Automatic reagent release device

Abstract

The invention relates to the technical field of drug release mechanisms, in particular to an automatic reagent release device, which is characterized in that a reagent is sealed in a capsule bin by using an aluminum foil tape, the reagent in the capsule bin is automatically released to a release channel through a release mechanism, and the release channel is communicated with a sample well, so that the reagent can be automatically released. The reagent can enter the sample well along the release channel for reaction, manual operation contact is avoided in the whole process, efficiency is high, operation is convenient, the reagent in the bubble cap cannot be polluted, and the technical problem that the reagent in the bubble cap cannot be automatically released in the prior art is effectively solved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug release mechanisms, and more specifically, to an automatic reagent release device. Background Art

[0002] The important goal of the reagent storage and release mechanism is "sample in, result out". The reagent storage and release mechanism uses reagent reaction operations to obtain diagnostic results. Since there are far more than one reagent involved in the reaction, the reagent storage and release mechanism must have a pre-storage structure for storing reagents. The reagent pre-storage form of the reagent storage and release mechanism is divided into dry powder and liquid form. However, the release of the traditional reagent storage and release mechanism needs to be opened manually, which makes the diagnostic efficiency of the reagent storage and release mechanism low and the convenience of use poor.

[0003] For example, the prior art has a drug release belt containing blisters, which is installed in a specific drug powder release mechanism and is composed of a base sheet and a cover sheet that are closely attached to each other, wherein the raised portion of the blister is on the base sheet, and the blister of the drug release belt is used to quantitatively store powder or granular drugs. The drug release belt of this scheme optimizes the size and arc angle of the blister in the prior art, making it easier to suck out the drug in the blister, reducing the residual amount of the drug in the blister, and effectively improving the utilization rate of the drug in the blister.

[0004] However, the blister release method of the prior art requires manual opening, which is not only inefficient and inconvenient to operate, but also easily contaminates the reagent in the blister during manual release, and there is a technical problem that the reagent in the blister cannot be automatically released. Summary of the invention

[0005] The purpose of the present invention is to overcome the deficiency of the prior art that the reagent in the blister cannot be automatically released, and to provide a reagent automatic releasing device.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0007] A reagent automatic releasing device comprises a sample reaction plate, a capsule chamber provided on the sample reaction plate and used for accommodating reagents, a releasing mechanism provided on the sample reaction plate, a releasing channel provided on the sample reaction plate, and a sample well provided on the sample reaction plate and connected to the releasing channel, wherein an opening of the capsule chamber is sealed with an aluminum foil strip, and the releasing mechanism can automatically release the reagent in the capsule chamber to the releasing channel.

[0008] The present invention discloses an automatic reagent releasing device, which uses an aluminum foil strip to seal the reagent in a capsule, and automatically releases the reagent in the capsule to the release channel through a release mechanism. Since the release channel is connected to the sample well, the reagent enters the sample well along the release channel for reaction. There is no manual operation contact in the whole process, which is not only efficient and easy to operate, but also will not contaminate the reagent in the blister, and effectively solves the technical problem in the prior art that the reagent in the blister cannot be automatically released.

[0009] Furthermore, the capsule is a cover box disposed on the sample reaction plate, and the opening of the cover box is disposed obliquely downward toward the release channel; the release mechanism includes a reel rotatably disposed on the sample reaction plate, and a first driving device for driving the reel to rotate, the reel is disposed beside the opening of the cover box, and the aluminum foil tape extends from a side away from the reel and is wound around the outer wall of the reel. Since the reel is rotatably disposed beside the opening of the cover box, and the aluminum foil tape extends from a side away from the reel and is wound around the outer wall of the reel, the reel is driven to rotate by the first driving device, and the aluminum foil tape sealed at the opening of the cover box is gradually torn open, and the opening of the cover box is gradually opened, and since the opening of the cover box is disposed obliquely downward toward the release channel, the reagent in the cover box automatically falls from the opening to the release channel under the action of gravity, thereby realizing the automatic release of the cover box.

[0010] Furthermore, the release channel is recessed on the upper end surface of the sample reaction plate, and the cover box is disposed above the release channel. The release channel is recessed on the upper end surface of the sample reaction plate to prevent the reagent from flowing out of the sample reaction plate; the cover box is disposed above the release channel to provide a height difference for the reagent to flow out automatically.

