredient A to the active ingredient B is 1:50 to 65:1;

[0010] Furthermore, the mass ratio of the active ingredient A to the active ingredient B is 1:35 to 50:1, or any value between the above values;

[0011] Furthermore, the mass ratio of the compound of formula (I) to flubendiamide is 1:25 to 35:1, such as 1:25, 1:15, 1:8, 9:2, 14:1, 24:1, 35:1;

[0012] Furthermore, the mass ratio of the compound of formula (I) to flubendiamide is 1:25 to 24:1.

[0013] Furthermore, the mass ratio of the compound of formula (I) to flubendiamide is 1:25, 1:15, 1:8, 9:2, 14:1, 24:1;

[0014] Furthermore, the mass ratio of the compound of formula (I) to tolfenpyrad is 1:30 to 30:1, such as 1:50, 1:30, 1:12, 3:2, 3:1, 6:1, 12:1, 30:1;

[0015] Furthermore, the mass ratio of the compound of formula (I) to tolfenpyrad is 1:30 to 12:1.

[0016] Furthermore, the mass ratio of the compound of formula (I) to tolfenpyrad is 1:30, 1:12, 3:2, 3:1, 6:1, 12:1;

[0017] Furthermore, the mass ratio of the compound of formula (I) to tetrazobactam is 1:28 to 50:1, such as 1:28, 1:14, 1:7, 3:1, 7:1, 15:1, 26:1, 50:1;

[0018] Furthermore, the mass ratio of the compound of formula (I) to tetrazolyl thiamethoxam is 1:14 to 15:1.

[0019] Furthermore, the mass ratio of the compound of formula (I) to tetrazobactam is 1:14, 1:7, 3:1, 7:1, 15:1;

[0020] Furthermore, the mass ratio of the compound of formula (I) to cyantraniliprole is 1:35 to 32:1; such as 1:35, 1:25, 1:13, 5:2, 13:1, 32:1, 65:1;

[0021] Furthermore, the mass ratio of the compound of formula (I) to cyantraniliprole is 1:25 to 32:1.

[0022] Furthermore, the mass ratio of the compound of formula (I) to cyantraniliprole is 1:25, 1:13, 5:2, 13:1, 32:1;

[0023] Furthermore, based on the total weight of the insecticide composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 0.5 to 90 wt%;

[0024] Furthermore, based on the total weight of the insecticide composition being 100 wt%, the sum of the content of the active ingredient A and the active ingredient B in the insecticide composition is 1 to 80 wt%;

[0025] The insecticide composition of the present invention can be prepared by a processing method known to those skilled in the art, that is, after mixing the active ingredient with a liquid solvent or a solid carrier, one or more of a surfactant such as a wetting agent, a dispersant, an emulsifier, a thickener, a disintegrant, an antifreeze agent, a defoaming agent, a solvent, a stabilizer, a penetrant and a carrier are added;

[0026] Further, the wetting agent is selected from a mixture of one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, lakai powder BX, wetting and penetrating agent F, sapodilla powder, silkworm feces or soapberry powder;

[0027] Further, the dispersant is selected from a mixture of one or more of polycarboxylates, lignin sulfonates, alkylphenol polyoxyethylene ether formaldehyde condensate sulfates, alkylbenzene sulfonate calcium, naphthalenesulfonic acid formaldehyde condensate sodium salts, alkylphenol polyoxyethylene ether phosphates, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene ethers or glycerol fatty acid ester polyoxyethylene ethers;

[0028] Furthermore, the emulsifier is selected from Nongru 500# (calcium alkylbenzene sulfonate), OP series phosphate ester (nonylphenol polyoxyethylene ether phosphate), 600# phosphate ester (phenylphenol polyoxyethylene ether phosphate), styrene polyoxyethylene ether ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, Nongru 400# (benzyl dimethylphenol polyoxyethyl ether), Nongru 700# (alkylphenol formaldehyde resin polyoxyethyl ether), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethylene ether), A mixture of one or more of the following: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 57, 58, 59, 61, 62, 63, 64, 65, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 101, 114, 115, 126, 130, 131, 132, 133, 134, 135, 136, 137

[0029] Furthermore, the thickener is selected from a mixture of one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;

[0030] Further, the disintegrant is selected from a mixture of one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;

