Traditional Chinese medicine composition for lowering lipid, dispelling melancholy and promoting coronary circulation as well as paste and preparation method of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for lowering lipid, dispelling melancholy and dredging vessels as well as a paste and a preparation method thereof, which can solve the problems that the existing symptomatic treatment medicine has different degrees of side effects and is not remarkable in curative effect. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 8-15 parts of vinegar-processed radix bupleuri, 8-15 parts of fried white paeony root, 8-10 parts of fried fructus aurantii, 8-11 parts of radix paeoniae rubra, 18-25 parts of radix rehmanniae recen, 8-10 parts of fried peach kernel, 8-15 parts of angelica sinensis, 9-12 parts of fructus trichosanthis, 3-6 parts of liquorice, 8-10 parts of ligusticum wallichii, 8-12 parts of lignum dalbergiae odoriferae, 12-18 parts of madder, 6-15 parts of prepared rehmannia root, 8-15 parts of poria cocos, 8-15 parts of achyranthes root, 8-15 parts of radix curcumae, 12-18 parts of semen cassiae, 12-18 parts of raw hawthorn, 8-15 parts of chrysanthemum, 26-35 parts of raw The traditional Chinese medicine is prepared from 6-11 parts of semen boitae, 8-12 parts of semen pruni, 8-15 parts of raw coix seeds, 5-8 parts of turtle shells, 6-10 parts of raw pollen typhae, 12-18 parts of endothelium corneum gigeriae galli, 15-25 parts of raw lily bulbs, 8-15 parts of folium mori and 12-18 parts

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, and in particular to a traditional Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, a paste thereof and a preparation method thereof. Background Art

[0002] Metabolic associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease, refers to a liver metabolic disease characterized by excessive fat deposition in liver cells, in addition to fatty liver disease caused by long-term heavy drinking and other clear liver-damaging factors. The disease has become the most common chronic liver disease in the world, often accompanied by obesity, type 2 diabetes, hyperlipidemia, hypertension, insulin resistance, etc. It can increase the risk of atherosclerosis, accelerate the occurrence of cardiovascular and cerebrovascular diseases, chronic kidney disease, cirrhosis, liver and extrahepatic malignancies, and seriously endanger human health. At present, the treatment of MAFLD is mainly symptomatic treatment through lifestyle changes (diet, exercise), weight loss surgery, and taking pioglitazone, metformin, statins, vitamin E and other drugs. However, the problems with these existing symptomatic treatment drugs are that they have side effects to varying degrees and the efficacy is not significant. Summary of the invention

[0003] The purpose of the present invention is to solve the technical problems that existing symptomatic treatment drugs have side effects of varying degrees and have insignificant therapeutic effects, and to provide a Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians, and a paste thereof and a preparation method thereof.

[0004] The inventive concept of the present invention is as follows:

[0005] Professor Yang Zhen is the fourth National Master of Traditional Chinese Medicine. Inspired by the academic thoughts of Mr. Wang Xinwu, the inheritor of Danxi School, and Mr. Ma Ruiting, the successor of Huang Yuanyu, the imperial physician of the Qing Dynasty, he proposed the "Theory of Xianghuo Qi Movement", and innovatively proposed the "Six Types of Xianghuo (including Xianghuo of stagnant heat, Xianghuo of damp heat, Xianghuo of stasis heat, Xianghuo of blood heat, Xianghuo of yin deficiency, and Xianghuo of deficiency and decline)" and "Five Theories on Liver Treatment", which supplemented the deficiencies of the Xianghuo theory in treatment classification and improved the theory of liver physiology and pathology in traditional Chinese medicine.

[0006] Professor Yang Zhen consulted ancient and modern literature and combined clinical practice to believe that MAFLD belongs to the category of "liver malnutrition" and "blood turbidity syndrome". Professor Yang Zhen believes that the cause of MAFLD is improper diet and imbalance between work and rest, which leads to pathological products such as phlegm, dampness, blood stasis, and accumulation that damage the liver and spleen together, the liver fails to release, the spleen fails to function properly, dampness and blood stasis are endogenous, and stagnation turns into heat, so that phlegm, blood stasis and heat are stagnated in the liver and various internal organs and cause the disease. The disease is located in the liver, and often involves the spleen, stomach, kidney, heart, etc., with a mixture of deficiency and excess. At the same time, he innovatively proposed to treat this disease with the "phase fire qi mechanism theory". The pathogenesis is summarized as liver meridian stagnation and heat, and blood stasis in the meridians. When treating, pay attention to the words "heat" and "stasis".

[0007] Professor Yang Zhen developed an empirical prescription "Sangming Decoction" for "non-alcoholic fatty liver disease" based on his many years of clinical experience. The present invention takes "Sangming Decoction" as the basic prescription, combines it with a number of classic prescriptions, and makes additions and subtractions to obtain a Chinese medicine composition, which has the effects of clearing the liver and lowering lipids, removing blood stasis and dredge meridians, regulating qi and relieving depression, etc. It is widely used in clinical practice with significant therapeutic effects.

[0008] In order to achieve the above invention objectives and complete the above invention concepts, the present invention adopts the following technical solutions:

[0009] A Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, which is special in that it comprises the following raw materials in parts by weight:

[0010] 8-15 parts of vinegar bupleurum, 8-15 parts of stir-fried white peony root, 8-10 parts of stir-fried fructus aurantii, 8-11 parts of red peony root, 18-25 parts of raw rehmannia root, 8-10 parts of stir-fried peach kernel, 8-15 parts of angelica root, 9-12 parts of whole trichosanthes root, 3-6 parts of licorice root, 8-10 parts of chuanxiong, 8-12 parts of dalbergia odorifera, 12-18 parts of madder root, 6-15 parts of cooked rehmannia root, 8-15 parts of tuckahoe, 8-15 parts of cyperus rotundus, 8-15 parts of turmeric, 1 part of cassia seed 2-18 parts, raw hawthorn 12-18 parts, chrysanthemum 8-15 parts, raw astragalus 26-35 parts, wolfberry 18-23 parts, Cistanche 12-18 parts, polygonatum 6-12 parts, pine nuts 6-11 parts, Prunus mume seeds 8-12 parts, raw coix seeds 8-15 parts, turtle shell 5-8 parts, raw pollen 6-10 parts, chicken gizzard 12-18 parts, raw lily 15-25 parts, mulberry leaves 8-15 parts, black plum 12-18 parts.

