A point-of-care test kit for differential diagnosis of respiratory viruses

Abstract

The present invention relates to the field of biological detection, and specifically discloses an instant detection kit for differential diagnosis of respiratory viruses, comprising a working shell, a detection shell detachably connected to the working shell, a connecting component provided on the detection shell, a plurality of detection components connected to the connecting component provided on the detection shell, a limited flow component provided on the connecting component; a rotating component filled with a buffer is connected between the working shell and the connecting component. The present invention can achieve the purpose of mixed detection of multiple viruses of multiple infected persons, can achieve the effect of integrated detection of the kit, reduce the participation of medical staff, reduce the labor intensity of medical staff, improve the detection efficiency, and the detection operations are all carried out in a closed environment, reducing the phenomenon of buffer splashing, reducing the possibility of virus leakage, reducing the phenomenon of cross infection among people, and at the same time disinfecting the kit, which is conducive to the control of the virus epidemic.

Description

Technical Field

[0001] The present invention relates to the field of biological detection technology, and in particular to an instant detection kit for differential diagnosis of respiratory viruses. Background Art

[0002] With the frequent occurrence of respiratory infectious diseases around the world, such as influenza A virus, influenza B virus, new coronavirus and other highly contagious viruses, the demand for rapid and accurate identification of multiple pathogens is becoming increasingly urgent. When detecting respiratory viruses, the latex method is generally used. The latex method is a commonly used immunological detection method that uses the antibodies on the latex particles to specifically bind to the corresponding antigens in the sample to be tested, thereby forming a visible agglutination phenomenon for qualitative detection.

[0003] In the existing patent CN220171052U, a multiple virus antigen joint detection kit is disclosed, including a bottom plate, a top cover and multiple test strips corresponding to different virus antigens, a plurality of placement slots are provided on the bottom plate, and the plurality of placement slots are distributed in a circle with the center of the bottom plate as the center of the circle, and the test strips are placed in the placement slots, and the test strips include a lining plate and a sample pad, a colloidal gold pad, a detection pad and a water-absorbing pad arranged on the lining plate in sequence, and the detection pad is provided with a detection line and a quality control line, and the top cover is provided on the bottom plate, and a plurality of observation holes for the detection line and the quality control line of the test strips are provided on the top cover, and a sample hole is provided in the middle of the top cover, and one end of the sample pad of the multiple test strips is placed at the sample hole. The test strips corresponding to different viruses are assembled on the same test kit, so that the antigens of multiple different viruses can be detected on the same test kit, and rapid identification and detection can be achieved, which is convenient for the detection personnel to view the test results without confusion.

[0004] In the above structure, different viruses can be detected for individuals. However, when detecting the virus, especially during the mixed test, the medical staff needs to shake the buffer solution after it comes into contact with the sample, which can easily cause the buffer solution to splash out. When there are viruses in the sample, cross infection may occur. At the same time, when the buffer solution is dripped into the antigen, it is easy to cause the buffer solution to splash out due to carelessness, making it difficult to form an integrated virus detection effect, increasing the labor intensity of medical staff, and greatly reducing the detection efficiency. At the same time, excessive participation of medical staff increases the possibility of virus leakage.

[0005] Therefore, how to provide a prompt detection kit for differential diagnosis of respiratory viruses is an urgent problem to be solved by those skilled in the art. Summary of the invention

[0006] An object of the present invention is to provide a prompt detection kit for differential diagnosis of respiratory viruses. The prompt detection kit for differential diagnosis of respiratory viruses described in the present invention comprises a working shell, a detection shell is detachably connected to the working shell, a connecting component is arranged on the detection shell, a plurality of detection components connected to the connecting component are arranged on the detection shell, and a limited flow component is arranged on the connecting component;

[0007] A rotating assembly filled with a buffer is connected between the working housing and the connecting assembly, the rotating assembly is connected with the connecting assembly, and a driving mechanism is provided on the working housing, the driving mechanism is used to drive the rotating assembly to rotate;

[0008] The rotating assembly is provided with an expansion assembly, the rotating assembly is provided with a puncture assembly, and the rotating assembly is provided with a disinfection assembly adapted to the puncture assembly;

[0009] Wherein, when the expansion component is in the first state, the expansion component seals the entrance of the rotating component; when the expansion component is in the second state, the expansion component pushes the flow limiting component to release the buffer; when the expansion component is in the third state, the expansion component forces the puncture component to puncture the disinfection component.

[0010] Preferably, the detection housing is provided with a marking ring plate for attaching a label, the working housing is provided with an external thread structure, and the marking ring plate is provided with an internal thread structure threadably connected to the external thread structure.

