Peritoneal dialysis device

Abstract

The present invention discloses a peritoneal dialysis device, which includes a peritoneal dialysis assembly and a peritoneal dialysis tube detachably connected to the peritoneal dialysis assembly; the peritoneal dialysis assembly includes a dialysis solution bag, a drainage bag and a three-way joint. An inlet joint is provided on the dialysis solution bag. The dialysis solution bag is connected to the three-way joint through an infusion tube. The drainage bag is connected to the three-way joint through a drainage tube. The three-way joint is further connected with a connecting tube. A connecting joint is provided at one end of the connecting tube away from the three-way joint. A protective cap is sleeved on the connecting joint. The present invention solves the problems that the existing protective cap is prone to falling off and the peritoneal dialysis tube is prone to blockage.

Description

Technical Field

[0001] The present invention relates to the technical field of dialysis, and particularly to a peritoneal dialysis device. Background Art

[0002] The peritoneal dialysis solution bag is a combination of drugs and medical devices. When the product is used, the connector protective cap needs to be removed first to connect the connecting connector to the peritoneal dialysis tube on the patient's abdomen. Therefore, during the product's shelf life, the sealing between the protective cap and the connecting connector is particularly important. However, the existing connector protective caps for peritoneal dialysis solution storage are prone to falling off. Often, when the drugs have not been used yet, the protective cap of the interface falls off, resulting in the product being unable to be used. At the same time, when connecting to the patient's abdominal affected area, it is also impossible to effectively ensure that the whole body is not infected due to the falling off of the protective cap, which has a certain risk factor.

[0003] In addition, for the existing peritoneal dialysis tubes, they are mainly made of silicone rubber materials. However, silicone rubber materials are prone to adsorb proteins and bacteria in the peritoneal fluid during peritoneal dialysis, resulting in the blockage of dialysis holes and pipelines. Summary of the Invention

[0004] Based on the technical problems existing in the background art, the present invention proposes a peritoneal dialysis device, which solves the problems of easy falling off of the protective cap and easy blockage of the peritoneal dialysis tube.

[0005] The peritoneal dialysis device proposed by the present invention includes a peritoneal dialysis assembly and a peritoneal dialysis tube detachably connected to the peritoneal dialysis assembly; the peritoneal dialysis assembly includes a dialysis solution bag, a drainage bag, and a three-way joint. An inlet connector is provided on the dialysis solution bag. The dialysis solution bag is connected to the three-way joint through an infusion tube. The drainage bag is connected to the three-way joint through a drainage tube. The three-way joint is also connected to a connecting tube. A connecting connector is provided at one end of the connecting tube away from the three-way joint, and a protective cap is sleeved on the connecting connector.

[0006] Preferably, the protective cap includes a sleeve. A clamping groove is formed inside the bottom end of the sleeve. A top block is formed inside the top end of the sleeve by opening an installation groove. Triangularly-shaped pulling blocks are fixedly connected to the outer walls on both sides of the sleeve near the lower end. A pull ring is fixedly connected to the side of the pulling blocks away from the sleeve. One end of the connecting connector is inserted into the clamping groove, and the top block is inserted into the connecting connector.

[0007] Preferably, symmetrically arranged support rods are fixedly connected to the outer side walls on both sides of the sleeve near the bottom end. Vertical plates are fixedly connected to the sides of the support rods away from the sleeve. Elastic telescopic rods are fixedly connected to the opposite sides of the vertical plates near the lower end. Clamping plates are fixedly connected to the output ends of the elastic telescopic rods. Springs are fixedly connected to both the clamping plates and the vertical plates, and the springs are movably sleeved outside the elastic telescopic rods.

[0008] Preferably, soft pads are fixedly connected to the sides of the clamping plates away from the elastic telescopic rods; the clamping plates are integrally arranged in an arc shape at the bottom end of the housing.

[0009] Preferably, a sealing ring is fixedly connected to the inner side wall of the notch of the clamping groove.

[0010] Preferably, the peritoneal dialysis tube includes a tube body. A plurality of dialysis holes are formed at one end of the tube body. The end of the tube body away from the dialysis holes is detachably connected to the connection joint. First rings and second rings are also arranged on the tube body at intervals.

