Additive applied to pregnant sows, application, sow feed and medicine

Abstract

The invention belongs to the field of breeding, and discloses an additive applied to pregnant sows, which comprises 25-hydroxyvitamin D3 and daidzein. According to the compound feed disclosed by the invention, the 25-hydroxyvitamin D3 and the soybean flavone are compounded for use, so that the litter size and the live litter size of the sow can be effectively increased; meanwhile, the invention also discloses application of the additive, a sow feed and a medicine.

Description

Technical Field

[0001] The invention relates to the field of breeding, and in particular to an additive applied to pregnant sows, uses, sow feed and medicine. Background Art

[0002] 25-Hydroxyvitamin D 3 It can effectively improve the health of sows and piglets. The specific technical solutions are as follows:

[0003] CN112956601A 25-hydroxyvitamin D 3 Application in improving piglet quality;

[0004] CN111789192A A functional additive for improving the reproductive performance of breeding pigs and a preparation method thereof;

[0005] CN109820092A A feed additive for increasing the bone strength of sows and improving the reproductive performance of sows.

[0006] In the preliminary experiments of this project, sows were fed 25-hydroxyvitamin D 3 It can increase the litter size from 13.57 to 13.86 and the number of live piglets from 12.36 to 13.07.

[0007] To further enhance the above performance, increase 25-hydroxyvitamin D 3 The purpose cannot be achieved.

[0008] The technical problem solved in this case is: how to further increase the number of piglets born and the number of piglets born alive by sows. Summary of the invention

[0009] The purpose of the present invention is to provide an additive for pregnant sows, which uses 25-hydroxyvitamin D 3 3. The compound use of soybean flavonoids can effectively increase the number of piglets born and the number of piglets born alive;

[0010] At the same time, the invention also discloses the application of the additive, sow feed and medicine.

[0011] The specific scheme of the present invention is:

[0012] A supplement for pregnant sows, comprising 25-hydroxyvitamin D 3 , soybean flavonoids;

[0013] 25-Hydroxyvitamin D 3 , the weight ratio of soybean flavonoids is 1:500~1:2000.

[0014] The present invention uses 25-hydroxyvitamin D3 , soybean flavonoids, can increase the litter size of sows from 13.50 to 14.78, and the litter size from 12.56 to 13.89, which is significantly better than using 25-hydroxyvitamin D alone 3 situation.

[0015] 25-hydroxyvitamin D 3 Single use, 25-hydroxyvitamin D 3 It has a variety of effects, which can not only improve the reproductive performance of sows and the survival performance of piglets, but also improve the bone health of pigs.

[0016] Soybean flavonoids are flavonoid compounds, a type of secondary metabolite formed during soybean growth, and a biologically active substance. Because they are extracted from plants and have a similar structure to estrogen, soybean flavonoids are also called phytoestrogens. The estrogenic effect of soybean flavonoids affects hormone secretion, metabolic biological activity, protein synthesis, and growth factor activity;

[0017] Some reports indicate that soybean flavonoids have the function of promoting estrus in sows, such as CN107410724A, a mixed feed additive for promoting estrus in sows and a method of using the same;

[0018] There are relatively few literatures on the efficacy of soy flavonoids in promoting litter size. In preliminary experiments, we found that when soy flavonoids were used, the litter size increased from 13.31 to 13.38, and the number of piglets born alive increased from 12.23 to 12.54. There was no significant difference in either the litter size or the number of piglets born alive.

[0019] Therefore, the present application believes that soybean flavonoids can increase the estrus rate of sows, but have little contribution to reproductive performance, especially to reproductive performance of sows.

[0020] The present invention can increase the litter size and the number of live piglets by mixing the above two substances. We speculate that the reason for this effect is that:

[0021] (1) The combined use of the two has a synergistic effect: ① Endocrine regulation: 25-hydroxyvitamin D 3 It can improve the reproductive performance of sows and the survival performance of piglets, while soybean flavonoids have an effect similar to estrogen and can affect hormone secretion and metabolism. The two may optimize the endocrine state of sows through synergistic effects, thereby increasing the ovulation rate and pregnancy rate. ② Hormone balance: 25-hydroxyvitamin D 3 It is beneficial to bone health and the immune system, while soybean flavonoids can promote estrus in sows. The combined effect of the two may regulate the balance of estrogen and progesterone in sows, thereby improving reproductive efficiency.

