Traditional Chinese medicine composition for clearing away heat and toxic materials and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for clearing away heat and toxic materials and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-16 parts of lysimachia christinae hance, 6-10 parts of plantain herb, 6-10 parts of dianthus superbus, 6-10 parts of hairyvein agrimony, 6-10 parts of polygonum aviculare, 6-10 parts of talc, 3-8 parts of lygodium japonicum, 3-8 parts of fried fructus gardeniae, 6-10 parts of pericarpium citri reticulatae and 6-10 parts of liquorice tablets. Comprising the following steps: S1, weighing the raw materials according to corresponding parts by weight; s2, grinding the raw materials into powder, and drying at the temperature of 80 DEG C to obtain the traditional Chinese medicine composition. Based on the combination of disease differentiation and syndrome differentiation for treating diseases caused by downward flow of damp-heat in traditional Chinese medicine, the lysimachia christinae hance and the lygodium japonicum in the formula are used for inducing diuresis and treating stranguria and are combined to serve as essential medicines for treating stranguria and astringent pain; talc, fringed pink and polygonum aviculare clear bladder heat accumulation, promote urination and induce diuresis for treating stranguria; plantain herb can clear away heat and toxic materials and induce diuresis; the fried cape jasmine has the effects of purging fire evil of three-jiao, clearing away the heart-fire and relieving The hairyvein agrimony astringes to stop bleeding and can be used for both cold and heat Pericarpium citri reticulatae strengthens spleen and harmonizes middle warmer; and licorice can regulate drug properties. The ten medicines have the effects of clearing away heat and toxic materials, inducing diuresis for treating stranguria, strengthening the spleen and regulating the middle warmer, and particularly have a peculiar effect on heat stranguria and astringent pain.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for clearing away heat and detoxifying and a preparation method thereof. Background Art

[0002] Damp-heat descending is a term in traditional Chinese medicine. According to traditional Chinese medicine, the bladder is the home of body fluids. Damp-heat accumulates in the lower part of the body and descends to the bladder. Damp-heat blocks the kidney and bladder, causing abnormal gasification of the kidney and bladder. This causes poor urination, painful and astringent urine, red urine, turbid urine, frequent urination, and poor urination (i.e., frequent urination, urgent urination, short urination, painful urination, etc.). Damp-heat descending mainly manifests as short and red urine, heavy body and fatigue, yellow and greasy tongue coating, and weak and rapid pulse. Symptoms include astringent and red painful urination, lower abdominal cramps, distending pain in the perineum, turbid white urine at the urethral opening, yellow and greasy tongue coating, and slippery and rapid pulse. Clinically, it is often seen in damp-heat dysentery, damp-heat diarrhea, turbid stranguria, urinary retention, vaginal itching, leucorrhea, lower limb joint swelling and pain, and wet athlete's foot infection.

[0003] With the continuous development of Chinese medicine in my country, people have gradually realized the advantages of Chinese medicine in treating damp-heat syndrome, and the advantages of low toxicity and side effects and low cost in the treatment process. So, how to find a Chinese medicine composition that can effectively treat the symptoms caused by damp-heat syndrome is an urgent problem that we need to solve. Summary of the invention

[0004] The purpose of the present invention is to provide a heat-clearing and detoxifying Chinese medicine composition and a preparation method thereof, aiming at the problem that the existing Chinese medicine formula has poor effect on the symptoms caused by damp-heat.

[0005] A traditional Chinese medicine composition for clearing away heat and detoxifying comprises the following raw materials in weight proportion: 12-16 parts of Lysimachia chinensis, 6-10 parts of Plantago asiatica, 6-10 parts of Dianthus superbus, 6-10 parts of Agrimoniae, 6-10 parts of Polygonum multiflorum, 6-10 parts of Talc, 3-8 parts of Lygodium japonicum, 3-8 parts of stir-fried Gardenia jasminoides, 6-10 parts of dried tangerine peel and 6-10 parts of liquorice tablets.

[0006] Further, the raw materials are composed of the following weight ratio: 15 parts of Herba Lysimachiae, 9 parts of Herba Plantaine, 9 parts of Herba Dianthus, 9 parts of Herba Agrimoniae, 9 parts of Herba Polygoni Multiflori, 9 parts of Talc, 6 parts of Herba Lygodii, 6 parts of Fried Gardenia Jasminoides, 9 parts of Tangerine Peel, and 6 parts of Licorice Tablets.

[0007] Furthermore, the composition is a preparation prepared with raw medicinal powder as the active ingredient.

[0008] Furthermore, the preparation is an oral preparation.

[0009] Furthermore, the oral preparation is a water extract or a granule.

[0010] Centella asiatica has the effects of removing dampness and jaundice, promoting diuresis and relieving stranguria, detoxifying and reducing swelling. It is often used for damp-heat jaundice, gallbladder distension and flank pain, stranguria with stones, stranguria with heat, painful urination, carbuncle, furuncle, snake and insect bites.