[0011] Preferably, the tube body is made of a cross-linked ethylene-octene copolymer doped with barium sulfate powder, and a protective layer is arranged on the tube wall of the tube body.

[0012] Preferably, the method steps for arranging the protective layer on the tube wall of the tube body are as follows:

[0013] S1: Acidify the tube body, and then add a polyethyleneimine solution for amino modification;

[0014] S2: Immerse the tube body after amino modification in S1 in a first protective liquid, take it out and dry it, and then immerse it in a second protective liquid. Repeat immersing in the first protective liquid and the second protective liquid 3-6 times to form a protective layer on the tube wall of the tube body.

[0015] Preferably, in S1, acidification is carried out with a potassium permanganate-sulfuric acid solution, and the mass fraction of the sulfuric acid solution is 30-60%; the mass concentration of the polyethyleneimine solution is 0.04-0.08%.

[0016] Preferably, in S2, the first protective liquid is a polysaccharide solution with a mass concentration of 10-30 g / L. The polysaccharide is composed of polygonatum polysaccharide, red algae polysaccharide and auricularia auricula polysaccharide in a mass ratio of 2:1-4:1-4. The temperature for each immersion in the first protective liquid is 30-50 °C, and the time is 10-30 min; the second protective liquid is composed of methacryloxypropylcaged polyhedral oligomeric silsesquioxane and polydimethylsiloxane in a mass ratio of 3:1-9. The temperature for each immersion in the second protective liquid is 40-60 °C, and the time is 10-20 min.

[0017] The beneficial technical effects of the present invention:

[0018] (1) In the present invention, by changing the top of the cap body from a flat surface to a groove, the inner part of the cap body fits closely with the circular surface at the top of the joint. The circular shape of the annular edge of the cap body fits more closely with the outer surface of the joint, becoming a resistance to the opening of the protective cap. The annular surface is changed to a symmetrically hollowed arc on both sides, making the force application point for opening the pull ring concentrated and facilitating opening. The two wings of the cap body are injection-molded into triangles and connected to the pull ring part, buffering the pull ring force and being not easily broken. At the same time, in cooperation with the telescopic rod and the spring, it is convenient to drive the clamping plate to connect to the lower pipeline in the afternoon, further increasing the overall connection stability and being not easily detached.

[0019] (2) In the present invention, by forming a protective layer on the peritoneal dialysis tube, the precipitation of barium sulfate powder and cross-linking agent can be effectively avoided, thereby reducing the risk of peritonitis in dialysis patients. Moreover, the protective layer can also prevent the attachment of protein and bacteria in the peritoneal fluid to the tube wall, resulting in the blockage of dialysis holes and the tube body. Among them, the polysaccharide in the first protective liquid can form a chemical bond with the amino-modified tube wall and penetrate into the second protective liquid through the method of layer-by-layer self-assembly. Under the action of the cross-linking agent in the tube body itself, a cross-linked network structure can be formed, which not only improves the smoothness of the tube wall surface but also has excellent anticoagulant effects, and at the same time can avoid the precipitation of barium sulfate powder and cross-linking agent in the tube body. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is a schematic structural diagram of the peritoneal dialysis assembly proposed by the present invention;

[0021] Figure 2 is a schematic structural diagram of the protective cap proposed by the present invention;

[0022] Figure 3 is a side view of the protective cap proposed by the present invention;

[0023] Figure 4 is a top view of the protective cap proposed by the present invention;

[0024] Figure 5 is a side sectional view of the protective cap proposed by the present invention;

[0025] Figure 6 is a bottom view of the protective cap proposed by the present invention;

[0026] Figure 7 is a schematic structural diagram of the peritoneal dialysis tube proposed by the present invention.

[0027] In the figure: 1 - dialysis solution bag, 2 - liquid inlet joint, 3 - infusion tube, 4 - drainage bag, 5 - drainage tube, 6 - three-way joint, 7 - connection joint, 8 - protective cap, 81 - sleeve, 82 - card slot, 83 - top block, 84 - pull block, 85 - pull ring, 86 - support rod, 87 - vertical plate, 88 - elastic telescopic rod, 89 - clamping plate, 810 - spring, 811 - sealing ring, 812 - soft pad, 9 - connecting tube, 10 - tube body, 11 - first sleeve ring, 12 - second sleeve ring, 13 - dialysis hole. Detailed implementation manner

[0028] The present invention will be further explained below in conjunction with specific embodiments.