[0011] Preferably, the detection component includes a base shell arranged on the detection shell, a supporting plate is arranged inside the base shell, a sample loading paper is arranged on the supporting plate, the sample loading paper is connected to a sensitized latex polyester film, the sensitized latex polyester film is connected to a detection paper, the detection paper is connected to absorbent paper, and the detection paper is provided with a detection line and a quality control line.

[0012] Preferably, the connecting component includes a supporting column arranged on the detection shell, a circular connecting tube is arranged on the supporting column, a plurality of shunt tubes are arranged on the circular connecting tube, the shunt tubes pass through the detection shell, the base shell and the supporting plate, the output end of the shunt tube is connected with the sample paper, a connecting tube is arranged on the circular connecting tube, and the current limiting component is arranged in the connecting tube.

[0013] Preferably, the flow limiting assembly includes a flow limiting tube arranged in the connecting tube, a plurality of liquid holes are opened at both ends of the flow limiting tube, a spring 1 is arranged on the inner wall of the flow limiting tube, and the free end of the spring 1 is connected to a flow limiting ball adapted to the liquid hole.

[0014] Preferably, the rotating assembly includes a delivery tube connected to the working shell by a bearing, the delivery tube is connected to an inner rotating tube connected to the delivery tube, the connecting tube is connected to an outer rotating tube matched with the inner rotating tube by a bearing, the inner rotating tube is located inside the working shell, the outer rotating tube is located inside the detection shell, the end of the inner rotating tube is rotatably connected to the end of the outer rotating tube, and a sealing ring is provided at the end of the inner rotating tube.

[0015] Preferably, the driving mechanism includes a motor mounted on the working housing, the output shaft of the motor is connected to a driving gear, the driving gear passes through the working housing, the outer ring fixed sleeve of the inner rotating tube is provided with a driven gear meshing with the driving gear, and the driven gear is located between the inner rotating tube and the working housing.

[0016] Preferably, the expansion assembly includes an air pump installed on the inner rotating tube, the output end of the air pump is provided with an air tube that passes through the inner rotating tube, the inner wall of the inner rotating tube is provided with an expansion airbag connected to the air tube, the expansion airbag is arranged in a ring shape to form an annular channel, the expansion airbag is provided with a pressure relief valve, and the end of the expansion airbag is provided with a push plug.

[0017] Preferably, the puncture assembly includes a plurality of support plates arranged on the inner wall of the inner rotating tube, a slide rod penetrating the support plate is slidably arranged on the support plate, a puncture needle is arranged at the end of the slide rod, a contact plate matched with the push plug is arranged at the other end of the slide rod, and a spring 2 is arranged between the contact plate and the support plate and is sleeved on the outer ring of the puncture needle.

[0018] Preferably, the disinfection assembly includes a plurality of mounting frames arranged on the inner wall of the outer rotating tube, a disinfection balloon filled with disinfectant is arranged in the mounting frame, and a needle hole compatible with the sliding rod and the puncture needle is opened on the mounting frame, and when the puncture needle passes through the needle hole, the disinfection balloon is punctured.

[0019] The beneficial effects of the present invention are as follows:

[0020] When facing the simultaneous detection of multiple different viruses, such as the epidemic of influenza A virus, influenza B virus, and new coronavirus, the present invention prepares a corresponding set of detection components, installs the detection shell, the connecting component, the detection component and the current limiting component on the working shell, until the rotating components are connected to each other to form a whole, and the buffer solution is placed inside the rotating component. At this time, the current limiting component will limit the flow of the buffer solution; the expansion component is started to force the expansion component to be in the first state, so that the expansion component seals the rotating component to prevent the buffer solution from being contaminated, and the device is transported to the detection area, the queued personnel are detected, and the expansion component is opened to insert one or more samples of infected persons. The sample is placed in the rotating component through the entrance of the rotating component, and the rotating component is sealed again by the expansion component so that the sample contacts the buffer solution. The driving mechanism is started to force the rotating component to rotate. After the sample contacts the buffer solution fully, the expansion component is started again to force the expansion component to be in the second state, so that the expansion component compresses the air in the rotating component, and the air pressure in the rotating component increases until the current limiting component releases the buffer solution. The buffer solution is continuously flowed out through the action of the connecting component, and the buffer solution is forced to flow to the detection component. After the detection component reacts to the virus carried by the infected person and displays it, the virus carried by the infected person is judged according to the detection component and recorded. The medical staff will The infected person is processed further according to the situation; the expansion component is continued to be started, and the expansion component is forced to be in the third state, so that the expansion component continues to compress the air in the rotating component, and the expansion component moves to contact the puncture component, forcing the puncture component to puncture the disinfection component, so that the disinfectant in the disinfection component is released, and at the same time, when the pressure increases, the current limiting component releases the disinfectant, and the disinfectant is released into the detection component through the connecting component, thereby achieving the disinfection of the detection component and the rotating component. After completion, the expansion component is forced to return to the first state. After completing the detection of the people in the area, the detection kit is transferred to the detection party, the detection shell, the connecting component, the detection component and the current limiting component are removed, and the following One-step processing, such as preservation or destruction, and the working shell, expansion component, puncture component, rotating component and drive component are disinfected and cleaned for reuse; in summary, the instant detection kit for respiratory virus differential diagnosis of the present application can achieve the purpose of mixed testing of multiple viruses of multiple infected persons, can achieve the effect of integrated detection of the kit, reduce the participation of medical staff, reduce the labor intensity of medical staff, greatly improve the detection efficiency, and the detection operations are all carried out in a closed environment, reducing the splashing of buffer solution, reducing the possibility of virus leakage, reducing the phenomenon of cross-infection among people, and at the same time, the kit is disinfected, which is conducive to the control of the virus epidemic. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0022] Figure 1 It is a three-dimensional structure entity diagram of the present invention;