[0011] Plantain, Plantain is used for painful stranguria caused by heat, edema and oliguria, diarrhea caused by summer heat and dampness, cough caused by phlegm and heat, vomiting blood, epistaxis, carbuncles and sores.

[0012] Superbus superbus, a traditional Chinese medicine, contains alkaloids, phosphoric acid, vitamin A, etc. Its flowers contain eugenol, phenylethyl alcohol, benzyl benzoate, methyl salicylate, benzyl salicylate, etc. The whole plant contains saponins, flavonoids, anthraquinones, vitamins, etc. It has the effects of diuresis, relieving stranguria, promoting blood circulation and dredging menstruation. It is often used for hot stranguria, hematuria, stranguria with stones, urinary obstruction, painful urination, and amenorrhea.

[0013] Agrimony, Agrimony is bitter and astringent, neutral and not biased, and enters the lung, liver, and spleen meridians. It is astringent and hemostatic, and also tonifies the body, detoxifies, stops dysentery, stops malaria, kills insects, stops coughs, and fights cancer. It has a strong and reliable hemostatic effect, and is suitable for all bleeding, regardless of cold, heat, deficiency or excess, and can treat chronic diarrhea, dysentery, malaria, sores, vaginal itching, leucorrhea, and exhaustion.

[0014] This product contains flavonoids, phloroglucinol, as well as agrimony lactone and tannins. It has the effects of astringency, hemostasis, antimalarial, antidysentery, detoxification and tonic.

[0015] Polygonum multiflorum is a kind of traditional Chinese medicine, and its dried aerial parts are used as medicine. It is bitter and slightly cold in nature, and belongs to the bladder meridian. Its main effects include diuresis, stranguria, insecticide and itching. It is mainly used to treat bladder heat stranguria, short and red urine, dripping and painful urine, skin eczema, vaginal itching and leucorrhea.

[0016] Talc is a diuretic and anti-dampness agent, clears away heat and relieves summer heat, removes dampness and heals sores. It is used for hot stranguria, stranguria with stones, hot and painful urination, thirst caused by summer heat and dampness, and diarrhea caused by dampness and heat; it is used externally to treat eczema, wet sores, and prickly heat. It is used for symptoms such as difficulty in urination, dripping and painful urination, and can be used with products such as Plantago seed and Akebia; it is used for watery diarrhea caused by damp heat, and can be used together with Poria cocos, Coix seed, Plantago seed, etc.

[0017] Lygodium japonicum, Lygodium japonicum is sweet, cold and non-toxic. Indications: Clearing the small intestine, curing cold and heat, curing damp-heat swelling, urinary hot stranguria, hematuria, stone stranguria, menstrual pain, and relieving heat and toxicity. Lygodium japonicum is used to treat hot stranguria, stone stranguria, blood stranguria, oozing stranguria, and urethral pain. Modern pharmacological studies have shown that it also has the effects of lowering blood sugar and anti-oxidation.

[0018] Stir-fried Gardenia: purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and detoxifying. Used for restlessness due to fever, jaundice and red urine, painful blood in the stranguria, vomiting and bleeding due to blood heat, red and swollen eyes, and fire poison sores; external treatment for sprains and contusions. Root: purging fire and detoxifying, clearing heat and promoting diuresis, cooling blood and dispersing blood stasis. Used for infectious hepatitis, traumatic injuries, and toothache due to wind and fire.

[0019] Tangerine peel, regulates qi, regulates the middle, dries dampness, and resolves phlegm. It is used to treat chest and abdominal distension, loss of appetite, vomiting, hiccups, and cough with excessive phlegm.

[0020] Licorice tablets, licorice is mild in nature and sweet in taste. It is a traditional Chinese medicine that replenishes qi and benefits the spleen. In traditional Chinese medicine, licorice has many functions. In addition to replenishing qi and benefiting the spleen, it also has the functions of clearing away heat and detoxifying, and promoting diuresis. Licorice can relieve urgency and can also play a role in harmonizing various medicines.

[0021] A method for preparing a traditional Chinese medicine composition for clearing away heat and detoxifying comprises the following steps: S1: weighing the raw materials according to corresponding weight portions; S2: grinding the raw materials into powder, and drying at 80 degrees to obtain the powder.