[0031] Further, the antifreeze agent is selected from a mixture of one or more of ethylene glycol, propylene glycol, glycerol or urea;

[0032] Furthermore, the defoaming agent is selected from silicone oil, silicone compounds, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 A mixture of one or more fatty alcohol compounds;

[0033] Further, the solvent is selected from a mixture of one or more of N,N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;

[0034] Further, the stabilizer is selected from a mixture of one or more of epoxy soybean oil, epichlorohydrin, BHT, ethyl acetate, and triphenyl phosphate;

[0035] Further, the penetrant is selected from a mixture of one or more of penetrant JFC (fatty alcohol polyoxyethylene ether), penetrant T (diisooctyl maleate sulfonate), azone or silicone;

[0036] Further, the carrier is one, two or three of a solvent or a filler, and water is preferably deionized water;

[0037] Furthermore, the filler is selected from a mixture of one or more of kaolin, diatomaceous earth, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

[0038] The above substances are all commercially available.

[0039] The insecticidal composition of the present invention can be processed into any agriculturally acceptable dosage form;

[0040] Furthermore, the insecticide composition can be prepared into an agriculturally acceptable formulation, and the formulation is selected from a solid formulation and / or a liquid formulation;

[0041] Furthermore, the solid preparation includes powders, granules, pellets, tablets, strips, wettable powders, oil-dispersible powders, emulsion powders, water-dispersible granules, emulsion granules, water-dispersible tablets, soluble powders, soluble tablets or soluble granules;

[0042] Further, the liquid preparation includes a soluble solution, a soluble gel, an oil, a film-spreading oil, an emulsifiable concentrate, a latex, a dispersible liquid, an ointment, an aqueous emulsion, an oil emulsion, a microemulsion, a fat, a suspension, a microcapsule suspension, an oil suspension, a dispersible oil suspension, a suspoemulsion, a microcapsule suspension-suspension, a microcapsule suspension-water emulsion or a microcapsule suspension-suspoemulsion;

[0043] Furthermore, the solid preparation is selected from wettable powders and water dispersible granules; the liquid preparation is selected from emulsifiable concentrates, aqueous emulsions, microemulsions, suspensions, suspoemulsions, and dispersible oil suspensions;

[0044] Furthermore, the solid preparation is selected from wettable powders and water dispersible granules; the liquid preparation is selected from emulsifiable concentrates and suspensions.

[0045] The present invention also provides the use of the above insecticide composition in controlling lepidopteran pests;

[0046] Further, the lepidopteran pests include: Adoxophyes spp., Adoxophyes orana, Agrotis spp. (cutworm), Agrotis ipsilon (black cutworm), Alabama argillacea (cotton leafworm), Amorbia cuneana, Amyelosis transitella (navelorangeworm), Anacamptodes defectaria, Anarsia lineatella (peach twig borer), Anomis sabulifera (jute looper), Anticarsia g emma talis, Archips argyrospila (fruittreeleafroller), Archips rosana (rose leafroller), Agrotis spp. (black cutworm), Agrotis spp. (cotton leafworm), Amorbia cuneana, Amyelosis transitella (navelorangeworm), Anacamptodes defectaria, Anarsia lineatella (peach twig borer), Anomis sabulifera (jute looper), Anticarsia g emma talis, Archips argyrospila (fruittreeleafroller), Archips rosana (rose leafroller), Agrotis spp. (black cutworm ...grotis spp. (cotton leafworm), Agrotis spp. (cotton leafworm), Agrotis spp. (cotton leafworm), Agrotis spp. (cotton leafworm), Agrotis spp. leaf roller), Argyrotaenia spp. (tortricid moths), Argyrotaenia citrana (orange tortrix), Autographa gamma, Bonagota cranaodes, Borbo cinnara (rice leaf folder), Bucculatrix thurberiella (cotton leaf perforator), Caloptilia spp. (leaf miners), Capua reticulana, Carposina niponensis (peach fruit moth), Chilo spp., Chlumetia transversa (mango shoot borer), Choristoneura rosaceana (obliquebanded leaf roller),