[0029] Embodiment 1

[0030] Referring to Figures 1-6 , the peritoneal dialysis device proposed by the present invention includes a peritoneal dialysis assembly and a peritoneal dialysis tube detachably connected to the peritoneal dialysis assembly; the peritoneal dialysis assembly includes a dialysis solution bag 1, a drainage bag 4 and a three-way joint 6. An inlet joint 2 is provided on the dialysis solution bag 1. The dialysis solution bag 1 is connected to the three-way joint 6 through an infusion tube 3. The drainage bag 4 is connected to the three-way joint 6 through a drainage tube 5. The three-way joint 6 is also connected to a connecting tube 9. A connection joint 7 is provided at one end of the connecting tube 9 away from the three-way joint 6. A protective cap 8 is sleeved on the connection joint 7.

[0031] The protective cap 8 includes a sleeve 81. A card slot 82 is opened inside the bottom end of the sleeve 81. A top block 83 is formed inside the top end of the sleeve 81 by opening an installation slot. On both outer walls of the sleeve 81 near the lower end position, triangularly arranged pull blocks 84 are fixedly connected. A pull ring 85 is fixedly connected to the common side of the pull blocks 84 away from the sleeve 81. One end of the connection joint 7 is inserted into the card slot 82, and the top block 83 is inserted into the connection joint 7.

[0032] On both outer side walls of the sleeve 81 near the bottom end position, symmetrically arranged support rods 86 are fixedly connected. On the side of the support rods 86 away from the sleeve 81, vertical plates 87 are fixedly connected. On the opposite sides of the vertical plates 87 near the lower end position, elastic telescopic rods 88 are fixedly connected. Clamping plates 89 are fixedly connected to the output ends of the elastic telescopic rods 88. Springs 810 are fixedly connected to both the clamping plates 89 and the vertical plates 87. The springs 810 are movably sleeved outside the elastic telescopic rods 88.

[0033] Soft pads 812 are fixedly connected to the sides of the clamping plates 89 away from the elastic telescopic rods 88; the clamping plates 89 are integrally arranged in an arc shape at the bottom end of the sleeve 81.

[0034] A sealing ring 811 is fixedly connected to the inner side wall of the card slot 82 at the slot opening.

[0035] Referring to Figure 7, the peritoneal dialysis tube includes a tube body 10. One end of the tube body 10 is provided with a plurality of dialysis holes 13. The end of the tube body 10 far from the dialysis holes 13 is detachably connected to a connection joint 7. The tube body 10 is also provided with a first collar 11 and a second collar 12 which are distributed at intervals.

[0036] In the present invention, the inner card slot 82 of the housing 81 is stably sleeved on the connection joint. At the same time, the top block 83 formed in the inner part of the top of the housing 81 by the arranged installation groove makes the inner part of the cap body fit tightly with the circular surface at the top of the joint. Moreover, the circular edge of the cap body of the whole housing 81 fits more closely to the outer surface of the joint, becoming the resistance to the opening of the protective cap. The circular surface is changed to a two-sided symmetrically hollowed arc shape, so that the pulling force application point of the pull ring is concentrated and it is convenient to open. Moreover, the triangularly arranged pull blocks 84 and the pull ring 85 on both sides of the housing 81 greatly increase the connection stability, buffer the pull ring force, are not easy to break, and increase the overall connection stability. At the same time, when the housing 81 is stably connected, the clamping plates 89 are pulled to both sides. The force-applied movement of the clamping plates 89 will compress the spring 810 and the elastic telescopic rod 88. At this time, with the elastic action of the spring 810 and the elastic telescopic rod 88, the clamping plates 89 will be stably driven to clamp on the connection joint to further limit the position, thereby further increasing the connection stability between the housing 81 and the connection joint 7. When in use, the housing 81 is pulled open through the pull ring 85 and the pull block 84, and then the connection joint 7 is connected to the tube body 10 of the peritoneal dialysis tube inserted into the patient's abdominal cavity.