[0022] The invention has the following beneficial effects: the invention combines disease differentiation and syndrome differentiation based on TCM treatment of symptoms caused by damp-heat, and uses the herbs of Lysimachia chinensis and Lygodium japonicum in the prescription to promote diuresis and relieve stranguria, and the two herbs are used together to be the key medicine for all stranguria pain; talcum powder, Dianthus superbus, and Polygonum multiflorum can clear bladder heat accumulation, promote water flow, promote diuresis and relieve stranguria; plantain can clear heat and detoxify, promote diuresis and relieve stranguria; fried Gardenia can clear triple-burner fire evil, clear the heart and relieve restlessness; Herba Agrimoniae can astringe and stop bleeding, and can be used regardless of cold or heat syndrome; dried orange peel can invigorate the spleen and harmonize the middle; and licorice can harmonize the medicinal properties. These ten herbs can clear heat and detoxify, promote diuresis and relieve stranguria, and can also invigorate the spleen and harmonize the middle, and are very effective for heat stranguria pain. DETAILED DESCRIPTION

[0023] The following describes the embodiments of the present invention by specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the following embodiments and features in the embodiments can be combined with each other without conflict.

[0024] Example 1

[0025] A traditional Chinese medicine composition for clearing away heat and detoxifying comprises the following raw materials in weight proportion: 12-16 parts of Lysimachia chinensis, 6-10 parts of Plantago asiatica, 6-10 parts of Dianthus superbus, 6-10 parts of Agrimoniae, 6-10 parts of Polygonum multiflorum, 6-10 parts of Talc, 3-8 parts of Lygodium japonicum, 3-8 parts of stir-fried Gardenia jasminoides, 6-10 parts of dried tangerine peel and 6-10 parts of liquorice tablets.

[0026] The composition is a preparation prepared from raw medicinal powder as active ingredients.

[0027] The preparation is an oral preparation.

[0028] The oral preparation is water extraction or granules.

[0029] The preparation of the Chinese medicine granules is as follows: S1: weighing the raw materials according to corresponding weight portions; S2: grinding the raw materials into powder, and drying at a temperature of 80 degrees to obtain the powder.

[0030] Example 2

[0031] This embodiment is the same as Example 1, except that: 15 parts of Herba Lysimachiae, 9 parts of Herba Plantaginis, 9 parts of Herba Dianthus Superbus, 9 parts of Herba Agrimoniae, 9 parts of Herba Polygoni Multiflori, 9 parts of Talc, 6 parts of Herba Lygodii, 6 parts of Fried Gardenia Fructus, 9 parts of Citrus Reticulatae, and 6 parts of Licorice Tablets.

[0032] The preparation of the Chinese medicine granules is as follows: S1: weighing the raw materials according to corresponding weight portions; S2: grinding the raw materials into powder, and drying at a temperature of 80 degrees to obtain the powder.

[0033] Experimental example

[0034] 1. Clinical data

[0035] 1.1 General Information

[0036] The cases were 60 patients diagnosed with damp-heat syndrome in Shuangliu District Traditional Chinese Medicine Hospital of Chengdu from June 1, 2022 to October 1, 2024. They were randomly divided into two groups of 30 cases each, namely: the experimental drug group and the control drug group. The average age of the experimental drug group was (40±3.6) years old, and the average course of disease was (2.2±0.5) years. The general clinical data such as age and course of disease of the two groups were statistically processed, P>0.05, and there was no statistically significant difference, which was comparable.

[0037] 1.2 Inclusion criteria

[0038] (1) Frequent urination means a significant increase in the frequency of urination (i.e., without drinking a lot of water, the frequency of urination exceeds that of a normal adult, 4 to 6 times during the day and 0 to 2 times at night).

[0039] (2) Burning or stabbing pain in the lower abdomen or urethra during or after urination.

[0040] (3) Urine examination: urine volume ≤17ml / h or <400ml / d, urine specific gravity is low, <1.014 or even stable at around 1.010, urine will be acidic, urine protein qualitatively + to +++, and coarse granular casts can be seen in urine sediment microscopy.

[0041] 2. Treatment methods

[0042] 2.1 Treatment drugs

[0043] The control drug group A uses Sanjin Tablets, national medicine standard Z45021645, for oral administration, 3 tablets at a time, 3 times a day, after meals. The experimental drug group uses the powder of the present invention, 3 times a day, 1 pack each time, decocted in a health pot and taken after meals, 15 days as a course of treatment, and 1-2 courses of treatment are used continuously.

[0044] 2.2 Observation indicators

[0045] (1) Clinical efficacy. Markedly effective: no coarse granular casts in urine sediment microscopy; effective: no symptoms of frequent urination, urgency, and pain during urination; urine test values ​​are normal. Ineffective: symptoms of frequent urination, urgency, and pain during urination exist; urine test values ​​are outside the normal range.

[0046] (2) Clinical symptom scores. Before treatment and 7 days after treatment, the two groups were evaluated for symptoms of frequent urination, dysuria, and renal pain using a 4-level scoring system, with each item ranging from 0 to 3 points, corresponding to none, mild, moderate, and severe. The lower the score, the milder the symptom.

