Preparation method and application of health food

Abstract

The invention provides a traditional Chinese medicine composition for soothing nerves and promoting intelligence as well as a preparation method and application thereof. The traditional Chinese medicine composition has the effects of improving memory, soothing the nerves and tonifying the brain and comprises the following components in parts by weight: 1-100 parts of poria cocos, 1-100 parts of Chinese yam, 1-50 parts of spina date seeds, 1-50 parts of Chinese wolfberry fruits, 1-50 parts of chrysanthemums, 1-50 parts of rhizoma polygonati, 1-20 parts of longan aril, 0.01-0.1 part of walnut peptides, 0.01-1 part of phosphatidylserine, 0.01-1 part of N-acetylneuraminic acid and 0.1-5 parts of vitamin C. The composition disclosed by the invention has the effects of soothing the nerves, promoting intelligence, nourishing yin and blood, nourishing the heart, tonifying the kidney, tonifying qi, generating blood, improving memory and improving sleep.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, foods and health products, and in particular to a preparation method and application of health food. Background Art

[0002] Memory is an important cognitive function, which includes four processes: recognition, retention, cognition, and recall. Memory loss can affect people's daily work and study at the least, or cause some serious safety accidents at the worst, causing serious damage to others and society. There are many reasons for memory loss, mainly including increased stress, aging, metabolic syndrome, and risk factors. The formation of memory is closely related to the plasticity of neuronal synapses, and one of the main functions of sleep is to restore the plasticity of brain synapses and promote the formation of new memories. Improving sleep quality is closely related to improving memory and brain cognitive ability. Survey results show that the probability of insomnia accompanied by memory loss is as high as 86.81%.

[0003] In recent years, with the continuous acceleration of the pace of life, the nighttime activity time of children and adolescents has increased significantly, the sleep time has decreased significantly, and sleep deprivation has occurred to varying degrees. Sleep deprivation refers to the inability to meet normal sleep due to environmental and personal reasons, which is manifested as reduced sleep or interrupted sleep continuity. Long-term sleep deprivation can easily lead to decreased behavioral ability, inattention, memory loss and decreased learning ability. The phenomenon of insufficient sleep time and insomnia caused by late sleep and procrastination before bedtime in children and adolescents is becoming more and more common. Under heavy academic pressure, the incidence of sleep problems in children and adolescents continues to rise. The "2019 China Youth and Children's Sleep Index White Paper" released by the China Sleep Research Society shows that more than 300 million people in China have sleep disorders, of which about 62.9% of adolescents and children sleep less than 8 hours. Children and adolescents are in a critical period of growth and development. Faced with high-pressure and high-intensity learning, they use their brains more and often feel that their brain capacity is not enough, fatigue or memory loss, lack of concentration, poor sleep, etc. Therefore, improving memory, improving intelligence and brain health, and calming the nerves and nourishing the brain are health care tasks that parents cannot ignore, and are also hot topics of concern in today's society. Insufficient sleep and sleep disorders seem to be potential factors affecting intelligence and learning ability. In this context, the inventors want to provide a composition for improving memory, calming the nerves and nourishing the brain and a preparation method thereof. Summary of the invention

[0004] The present invention aims to provide a Chinese medicine composition having the effects of improving memory, calming nerves and nourishing the brain and a preparation process thereof. The specific technical scheme is as follows:

[0005] First, the present invention provides a Chinese medicine composition, which includes, by weight, 1 to 100 parts of Poria cocos, 1 to 100 parts of Chinese yam, 1 to 50 parts of Chinese date seeds, 1 to 50 parts of Chinese wolfberry, 1 to 50 parts of chrysanthemum, 1 to 50 parts of polygonatum, and 1 to 20 parts of longan pulp. The composition of the present invention can be directly ground into powder, or it can be an extract prepared by conventional means in the art. The Chinese medicine used in the composition of the present invention can also be used in the form of direct grinding into powder, extracts, or other processed forms.

[0006] Preferably, the traditional Chinese medicine composition comprises: 1-50 parts of Poria cocos, 1-50 parts of Chinese yam, 1-30 parts of Ziziphus jujuba seeds, 1-30 parts of wolfberry, 1-30 parts of chrysanthemum, 1-30 parts of Polygonatum sibiricum, and 1-15 parts of longan pulp.