[0047] leafroller), Chrysodeixis spp., Cnaphalocerusmedinalis (grass

[0048] leafroller), Colias spp., Conpomorpha cramerella, Cossus cossus (carpenter moth), Crambus spp. (sod webworms), Cydia funebrana (plum fruit moth), Cydia molesta (oriental fruit moth), Cydianignicana (pea moth), Cydia pomonella (codling moth), Darna diducta, Diaphania spp. (stem borers), Diatraea spp. (stalk borers), Diatraea saccharalis (sugarcane borer), Diatraea graniosella (southwester cornborer), Earias spp. (cotton bollworm), Earias insulata (Egyptian bollworm), Earias vitella (rough northern bollworm), Ecdytopophaaurantianum, Elasmopalpus lignosellus (lesser cornstalk borer), Epiphysias postruttana (light brown apple moth), Ephestia spp. (flour moths), Ephestia cautella (almond moth), Ephestia elutella (tobbaco moth), moth), Ephestia kuehniella (Mediterranean flour moth), Epimeces spp.), Epinotia aporema, Erionota thrax (bananaskipper), Eupoecilia ambiguella (grape berry moth), Euxoa auxiliaris (army cutworm), Feltia spp. (cutworms), Gortyna spp. (stemblerers), Grapholita molesta (Oriental fruit moth).

[0049] (oriental fruit moth), Hedylepta indicate (beanleaf webber), Helicoverpa sp p. (southworm), Helicoverpa armigera, Helicoverpa zea, Heliothis spp., Heliothis virescens, Hellula undalis (cabbage webworm), Indarbela spp. (root borers), Keiferia lycopersicella, Leucinodes orbonalis, Leucoptera malifoliella, Lithocollectis spp., Lobesia botrana (grape fruit moth), fruitmoth), Loxagrotis spp., Loxagrotis albicosta (western bean cutworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leaf miner), Mahasena corbetti (oil palm bagworm), Malacosoma spp.)(tent caterpillars), Mamestra brassicae(cabbage armyworm), Maruca testulalis(bean pod borer), Metisa plana, Mythimna unipuncta(true armyworm), Neoleucinodes elegantalis, Nymphula depunctalis, Operophtherabrumata, Ostrinia nubilalis(European corn borer), Oxydia vesulia, Pandemis cerasana(common currant tortrix), Pandemis heparana(brown apple tortrix), Papilio demodocus, Pectinophora gossypiella(pink bellworm), (bottomworm), Peridroma spp. (cutworm), Peridroma saucia (variegated cutworm), Perileucoptera coffeella (white coffee leafminer), Phthorimaea operculella (potato tuber moth), Phyllocnisitis citrella, Phyllonorycter spp., Pieris rapae, Plathypena scabra, Plodia interpunctella, Plutellaxylostella (diamondback moth), Polychrosis viteana (grapeberry moth), Prays endocarpa, Prays olive moth oleae) (olive moth), Pseudaletia spp.) (spodoptera), Pseudaletia unipunctata (armyworm), Pseudoplusia includes (, Rachiplusia nu, Scirpophaga incertulas, Sesamia spp. (stem borers), Sesamia inferens (pink rice stem borer), Sesamia nonagrioides, Setora nitens, Sitotroga cerealella (Angoumois grain moth), Sparganothis pilleriana, Spodoptera spp., Spodoptera exigua, Spodoptera fugiperda, Spodoptera oridania (southern armyworm), Synanthedon spp., Thecla basilides, Thermisia gemmatalis, Tineola bisselliella (webbing clothes moth), Trichoplusia ni (cabbage worm), Tuta absoluta;

[0050] Furthermore, the lepidopteran pests include Plutella xylostella, Spodoptera exigua, Spodoptera litura, Fall Armyworm, Chilo suppressalis, Cotton bollworm, and Pieris rapae.

[0051] The present invention also provides the above-mentioned insecticidal composition, which is applied to the pests to be controlled or the medium where they grow in an effective dose.

[0052] The beneficial effects of the present invention are:

[0053] 1) The insecticidal composition of the present invention has a significant control effect on lepidopteran pests at a certain mass ratio and has a synergistic effect;

[0054] 2) The insecticide composition of the present invention can significantly reduce the amount of pesticides used and delay the resistance of lepidopteran pests to diamide pesticides;

[0055] 3) The insecticide composition of the present invention reduces environmental pollution and is safe for humans and animals. DETAILED DESCRIPTION

[0056] The present invention is further described below with reference to the examples. The percentages in the examples are all percentages by weight, but the present invention is not limited thereto.