[0011] Furthermore, the weight parts of each raw material drug are:

[0012] 8-12 parts of vinegar bupleurum, 8-12 parts of stir-fried white peony root, 8-10 parts of stir-fried fructus aurantii, 8-11 parts of red peony root, 18-24 parts of raw rehmannia root, 8-10 parts of stir-fried peach kernel, 8-12 parts of angelica root, 9-11 parts of whole trichosanthes root, 3-5 parts of licorice root, 8-10 parts of chuanxiong, 8-12 parts of dalbergia odorifera, 12-15 parts of madder root, 6-12 parts of cooked rehmannia root, 8-12 parts of tuckahoe, 8-12 parts of cyperus rotundus, 8-12 parts of turmeric, 1 part of cassia seed 2-16 parts, raw hawthorn 12-15 parts, chrysanthemum 8-12 parts, raw astragalus 28-35 parts, wolfberry 18-22 parts, Cistanche 12-16 parts, polygonatum 6-10 parts, pine nuts 6-10 parts, Prunus mume seeds 8-11 parts, raw coix seeds 8-12 parts, turtle shell 5-8 parts, raw pollen 6-10 parts, chicken gizzard 12-16 parts, raw lily 15-24 parts, mulberry leaves 8-12 parts, black plum 12-16 parts.

[0013] Furthermore, the weight parts of each raw material drug are:

[0014] 9 parts of vinegar bupleurum, 9 parts of stir-fried white peony root, 9 parts of stir-fried fructus aurantii, 9 parts of red peony root, 20 parts of raw rehmannia root, 9 parts of stir-fried peach kernel, 9 parts of angelica, 10 parts of whole trichosanthes root, 4 parts of liquorice, 9 parts of ligusticum chuanxiong, 9 parts of dalbergia odorifera, 15 parts of madder, 8 parts of prepared rehmannia root, 9 parts of tuckahoe, 9 parts of rhizoma cyrtonemae, 9 parts of curcuma, 15 parts of cassia seed, 15 parts of raw hawthorn, 9 parts of chrysanthemum, 30 parts of raw astragalus, 20 parts of wolfberry, 15 parts of cistanche, 8 parts of polygonatum, 9 parts of cypress seed, 10 parts of prunes, 9 parts of raw coix seed, 6 parts of turtle shell, 9 parts of raw pollen, 15 parts of chicken gizzard lining, 20 parts of raw lily, 9 parts of mulberry leaf, 15 parts of black plum.

[0015] Furthermore, the weight parts of each raw material drug are:

[0016] 12 parts of vinegar bupleurum, 12 parts of stir-fried white peony root, 10 parts of stir-fried fructus aurantii, 11 parts of red peony root, 24 parts of raw rehmannia root, 10 parts of stir-fried peach kernel, 12 parts of angelica root, 11 parts of whole trichosanthes root, 5 parts of liquorice, 10 parts of chuanxiong, 12 parts of dalbergia odorifera, 13 parts of madder, 12 parts of prepared rehmannia root, 12 parts of tuckahoe, 12 parts of cyperus rotundus, 12 parts of curcuma, 16 parts of cassia seed, 13 parts of raw hawthorn, 12 parts of chrysanthemum, 28 parts of raw astragalus, 22 parts of wolfberry, 16 parts of cistanche, 10 parts of polygonatum, 10 parts of cypress seed, 11 parts of prunes, 12 parts of raw coix seed, 8 parts of turtle shell, 10 parts of raw pollen, 16 parts of chicken gizzard lining, 24 parts of raw lily, 12 parts of mulberry leaf, and 16 parts of black plum.

[0017] Furthermore, the weight parts of each raw material drug are:

[0018] 8 parts of vinegar bupleurum, 8 parts of stir-fried white peony root, 8 parts of stir-fried fructus aurantii, 8 parts of red peony root, 18 parts of raw rehmannia root, 8 parts of stir-fried peach kernel, 8 parts of angelica, 9 parts of whole trichosanthes root, 3 parts of liquorice, 8 parts of ligusticum chuanxiong, 8 parts of dalbergia odorifera, 12 parts of madder, 6 parts of prepared rehmannia root, 8 parts of tuckahoe, 8 parts of rhizoma cyrtonemae, 8 parts of curcuma, 12 parts of cassia seed, 12 parts of raw hawthorn, 8 parts of chrysanthemum, 26 parts of raw astragalus, 18 parts of wolfberry, 12 parts of cistanche, 6 parts of polygonatum, 6 parts of cypress seed, 8 parts of prune seed, 8 parts of raw coix seed, 5 parts of turtle shell, 6 parts of raw pollen, 12 parts of chicken gizzard lining, 15 parts of raw lily, 8 parts of mulberry leaf, 12 parts of black plum.

[0019] Furthermore, the weight parts of each raw material drug are:

[0020] 15 parts of vinegar bupleurum, 15 parts of stir-fried white peony root, 10 parts of stir-fried fructus aurantii, 11 parts of red peony root, 25 parts of raw rehmannia root, 10 parts of stir-fried peach kernel, 15 parts of angelica root, 12 parts of whole trichosanthes root, 6 parts of liquorice, 10 parts of chuanxiong, 12 parts of dalbergia odorifera, 18 parts of madder, 15 parts of prepared rehmannia root, 15 parts of tuckahoe, 15 parts of cyperus, 15 parts of curcuma, 18 parts of cassia seed, 18 parts of raw hawthorn, 15 parts of chrysanthemum, 35 parts of raw astragalus, 23 parts of wolfberry, 18 parts of cistanche, 12 parts of polygonatum, 11 parts of cypress seed, 12 parts of prunes, 15 parts of raw coix seed, 8 parts of turtle shell, 10 parts of raw pollen, 18 parts of chicken gizzard lining, 25 parts of raw lily, 15 parts of mulberry leaf, and 18 parts of black plum.