[0023] Figure 2 An exploded view of the present invention;

[0024] Figure 3 It is a physical diagram of the internal structure of the present invention;

[0025] Figure 4 A structural entity diagram of a connected component of the present invention;

[0026] Figure 5 It is a structural entity diagram of the current limiting component of the present invention;

[0027] Figure 6 A structural entity diagram of the detection assembly of the present invention;

[0028] Figure 7 It is a structural entity diagram of the driving mechanism of the present invention;

[0029] Figure 8 It is a structural entity diagram of the expansion assembly of the present invention;

[0030] Fig. 9 It is a structural entity diagram of the puncture assembly of the present invention;

[0031] Fig.10 It is a structural entity diagram of the disinfection component of the present invention.

[0032] In the figure: 1, working shell; 2, detection shell; 201, marking ring plate; 202, external thread structure; 203, internal thread structure; 301, support column; 302, circular connecting pipe; 303, shunt pipe; 304, connecting pipe; 401, base shell; 402, supporting plate; 403, sample paper; 404, sensitized latex polyester film; 405, detection paper; 406, absorbent paper; 407, detection line; 408, quality control line; 501, flow limiting tube; 502, liquid hole; 503, spring 1; 504, flow limiting Sphere; 601, delivery tube; 602, inner rotating tube; 603, outer rotating tube; 604, sealing ring; 701, motor; 702, driving gear; 703, driven gear; 801, inflation pump; 802, inflation tube; 803, inflatable airbag; 804, annular channel; 805, pressure relief valve; 806, push plug; 901, support plate; 902, slide rod; 903, puncture needle; 904, contact plate; 905, spring 2; 1001, installation frame; 1002, disinfection balloon; 1003, needle hole. DETAILED DESCRIPTION

[0033] The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, which only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.

[0034] Embodiment 1:

[0035] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Fig. 9 and Fig.10 As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention comprises a working shell 1, a detection shell 2 is detachably connected to the working shell 1, a connecting component is arranged on the detection shell 2, a plurality of detection components connected to the connecting component are arranged on the detection shell 2, and a limited flow component is arranged on the connecting component;

[0036] A rotating assembly filled with a buffer is connected between the working housing 1 and the connecting assembly, the rotating assembly is connected to the connecting assembly, and a driving mechanism is provided on the working housing 1, the driving mechanism is used to drive the rotating assembly to rotate;

[0037] An expansion component is arranged on the rotating component, a puncture component is arranged inside the rotating component, and a disinfection component adapted to the puncture component is arranged inside the rotating component;

[0038] Among them, when the expansion component is in the first state, the expansion component seals the entrance of the rotating component; when the expansion component is in the second state, the expansion component pushes the flow limiting component to release the buffer; when the expansion component is in the third state, the expansion component forces the puncture component to puncture the disinfection component.

