Amomum villosum processing method

Abstract

The invention provides a processing method of Amomum villosum and belongs to the technical field of traditional Chinese medicinal material processing. The processing method comprises three times of drying (including one time of fixation) and two times of cooling. Compared with a traditional processing method, the processing method disclosed by the invention has the advantages that the processing process is easy to control, the workshop-style traditional production place primary processing technology of peasant households is improved, the processing efficiency of the Amomum villosum is doubled, the processing time of the Amomum villosum is greatly shortened, the time and the labor cost can be saved, and the production cost of the Amomum villosum is reduced. The processing efficiency of the production place is improved, the loss of effective components is reduced, the stable quality of the Amomum villosum is ensured, and the method is suitable for large-scale production of the Amomum villosum. The contents of water, volatile oil and bornyl acetate in the amomum villosum obtained by the processing method all meet pharmacopeia standards.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicinal material processing, in particular to a method for processing Amomum villosum. Background Art

[0002] Amomum villosum Lour., also known as spring Amomum, is derived from the dried mature fruit of the ginger plant Amomum villosum Lour. It is pungent and warm in nature; it enters the spleen, stomach, and kidney meridians. It has the effects of removing dampness and appetizing, warming the spleen and stopping diarrhea, regulating qi and calming the fetus. It is mainly used for dampness and turbidity blocking the middle, abdominal distension without hunger, spleen and stomach deficiency and cold, vomiting and diarrhea, nausea during pregnancy, and restless fetus. Amomum villosum is native to Yangchun, Guangdong and surrounding areas, and was later introduced to Guangxi, Yunnan, Fujian and other places. The one produced in Yangchun is the best.

[0003] Amomum villosum is a local medicinal material in Guangdong and one of the famous "four major southern medicines" in my country. The main active ingredient of Amomum villosum is its volatile oil, which has the pharmacological effects of gastrointestinal protection, antibacterial, anti-inflammatory and analgesia, and can also be used to treat many digestive system diseases. Improper processing methods will cause its effective ingredients to volatilize, reduce or lose its efficacy. Through field research, it was found that the traditional processing method of Amomum villosum in Naruan Village, Heshui Town, Yangchun City, Guangdong Province, the authentic production area of ​​Amomum villosum, is to heat with firewood, kill for a long time, and then alternately dry and put it in a suffocating state until it is dry. The Amomum villosum fruits processed by local farmers in Yangchun have good sealing properties, the shell is not easy to burst, the seed group is compact, the dryness is good, it is easy to preserve, not easy to mold and insects, and the storage time is long and the quality is good. However, its obvious disadvantages are that the processing operation is not standardized, the temperature is difficult to control, and the main active ingredient volatile oil of Amomum villosum is easy to lose, resulting in unstable quality; at the same time, the long-term killing and suffocating state generally requires a processing cycle of about one week, and during the drying period, it is necessary to manually heat the charcoal fire and turn the Amomum villosum many times, which increases the labor cost.

[0004] Therefore, how to retain the volatile oil content of Amomum villosum to the maximum extent during the processing, and provide a convenient and time-saving Amomum villosum processing method, which has the same appearance and internal quality as the products processed by traditional processing methods and minimizes the loss of volatile oil, is an urgent problem that needs to be solved at present. Summary of the invention

[0005] The invention aims to overcome the shortcomings of the prior art and provide a method for processing Amomum villosum, which greatly improves the processing efficiency of Amomum villosum, is simple and controllable to operate, ensures the stable quality of Amomum villosum, and is suitable for large-scale production of Amomum villosum.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] In a first aspect, the present invention provides a method for processing Amomum villosum, comprising the steps of: fixing and drying clean Amomum villosum, and then cooling and drying twice to obtain processed Amomum villosum; during the cooling and drying process, a four-layer structure of linen-Amomum villosum-linen-airtight film is used for cooling, and the drying conditions are as follows: a drying temperature of above 60°C and a drying time of more than 4 hours.