[0021] Furthermore, the raw materials in respective weight portions are mixed to form a paste.

[0022] At the same time, the present invention also provides a paste of a Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, which is special in that:

[0023] The Chinese medicine composition for lowering blood lipids, relieving depression and unblocking meridians is prepared by using the above-mentioned Chinese medicine composition for lowering blood lipids, relieving depression and unblocking meridians.

[0024] At the same time, the present invention also provides a method for preparing the above-mentioned Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, which is special in that it comprises the following steps:

[0025] Step 1, weighing and mixing the raw materials in parts by weight;

[0026] Step 2, add water to the mixed raw materials and boil them for 3 to 5 times, and add water each time to cover the surface of the medicine. Boil for 1 to 2 hours each time, combine the decoctions, filter, and obtain a filtrate;

[0027] Step 3: Concentrate the filtrate to obtain a Chinese medicine composition for reducing lipids, relieving depression and dredging meridians.

[0028] Furthermore, step 3 specifically comprises concentrating the filtrate into a paste, then adding ethyl hydroxybenzoate, the mass of which is 0.05% of the paste product, stirring evenly, and then sealing to obtain a paste of the final Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians.

[0029] Furthermore, step 2 is specifically as follows: the mixed raw materials are decocted with water for 3 times, with the amount of water added each time being sufficient to cover the surface of the medicine, and each decoction is decocted for 1.5 hours, the decoctions are combined, filtered, and a filtrate is obtained.

[0030] Beneficial effects of the present invention:

[0031] 1. The present invention provides a Chinese medicine composition for reducing blood lipids, relieving depression and unblocking meridians. The Chinese medicine composition is guided by the "Xianghuo Qi Ji Theory" proposed by Professor Yang Zhen, a master of traditional Chinese medicine, and is composed of prescriptions and medicines. Among them, mulberry leaves and chrysanthemums have the functions of dispelling wind and clearing heat, clearing the liver and improving eyesight, clearing liver fire, nourishing liver yin, mulberry leaves also have the effect of lowering blood sugar, chrysanthemums can both lower blood pressure and prevent cardiovascular diseases; raw hawthorn can cure all food accumulation, has the functions of digestion and stomach, promoting qi and dispersing blood stasis, removing turbidity and reducing blood lipids; Cassia seed, "Pharmacopoeia" says: "It benefits the five internal organs and removes liver heat". It can clear heat and improve eyesight, moisten the intestines and relieve constipation, and has multiple functions such as regulating lipids and stabilizing spots, resisting platelet aggregation, controlling blood pressure, regulating sugar and lipid metabolism, and protecting the liver; the above four medicines are the main ones, which can dispel liver heat, eliminate accumulation and resolve phlegm, and are the main prescriptions for treating fatty liver. Stir-fried peach kernel, Chinese angelica, Chuanxiong, and red peony root can promote qi and relieve pain, activate blood circulation and remove blood stasis; Chinese angelica and raw rehmannia root can nourish blood and remove blood stasis; Chinese rhizome can remove blood stasis and promote menstruation, and guide blood downward; and dalbergia odorifera can promote qi and relieve pain; all of the above are ministerial drugs, which can promote blood circulation and remove blood stasis, regulate qi and relieve pain, improve cardiovascular and cerebrovascular circulation disorders, dilate blood vessels, and reduce lipids. The monarch and ministerial drugs match well, can promote liver qi, clear liver heat, remove liver stasis, nourish liver blood, and prevent cardiovascular and cerebrovascular diseases caused by fatty liver, so as to achieve the effect of preventing diseases before they occur. Polygonatum, Rehmannia root, Lycium barbarum, Raw Astragalus, and Cistanche deserticola can nourish the liver and kidney, replenish essence and marrow, and replenish qi and yin; Raw lily and cypress seed can nourish yin and clear heat, nourish the heart and calm the mind; Curcuma can clear the heart and relieve depression, promote qi and remove blood stasis, promote bile and reduce jaundice, protect the liver, and promote bile secretion and excretion; Poria and raw coix seed can invigorate the spleen and remove dampness; Raw pollen can cool blood and stop bleeding, promote blood circulation and remove blood stasis; Whole trichosanthes can clear heat and remove phlegm, relieve chest congestion, and Rubia cordifolia can cool blood, stop bleeding, and remove Blood stasis, menstruation, promote blood coagulation, increase white blood cells; Prunus mume combined with Cistanche deserticola, Platycladus orientalis, stir-fried peach kernel, and whole Trichosanthes kirilowii can enhance the function of moistening the intestines and relieving constipation; Chicken gizzard lining can digest food and resolve accumulation, astringe sperm and stop nocturnal emission, promote gastric motility, enhance the activity of pepsin and pancreatic lipase; Beast shell nourishes yin and suppresses yang, softens and disperses nodules, reduces fever and eliminates steaming, can enhance immunity and prevent cell mutation; Plum astringes the lungs, astringes the intestines, promotes fluid production, and calms ascaris. The above are adjuvants, and combined use can replenish qi and nourish yin, regulate liver and kidney, moisten the intestines and relieve constipation, with the characteristics of warming but not dryness, and replenishing but not stagnating, can regulate qi, blood, yin and yang, and has a tonic effect for the elderly, weak or sickly. Vinegar Bupleurum, stir-fried white peony root, stir-fried Citrus aurantium, and licorice are the guiding drugs, and the combination of the four drugs can soothe the liver and spleen, relieve depression and penetrate heat, and can disperse the heat evil of the yin meridians. The drug carrier is applied to the four extremities and the whole body with yang qi, so that the qi mechanism is adjusted and yin and yang are restored. The whole formula has the effects of clearing the liver and lowering fat, removing blood stasis and unblocking meridians, regulating qi and relieving depression. No obvious adverse reactions have been observed clinically and the therapeutic effect is remarkable.