[0039] Working principle: When facing the simultaneous detection of multiple different viruses, such as the epidemic of influenza A virus, influenza B virus, and new coronavirus, prepare a corresponding set of detection components, install the detection shell 2, connecting component, detection component and current limiting component on the working shell 1, until the rotating components are connected to each other to form a whole, and put the buffer solution into the rotating component. At this time, the current limiting component will limit the flow of the buffer solution; start the expansion component to force the expansion component to be in the first state, so that the expansion component seals the rotating component to prevent the buffer solution from being contaminated, transport the device to the detection area, detect the queued personnel, open the expansion component, and put one or more infected people in the detection area. The sample is put into the rotating component through the entrance of the rotating component, and the rotating component is sealed again by the expansion component so that the sample contacts the buffer solution. The driving mechanism is started to force the rotating component to rotate. After the sample contacts the buffer solution fully, the expansion component is started again to force the expansion component to be in the second state, so that the expansion component compresses the air in the rotating component, so that the air pressure in the rotating component increases until the flow limiting component releases the buffer solution, and the buffer solution is continuously flowed out through the action of the connecting component, forcing the buffer solution to flow to the detection component. After the detection component reacts to the virus carried by the infected person, the virus carried by the infected person is judged according to the detection component and recorded. The medical staff Take the next step of processing for the infected person according to the situation; continue to start the expansion component, force the expansion component to be in the third state, so that the expansion component continues to compress the air in the rotating component, and the expansion component moves to contact the puncture component, forcing the puncture component to puncture the disinfection component, so that the disinfectant in the disinfection component is released, and at the same time, when the pressure increases, the current limiting component releases the disinfectant, and releases the disinfectant into the detection component through the connecting component, thereby achieving disinfection of the detection component and the rotating component. After completion, the expansion component is forced to return to the first state. After completing the detection of the people in the area, the detection kit is transferred to the detection party, the detection housing 2, the connecting component, the detection component and the current limiting component are removed, and the following One-step processing, such as preservation or destruction, and the working shell 1, expansion component, puncture component, rotation component and drive component are disinfected and cleaned for reuse; in summary, the instant detection kit for respiratory virus differential diagnosis of the present application can achieve the purpose of mixed testing of multiple viruses of multiple infected persons, can achieve the effect of integrated detection of the kit, reduce the participation of medical staff, reduce the labor intensity of medical staff, greatly improve the detection efficiency, and the detection operations are all carried out in a closed environment, reducing the splashing of buffer solution, reducing the possibility of virus leakage, reducing the phenomenon of cross-infection among people, and at the same time, the kit is disinfected, which is conducive to the control of the virus epidemic.

[0040] Embodiment 2:

[0041] like Figure 1 and Figure 2As shown, a rapid detection kit for respiratory virus differential diagnosis of the present invention is provided with a labeling ring plate 201 on the detection shell 2, an external thread structure 202 is provided on the working shell 1, and an internal thread structure 203 threadably connected to the external thread structure 202 is provided on the marking ring plate 201.

[0042] like Figure 1 , Figure 2 , Figure 3 and Figure 6 As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention, the detection component includes a base shell 401 arranged on the detection shell 2, a supporting plate 402 is arranged in the base shell 401, a sample adding paper 403 is arranged on the supporting plate 402, the sample adding paper 403 is connected to a sensitized latex polyester film 404, the sensitized latex polyester film 404 is connected to a detection paper 405, the detection paper 405 is connected to an absorbent paper 406, and the detection paper 405 is provided with a detection line 407 and a quality control line 408.

[0043] like Figure 1 , Figure 3 , Figure 4 and Figure 6 As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention, the connecting component includes a support column 301 arranged on the detection shell 2, a circular connecting tube 302 is arranged on the support column 301, a plurality of shunt tubes 303 are arranged on the circular connecting tube 302, the shunt tube 303 passes through the detection shell 2, the base shell 401 and the supporting plate 402, the output end of the shunt tube 303 is connected to the sample paper 403, a connecting tube 304 is arranged on the circular connecting tube 302, and the current limiting component is arranged in the connecting tube 304.

[0044] like Figure 3 , Figure 4 and Figure 5 As shown, a rapid detection kit for respiratory virus differential diagnosis of the present invention, the flow limiting component includes a flow limiting tube 501 arranged in a connecting tube 304, a plurality of liquid holes 502 are opened at both ends of the flow limiting tube 501, a spring 503 is arranged on the inner wall of the flow limiting tube 501, and the free end of the spring 503 is connected to a flow limiting sphere 504 adapted to the liquid hole 502.

[0045] like Figure 1 , Figure 2 , Figure 3 and Figure 7As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention, the rotating assembly includes a delivery tube 601 connected to a working shell 1 by a bearing, an inner rotating tube 602 connected to the delivery tube 601 is connected to the delivery tube 601, an outer rotating tube 603 matched with the inner rotating tube 602 is connected to a bearing on the connecting tube 304, the inner rotating tube 602 is located inside the working shell 1, the outer rotating tube 603 is located inside the detection shell 2, the end of the inner rotating tube 602 is rotatably plugged with the end of the outer rotating tube 603, and a sealing ring 604 is provided at the end of the inner rotating tube 602.