[0011] Furthermore, the extended portion of the aluminum foil tape is parallel to the portion sealed at the opening of the cover box. The extended portion of the aluminum foil tape is arranged in parallel with the portion sealed at the opening of the cover box, ensuring that the extended portion of the aluminum foil tape pulls the portion of the aluminum foil tape sealed at the opening of the cover box in the direction of tearing the aluminum foil tape away from the opening, making the tearing direction perpendicular to the direction of the opening, reducing the sticking force on the aluminum foil tape, avoiding the aluminum foil tape from breaking, improving the efficiency of tearing the aluminum foil tape, and ensuring the stability of the automatic release of the cover box.

[0012] Furthermore, the angle between the plane of the opening of the cover box and the upper end surface of the sample reaction plate is in the range of 30°-80°. The angle between the plane of the opening of the cover box and the upper end surface of the sample reaction plate is in the range of 30°-80°, so that the reagent can be poured out better.

[0013] Furthermore, the capsule compartment is a groove arranged on the sample reaction plate, the opening of the groove is flush with the upper end surface of the sample reaction plate, and the release channel is connected to the bottom of the groove; the release mechanism includes an extrusion plate arranged above the sample reaction plate and a second driving device for driving the extrusion plate to move up and down, and an extrusion block that can fit with the groove is convexly provided at the bottom of the extrusion plate. The capsule compartment is set as a groove on the sample reaction plate, so that the opening of the groove is flush with the upper end surface of the sample reaction plate, and the release channel is connected to the bottom of the groove, and the extrusion plate is driven to move up and down by the second driving device. Since an extrusion block that can fit with the groove is convexly provided at the bottom of the extrusion plate, the extrusion block squeezes the aluminum foil strip at the opening of the groove into the groove. Since the aluminum foil strip has good deformation ductility, it will not be broken due to being squeezed, and the space in the groove will be compressed, so that the reagent in the groove flows out along the release channel at the bottom, realizing the automatic release of the capsule compartment.

[0014] Furthermore, the shape of the extrusion block is hemispherical. The shape of the extrusion block is set to be hemispherical, so that the aluminum foil strip will not be damaged when the extrusion block extrudes the groove, thereby ensuring the sealing of the groove.

[0015] Furthermore, the capsule is a groove provided on the sample reaction plate, the opening of the groove is parallel to the upper end surface of the sample reaction plate, the release channel is connected to the bottom of the groove and is provided with an inclination, and a steel ball is sealed between the groove and the release channel; the aluminum foil strip is provided with an air hole at the center of the opening of the groove; and the release mechanism can make the steel ball fall into the release channel. The steel ball is sealed between the groove and the release channel. Since the release channel is connected to the bottom of the groove and is provided with an inclination, when the release mechanism makes the steel ball fall into the release channel, the steel ball will roll out of the release channel at the inclination. Since the aluminum foil strip is provided with an air hole at the center of the opening of the groove, the air pressure in the groove is balanced with the outside world, and the reagent can flow from the groove into the release channel to realize the automatic release of the capsule.

[0016] Furthermore, the steel ball is wax-sealed between the groove and the release channel, and the release mechanism is a heating device for heating the steel ball. The steel ball is wax-sealed between the groove and the release channel, and when the heating device heats the steel ball, the wax fixing the steel ball will melt, and the steel ball will fall into the release channel, which has the advantages of simple structure and stable operation.

[0017] Furthermore, the material of the capsule is one or more of polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polypropylene, polyvinyl chloride, ABS, thermoplastic polyurethane elastomer rubber, polystyrene, polysulfone, and transparent nylon. The material of the capsule is set to one or more of polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polypropylene, polyvinyl chloride, ABS, thermoplastic polyurethane elastomer rubber, polystyrene, polysulfone, and transparent nylon to ensure that the capsule can resist the shear stress caused by the separation process from the aluminum foil layer without obvious deformation.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The present invention discloses an automatic reagent releasing device, which uses an aluminum foil strip to seal the reagent in a capsule, and automatically releases the reagent in the capsule to the release channel through a release mechanism. Since the release channel is connected to the sample well, the reagent enters the sample well along the release channel for reaction. There is no manual operation contact in the whole process, which is not only efficient and easy to operate, but also will not contaminate the reagent in the blister, and effectively solves the technical problem in the prior art that the reagent in the blister cannot be automatically released. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic structural diagram of an automatic reagent release device according to Example 1;

[0021] Figure 2 It is a structural schematic diagram of the release mechanism of the first embodiment;

[0022] Figure 3 This is a schematic structural diagram of an automatic reagent release device according to Example 2;

[0023] Figure 4 It is a structural schematic diagram of the release mechanism of the second embodiment;

[0024] Figure 5 This is a schematic structural diagram of an automatic reagent releasing device according to Example 3.