[0032] 2. Compared with traditional decoctions, the paste of Chinese medicine composition has the advantages of mild efficacy, long-lasting effect, avoidance of decoction, suitable taste, and easy carrying, which greatly improves the patient's compliance with treatment.

[0033] 3. The present invention can clear the liver and reduce fat, dissipate blood stasis and dredge meridians, regulate qi and relieve depression, and has a good preventive and therapeutic effect on metabolic-related diseases such as obesity, fatty liver, diabetes, and cardiovascular and cerebrovascular diseases. It also has a positive conditioning effect on sub-healthy people with glucose and lipid metabolism disorders, fully embodying the Chinese medicine idea of ​​"preventing before illness" and "preventing changes after illness". In addition, the present invention does not add flavoring agents, and all are concentrates extracted from natural Chinese medicinal materials, which can give full play to the original efficacy of the present invention to a greater extent.

[0034] 4. The present invention provides a method for preparing a Chinese medicine composition for lowering blood lipids, relieving depression and unblocking meridians. Since the raw materials contain sour medicines such as black plum and raw hawthorn, and sweet medicines such as licorice, raw rehmannia, cooked rehmannia, and wolfberry, the original medicinal flavor can be decocted by adding water: slightly fragrant, sour, slightly bitter and sweet. DETAILED DESCRIPTION

[0035] Embodiment 1

[0036] A Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, comprising 90g of vinegar bupleurum, 90g of stir-fried white peony root, 90g of stir-fried fructus aurantii, 90g of red peony root, 200g of raw rehmannia root, 90g of stir-fried peach kernel, 90g of angelica root, 100g of whole trichosanthes root, 40g of liquorice, 90g of chuanxiong, 90g of dalbergia odorifera, 150g of madder root, 80g of prepared rehmannia root, 90g of tuckahoe, 90g of cyperus rotundus, 90g of gold, 150g of cassia seed, 150g of raw hawthorn, 90g of chrysanthemum, 300g of raw astragalus, 200g of wolfberry, 150g of Cistanche deserticola, 80g of polygonatum, 90g of cypress seed, 100g of Prunus mume seed, 90g of raw coix seed, 60g of turtle shell, 90g of raw pollen, 150g of chicken gizzard lining, 200g of raw lily, 90g of mulberry leaf, and 150g of black plum.

[0037] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0038] Step 1, weigh 90g of vinegar bupleurum, 90g of stir-fried white peony root, 90g of stir-fried fructus aurantii, 90g of red peony root, 200g of raw rehmannia root, 90g of stir-fried peach kernel, 90g of angelica, 100g of whole trichosanthes root, 40g of licorice, 90g of chuanxiong, 90g of dalbergia odorifera, 150g of madder, 80g of prepared rehmannia root, 90g of tuckahoe, 90g of cyperus, 90g of curcuma, 150g of cassia seed, 150g of raw hawthorn, 90g of chrysanthemum, 300g of raw astragalus, 200g of wolfberry, 150g of cistanche, 80g of polygonatum, 90g of cypress seed, 100g of prunes, 90g of raw coix seed, 60g of turtle shell, 90g of raw pollen, 150g of chicken gizzard lining, 200g of raw lily, 90g of mulberry leaf, and 150g of ebony, and mix;

[0039] Step 2, add water to the raw materials mixed in step 1 and boil them for 3 times, with the amount of water added each time being appropriate to cover the surface of the medicine, boil for 1.5 hours each time, combine the decoctions, filter, and obtain a filtrate;

[0040] Step 3, concentrating the filtrate obtained in step 2 to a paste, then adding ethyl hydroxybenzoate, the mass of ethyl hydroxybenzoate being 0.05% of the paste product, stirring evenly, and then sealing to obtain the final paste of the Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians; putting the paste into a sealed container, putting it in a refrigerator, and setting it aside.

[0041] Embodiment 2

[0042] A traditional Chinese medicine composition for lowering blood lipids, relieving depression and dredgeing meridians, comprising 80g of vinegar bupleurum, 80g of stir-fried white peony root, 80g of stir-fried fructus aurantii, 80g of red peony root, 180g of raw rehmannia root, 80g of stir-fried peach kernel, 80g of angelica root, 90g of whole trichosanthes root, 30g of liquorice, 80g of chuanxiong, 80g of dalbergia odorifera, 120g of madder root, 60g of prepared rehmannia root, 80g of tuckahoe, 80g of radix curcumae, 120g of cassia seed, 120g of raw hawthorn, 80g of chrysanthemum, 260g of raw astragalus, 180g of wolfberry, 120g of cistanche deserticola, 60g of polygonatum, 60g of cypress seed, 80g of prune seed, 80g of raw coix seed, 50g of turtle shell, 60g of raw pollen, 120g of chicken gizzard lining, 150g of raw lily, 80g of mulberry leaf and 120g of black plum.

[0043] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0044] Step 1, weigh 80g of vinegar bupleurum, 80g of stir-fried white peony root, 80g of stir-fried fructus aurantii, 80g of red peony root, 180g of raw rehmannia root, 80g of stir-fried peach kernel, 80g of angelica, 90g of whole trichosanthes root, 30g of licorice, 80g of chuanxiong, 80g of dalbergia odorifera, 120g of madder, 60g of prepared rehmannia root, 80g of tuckahoe, 80g of radix cyrtonemae, 80g of curcuma, 120g of cassia seed, 120g of raw hawthorn, 80g of chrysanthemum, 260g of raw astragalus, 180g of wolfberry, 120g of cistanche, 60g of polygonatum, 60g of cypress seed, 80g of prunes, 80g of raw coix seed, 50g of turtle shell, 60g of raw pollen, 120g of chicken gizzard lining, 150g of raw lily, 80g of mulberry leaf, and 120g of ebony, and mix;

[0045] Step 2, add water to the raw materials mixed in step 1 and decoct them 4 times, with the amount of water added each time being preferably enough to cover the surface of the medicine, decoct for 1 hour each time, combine the decoctions, filter, and obtain a filtrate;

[0046] Step 3, concentrating the filtrate obtained in step 2 to a paste, then adding ethyl hydroxybenzoate, the mass of ethyl hydroxybenzoate being 0.05% of the paste product, stirring evenly, and then sealing to obtain the final paste of the Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians; putting the paste into a sealed container, putting it in a refrigerator, and setting it aside.