[0008] Traditional Amomum villosum processing method is time-consuming and has low efficiency (about 122h). The present invention, through a large number of experiments, explores a temperature-controlled, simple and time-saving Amomum villosum processing method. The processing method only needs 61h to process Amomum villosum, and the Amomum villosum seed group processed is compact, dryness is good, easy to preserve, and volatile oil content is high, and quality is high, which meets the standard of pharmacopoeia. The processing method of the present invention adopts cloth cooling Amomum villosum, absorbs moisture, and is convenient to subsequent drying. The present invention finds through a large number of experiments that in the Amomum villosum processing process, the temperature and time of drying are very critical for controlling the quality of Amomum villosum, and it is necessary to reach the drying temperature and time provided by the present invention, so as to obtain moderate moisture, Amomum villosum with high volatile oil and borneol acetate content.

[0009] Preferably, the processing method specifically comprises the following steps:

[0010] (1) washing and draining the Amomum villosum and spreading it out for fixing, i.e., the first drying process;

[0011] (2) first cooling: first lay a layer of airtight film, then lay a layer of linen, pile the fixed Yangchun sand obtained in step (1) on the linen, cover the Yangchun sand with a layer of linen and let it cool;

[0012] (3) drying for the second time: spreading the cooled Amomum villosum obtained in step (3) and drying it;

[0013] (4) Second cooling: repeat step (2) to perform second cooling;

[0014] (5) drying for the third time: repeating the step (3) to perform drying for the third time; after drying, cooling to obtain processed Amomum villosum.

[0015] Preferably, in step (1), the conditions for fixing are: drying temperature 65° C., and drying time 3 hours.

[0016] Preferably, in step (2), the stacking thickness is 5-6 cm and the cooling time is 16-30 hours.

[0017] Preferably, in steps (3) and (5), the drying conditions are: the drying temperature is above 60° C. and the drying time is greater than 4 hours.

[0018] Preferably, in steps (3) and (5), the drying conditions are: drying temperature 60°C-65°C, and drying time 4h-6h.

[0019] Preferably, in steps (3) and (5), the drying conditions are: drying temperature 60° C., and drying time 6 h.

[0020] Preferably, in step (4), the stacking thickness is 5-6 cm and the cooling time is 16 hours.

[0021] Preferably, in the step (5), after drying, the Amomum villosum is placed in a plastic sealed bag for storage.

[0022] The preliminary standard for measuring whether the Yangchun sand is dried is that there is no water vapor generated on the wall of the plastic sealed bag on the second day after storage.

[0023] In a second aspect, the present invention provides Yangchun Agarwood obtained by the Yangchun Agarwood processing method.

[0024] Preferably, the Amomum villosum satisfies the following quality standards: moisture content ≤ 15.0%, volatile oil content ≥ 3.0% (mL / g), and bornyl acetate content ≥ 0.90%.

[0025] The present invention is beneficial in that:

[0026] The traditional processing method is to fix the green for dozens of hours, stack and moisten for several days, and repeatedly dry and dry until dry. The processing time of this method is long, and the heating method of the drying room used for traditional drying is still charcoal heating, and the temperature is difficult to control. The Yangchun sand processing method provided by the present invention improves the traditional primary processing technology of the production area of ​​the farmer's workshop, and promotes the current scattered and single-family processing method to a large-scale processing method, so that the processing efficiency of Yangchun sand is increased by 1 times.

[0027] Compared with the traditional processing method, the processing method of the present invention is different in that: first, the heating method is different. The traditional processing method adopts charcoal fire heating, the temperature is uncontrollable, the environmental pollution is large and manual control of the temperature is required, while the processing method of the present invention adopts electric heating, which is more environmentally friendly and the temperature is controllable; second, the cooling method is different. The traditional processing method adopts woven bags to moisten the Yangchun sand, while the processing method of the present invention adopts cloth to cool the Yangchun sand, and the cloth can absorb the moisture of the Yangchun sand, which is convenient for subsequent drying.

[0028] The processing method of the invention is simple and easy to operate; the processed Amomum villosum seeds are compact, have good dryness, are easy to preserve, have high volatile oil content, are of high quality, and the processing cycle is significantly shortened.