[0025] In the attached drawings: 1. sample reaction plate; 11. release channel; 2. release mechanism; 21. reel; 22. extrusion plate; 23. extrusion block; 3. sample well; 4. aluminum foil strip; 41. air vent; 5. cover box; 6. groove; 7. steel ball. DETAILED DESCRIPTION

[0026] The present invention is further described below in conjunction with specific implementation methods. The accompanying drawings are only used for exemplary descriptions and are only schematic diagrams, not actual drawings, and cannot be understood as limiting this patent; in order to better illustrate the embodiments of the present invention, some parts of the accompanying drawings may be omitted, enlarged or reduced, and do not represent the size of the actual product; for those skilled in the art, it is understandable that some well-known structures and their descriptions in the accompanying drawings may be omitted.

[0027] The same or similar numbers in the drawings of the embodiments of the present invention correspond to the same or similar parts; in the description of the present invention, it should be understood that if the terms "upper", "lower", "left", "right" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, it is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction. Therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and cannot be understood as limitations on this patent. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to specific circumstances.

[0028] Embodiment 1

[0029] like Figure 1 to Figure 2 The figure shows a first embodiment of an automatic reagent releasing device according to the present invention.

[0030] A reagent automatic release device comprises a sample reaction plate 1, a capsule chamber arranged on the sample reaction plate 1 and used to contain a reagent, a release mechanism 2 arranged on the sample reaction plate 1, a release channel 11 arranged on the sample reaction plate 1, and a sample well 3 arranged on the sample reaction plate 1 and connected to the release channel 11, wherein an aluminum foil strip 4 is sealed at the opening of the capsule chamber, and the release mechanism 2 can automatically release the reagent in the capsule chamber to the release channel 11. The capsule chamber is a cover box 5 arranged on the sample reaction plate 1, and the opening of the cover box 5 is arranged obliquely downward toward the release channel 11; the release mechanism 2 comprises a reel 21 rotatably arranged on the sample reaction plate 1, and a first driving device for driving the reel 21 to rotate, the reel 21 is arranged beside the opening of the cover box 5, and the aluminum foil strip 4 extends from a side away from the reel 21 and is wound around the outer wall of the reel 21. The release channel 11 is concavely arranged on the upper end surface of the sample reaction plate 1, and the cover box 5 is arranged above the release channel 11. The extended portion of the aluminum foil strip 4 is parallel to the portion sealed at the opening of the cover box 5. The angle formed between the plane of the opening of the cover box 5 and the upper end surface of the sample reaction plate 1 is in the range of 30°-80°. The material of the capsule is one or more of polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polypropylene, polyvinyl chloride, ABS, thermoplastic polyurethane elastomer rubber, polystyrene, polysulfone, and transparent nylon.

[0031] In this embodiment, if Figure 1As shown, the reagent is sealed in the capsule by using an aluminum foil strip 4, and the reagent in the capsule is automatically released to the release channel 11 through the release mechanism 2. Since the release channel 11 is connected to the sample well 3, the reagent will enter the sample well 3 along the release channel 11 for reaction. There is no manual operation contact in the whole process, which is not only efficient and easy to operate, but also will not contaminate the reagent in the blister, and effectively solves the technical problem of the prior art that the reagent in the blister cannot be automatically released.

[0032] In this embodiment, if Figure 2 As shown, since the reel 21 is rotatably arranged beside the opening of the cover box 5, and the aluminum foil tape 4 extends out from the side away from the reel 21 and is wound around the outer wall of the reel 21, the reel 21 is driven to rotate by the first driving device, and the aluminum foil tape 4 sealed at the opening of the cover box 5 is gradually torn open, and the opening of the cover box 5 is gradually opened. Since the opening of the cover box 5 is tilted downward toward the release channel 11, the reagent in the cover box 5 automatically falls from the opening to the release channel 11 under the action of gravity, thereby realizing the automatic release of the cover box 5.