[0047] Embodiment 3

[0048] A Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, comprising 150g of vinegar bupleurum, 150g of stir-fried white peony root, 100g of stir-fried fructus aurantii, 110g of red peony root, 250g of raw rehmannia root, 100g of stir-fried peach kernel, 150g of angelica root, 120g of whole trichosanthes root, 60g of liquorice root, 100g of chuanxiong, 120g of dalbergia odorifera, 180g of madder root, 150g of cooked rehmannia root, 150g of tuckahoe, and 150g of cyathula , 150g of Curcuma, 180g of Cassia seed, 180g of raw hawthorn, 150g of chrysanthemum, 350g of raw Astragalus, 230g of wolfberry, 180g of Cistanche, 120g of Polygonatum, 110g of Torreya grandis seed, 120g of Prunus mume seed, 150g of raw Coix seed, 80g of turtle shell, 100g of raw Pollen, 180g of chicken gizzard lining, 250g of raw lily, 150g of mulberry leaf, and 180g of black plum.

[0049] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0050] Step 1, weigh 150g of vinegar bupleurum, 150g of stir-fried white peony root, 100g of stir-fried fructus aurantii, 110g of red peony root, 250g of raw rehmannia root, 100g of stir-fried peach kernel, 150g of angelica root, 120g of whole trichosanthes root, 60g of liquorice, 100g of chuanxiong, 120g of dalbergia odorifera, 180g of madder root, 150g of prepared rehmannia root, 150g of tuckahoe, 150g of cyperus rotundus, 150g of curcuma, 150g of decocted rhizome, 100g of scutellaria baicalensis ... Mix 180g of melaleuca, 180g of raw hawthorn, 150g of chrysanthemum, 350g of raw astragalus, 230g of wolfberry, 180g of Cistanche deserticola, 120g of polygonatum, 110g of cypress seed, 120g of Prunus mume seed, 150g of raw coix seed, 80g of turtle shell, 100g of raw pollen, 180g of chicken gizzard lining, 250g of raw lily, 150g of mulberry leaf, and 180g of ebony;

[0051] Step 2, add water to the raw materials mixed in step 1 and boil them for 5 times, with the amount of water added each time being preferably enough to cover the surface of the medicine, boil them for 2 hours each time, combine the decoctions, filter and obtain the filtrate;

[0052] Step 3, concentrating the filtrate obtained in step 2 to a paste, then adding ethyl hydroxybenzoate, the mass of ethyl hydroxybenzoate being 0.05% of the paste product, stirring evenly, and then sealing to obtain the final paste of the Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians; putting the paste into a sealed container, putting it in a refrigerator, and setting it aside.

[0053] Embodiment 4

[0054] A Chinese medicine composition for reducing lipids, relieving depression and unblocking meridians, comprising 120g of vinegar bupleurum, 120g of stir-fried white peony root, 100g of stir-fried fructus aurantii, 110g of red peony root, 240g of raw rehmannia root, 100g of stir-fried peach kernel, 120g of angelica root, 110g of whole trichosanthes root, 50g of liquorice root, 100g of chuanxiong, 120g of dalbergia odorifera, 130g of madder root, 120g of cooked rehmannia root, 120g of tuckahoe, and 120g of cyathula , turmeric 120g, cassia seed 160g, raw hawthorn 130g, chrysanthemum 120g, raw astragalus 280g, wolfberry 220g, Cistanche 160g, Polygonatum 100g, pine nuts 100g, Prunus mume seeds 110g, raw coix seeds 120g, turtle shell 80g, raw pollen 100g, chicken gizzard 160g, raw lily 240g, mulberry leaves 120g, and black plum 160g.

[0055] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0056] Step 1, weigh 120g of vinegar bupleurum, 120g of stir-fried white peony root, 100g of stir-fried fructus aurantii, 110g of red peony root, 240g of raw rehmannia root, 100g of stir-fried peach kernel, 120g of angelica, 110g of whole trichosanthes root, 50g of liquorice, 100g of chuanxiong, 120g of dalbergia odorifera, 130g of madder, 120g of prepared rehmannia root, 120g of tuckahoe, 120g of cyperus, 120g of curcuma, 120g of decocted rhizome, 100g of tangerine peel ... Mix 160g of melaleuca, 130g of raw hawthorn, 120g of chrysanthemum, 280g of raw astragalus, 220g of wolfberry, 160g of Cistanche deserticola, 100g of polygonatum, 100g of cypress seed, 110g of Prunus mume seed, 120g of raw coix seed, 80g of turtle shell, 100g of raw pollen, 160g of chicken gizzard lining, 240g of raw lily, 120g of mulberry leaf, and 160g of ebony;

[0057] Step 2, add water to the raw materials mixed in step 1 and boil them for 5 times, with the amount of water added each time being preferably enough to cover the surface of the medicine, boil them for 2 hours each time, combine the decoctions, filter and obtain the filtrate;

[0058] Step 3, concentrating the filtrate obtained in step 2 to a paste, then adding ethyl hydroxybenzoate, the mass of ethyl hydroxybenzoate being 0.05% of the paste product, stirring evenly, and then sealing to obtain the final paste of the Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians; putting the paste into a sealed container, putting it in a refrigerator, and setting it aside.

[0059] Application Example 1

[0060] Wang, male, 52 years old, from the Department of Hepatology, Xi'an Traditional Chinese Medicine Hospital, had discomfort in the right flank, abdominal distension, poor appetite, dark red tongue, thin white fur, tooth marks on the sides, thick purple sublingual veins, and deep, stringy and astringent pulse. He was slightly fat, liked to eat fatty and sweet food, and had no history of drinking. The test sheet showed abnormal liver function, and imaging showed fatty liver (severe). He was diagnosed with non-alcoholic fatty liver disease. He took the paste of the Chinese medicine composition obtained in Example 1 for treatment for 3 months. The specific method of taking was: take 1 time each morning and evening, 10 to 15 g (1 teaspoon) each time, and mix with a small amount of boiled water. The above symptoms of the patient disappeared, liver function was basically normal, and imaging showed fatty liver (moderate).