[0007] Preferably, the traditional Chinese medicine composition comprises: 10-30 parts of Poria cocos, 10-30 parts of Chinese yam, 5-20 parts of Ziziphus jujuba seeds, 5-20 parts of wolfberry, 5-20 parts of chrysanthemum, 5-20 parts of Polygonatum sibiricum, and 2-10 parts of longan pulp.

[0008] Preferably, the Chinese medicine composition comprises: 10-20 parts of Poria cocos, 10-20 parts of Chinese yam, 5-15 parts of Ziziphus jujuba seeds, 5-15 parts of wolfberry, 5-15 parts of chrysanthemum, 5-15 parts of Polygonatum sibiricum, and 2-8 parts of longan pulp.

[0009] Preferably, the traditional Chinese medicine composition comprises: 12-18 parts of Poria cocos, 12-18 parts of Chinese yam, 7-13 parts of Ziziphus jujuba seeds, 7-13 parts of wolfberry, 7-13 parts of chrysanthemum, 7-13 parts of Polygonatum sibiricum, and 4-6 parts of longan pulp.

[0010] Preferably, the traditional Chinese medicine composition comprises: 13-17 parts of Poria cocos, 13-17 parts of Chinese yam, 8-12 parts of Ziziphus jujuba seeds, 8-12 parts of wolfberry, 8-12 parts of chrysanthemum, 8-12 parts of Polygonatum sibiricum, and 3-7 parts of longan pulp.

[0011] Preferably, the Chinese medicine composition comprises: 10-15 parts of Poria cocos, 10-15 parts of Chinese yam, 5-10 parts of Ziziphus jujuba seeds, 5-10 parts of wolfberry, 5-10 parts of chrysanthemum, 5-10 parts of Polygonatum sibiricum, and 2-5 parts of longan pulp.

[0012] Most preferably, the Chinese medicine composition comprises: 15 parts of Poria cocos, 15 parts of Chinese yam, 10 parts of Ziziphus jujuba seeds, 10 parts of wolfberry, 10 parts of chrysanthemum, 10 parts of Polygonatum sibiricum, and 5 parts of longan pulp.

[0013] Further, the composition also includes 0.01-0.1 parts of walnut peptide, 0.01-1 parts of phosphatidylserine, 0.01-1 parts of N-acetylneuraminic acid, and 0.1-5 parts of vitamin C. Preferably, 0.01-0.05 parts of walnut peptide, 0.01-0.2 parts of phosphatidylserine, 0.01-0.2 parts of N-acetylneuraminic acid, and 0.1-1.2 parts of vitamin C. Preferably, 0.03-0.05 parts of walnut peptide, 0.2-0.3 parts of phosphatidylserine, 0.2-0.3 parts of N-acetylneuraminic acid, and 1-1.2 parts of vitamin C. Most preferably, 0.05 parts of walnut peptide, 0.2 parts of phosphatidylserine, 0.2 parts of N-acetylneuraminic acid, and 1.2 parts of vitamin C.

[0014] The present invention also proposes the use of the composition in preparing medicines, health products or foods for improving memory, calming nerves and nourishing the brain or improving insomnia.

[0015] The insomnia may be heart-kidney disharmony type insomnia.

[0016] The composition of the present invention can be used for calming the mind and improving intelligence, nourishing yin and blood, nourishing the heart and kidney, replenishing qi and generating blood, improving memory, improving sleep and the like.

[0017] Specifically, the use may be any method that is beneficial to improving the corresponding symptoms of the patient, including treatment or prevention.

[0018] The present invention also provides a medicine, food or health product containing any one of the above-mentioned compositions.

[0019] Specifically, the medicine, food or health product is selected from hard capsules, tablets, granules, soft capsules, oral liquids, compressed candies, gel candies, plant beverages, and solid beverages.

[0020] Furthermore, it also contains the auxiliary materials acceptable in medicine, health products or foods, which are selected from one or more of maltodextrin, corn starch, microcrystalline cellulose, silicon dioxide, magnesium stearate, sorbitol, erythritol, steviol glycosides, sucralose, mogroside, gelatin, xanthan gum, carrageenan, fruit powder and fruit juice.