[0046] like Figure 1 , Figure 2 , Figure 3 and Figure 7 As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention, the driving mechanism includes a motor 701 installed on a working shell 1, the output shaft of the motor 701 is connected to a driving gear 702, the driving gear 702 passes through the working shell 1, the outer ring fixed sleeve of the inner rotating tube 602 is provided with a driven gear 703 meshing with the driving gear 702, and the driven gear 703 is located between the inner rotating tube 602 and the working shell 1.

[0047] like Figure 2 , Figure 3 , Figure 7 and Figure 8 As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention, the expansion component includes an air pump 801 installed on an inner rotating tube 602, the output end of the air pump 801 is provided with an air tube 802 penetrating the inner rotating tube 602, the inner wall of the inner rotating tube 602 is provided with an expansion airbag 803 connected to the air tube 802, the expansion airbag 803 is arranged in a ring shape to form an annular channel 804, the expansion airbag 803 is provided with a pressure relief valve 805, and the end of the expansion airbag 803 is provided with a push plug 806.

[0048] like Figure 2 , Figure 3 , Figure 7 , Figure 8 and Fig. 9 As shown, a prompt detection kit for respiratory virus differential diagnosis of the present invention, the puncture component includes a plurality of support plates 901 arranged on the inner wall of the inner rotating tube 602, a slide bar 902 penetrating the support plate 901 is slidably arranged on the support plate 901, a puncture needle 903 is arranged at the end of the slide bar 902, a contact plate 904 adapted to the push plug 806 is arranged at the other end of the slide bar 902, and a spring 905 sleeved on the outer ring of the puncture needle 903 is arranged between the contact plate 904 and the support plate 901.

[0049] like Figure 2 , Figure 3 , Fig. 9 and Fig.10 As shown, a rapid detection kit for respiratory virus differential diagnosis of the present invention, the disinfection component includes a plurality of mounting frames 1001 arranged on the inner wall of the outer rotating tube 603, a disinfection balloon 1002 filled with disinfectant is arranged in the mounting frame 1001, and a needle hole 1003 compatible with the sliding rod 902 and the puncture needle 903 is opened on the mounting frame 1001. When the puncture needle 903 passes through the needle hole 1003, the disinfection balloon 1002 is punctured.

[0050] Working principle: When facing the simultaneous detection of multiple different viruses, such as influenza A virus, influenza B virus, and new coronavirus, antibodies of influenza A virus, influenza B virus, and new coronavirus are fixed on the sensitized latex polyester film 404, and different antibodies are respectively fixed on the latex particles of different sensitized latex polyester films 404, and installed in the base shell 401 in the order of the sample paper 403, sensitized latex polyester film 404, detection paper 405, and absorbent paper 406 on the support plate 402, and installed on the detection paper 405 in the order of detection line 407 and quality control line 408 to form different detection reagents, and fixed on the detection shell 2;

[0051] According to the popular virus, under the action of the internal thread structure 203 and the external thread structure 202, the marking ring plate 201 is rotated to force the detection housing 2 to be connected to the working housing 1, until the outer rotating tube 603 and the inner rotating tube 602 are plugged together, and under the action of the sealing ring 604, the outer rotating tube 603 and the inner rotating tube 602 are tightly connected to form a whole;

[0052] The buffer solution is placed into the outer rotating tube 603 through the placing tube 601. Under the action of the spring 1 503, the flow-limiting sphere 504 blocks the liquid-passing hole 502 on the flow-limiting tube 501 to prevent the buffer solution from flowing out into the connecting tube 304. The air pump 801 is started. Under the action of the air-filling tube 802, the gas is continuously filled into the expansion airbag 803, so that the expansion airbag 803 expands to the first state, so that the annular channel 804 is closed, and the placing tube 601 is closed to prevent the buffer solution from being contaminated. The device is transported to the detection area to detect the queued personnel.

[0053] The pressure relief valve 805 is activated to release the gas in the inflatable airbag 803. At this time, the inflatable airbag 803 shrinks to expose the annular channel 804. The annular channel 804 is aligned with the delivery tube 601. One or more samples of infected persons are delivered into the outer rotating tube 603 through the delivery tube 601 and the annular channel 804, so that the buffer solution is mixed with the sample.