[0061] Application Example 2

[0062] Patient Xiang, male, 35 years old, from the Department of Hepatology, Xi'an Traditional Chinese Medicine Hospital, felt discomfort in the right flank, dry eyes, dry mouth, bitter mouth, poor appetite, and yellow urine. Mild abnormal liver function for many years, upper abdominal ultrasound showed fatty liver (moderate), long-term oral enzyme-lowering drugs (silybin capsules), transaminase increased repeatedly after drug withdrawal, and the effect was not good. Take the paste of the Chinese medicine composition obtained in Example 1 for treatment for 2 months, and the specific method of taking is: take 1 time each morning and evening, 10-15g (1 teaspoon) each time, and mix with a small amount of boiled water. The above symptoms of the patient are alleviated, the weight is reduced compared with before, the liver function is basically normal, and imaging shows fatty liver (mild).

[0063] Application Example 3

[0064] Cui, a 55-year-old female patient from the Department of Hepatology, Xi'an Traditional Chinese Medicine Hospital, had a history of chronic hepatitis B for many years, repeated right hypochondriacal pain, abdominal distension, fatigue, mainly in the lower limbs, dry mouth and bitter mouth, sometimes palpitation, poor appetite, normal urination, dry stool, 2-3 days / time, poor night rest, and difficulty falling asleep. Abdominal obesity, dark red tongue, white and greasy fur, and stringy pulse. Abdominal B-ultrasound showed mild fatty liver, and non-invasive detection of liver fiber: E 11.3kPa, CAP 332dB / m. Electrocardiogram suggested sinus bradycardia. The patient had a history of chronic hepatitis B for many years, and the condition was relatively stable, so the treatment of fatty liver was mainly based on the tongue and pulse, and the syndrome was diagnosed as liver meridian stagnation and heat, turbid blood stasis. The paste of the Chinese medicine composition obtained in Example 2 was taken for treatment for 3 months, and the specific method of taking was: take 1 time each morning and evening, 10-15g (1 teaspoon) each time, and mix with a small amount of boiled water. The patient's right flank pain basically disappeared, palpitations did not occur again, and symptoms such as fatigue were significantly alleviated. Non-invasive liver fibrosis testing showed: E 7.9kPa, CAP 278dB / m, and the weight decreased by 8 catties compared to before.

[0065] Application Example 4

[0066] Sun, male, 48 years old, from the Department of Hepatology, Xi'an Traditional Chinese Medicine Hospital, had dull pain in the liver area, epistaxis, dizziness, occasional palpitations, chest tightness, pain and discomfort in the neck and shoulders, good appetite, occasional dry mouth, and normal bowel movements. The tongue was dark red, with thick yellow fur, thick purple sublingual veins, and a stringy and slippery pulse. He had been drinking for more than 20 years and had not quit, with hypertension. Abdominal B-ultrasound: fatty liver (moderate). Liver function: ALT 135U / L↑, AST 87U / L↑, GGT 278U / L↑, TBA 13.20μmol / l↑. After hospitalization for liver protection and enzyme reduction, the symptoms were alleviated compared with before, and the transaminase was still slightly abnormal. He took the paste of the Chinese medicine composition obtained in Example 3 for 3 months. The specific method of taking it was: take it once a day in the morning and evening, 10 to 15g (1 teaspoon) each time, and mix it with a small amount of boiled water, and advise to quit drinking. The patient's dull pain in the liver area has basically disappeared, no nose bleeding has occurred again, blood pressure is relatively stable, there are no symptoms such as dizziness, palpitations, or chest tightness, and liver function is basically normal.

[0067] Application Example 5

[0068] Li, a 65-year-old female patient from the Department of Hepatology at Xi'an Traditional Chinese Medicine Hospital, had abdominal B-ultrasound showing fatty liver, non-invasive detection of liver fibrosis: E10.7kPa, CAP 291dB / m. She was previously diagnosed as "anxiety depression" by an external hospital. She currently has distension and pain in the right hypochondrium, which is significantly aggravated when she is in a bad mood. The tongue is dark red, the fur is thin and white, there is tortuosity under the tongue, and the pulse is stringy and slippery. Adhere to taking the paste of the Chinese medicine composition obtained in Example 3 for 3 months. The specific method of taking is: take 1 time each morning and evening, 10 to 15g (1 teaspoon) each time, mix with a small amount of boiled water, adjust the diet structure, cooperate with aerobic exercise, and then recheck the non-invasive detection of liver fibrosis: E 6.8kPa, CAP 251dB / m, and the symptoms are alleviated, and the mood is significantly stable than before.

[0069] Application Example 6

[0070] Patient Mr. Li, male, 63 years old, from the Department of Hepatology, Xi'an Traditional Chinese Medicine Hospital. He had right flank discomfort, excessive sweating, especially when moving, poor sleep at night, good appetite, frequent urination at night, and normal bowel movements. Height: 180CM, Weight: 92KG, BMI: 28.4kg / m 2 . Postprandial blood glucose reached 15mmol / l. Non-invasive liver fibrosis: CAP: 324dB / m, electrocardiogram: sinus rhythm. Left axis deviation. 1. Sinus bradycardia 2. ST-T changes. Past history of fatty liver, type 2 diabetes, lacunar cerebral infarction, hyperlipidemia, and arteriosclerosis. Comprehensive consideration is metabolic-related fatty liver disease, intermittent exercise and diet control, but cannot be maintained due to work reasons. After taking the paste of the Chinese medicine composition obtained in Example 4 for 3 months, the symptoms were alleviated, and a low-salt, low-fat diabetic diet and appropriate exercise were advised. The patient persisted in taking it for another 3 months, and his weight dropped to 79KG, BMI: 24.4kg / m 2, non-invasive liver fibrosis: CAP: 276dB / m, blood sugar control is good, symptoms basically disappeared. Specific method of taking: take once a day in the morning and evening, each time 10-15g (1 teaspoon), with a small amount of boiled water.