[0057] The insecticidal composition of the present invention can be provided in the form of a formulation. It can be prepared into a suspension, water dispersible granules, wettable powder, dispersible oil suspension, etc. as needed. The content of the active ingredient in the composition of the present invention depends on the application amount when used alone, and also depends on the mixing ratio and the degree of synergistic effect. The optimal range of the active ingredient content varies according to the formulation type of the composition.

[0058] Preparation Example

[0059] Preparation Example 1:

[0060] 22% Formula (Ⅰ) compound·flufenac suspension (18:4)

[0061] Preparation formula: 18% of the compound of formula (I), 4% of flufenac, 3.5% of polyoxyethylene ether nonionic (D1109S), 3% of phenethylphenol polyether phosphate salt, 1% of naphthalenesulfonate (2020), 2% of sodium dioctyl sulfosuccinate, 1.2% of magnesium aluminum silicate, 0.25% of xanthan gum, 4.5% of glycerol, 0.02% of benzisothiazolinone, 0.5% of organosilicon defoamer, and the balance is made up of deionized water;

[0062] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in a reactor in sequence, water is added to mix evenly, and the suspension is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0063] Preparation Example 2

[0064] 18% formula (Ⅰ) compound·toluamide suspension (13:5)

[0065] Preparation formula: 13% of the compound of formula (I), 5% of tolfenpyrad, 3% of polyoxyethylene ether nonionic (D1109S), 3% of phenethylphenol polyether phosphate salt, 4% of dodecyl polyoxyethylene ether phosphate, 1.2% of magnesium aluminum silicate, 0.25% of xanthan gum, 4.5% of glycerol, 0.02% of potassium sorbate, 0.5% of organosilicon defoamer, and the balance is made up of deionized water;

[0066] Preparation method: Same as Preparation Example 1.

[0067] Preparation Example 3

[0068] 28% formula (Ⅰ) compound·tetracycline amide suspension (21:7)

[0069] Preparation formula: 21% of the compound of formula (I), 7% of tetrazolyl amide, 3% of phenethylphenol polyether phosphate salt, 2.5% of sodium dioctyl sulfosuccinate, 2% of polyoxyethylene ether nonionic (D1109S), 1.2% of magnesium aluminum silicate, 0.25% of xanthan gum, 4.5% of glycerol, 0.02% of potassium sorbate, 0.5% of organic silicon defoamer, and the balance is made up of deionized water;

[0070] Preparation method: Same as Preparation Example 1.

[0071] Preparation Example 4

[0072] 28% formula (Ⅰ) compound·cyantraniliprole suspension (20:8)

[0073] Preparation formula: 20% of the compound of formula (I), 8% of cyantraniliprole, 2.5% of castor oil polyoxyethylene ether (110), 3% of phenethylphenol polyether phosphate salt, 2% of sodium dioctyl sulfosuccinate, 1.2% of magnesium aluminum silicate, 0.25% of xanthan gum, 4.5% of glycerol, 0.02% of benzisothiazolinone, 0.5% of organosilicon defoamer, and the balance is made up of deionized water;

[0074] Preparation method: Same as Preparation Example 1.

[0075] Preparation Example 5

[0076] 8% formula (Ⅰ) compound·tetrazobactam dispersible oil suspension (7:1)

[0077] Preparation formula: 7% of the compound of formula (I), 1% of tetrazobactam, 2% of succinate sulfonate, 12% of alkyl aryl polyoxyethylene polyoxypropylene ether, 3% of fatty alcohol polyoxyethylene ether, 3% of calcium dodecylbenzene sulfonate, 1.5% of silicon dioxide, 0.5% of organic bentonite, 15% of 200# solvent oil, and the balance is made up of methyl oleate;

[0078] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in a reactor in sequence, and solvent oil is added to mix evenly. After high-speed shearing, wet sand grinding, and finally homogenous filtration, the dispersible oil suspension product is obtained.

[0079] Preparation Example 6

[0080] 47% formula (Ⅰ) compound·cyantraniliprole wettable powder (32:15)

[0081] Preparation formula: 32% of the compound of formula (I), 15% of cyantraniliprole, 4.5% of alkyl naphthalene sulfonate (Morwet EFW), 4% of block copolymer dispersant (D-800), 3% of sodium alkyl polyoxyethylene ether sulfonate, 3.5% of sodium lignin sulfonate, and kaolin to make up the balance;

[0082] Preparation method: Active ingredients, other functional adjuvants and fillers are mixed according to the formula ratio, stirred evenly in a stirring kettle, and ground and mixed evenly for multiple times by a jet mill to prepare the wettable powder of the composition of the present invention.