[0022] (2) The combined use of the two has nutritional complementarity: 25-hydroxyvitamin D 3 Each of them provides specific nutrients and bioactive substances. When used together, they can provide more comprehensive nutritional support, enhance the overall health of sows, and thus promote their reproductive performance. In addition, 25-hydroxyvitamin D 3 It may promote the development of bones and other tissues, while soy flavonoids can affect protein synthesis and growth factor activity. This complementary mechanism of action may improve the health of sows during pregnancy and provide a better environment for fetal development.

[0023] (3) The combination of the two has antioxidant and anti-stress enhancing effects: 25-hydroxyvitamin D 3 It has an antioxidant effect and can reduce the oxidative stress of sows during pregnancy, while soybean flavonoids also have antioxidant capacity. The combined use of the two may jointly enhance the antioxidant defense system of sows and protect the reproductive system from damage.

[0024] In the above-mentioned additives, the 25-hydroxyvitamin D 3 , the weight ratio of soybean flavonoids is preferably 1:1000.

[0025] At the same time, the invention also discloses the use of the additive as described above in preparing sow feed or medicine for sows.

[0026] In the above-mentioned use, the sow feed is a feed used to increase the number of piglets born by sows and the number of piglets born alive.

[0027] In the above-mentioned use, the sow medicine is a medicine used to increase the number of piglets born and the number of piglets born alive by sows.

[0028] In addition, the present invention also discloses a sow feed, comprising a basic feed and the additive as described above added to the basic feed.

[0029] In the above-mentioned sow feed, the basic feed is added with 0.002-0.01wt% of additives.

[0030] Finally, the present invention also discloses a medicine for sows, wherein the active ingredient in the medicine is the additive as described above.

[0031] The beneficial effects of this application are:

[0032] The present invention adopts 25-hydroxyvitamin D 3 , the compound use of soybean flavonoids and adding it to sow feed can effectively increase the number of piglets born and the number of piglets born alive. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1To add 25-hydroxyvitamin D 3 Effects on sow litter size and number of piglets born alive;

[0034] Figure 2 To investigate the effect of soybean flavonoid supplementation on sow litter size and number of piglets born alive;

[0035] Figure 3 To add 25-hydroxyvitamin D 3 The effects of soybean flavonoids on the litter size and number of piglets born alive in sows. DETAILED DESCRIPTION

[0036] The present invention will be described clearly and completely below in conjunction with the embodiments of the present invention. In the description of the present invention, it should be noted that, if no specific conditions are specified in the embodiments, the conditions are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0037] Example 1

[0038] The experiment selected 28 sows of 60 days of gestation with the same parity, similar body weight and backfat thickness, and randomly divided them into two groups, respectively fed with a basic diet and a basic diet supplemented with 50 μg / kg 25-hydroxyvitamin D. 3 , 14 replicates per group, 1 sow per replicate, fed in stalls. The basic feed formulation refers to the NRC (2012) standard. The daily feeding amount is 2.5 kg / head from the 60th day to the 85th day of pregnancy, and the daily feeding amount is 3 kg / head from the 85th day of pregnancy to delivery. Feed once at 8 am and 3 pm each day. All sows will have free access to water throughout the experimental period. All sows will be transferred to the delivery room 7 days before delivery. The experimental period is 54 days from the 60th day of pregnancy to the end of delivery. The experimental design is shown in Table 1, and the results of sow reproductive performance are shown in Table 2 and Figure 1 .

[0039] Table 1 Experimental design

[0040] Treatment Group 2 Pregnant sows / pen 1 Column / Treatment Group 14 Pregnant sows / treatment group 14 Total columns 28 Total number of pregnant sows 28

[0041] Table 2 Effect of additives in this example on reproductive performance of sows

[0042] project Control group Experimental Group P-value Litter size 13.57±0.42 13.86±0.35 0.601 Number of piglets born alive 12.36±0.43 13.07±0.34 0.202 Number of stillbirths 0.64±0.31 0.64±0.20 1.000 Number of mummies produced 0.50±0.23 0.14±0.14 0.199

[0043] It can be seen from the above results that adding the additive of this example to the diet of pregnant sows can increase the litter size from 13.57 to 13.86 and the live piglets from 12.36 to 13.07, but the improvement effect is not significant.