[0037] In order to solve the precipitation of barium sulfate powder and cross-linking agent in the tube body, thereby reducing the risk of peritonitis in dialysis patients, and the protective layer can also avoid the problems of blockage of the dialysis holes and the tube body caused by the attachment of protein and bacteria in the peritoneal fluid to the tube wall. The tube body 10 is made of cross-linked ethylene-octene copolymer doped with barium sulfate powder, and a protective layer is provided on the tube wall of the tube body. The method steps for providing a protective layer on the tube wall of the tube body are as follows:

[0038] S1: Acidify the tube body, and then add a polyethyleneimine solution for amino modification;

[0039] S2: Immerse the tube body after amino modification in S1 in the first protective liquid, take it out and dry it, and then immerse it in the second protective liquid. Repeat the immersion in the first protective liquid and the second protective liquid 4 times to form a protective layer on the tube wall of the tube body.

[0040] In S1, acidification is carried out with a potassium permanganate-concentrated sulfuric acid solution, and the mass fraction of the concentrated sulfuric acid solution is 45%; the mass concentration of the polyethyleneimine solution is 0.06%.

[0041] In S2, the first protective liquid is a polysaccharide solution with a mass concentration of 20 g / L. The polysaccharide is composed of polygonatum polysaccharide, rhodophyta polysaccharide and auricularia auricula polysaccharide in a mass ratio of 1:1:1. The temperature for each immersion in the first protective liquid is 40 °C and the time is 20 min. The second protective liquid is composed of methacryloxypropylcaged polyhedral oligomeric silsesquioxane and polydimethylsiloxane in a mass ratio of 1:1. The temperature for each immersion in the second protective liquid is 50 °C and the time is 15 min.

[0042] Example 2

[0043] The method steps for setting a protective layer on the tube wall of the peritoneal dialysis tube body proposed by the present invention are as follows:

[0044] S1: Acidify the tube body and then add a polyethyleneimine solution for amination modification;

[0045] S2: Immerse the amination-modified tube body in S1 into the first protective liquid, take it out and dry it, then immerse it in the second protective liquid. Repeat the immersion in the first protective liquid and the second protective liquid 3 times to form a protective layer on the tube wall of the tube body.

[0046] In S1, acidification is carried out with a potassium permanganate - concentrated sulfuric acid solution, and the mass fraction of the concentrated sulfuric acid solution is 30%; the mass concentration of the polyethyleneimine solution is 0.04%.

[0047] In S2, the first protective liquid is a polysaccharide solution with a mass concentration of 10 g / L. The polysaccharide is composed of polygonatum polysaccharide, rhodophyta polysaccharide and auricularia auricula polysaccharide in a mass ratio of 2:1:1. The temperature for each immersion in the first protective liquid is 30 °C and the time is 10 min. The second protective liquid is composed of methacryloxypropylcaged polyhedral oligomeric silsesquioxane and polydimethylsiloxane in a mass ratio of 3:1. The temperature for each immersion in the second protective liquid is 40 °C and the time is 10 min.

[0048] All other conditions are the same as in Example 1.

[0049] Example 3

[0050] The method steps for setting a protective layer on the tube wall of the peritoneal dialysis tube body proposed by the present invention are as follows:

[0051] S1: Acidify the tube body and then add a polyethyleneimine solution for amination modification;

[0052] S2: Immerse the amination-modified tube body in S1 into the first protective liquid, take it out and dry it, then immerse it in the second protective liquid. Repeat the immersion in the first protective liquid and the second protective liquid 6 times to form a protective layer on the tube wall of the tube body.

[0053] In S1, acidification is carried out with a potassium permanganate - concentrated sulfuric acid solution, and the mass fraction of the concentrated sulfuric acid solution is 60%; the mass concentration of the polyethyleneimine solution is 0.08%.

[0054] In S2, the first protective liquid is a polysaccharide solution with a mass concentration of 30 g / L. The polysaccharide is composed of polygonatum polysaccharide, rhodophyta polysaccharide and auricularia auricula polysaccharide in a mass ratio of 1:2:2. The temperature for each immersion in the first protective liquid is 50 °C and the time is 30 min. The second protective liquid is composed of methacryloxypropylcaged polysilsesquioxane and polydimethylsiloxane in a mass ratio of 1:3. The temperature for each immersion in the second protective liquid is 60 °C and the time is 20 min.

[0055] All other conditions are the same as those in Example 1.