[0029] The processing method of the invention is stable and controllable, can retain the volatile oil of the effective component of Amomum villosum to a greater extent, can be promoted and applied, and has good prospects.

[0030] In summary, the processing method of the present invention is not only simple and feasible, and can obtain high-quality Yangchun sand, but also improves the traditional farmer-workshop-style primary processing technology of the production site. Compared with the processing time required by the traditional processing technology, the processing time required by the method of the present invention is only half of that of the traditional processing method, which greatly shortens the processing time of Yangchun sand, and the capacity of the machine is larger than the traditional processing volume, so that the daily processing volume of Yangchun sand is increased by more than 3 times, which significantly shortens the processing time. It can be promoted and applied, and has a good prospect. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a plastic screen, drying rack and drying room used for drying Amomum villosum.

[0032] Figure 2 It is the stacking thickness of Yangchun sand.

[0033] Figure 3 It is the Amomum villosum obtained by the processing method of the present invention. DETAILED DESCRIPTION

[0034] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0035] The Amomum villosum raw materials used in the present invention are all Amomum villosum from Yangchun, Guangdong.

[0036] Embodiment 1:

[0037] An embodiment of the Yangchun sand processing method of the present invention; the processing method comprises the following steps:

[0038] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0039] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0040] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0041] (4) drying for the second time: spreading the cooled Amomum villosum obtained in step (3) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the second drying are: drying temperature 60° C., drying time 5 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0042] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0043] (6) drying for the third time: the cooled Amomum villosum obtained in step (5) is spread out into a layer on a plastic sieve, placed on a drying rack, and dried in a drying room. The conditions for the third drying are: drying temperature 60° C., drying time 5 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0044] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0045] Embodiment 2:

[0046] An embodiment of the Yangchun sand processing method of the present invention; the processing method comprises the following steps:

[0047] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0048] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0049] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0050] (4) drying for the second time: the cooled Amomum villosum obtained in step (3) is spread out into a layer on a plastic sieve, placed on a drying rack, and dried in a drying room. The conditions for the second drying are: drying temperature 65° C., drying time 3 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0051] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0052] (6) drying for the third time: spreading the cooled Amomum villosum obtained in step (5) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the third drying are: drying temperature 65° C., drying time 3 hours; turning the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0053] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0054] Embodiment 3:

[0055] An embodiment of the Yangchun sand processing method of the present invention; the processing method comprises the following steps:

[0056] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0057] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0058] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0059] (4) drying for the second time: the cooled Amomum villosum obtained in step (3) is spread out into a layer on a plastic sieve, placed on a drying rack, and dried in a drying room. The conditions for the second drying are: drying temperature 65° C., drying time 5 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0060] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0061] (6) drying for the third time: the cooled Amomum villosum obtained in step (5) is spread out into a layer on a plastic sieve, placed on a drying rack, and dried in a drying room. The conditions for the third drying are: drying temperature 65° C., drying time 5 hours; turning the Amomum villosum once during the drying process to ensure uniform heating;

[0062] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0063] Embodiment 4:

[0064] An embodiment of the Yangchun sand processing method of the present invention; the processing method comprises the following steps:

[0065] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0066] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0067] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0068] (4) drying for the second time: the cooled Amomum villosum obtained in step (3) is spread out into a layer on a plastic sieve, placed on a drying rack, and dried in a drying room. The conditions for the second drying are: drying temperature 60° C., drying time 6 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0069] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0070] (6) drying for the third time: the cooled Amomum villosum obtained in step (5) is spread out into a layer on a plastic sieve, placed on a drying rack, and dried in a drying room. The conditions for the third drying are: drying temperature 60° C., drying time 6 hours; turning the Amomum villosum once during the drying process to ensure uniform heating;

[0071] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0072] Comparative Example 1:

[0073] A comparative example of the processing method of Amomum villosum of the present invention; the processing method comprises the following steps:

[0074] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0075] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0076] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0077] (4) drying for the second time: spreading the cooled Amomum villosum obtained in step (3) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the second drying are: a drying temperature of 50° C. and a drying time of 3 hours; turning the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0078] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0079] (6) drying for the third time: spreading the cooled Amomum villosum obtained in step (5) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the third drying are: drying temperature 50° C., drying time 3 hours; turning the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0080] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0081] Comparative Example 2:

[0082] A comparative example of the processing method of Amomum villosum of the present invention; the processing method comprises the following steps:

[0083] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0084] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0085] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0086] (4) drying for the second time: spreading the cooled Amomum villosum obtained in step (3) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the second drying are: a drying temperature of 50° C. and a drying time of 5 hours; turning the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0087] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0088] (6) drying for the third time: spreading the cooled Amomum villosum obtained in step (5) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the third drying are: drying temperature 50° C., drying time 5 hours; turning the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0089] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0090] Comparative Example 3:

[0091] A comparative example of the processing method of Amomum villosum of the present invention; the processing method comprises the following steps:

[0092] (1) Cleaning and draining: Pick fresh Amomum villosum, remove the fruit stalks and rotten fruits, wash away the mud and sand, and dry them until no water drops;

[0093] (2) Fixing (first drying): Spread the washed and drained Amomum villosum on a plastic sieve into a layer, place on a drying rack, and push into a drying room for drying. The conditions for fixing (first drying) are: drying temperature 65° C., drying time 3 hours; turn the Amomum villosum once during the drying process to ensure that it is evenly heated;

[0094] (3) first cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the fixed Yangchun sand obtained in step (2) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Yangchun sand with a layer of linen to cool it, and the cooling time is 16-30 hours;

[0095] (4) drying for the second time: spreading the cooled Amomum villosum obtained in step (3) on a plastic sieve into a layer, placing it on a drying rack, and drying it in a drying room. The conditions for the second drying are: drying temperature 60° C., drying time 4 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0096] (5) second cooling: first lay a layer of airtight plastic film, then lay a layer of linen, take out the dried Amomum villosum obtained in step (4) from the drying room and pile it on the linen, the pile thickness is 5-6 cm, and cover the piled Amomum villosum with a layer of linen and let it cool for 16 hours;

[0097] (6) drying for the third time: the cooled Amomum villosum obtained in step (5) is spread out on a plastic sieve into a layer, placed on a drying rack, and dried in a drying room. The conditions for the third drying are: drying temperature 60° C., drying time 4 hours; turning the Amomum villosum once during the drying process to ensure that it is heated evenly;

[0098] (7) Storage: After the three drying steps are completed and the temperature drops to about 50°C, pack the mixture in a sealed plastic bag and store it in a dry and cool place.

[0099] Test Example 1: Determination of volatile oil and water content in Amomum villosum

[0100] Test sample: Amomum villosum obtained by the processing methods described in Examples 1-4 and Comparative Examples 1-3.

[0101] Determination of volatile oil content in Amomum villosum:

[0102] According to the volatile oil extraction method A in the 2020 edition of the "Chinese Pharmacopoeia", 15 g of Amomum villosum seed mass was accurately weighed, crushed for 10 seconds and let stand, crushed for 5 seconds and let stand, and finally crushed for 5 seconds, weighed, placed in a 1000mL round-bottom flask, added 500mL of water, shaken to mix, connected the volatile oil analyzer and the reflux condenser, soaked for 2 hours, heated and maintained at a slight boiling for about 5 hours until the volatile oil content no longer increased, let stand, read according to method A, record, collect the volatile oil, collect in 1.5mL centrifuge tubes, store at 4℃ for later use, and measure 2 copies of each sample in parallel.

[0103] Determination of moisture content in Amomum villosum: Use HE53 halogen moisture analyzer, and each sample is measured in triplicate.

[0104] The results of the determination of volatile oil content are shown in Table 1, and the results of the determination of water content are shown in Table 2.