[0054] The air pump 801 is started again, so that the gas is continuously filled into the expansion airbag 803, so that the expansion airbag 803 is expanded to the first state, so that the annular channel 804 is closed, and the motor 701 is started at this time, and the output shaft of the motor 701 rotates to drive the driving gear 702 to rotate, and the driving gear 702 drives the driven gear 703 to rotate, and the driven gear 703 drives the inner rotating tube 602 to rotate. Due to the squeezing effect of the working shell 1 and the detection shell 2, friction is generated between the inner rotating tube 602 and the outer rotating tube 603, and the sealing ring 604 improves the sealing between the inner rotating tube 602 and the outer rotating tube 603. When the inner rotating tube 602 rotates, it drives the outer rotating tube 603 to rotate synchronously, so that the buffer solution rotates in the outer rotating tube 603, so that the buffer solution is fully in contact with the sample;

[0055] The air pump 801 is started continuously, so that the gas is continuously filled into the expansion airbag 803, so that the expansion airbag 803 expands to the second state. At this time, the expansion airbag 803 expands and moves in the inner rotating tube 602, so that the air pressure inside the inner rotating tube 602 and the outer rotating tube 603 increases, until the air pressure lifts up the flow-limiting sphere 504, so that the flow-limiting sphere 504 is separated from the liquid through hole 502, so that the spring 1 503 is compressed, so that the liquid through holes 502 at both ends are connected with the outer rotating tube 603, and the buffer solution flows out of the liquid through hole 502 into the connecting tube 304 and the circular connecting tube 302. Under the action of the shunt tube 303, the buffer solution is introduced onto the sample loading paper 403;

[0056] Through capillary action, the buffer solution continuously passes through the sample paper 403, the sensitized latex polyester film 404, the detection paper 405 and the absorbent paper 406. For example, when a new coronavirus is present, the antigen of the new coronavirus will bind to the antibody on the latex particles of the sensitized latex polyester film 404, thereby reflecting the aggregation of latex particles. Due to the aggregation of latex particles, color appears on the detection line 407, proving that there is a new coronavirus target antigen in the sample, and the result is positive. If no color appears on the detection line 407, it proves that there is no new coronavirus target antigen in the sample, and the result is negative. The color appears on the quality control line 408, proving that it is an effective detection, thereby realizing the detection of the virus by the latex method. According to the result, the type of virus carried by the infected person is determined and recorded, and the mark is affixed to the marking ring plate 201. The medical staff will carry out the next step of processing on the infected person or the infected group according to the situation;

[0057] After the treatment, due to the continuous outflow of the buffer solution, the flow-limiting sphere 504 returns to its original position, continues to block the liquid hole 502, limits the flow of the buffer solution, and continues to start the inflation pump 801, so that the gas is continuously filled into the expansion airbag 803, so that the expansion airbag 803 expands to the third state. At this time, the expansion airbag 803 continues to expand and move in the inner rotating tube 602, and the expansion airbag 803 drives the push plug 806 to move, and the push plug 806 contacts the contact plate 904. The push plug 806 drives the contact plate 904 to move, so that the contact plate 904 drives the slide bar 902 to move on the support plate 901, thereby causing the puncture needle 903 to move, and the spring 905 is compressed, and the puncture needle 903 passes through the needle hole 1003 until the puncture needle 903 punctures the disinfection airbag, causing the disinfectant in the disinfection airbag to flow out, and the disinfectant is inside the external rotating tube 603. The inner and outer rotating tubes 602 and 603 are sterilized, and the expansion movement of the inflatable airbag 803 increases the air pressure inside the inner rotating tube 602 and the outer rotating tube 603 until the air pressure lifts up the flow limiting sphere 504 again, so that the flow limiting sphere 504 is separated from the liquid through hole 502, and the spring 1 503 is compressed, so that the liquid through holes 502 at both ends are connected with the outer rotating tube 603, and the disinfectant flows out from the liquid through hole 502 into the connecting tube 304 and the circular connecting tube 302, and under the action of the shunt tube 303, the disinfectant is introduced onto the sample adding paper 403, and through the capillary phenomenon, under the action of the absorbent paper 406, the disinfectant disinfects the sample adding paper 403, the sensitized latex polyester film 404 and the detection paper 405; thereby, the disinfection of the test kit is realized, and after completion, under the action of the pressure relief valve 805, the inflatable airbag 803 is forced to return to the first state;

[0058] After completing the detection of people in the area, the detection kit is transferred to the detection party, and the detection shell 2, the connecting component, the detection component and the current limiting component are removed through the action of the internal thread structure 203 and the external thread structure 202, and the next step of processing is carried out, such as storage or destruction, and the working shell 1, the expansion component, the puncture component, the rotating component and the driving component are disinfected and cleaned for reuse to achieve the purpose of reuse.