[0056] Comparative Example 1

[0057] The polysaccharide in this solution is composed of polygonatum polysaccharide and rhodophyta polysaccharide in a mass ratio of 1:1. All other conditions are the same as those in Example 1.

[0058] Comparative Example 2

[0059] The polysaccharide in this solution is composed of polygonatum polysaccharide and auricularia auricula polysaccharide in a mass ratio of 1:1. All other conditions are the same as those in Example 1.

[0060] Comparative Example 3

[0061] The polysaccharide in this solution is composed of rhodophyta polysaccharide and auricularia auricula polysaccharide in a mass ratio of 1:1. All other conditions are the same as those in Example 1.

[0062] Comparative Example 4

[0063] The method steps for setting a protective layer on the tube wall of the peritoneal dialysis tube in this solution are as follows:

[0064] S1: Acidify the tube body and then add a polyethyleneimine solution for amination modification;

[0065] S2: Immerse the tube body after amination modification in S1 in the first protective liquid, take it out and dry it, and then repeat the immersion in the first protective liquid 4 times.

[0066] In S1, acidification is carried out with a potassium permanganate - concentrated sulfuric acid solution, and the mass fraction of the concentrated sulfuric acid solution is 45%; the mass concentration of the polyethyleneimine solution is 0.06%.

[0067] In S2, the first protective liquid is a polysaccharide solution with a mass concentration of 20 g / L. The polysaccharide is composed of polygonatum polysaccharide, rhodophyta polysaccharide and auricularia auricula polysaccharide in a mass ratio of 1:1:1. The temperature for each immersion in the first protective liquid is 40 °C and the time is 20 min.

[0068] Comparative Example 5

[0069] The method steps for setting a protective layer on the tube wall of the peritoneal dialysis tube in this solution are as follows:

[0070] S1: Acidify the tube body and then add polyethyleneimine solution for amino modification.

[0071] S2: Immerse the tube body after amino modification in S1 into the second protective liquid, take it out and dry it, and then repeat the immersion in the second protective liquid 4 times.

[0072] In S1, acidification is carried out with potassium permanganate - concentrated sulfuric acid solution, and the mass fraction of the concentrated sulfuric acid solution is 45%; the mass concentration of the polyethyleneimine solution is 0.06%.

[0073] In S1, the second protective liquid is composed of methacryloxypropylcage polyhedral oligomeric silsesquioxane and polydimethylsiloxane in a mass ratio of 1:1. The temperature for each immersion in the second protective liquid is 50°C and the time is 15 min.

[0074] Test the anticoagulant performance of the peritoneal dialysis tubes prepared in Examples 1 - 3 and Comparative Examples 1 - 5. The specific method is as follows: Cut the peritoneal dialysis tube body into a size of 0.5 cm × 0.5 cm and place it in a 24 - well culture plate. Then, add 600 μL of platelet - poor plasma to each sample well, incubate it in a 37°C constant - temperature water bath for 2 h, and measure the plasma thromboplastin time, prothrombin time, and thrombin time. The results are shown in Table 1.

[0075] Table 1 Test results of anticoagulant performance

[0076] Group Thromboplastin time (s) Prothrombin time (s) Thrombin time (s) Example 1 106.5 28.3 74.9 Example 2 90.2 21.4 68.1 Example 3 101.3 26.5 72.8 Comparative Example 1 61.6 18.5 48.0 Comparative Example 2 64.1 19.2 45.9 Comparative Example 3 62.4 18.9 47.3 Comparative Example 4 50.6 15.8 36.1 Comparative Example 5 42.1 13.7 29.5

[0077] It can be seen from the test results of Example 1 and Comparative Examples 1 - 3 that the present invention has a good anticoagulant effect by forming a protective layer on the peritoneal dialysis tube. Moreover, the polysaccharide in the first protective liquid of the present invention is composed of polygonatum polysaccharide, red algae polysaccharide, and auricularia auricula polysaccharide, which has a synergistic promoting effect on improving the anticoagulant performance of the peritoneal dialysis tube. In addition, by immersing the second protective liquid in a layer - by - layer self - assembly manner, under the action of the self - crosslinking agent of the tube body, a cross - linked network structure can be formed, which not only improves the smoothness of the tube wall surface but also further improves the anticoagulant effect of the tube body.