[0044] Example 2

[0045] The experiment selected 26 long×large dual-purpose sows at 60 days of gestation with the same parity, similar body weight and backfat thickness, and randomly divided them into 2 groups. They were fed with a basic diet and a basic diet supplemented with 50 mg / kg soybean flavonoids, respectively. Each group had 13 replicates, with 1 sow in each replicate, and they were fed in stalls. The formulation of the basic diet refers to the NRC (2012) standard. The daily feeding amount from the 60th to the 85th day of gestation is 2.5 kg / head, and the daily feeding amount from the 85th day of gestation to delivery is 3 kg / head, with feeding once at 8 am and 3 pm each day. All sows will have free access to water throughout the experimental period. All sows will be transferred to the delivery room 7 days before delivery. The experimental period is 54 days from the 60th day of gestation to the end of delivery. The experimental design is shown in Table 3, and the results of sow reproductive performance are shown in Table 4 and Figure 2 .

[0046] Table 3 Experimental design

[0047] Treatment Group 2 Pregnant sows / pen 1 Column / Treatment Group 13 Pregnant sows / treatment group 13 Total columns 26 Total number of pregnant sows 26

[0048] Table 4 Effect of the additives in this example on sow reproductive performance

[0049]

[0050]

[0051] It can be seen from the above results that adding the additive of this example to the diet of pregnant sows can increase the litter size from 13.31 to 13.38 and the live piglets from 12.23 to 12.54, but the improvement effect is not significant.

[0052] Example 3

[0053] Thirty-six sows of the same parity, similar body weight and backfat thickness at 60 days of gestation were randomly divided into two groups and fed with a basic diet or a basic diet supplemented with 50 μg / kg 25-hydroxyvitamin D. 3 and 50mg / kg soybean flavonoids, 18 replicates per group, 1 sow per replicate, fed in stalls. The basic feed formulation refers to the NRC (2012) standard. The daily feeding amount is 2.5kg / head from the 60th to the 85th day of pregnancy, and the daily feeding amount is 3kg / head from the 85th day of pregnancy to delivery, feeding once at 8 am and 3 pm each day. All sows will have free access to water throughout the experimental period. All sows will be transferred to the delivery room 7 days before delivery. The experimental period is 54 days from the 60th day of pregnancy to the end of delivery. The experimental design is shown in Table 5, and the results of sow reproductive performance are shown in Table 6 and Figure 3 .

[0054] Table 5 Experimental design

[0055] Treatment Group 2 Pregnant sows / pen 1 Column / Treatment Group 18 Pregnant sows / treatment group 18 Total columns 36 Total number of pregnant sows 36

[0056] Table 6 Effect of the additives prepared in this example on the reproductive performance of sows

[0057] project Control group Experimental Group P-value Litter size 13.50±0.61 14.78±0.37 0.084 Number of piglets born alive 12.56±0.48 13.89±0.34 0.031 Number of stillbirths 0.56±0.20 0.56±0.23 1.000 Number of mummies produced 0.39±0.29 0.33±0.16 0.869

[0058] It can be seen from the above results that adding the additive prepared in this embodiment to the diet of pregnant sows can increase the litter size from 13.50 to 14.78, an increase of 9.48%; the live piglets can be increased from 12.56 to 13.89, an increase of 10.59%, and the improvement effect is obvious.

[0059] Result analysis:

[0060] It can be seen from the above examples 1 to 3 that the use of 25-hydroxyvitamin D alone 3 , soybean flavonoids, which had no advantages over the control group in terms of litter size and live piglets, but after the two were used in combination, they showed a significant improvement effect, indicating that the composition of the present invention can be used as a sow feed additive to increase the litter size and live piglets.

Claims

1. An additive for pregnant sows, characterized in that: Including 25-hydroxyvitamin D3, soy flavonoids; The weight ratio of the 25-hydroxyvitamin D3 to soybean flavonoids is 1:500 to 1:2000.

2. The additive according to claim 1, characterized in that The weight ratio of the 25-hydroxyvitamin D3 to soybean flavonoids is preferably 1:1000.

3. Use of the additive as claimed in claim 1 or 2 in preparing sow feed or medicine for sows.

4. The use according to claim 3, characterized in that The sow feed is a feed used for increasing the number of piglets born by sows and the number of piglets born alive.

5. The use according to claim 3, characterized in that: The sow medicine is a medicine used for increasing the number of piglets born and the number of piglets born alive by sows.

6. A sow feed, characterized in that: The method comprises a basic feed and the additive according to claim 1 or 2 added to the basic feed.

7. The sow feed according to claim 6, characterized in that The basic feed is added with 0.002-0.01wt% of additives.

8. A medicine for sows, characterized in that: The active ingredient in the medicine is the additive as claimed in claim 1 or 2.

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