[0021] Another object of the present invention is to provide a method for preparing the above composition, which specifically comprises the following steps:

[0022] (1) Weighing the raw materials of Poria cocos, Chinese yam, Chinese jujube seed, Chinese wolfberry, chrysanthemum, polygonatum sibiricum, and longan pulp according to the number of portions, removing impurities and washing, adding 5-15 times of water, decocting and extracting 1-3 times, 0.5-3.0 hours per time, obtaining an extract, combining the extracts, and filtering;

[0023] (2) The above extract is concentrated under reduced pressure to an extract with a relative density of 1.10 to 1.15 (55±5°C).

[0024] Another object of the present invention is to provide a method for preparing a pharmaceutical, food or health product granule as follows:

[0025] (1) Weigh the raw materials of Poria cocos, Chinese yam, Chinese jujube seed, Chinese wolfberry, chrysanthemum, polygonatum sibiricum, and longan pulp according to the number of portions, wash them, add 5-15 times of water, decoct and extract 1-3 times, 0.5-3.0 hours per time, obtain an extract, combine the extracts, and filter;

[0026] (2) concentrating the extract under reduced pressure to an extract having a relative density of 1.10 to 1.15 (55±5°C);

[0027] (3) The extract is dried and crushed to obtain dry powder, and walnut peptide, phosphatidylserine, N-acetylneuraminic acid, and vitamin C are added. After fully mixing, excipients acceptable to pharmacy, health products, or food are added to prepare granules.

[0028] In the composition of the present invention, Chinese date seeds and Poria cocos can invigorate the spleen and calm the mind, soothe the soul and nourish the spirit, and gather qi and produce body fluid, and are supplemented with sweet and warm round meat to regulate qi and nourish blood; Chinese yam can benefit kidney yin and consolidate essence, and Polygonatum sibiricum can replenish various deficiencies and fill essence; Lycium barbarum and chrysanthemum can nourish the kidney and produce essence, benefit essence and improve eyesight, clear away heat and remove fire, and all medicines are used together to nourish the heart and kidney, regulate qi and blood, and fill essence and achieve the effect of calming the mind and improving intelligence. This side adopts Chinese herbal medicine with the same origin of medicine and food, which is safe and reliable, can be used for long-term body conditioning, has no toxic side effects, and has no drug dependence, and is safe and effective for long-term consumption. In addition, walnut peptide, phosphatidylserine, N-acetylneuraminic acid, and vitamin C are added to further enhance the efficacy of the composition.

[0029] Experiments show that the composition of the present invention can increase the body weight of rats with insomnia due to heart-kidney disharmony, restore circadian rhythm, make fur smooth and shiny, improve memory, and reduce the levels of CORT, CRH, and ACTH in rat serum. The above also shows that the composition prepared by the present invention has the effects of calming the mind, improving intelligence, nourishing yin and blood, nourishing the heart and kidney, replenishing qi and generating blood, improving memory, and improving sleep.

[0030] The method provided by the invention has mature industrial operation technology, and all raw materials are food grade and can be eaten with confidence; it provides the public with a brand-new composition for improving memory, calming nerves and nourishing the brain, and a preparation method thereof. DETAILED DESCRIPTION

[0031] As mentioned above, the present invention aims to provide a Chinese medicine composition and its preparation method and application. The following will be described in detail in conjunction with the contents of the experimental examples.