[0059] The setting of the marking ring plate 201 is convenient for medical staff to apply force to the detection shell 2, and labels can be attached to it, which is convenient for medical staff to record virus-infected persons. The setting of the external thread structure 202 and the internal thread structure 203 is convenient for disassembly and installation of the detection shell 2, realizing the function of replacing the detection component, and can provide a clamping force for the inner rotating tube 602 and the outer rotating tube 603; the setting of the detection component can realize the latex method to detect viruses, improve the convenience of virus detection, achieve the purpose of rapid differential diagnosis of respiratory viruses, and can select the test kit according to the current status of the virus, improve the adaptability of the device, and enable the device to identify multiple viruses; the setting of the connecting component can connect the outer rotating tube 603 with the shunt tube 303 The flow of disinfectant and buffer solution is realized, thereby realizing the detection effect of the virus in the buffer solution, and realizing the disinfection effect of the disinfectant on the detection component and the outer rotating tube 603, reducing the possibility of virus leakage, reducing the phenomenon of cross infection among people, and at the same time disinfecting the test kit, which is conducive to the control of the virus epidemic; the setting of the flow limiting component can realize the limiting effect on the flow of the buffer solution and the disinfectant, so that in the process of mixing the buffer solution and the disinfection process of the disinfectant on the outer rotating tube 603, the interception effect of the disinfectant and the buffer solution is guaranteed, and the disinfectant and the buffer solution are prevented from flowing irregularly. At the same time, the flow limiting sphere 504 can be pushed open under the action of pressure to realize the flow effect of the buffer solution and the disinfectant, and the flexibility of the device is improved; the rotating group The arrangement of the components can realize the synchronous rotation of the inner rotating tube 602 and the outer rotating tube 603, so that the buffer solution can fully contact with the sample, so that the virus is contained in the buffer solution, which replaces the shaking action of medical staff and reduces the labor intensity of medical staff. The inner rotating tube 602 and the outer rotating tube 603 can be disassembled, which is conducive to the reuse of the device and the processing of the detection component. The arrangement of the sealing ring 604 can improve the sealing between the inner rotating tube 602 and the outer rotating tube 603; the arrangement of the driving mechanism can provide a rotating power to realize the rotation effect of the inner rotating tube 602 and the outer rotating tube 603, so that the buffer solution can be shaken and fully contacted with the sample, reducing the labor intensity of medical staff and facilitating the integrated detection of viruses by the device; the arrangement of the expansion component can realize The sealing effect of the delivery tube 601 is now convenient for transporting the buffer solution, ensuring the quality of the buffer solution, and avoiding the buffer solution from splashing out, thereby improving the safety of the device. At the same time, the pressure inside the inner rotating tube 602 and the outer rotating tube 603 can be changed, thereby achieving the top effect on the flow limiting sphere 504, achieving the smooth flow of the buffer solution and the disinfectant, and improving the versatility of the device; the setting of the puncture component can achieve the interaction with the expansion component, thereby generating a force on the puncture needle 903, achieving the reasonable movement of the puncture needle 903, so that the puncture needle 903 interacts with the disinfection component, thereby achieving the control effect on the disinfection component, and the setting of the spring 2 905 can realize the puncture needle 903 to return to its original position, thereby improving the flexibility of the device;The setting of the disinfection component can realize the storage function of the disinfectant, so that when the buffer solution is mixed with the sample, the storage of the disinfectant solution is guaranteed, the contamination of the buffer solution by the disinfectant solution is avoided, the detection of the buffer solution is guaranteed, and the accuracy of the device is improved. At the same time, when the disinfection balloon 1002 is punctured, the disinfectant solution can be effectively realized, thereby realizing the disinfection of the test kit, reducing the possibility of virus leakage, reducing the phenomenon of cross infection among people, and facilitating the control of the virus epidemic. ;

[0060] This solution uses the latex method to achieve the purpose of mixed testing of multiple viruses in multiple infected persons, can achieve the effect of integrated testing of the test kit, reduce the participation of medical staff, reduce the labor intensity of medical staff, and greatly improve the detection efficiency. From the placement of samples to the preservation or destruction of samples, the test kit is carried out in a closed environment, which reduces the splashing of buffer solution, improves the sealing effect of the device, reduces the possibility of virus leakage, and reduces the phenomenon of cross-infection among people. At the same time, the test kit is disinfected, which is conducive to the control of the virus epidemic.