[0047] 2.3 Safety Observation

[0048] Observe for adverse reactions during medication, such as gastrointestinal reactions, allergic reactions, etc. If adverse reactions occur, stop the medication immediately and withdraw from this study.

[0049] Statistical methods

[0050] SPSS 22.0 statistical software was used to analyze and process the data. When the variances were equal, the t-test or one-way analysis of variance was used to compare the differences between means. When the variances were unequal, the adjusted t-test was used to compare the differences between means. The q-test was used to compare between groups, and the difference was considered statistically significant if P < 0.05.

[0051] Treatment Outcomes

[0052] 4.1 Comparison of clinical efficacy between the two groups The total effective rate of the experimental drug group was higher than that of the control group, and the difference was statistically significant (P<0.05), as shown in Table 1.

[0053] Table 1 Comparison of clinical efficacy between the two groups (%)

[0054] Group n Significant effect efficient invalid Total Effectiveness Trial drug group 30 23(76.7) 5(16.7) 2(6.6) 93.4 Control drug group 30 13(43.3) 10(33.3) 7(23.4) 76.6 P 0.028 0.462 0.022 0.043

[0055] 4.2. Comparison of clinical symptom scores between the two groups before and after treatment After treatment, the hematuria and frequent urination symptom scores of the experimental drug group were lower than those of the control drug group, and the difference was statistically significant (P<0.05), as shown in Table 2.

[0056] Table 2 Comparison of symptom scores of frequent urination, urgency and pain during urination between the two groups (`X±S)

[0057]

[0058] 4.3 Safety Observation There was no significant difference in gastrointestinal reactions and allergic reactions between the two groups after taking the medicine (P>0.05). See Table 3.

[0059] Table 3 Comparison of safety observations between the two groups (`X±S)

[0060] Group n Gastrointestinal reactions Allergic reactions Incidence Trial drug group 30 0 0 0.00 Control drug group 30 1 0 2.21 P 0.532 0.048

[0061] Summary: The present invention is based on the combination of disease differentiation and syndrome differentiation in TCM treatment of symptoms caused by damp-heat. The herb Lysimachia chinensis and Lygodium japonicum in the prescription are diuretic and stranguria-relieving. The two are used together as the key medicine for all kinds of stranguria-pain. Talc, Dianthus superbus, and Polygonum multiflorum can clear bladder heat accumulation, clear the water channel, and diuretic and stranguria-relieving. Plantago can clear heat and detoxify, and diuretic and stranguria-relieving. Stir-fried Gardenia can clear triple-burner fire evil, clear the heart and relieve restlessness. Herba Agrimoniae can astringe and stop bleeding, and can be used regardless of cold or heat syndrome. Tangerine peel can invigorate the spleen and harmonize the middle. Licorice can harmonize the medicinal properties. These ten medicines can clear heat and detoxify, diuretic and stranguria-relieving, and at the same time invigorate the spleen and harmonize the middle, and are very effective for heat stranguria-pain.

[0062] The above-mentioned embodiments only express the specific implementation of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A Chinese medicine composition for clearing away heat and detoxifying, characterized in that: The invention comprises the following raw materials in weight proportion: 12-16 parts of Herba Lysimachiae, 6-10 parts of Herba Plantaine, 6-10 parts of Dianthus Superbus, 6-10 parts of Herba Agrimoniae, 6-10 parts of Polygonum Multiflorum, 6-10 parts of Talc, 3-8 parts of Lycopodiella, 3-8 parts of Fried Gardenia Jasminoides, 6-10 parts of Tangerine Peel and 6-10 parts of Licorice Tablets.

2. A Chinese medicine composition for clearing away heat and detoxifying according to claim 1, characterized in that: The invention comprises the following raw materials in weight ratio: 15 parts of Herba Lysimachiae, 9 parts of Herba Plantaginis, 9 parts of Herba Dianthus Superbus, 9 parts of Herba Agrimoniae, 9 parts of Herba Polygoni Multiflori, 9 parts of Talc, 6 parts of Herba Lygodii, 6 parts of Fried Gardenia Jasminoides, 9 parts of Tangerine Peel and 6 parts of Licorice Tablets.

3. A Chinese medicine composition for clearing away heat and detoxifying according to claim 1 or 2, characterized in that: The composition is a preparation prepared from raw medicinal powder as active ingredients.

4. A Chinese medicine composition for clearing away heat and detoxifying according to claim 3, characterized in that: The preparation is an oral preparation.

5. A Chinese medicine composition for clearing away heat and detoxifying according to claim 4, characterized in that: The oral preparation is water extraction or granules.

6. A method for preparing a Chinese medicine composition for clearing away heat and detoxifying, characterized in that: The following steps are involved: S1: Weigh the raw materials according to corresponding weight parts; S2: Grind the raw materials into powder and dry them at 80 degrees.

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