[0071] Application Example 7

[0072] Yang, male, 54 years old, from the Department of Hepatology, Xi'an Traditional Chinese Medicine Hospital. He was found to have elevated blood sugar for 11 years, height: 175CM weight: 78KG. Glycated hemoglobin measurement: 10.50%, glucose: 15.6mmol / L. Diagnosed with type 2 diabetes with poor blood sugar control. Currently, subcutaneous injection of "aspart insulin 30 30iu before breakfast, 26iu before dinner", blood sugar control is poor. He has the habit of drinking and smoking, and has not quit. He has a history of non-alcoholic fatty hepatitis, coronary atherosclerotic heart disease, hypertension stage 2 (extremely high risk), and hyperuricemia. The patient usually feels dry mouth, bitter mouth, palpitations and chest tightness. The patient's blood sugar control was poor, and he had multiple diseases, and the risk of cardiovascular and cerebrovascular disease recurring was high. The patient was advised to improve his lifestyle, quit smoking and drinking, increase aerobic exercise appropriately, and intermittently take the paste of the Chinese medicine composition obtained in Example 4 for more than half a year. The specific method of taking was: take 1 time in the morning and evening on the day of taking, 10-15g (1 teaspoon) each time, and mix with a small amount of boiled water. The patient's blood sugar was gradually controlled at 7.5-9mmol / l on an empty stomach, insulin was gradually reduced, and the weight dropped by 9 pounds compared with the previous time. The symptoms basically disappeared, and the condition was relatively stable.

[0073] Application Example 8

[0074] Wang, a 57-year-old female patient from the Department of Hepatology at Xi'an Traditional Chinese Medicine Hospital, usually felt chest tightness, palpitations, and dizziness. She is currently taking Chinese patent medicine intermittently for treatment, and her symptoms are sometimes mild and sometimes severe. Later, due to right flank discomfort, abdominal distension, and poor appetite, liver function tests showed: AST 82.6U / L, AKP 123.7U / L, GGT 60.9U / L; blood lipids: TG 2.76mmol / L; fasting blood glucose: 7.5mmol / L. Abdominal ultrasound showed fatty liver (moderate), non-invasive liver fibrosis: liver stiffness value 36.3kPa, CAP264dB / m. The tongue is dark, the tongue coating is white and greasy, there is tortuosity under the tongue, and the pulse is stringy and sluggish. It was diagnosed as fatty liver hyperlipidemia and impaired fasting blood glucose. The patient is a sub-healthy group with disordered glucose and lipid metabolism. Health education is given, and a low-salt, low-fat, low-sugar diet is advised, appropriate exercise is performed, and the patient's symptoms such as right flank discomfort, abdominal distension, and poor appetite are significantly alleviated after taking the paste of the Chinese medicine composition obtained in Example 4 for 1 month, and chest tightness and palpitations are improved. After taking it for 3 months, right flank discomfort and abdominal distension basically disappeared, appetite was good, there were no obvious symptoms such as palpitations and chest tightness, and dizziness was better than before. The specific method of taking is: take it once in the morning and evening, 10 to 15g (1 teaspoon) each time, and mix it with a small amount of boiled water. Liver function shows: AST 45U / L, AKP 68U / L, GGT 61U / L, blood lipids: TG 1.50mmol / L; fasting blood sugar: 6.1mmol / L. Abdominal ultrasound suggests fatty liver (mild), non-invasive liver fibrosis: liver stiffness value 12.1kPa, CAP 215dB / m.

Claims

1. A Chinese medicine composition for reducing lipids, relieving depression and dredging meridians, characterized in that: The raw materials include the following parts by weight: 8-15 parts of vinegar bupleurum, 8-15 parts of stir-fried white peony root, 8-10 parts of stir-fried fructus aurantii, 8-11 parts of red peony root, 18-25 parts of raw rehmannia root, 8-10 parts of stir-fried peach kernel, 8-15 parts of angelica root, 9-12 parts of whole trichosanthes root, 3-6 parts of licorice root, 8-10 parts of chuanxiong, 8-12 parts of dalbergia odorifera, 12-18 parts of madder root, 6-15 parts of cooked rehmannia root, 8-15 parts of tuckahoe, 8-15 parts of cyperus rotundus, 8-15 parts of turmeric, 1 part of cassia seed 2-18 parts, raw hawthorn 12-18 parts, chrysanthemum 8-15 parts, raw astragalus 26-35 parts, wolfberry 18-23 parts, Cistanche 12-18 parts, polygonatum 6-12 parts, pine nuts 6-11 parts, Prunus mume seeds 8-12 parts, raw coix seeds 8-15 parts, turtle shell 5-8 parts, raw pollen 6-10 parts, chicken gizzard 12-18 parts, raw lily 15-25 parts, mulberry leaves 8-15 parts, black plum 12-18 parts.

2. The Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 1, characterized in that: The weight parts of each raw material are: 8-12 parts of vinegar bupleurum, 8-12 parts of stir-fried white peony root, 8-10 parts of stir-fried fructus aurantii, 8-11 parts of red peony root, 18-24 parts of raw rehmannia root, 8-10 parts of stir-fried peach kernel, 8-12 parts of angelica root, 9-11 parts of whole trichosanthes root, 3-5 parts of licorice root, 8-10 parts of chuanxiong, 8-12 parts of dalbergia odorifera, 12-15 parts of madder root, 6-12 parts of cooked rehmannia root, 8-12 parts of tuckahoe, 8-12 parts of cyperus rotundus, 8-12 parts of turmeric, 1 part of cassia seed 2-16 parts, raw hawthorn 12-15 parts, chrysanthemum 8-12 parts, raw astragalus 28-35 parts, wolfberry 18-22 parts, Cistanche 12-16 parts, polygonatum 6-10 parts, pine nuts 6-10 parts, Prunus mume seeds 8-11 parts, raw coix seeds 8-12 parts, turtle shell 5-8 parts, raw pollen 6-10 parts, chicken gizzard 12-16 parts, raw lily 15-24 parts, mulberry leaves 8-12 parts, black plum 12-16 parts.