[0061] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A real-time detection kit for differential diagnosis of respiratory viruses, characterized in that: Comprising a working housing (1), the working housing (1) being detachably connected to a detection housing (2), the detection housing (2) being provided with a communication component, the detection housing (2) being provided with a plurality of detection components connected to the communication component, the communication component being provided with a limited flow component; A rotating assembly containing a buffer is connected between the working housing (1) and the connecting assembly, the rotating assembly is connected to the connecting assembly, and a driving mechanism is provided on the working housing (1), the driving mechanism being used to drive the rotating assembly to rotate; The rotating assembly is provided with an expansion assembly, the rotating assembly is provided with a puncture assembly, and the rotating assembly is provided with a disinfection assembly adapted to the puncture assembly; Wherein, when the expansion component is in the first state, the expansion component seals the entrance of the rotating component; when the expansion component is in the second state, the expansion component pushes the flow limiting component to release the buffer; when the expansion component is in the third state, the expansion component forces the puncture component to puncture the disinfection component; The detection housing (2) is provided with a marking ring plate (201) for attaching a label, the working housing (1) is provided with an external thread structure (202), and the marking ring plate (201) is provided with an internal thread structure (203) threadedly connected to the external thread structure (202); The detection component comprises a base shell (401) arranged on the detection shell (2), a supporting plate (402) being arranged inside the base shell (401), a sample paper (403) being arranged on the supporting plate (402), a sensitized latex polyester film (404) being connected to the sample paper (403), a detection paper (405) being connected to the sensitized latex polyester film (404), a water-absorbing paper (406) being connected to the detection paper (405), and a detection line (407) and a quality control line (408) being arranged on the detection paper (405); The connecting component comprises a support column (301) arranged on the detection housing (2), a circular connecting tube (302) being arranged on the support column (301), a plurality of shunt tubes (303) being arranged on the circular connecting tube (302), the shunt tubes (303) passing through the detection housing (2), the base housing (401) and the supporting plate (402), the output end of the shunt tube (303) being connected to the sample adding paper (403), a connecting tube (304) being arranged on the circular connecting tube (302), and the current limiting component being arranged in the connecting tube (304); The flow limiting assembly comprises a flow limiting tube (501) arranged in the connecting tube (304), a plurality of liquid through holes (502) are provided at both ends of the flow limiting tube (501), a spring 1 (503) is provided on the inner wall of the flow limiting tube (501), and a flow limiting ball (504) adapted to the liquid through hole (502) is connected to the free end of the spring 1 (503); The rotating assembly comprises a delivery tube (601) connected to the working housing (1) by a bearing, the delivery tube (601) is connected to an inner rotating tube (602) communicating with the delivery tube (601), the communicating tube (304) is connected to an outer rotating tube (603) matched with the inner rotating tube (602) by a bearing, the inner rotating tube (602) is located inside the working housing (1), the outer rotating tube (603) is located inside the detection housing (2), an end of the inner rotating tube (602) is rotatably plugged into an end of the outer rotating tube (603), and a sealing ring (604) is provided at the end of the inner rotating tube (602); The expansion assembly comprises an air pump (801) mounted on the inner rotating tube (602); an air tube (802) penetrating the inner rotating tube (602) is provided at the output end of the air pump (801); an expansion air bag (803) connected to the air tube (802) is provided on the inner wall of the inner rotating tube (602); the expansion air bag (803) is arranged in an annular shape to form an annular channel (804); a pressure relief valve (805) is provided on the expansion air bag (803); and a push plug (806) is provided at the end of the expansion air bag (803).

2. A prompt detection kit for differential diagnosis of respiratory viruses according to claim 1, characterized in that: The driving mechanism comprises a motor (701) mounted on the working housing (1); an output shaft of the motor (701) is connected to a driving gear (702); the driving gear (702) passes through the working housing (1); an outer ring fixed sleeve of the inner rotating tube (602) is provided with a driven gear (703) meshing with the driving gear (702); the driven gear (703) is located between the inner rotating tube (602) and the working housing (1).

3. A real-time detection kit for differential diagnosis of respiratory viruses according to claim 2, characterized in that: The puncture assembly includes a plurality of support plates (901) arranged on the inner wall of the inner rotating tube (602), a slide rod (902) penetrating the support plate (901) is slidably arranged on the support plate (901), a puncture needle (903) is arranged at the end of the slide rod (902), a contact plate (904) adapted to the push plug (806) is arranged at the other end of the slide rod (902), and a spring 2 (905) sleeved on the outer ring of the puncture needle (903) is arranged between the contact plate (904) and the support plate (901).

4. A prompt detection kit for differential diagnosis of respiratory viruses according to claim 3, characterized in that: The disinfection assembly comprises a plurality of mounting frames (1001) arranged on the inner wall of the outer rotating tube (603), wherein a disinfection balloon (1002) filled with disinfectant is arranged in the mounting frame (1001), and a needle hole (1003) adapted to the sliding rod (902) and the puncturing needle (903) is provided on the mounting frame (1001), and when the puncturing needle (903) passes through the needle hole (1003), the disinfection balloon (1002) is punctured.

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