[0032] The main raw materials used in the present invention are as follows: Poria cocos: dried sclerotia of the fungus Poria cocos (Schw.) Wolf of the Polyporaceae family; Chinese yam: dried rhizomes of the Dioscorea opposita Thunb. of the Dioscoreaceae family, and Chinese yam slices fried with bran (General Rule 0213) are selected and put into the prescription; Ziziphus jujuba seeds: dried mature seeds of the Ziziphus jujuba Mill. var. spinosa (Bunge) Huex H.F. Chou of the Rhamnaceae family, and Ziziphus jujuba seeds fried with puree (General Rule 0213) are selected and put into the prescription; Lycium barbarum L.: dried mature fruits of the Lycium barbarum L. of the Solanaceae family; Chrysanthemum: dried capitula of the Chrysanthemummorifolium Ramat. of the Asteraceae family; Polygonatum sibiricum: Polygonatum kingianum Coll. et Hemsl., Polygonatum sibiricum Red. or Polygonatum sibiricum Po The dried rhizome of lygonatumcyrtonemaHua, and the polygonatum sibiricum that has been steamed with wine (General Rule 0213) are used in the recipe; longan pulp: the aril of DimocarpuslonganLour., a plant of the Sapindaceae family; walnut peptide powder, this product is made from walnut as the raw material, purchased from Xinghui Tianli (Hangzhou) Pharmaceutical Co., Ltd., and can be made by controlled enzymatic hydrolysis technology, refined separation, purification, drying and packaging; phosphatidylserine, purchased from Shaanxi Baichuan Kangze Biotechnology Co., Ltd., specification 20% (7948-5), can be made from soybean lecithin and L-serine as raw materials, after phospholipase conversion reaction, purification and concentration, and then secondary purification, drying and packaging; N-acetylneuraminic acid: a new food raw material, molecular formula C11H19NO9, molecular weight 309.27, is an amino monosaccharide with a nine-carbon skeleton. If no specific conditions are specified in the present invention, the process is carried out under conventional conditions or conditions recommended by the manufacturer. The raw materials or excipients used, as well as the reagents or instruments used, whose manufacturers are not specified, are all conventional products that can be obtained commercially.

[0033] Example 1 Chinese medicine compound capsule

[0034] Formula: 10 parts of Poria cocos, 30 parts of Chinese yam, 5 parts of Ziziphus jujuba seeds, 5 parts of Chinese wolfberry, 20 parts of chrysanthemum, 20 parts of Polygonatum sibiricum, 10 parts of longan pulp, 0.03 parts of walnut peptide, 0.3 parts of phosphatidylserine, 0.3 parts of N-acetylneuraminic acid, 1.0 parts of vitamin C

[0035] The preparation method of the Chinese medicine composition capsule:

[0036] According to the above medicinal materials, after impurities are removed and washed, 10 times of water is added, and the extract is decocted and extracted twice, 1 hour each time, to obtain an extract, the extract is combined, filtered, and the filtrate is decompressed and concentrated to a fluid extract with a relative density of 1.10-1.15 (55±5°C), and then spray-dried to obtain a fine powder dry extract, walnut peptide, phosphatidylserine, N-acetylneuraminic acid, and vitamin C are added, and mixed evenly to obtain a Chinese medicine composition. A certain auxiliary material is added, and after spraying 90% ethanol to wet the material, it is placed in a swing granulator for wet granulation and dried at 60°C; the dried particles are granulated and divided into capsules to obtain a Chinese medicine compound capsule.

[0037] Example 2 Chinese medicine compound granules

[0038] Prescription: 15 parts of Poria cocos, 15 parts of yam, 10 parts of Ziziphus jujuba seeds, 10 parts of wolfberry, 10 parts of chrysanthemum, 10 parts of Polygonatum sibiricum, 5 parts of longan pulp, 0.05 parts of walnut peptide, 0.2 parts of phosphatidylserine, 0.2 parts of N-acetylneuraminic acid, and 1.2 parts of vitamin C.

[0039] The preparation method of the Chinese medicine composition granules:

[0040] According to the above medicinal materials, after impurities are removed and washed, 10 times of water is added, and the extract is boiled and extracted twice, 1h / time, to obtain an extract, the extract is combined, filtered, and the filtrate is decompressed and concentrated to a fluid extract with a relative density of 1.10-1.15 (55±5°C), and then spray-dried to obtain a fine powder dry extract, walnut peptide, phosphatidylserine, N-acetylneuraminic acid, and vitamin C are added, and mixed uniformly to obtain a Chinese medicine composition. A certain amount of maltodextrin is added, and after spraying 90% ethanol to wet the material, it is placed in a swing granulator for wet granulation, dried at 60°C, and the whole granules are packaged to obtain a Chinese medicine compound granule, which is packaged in aluminum-plastic sealed bags and stored in a cool and dry place.