[0033] In this embodiment, if Figure 1 As shown, the release channel 11 is recessed on the upper end surface of the sample reaction plate 1 to prevent the reagent from flowing out of the sample reaction plate 1; the cover box 5 is arranged above the release channel 11 to provide a height difference for the reagent to flow out automatically.

[0034] In this embodiment, if Figure 2 As shown, the extended portion of the aluminum foil tape 4 is arranged in parallel with the portion sealed at the opening of the cover box 5, ensuring that the pulling effect of the extended portion of the aluminum foil tape 4 on the portion of the aluminum foil tape 4 sealed at the opening of the cover box 5 is in the direction of tearing the aluminum foil tape 4 away from the opening, making the tearing direction perpendicular to the direction of the opening, reducing the sticky force on the aluminum foil tape 4, avoiding the aluminum foil tape 4 from breaking, improving the efficiency of tearing off the aluminum foil tape 4, and ensuring the stability of the automatic release of the cover box 5.

[0035] In this embodiment, the angle formed by the plane of the opening of the cover box 5 and the upper end surface of the sample reaction plate 1 is in the range of 30°-80°, so that the reagent can be poured out better.

[0036] In this embodiment, the material of the capsule is set to one or more of polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polypropylene, polyvinyl chloride, ABS, thermoplastic polyurethane elastomer rubber, polystyrene, polysulfone, and transparent nylon to ensure that the capsule can withstand the shear stress caused by the separation process from the aluminum foil layer without obvious deformation.

[0037] Embodiment 2

[0038] like Figure 3 to Figure 4 The figure shows a second embodiment of an automatic reagent releasing device of the present invention.

[0039] This embodiment is similar to the first embodiment, except that: the capsule is a groove 6 provided on the sample reaction plate 1, the opening of the groove 6 is flush with the upper end surface of the sample reaction plate 1, and the release channel 11 is connected to the bottom of the groove 6; the release mechanism 2 includes a squeeze plate 22 provided above the sample reaction plate 1 and a second driving device for driving the squeeze plate 22 to move up and down, and a squeeze block 23 that can fit with the groove 6 is convexly provided at the bottom of the squeeze plate 22. The squeeze block 23 is hemispherical in shape.

[0040] In this embodiment, if Figure 3 and Figure 4 As shown, the capsule compartment is set as the groove 6 on the sample reaction plate 1, so that the opening of the groove 6 is flush with the upper end surface of the sample reaction plate 1, and the release channel 11 is connected to the bottom of the groove 6, and the second driving device is used to drive the extrusion plate 22 to move up and down. Since the bottom of the extrusion plate 22 is convexly provided with an extrusion block 23 that can fit with the groove 6, the extrusion block 23 squeezes the aluminum foil strip 4 at the opening of the groove 6 into the groove 6. Since the aluminum foil strip 4 has good deformation ductility, it will not be broken due to being squeezed. The space in the groove 6 will be compressed, so that the reagent in the groove 6 will flow out along the release channel 11 at the bottom, thereby realizing the automatic release of the capsule compartment.

[0041] In this embodiment, if Figure 4 As shown, the shape of the extrusion block 23 is set to be hemispherical, so that the aluminum foil strip 4 will not be damaged when the extrusion block 23 extrudes the groove 6, thereby ensuring the sealing inside the groove 6.

[0042] Embodiment 3

[0043] like Figure 5 The third embodiment of an automatic reagent releasing device of the present invention is shown.

[0044] This embodiment is similar to the first embodiment or the second embodiment, except that: the capsule is a groove 6 provided on the sample reaction plate 1, the opening of the groove 6 is parallel to the upper end surface of the sample reaction plate 1, the release channel 11 is connected to the bottom of the groove 6 and is provided with an inclination, and a steel ball 7 is sealed between the groove 6 and the release channel 11; the aluminum foil strip 4 is provided with an air hole at the center of the opening of the groove 6; the release mechanism 2 can make the steel ball 7 fall into the release channel 11. Among them, the steel ball 7 is wax-sealed between the groove 6 and the release channel 11, and the release mechanism 2 is a heating device for heating the steel ball 7.