[0083] Preparation Example 7

[0084] 42% Formula (Ⅰ) compound·Fluchlorfenapyr water dispersible granules (32:10)

[0085] Preparation formula: 32% of the compound of formula (I), 10% of flubendiamide, 7% of sodium lignin sulfonate (WG4), 7% of naphthalene sulfonate formaldehyde condensate, 2% of sodium dodecyl sulfate, 4.5% of white carbon black, 20% of starch, and kaolin as the balance;

[0086] Preparation method: According to the formula ratio of the embodiment, the active ingredient is added to the carrier, and a surfactant and other functional additives are added thereto, mixed, and after air flow pulverization, 10-25% of water is added, and then kneading, granulation, drying and sieving are performed to obtain a water-dispersible granule product.

[0087] Preparation Example 8

[0088] 50% formula (Ⅰ) compound·toluamide water dispersible granules (35:15)

[0089] Preparation formula: 35% of the compound of formula (I), 15% of tolfenpyrad, 7.5% of sodium lignin sulfonate (WG4), 8.5% of naphthalene sulfonate formaldehyde condensate, 2% of sodium lauryl sulfate, 5% of white carbon black, 24% of starch, and kaolin to make up the balance;

[0090] Preparation method: Same as Preparation Example 7.

[0091] Indoor biological activity assay:

[0092] The specific test methods are as follows:

[0093] Lepidoptera larvae: a combination of leaf and insect dipping;

[0094] Test insect age: Use sensitive populations raised indoors for multiple generations, and select healthy and uniform Lepidoptera 2nd instar larvae (≥60 per treatment).

[0095] Experimental treatment: Use tweezers to place fresh cabbage slices in the drug solution and immerse them for 10 seconds, then take them out. After the drug solution dries naturally, place the cabbage slices in a culture dish lined with moisturizing filter paper. After placing the test insects in the drug solution for 5 seconds, use filter paper to absorb the excess drug solution and place the test insects in a culture dish with leaves immersed in the corresponding concentration.

[0096] Each treatment was repeated 4 times, and the blank treatment was used as the control. The treated test insects were placed in an artificial intelligence culture room at 26±1°C, a light period of L:D=16h:8h, and a relative humidity of 60% for breeding.

[0097] After treatment with the pesticide, the mortality of the test insects was investigated at 48 hours. The criterion for judging the death of the test insects was obvious shrinkage of the insect body or inability to crawl normally after being pricked with a needle. The number of dead insects was recorded.

[0098] Data statistics and analysis:

[0099] According to the survey data, the adjusted mortality rate of each treatment was calculated using the following formula:

[0100]

[0101] Where:

[0102] P——mortality rate, in percentage (%);

[0103] K——indicates the number of dead insects, in units of heads;

[0104] N——represents the total number of insects treated, in heads.

[0105]

[0106] Where:

[0107] P1——adjusted mortality rate, in percentage (%);

[0108] P t ——Treatment mortality rate, expressed as percentage (%);

[0109] P0——blank control mortality rate, in percentage (%).

[0110] Data statistics and analysis: If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be made; if the control mortality rate is greater than 20%, the test needs to be repeated.

[0111] The data were processed by probability value analysis and analyzed by DPS statistical analysis system to obtain the toxicity regression line, LC 50 The activity of the test agent on the biological test material was evaluated by using the value, 95% confidence limit and correlation coefficient r.

[0112] The co-toxicity coefficient (CTC value) of the mixture is calculated as follows:

[0113]

[0114] Where:

[0115] ATI——Actual Toxicity Index of Mixture;

[0116] S——LC of standard pesticide 50 , the unit is milligrams per liter (mg / L);

[0117] M——LC of the mixture 50 , the unit is milligrams per liter (mg / L).