3. The Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 2, characterized in that: The weight parts of each raw material are: 9 parts of vinegar bupleurum, 9 parts of stir-fried white peony root, 9 parts of stir-fried fructus aurantii, 9 parts of red peony root, 20 parts of raw rehmannia root, 9 parts of stir-fried peach kernel, 9 parts of angelica, 10 parts of whole trichosanthes root, 4 parts of liquorice, 9 parts of ligusticum chuanxiong, 9 parts of dalbergia odorifera, 15 parts of madder, 8 parts of prepared rehmannia root, 9 parts of tuckahoe, 9 parts of rhizoma cyrtonemae, 9 parts of curcuma, 15 parts of cassia seed, 15 parts of raw hawthorn, 9 parts of chrysanthemum, 30 parts of raw astragalus, 20 parts of wolfberry, 15 parts of cistanche, 8 parts of polygonatum, 9 parts of cypress seed, 10 parts of prunes, 9 parts of raw coix seed, 6 parts of turtle shell, 9 parts of raw pollen, 15 parts of chicken gizzard lining, 20 parts of raw lily, 9 parts of mulberry leaf, 15 parts of black plum.

4. The Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 2, characterized in that: The weight parts of each raw material are: 12 parts of vinegar bupleurum, 12 parts of stir-fried white peony root, 10 parts of stir-fried fructus aurantii, 11 parts of red peony root, 24 parts of raw rehmannia root, 10 parts of stir-fried peach kernel, 12 parts of angelica root, 11 parts of whole trichosanthes root, 5 parts of liquorice, 10 parts of chuanxiong, 12 parts of dalbergia odorifera, 13 parts of madder, 12 parts of prepared rehmannia root, 12 parts of tuckahoe, 12 parts of cyperus rotundus, 12 parts of curcuma, 16 parts of cassia seed, 13 parts of raw hawthorn, 12 parts of chrysanthemum, 28 parts of raw astragalus, 22 parts of wolfberry, 16 parts of cistanche, 10 parts of polygonatum, 10 parts of cypress seed, 11 parts of prunes, 12 parts of raw coix seed, 8 parts of turtle shell, 10 parts of raw pollen, 16 parts of chicken gizzard lining, 24 parts of raw lily, 12 parts of mulberry leaf, and 16 parts of black plum.

5. The Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 1, characterized in that: The weight parts of each raw material are: 8 parts of vinegar bupleurum, 8 parts of stir-fried white peony root, 8 parts of stir-fried fructus aurantii, 8 parts of red peony root, 18 parts of raw rehmannia root, 8 parts of stir-fried peach kernel, 8 parts of angelica, 9 parts of whole trichosanthes root, 3 parts of liquorice, 8 parts of ligusticum chuanxiong, 8 parts of dalbergia odorifera, 12 parts of madder, 6 parts of prepared rehmannia root, 8 parts of tuckahoe, 8 parts of rhizoma cyrtonemae, 8 parts of curcuma, 12 parts of cassia seed, 12 parts of raw hawthorn, 8 parts of chrysanthemum, 26 parts of raw astragalus, 18 parts of wolfberry, 12 parts of cistanche, 6 parts of polygonatum, 6 parts of cypress seed, 8 parts of prune seed, 8 parts of raw coix seed, 5 parts of turtle shell, 6 parts of raw pollen, 12 parts of chicken gizzard lining, 15 parts of raw lily, 8 parts of mulberry leaf, 12 parts of black plum.

6. The Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 1, characterized in that: The weight parts of each raw material are: 15 parts of vinegar bupleurum, 15 parts of stir-fried white peony root, 10 parts of stir-fried fructus aurantii, 11 parts of red peony root, 25 parts of raw rehmannia root, 10 parts of stir-fried peach kernel, 15 parts of angelica root, 12 parts of whole trichosanthes root, 6 parts of liquorice, 10 parts of chuanxiong, 12 parts of dalbergia odorifera, 18 parts of madder, 15 parts of prepared rehmannia root, 15 parts of tuckahoe, 15 parts of cyperus, 15 parts of curcuma, 18 parts of cassia seed, 18 parts of raw hawthorn, 15 parts of chrysanthemum, 35 parts of raw astragalus, 23 parts of wolfberry, 18 parts of cistanche, 12 parts of polygonatum, 11 parts of cypress seed, 12 parts of prunes, 15 parts of raw coix seed, 8 parts of turtle shell, 10 parts of raw pollen, 18 parts of chicken gizzard lining, 25 parts of raw lily, 15 parts of mulberry leaf, and 18 parts of black plum.

7. A paste of a Chinese medicine composition for reducing lipids, relieving depression and dredge meridians, characterized in that: The composition is prepared by using the Chinese medicine composition for lowering blood lipids, relieving depression and unblocking meridians as described in any one of claims 1 to 6.

8. A method for preparing the Chinese medicine composition for reducing lipids, relieving depression and dredge meridians as claimed in any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1, weighing and mixing the raw materials in parts by weight; Step 2, add water to the mixed raw materials and boil them for 3 to 5 times, and add water each time to cover the surface of the medicine. Boil for 1 to 2 hours each time, combine the decoctions, filter, and obtain a filtrate; Step 3: Concentrate the filtrate to obtain a Chinese medicine composition for reducing lipids, relieving depression and dredging meridians.

9. The method for preparing the Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 8, characterized in that: Step 3 specifically comprises concentrating the filtrate into a paste, then adding ethyl hydroxybenzoate, the mass of which is 0.05% of the paste product, stirring evenly, and then sealing to obtain the final paste of the Chinese medicine composition for lowering lipids, relieving depression and unblocking meridians.

10. The method for preparing the Chinese medicine composition for reducing lipids, relieving depression and dredge meridians according to claim 9, characterized in that: Step 2 is specifically as follows: the mixed raw materials are decocted with water for 3 times, with the amount of water added each time being sufficient to cover the surface of the medicine, and the decoctions are combined for 1.5 hours each time, and filtered to obtain a filtrate.