[0041] Example 3 Effect of the Chinese herbal composition of the invention on body weight, learning and memory ability, and serum CORT, CRH, and ACTH levels in rats with insomnia of heart-kidney disharmony type

[0042] The experiment used SPF-grade SD male mice to construct an animal model. After the model animals were given the Chinese medicine composition by gavage, the Morris water maze test and serum corticosterone (CORT), corticotropin-releasing hormone (CRH), and adrenocorticotropic hormone (ACTH) levels were detected to evaluate the learning and memory ability and sleep state of each group of mice in order to clarify the calming and intellectual effects of the Chinese medicine composition.

[0043] 1 Experimental Materials and Methods

[0044] 1.1 Experimental animals

[0045] SPF male SD rats, with an initial body weight of 200±20g, were bred for 5 days at a temperature of 25±2℃, a relative humidity of 50%-60%, and a 12h light-dark cycle before the experiment. During the experiment, the animals were allowed to drink water and eat freely.

[0046] 1.2 Test drug

[0047] The Chinese medicine composition prepared in Example 2

[0048] 1.2 Experimental modeling, grouping and drug administration

[0049] Rats were randomly divided into normal control group, model group, experimental low-dose group (1.8g crude drug / kg), experimental medium-dose group (3.6g crude drug / kg), and experimental high-dose group (7.2g crude drug / kg), with a total of 5 groups, 10 rats in each group. Rats in the model group and experimental group were subjected to different stimulation conditions for 1-14 days, and 1-2 stimulations were randomly arranged every day, mainly including fasting, water deprivation, swimming in 4℃ ice water, tail clamping, tail shaking, wet bedding for 24 hours, cage tilting 45°, restraint stress, noise stimulation, flash stimulation, horizontal vibration, day and night reversal, etc., to avoid rats from adapting to external stimulation. On the 15th day, rats were intraperitoneally injected with para-chlorophenylalanine (PCPA) suspension, once / d, for 3 consecutive days. The circadian rhythm of rats disappeared, they slept less, were listless, and their hair was dry and easy to fall off, indicating that the rat model of insomnia caused by heart-kidney disharmony was successfully replicated. The rats in the normal group were fed with normal feed and drinking water during the 1st to 14th day without any stimulation. The rats in the normal group were intraperitoneally injected with an equal volume of saline on the 15th to 17th day. After the model was successfully established, the normal control group and the model control group were gavaged with 1 mL / 100 g of distilled water according to body weight, and the experimental groups were gavaged with corresponding drugs at a volume of 1 mL / 100 g body weight, once a day.

[0050] 1.3 Experimental index determination

[0051] 1.3.1 Measurement of rat body weight

[0052] The body weight of each rat was measured before the experiment and on the 7th, 14th, 17th and 24th days of the experiment.

[0053] 1.3.2 Behavioral evaluation of rats

[0054] The behavioral state (jumping, bumping, lying tied up, squinting), activity level (slow, weakened, normal, active), insomnia (looking around, easily frightened, manic, excited), hair and skin (dry and dirty, dull, ordinary, smooth and shiny) and mental state (listless, sleeping, normal, excited) of each group of rats were observed. The observation time of the rats' state was 10:00-12:00 every day.

[0055] 1.3.3 Test of rat learning and memory ability

[0056] On the 19th day of the experiment, rats in each group were subjected to a 4-day orientation navigation test and a 1-day spatial exploration test according to the Morris water maze training experimental operation. In the orientation navigation test, the pool was divided into four quadrants (the upper right, upper left, lower left, and lower right were quadrants one to four, respectively). A platform was placed in the center of the third quadrant, 2.5 cm below the horizontal plane. The midpoint of each quadrant arc was selected as the fixed entry point for rats to test the learning and memory ability of rats in the water maze. In the spatial exploration test, the platform was removed on the 23rd day, and all experimental rats were placed in the water in the first quadrant facing the pool wall. The number of times the rats crossed the original platform position within 120 seconds and the swimming time in the third quadrant were recorded.

[0057] 1.3.4 Detection of CRH, ACTH, and CORT levels in rat serum

[0058] 2 hours after the last administration, the rats were anesthetized by intraperitoneal injection of 10% chloral hydrate, and blood was collected from the abdominal aorta. After standing for 1 hour, the supernatant was collected after centrifugation at 3500 rpm and 4°C for 15 minutes. ELISA was used to detect the levels of CRH, ACTH and CORT in the serum of rats in each group.