[0105] Table 1 Volatile oil content determination results

[0106]

[0107]

[0108] Table 2 Moisture content measurement results (powder weight 1.000g)

[0109]

[0110]

[0111] Table 3 below is a comparison of the differences in moisture and volatile oil content caused by the temperature and time of secondary drying and tertiary drying in the processing methods described in each embodiment and comparative example:

[0112] Table 3 Determination results of moisture and volatile oil content of Amomum villosum obtained from Examples 1-4 and Comparative Examples 1-3

[0113]

[0114] Note: The quality standard of Amomum villosum stipulated in the 2020 edition of the Chinese Pharmacopoeia is: the moisture content shall not exceed 15.0%, and the volatile oil content of Amomum villosum seed mass shall not be less than 3.0% (mL / g).

[0115] The results show that the drying temperature in the processing method of Amomum villosum is 60°C or below. Only when the drying temperature reaches 60°C and the drying time is controlled to be not less than 5h, the moisture and volatile oil content in the Amomum villosum obtained by Example 1 meet the quality standards of the 2020 edition of the Chinese Pharmacopoeia; while at least one of the moisture and volatile oil content in the Amomum villosum obtained by Comparative Examples 1-3 does not meet the requirements of the quality standards of the 2020 edition of the Chinese Pharmacopoeia. Among them, the moisture content in the Amomum villosum obtained by the processing methods described in Comparative Examples 1, 2 and 3 does not meet the quality standards of the 2020 edition of the Chinese Pharmacopoeia; the volatile oil content in the Amomum villosum obtained by the processing method described in Comparative Example 1 is also not up to standard.

[0116] When the drying temperature in the processing method of Amomum villosum is higher than 60°C, the moisture and volatile oil contents in the Amomum villosum obtained by Examples 1-4 meet the requirements of the quality standards of the 2020 edition of the Chinese Pharmacopoeia.

[0117] This shows that in the processing method of Amomum villosum, by controlling the drying temperature at 60°C or above and the drying time for more than 4 hours, the moisture content of the processed Amomum villosum can meet the quality standards; with the increase of drying temperature and the extension of time, the volatile oil content of the processed Amomum villosum shows a gradually decreasing trend.

[0118] Compared with other embodiments, in the processing method described in Example 4, 60°C is used as the temperature for the second drying and third drying of the Amomum villosum, and 6 hours is used as the time for the second drying and third drying of the Amomum villosum. The obtained Amomum villosum volatile oil content meets the pharmacopoeia standard and is the highest, which can reduce the loss of the effective ingredients of the Amomum villosum to a greater extent, and is the best processing condition.

[0119] Since the whole process is carried out in a temperature-controllable drying room, the heat is evenly applied, so that the product quality is uniform. The moisture content and the volatile oil content in the Amomum villosum obtained by the processing method of Example 4 of the present invention are in line with the pharmacopoeia standards, and the content of the volatile oil is retained to a greater extent.

[0120] Test Example 2: Determination of Bornyl Acetate Content in Amomum villosum

[0121] Test sample: Amomum villosum obtained by the processing method described in Examples 1-4.

[0122] Bornyl acetate content determination method:

[0123] Chromatographic conditions: Agilent HP-5MS capillary column (30m×250μm, 25μm); carrier gas is high-purity helium, column temperature is 100℃ for 18min, injection port temperature is 230℃, detector (FID) temperature is 250℃; split ratio is 10:1. The theoretical plate number calculated based on the bornyl acetate peak should not be less than 10,000.

[0124] Preparation of reference solution: Take an appropriate amount of borneol acetate reference substance, accurately weigh it, add anhydrous ethanol (chromatographic grade) to make a mother solution containing 1.5 mg per 1 mL, and dilute it to a solution containing 0.3 mg per 1 mL.

[0125] Preparation of test solution: Take about 1 g of sample powder (passed through No. 3 sieve), accurately weigh, place in a stoppered conical flask, accurately add 25 mL of anhydrous ethanol, stopper, weigh, ultrasonically treat for 30 minutes, cool, make up the lost weight with anhydrous ethanol, shake well, filter, and take the filtrate to obtain. Each sample should be measured in parallel in 2 portions.