[0118] TTI=TI A * P A +TI B * P B

[0119] Where:

[0120] TTI – Theoretical Toxicity Index of Mixtures;

[0121] TI A ——A: toxicity index of the agent;

[0122] P A ——The percentage of agent A in the mixture, in percentage (%);

[0123] TI B ——Toxicity index of agent B;

[0124] P B ——The percentage of agent B in the mixture, in percentage (%).

[0125]

[0126] Where:

[0127] CTC – Co-toxicity coefficient;

[0128] ATI——Actual Toxicity Index of Mixture;

[0129] TTI - Theoretical Toxicity Index of Mixture.

[0130] The co-toxicity coefficient of the combination CTC≥120 shows a synergistic effect; CTC≤80 shows an antagonistic effect; 80<CTC<120 shows an additive effect.

[0131] Indoor activity measurement of Plutella xylostella

[0132] As shown in Table 1, flubendiamide has a high toxicity to Plutella xylostella, and its LC 50 The LC of the compound of formula (I) against Plutella xylostella is 0.394 mg / L. 50 It is 9.036mg / L.

[0133] When the weight ratio of the compound of formula (I) and flufenac to Plutella xylostella is 1:25 to 35:1, the co-toxicity coefficient is greater than 120, and the mixture of the two shows a synergistic effect within this weight ratio range; when the weight ratio of the compound of formula (I) and flufenac to Plutella xylostella is 1:25 to 24:1, the co-toxicity coefficient is greater than 140, which has an obvious synergistic effect.

[0134] Table 1 The results of the toxicity test of the compound of formula (I) and flubendiamide against Plutella xylostella

[0135]

[0136] As shown in Table 2, tolfenpyrad has a high toxicity to Plutella xylostella, and its LC 50 The LC of the compound of formula (I) against Plutella xylostella is 1.505 mg / L. 50 It is 9.036mg / L.

[0137] When the weight ratio of the compound of formula (I) and tolfenpyrad to Plutella xylostella is 1:50-30:1, the co-toxicity coefficient is greater than 80, and the two exhibit additive or synergistic effects when mixed within the range of 1:50-30:1, without antagonism; when the weight ratio of the compound of formula (I) and tolfenpyrad to Plutella xylostella is 1:30-30:1, the co-toxicity coefficient is greater than 130, and the two exhibit synergistic effects when mixed within this weight ratio range.

[0138] Table 2 The results of the toxicity test of the compound of formula (I) and tolfenpyrad against Plutella xylostella

[0139]

[0140] Indoor activity test of Pieris rapae

[0141] As shown in Table 3, tetrazobactam has a high toxicity to Pieris rapae, and its LC 50 The LC of the compound of formula (I) against Pieris rapae is 0.456 mg / L. 50 It is 12.776mg / L.

[0142] When the weight ratio of the compound of formula (I) and tetrazopyram to Pieris rapae is 1:28 to 50:1, the co-toxicity coefficient is greater than 120, and the mixture of the two exhibits a synergistic effect within this weight ratio range.

[0143] Table 3 Toxicity test results of the compound of formula (I) and tetrazopyram against Pieris rapae

[0144]

[0145] As shown in Table 4, cyantraniliprole has a high toxicity to Pieris rapae, and its LC 50The LC of the compound of formula (I) against Pieris rapae is 0.590 mg / L. 50 It is 12.776mg / L.

[0146] When the weight ratio of the compound of formula (I) and cyantraniliprole to Pieris rapae is 1:35-65:1, the co-toxicity coefficient is greater than 80, and the two mixed in the range of 1:35-65:1 show additive or synergistic effects, and no antagonistic effect occurs; when the weight ratio of the compound of formula (I) and cyantraniliprole to Pieris rapae is 1:35-32:1, the co-toxicity coefficient is greater than 120, indicating that the two mixed in this weight ratio range show a synergistic effect.

[0147] Table 4 Toxicity test results of the compound of formula (I) and cyantraniliprole against Pieris rapae

[0148]

[0149] Field Trial on Controlling Diamondback Moth

[0150] Test crops: cauliflower (Qingsong 65);

[0151] Test target: Diamondback moth;

[0152] Test reference: Based on GB / T 17980.13-2000 "Guidelines for field efficacy tests (I): Insecticides for the control of lepidopteran larvae of cruciferous vegetables";

[0153] Test location: Experimental field of cruciferous vegetable planting base in Shuiquan Village, Shilibao Town, Miyun District, Beijing;

[0154] Application equipment: 3WBS-16 electric backpack sprayer;

[0155] Experimental crops: Cauliflower was planted on July 20, 2023, with a row spacing × plant spacing of 0.5m × 0.3m; the cultivation conditions of all experimental plots were uniform, with the same fertilizer and water management level, relatively good water and fertilizer conditions, and sticky loam;

[0156] Test time: September 2, 2023 (cauliflower rosette stage);

[0157] Test drug:

[0158] Table 5 Field test design and dosage

[0159]

[0160] Test method: Apply the pesticide once during the peak period of diamondback moth infestation.