[0059] 1.4 Statistical analysis

[0060] SPSS 23.0 software was used for data processing. The two groups were compared using the independent sample t test, and P < 0.05 indicated a statistically significant difference.

[0061] 2. Experimental results

[0062] 2.1 Effect on rat body weight

[0063] As shown in Table 1, after 7 days of different conditional stimulation, the body weight of the model group decreased significantly compared with the normal rats (p < 0.01). After the last administration, the body weight of the rats in the three experimental groups increased significantly compared with the model group (p < 0.05, p < 0.01), and the increase in the experimental medium and high dose groups was higher than that in the low dose group.

[0064] Table 1 Effect of Chinese medicine combination on body weight of rats with insomnia of heart-kidney disharmony type ( n=10)

[0065]

[0066] Note: Compared with the normal group##P<0.01; compared with the model group*P<0.05, **P<0.01

[0067] 2.2 Effects on general behavior of rats

[0068] After the modeling was completed, compared with the normal group, the modeled rats had less sleep time, dry and easy-to-fall hair, listlessness, slow reaction, and pathological manifestations similar to the clinical syndrome of insomnia caused by heart-kidney disharmony in traditional Chinese medicine. After the intervention of the tested Chinese medicine composition, compared with the model group, the rats in the experimental group had significantly less daytime activity, were tired and sleepy, and the circadian rhythm began to recover, and the fur gradually became smooth and shiny.

[0069] 2.3 Effects on learning and memory abilities of rats

[0070] As shown in Table 2, compared with the normal group, the number of times the rats in the model group crossed the original platform was significantly reduced (P<0.01), and the time they stayed in the third quadrant was significantly shortened (P<0.05). Compared with the model group, the number of times the rats in the three experimental groups crossed the original platform and the time they stayed in the third quadrant were significantly increased (P<0.05, P<0.01), and the increase was more significant in the experimental medium and high dose groups.

[0071] Table 2 Effect of Chinese medicine combination on learning and memory ability of rats with insomnia of heart-kidney disharmony type ( n=10)

[0072]

[0073]

[0074] Note: Compared with the normal group, #P<0.05, ##P<0.01; compared with the model group, *P<0.05, **P<0.01.

[0075] 2.4 Effects on CORT, CRH, and ACTH levels in rat serum

[0076] As shown in Table 3, compared with the normal group, the levels of CORT, CRH and ACTH in the serum of the rats in the model group were significantly increased (P<0.01); compared with the model group, the three experimental groups were able to reduce the levels of CORT, CRH and ACTH in the serum of the rats to varying degrees (P<0.05, P<0.01), and the medium and high doses of the Chinese medicine combination had better regulatory effects.

[0077] Table 3 Effect of Chinese herbal medicine combination on serum CORT, CRH and ACTH levels in rats with insomnia of heart-kidney disharmony type ( n=10)

[0078]

[0079] Note: Compared with the normal group, ##P<0.01; compared with the model group, *P<0.05, **P<0.01.

[0080] 3. Experimental Summary

[0081] PCPA is a specific inhibitor of 5-HT biosynthesis in the brain. Intraperitoneal injection of PCPA can cause insomnia in animals and is a commonly used model at home and abroad. The insomnia rat model established by multi-factor co-stimulation can lead to energy metabolism disorders, reduced activity and activation of the hypothalamus-pituitary-adrenal axis (HPA axis) in rats, showing more clinical symptoms consistent with insomnia caused by heart-kidney disharmony in traditional Chinese medicine. This modeling method has a high success rate, good reliability and stability, and is an ideal model for studying the efficacy and mechanism of insomnia drugs.

[0082] Insomnia is closely related to HPA axis dysfunction and neurotransmitter level disorders. The three hormones secreted by the HPA axis: CORT, CRH, and ACTH are all related to sleep regulation. Under stress, the amygdala will be activated, leading to the activation of the HPA axis and increased secretion of CRH. The concentrations of ACTH and CORT will also increase, leading to a wakefulness effect. Studies have found that under insomnia, HPA axis activation can promote the synthesis and secretion of ACTH and CORT, leading to an increase in ACTH and CORT levels compared to normal, thereby increasing the irritability of the cerebral cortex and increasing wakefulness, which is an important link in causing insomnia.