[0126] Determination method: Accurately pipette 1 μL of the reference solution and the test solution respectively, inject into the gas chromatograph, measure, record the peak area, calculate the content of bornyl acetate by the peak area, measure each sample twice, and the RSD value of the two parallel samples is <2%.

[0127] The content of bornyl acetate in each sample was calculated according to the following formula:

[0128]

[0129] The results of determination of bornyl acetate content in Amomum villosum are shown in Table 4.

[0130] Table 4 Bornyl acetate content determination results in Amomum villosum obtained from Example 1-4

[0131]

[0132]

[0133] Note: The 2020 edition of the Chinese Pharmacopoeia stipulates that the moisture content shall not exceed 15.0%, and the volatile oil content of Amomum villosum seed mass shall not be less than 3.0% (mL / g). This product, calculated on a dry basis, contains borneol acetate (C 12 H 20 O2) shall not be less than 0.90%.

[0134] The results show that the content of bornyl acetate in the Amomum villosum seed mass processed in the examples of the present invention meets the pharmacopoeia standards.

[0135] The present invention finds through field research that the traditional processing method of Amomum villosum in Naruan Village, Heshui Town, Yangchun City, Guangdong Province, the authentic production area of ​​Amomum villosum, is nearly half the time (about 122h) more than the processing method described in the embodiment of the present invention (about 61h). From the perspective of finished product quality, because the whole process of processing is in a temperature-controlled drying room, it is evenly heated, so that the product quality is uniform, the moisture content, volatile oil content, and borneol acetate content in the Amomum villosum obtained by the inventive method all meet the pharmacopoeia standard, and the loss of the effective ingredient of Amomum villosum can be effectively reduced.

[0136] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A method for processing Yangchun sand, characterized in that: After the clean Amomum villosum is withered and dried, it is cooled and dried twice to obtain processed Amomum villosum; during the cooling and drying process, a four-layer structure of linen-Amomum villosum-linen-airtight film is used for cooling, and the drying conditions are: the drying temperature is above 60°C and the drying time is greater than 4 hours.

2. The method for processing Yangchun sand according to claim 1, characterized in that: The processing method specifically comprises the following steps: (1) washing and draining the Amomum villosum and spreading it out for fixing, i.e., the first drying process; (2) first cooling: first lay a layer of airtight film, then lay a layer of linen, pile the fixed Yangchun sand obtained in step (1) on the linen, cover the Yangchun sand with a layer of linen and let it cool; (3) drying for the second time: spreading the cooled Amomum villosum obtained in step (3) and drying it; (4) Second cooling: repeat step (2) to perform second cooling; (5) drying for the third time: repeating the step (3) to perform drying for the third time; after drying, cooling to obtain processed Amomum villosum.

3. The method for processing Yangchun sand as claimed in claim 2, characterized in that: In the step (1), the conditions for fixing are: drying temperature 65° C., and drying time 3 hours.

4. The method for processing Yangchun sand as claimed in claim 2, characterized in that: In the step (2), the stacking thickness is 5-6 cm and the cooling time is 16-30 hours.

5. The method for processing Yangchun sand as claimed in claim 2, characterized in that: In the steps (3) and (5), the drying conditions are: the drying temperature is above 60° C. and the drying time is greater than 4 hours.

6. The method for processing Yangchun sand according to claim 5, characterized in that: In the steps (3) and (5), the drying conditions are: drying temperature 60° C.-65° C., and drying time 4 h-6 h.

7. The method for processing Yangchun sand according to claim 6, characterized in that: In the steps (3) and (5), the drying conditions are: drying temperature 60° C., and drying time 6 h.

8. The method for processing Yangchun sand as claimed in claim 2, characterized in that: In the step (4), the stacking thickness is 5-6 cm and the cooling time is 16 hours.

9. The Amomum villosum obtained by the Amomum villosum processing method as claimed in any one of claims 1 to 8.

10. The Amomum villosum processed by the Amomum villosum processing method according to claim 9 is characterized in that: The Amomum villosum satisfies the following quality standards: moisture content ≤15.0%, volatile oil content ≥3.0% (mL / g), and bornyl acetate content ≥0.90%.

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