Claims

1. A peritoneal dialysis device, characterized in that The peritoneal dialysis device comprises a peritoneal dialysis assembly and a peritoneal dialysis tube detachably connected to the peritoneal dialysis assembly; the peritoneal dialysis assembly comprises a dialysate bag (1), a drainage bag (4) and a three-way joint (6); the dialysate bag (1) is provided with a liquid inlet joint (2); the dialysate bag (1) is connected to the three-way joint (6) via an infusion tube (3); the drainage bag (4) is connected to the three-way joint (6) via a drainage tube (5); the three-way joint (6) is further connected to a connecting tube (9); a connecting joint (7) is provided at one end of the connecting tube (9) away from the three-way joint (6); a protective cap (8) is sleeved on the connecting joint (7); The peritoneal dialysis tube comprises a tube body (10), and the tube wall of the tube body (10) is provided with a protective layer; The method steps for providing a protective layer on the wall of the tube body (10) are as follows: S1: Acidify the tube body and then add polyethyleneimine solution for amino modification; S2: immersing the tube body modified by amino in S1 into the first protective solution, taking it out and drying it, and then immersing it into the second protective solution. Repeating the immersion into the first protective solution and the second protective solution 3-6 times can form a protective layer on the tube wall of the tube body; The first protective solution in S2 is a polysaccharide solution with a mass concentration of 10-30 g / L, and the polysaccharide is composed of polygonatum polysaccharide, red algae polysaccharide and black fungus polysaccharide in a mass ratio of 2:1-4:1-4.

2. The peritoneal dialysis device according to claim 1, characterized in that The protective cap (8) comprises a sleeve (81), a slot (82) is provided at the bottom of the sleeve (81), a top block (83) is formed by providing a mounting slot at the top of the sleeve (81), a pull block (84) arranged in a triangular shape is fixedly connected to the outer walls of both sides of the sleeve (81) near the lower end, a pull ring (85) is fixedly connected to the side of the pull block (84) away from the sleeve (81), one end of the connecting joint (7) is inserted into the slot (82), and the top block (83) is inserted into the inside of the connecting joint (7).

3. The peritoneal dialysis device according to claim 2, characterized in that: The outer side walls of the casing (81) on both sides near the bottom end are fixedly connected with symmetrically arranged support rods (86); the side of the support rods (86) away from the casing (81) is fixedly connected with a vertical plate (87); the side of the vertical plate (87) facing the lower end is fixedly connected with an elastic telescopic rod (88); the output end of the elastic telescopic rod (88) is fixedly connected with a clamping plate (89); the clamping plate (89) and the vertical plate (87) are both fixedly connected with a spring (810); and the spring (810) is movably sleeved on the outside of the elastic telescopic rod (88).

4. The peritoneal dialysis device according to claim 3, characterized in that: A soft cushion (812) is fixedly connected to one side of the clamping plate (89) away from the elastic telescopic rod (88); the clamping plate (89) is arranged at the bottom end of the sleeve (81) in an arc shape as a whole.

5. The peritoneal dialysis device according to claim 2, characterized in that: A sealing ring (811) is fixedly connected to the inner side wall of the slot (82).

6. The peritoneal dialysis device according to claim 1, characterized in that: A plurality of dialysis holes (13) are formed at one end of the tube body (10), and an end of the tube body (10) away from the dialysis holes (13) is detachably connected to the connecting joint (7). The tube body (10) is also provided with a first ring (11) and a second ring (12) which are spaced apart.

7. The peritoneal dialysis device according to claim 6, characterized in that: The tube body (10) is made of a cross-linked ethylene-octene copolymer doped with barium sulfate powder.

8. The peritoneal dialysis device according to claim 1, characterized in that: S1 is acidified by potassium permanganate-concentrated sulfuric acid solution, the mass fraction of the concentrated sulfuric acid solution is 30-60%; the mass concentration of the polyethyleneimine solution is 0.04-0.08%.

9. The peritoneal dialysis device according to claim 1, characterized in that: The temperature of each immersion in the first protective liquid is 30-50°C and the time is 10-30 minutes; the second protective liquid is composed of methacryloxypropyl cage-type polysilsesquioxane and polydimethylsiloxane in a mass ratio of 3:1-9, and the temperature of each immersion in the second protective liquid is 40-60°C and the time is 10-20 minutes.

Images