[0161] Plot size and repetition: random block arrangement, plot size 20m 2 , each treatment was repeated 4 times.

[0162] Survey method: Five random sampling points were taken in each plot, and two cauliflower plants were fixed with signs at each point to investigate the number of diamondback moths on the whole cauliflower plant. The base number of insects was investigated before spraying, and the number of remaining insects was investigated 3d and 7d after spraying.

[0163] Calculation formula and data analysis:

[0164]

[0165] Test results:

[0166] The results in Table 6 show that 3 days after application, 22% of the compound of formula (I)·flufenac suspension (18:4) and 18% of the compound of formula (I)·toluamide suspension (13:5) showed good rapid effect on Plutella xylostella, with the protective effects being 86.51% and 86.17%, respectively, which were significantly higher than the control single agent.

[0167] Table 6 Field control effect of different pesticides on Plutella xylostella (3 days after application)

[0168]

[0169] Note: The above insect population base and control efficacy data are the average of 4 replicates, and the values ​​are rounded to two decimal places. Different letters after the control efficacy data in the same column indicate significant differences (P < 0.05).

[0170] The results in Table 7 show that 7 days after application, 22% of the compound of formula (I)·flufenac suspension (18:4) and 18% of the compound of formula (I)·toluamide suspension (13:5) showed good persistence against Plutella xylostella, with the protective effects being 91.66% and 90.87%, respectively, which were significantly higher than the control single agent.

[0171] Table 7 Field control effects of different pesticides on Plutella xylostella (7 days after application)

[0172]

[0173] Note: The above insect population base and control efficacy data are the average of 4 replicates, and the values ​​are rounded to two decimal places. Different letters after the control efficacy data in the same column indicate significant differences (P < 0.05).

[0174] Safety: During the test period and later observations, cauliflower grew normally and no obvious pesticide damage was observed.

[0175] Field Trial on Controlling Cabbage Lobelia

[0176] Experimental crops: Cabbage (cabbage), which was in the rosette stage during the experiment;

[0177] Test target: Pieris rapae;

[0178] Test reference: Based on GB / T 17980.13-2000 "Guidelines for field efficacy tests (I): Insecticides for the control of lepidopteran larvae of cruciferous vegetables";

[0179] Test location: Cabbage test field at the cruciferous vegetable planting base in Biejiatun Village, Anqiu City, Weifang City, Shandong Province;

[0180] Application equipment: 3WBS-16 electric backpack sprayer;

[0181] Trial date: July 12, 2023;

[0182] Experimental environment: All experimental plots had uniform cultivation conditions, the same fertilizer and water management level, good water and fertilizer conditions, and sticky loam;

[0183] Test drug:

[0184] Table 8 Field test design and dosage

[0185]

[0186] Test method: Apply the pesticide once during the peak period of cabbage looper occurrence (mostly 2nd to 4th instar).

[0187] Plot size and repetition: random block arrangement, plot size 20m 2 , each treatment was repeated 4 times.

[0188] Survey method: Randomly sample five points in each plot, hang a sign on 4 cabbages at each point, investigate the number of cabbage loopers on all cabbages, investigate the base number of insects before applying pesticides, and investigate the number of remaining insects 3d and 14d after applying pesticides.

[0189] Calculation formula and data analysis:

[0190]

[0191] Test results:

[0192] The results in Table 9 show that 3 days after application, 28% of the compound of formula (I)·tetrazobactam suspension concentrate (21:7) and 28% of the compound of formula (I)·cyantraniliprole suspension concentrate (20:8) showed good rapid effect on cabbage loopers, with the prevention effects being 88.19% and 86.23%, respectively, which were significantly higher than the control single agent.