[0045] In this embodiment, if Figure 5As shown, a steel ball 7 is sealed between the groove 6 and the release channel 11. Since the release channel 11 is connected to the bottom of the groove 6 and is provided with an inclination, when the release mechanism 2 causes the steel ball 7 to fall into the release channel 11, the steel ball 7 will roll out of the release channel 11 at the inclination. Since the aluminum foil strip 4 is provided with an air hole at the center position of the opening of the groove 6, the air pressure in the groove 6 is kept balanced with the outside world, and the reagent can flow from the groove 6 into the release channel 11 to realize the automatic release of the capsule.

[0046] In this embodiment, the steel ball 7 is sealed with wax between the groove 6 and the release channel 11. When the heating device heats the steel ball 7, the wax fixing the steel ball 7 will melt, and the steel ball 7 will fall into the release channel 11, which has the advantages of simple structure and stable operation.

[0047] In the specific contents of the above-mentioned specific implementation methods, the various technical features can be combined in any non-contradictory manner. In order to make the description concise, not all possible combinations of the above-mentioned technical features are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0048] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the embodiments here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A reagent automatic release device, characterized in that: The invention comprises a sample reaction plate (1), a capsule chamber arranged on the sample reaction plate (1) and used for accommodating a reagent, a release mechanism (2) arranged on the sample reaction plate (1), a release channel (11) arranged on the sample reaction plate (1), and a sample well (3) arranged on the sample reaction plate (1) and connected to the release channel (11), wherein an aluminum foil strip (4) is sealed at the opening of the capsule chamber, and the release mechanism (2) can automatically release the reagent in the capsule chamber to the release channel (11).

2. The automatic reagent release device according to claim 1, characterized in that: The capsule is a cover box (5) arranged on the sample reaction plate (1), and the opening of the cover box (5) is arranged to be inclined downward toward the release channel (11); the release mechanism (2) comprises a reel (21) rotatably arranged on the sample reaction plate (1), and a first driving device for driving the reel (21) to rotate, the reel (21) being arranged beside the opening of the cover box (5), and the aluminum foil tape (4) extending from a side away from the reel (21) and being wound around the outer wall of the reel (21).

3. The automatic reagent release device according to claim 2, characterized in that: The release channel (11) is recessed on the upper end surface of the sample reaction plate (1), and the cover box (5) is arranged above the release channel (11).

4. The automatic reagent release device according to claim 2, characterized in that: The extended portion of the aluminum foil tape (4) is parallel to the portion sealed at the opening of the cover box (5).

5. The automatic reagent release device according to claim 2, characterized in that: The angle formed by the plane at the opening of the cover box (5) and the upper end surface of the sample reaction plate (1) is in the range of 30°-80°.

6. The automatic reagent release device according to claim 1, characterized in that: The capsule chamber is a groove (6) arranged on the sample reaction plate (1), the opening of the groove (6) is flush with the upper end surface of the sample reaction plate (1), and the release channel (11) is connected to the bottom of the groove (6); the release mechanism (2) comprises a squeezing plate (22) arranged above the sample reaction plate (1) and a second driving device for driving the squeezing plate (22) to move up and down, and a squeezing block (23) that can fit with the groove (6) is convexly provided at the bottom of the squeezing plate (22).

7. The automatic reagent release device according to claim 6, characterized in that: The shape of the extrusion block (23) is hemispherical.

8. The automatic reagent release device according to claim 1, characterized in that: The capsule chamber is a groove (6) arranged on the sample reaction plate (1), the opening of the groove (6) is parallel to the upper end surface of the sample reaction plate (1), the release channel (11) is connected to the bottom of the groove (6) and is provided with an inclination, and a steel ball (7) is sealed between the groove (6) and the release channel (11); the aluminum foil strip (4) is provided with an air vent (41) at the center position of the opening of the groove (6); the release mechanism (2) can make the steel ball (7) fall into the release channel (11).

9. The automatic reagent release device according to claim 8, characterized in that: The steel ball (7) is wax-sealed between the groove (6) and the release channel (11), and the release mechanism (2) is a heating device for heating the steel ball (7).

10. The automatic reagent release device according to claim 1, characterized in that: The material of the capsule is one or more of polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polypropylene, polyvinyl chloride, ABS, thermoplastic polyurethane elastomer rubber, polystyrene, polysulfone, and transparent nylon.

Images