[0083] The research results of the present invention found that after modeling, the circadian rhythm of rats disappeared, the reaction was slow, the hair was dry, and the HPA axis was hyperactive, which was manifested by a significant increase in the levels of CRH, ACTH and CORT. After intervention with the Chinese medicine composition of the present invention, the circadian rhythm of rats was restored, the fur became smooth and shiny, and the levels of various hormones in the serum HPA axis of insomnia rats were significantly downregulated, and the sleep behavior of insomnia rats was improved. The regulating effect of the Chinese medicine composition of medium and high doses was more significant, indicating that the Chinese medicine composition of the present invention can be used to treat insomnia.

[0084] The results of this study show that the tested Chinese herbal composition can also improve the learning and memory abilities of rats with insomnia due to heart-kidney disharmony, reduce the levels of CORT, CRH, and ACTH in serum, and the high-dose Chinese herbal composition has a stronger regulatory effect, thereby achieving the effect of improving sleep. This result verifies that the composition of the present invention has the effects of calming the mind and improving intelligence, and can provide a reference for research on insomnia due to heart-kidney disharmony, learning ability, memory loss, etc.

[0085] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Chinese medicine composition for calming the nerves and improving intelligence, characterized in that: In terms of weight ratio, the Chinese medicine composition comprises: 1-100 parts of Poria cocos, 1-100 parts of Chinese yam, 1-50 parts of Ziziphus jujuba seeds, 1-50 parts of wolfberry fruits, 1-50 parts of chrysanthemum, 1-50 parts of Polygonatum sibiricum, and 1-20 parts of longan pulp.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises: 10-30 parts of Poria cocos, 10-30 parts of Chinese yam, 5-20 parts of Chinese jujube kernels, 5-20 parts of wolfberry, 5-20 parts of chrysanthemum, 5-20 parts of polygonatum, and 2-10 parts of longan pulp.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition comprises: 10-15 parts of Poria cocos, 10-15 parts of yam, 5-10 parts of spinach kernels, 5-10 parts of wolfberries, 5-10 parts of chrysanthemums, 5-10 parts of polygonatum, and 2-5 parts of longan pulp.

4. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises: 15 parts of Poria cocos, 15 parts of Chinese yam, 10 parts of Chinese jujube seeds, 10 parts of wolfberry fruits, 10 parts of chrysanthemum, 10 parts of polygonatum, and 5 parts of longan pulp.

5. The Chinese medicine composition according to claims 1-4, characterized in that: The traditional Chinese medicine composition also includes 0.01-0.1 parts of walnut peptide, 0.01-1 parts of phosphatidylserine, 0.01-1 parts of N-acetylneuraminic acid, and 0.1-5 parts of vitamin C.

6. A medicine, food or health product containing the Chinese medicine composition according to any one of claims 1 to 5.

7. The medicine, food or health product according to claim 6, characterized in that: The auxiliary materials are selected from one or more of maltodextrin, corn starch, microcrystalline cellulose, silicon dioxide, magnesium stearate, white sugar, sorbitol, erythritol, maltitol, steviol glycosides, sucralose, mogroside, gelatin, xanthan gum, alginate, carrageenan, fruit powder and fruit juice.

8. The medicine, food or health product according to claim 6, characterized in that: The medicine, food or health product is selected from hard capsules, tablets, granules, soft capsules, oral liquids, compressed candies, gel candies, plant beverages and solid beverages.

9. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of medicines, foods or health products for calming the nerves, nourishing the brain, improving memory or improving insomnia.

10. A method for preparing the medicine, food or health product according to claim 6, comprising: Weigh 15 parts of Poria cocos, 15 parts of Chinese yam, 10 parts of Ziziphus jujuba seeds, 10 parts of Chinese wolfberry, 10 parts of chrysanthemum, 10 parts of Polygonatum sibiricum and 5 parts of longan pulp, wash them, add 5-15 times of water, decoct and extract for 1-3 times, 0.5-3.0h / time, obtain extract, combine the extracts, filter and concentrate to obtain an extract with a relative density of 1.10-1.15 (55±5℃); dry, crush and sieve the extract to obtain a dry paste powder, add vitamin C, phosphatidylserine, N-acetylneuraminic acid and walnut peptide, mix well and evenly, and then add excipients acceptable in pharmacy, health products or food.

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