[0193] Table 9 Field control effect of different pesticides on cabbage worms (3 days after application)

[0194]

[0195] Note: The above insect population base and control efficacy data are the average of 4 replicates, and the values ​​are rounded to two decimal places. Different letters after the control efficacy data in the same column indicate significant differences (P < 0.05).

[0196] The results in Table 10 show that 14 days after application, 28% of the compound of formula (I)·tetrazobactam suspension concentrate (21:7) and 28% of the compound of formula (I)·cyantraniliprole suspension concentrate (20:8) showed good persistence against cabbage loopers, with the protective effects being 94.85% and 93.68%, respectively, which were significantly higher than the control single agent.

[0197] Table 10 Field control effect of different pesticides on cabbage worms (14 days after application)

[0198]

[0199]

[0200] Note: The above insect population base and control efficacy data are the average of 4 replicates, and the values ​​are rounded to two decimal places. Different letters after the control efficacy data in the same column indicate significant differences (P < 0.05).

[0201] Safety: During the test period and later observations, cabbage grew normally and no obvious pesticide damage was observed.

[0202] Although the application describes specific embodiments in detail by means of examples, the disclosure of the application may adopt various modifications and alternative forms. However, it should be understood that the disclosure of the application is not limited to the disclosed specific forms. On the contrary, the disclosure of the application covers all modifications, equivalents and alternative forms within the scope of the disclosure of the application, and the scope of the application is limited by the attached claims and their legal equivalents.

Claims

1. An insecticidal composition, characterized in that: The active ingredients of the insecticide composition include active ingredient A and active ingredient B. Active ingredient A is a compound of formula (I) with the following structural formula: Active ingredient B is a diamide insecticide.

2. The insecticidal composition according to claim 1, characterized in that The diamide insecticide is selected from any one of flubendiamide, tolfenpyrad, tetrazobactam and cyantraniliprole.

3. The insecticidal composition according to claim 1, characterized in that The mass ratio of the active ingredient A to the active ingredient B is 1:50 to 65:1; Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:35 to 50:

1.

4. The insecticidal composition according to claim 1, characterized in that The mass ratio of the compound of formula (I) to flufenac is 1:25-35:1, the mass ratio of the compound of formula (I) to tolfenpyrad is 1:30-30:1, the mass ratio of the compound of formula (I) to tetrazolyl thiophanate is 1:28-50:1, and the mass ratio of the compound of formula (I) to cyantraniliprole is 1:35-32:1; Preferably, the mass ratio of the compound of formula (I) to flufenac is 1:25-24:1, the mass ratio of the compound of formula (I) to tolfenpyrad is 1:30-12:1, the mass ratio of the compound of formula (I) to tetrazobactam is 1:14-15:1, and the mass ratio of the compound of formula (I) to cyantraniliprole is 1:25-32:

1.

5. The insecticidal composition according to claim 1, characterized in that: Based on the total weight of the insecticide composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the insecticide composition is 0.5 to 90 wt%; Preferably, the total content of the active ingredient A and the active ingredient B in the insecticide composition is 1 to 80 wt %.

6. The insecticidal composition according to claim 1, characterized in that The insecticide composition also includes an adjuvant, which is selected from one or more of a wetting agent, a dispersant, an emulsifier, a thickener, a disintegrant, an antifreeze agent, a defoaming agent, a solvent, a stabilizer, a penetrant and a carrier.

7. The insecticidal composition according to claim 6, characterized in that The insecticide composition is prepared into a formulation form permitted in agriculture, and the formulation form is selected from a solid formulation and / or a liquid formulation; Preferably, the solid preparation is selected from wettable powders and water-dispersible granules; the liquid preparation is selected from emulsifiable concentrates, aqueous emulsions, microemulsions, suspensions, suspoemulsions, and dispersible oil suspensions.

8. Use of the insecticidal composition according to any one of claims 1 to 7 in controlling agricultural, forestry or horticultural herbivorous pests.

9. The use according to claim 8, characterized in that The herbivorous pests are lepidoptera pests; Preferably, the lepidopteran pests include Plutella xylostella, Spodoptera exigua, Spodoptera litura, Spodoptera frugiperda, Chilo suppressalis, Cotton bollworm, and Pieris rapae.

10. The use according to claim 8, characterized in that The insecticide composition is applied to the pests to be controlled or the medium where they grow at an effective dose.

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